Timothy E O'sullivan

Title(s)Associate Professor, MIMG
ORCID ORCID Icon0000-0003-1435-8188 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NYBS12/2008Biomedical Engineering
    UCSD, San Diego, CAPhD9/2012Cancer Immunology
    Memorial Sloan Kettering Cancer Center, New York, NY6/2017Immunology
    Collapse Awards and Honors
    UCLA2022Regeneron New Investigator Award for Excellence in Cytokine and Interferon Research
    UCLA2021UCLA Life Sciences Excellence in Research Award
    UCLA2019UCSD-UCLA Diabetes Research Center Junior Faculty Award
    MSKCC2016AAI 2016 Thermo Fisher Trainee Achievement Award
    MSKCC2015  - 2017American Cancer Society Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Diabetes and cancer currently represent two of the largest healthcare burdens and leading causes of death in the United States. The O’Sullivan lab seeks to understand the immunoregulatory networks involved in cancer and obesity to develop novel therapeutic strategies that harness the power of the immune system.

    Our studies have focused on defining the signals that promote innate immune cell activation and survival in the context of both pathogen and non-pathogen induced inflammation. We study clinically relevant mouse models and patient samples to understand the role of circulating and tissue-resident innate lymphocytes during host protection and memory responses. We employ cutting-edge genomic techniques to profile transcriptional and epigenetic circuits that lead to functional cell states in health and during viral infection. Understanding the molecular mechanisms of how the mammalian innate immune system is regulated during inflammation will lead to new therapies for cancer and infectious diseases.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Transcriptional mechanisms of natural killer cell responses during mouse cytomegalovirus infection
    NIH R01AI145997May 6, 2019 - Apr 30, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The X-linked epigenetic regulator UTX controls NK cell-intrinsic sex differences. Nature Immunology. 2023. Mandy I Cheng, Joey H Li, Luke Riggan, Bryan Chen, Rana Yakhshi Tafti, Scott Chin, Feiyang Ma, Matteo Pellegrini, Haley Hrncir, Arthur P Arnold, Timothy E O'Sullivan, Maureen A Su . View Publication.
    2. Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production. Cell Rep. 2023 02 28; 42(2):112141. Hildreth AD, Padilla ET, Tafti RY, Legala AR, O'Sullivan TE. PMID: 36807146; PMCID: PMC10435668.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Infection induces tissue-resident memory NK cells that safeguard tissue health. Immunity. 2023 03 14; 56(3):531-546.e6. Schuster IS, Sng XYX, Lau CM, Powell DR, Weizman OE, Fleming P, Neate GEG, Voigt V, Sheppard S, Maraskovsky AI, Daly S, Koyama M, Hill GR, Turner SJ, O'Sullivan TE, Sun JC, Andoniou CE, Degli-Esposti MA. PMID: 36773607; PMCID: PMC10360410.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Single-cell RNA sequencing identifies a population of human liver-type ILC1s. Cell Rep. 2023 01 31; 42(1):111937. Krämer B, Nalin AP, Ma F, Eickhoff S, Lutz P, Leonardelli S, Goeser F, Finnemann C, Hack G, Raabe J, ToVinh M, Ahmad S, Hoffmeister C, Kaiser KM, Manekeller S, Branchi V, Bald T, Hölzel M, Hüneburg R, Nischalke HD, Semaan A, Langhans B, Kaczmarek DJ, Benner B, Lordo MR, Kowalski J, Gerhardt A, Timm J, Toma M, Mohr R, Türler A, Charpentier A, van Bremen T, Feldmann G, Sattler A, Kotsch K, Abdallah AT, Strassburg CP, Spengler U, Carson WE, Mundy-Bosse BL, Pellegrini M, O'Sullivan TE, Freud AG, Nattermann J. PMID: 36640314; PMCID: PMC9950534.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Leukemia inhibitory factor protects against graft-versus-host disease while preserving graft-versus-leukemia activity. Blood. 2022 11 10; 140(19):2076-2090. Wang J, Chang CY, Yang X, Zhou F, Liu J, Zhu S, Yu XZ, Liu C, O'Sullivan TE, Xie P, Feng Z, Hu W. PMID: 35981499; PMCID: PMC9837439.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. The transcription factor Fli1 restricts the formation of memory precursor NK cells during viral infection. Nat Immunol. 2022 04; 23(4):556-567. Riggan L, Ma F, Li JH, Fernandez E, Nathanson DA, Pellegrini M, O'Sullivan TE. PMID: 35288713; PMCID: PMC8989647.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Back to the Future: Spatiotemporal Determinants of NK Cell Antitumor Function. Front Immunol. 2021; 12:816658. Li JH, O'Sullivan TE. PMID: 35082797; PMCID: PMC8785903.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity. Nat Immunol. 2021 05; 22(5):639-653. Hildreth AD, Ma F, Wong YY, Sun R, Pellegrini M, O'Sullivan TE. PMID: 33907320; PMCID: PMC8102391.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    9. Arrested development: suppression of NK cell function in the tumor microenvironment. Clin Transl Immunology. 2021; 10(1):e1238. Riggan L, Shah S, O'Sullivan TE. PMID: 33456775; PMCID: PMC7797224.
