Peter Tontonoz

Title(s)Professor, Pathology and Laboratory Medicine
SchoolMedicine
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    Title(s)Professor, Biological Chemistry


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    Peter Tontonoz is the Frances and Albert Piansky Endowed Chair and Distinguished Professor of Pathology and Laboratory Medicine and of Biological Chemistry. Dr. Tontonoz received his B.A. from Wesleyan University and his M.D. and Ph.D. from Harvard Medical School. Dr. Tontonoz’s laboratory endeavors to understand regulatory pathways that govern cholesterol, fatty acid and phospholipid metabolism. His work has helped to reveal fundamental mechanisms by which animals maintain cellular and whole-body lipid homeostasis. His group has elucidated pathways for the control of lipid uptake, transport and efflux, and has shown how these pathways impact the function of immune cells and metabolic tissues in both physiology and disease. Dr. Tontonoz is a member of the National Academy of Sciences, the National Academy of Medicine, the American Society for Clinical Investigation, and the Association of American Physicians. He has received a number of national awards, including the Stanley J. Korsmeyer Award from the American Society of Clinical Investigation, the Richard Weitzman Award and the Gerald D. Aurbach Award from the Endocrine Society, and the Jeffrey Hoeg Award from the American Heart Association. Dr. Tontonoz serves on many editorial boards, including those of eLife, Genes & Development, Diabetes, and the Journal of Clinical Investigation.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Adv Sci (Weinh). 2024 Mar 28; e2307201. Vladimir de la Rosa J, Tabraue C, Huang Z, Orizaola MC, Martin-Rodríguez P, Steffensen KR, Zapata JM, Boscá L, Tontonoz P, Alemany S, Treuter E, Castrillo A. PMID: 38549193.
      View in: PubMed   Mentions:    Fields:    
    2. T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption. bioRxiv. 2024 Mar 11. Gao Y, Kennelly JP, Xiao X, Whang E, Ferrari A, Bedard AH, Mack JJ, Nguyen AH, Weston T, Uchiyama LF, Lee MS, Young SG, Bensinger SJ, Tontonoz P. PMID: 38559079; PMCID: PMC10979874.
      View in: PubMed   Mentions:
    3. Aster-B-dependent estradiol synthesis protects female mice from diet-induced obesity. J Clin Invest. 2024 Jan 04; 134(4). Xiao X, Kennelly JP, Feng AC, Cheng L, Romartinez-Alonso B, Bedard A, Gao Y, Cui L, Young SG, Schwabe JW, Tontonoz P. PMID: 38175723; PMCID: PMC10866650.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Defining the Cell Surface Cysteinome Using Two-Step Enrichment Proteomics. JACS Au. 2023 Dec 25; 3(12):3506-3523. Yan T, Boatner LM, Cui L, Tontonoz PJ, Backus KM. PMID: 38155636; PMCID: PMC10751780.
      View in: PubMed   Mentions: 1  
    5. Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen. J Clin Invest. 2023 Dec 01; 133(23). Yang Y, Beigneux AP, Song W, Nguyen LP, Jung H, Tu Y, Weston TA, Tran CM, Xie K, Yu RG, Tran AP, Miyashita K, Nakajima K, Murakami M, Chen YQ, Zhen EY, Kim JR, Kim PH, Birrane G, Tontonoz P, Ploug M, Konrad RJ, Fong LG, Young SG. PMID: 37824203; PMCID: PMC10688983.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023 11 10; 382(6671):eadf0966. Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. PMID: 37943936.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. A PPARγ/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice. J Clin Invest. 2023 11 01; 133(21). Zhang Z, Cui Y, Su V, Wang D, Tol MJ, Cheng L, Wu X, Kim J, Rajbhandari P, Zhang S, Li W, Tontonoz P, Villanueva CJ, Sallam T. PMID: 37909330; PMCID: PMC10617768.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing. Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44):e2313825120. Song W, Beigneux AP, Weston TA, Chen K, Yang Y, Nguyen LP, Guagliardo P, Jung H, Tran AP, Tu Y, Tran C, Birrane G, Miyashita K, Nakajima K, Murakami M, Tontonoz P, Jiang H, Ploug M, Fong LG, Young SG. PMID: 37871217; PMCID: PMC10623010.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Defining the Cell Surface Cysteinome using Two-step Enrichment Proteomics. bioRxiv. 2023 Oct 19. Yan T, Boatner LM, Cui L, Tontonoz P, Backus KM. PMID: 37904933; PMCID: PMC10614875.
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    10. Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake. bioRxiv. 2023 Jul 10. Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. PMID: 37503112; PMCID: PMC10369906.
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    11. Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation. bioRxiv. 2023 May 26. Hong SG, Ashby JW, Kennelly JP, Wu M, Chattopadhyay E, Foreman R, Tontonoz P, Turowski P, Gallagher-Jones M, Mack JJ. PMID: 37292837; PMCID: PMC10246006.
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    12. Cholesterol Transport to the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2023 02 01; 15(2). Kennelly JP, Tontonoz P. PMID: 35940908; PMCID: PMC9899650.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Erratum. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes 2022;71:2256-2271. Diabetes. 2023 Feb 01; 72(2):309. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. PMID: 36409587; PMCID: PMC9871192.
      View in: PubMed   Mentions:    Fields:    
    14. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 01; 5(1):165-181. Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. PMID: 36646756; PMCID: PMC9995220.
