Heather R Christofk

Title(s)Professor, Biological Chemistry
SchoolMedicine
ORCID ORCID Icon0000-0002-8662-4425 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCLABS12/2001Molecular, Cell, and Developmental Biology
    HarvardPhD07/2007Cell and Developmental Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis
    NIH R01AR070245Mar 12, 2018 - Feb 28, 2023
    Role: Co-Principal Investigator
    Nutrient regulation of cancer cell growth
    NIH R01CA215185Dec 6, 2017 - Nov 30, 2022
    Role: Principal Investigator
    Regulation of the Warburg Effect in Cancer
    NIH DP2OD008454Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. PLoS Pathog. 2024 Oct 24; 20(10):e1012341. SoRelle ED, Haynes LE, Willard KA, Chang B, Ch'ng J, Christofk H, Luftig MA. PMID: 39446925.
      View in: PubMed   Mentions:    Fields:    
    2. Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma. Sci Adv. 2024 Sep 20; 10(38):eadn2806. Galvan C, Flores AA, Cerrilos V, Avila I, Murphy C, Zheng W, Christofk HR, Lowry WE. PMID: 39303037; PMCID: PMC11414736.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma. Cancers (Basel). 2024 Aug 30; 16(17). Klingbeil KD, Wilde BR, Graham DS, Lofftus S, McCaw T, Matulionis N, Dry SM, Crompton JG, Eilber FC, Graeber TG, Shackelford DB, Christofk HR, Kadera BE. PMID: 39272889; PMCID: PMC11394161.
      View in: PubMed   Mentions:
    4. Metabolic heterogeneity in humans. Cell. 2024 Jul 25; 187(15):3821-3823. Christofk H, Metallo C, Liu G, Rabinowitz J, Sparks L, James D. PMID: 39059358.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. bioRxiv. 2024 Jun 14. SoRelle ED, Haynes LE, Willard KA, Chang B, Ch'ng J, Christofk H, Luftig MA. PMID: 38915538; PMCID: PMC11195279.
      View in: PubMed   Mentions:
    6. Lessons Learned from Cancer Metabolism for Physiology and Disease. Cold Spring Harb Perspect Med. 2024 Jun 10. Campbell SL, Christofk HR. PMID: 38858085.
      View in: PubMed   Mentions:    Fields:    
    7. Segregation, immunohistochemical, molecular and functional analyses classify a novel missense variant in fumarate hydratase (FH) as pathogenic. Genes Chromosomes Cancer. 2024 02; 63(2):e23221. Ouchene L, Wilde B, Chan-Pak-Choon F, Camacho Valenzuela J, Brimo F, Witkowski L, Christofk H, Domecq C, Fu L, Weber E, Lemieux Anglin B, Netchiporouk E, Foulkes WD. PMID: 38682608.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. Cell Rep. 2024 01 23; 43(1):113627. Sunshine HL, Cicchetto AC, Kaczor-Urbanowicz KE, Ma F, Pi D, Symons C, Turner M, Shukla V, Christofk HR, Vallim TA, Iruela-Arispe ML. PMID: 38157296; PMCID: PMC10884959.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy. Cell. 2024 01 04; 187(1):204-215.e14. Perez-Ramirez CA, Nakano H, Law RC, Matulionis N, Thompson J, Pfeiffer A, Park JO, Nakano A, Christofk HR. PMID: 38070508; PMCID: PMC10843853.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    10. Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma. bioRxiv. 2023 Oct 19. Galvan C, Flores A, Cerrillos V, Avila I, Murphy C, Zheng W, To TT, Christofk HR, Lowry WE. PMID: 37905122; PMCID: PMC10614763.
