Mete Civelek

Title(s)Adjunct Instructor, Anesthesiology
SchoolMedicine
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    1. 14-3-3ζ allows for adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation. Mol Metab. 2025 Jul; 97:102159. Rial SA, You Z, Vivoli A, Paré F, Sean D, AlKhoury A, Lavoie G, Civelek M, Martinez-Sanchez A, Roux PP, Durcan TM, Lim GE. PMID: 40306359; PMCID: PMC12136713.
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    2. Sex chromosomes and cardiovascular disease. Eur J Prev Cardiol. 2025 Apr 15. Spiering AE, Groenheide PJ, Mokry M, Onland-Moret NC, Civelek M, Reue K, Diez Benavente E, den Ruijter HM. PMID: 40231569.
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    3. Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques. Nat Cardiovasc Res. 2025 Apr; 4(4):412-432. Sukhavasi K, Mocci G, Ma L, Hodonsky CJ, Diez Benevante E, Muhl L, Liu J, Gustafsson S, Buyandelger B, Koplev S, Lendahl U, Vanlandewijck M, Singha P, Örd T, Beter M, Selvarajan I, Laakkonen JP, Väli M, den Ruijter HM, Civelek M, Hao K, Ruusalepp A, Betsholtz C, Järve H, Kovacic JC, Miller CL, Romanoski C, Kaikkonen MU, Björkegren JLM. PMID: 40211055; PMCID: PMC11994450.
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    4. Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype. bioRxiv. 2025 Apr 02. Perry RN, Lenert G, Benavente ED, Ma A, Barbera N, Mokry M, de Kleijn DPV, de Winther MPJ, Mayr M, Björkegren JLM, den Ruijter HM, Civelek M. PMID: 40236025; PMCID: PMC11996327.
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    5. Dynamic map illuminates Hippo-cMyc module crosstalk driving cardiomyocyte proliferation. Development. 2025 Feb 15; 152(4). Harris BN, Woo LA, Perry RN, Wallace AM, Civelek M, Wolf MJ, Saucerman JJ. PMID: 39866065; PMCID: PMC11883243.
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    6. Combined effects of genetic background and diet on mouse metabolism and gene expression. iScience. 2024 Dec 20; 27(12):111323. Reed JN, Hasan F, Karkar A, Banka D, Hinkle J, Shastri P, Srivastava N, Scherping SC, Newkirk SE, Ferris HA, Kundu BK, Kranz S, Civelek M, Keller SR. PMID: 39640571; PMCID: PMC11617257.
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    7. The methodological and ethical concerns of genetic studies of same-sex sexual behavior. Am J Hum Genet. 2024 Oct 03; 111(10):2107-2116. Ventresca C, Martschenko DO, Wedow R, Civelek M, Tabery J, Carlson J, Parker SCJ, Ramos PS. PMID: 39255798; PMCID: PMC11480801.
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    8. Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions. Atherosclerosis. 2024 10; 397:118554. Lan T, Palm KCA, Hoeben L, Diez Benavente E, Perry RN, Civelek M, de Kleijn DPV, den Ruijter HM, Pasterkamp G, Mokry M. PMID: 39137621.
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    9. Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche. Nat Cardiovasc Res. 2024 05; 3(5):594-611. Rasheed A, Robichaud S, Dennison T, Nguyen MA, Geoffrion M, Reed JN, Wyatt HJ, Marouf Y, Baxi A, Lee R, Kazan H, Civelek M, van Solingen C, Ouimet M, Rayner KJ. PMID: 39195940.
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    10. Systems genetics analysis of human body fat distribution genes identifies adipocyte processes. Life Sci Alliance. 2024 Jul; 7(7). Reed JN, Huang J, Li Y, Ma L, Banka D, Wabitsch M, Wang T, Ding W, Björkegren JL, Civelek M. PMID: 38702075; PMCID: PMC11068934.
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    11. Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis. Circ Res. 2024 May 24; 134(11):1405-1423. Mocci G, Sukhavasi K, Örd T, Bankier S, Singha P, Arasu UT, Agbabiaje OO, Mäkinen P, Ma L, Hodonsky CJ, Aherrahrou R, Muhl L, Liu J, Gustafsson S, Byandelger B, Wang Y, Koplev S, Lendahl U, Owens GK, Leeper NJ, Pasterkamp G, Vanlandewijck M, Michoel T, Ruusalepp A, Hao K, Ylä-Herttuala S, Väli M, Järve H, Mokry M, Civelek M, Miller CJ, Kovacic JC, Kaikkonen MU, Betsholtz C, Björkegren JLM. PMID: 38639096; PMCID: PMC11122742.