      View in: PubMed   Mentions: 4     Fields:    
    15. Measuring Mitochondrial Uncoupling in Mouse Primary Brown Adipocytes Differentiated Ex Vivo. Methods Mol Biol. 2023; 2662:53-65. Veliova M, Tol MJ, Tontonoz P, Shirihai OS, Liesa M. PMID: 37076670.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs. Genes Dev. 2022 Nov-Dec 1; 36(21-24):1129-1144. Bideyan L, López Rodríguez M, Priest C, Kennelly JP, Gao Y, Ferrari A, Rajbhandari P, Feng AC, Tevosian SG, Smale ST, Tontonoz P. PMID: 36522129; PMCID: PMC9851399.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization. Nature. 2023 01; 613(7942):160-168. Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P. PMID: 36477540; PMCID: PMC9995219.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    18. Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome. Diabetes. 2022 11 01; 71(11):2256-2271. Yao T, Yan H, Zhu X, Zhang Q, Kong X, Guo S, Feng Y, Wang H, Hua Y, Zhang J, Mittelman SD, Tontonoz P, Zhou Z, Liu T, Kong X. PMID: 35713959; PMCID: PMC9630087.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    19. A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity. Cancer Discov. 2022 10 05; 12(10):2414-2433. Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts CB, Sun D, Nagarajan S, Diaz L, Sandborg H, Bhattacharyya S, Xia Z, Coussens LM, Tontonoz P, Sherman MH. PMID: 35894778; PMCID: PMC9533011.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    20. NanoSIMS imaging of lipid absorption by intestinal enterocytes. J Lipid Res. 2022 11; 63(11):100290. Chen K, Song W, Russell R, Ferrari A, Darwish T, Tontonoz P, Young SG, Jiang H. PMID: 36179912; PMCID: PMC9672438.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    21. Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2204396119. Palladino END, Bernas T, Green CD, Weigel C, Singh SK, Senkal CE, Martello A, Kennelly JP, Bieberich E, Tontonoz P, Ford DA, Milstien S, Eden ER, Spiegel S. PMID: 36122218; PMCID: PMC9522378.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    22. CRISPR/Cas9 based blockade of IL-10 signaling impairs lipid and tissue homeostasis to accelerate atherosclerosis. Front Immunol. 2022; 13:999470. Shi H, Guo J, Yu Q, Hou X, Liu L, Gao M, Wei L, Zhang L, Huang W, Wang Y, Liu G, Tontonoz P, Xian X. PMID: 36110841; PMCID: PMC9469689.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. Brap regulates liver morphology and hepatocyte turnover via modulation of the Hippo pathway. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2201859119. Priest C, Nagari RT, Bideyan L, Lee SD, Nguyen A, Xiao X, Tontonoz P. PMID: 35476518; PMCID: PMC9171358.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    24. Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J Clin Invest. 2022 03 01; 132(5). Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. PMID: 35229724; PMCID: PMC8884915.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    25. Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver. Proc Natl Acad Sci U S A. 2022 02 15; 119(7). Bideyan L, Fan W, Kaczor-Urbanowicz KE, Priest C, Casero D, Tontonoz P. PMID: 35145035; PMCID: PMC8851562.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Sci Rep. 2021 08 12; 11(1):16409. Guo F, Seldin M, Péterfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. PMID: 34385484; PMCID: PMC8361163.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Hepatic transcriptional responses to fasting and feeding. Genes Dev. 2021 05 01; 35(9-10):635-657. Bideyan L, Nagari R, Tontonoz P. PMID: 33888557; PMCID: PMC8091980.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    28. Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. J Clin Invest. 2021 04 15; 131(8). Ferrara PJ, Rong X, Maschek JA, Verkerke AR, Siripoksup P, Song H, Green TD, Krishnan KC, Johnson JM, Turk J, Houmard JA, Lusis AJ, Drummond MJ, McClung JM, Cox JE, Shaikh SR, Tontonoz P, Holland WL, Funai K. PMID: 33591957; PMCID: PMC8262507.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    29. Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P. PMID: 33376205; PMCID: PMC7812747.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane. Mol Cell Biol. 2020 09 14; 40(19). Ferrari A, He C, Kennelly JP, Sandhu J, Xiao X, Chi X, Jiang H, Young SG, Tontonoz P. PMID: 32719109; PMCID: PMC7491948.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    31. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    32. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 07; 21(7):746-755. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064; PMCID: PMC7778040.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    33. LDL Receptor Pathway Regulation by miR-224 and miR-520d. Front Cardiovasc Med. 2020; 7:81. Salerno AG, van Solingen C, Scotti E, Wanschel ACBA, Afonso MS, Oldebeken SR, Spiro W, Tontonoz P, Rayner KJ, Moore KJ. PMID: 32528976; PMCID: PMC7256473.
      View in: PubMed   Mentions: 9  
    34. ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. Biochemistry. 2020 05 19; 59(19):1793-1799. Ichu TA, Reed A, Ogasawara D, Ulanovskaya O, Roberts A, Aguirre CA, Bar-Peled L, Gao J, Germain J, Barbas S, Masuda K, Conti B, Tontonoz P, Cravatt BF. PMID: 32364701; PMCID: PMC7394188.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. Cultured macrophages transfer surplus cholesterol into adjacent cells in the absence of serum or high-density lipoproteins. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10476-10483. He C, Jiang H, Song W, Riezman H, Tontonoz P, Weston TA, Guagliardo P, Kim PH, Jung R, Heizer P, Fong LG, Young SG. PMID: 32354992; PMCID: PMC7229689.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    36. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metab. 2020 05 05; 31(5):969-986.e7. Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I. PMID: 32259482; PMCID: PMC7313619.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    37. Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice. Mol Cell Biol. 2020 03 30; 40(8). Gao J, Littman R, Diamante G, Xiao X, Ahn IS, Yang X, Cole TA, Tontonoz P. PMID: 31964754; PMCID: PMC7108818.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    38. LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target. JCI Insight. 2020 01 16; 5(1). Choudhary M, Ismail EN, Yao PL, Tayyari F, Radu RA, Nusinowitz S, Boulton ME, Apte RS, Ruberti JW, Handa JT, Tontonoz P, Malek G. PMID: 31829999; PMCID: PMC7030875.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    39. Inter-organ cross-talk in metabolic syndrome. Nat Metab. 2019 12; 1(12):1177-1188. Priest C, Tontonoz P. PMID: 32694672.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    40. IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nat Metab. 2019 11; 1(11):1089-1100. Lee SD, Priest C, Bjursell M, Gao J, Arneson DV, Ahn IS, Diamante G, van Veen JE, Massa MG, Calkin AC, Kim J, Andersén H, Rajbhandari P, Porritt M, Carreras A, Ahnmark A, Seeliger F, Maxvall I, Eliasson P, Althage M, Åkerblad P, Lindén D, Cole TA, Lee R, Boyd H, Bohlooly-Y M, Correa SM, Yang X, Tontonoz P, Hong C. PMID: 32072135; PMCID: PMC7028310.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    41. Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. Elife. 2019 10 23; 8. Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng AC, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, Tontonoz P. PMID: 31644425; PMCID: PMC6837845.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    42. Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. Elife. 2019 09 05; 8. Hu X, Weston TA, He C, Jung RS, Heizer PJ, Young BD, Tu Y, Tontonoz P, Wohlschlegel JA, Jiang H, Young SG, Fong LG. PMID: 31486771; PMCID: PMC6750930.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    43. Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. Genes Dev. 2019 07 01; 33(13-14):747-762. Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ. PMID: 31123067; PMCID: PMC6601513.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    44. Noggin depletion in adipocytes promotes obesity in mice. Mol Metab. 2019 07; 25:50-63. Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI. PMID: 31027994; PMCID: PMC6600080.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    45. Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages. Mol Cell Biol. 2019 03 01; 39(5). Ramón-Vázquez A, de la Rosa JV, Tabraue C, Lopez F, Díaz-Chico BN, Bosca L, Tontonoz P, Alemany S, Castrillo A. PMID: 30602495; PMCID: PMC6379585.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    46. Lnc-ing microRNA activity to atheroprotection. Nat Metab. 2019 Jan; 1(1):10-11. Sallam T, Tontonoz P. PMID: 32694808.