      View in: PubMed   Mentions: 19  
    10. CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Primary Innate Immune Cells. STAR Protoc. 2020 12 18; 1(3):100113. Hildreth AD, Riggan L, O'Sullivan TE. PMID: 33377009; PMCID: PMC7756923.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. CRISPR-Cas9 Ribonucleoprotein-Mediated Genomic Editing in Mature Primary Innate Immune Cells. Cell Rep. 2020 05 19; 31(7):107651. Riggan L, Hildreth AD, Rolot M, Wong YY, Satyadi W, Sun R, Huerta C, O'Sullivan TE. PMID: 32433960; PMCID: PMC7294876.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    12. Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes. Immunity. 2020 01 14; 52(1):96-108.e9. Nabekura T, Riggan L, Hildreth AD, O'Sullivan TE, Shibuya A. PMID: 31810881; PMCID: PMC8108607.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    13. Dazed and Confused: NK Cells. Front Immunol. 2019; 10:2235. O'Sullivan TE. PMID: 31616419; PMCID: PMC6763593.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    14. True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity. Trends Immunol. 2019 10; 40(10):909-921. Riggan L, Freud AG, O'Sullivan TE. PMID: 31500958; PMCID: PMC6823149.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    15. Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12. Nat Immunol. 2019 08; 20(8):1004-1011. Weizman OE, Song E, Adams NM, Hildreth AD, Riggan L, Krishna C, Aguilar OA, Leslie CS, Carlyle JR, Sun JC, O'Sullivan TE. PMID: 31263280; PMCID: PMC6697419.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    16. Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection. Viruses. 2019 03 19; 11(3). Hildreth AD, O'Sullivan TE. PMID: 30893756; PMCID: PMC6466361.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Determination of the Fate and Function of Innate Lymphoid Cells Following Adoptive Transfer of Innate Lymphoid Cell Precursors. Methods Mol Biol. 2018; 1799:109-119. O'Sullivan TE, Sun JC. PMID: 29956148.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    18. Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Sci Immunol. 2017 12 08; 2(18). Rapp M, Lau CM, Adams NM, Weizman OE, O'Sullivan TE, Geary CD, Sun JC. PMID: 29222089; PMCID: PMC6265048.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    19. ILC1 Confer Early Host Protection at Initial Sites of Viral Infection. Cell. 2017 Nov 02; 171(4):795-808.e12. Weizman OE, Adams NM, Schuster IS, Krishna C, Pritykin Y, Lau C, Degli-Esposti MA, Leslie CS, Sun JC, O'Sullivan TE. PMID: 29056343; PMCID: PMC5687850.
      View in: PubMed   Mentions: 212     Fields:    Translation:AnimalsCells
    20. Innate Lymphoid Cell Immunometabolism. J Mol Biol. 2017 11 24; 429(23):3577-3586. O'Sullivan TE, Sun JC. PMID: 28867535; PMCID: PMC5719889.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. NK Cell Responses Redefine Immunological Memory. J Immunol. 2016 10 15; 197(8):2963-2970. Adams NM, O'Sullivan TE, Geary CD, Karo JM, Amezquita RA, Joshi NS, Kaech SM, Sun JC. PMID: 27824591; PMCID: PMC5108457.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    22. Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance. Cell Rep. 2016 08 30; 16(9):2348-58. Saddawi-Konefka R, Seelige R, Gross ET, Levy E, Searles SC, Washington A, Santosa EK, Liu B, O'Sullivan TE, Harismendy O, Bui JD. PMID: 27545889; PMCID: PMC5007173.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    23. Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity. 2016 08 16; 45(2):428-41. O'Sullivan TE, Rapp M, Fan X, Weizman OE, Bhardwaj P, Adams NM, Walzer T, Dannenberg AJ, Sun JC. PMID: 27496734; PMCID: PMC5004886.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    24. Atg5 Is Essential for the Development and Survival of Innate Lymphocytes. Cell Rep. 2016 05 31; 15(9):1910-9. O'Sullivan TE, Geary CD, Weizman OE, Geiger TL, Rapp M, Dorn GW, Overholtzer M, Sun JC. PMID: 27210760; PMCID: PMC4889506.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    25. Natural Killer Cell Memory. Immunity. 2015 Oct 20; 43(4):634-45. O'Sullivan TE, Sun JC, Lanier LL. PMID: 26488815; PMCID: PMC4621966.
      View in: PubMed   Mentions: 165     Fields:    Translation:HumansAnimalsCells
    26. BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory. Immunity. 2015 Aug 18; 43(2):331-42. O'Sullivan TE, Johnson LR, Kang HH, Sun JC. PMID: 26253785; PMCID: PMC5737626.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    27. Generation of Natural Killer Cell Memory during Viral Infection. J Innate Immun. 2015; 7(6):557-62. O'Sullivan TE, Sun JC. PMID: 25823611; PMCID: PMC4581887.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    28. Nfil3 is crucial for development of innate lymphoid cells and host protection against intestinal pathogens. J Exp Med. 2014 Aug 25; 211(9):1723-31. Geiger TL, Abt MC, Gasteiger G, Firth MA, O'Connor MH, Geary CD, O'Sullivan TE, van den Brink MR, Pamer EG, Hanash AM, Sun JC. PMID: 25113970; PMCID: PMC4144732.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
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