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    12. Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans. Arterioscler Thromb Vasc Biol. 2024 06; 44(6):1419-1431. Diez Benavente E, Hartman RJG, Sakkers TR, Wesseling M, Sloots Y, Slenders L, Boltjes A, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, de Winther MPJ, Kuiper J, Civelek M, van der Laan SW, Horvath S, Onland-Moret NC, Mokry M, Pasterkamp G, den Ruijter HM. PMID: 38634280.
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    13. 14-3-3ζ regulates adipogenesis by modulating chromatin accessibility during the early stages of adipocyte differentiation. bioRxiv. 2024 Mar 19. Rial SA, You Z, Vivoli A, Sean D, Al-Khoury A, Lavoie G, Civelek M, Martinez-Sanchez A, Durcan TM, Lim GE. PMID: 38562727; PMCID: PMC10983991.
      View in: PubMed   Mentions:
    14. Secreted Protein Profiling of Human Aortic Smooth Muscle Cells Identifies Vascular Disease Associations. Arterioscler Thromb Vasc Biol. 2024 04; 44(4):898-914. Aherrahrou R, Baig F, Theofilatos K, Lue D, Beele A, Örd T, Kaikkonen MU, Aherrahrou Z, Cheng Q, Ghosh SKB, Karnewar S, Karnewar V, Finn AV, Owens GK, Joner M, Mayr M, Civelek M. PMID: 38328934; PMCID: PMC10978267.
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    15. Secreted protein profiling of human aortic smooth muscle cells identifies vascular disease associations. medRxiv. 2023 Nov 10. Aherrahrou R, Baig F, Theofilatos K, Lue D, Beele A, Örd T, Kaikkonen MU, Aherrahrou Z, Cheng Q, Ghosh S, Karnewar S, Karnewar V, Finn A, Owens GK, Joner M, Mayr M, Civelek M. PMID: 37986932; PMCID: PMC10659471.
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    16. Sex differences in the genetic and molecular mechanisms of coronary artery disease. Atherosclerosis. 2023 11; 384:117279. Sakkers TR, Mokry M, Civelek M, Erdmann J, Pasterkamp G, Diez Benavente E, den Ruijter HM. PMID: 37805337.
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    17. Systems genetics analysis of human body fat distribution genes identifies Wnt signaling and mitochondrial activity in adipocytes. bioRxiv. 2023 Sep 06. Reed JN, Huang J, Li Y, Ma L, Banka D, Wabitsch M, Wang T, Ding W, Björkegren JLM, Civelek M. PMID: 37732278; PMCID: PMC10508754.
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    18. Female Gene Networks Are Expressed in Myofibroblast-Like Smooth Muscle Cells in Vulnerable Atherosclerotic Plaques. Arterioscler Thromb Vasc Biol. 2023 10; 43(10):1836-1850. Diez Benavente E, Karnewar S, Buono M, Mili E, Hartman RJG, Kapteijn D, Slenders L, Daniels M, Aherrahrou R, Reinberger T, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, Depuydt MAC, de Winther MPJ, Kuiper J, Björkegren JLM, Erdmann J, Civelek M, Mokry M, Owens GK, Pasterkamp G, den Ruijter HM. PMID: 37589136; PMCID: PMC10521798.
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    19. SEMA7a primes integrin α5β1 engagement instructing fibroblast mechanotransduction, phenotype and transcriptional programming. Matrix Biol. 2023 08; 121:179-193. Hu P, Miller AE, Yeh CR, Bingham GC, Civelek M, Barker TH. PMID: 37422024.
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    20. Network Preservation Analysis Reveals Dysregulated Metabolic Pathways in Human Vascular Smooth Muscle Cell Phenotypic Switching. Circ Genom Precis Med. 2023 08; 16(4):372-381. Perry RN, Albarracin D, Aherrahrou R, Civelek M. PMID: 37387208; PMCID: PMC10434832.