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    47. Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis. J Clin Invest. 2019 01 02; 129(1):281-295. Zhang P, Csaki LS, Ronquillo E, Baufeld LJ, Lin JY, Gutierrez A, Dwyer JR, Brindley DN, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 30507612; PMCID: PMC6307960.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    48. Phospholipid Remodeling in Physiology and Disease. Annu Rev Physiol. 2019 02 10; 81:165-188. Wang B, Tontonoz P. PMID: 30379616; PMCID: PMC7008953.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    49. NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes. Biochem Biophys Res Commun. 2018 10 12; 504(4):899-902. He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H. PMID: 30224066; PMCID: PMC6476570.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    50. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Cell. 2018 10 04; 175(2):514-529.e20. Sandhu J, Li S, Fairall L, Pfisterer SG, Gurnett JE, Xiao X, Weston TA, Vashi D, Ferrari A, Orozco JL, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Ferng A, Lee R, Ford DA, Young SG, Ikonen E, Schwabe JWR, Tontonoz P. PMID: 30220461; PMCID: PMC6469685.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    51. Macrophages release plasma membrane-derived particles rich in accessible cholesterol. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8499-E8508. He C, Hu X, Weston TA, Jung RS, Sandhu J, Huang S, Heizer P, Kim J, Ellison R, Xu J, Kilburn M, Bensinger SJ, Riezman H, Tontonoz P, Fong LG, Jiang H, Young SG. PMID: 30127022; PMCID: PMC6130402.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    52. Liver X receptors in lipid signalling and membrane homeostasis. Nat Rev Endocrinol. 2018 08; 14(8):452-463. Wang B, Tontonoz P. PMID: 29904174; PMCID: PMC6433546.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    53. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metab. 2018 May 01; 27(5):1138-1155.e6. Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ. PMID: 29719227; PMCID: PMC5935137.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    54. NanoSIMS Analysis of Intravascular Lipolysis and Lipid Movement across Capillaries and into Cardiomyocytes. Cell Metab. 2018 May 01; 27(5):1055-1066.e3. He C, Weston TA, Jung RS, Heizer P, Larsson M, Hu X, Allan CM, Tontonoz P, Reue K, Beigneux AP, Ploug M, Holme A, Kilburn M, Guagliardo P, Ford DA, Fong LG, Young SG, Jiang H. PMID: 29719224; PMCID: PMC5945212.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    55. Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis. Mol Cell Biol. 2018 05 15; 38(10). Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. PMID: 29507185; PMCID: PMC5954201.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    56. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 03; 24(3):304-312. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. PMID: 29431742; PMCID: PMC5839972.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    57. Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis. Cell Stem Cell. 2018 02 01; 22(2):206-220.e4. Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martín MG, Alrefai WA, Ford DA, Tontonoz P. PMID: 29395055; PMCID: PMC5807072.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    58. Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress. J Biol Chem. 2018 03 30; 293(13):4735-4751. Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL. PMID: 29378845; PMCID: PMC5880140.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    59. Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function. Circ Res. 2018 01 05; 122(1):155-166. Sallam T, Sandhu J, Tontonoz P. PMID: 29301847; PMCID: PMC5902384.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimals
    60. A Novel Type 2 Diabetes Mouse Model of Combined Diabetic Kidney Disease and Atherosclerosis. Am J Pathol. 2018 02; 188(2):343-352. Bornfeldt KE, Kramer F, Batorsky A, Choi J, Hudkins KL, Tontonoz P, Alpers CE, Kanter JE. PMID: 29154962; PMCID: PMC5785558.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    61. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. PMID: 29249357; PMCID: PMC5766418.
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    62. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 2017 10 25; 6. Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. PMID: 29068315; PMCID: PMC5656429.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    63. The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. Elife. 2017 09 11; 6. Gao J, Marosi M, Choi J, Achiro JM, Kim S, Li S, Otis K, Martin KC, Portera-Cailliau C, Tontonoz P. PMID: 28891791; PMCID: PMC5593505.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    64. ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 02; 127(10):3640-3651. Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P. PMID: 28846071; PMCID: PMC5617651.
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    65. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. J Cell Biol. 2017 10 02; 216(10):3369-3385. Yao J, Guihard PJ, Wu X, Blazquez-Medela AM, Spencer MJ, Jumabay M, Tontonoz P, Fogelman AM, Boström KI, Yao Y. PMID: 28838957; PMCID: PMC5626536.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    66. Long Noncoding RNA Facilitated Gene Therapy Reduces Atherosclerosis in a Murine Model of Familial Hypercholesterolemia. Circulation. 2017 08 22; 136(8):776-778. Tontonoz P, Wu X, Jones M, Zhang Z, Salisbury D, Sallam T. PMID: 28827223; PMCID: PMC5657526.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    67. Phenamil, an amiloride derivative, restricts long bone growth and alters keeled-sternum bone architecture in growing chickens. Poult Sci. 2017 Jul 01; 96(7):2471-2479. Price TR, Moncada K, Leyva-Jimenez H, Park KW, Tontonoz P, Walzem RL. PMID: 28340021; PMCID: PMC5850594.
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    68. Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum. J Lipid Res. 2017 08; 58(8):1636-1647. Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM. PMID: 28592401; PMCID: PMC5538285.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    69. Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia. N Engl J Med. 2017 04 27; 376(17):1647-1658. Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida T, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, Young SG. PMID: 28402248; PMCID: PMC5555413.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    70. Pioneering EBF2 remodels the brown fat chromatin landscape. Genes Dev. 2017 04 01; 31(7):632-633. Wang J, Tontonoz P. PMID: 28446594; PMCID: PMC5411703.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    71. RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs. J Clin Invest. 2017 Mar 01; 127(3):987-1004. Wang J, Rajbhandari P, Damianov A, Han A, Sallam T, Waki H, Villanueva CJ, Lee SD, Nielsen R, Mandrup S, Reue K, Young SG, Whitelegge J, Saez E, Black DL, Tontonoz P. PMID: 28192372; PMCID: PMC5330726.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    72. High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2000-2005. He C, Hu X, Jung RS, Weston TA, Sandoval NP, Tontonoz P, Kilburn MR, Fong LG, Young SG, Jiang H. PMID: 28167768; PMCID: PMC5338444.
