Heather R Christofk

Title(s)Professor, Biological Chemistry
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis
    NIH R01AR070245Mar 12, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    Nutrient regulation of cancer cell growth
    NIH R01CA215185Dec 6, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Regulation of the Warburg Effect in Cancer
    NIH DP2OD008454Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia. Sci Adv. 2021 Dec 17; 7(51):eabj9889. Campos OA, Attar N, Cheng C, Vogelauer M, Mallipeddi NV, Schmollinger S, Matulionis N, Christofk HR, Merchant SS, Kurdistani SK. PMID: 34919435; PMCID: PMC8682991.
      View in: PubMed   Mentions:    Fields:    
    2. Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. Cancer. 2022 02 15; 128(4):675-684. Lu E, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Zavoshi S, Li S, Zhang L, Wilde BR, Christofk HR, Boutros PC, Shuch B. PMID: 34724198; PMCID: PMC9170268.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. More Metabolism! Mol Cell. 2021 09 16; 81(18):3659-3664. Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K. PMID: 34547228.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):55-73. Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H. PMID: 34414571.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Bonglack EN, Messinger JE, Cable JM, Ch'ng J, Parnell KM, Reinoso-Vizcaíno NM, Barry AP, Russell VS, Dave SS, Christofk HR, Luftig MA. PMID: 34161263; PMCID: PMC8237662.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    6. Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response. Sci Adv. 2021 05; 7(21). Ariav Y, Ch'ng JH, Christofk HR, Ron-Harel N, Erez A. PMID: 34138729; PMCID: PMC8133749.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    7. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 04 21; 11(1):8669. Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. PMID: 33883682; PMCID: PMC8060418.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876. Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183; PMCID: PMC7994801.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    9. Challenges in Studying Stem Cell Metabolism. Cell Stem Cell. 2021 03 04; 28(3):409-423. Perez-Ramirez CA, Christofk HR. PMID: 33667361.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    10. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021 05 04; 33(5):1013-1026.e6. Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. PMID: 33609439; PMCID: PMC8102379.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    11. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss. J Med Chem. 2021 02 25; 64(4):2046-2063. Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME. PMID: 33534563; PMCID: PMC8939290.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. O-Mg! Lactate Drives Mg2+ Mobilization. Mol Cell. 2020 12 03; 80(5):762-763. Wilde BR, Christofk HR. PMID: 33275887.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Aug 13; 23(9):101453. Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192; PMCID: PMC7471621.
      View in: PubMed   Mentions: 19  
    14. GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery. Cell Rep. 2020 07 28; 32(4):107973. Albrecht LV, Tejeda-Muñoz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. PMID: 32726636; PMCID: PMC7666578.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    15. Metabolic Regulation of Tissue Stem Cells. Trends Cell Biol. 2020 07; 30(7):566-576. Shapira SN, Christofk HR. PMID: 32359707; PMCID: PMC8059102.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions:    Fields:    
    17. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    18. Viral hijacking of cellular metabolism. BMC Biol. 2019 07 18; 17(1):59. Thaker SK, Ch'ng J, Christofk HR. PMID: 31319842; PMCID: PMC6637495.
      View in: PubMed   Mentions: 126     Fields:    Translation:Cells
    19. Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 03 26; 10(1):1449. Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. PMID: 30914644; PMCID: PMC6435690.
      View in: PubMed   Mentions:    Fields:    
    20. Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell Metab. 2019 05 07; 29(5):1206-1216.e4. Thaker SK, Chapa T, Garcia G, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR. PMID: 30827860; PMCID: PMC6818653.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    21. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 01 09; 10(1):91. Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. PMID: 30626875; PMCID: PMC6327029.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    22. The next decade of metabolism. Nat Metab. 2019 01; 1(1):2-4. Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M. PMID: 32694817.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    23. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018 09 20; 175(1):117-132.e21. Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. PMID: 30197082; PMCID: PMC6151140.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    24. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. J Vis Exp. 2018 06 21; (136). Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA. PMID: 29985359; PMCID: PMC6101961.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    25. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018 05 14; 33(5):905-921.e5. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 29763624; PMCID: PMC6451645.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    26. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
      View in: PubMed   Mentions: 25  
    27. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 12 12; 6. Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. PMID: 29231167; PMCID: PMC5726851.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    28. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle. J Invest Dermatol. 2018 04; 138(4):968-972. Miranda M, Christofk H, Jones DL, Lowry WE. PMID: 29106930; PMCID: PMC8966693.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    29. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep; 19(9):1017-1026. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. PMID: 28812580; PMCID: PMC5657543.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    30. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017 Sep; 19(9):1027-1036. Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J. PMID: 28812582; PMCID: PMC6137334.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansAnimalsCells
    31. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. PMID: 28648777; PMCID: PMC5521991.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    32. Cell cycle: Division enzyme regulates metabolism. Nature. 2017 06 15; 546(7658):357-358. Krall AS, Christofk HR. PMID: 28607481.
