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A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia. Sci Adv. 2021 Dec 17; 7(51):eabj9889.
Campos OA, Attar N, Cheng C, Vogelauer M, Mallipeddi NV, Schmollinger S, Matulionis N, Christofk HR, Merchant SS, Kurdistani SK. PMID: 34919435; PMCID: PMC8682991.
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PubMed Mentions: Fields:
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Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. Cancer. 2022 02 15; 128(4):675-684.
Lu E, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Zavoshi S, Li S, Zhang L, Wilde BR, Christofk HR, Boutros PC, Shuch B. PMID: 34724198; PMCID: PMC9170268.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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More Metabolism! Mol Cell. 2021 09 16; 81(18):3659-3664.
Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K. PMID: 34547228.
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PubMed Mentions: Fields:
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Humans
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Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):55-73.
Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H. PMID: 34414571.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
Bonglack EN, Messinger JE, Cable JM, Ch'ng J, Parnell KM, Reinoso-Vizcaíno NM, Barry AP, Russell VS, Dave SS, Christofk HR, Luftig MA. PMID: 34161263; PMCID: PMC8237662.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response. Sci Adv. 2021 05; 7(21).
Ariav Y, Ch'ng JH, Christofk HR, Ron-Harel N, Erez A. PMID: 34138729; PMCID: PMC8133749.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 04 21; 11(1):8669.
Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. PMID: 33883682; PMCID: PMC8060418.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876.
Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183; PMCID: PMC7994801.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Challenges in Studying Stem Cell Metabolism. Cell Stem Cell. 2021 03 04; 28(3):409-423.
Perez-Ramirez CA, Christofk HR. PMID: 33667361.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021 05 04; 33(5):1013-1026.e6.
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. PMID: 33609439; PMCID: PMC8102379.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss. J Med Chem. 2021 02 25; 64(4):2046-2063.
Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME. PMID: 33534563; PMCID: PMC8939290.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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O-Mg! Lactate Drives Mg2+ Mobilization. Mol Cell. 2020 12 03; 80(5):762-763.
Wilde BR, Christofk HR. PMID: 33275887.
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PubMed Mentions: Fields:
Translation:
Cells
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Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Aug 13; 23(9):101453.
Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192; PMCID: PMC7471621.
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PubMed Mentions:
19
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GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery. Cell Rep. 2020 07 28; 32(4):107973.
Albrecht LV, Tejeda-Muñoz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. PMID: 32726636; PMCID: PMC7666578.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Metabolic Regulation of Tissue Stem Cells. Trends Cell Biol. 2020 07; 30(7):566-576.
Shapira SN, Christofk HR. PMID: 32359707; PMCID: PMC8059102.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
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PubMed Mentions: Fields:
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In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384.
Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Viral hijacking of cellular metabolism. BMC Biol. 2019 07 18; 17(1):59.
Thaker SK, Ch'ng J, Christofk HR. PMID: 31319842; PMCID: PMC6637495.
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PubMed Mentions:
126 Fields:
Translation:
Cells
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Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 03 26; 10(1):1449.
Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. PMID: 30914644; PMCID: PMC6435690.
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PubMed Mentions: Fields:
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Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell Metab. 2019 05 07; 29(5):1206-1216.e4.
Thaker SK, Chapa T, Garcia G, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR. PMID: 30827860; PMCID: PMC6818653.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimalsCells
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Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 01 09; 10(1):91.
Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. PMID: 30626875; PMCID: PMC6327029.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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The next decade of metabolism. Nat Metab. 2019 01; 1(1):2-4.
Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M. PMID: 32694817.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018 09 20; 175(1):117-132.e21.
Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. PMID: 30197082; PMCID: PMC6151140.
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PubMed Mentions:
69 Fields:
Translation:
HumansCells
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Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. J Vis Exp. 2018 06 21; (136).
Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA. PMID: 29985359; PMCID: PMC6101961.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018 05 14; 33(5):905-921.e5.
Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 29763624; PMCID: PMC6451645.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4.
Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
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PubMed Mentions:
25
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Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 12 12; 6.
Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. PMID: 29231167; PMCID: PMC5726851.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle. J Invest Dermatol. 2018 04; 138(4):968-972.
Miranda M, Christofk H, Jones DL, Lowry WE. PMID: 29106930; PMCID: PMC8966693.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep; 19(9):1017-1026.
Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. PMID: 28812580; PMCID: PMC5657543.
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PubMed Mentions:
78 Fields:
Translation:
AnimalsCells
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Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017 Sep; 19(9):1027-1036.
Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J. PMID: 28812582; PMCID: PMC6137334.
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PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7.
Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. PMID: 28648777; PMCID: PMC5521991.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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Cell cycle: Division enzyme regulates metabolism. Nature. 2017 06 15; 546(7658):357-358.
Krall AS, Christofk HR. PMID: 28607481.
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7 Fields:
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Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol. 2017 02 15; 13(2):914.
Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, Müschen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG. PMID: 28202506; PMCID: PMC5327725.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell Rep. 2017 01 17; 18(3):601-610.
Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 28099841; PMCID: PMC5260616.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell Stem Cell. 2016 10 06; 19(4):476-490.
Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. PMID: 27618217; PMCID: PMC5055460.
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PubMed Mentions:
105 Fields:
Translation:
HumansAnimalsCells
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Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med. 2016 05 04; 8(1):54.
Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. PMID: 27146673; PMCID: PMC4857420.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016 Apr 29; 7:11457.
Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. PMID: 27126896; PMCID: PMC4855534.
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PubMed Mentions:
176 Fields:
Translation:
HumansCells
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MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell Rep. 2016 Feb 23; 14(7):1590-1601.
Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR. PMID: 26876179; PMCID: PMC4816454.
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PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Rethinking glutamine addiction. Nat Cell Biol. 2015 Dec; 17(12):1515-7.
Krall AS, Christofk HR. PMID: 26612572.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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MYC-induced reprogramming of glutamine catabolism supports optimal virus replication. Nat Commun. 2015 Nov 12; 6:8873.
Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR. PMID: 26561297; PMCID: PMC4660206.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 01; 22(3):508-15.
Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. PMID: 26190651; PMCID: PMC4663076.
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PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. J Cell Sci. 2015 Jun 15; 128(12):2236-48.
Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML. PMID: 25956888; PMCID: PMC4487014.
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PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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The metabolic milieu of metastases. Cell. 2015 Jan 29; 160(3):363-4.
Sullivan WJ, Christofk HR. PMID: 25635452.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81.
Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. PMID: 24828042; PMCID: PMC4263271.
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PubMed Mentions:
209 Fields:
Translation:
HumansAnimalsCells
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Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701.
Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700; PMCID: PMC4294542.
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PubMed Mentions:
99 Fields:
Translation:
HumansCells
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Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. J Cancer Res Clin Oncol. 2014 Mar; 140(3):443-52.
Garon EB, Christofk HR, Hosmer W, Britten CD, Bahng A, Crabtree MJ, Hong CS, Kamranpour N, Pitts S, Kabbinavar F, Patel C, von Euw E, Black A, Michelakis ED, Dubinett SM, Slamon DJ. PMID: 24442098; PMCID: PMC3939783.
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PubMed Mentions:
54 Fields:
Translation:
HumansCellsCTClinical Trials
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Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. J Nucl Med. 2013 Oct; 54(10):1820-4.
Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. PMID: 23978446; PMCID: PMC4106462.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013; 8(5):e64561.
Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. PMID: 23741339; PMCID: PMC3669316.
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PubMed Mentions:
73 Fields:
Translation:
HumansCells
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EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-1008.
Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. PMID: 23707073; PMCID: PMC3679227.
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PubMed Mentions:
74 Fields:
Translation:
HumansAnimalsCells
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Cancer: A metabolic metamorphosis. Nature. 2013 Apr 04; 496(7443):38-40.
Krall AS, Christofk HR. PMID: 23552939.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 2013 May 01; 73(9):2850-62.
Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. PMID: 23440422; PMCID: PMC3919498.
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PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
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Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. Am J Pathol. 2013 Apr; 182(4):1400-11.
Smith KB, Tran LM, Tam BM, Shurell EM, Li Y, Braas D, Tap WD, Christofk HR, Dry SM, Eilber FC, Wu H. PMID: 23416162; PMCID: PMC3620414.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discov. 2012 Dec; 2(12):1109-17.
Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. PMID: 23230188; PMCID: PMC3531869.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Histone acetylation regulates intracellular pH. Mol Cell. 2013 Jan 24; 49(2):310-21.
McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. PMID: 23201122; PMCID: PMC3893119.
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PubMed Mentions:
105 Fields:
Translation:
HumansCells
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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct; 8(10):839-47.
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. PMID: 22922757; PMCID: PMC3711671.
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PubMed Mentions:
321 Fields:
Translation:
HumansAnimals
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Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway. Genes Dev. 2012 Sep 15; 26(18):2027-37.
Nagaraj R, Gururaja-Rao S, Jones KT, Slattery M, Negre N, Braas D, Christofk H, White KP, Mann R, Banerjee U. PMID: 22925885; PMCID: PMC3444729.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012 Jun; 23(4):352-61.
Bensinger SJ, Christofk HR. PMID: 22406683.
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PubMed Mentions:
139 Fields:
Translation:
HumansAnimalsCells
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Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16062-7.
Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. PMID: 21900605; PMCID: PMC3179043.
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240 Fields:
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HumansCells
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Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries. J Proteome Res. 2011 Sep 02; 10(9):4158-64.
Christofk HR, Wu N, Cantley LC, Asara JM. PMID: 21774532; PMCID: PMC3174226.
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8 Fields:
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HumansCells
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Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010 Sep 17; 329(5998):1492-9.
Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. PMID: 20847263; PMCID: PMC3030121.
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299 Fields:
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HumansAnimalsCells
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Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol. 2010 Apr 15; 79(8):1118-24.
Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. PMID: 20005212; PMCID: PMC2823991.
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112 Fields:
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HumansCells
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008 Mar 13; 452(7184):230-3.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. PMID: 18337823.
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1242 Fields:
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HumansAnimalsCells
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Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008 Mar 13; 452(7184):181-6.
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. PMID: 18337815.
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475 Fields:
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HumansAnimalsCells
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A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen. Proteomics. 2008 Mar; 8(5):994-9.
Asara JM, Christofk HR, Freimark LM, Cantley LC. PMID: 18324724.
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87 Fields:
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HumansCells
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In-gel stable isotope labeling for relative quantification using mass spectrometry. Nat Protoc. 2006; 1(1):46-51.
Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC. PMID: 17406210.
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4 Fields:
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Cells
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Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004 Jun; 24(12):5577-86.
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H. PMID: 15169916; PMCID: PMC419860.
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38 Fields:
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AnimalsCells