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    73. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. PMID: 28002731; PMCID: PMC5181791.
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    74. Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2. Cell Rep. 2016 11 01; 17(6):1671-1682. Kim DH, Kim J, Kwon JS, Sandhu J, Tontonoz P, Lee SK, Lee S, Lee JW. PMID: 27806304.
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    75. An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers. Cancer Cell. 2016 Nov 14; 30(5):683-693. Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. PMID: 27746144; PMCID: PMC5479636.
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    76. Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation. PLoS One. 2016; 11(9):e0162228. Song NJ, Kim S, Jang BH, Chang SH, Yun UJ, Park KM, Waki H, Li DY, Tontonoz P, Park KW. PMID: 27611793; PMCID: PMC5017651.
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    77. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016 06 02; 534(7605):124-8. Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, Katz M, Lee R, Whitelegge J, Tontonoz P. PMID: 27251289; PMCID: PMC4896091.
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    78. Prdm4 induction by the small molecule butein promotes white adipose tissue browning. Nat Chem Biol. 2016 07; 12(7):479-81. Song NJ, Choi S, Rajbhandari P, Chang SH, Kim S, Vergnes L, Kwon SM, Yoon JH, Lee S, Ku JM, Lee JS, Reue K, Koo SH, Tontonoz P, Park KW. PMID: 27159578; PMCID: PMC4912433.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    79. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
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    80. Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metab. 2016 Mar 08; 23(3):492-504. Wang B, Rong X, Duerr MA, Hermanson DJ, Hedde PN, Wong JS, Vallim TQ, Cravatt BF, Gratton E, Ford DA, Tontonoz P. PMID: 26833026; PMCID: PMC4785086.
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    81. The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis. Sci Transl Med. 2015 Nov 18; 7(314):314ra184. Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P. PMID: 26582899; PMCID: PMC7153735.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    82. Palmoplantar Keratoderma in Slurp2-Deficient Mice. J Invest Dermatol. 2016 Feb; 136(2):436-443. Allan CM, Procaccia S, Tran D, Tu Y, Barnes RH, Larsson M, Allan BB, Young LC, Hong C, Tontonoz P, Fong LG, Young SG, Beigneux AP. PMID: 26967477; PMCID: PMC4789766.
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    83. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. J Exp Med. 2015 Nov 16; 212(12):2147-63. Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML. PMID: 26552708; PMCID: PMC4647265.
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    84. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metab. 2016 Jan 12; 23(1):165-78. Tian XY, Ganeshan K, Hong C, Nguyen KD, Qiu Y, Kim J, Tangirala RK, Tontonoz P, Tonotonoz P, Chawla A. PMID: 26549485; PMCID: PMC4715491.
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    85. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015 Jul 14; 4:e08009. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. PMID: 26173179; PMCID: PMC4517437.
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    86. Liver X receptors at the intersection of lipid metabolism and atherogenesis. Atherosclerosis. 2015 Sep; 242(1):29-36. Lee SD, Tontonoz P. PMID: 26164157; PMCID: PMC4546914.
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    87. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015 Mar 25; 4. Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P. PMID: 25806685; PMCID: PMC4400582.
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    88. Genetic architecture of insulin resistance in the mouse. Cell Metab. 2015 Feb 03; 21(2):334-347. Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang WP, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, Lusis AJ. PMID: 25651185; PMCID: PMC4349439.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    89. The orphan nuclear receptor Nur77 is a determinant of myofiber size and muscle mass in mice. Mol Cell Biol. 2015 Apr; 35(7):1125-38. Tontonoz P, Cortez-Toledo O, Wroblewski K, Hong C, Lim L, Carranza R, Conneely O, Metzger D, Chao LC. PMID: 25605333; PMCID: PMC4355536.
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    90. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Rep. 2015 Jan 20; 10(3):326-338. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. PMID: 25600868; PMCID: PMC4501903.
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    91. Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909; PMCID: PMC4342471.
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    92. Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon. Nat Commun. 2014 Nov 24; 5:5494. Ma F, Liu SY, Razani B, Arora N, Li B, Kagechika H, Tontonoz P, Núñez V, Ricote M, Cheng G. PMID: 25417649; PMCID: PMC4380327.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    93. The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice. Cell Metab. 2014 Nov 04; 20(5):910-918. Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P. PMID: 25440061; PMCID: PMC4261644.
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    94. SUMOylation places LRH-1 in PROXimity to lipid metabolism. Cell Metab. 2014 Oct 07; 20(4):558-9. Priest C, Tontonoz P. PMID: 25295783.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    95. Enhanced thermogenesis in the blinc of an eye. Mol Cell. 2014 Aug 07; 55(3):343-4. Jones M, Tontonoz P. PMID: 25105484.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    96. 2014 American Society for Clinical Investigation Presidential Address. Leading by example: pastors, mentors, physician-scientists, and the ASCI. J Clin Invest. 2014 Jul; 124(7):2816-21. Tontonoz P. PMID: 24983420; PMCID: PMC4071402.
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    97. Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1880-7. Chung S, Cuffe H, Marshall SM, McDaniel AL, Ha JH, Kavanagh K, Hong C, Tontonoz P, Temel RE, Parks JS. PMID: 24969772; PMCID: PMC4140949.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    98. Transgenic expression of dominant-active IDOL in liver causes diet-induced hypercholesterolemia and atherosclerosis in mice. Circ Res. 2014 Aug 01; 115(4):442-9. Calkin AC, Lee SD, Kim J, Van Stijn CM, Wu XH, Lusis AJ, Hong C, Tangirala RI, Tontonoz P. PMID: 24935961; PMCID: PMC4119488.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    99. Eosinophils in fat: pink is the new brown. Cell. 2014 Jun 05; 157(6):1249-1250. Lee SD, Tontonoz P. PMID: 24906141.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    100. Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun; 13(6):433-44. Hong C, Tontonoz P. PMID: 24833295.
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    101. The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries. Cell Metab. 2014 May 06; 19(5):849-60. Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG. PMID: 24726386; PMCID: PMC4143151.
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    102. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. J Lipid Res. 2014 06; 55(6):1120-30. Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain BT, Jung ME, Chao LC, Jones M, Gilliland T, Wu X, Su GL, Tangirala RK, Tontonoz P, Hong C. PMID: 24671012; PMCID: PMC4031943.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    103. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5242-7. Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. PMID: 24706823; PMCID: PMC3986138.
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    104. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell. 2014 Jan 30; 156(3):549-62. Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML. PMID: 24485460; PMCID: PMC3985399.