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    21. Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation. Elife. 2023 Jun 16; 12. Aberra YT, Ma L, Björkegren JLM, Civelek M. PMID: 37326626; PMCID: PMC10275637.
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    22. FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. Circ Res. 2023 04 28; 132(9):1144-1161. Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL. PMID: 37017084; PMCID: PMC10147587.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques. bioRxiv. 2023 Feb 09. Benavente ED, Karnewar S, Buono M, Mili E, Hartman RJG, Kapteijn D, Slenders L, Daniels M, Aherrahrou R, Reinberger T, Mol BM, de Borst GJ, de Kleijn DPV, Prange KHM, Depuydt MAC, de Winther MPJ, Kuiper J, Björkegren JLM, Erdmann J, Civelek M, Mokry M, Owens GK, Pasterkamp G, den Ruijter HM. PMID: 36798294; PMCID: PMC9934638.
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    24. Multi-omic integration reveals cell-type-specific regulatory networks of insulin resistance in distinct ancestry populations. Cell Syst. 2023 01 18; 14(1):41-57.e8. Xu P, Wang M, Sharma NK, Comeau ME, Wabitsch M, Langefeld CD, Civelek M, Zhang B, Das SK. PMID: 36630956; PMCID: PMC9852073.
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    25. Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes. Circ Res. 2023 02 03; 132(3):323-338. Aherrahrou R, Lue D, Perry RN, Aberra YT, Khan MD, Soh JY, Örd T, Singha P, Yang Q, Gilani H, Benavente ED, Wong D, Hinkle J, Ma L, Sheynkman GM, den Ruijter HM, Miller CL, Björkegren JLM, Kaikkonen MU, Civelek M. PMID: 36597873; PMCID: PMC9898186.
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    26. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. Nat Cardiovasc Res. 2022 Dec; 1(12):1140-1155. Mokry M, Boltjes A, Slenders L, Bel-Bordes G, Cui K, Brouwer E, Mekke JM, Depuydt MAC, Timmerman N, Waissi F, Verwer MC, Turner AW, Khan MD, Hodonsky CJ, Benavente ED, Hartman RJG, van den Dungen NAM, Lansu N, Nagyova E, Prange KHM, Kovacic JC, Björkegren JLM, Pavlos E, Andreakos E, Schunkert H, Owens GK, Monaco C, Finn AV, Virmani R, Leeper NJ, de Winther MPJ, Kuiper J, de Borst GJ, Stroes ESG, Civelek M, de Kleijn DPV, den Ruijter HM, Asselbergs FW, van der Laan SW, Miller CL, Pasterkamp G. PMID: 37920851; PMCID: PMC10621615.
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    27. Genetic regulation of circular RNA expression in human aortic smooth muscle cells and vascular traits. HGG Adv. 2023 01 12; 4(1):100164. Aherrahrou R, Lue D, Civelek M. PMID: 36578771; PMCID: PMC9791433.
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    28. Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism. Diabetes. 2022 04 01; 71(4):677-693. Yang Q, Hinkle J, Reed JN, Aherrahrou R, Xu Z, Harris TE, Stephenson EJ, Musunuru K, Keller SR, Civelek M. PMID: 35081256; PMCID: PMC8965685.
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    29. Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis. Eur Heart J Open. 2022 Jan; 2(1):oeab043. Slenders L, Landsmeer LPL, Cui K, Depuydt MAC, Verwer M, Mekke J, Timmerman N, van den Dungen NAM, Kuiper J, de Winther MPJ, Prange KHM, Ma WF, Miller CL, Aherrahrou R, Civelek M, de Borst GJ, de Kleijn DPV, Asselbergs FW, den Ruijter HM, Boltjes A, Pasterkamp G, van der Laan SW, Mokry M. PMID: 35174364; PMCID: PMC8841481.
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    30. Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. Arterioscler Thromb Vasc Biol. 2021 11; 41(11):2708-2725. Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG. PMID: 34551590; PMCID: PMC8551036.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Genes in human obesity loci are causal obesity genes in C. elegans. PLoS Genet. 2021 09; 17(9):e1009736. Ke W, Reed JN, Yang C, Higgason N, Rayyan L, Wählby C, Carpenter AE, Civelek M, O'Rourke EJ. PMID: 34492009; PMCID: PMC8462697.