      View in: PubMed   Mentions:
    11. MYC is a regulator of androgen receptor inhibition-induced metabolic requirements in prostate cancer. Cell Rep. 2023 10 31; 42(10):113221. Crowell PD, Giafaglione JM, Jones AE, Nunley NM, Hashimoto T, Delcourt AML, Petcherski A, Agrawal R, Bernard MJ, Diaz JA, Heering KY, Huang RR, Low JY, Matulionis N, Navone NM, Ye H, Zoubeidi A, Christofk HR, Rettig MB, Reiter RE, Haffner MC, Boutros PC, Shirihai OS, Divakaruni AS, Goldstein AS. PMID: 37815914.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth. Sci Adv. 2023 09 08; 9(36):eadi2232. Franco CN, Seabrook LJ, Nguyen ST, Yang Y, Campos M, Fan Q, Cicchetto AC, Kong M, Christofk HR, Albrecht LV. PMID: 37682999; PMCID: PMC10491294.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. FH Variant Pathogenicity Promotes Purine Salvage Pathway Dependence in Kidney Cancer. Cancer Discov. 2023 09 06; 13(9):2072-2089. Wilde BR, Chakraborty N, Matulionis N, Hernandez S, Ueno D, Gee ME, Esplin ED, Ouyang K, Nykamp K, Shuch B, Christofk HR. PMID: 37255402; PMCID: PMC10527600.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    14. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res. 2024 02; 65(2):100434. Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ. PMID: 37640283; PMCID: PMC10839691.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. Nutrient regulation of development and cell fate decisions. Development. 2023 10 15; 150(20). Tu WB, Christofk HR, Plath K. PMID: 37260407; PMCID: PMC10281554.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. ZFP36-mediated mRNA decay regulates metabolism. Cell Rep. 2023 05 30; 42(5):112411. Cicchetto AC, Jacobson EC, Sunshine H, Wilde BR, Krall AS, Jarrett KE, Sedgeman L, Turner M, Plath K, Iruela-Arispe ML, de Aguiar Vallim TQ, Christofk HR. PMID: 37086408; PMCID: PMC10332406.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. Fumarate Hydratase Variants and Their Association With Paraganglioma/Pheochromocytoma. Urology. 2023 06; 176:106-114. Zavoshi S, Lu E, Boutros PC, Zhang L, Harari A, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Wilde B, Christofk H, Shuch B. PMID: 36773955.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nat Cancer. 2022 11; 3(11):1386-1403. Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. PMID: 36411320; PMCID: PMC9701142.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    19. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022 10 11; 17(10):2220-2238. Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. PMID: 36179695; PMCID: PMC9561534.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. A pathogenic role for histone H3 copper reductase activity in a yeast model of Friedreich's ataxia. Sci Adv. 2021 Dec 17; 7(51):eabj9889. Campos OA, Attar N, Cheng C, Vogelauer M, Mallipeddi NV, Schmollinger S, Matulionis N, Christofk HR, Merchant SS, Kurdistani SK. PMID: 34919435; PMCID: PMC8682991.
      View in: PubMed   Mentions: 3     Fields:    
    21. Fumarate hydratase variant prevalence and manifestations among individuals receiving germline testing. Cancer. 2022 02 15; 128(4):675-684. Lu E, Hatchell KE, Nielsen SM, Esplin ED, Ouyang K, Nykamp K, Zavoshi S, Li S, Zhang L, Wilde BR, Christofk HR, Boutros PC, Shuch B. PMID: 34724198; PMCID: PMC9170268.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    22. More Metabolism! Mol Cell. 2021 09 16; 81(18):3659-3664. Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K. PMID: 34547228.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):55-73. Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H. PMID: 34414571.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Monocarboxylate transporter antagonism reveals metabolic vulnerabilities of viral-driven lymphomas. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Bonglack EN, Messinger JE, Cable JM, Ch'ng J, Parnell KM, Reinoso-Vizcaíno NM, Barry AP, Russell VS, Dave SS, Christofk HR, Luftig MA. PMID: 34161263; PMCID: PMC8237662.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response. Sci Adv. 2021 05; 7(21). Ariav Y, Ch'ng JH, Christofk HR, Ron-Harel N, Erez A. PMID: 34138729; PMCID: PMC8133749.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    26. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 04 21; 11(1):8669. Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. PMID: 33883682; PMCID: PMC8060418.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    27. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876. Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183; PMCID: PMC7994801.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    28. Challenges in Studying Stem Cell Metabolism. Cell Stem Cell. 2021 03 04; 28(3):409-423. Perez-Ramirez CA, Christofk HR. PMID: 33667361.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    29. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021 05 04; 33(5):1013-1026.e6. Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. PMID: 33609439; PMCID: PMC8102379.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    30. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss. J Med Chem. 2021 02 25; 64(4):2046-2063. Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME. PMID: 33534563; PMCID: PMC8939290.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    31. O-Mg! Lactate Drives Mg2+ Mobilization. Mol Cell. 2020 12 03; 80(5):762-763. Wilde BR, Christofk HR. PMID: 33275887.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    32. Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression during Ketogenic Diet Therapy. iScience. 2020 Sep 25; 23(9):101453. Sperry J, Condro MC, Guo L, Braas D, Vanderveer-Harris N, Kim KKO, Pope WB, Divakaruni AS, Lai A, Christofk H, Castro MG, Lowenstein PR, Le Belle JE, Kornblum HI. PMID: 32861192; PMCID: PMC7471621.
      View in: PubMed   Mentions: 38  
    33. GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery. Cell Rep. 2020 07 28; 32(4):107973. Albrecht LV, Tejeda-Muñoz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. PMID: 32726636; PMCID: PMC7666578.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    34. Metabolic Regulation of Tissue Stem Cells. Trends Cell Biol. 2020 07; 30(7):566-576. Shapira SN, Christofk HR. PMID: 32359707; PMCID: PMC8059102.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    35. Publisher Correction: In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2020 01; 577(7791):E7. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31896820.