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    105. Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun; 134(6):1589-1598. Adeyo O, Allan BB, Barnes RH, Goulbourne CN, Tatar A, Tu Y, Young LC, Weinstein MM, Tontonoz P, Fong LG, Beigneux AP, Young SG. PMID: 24499735; PMCID: PMC4214150.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    106. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014; 5:3147. Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonoz P, Takahashi S. PMID: 24445679.
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    107. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 05; 18(5):685-97. Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. PMID: 24206663; PMCID: PMC3889491.
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    108. Hormonal modulators of glial ABCA1 and apoE levels. J Lipid Res. 2013 Nov; 54(11):3139-50. Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, Dullaghan E, Galea LA, Pfeifer T, Wellington CL. PMID: 23999864; PMCID: PMC3793618.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    109. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 2013 Jul 02; 18(1):106-17. Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P. PMID: 23823481; PMCID: PMC4089509.
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    110. The nuclear receptor LXRα controls the functional specialization of splenic macrophages. Nat Immunol. 2013 Aug; 14(8):831-9. A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, Li S, Corbi AL, Tontonoz P, Hidalgo A, Castrillo A. PMID: 23770640; PMCID: PMC3720686.
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    111. Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling. Prog Lipid Res. 2013 Jul; 52(3):305-16. Csaki LS, Dwyer JR, Fong LG, Tontonoz P, Young SG, Reue K. PMID: 23603613; PMCID: PMC3830937.
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    112. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013 Mar 05; 17(3):423-35. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 23473036; PMCID: PMC3626567.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    113. Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor. J Lipid Res. 2013 May; 54(5):1410-20. Zhang L, Xu M, Scotti E, Chen ZJ, Tontonoz P. PMID: 23419260; PMCID: PMC3653405.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    114. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol Cell Biol. 2013 Apr; 33(8):1503-14. Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P. PMID: 23382078; PMCID: PMC3624246.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    115. Metabolism: Drug discovery goes for a swim. Nat Chem Biol. 2013 Feb; 9(2):68-9. Choi J, Tontonoz P. PMID: 23334543.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    116. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res. 2013 Mar; 54(3):806-815. Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. PMID: 23288947; PMCID: PMC3617954.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    117. Vestigial-like 3 is an inhibitor of adipocyte differentiation. J Lipid Res. 2013 Feb; 54(2):473-81. Halperin DS, Pan C, Lusis AJ, Tontonoz P. PMID: 23152581; PMCID: PMC3541706.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    118. Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization. J Lipid Res. 2012 Dec; 53(12):2610-9. Chao LC, Wroblewski K, Ilkayeva OR, Stevens RD, Bain J, Meyer GA, Schenk S, Martinez L, Vergnes L, Narkar VA, Drew BG, Hong C, Boyadjian R, Hevener AL, Evans RM, Reue K, Spencer MJ, Newgard CB, Tontonoz P. PMID: 23028113; PMCID: PMC3494265.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    119. Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2541-6. Zhang L, Reue K, Fong LG, Young SG, Tontonoz P. PMID: 22936343; PMCID: PMC4280256.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    120. The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet. 2012; 8(5):e1002709. Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, Reue K. PMID: 22589744; PMCID: PMC3349739.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    121. LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. J Lipid Res. 2012 Jun; 53(6):1126-33. Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, Tontonoz P. PMID: 22454476; PMCID: PMC3351819.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    122. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat Rev Mol Cell Biol. 2012 Mar 14; 13(4):213-24. Calkin AC, Tontonoz P. PMID: 22414897; PMCID: PMC3597092.
      View in: PubMed   Mentions: 321     Fields:    Translation:HumansAnimalsCells
    123. SIRT1 regulation-it ain't all NAD. Mol Cell. 2012 Jan 13; 45(1):9-11. Chao LC, Tontonoz P. PMID: 22244328.
      View in: PubMed   Mentions: 8     Fields:    
    124. Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):230-5. Weinstein MM, Goulbourne CN, Davies BS, Tu Y, Barnes RH, Watkins SM, Davis R, Reue K, Tontonoz P, Beigneux AP, Fong LG, Young SG. PMID: 22173228; PMCID: PMC3281771.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    125. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice. J Clin Invest. 2012 Jan; 122(1):337-47. Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ. PMID: 22156197; PMCID: PMC3248291.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    126. FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20107-12. Calkin AC, Goult BT, Zhang L, Fairall L, Hong C, Schwabe JW, Tontonoz P. PMID: 22109552; PMCID: PMC3250164.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    127. An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov. 2011 Oct; 1(5):442-56. Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, Babic I, Tanaka K, Dang J, Iwanami A, Gini B, Dejesus J, Lisiero DD, Huang TT, Prins RM, Wen PY, Robins HI, Prados MD, Deangelis LM, Mellinghoff IK, Mehta MP, James CD, Chakravarti A, Cloughesy TF, Tontonoz P, Mischel PS. PMID: 22059152; PMCID: PMC3207317.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansAnimalsCells
    128. Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors. Cold Spring Harb Symp Quant Biol. 2011; 76:129-37. Tontonoz P. PMID: 21859674.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    129. GPIHBP1, an endothelial cell transporter for lipoprotein lipase. J Lipid Res. 2011 Nov; 52(11):1869-84. Young SG, Davies BS, Voss CV, Gin P, Weinstein MM, Tontonoz P, Reue K, Bensadoun A, Fong LG, Beigneux AP. PMID: 21844202; PMCID: PMC3196223.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    130. The N342S MYLIP polymorphism is associated with high total cholesterol and increased LDL receptor degradation in humans. J Clin Invest. 2011 Aug; 121(8):3062-71. Weissglas-Volkov D, Calkin AC, Tusie-Luna T, Sinsheimer JS, Zelcer N, Riba L, Tino AM, Ordoñez-Sánchez ML, Cruz-Bautista I, Aguilar-Salinas CA, Tontonoz P, Pajukanta P. PMID: 21765216; PMCID: PMC3148733.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    131. The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor. Genes Dev. 2011 Jun 15; 25(12):1262-74. Zhang L, Fairall L, Goult BT, Calkin AC, Hong C, Millard CJ, Tontonoz P, Schwabe JW. PMID: 21685362; PMCID: PMC3127428.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    132. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011 Apr 06; 13(4):413-427. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. PMID: 21459326; PMCID: PMC3089971.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    133. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol Cell Biol. 2011 May; 31(9):1885-93. Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P. PMID: 21343340; PMCID: PMC3133228.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    134. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res. 2011 Mar; 52(3):531-9. Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. PMID: 21187453; PMCID: PMC3035689.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    135. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. PMID: 21134374; PMCID: PMC3049833.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    136. LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression. J Clin Invest. 2010 Dec; 120(12):4415-24. Feig JE, Pineda-Torra I, Sanson M, Bradley MN, Vengrenyuk Y, Bogunovic D, Gautier EL, Rubinstein D, Hong C, Liu J, Wu C, van Rooijen N, Bhardwaj N, Garabedian M, Tontonoz P, Fisher EA. PMID: 21041949; PMCID: PMC2993578.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    137. Licensing PPARγ to work in macrophages. Immunity. 2010 Nov 24; 33(5):647-9. Villanueva CJ, Tontonoz P. PMID: 21094459; PMCID: PMC3005613.