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    32. Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci. Circ Res. 2021 07 09; 129(2):240-258. Örd T, Õunap K, Stolze LK, Aherrahrou R, Nurminen V, Toropainen A, Selvarajan I, Lönnberg T, Aavik E, Ylä-Herttuala S, Civelek M, Romanoski CE, Kaikkonen MU. PMID: 34024118; PMCID: PMC8260472.
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    33. A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy. Eur Heart J. 2021 05 07; 42(18):1773-1785. Wierer M, Werner J, Wobst J, Kastrati A, Cepele G, Aherrahrou R, Sager HB, Erdmann J, Dichgans M, Flockerzi V, Civelek M, Dietrich A, Mann M, Schunkert H, Kessler T. PMID: 33829256; PMCID: PMC8104955.
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    34. GSEAplot: A Package for Customizing Gene Set Enrichment Analysis in R. J Comput Biol. 2021 06; 28(6):629-631. Innis SE, Reinaltt K, Civelek M, Anderson WD. PMID: 33861629; PMCID: PMC8219183.
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    35. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. Eur Heart J. 2021 03 01; 42(9):919-933. Hartiala JA, Han Y, Jia Q, Hilser JR, Huang P, Gukasyan J, Schwartzman WS, Cai Z, Biswas S, Trégouët DA, Smith NL, INVENT Consortium, CHARGE Consortium Hemostasis Working Group, GENIUS-CHD Consortium, Seldin M, Pan C, Mehrabian M, Lusis AJ, Bazeley P, Sun YV, Liu C, Quyyumi AA, Scholz M, Thiery J, Delgado GE, Kleber ME, März W, Howe LJ, Asselbergs FW, van Vugt M, Vlachojannis GJ, Patel RS, Lyytikäinen LP, Kähönen M, Lehtimäki T, Nieminen TVM, Kuukasjärvi P, Laurikka JO, Chang X, Heng CK, Jiang R, Kraus WE, Hauser ER, Ferguson JF, Reilly MP, Ito K, Koyama S, Kamatani Y, Komuro I, Biobank Japan, Stolze LK, Romanoski CE, Khan MD, Turner AW, Miller CL, Aherrahrou R, Civelek M, Ma L, Björkegren JLM, Kumar SR, Tang WHW, Hazen SL, Allayee H. PMID: 33532862; PMCID: PMC7936531.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    36. Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching. Circulation. 2021 02 16; 143(7):713-726. Hartman RJG, Owsiany K, Ma L, Koplev S, Hao K, Slenders L, Civelek M, Mokry M, Kovacic JC, Pasterkamp G, Owens G, Björkegren JLM, den Ruijter HM. PMID: 33499648; PMCID: PMC7930467.
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    37. Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. Circ Res. 2020 12 04; 127(12):1552-1565. Aherrahrou R, Guo L, Nagraj VP, Aguhob A, Hinkle J, Chen L, Yuhl Soh J, Lue D, Alencar GF, Boltjes A, van der Laan SW, Farber E, Fuller D, Anane-Wae R, Akingbesote N, Manichaikul AW, Ma L, Kaikkonen MU, Björkegren JLM, Önengüt-Gümüscü S, Pasterkamp G, Miller CL, Owens GK, Finn A, Navab M, Fogelman AM, Berliner JA, Civelek M. PMID: 33040646; PMCID: PMC7718324.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    38. Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis. Genome Res. 2020 10; 30(10):1379-1392. Anderson WD, Soh JY, Innis SE, Dimanche A, Ma L, Langefeld CD, Comeau ME, Das SK, Schadt EE, Björkegren JLM, Civelek M. PMID: 32967914; PMCID: PMC7605264.
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    39. The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Cell Mol Gastroenterol Hepatol. 2021; 11(1):199-220. Tuominen I, Fuqua BK, Pan C, Renaud N, Wroblewski K, Civelek M, Clerkin K, Asaryan A, Haroutunian SG, Loureiro J, Borawski J, Roma G, Knehr J, Carbone W, French S, Parks BW, Hui ST, Mehrabian M, Magyar C, Cantor RM, Ukomadu C, Lusis AJ, Beaven SW. PMID: 32866618; PMCID: PMC7674618.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    40. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
      View in: PubMed   Mentions: 53     Fields:    
    41. Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets. Sci Rep. 2020 07 23; 10(1):12367. Hartman RJG, Kapteijn DMC, Haitjema S, Bekker MN, Mokry M, Pasterkamp G, Civelek M, den Ruijter HM. PMID: 32704153; PMCID: PMC7378217.