      View in: PubMed   Mentions:    Fields:    
    36. In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer. Nature. 2019 11; 575(7782):380-384. Momcilovic M, Jones A, Bailey ST, Waldmann CM, Li R, Lee JT, Abdelhady G, Gomez A, Holloway T, Schmid E, Stout D, Fishbein MC, Stiles L, Dabir DV, Dubinett SM, Christofk H, Shirihai O, Koehler CM, Sadeghi S, Shackelford DB. PMID: 31666695; PMCID: PMC7328016.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    37. Viral hijacking of cellular metabolism. BMC Biol. 2019 07 18; 17(1):59. Thaker SK, Ch'ng J, Christofk HR. PMID: 31319842; PMCID: PMC6637495.
      View in: PubMed   Mentions: 222     Fields:    Translation:Cells
    38. Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 03 26; 10(1):1449. Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. PMID: 30914644; PMCID: PMC6435690.
      View in: PubMed   Mentions:    Fields:    
    39. Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell Metab. 2019 05 07; 29(5):1206-1216.e4. Thaker SK, Chapa T, Garcia G, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR. PMID: 30827860; PMCID: PMC6818653.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    40. Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin. Nat Commun. 2019 01 09; 10(1):91. Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE. PMID: 30626875; PMCID: PMC6327029.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    41. The next decade of metabolism. Nat Metab. 2019 01; 1(1):2-4. Bäckhed F, Bugianesi E, Christofk H, Dikic I, Gupta R, Mair WB, O'Neill LAJ, Ralser M, Sabatini DM, Tschöp M. PMID: 32694817.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    42. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018 09 20; 175(1):117-132.e21. Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. PMID: 30197082; PMCID: PMC6151140.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    43. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. J Vis Exp. 2018 06 21; (136). Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA. PMID: 29985359; PMCID: PMC6101961.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    44. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018 05 14; 33(5):905-921.e5. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 29763624; PMCID: PMC6451645.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    45. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 2018; 6:4. Garrett M, Sperry J, Braas D, Yan W, Le TM, Mottahedeh J, Ludwig K, Eskin A, Qin Y, Levy R, Breunig JJ, Pajonk F, Graeber TG, Radu CG, Christofk H, Prins RM, Lai A, Liau LM, Coppola G, Kornblum HI. PMID: 29692895; PMCID: PMC5905129.
      View in: PubMed   Mentions: 35  
    46. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 12 12; 6. Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. PMID: 29231167; PMCID: PMC5726851.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    47. Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle. J Invest Dermatol. 2018 04; 138(4):968-972. Miranda M, Christofk H, Jones DL, Lowry WE. PMID: 29106930; PMCID: PMC8966693.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    48. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Nat Cell Biol. 2017 Sep; 19(9):1027-1036. Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J. PMID: 28812582; PMCID: PMC6137334.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    49. Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol. 2017 Sep; 19(9):1017-1026. Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE. PMID: 28812580; PMCID: PMC5657543.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    50. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. PMID: 28648777; PMCID: PMC5521991.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    51. Cell cycle: Division enzyme regulates metabolism. Nature. 2017 06 15; 546(7658):357-358. Krall AS, Christofk HR. PMID: 28607481.
      View in: PubMed   Mentions: 8     Fields:    
    52. Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol. 2017 02 15; 13(2):914. Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, Müschen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG. PMID: 28202506; PMCID: PMC5327725.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    53. Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell Rep. 2017 01 17; 18(3):601-610. Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB. PMID: 28099841; PMCID: PMC5260616.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    54. Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell Stem Cell. 2016 10 06; 19(4):476-490. Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR. PMID: 27618217; PMCID: PMC5055460.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    55. Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med. 2016 05 04; 8(1):54. Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. PMID: 27146673; PMCID: PMC4857420.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    56. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016 Apr 29; 7:11457. Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. PMID: 27126896; PMCID: PMC4855534.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansCells
    57. MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell Rep. 2016 Feb 23; 14(7):1590-1601. Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR. PMID: 26876179; PMCID: PMC4816454.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    58. Rethinking glutamine addiction. Nat Cell Biol. 2015 Dec; 17(12):1515-7. Krall AS, Christofk HR. PMID: 26612572.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    59. MYC-induced reprogramming of glutamine catabolism supports optimal virus replication. Nat Commun. 2015 Nov 12; 6:8873. Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR. PMID: 26561297; PMCID: PMC4660206.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    60. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 01; 22(3):508-15. Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J. PMID: 26190651; PMCID: PMC4663076.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    61. Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. J Cell Sci. 2015 Jun 15; 128(12):2236-48. Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML. PMID: 25956888; PMCID: PMC4487014.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    62. The metabolic milieu of metastases. Cell. 2015 Jan 29; 160(3):363-4. Sullivan WJ, Christofk HR. PMID: 25635452.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    63. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    64. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19; 510(7505):397-401. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J. PMID: 24828042; PMCID: PMC4263271.