      View in: PubMed   Mentions: 8     Fields:    
    138. LXR deficiency confers increased protection against visceral Leishmania infection in mice. PLoS Negl Trop Dis. 2010 Nov 16; 4(11):e886. Bruhn KW, Marathe C, Maretti-Mira AC, Nguyen H, Haskell J, Tran TA, Vanchinathan V, Gaur U, Wilson ME, Tontonoz P, Craft N. PMID: 21103366; PMCID: PMC2982826.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    139. Genome-wide association studies identify new targets in cardiovascular disease. Sci Transl Med. 2010 Sep 08; 2(48):48ps46. Calkin AC, Tontonoz P. PMID: 20826839.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    140. Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2106-13. Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG, Young SG. PMID: 20814015; PMCID: PMC2959134.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    141. Liver x receptor signaling pathways and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Aug; 30(8):1513-8. Calkin AC, Tontonoz P. PMID: 20631351; PMCID: PMC2919217.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    142. The small molecule phenamil is a modulator of adipocyte differentiation and PPARgamma expression. J Lipid Res. 2010 Sep; 51(9):2775-84. Park KW, Waki H, Choi SP, Park KM, Tontonoz P. PMID: 20519739; PMCID: PMC2918460.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    143. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem. 2010 Jun 25; 285(26):19720-6. Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N. PMID: 20427281; PMCID: PMC2888382.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    144. Peroxisome proliferator-activated receptor gamma dances with different partners in macrophage and adipocytes. Mol Cell Biol. 2010 May; 30(9):2076-7. Scotti E, Tontonoz P. PMID: 20176804; PMCID: PMC2863579.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    145. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009 Dec; 58(12):2788-96. Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. PMID: 19741162; PMCID: PMC2780886.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    146. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009 Aug 21; 31(2):245-58. A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A. PMID: 19646905; PMCID: PMC2791787.
      View in: PubMed   Mentions: 333     Fields:    Translation:AnimalsCells
    147. Negative regulation of Hedgehog signaling by liver X receptors. Mol Endocrinol. 2009 Oct; 23(10):1532-43. Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F. PMID: 19608643; PMCID: PMC2754896.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    148. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009 Jul 03; 325(5936):100-4. Zelcer N, Hong C, Boyadjian R, Tontonoz P. PMID: 19520913; PMCID: PMC2777523.
      View in: PubMed   Mentions: 373     Fields:    Translation:HumansAnimalsCells
    149. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. Cell Metab. 2009 Jun; 9(6):525-36. Dean JT, Tran L, Beaven S, Tontonoz P, Reue K, Dipple KM, Liao JC. PMID: 19490907; PMCID: PMC4277884.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    150. The small molecule phenamil induces osteoblast differentiation and mineralization. Mol Cell Biol. 2009 Jul; 29(14):3905-14. Park KW, Waki H, Kim WK, Davies BS, Young SG, Parhami F, Tontonoz P. PMID: 19433444; PMCID: PMC2704753.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    151. A Nurr1 pathway for neuroprotection. Cell. 2009 Apr 03; 137(1):26-8. Bensinger SJ, Tontonoz P. PMID: 19345183.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    152. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification. FEBS Lett. 2009 Apr 17; 583(8):1344-8. Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. PMID: 19327357; PMCID: PMC2692939.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    153. Before they were fat: adipocyte progenitors. Cell Metab. 2008 Dec; 8(6):454-7. Park KW, Halperin DS, Tontonoz P. PMID: 19041761.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    154. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol. 2008 Nov 15; 181(10):7176-85. Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. PMID: 18981139; PMCID: PMC2683843.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    155. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008 Dec; 22(12):2596-608. Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. PMID: 18945812; PMCID: PMC2610364.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    156. The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol. 2008 Nov; 22(11):2496-504. Davies BS, Waki H, Beigneux AP, Farber E, Weinstein MM, Wilpitz DC, Tai LJ, Evans RM, Fong LG, Tontonoz P, Young SG. PMID: 18787041; PMCID: PMC2582544.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    157. Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors. Curr Opin Genet Dev. 2008 Oct; 18(5):461-7. Hong C, Tontonoz P. PMID: 18782619; PMCID: PMC2641014.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    158. Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow. J Lipid Res. 2009 Feb; 50(2):214-24. Marathe C, Bradley MN, Hong C, Chao L, Wilpitz D, Salazar J, Tontonoz P. PMID: 18772483; PMCID: PMC2636915.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    159. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. J Lipid Res. 2008 Dec; 49(12):2535-44. Hummasti S, Hong C, Bensinger SJ, Tontonoz P. PMID: 18664718; PMCID: PMC2582369.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    160. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008 Jul 24; 454(7203):470-7. Bensinger SJ, Tontonoz P. PMID: 18650918.
      View in: PubMed   Mentions: 351     Fields:    Translation:HumansAnimalsCells
    161. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008 Jul 11; 134(1):97-111. Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. PMID: 18614014; PMCID: PMC2626438.
      View in: PubMed   Mentions: 332     Fields:    Translation:HumansAnimalsCells
    162. Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Mol Endocrinol. 2008 Sep; 22(9):2038-48. Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. PMID: 18562627; PMCID: PMC2631374.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    163. ApoE promotes the proteolytic degradation of Abeta. Neuron. 2008 Jun 12; 58(5):681-93. Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. PMID: 18549781; PMCID: PMC2493297.
      View in: PubMed   Mentions: 415     Fields:    Translation:AnimalsCells
    164. Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Mol Endocrinol. 2008 Jun; 22(6):1394-402. Gallardo-Soler A, Gómez-Nieto C, Campo ML, Marathe C, Tontonoz P, Castrillo A, Corraliza I. PMID: 18323470; PMCID: PMC5419540.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    165. Adopting new orphans into the family of metabolic regulators. Mol Endocrinol. 2008 Aug; 22(8):1743-53. Hummasti S, Tontonoz P. PMID: 18258684; PMCID: PMC2505328.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    166. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem. 2008; 77:289-312. Tontonoz P, Spiegelman BM. PMID: 18518822.