      View in: PubMed   Mentions: 7     Fields:    
    33. Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol. 2017 02 15; 13(2):914. Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, Müschen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG. PMID: 28202506; PMCID: PMC5327725.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    34. Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell Rep. 2017 01 17; 18(3):601-610. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 28099841; PMCID: PMC5260616.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    35. Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell Stem Cell. 2016 10 06; 19(4):476-490. Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. PMID: 27618217; PMCID: PMC5055460.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    36. Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med. 2016 05 04; 8(1):54. Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. PMID: 27146673; PMCID: PMC4857420.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    37. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016 Apr 29; 7:11457. Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. PMID: 27126896; PMCID: PMC4855534.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    38. MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell Rep. 2016 Feb 23; 14(7):1590-1601. Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR. PMID: 26876179; PMCID: PMC4816454.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    39. Rethinking glutamine addiction. Nat Cell Biol. 2015 Dec; 17(12):1515-7. Krall AS, Christofk HR. PMID: 26612572.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    40. MYC-induced reprogramming of glutamine catabolism supports optimal virus replication. Nat Commun. 2015 Nov 12; 6:8873. Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR. PMID: 26561297; PMCID: PMC4660206.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    41. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 01; 22(3):508-15. Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. PMID: 26190651; PMCID: PMC4663076.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    42. Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. J Cell Sci. 2015 Jun 15; 128(12):2236-48. Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML. PMID: 25956888; PMCID: PMC4487014.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    43. The metabolic milieu of metastases. Cell. 2015 Jan 29; 160(3):363-4. Sullivan WJ, Christofk HR. PMID: 25635452.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    44. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    45. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. PMID: 24828042; PMCID: PMC4263271.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    46. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700; PMCID: PMC4294542.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    47. Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. J Cancer Res Clin Oncol. 2014 Mar; 140(3):443-52. Garon EB, Christofk HR, Hosmer W, Britten CD, Bahng A, Crabtree MJ, Hong CS, Kamranpour N, Pitts S, Kabbinavar F, Patel C, von Euw E, Black A, Michelakis ED, Dubinett SM, Slamon DJ. PMID: 24442098; PMCID: PMC3939783.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCellsCTClinical Trials
    48. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. J Nucl Med. 2013 Oct; 54(10):1820-4. Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. PMID: 23978446; PMCID: PMC4106462.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    49. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013; 8(5):e64561. Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. PMID: 23741339; PMCID: PMC3669316.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    50. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-1008. Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. PMID: 23707073; PMCID: PMC3679227.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    51. Cancer: A metabolic metamorphosis. Nature. 2013 Apr 04; 496(7443):38-40. Krall AS, Christofk HR. PMID: 23552939.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    52. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 2013 May 01; 73(9):2850-62. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. PMID: 23440422; PMCID: PMC3919498.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    53. Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. Am J Pathol. 2013 Apr; 182(4):1400-11. Smith KB, Tran LM, Tam BM, Shurell EM, Li Y, Braas D, Tap WD, Christofk HR, Dry SM, Eilber FC, Wu H. PMID: 23416162; PMCID: PMC3620414.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    54. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discov. 2012 Dec; 2(12):1109-17. Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. PMID: 23230188; PMCID: PMC3531869.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    55. Histone acetylation regulates intracellular pH. Mol Cell. 2013 Jan 24; 49(2):310-21. McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. PMID: 23201122; PMCID: PMC3893119.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCells
    56. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct; 8(10):839-47. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. PMID: 22922757; PMCID: PMC3711671.
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