      View in: PubMed   Mentions: 283     Fields:    Translation:HumansAnimalsCells
    65. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700; PMCID: PMC4294542.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    66. Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. J Cancer Res Clin Oncol. 2014 Mar; 140(3):443-52. Garon EB, Christofk HR, Hosmer W, Britten CD, Bahng A, Crabtree MJ, Hong CS, Kamranpour N, Pitts S, Kabbinavar F, Patel C, von Euw E, Black A, Michelakis ED, Dubinett SM, Slamon DJ. PMID: 24442098; PMCID: PMC3939783.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCellsCTClinical Trials
    67. Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. J Nucl Med. 2013 Oct; 54(10):1820-4. Wang J, Hwang K, Braas D, Dooraghi A, Nathanson D, Campbell DO, Gu Y, Sandberg T, Mischel P, Radu C, Chatziioannou AF, Phelps ME, Christofk H, Heath JR. PMID: 23978446; PMCID: PMC4106462.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    68. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013; 8(5):e64561. Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR. PMID: 23741339; PMCID: PMC3669316.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    69. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell Metab. 2013 Jun 04; 17(6):1000-1008. Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS. PMID: 23707073; PMCID: PMC3679227.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    70. Cancer: A metabolic metamorphosis. Nature. 2013 Apr 04; 496(7443):38-40. Krall AS, Christofk HR. PMID: 23552939.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    71. An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res. 2013 May 01; 73(9):2850-62. Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. PMID: 23440422; PMCID: PMC3919498.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    72. Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. Am J Pathol. 2013 Apr; 182(4):1400-11. Smith KB, Tran LM, Tam BM, Shurell EM, Li Y, Braas D, Tap WD, Christofk HR, Dry SM, Eilber FC, Wu H. PMID: 23416162; PMCID: PMC3620414.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    73. Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer Discov. 2012 Dec; 2(12):1109-17. Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR. PMID: 23230188; PMCID: PMC3531869.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    74. Histone acetylation regulates intracellular pH. Mol Cell. 2013 Jan 24; 49(2):310-21. McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. PMID: 23201122; PMCID: PMC3893119.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    75. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct; 8(10):839-47. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG. PMID: 22922757; PMCID: PMC3711671.
      View in: PubMed   Mentions: 381     Fields:    Translation:HumansAnimals
    76. Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway. Genes Dev. 2012 Sep 15; 26(18):2027-37. Nagaraj R, Gururaja-Rao S, Jones KT, Slattery M, Negre N, Braas D, Christofk H, White KP, Mann R, Banerjee U. PMID: 22925885; PMCID: PMC3444729.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    77. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012 Jun; 23(4):352-61. Bensinger SJ, Christofk HR. PMID: 22406683.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    78. Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16062-7. Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, Poulou M, Popescu R, Della Donna L, Evers P, Dekmezian C, Reue K, Christofk H, Mischel PS, Pajonk F. PMID: 21900605; PMCID: PMC3179043.
      View in: PubMed   Mentions: 291     Fields:    Translation:HumansCells
    79. Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries. J Proteome Res. 2011 Sep 02; 10(9):4158-64. Christofk HR, Wu N, Cantley LC, Asara JM. PMID: 21774532; PMCID: PMC3174226.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    80. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010 Sep 17; 329(5998):1492-9. Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. PMID: 20847263; PMCID: PMC3030121.
      View in: PubMed   Mentions: 323     Fields:    Translation:HumansAnimalsCells
    81. Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol. 2010 Apr 15; 79(8):1118-24. Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. PMID: 20005212; PMCID: PMC2823991.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    82. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008 Mar 13; 452(7184):230-3. Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. PMID: 18337823.
      View in: PubMed   Mentions: 1391     Fields:    Translation:HumansAnimalsCells
    83. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008 Mar 13; 452(7184):181-6. Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. PMID: 18337815.
      View in: PubMed   Mentions: 519     Fields:    Translation:HumansAnimalsCells
    84. A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen. Proteomics. 2008 Mar; 8(5):994-9. Asara JM, Christofk HR, Freimark LM, Cantley LC. PMID: 18324724.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    85. In-gel stable isotope labeling for relative quantification using mass spectrometry. Nat Protoc. 2006; 1(1):46-51. Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC. PMID: 17406210.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    86. Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004 Jun; 24(12):5577-86. Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H. PMID: 15169916; PMCID: PMC419860.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
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