      View in: PubMed   Mentions: 948     Fields:    Translation:HumansAnimalsCells
    167. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007 Aug; 117(8):2337-46. Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. PMID: 17657314; PMCID: PMC1924496.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    168. N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta. J Med Chem. 2007 Aug 23; 50(17):4255-9. Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, Brock A, Bradley M, Castrillo A, Tontonoz P, Saez E. PMID: 17665897.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    169. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10601-6. Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P. PMID: 17563384; PMCID: PMC1890560.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    170. Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Mol Endocrinol. 2007 Sep; 21(9):2152-63. Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF. PMID: 17550977; PMCID: PMC2602962.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    171. STAMPing out Inflammation. Cell. 2007 May 04; 129(3):451-2. Waki H, Tontonoz P. PMID: 17482536.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    172. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab. 2007 May; 5(5):357-70. Waki H, Park KW, Mitro N, Pei L, Damoiseaux R, Wilpitz DC, Reue K, Saez E, Tontonoz P. PMID: 17488638.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    173. Endocrine functions of adipose tissue. Annu Rev Pathol. 2007; 2:31-56. Waki H, Tontonoz P. PMID: 18039092.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimals
    174. Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2. Infect Immun. 2007 Feb; 75(2):753-9. Cao F, Castrillo A, Tontonoz P, Re F, Byrne GI. PMID: 17145941; PMCID: PMC1828523.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    175. A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor. Circ Res. 2006 Dec 08; 99(12):e88-99. Blaschke F, Takata Y, Caglayan E, Collins A, Tontonoz P, Hsueh WA, Tangirala RK. PMID: 17110595.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    176. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. J Exp Med. 2006 Nov 27; 203(12):2589-602. Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. PMID: 17074929; PMCID: PMC2118146.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    177. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. J Biol Chem. 2006 Oct 27; 281(43):32197-206. Marathe C, Bradley MN, Hong C, Lopez F, Ruiz de Galarreta CM, Tontonoz P, Castrillo A. PMID: 16943198.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    178. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat Med. 2006 Sep; 12(9):1048-55. Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P. PMID: 16906154.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    179. Phosphorylation of the liver X receptors. FEBS Lett. 2006 Sep 04; 580(20):4835-41. Chen M, Bradley MN, Beaven SW, Tontonoz P. PMID: 16904112.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    180. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol. 2006 Oct; 26(10):2301-7. Baldán A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA. PMID: 16888235.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    181. The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis. Mol Endocrinol. 2006 Jun; 20(6):1261-75. Hummasti S, Tontonoz P. PMID: 16556736.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    182. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006 Mar; 116(3):607-14. Zelcer N, Tontonoz P. PMID: 16511593; PMCID: PMC1386115.
      View in: PubMed   Mentions: 387     Fields:    Translation:HumansAnimalsCells
    183. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med. 2006; 57:313-29. Beaven SW, Tontonoz P. PMID: 16409152.
      View in: PubMed   Mentions: 104     Fields:    Translation:Humans
    184. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol. 2006 Apr; 20(4):786-94. Pei L, Castrillo A, Tontonoz P. PMID: 16339277.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    185. SUMOylation and PPARgamma: wrestling with inflammatory signaling. Cell Metab. 2005 Nov; 2(5):273-5. Zelcer N, Tontonoz P. PMID: 16271524.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    186. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J Lipid Res. 2005 Dec; 46(12):2570-9. Chen M, Beaven S, Tontonoz P. PMID: 16170053.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    187. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005 Aug 12; 280(32):29256-62. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. PMID: 15964844.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    188. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab. 2005 Mar; 1(3):201-13. Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. PMID: 16054063.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    189. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 2005 Jan 28; 120(2):261-73. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. PMID: 15680331.
      View in: PubMed   Mentions: 256     Fields:    Translation:Animals
    190. Lesion macrophages are a key target for the antiatherogenic effects of LXR agonists. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):10-1. Bradley MN, Tontonoz P. PMID: 15626767.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    191. PPARs in atherosclerosis: the clot thickens. J Clin Invest. 2004 Dec; 114(11):1538-40. Castrillo A, Tontonoz P. PMID: 15578084; PMCID: PMC529290.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    192. Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. J Lipid Res. 2005 Jan; 46(1):123-34. Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, Tontonoz P, Attie AD, Lopaschuk GD, Lusis AJ. PMID: 15520447.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    193. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004 Oct 15; 119(2):299-309. Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P. PMID: 15479645.
      View in: PubMed   Mentions: 229     Fields:    Translation:AnimalsCells
    194. Fat's loss is bone's gain. J Clin Invest. 2004 Mar; 113(6):805-6. Pei L, Tontonoz P. PMID: 15067310; PMCID: PMC362126.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    195. Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. Annu Rev Cell Dev Biol. 2004; 20:455-80. Castrillo A, Tontonoz P. PMID: 15473848.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    196. Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J Lipid Res. 2004 Apr; 45(4):616-25. Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P. PMID: 14703507.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    197. Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. J Biol Chem. 2004 Mar 12; 279(11):9905-11. Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P. PMID: 14699103.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    198. Setting fat on fire. Nat Med. 2003 Nov; 9(11):1348-9. Walczak R, Tontonoz P. PMID: 14595423.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    199. Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell. 2003 Oct; 12(4):805-16. Castrillo A, Joseph SB, Vaidya SA, Haberland M, Fogelman AM, Cheng G, Tontonoz P. PMID: 14580333.
      View in: PubMed   Mentions: 182     Fields:    Translation:AnimalsCells
    200. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5419-24. Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. PMID: 12697904; PMCID: PMC154360.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    201. Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol. 2003 Jun; 17(6):985-93. Tontonoz P, Mangelsdorf DJ. PMID: 12690094.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansAnimalsCells
    202. LXRs: new therapeutic targets in atherosclerosis? Curr Opin Pharmacol. 2003 Apr; 3(2):192-7. Joseph SB, Tontonoz P. PMID: 12681243.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    203. The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol Cell Biol. 2003 Mar; 23(6):2182-91. Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P. PMID: 12612088; PMCID: PMC149472.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    204. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem. 2003 Mar 21; 278(12):10443-9. Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P. PMID: 12531895.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    205. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med. 2003 Feb; 9(2):213-9. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P. PMID: 12524534.
      View in: PubMed   Mentions: 484     Fields:    Translation:AnimalsCells
    206. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11896-901. Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG. PMID: 12193651; PMCID: PMC129365.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    207. Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production. J Biol Chem. 2002 Dec 27; 277(52):50237-44. Xu J, Xiao G, Trujillo C, Chang V, Blanco L, Joseph SB, Bassilian S, Saad MF, Tontonoz P, Lee WN, Kurland IJ. PMID: 12176975.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    208. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7604-9. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. PMID: 12032330; PMCID: PMC124297.
      View in: PubMed   Mentions: 292     Fields:    Translation:AnimalsCells
    209. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. J Biol Chem. 2002 Aug 30; 277(35):31900-8. Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. PMID: 12032151.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    210. Orphan nuclear receptors find a home in the arterial wall. Curr Atheroscler Rep. 2002 May; 4(3):213-21. Laffitte BA, Tontonoz P. PMID: 11931719.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    211. PPARadigms and PPARadoxes: expanding roles for PPARgamma in the control of lipid metabolism. J Lipid Res. 2002 Feb; 43(2):177-86. Walczak R, Tontonoz P. PMID: 11861659.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    212. Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. J Biol Chem. 2002 Mar 29; 277(13):11019-25. Joseph SB, Laffitte BA, Patel PH, Watson MA, Matsukuma KE, Walczak R, Collins JL, Osborne TF, Tontonoz P. PMID: 11790787.
      View in: PubMed   Mentions: 225     Fields:    Translation:HumansAnimalsCells
    213. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25; 277(4):2908-15. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA. PMID: 11706036.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansAnimalsCells
    214. Autoregulation of the human liver X receptor alpha promoter. Mol Cell Biol. 2001 Nov; 21(22):7558-68. Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P. PMID: 11604492; PMCID: PMC99927.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    215. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents. Mol Pharmacol. 2001 Apr; 59(4):765-73. Singh Ahuja H, Liu S, Crombie DL, Boehm M, Leibowitz MD, Heyman RA, Depre C, Nagy L, Tontonoz P, Davies PJ. PMID: 11259621.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    216. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):507-12. Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. PMID: 11149950; PMCID: PMC14617.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansAnimalsCells
    217. PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med. 2001 Jan; 7(1):48-52. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PMID: 11135615.
      View in: PubMed   Mentions: 326     Fields:    Translation:AnimalsCells
    218. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001 Jan; 7(1):161-71. Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. PMID: 11172721.
      View in: PubMed   Mentions: 423     Fields:    Translation:AnimalsCells
    219. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12097-102. Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. PMID: 11035776; PMCID: PMC17300.
      View in: PubMed   Mentions: 324     Fields:    Translation:HumansAnimalsCells
    220. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res. 2000 Sep 15; 87(6):516-21. Lee H, Shi W, Tontonoz P, Wang S, Subbanagounder G, Hedrick CC, Hama S, Borromeo C, Evans RM, Berliner JA, Nagy L. PMID: 10988245.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    221. Regulation of macrophage gene expression by peroxisome-proliferator-activated receptor gamma: implications for cardiovascular disease. Curr Opin Lipidol. 1999 Dec; 10(6):485-90. Tontonoz P, Nagy L. PMID: 10680041.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    222. Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. J Biol Chem. 1999 May 07; 274(19):13604-12. Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG. PMID: 10224131.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    223. Activators of the nuclear receptor PPARgamma enhance colon polyp formation. Nat Med. 1998 Sep; 4(9):1058-61. Saez E, Tontonoz P, Nelson MC, Alvarez JG, Ming UT, Baird SM, Thomazy VA, Evans RM. PMID: 9734400.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimals
    224. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell. 1998 Apr 17; 93(2):229-40. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. PMID: 9568715.
      View in: PubMed   Mentions: 440     Fields:    Translation:HumansAnimalsCells
    225. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998 Apr 17; 93(2):241-52. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PMID: 9568716.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansAnimalsCells
    226. Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell. 1998 Feb; 1(3):465-70. Mueller E, Sarraf P, Tontonoz P, Evans RM, Martin KJ, Zhang M, Fletcher C, Singer S, Spiegelman BM. PMID: 9660931.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansCells
    227. Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem. 1997 Feb 21; 272(8):5283-90. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. PMID: 9030601.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    228. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):237-41. Tontonoz P, Singer S, Forman BM, Sarraf P, Fletcher JA, Fletcher CD, Brun RP, Mueller E, Altiok S, Oppenheim H, Evans RM, Spiegelman BM. PMID: 8990192; PMCID: PMC19300.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansCells
    229. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 1996 Apr 15; 10(8):974-84. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM. PMID: 8608944.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    230. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 1995 Dec 01; 83(5):803-12. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. PMID: 8521497.
      View in: PubMed   Mentions: 675     Fields:    Translation:AnimalsCells
    231. Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9856-60. Hu E, Tontonoz P, Spiegelman BM. PMID: 7568232; PMCID: PMC40901.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    232. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Curr Opin Genet Dev. 1995 Oct; 5(5):571-6. Tontonoz P, Hu E, Spiegelman BM. PMID: 8664544.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    233. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol. 1995 Jan; 15(1):351-7. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. PMID: 7799943; PMCID: PMC231968.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    234. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994 Dec 30; 79(7):1147-56. Tontonoz P, Hu E, Spiegelman BM. PMID: 8001151.
      View in: PubMed   Mentions: 1104     Fields:    Translation:AnimalsCells
    235. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res. 1994 Dec 25; 22(25):5628-34. Tontonoz P, Graves RA, Budavari AI, Erdjument-Bromage H, Lui M, Hu E, Tempst P, Spiegelman BM. PMID: 7838715; PMCID: PMC310126.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    236. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 1994 May 15; 8(10):1224-34. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. PMID: 7926726.
      View in: PubMed   Mentions: 597     Fields:    Translation:AnimalsCells
    237. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol. 1993 Aug; 13(8):4753-9. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. PMID: 8336713; PMCID: PMC360101.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    238. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem. 1993 Apr 05; 268(10):6823-6. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. PMID: 8463205.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimals
    239. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol. 1992 Jul; 12(7):3313. Graves RA, Tontonoz P, Spiegelman BM. PMID: 1620133; PMCID: PMC364545.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    240. Identification of a fat cell enhancer: analysis of requirements for adipose tissue-specific gene expression. J Cell Biochem. 1992 Jul; 49(3):219-24. Graves RA, Tontonoz P, Platt KA, Ross SR, Spiegelman BM. PMID: 1644859.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    241. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol. 1992 Mar; 12(3):1202-8. Graves RA, Tontonoz P, Spiegelman BM. PMID: 1545801; PMCID: PMC369551.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    242. Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor. Genes Dev. 1991 Mar; 5(3):428-37. Graves RA, Tontonoz P, Ross SR, Spiegelman BM. PMID: 2001842.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
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