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    42. A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling. Am J Hum Genet. 2020 08 06; 107(2):211-221. Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V, FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD. PMID: 32649856; PMCID: PMC7413854.
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    43. Assessing exposure effects on gene expression. Genet Epidemiol. 2020 09; 44(6):601-610. Reifeis SA, Hudgens MG, Civelek M, Mohlke KL, Love MI. PMID: 32511796; PMCID: PMC7429346.
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    44. Transcription Factor KLF14 and Metabolic Syndrome. Front Cardiovasc Med. 2020; 7:91. Yang Q, Civelek M. PMID: 32548128; PMCID: PMC7274157.
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    45. Defining data-driven primary transcript annotations with primaryTranscriptAnnotation in R. Bioinformatics. 2020 05 01; 36(9):2926-2928. Anderson WD, Duarte FM, Civelek M, Guertin MJ. PMID: 31917388; PMCID: PMC7203734.
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    46. A plasma proteogenomic signature for fibromuscular dysplasia. Cardiovasc Res. 2020 01 01; 116(1):63-77. Olin JW, Di Narzo AF, d'Escamard V, Kadian-Dodov D, Cheng H, Georges A, King A, Thomas A, Barwari T, Michelis KC, Bouchareb R, Bander E, Anyanwu A, Stelzer P, Filsoufi F, Florman S, Civelek M, Debette S, Jeunemaitre X, Björkegren JLM, Mayr M, Bouatia-Naji N, Hao K, Kovacic JC. PMID: 31424497; PMCID: PMC6918065.
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    47. Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution. Hum Mol Genet. 2019 12 15; 28(24):4161-4172. Wu Y, Broadaway KA, Raulerson CK, Scott LJ, Pan C, Ko A, He A, Tilford C, Fuchsberger C, Locke AE, Stringham HM, Jackson AU, Narisu N, Kuusisto J, Pajukanta P, Collins FS, Boehnke M, Laakso M, Lusis AJ, Civelek M, Mohlke KL. PMID: 31691812; PMCID: PMC7202621.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    48. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. Elife. 2019 10 17; 8. Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM. PMID: 31621579; PMCID: PMC6850774.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    49. Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits. Am J Hum Genet. 2019 10 03; 105(4):773-787. Raulerson CK, Ko A, Kidd JC, Currin KW, Brotman SM, Cannon ME, Wu Y, Spracklen CN, Jackson AU, Stringham HM, Welch RP, Fuchsberger C, Locke AE, Narisu N, Lusis AJ, Civelek M, Furey TS, Kuusisto J, Collins FS, Boehnke M, Scott LJ, Lin DY, Love MI, Laakso M, Pajukanta P, Mohlke KL. PMID: 31564431; PMCID: PMC6817527.
      View in: PubMed   Mentions: 27     Fields:    
    50. The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1. Stroke. 2019 10; 50(10):2651-2660. Prestel M, Prell-Schicker C, Webb T, Malik R, Lindner B, Ziesch N, Rex-Haffner M, Röh S, Viturawong T, Lehm M, Mokry M, den Ruijter H, Haitjema S, Asare Y, Söllner F, Najafabadi MG, Aherrahrou R, Civelek M, Samani NJ, Mann M, Haffner C, Dichgans M. PMID: 31500558.
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    51. MicroRNAs and regulation of cardiometabolic phenotypes: novel insights into the complexity of genome-wide association studies loci. Cardiovasc Res. 2019 09 01; 115(11):1570-1571. Civelek M, Erdmann J. PMID: 31086972.
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    52. Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction. JCI Insight. 2019 08 08; 5. Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. PMID: 31393858; PMCID: PMC6777908.
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    91. Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. Circ Res. 2015 Jul 31; 117(4):e41-e53. Wu C, Huang RT, Kuo CH, Kumar S, Kim CW, Lin YC, Chen YJ, Birukova A, Birukov KG, Dulin NO, Civelek M, Lusis AJ, Loyer X, Tedgui A, Dai G, Jo H, Fang Y. PMID: 26034042; PMCID: PMC4522239.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    92. Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency. J Vasc Surg. 2016 07; 64(1):202-209.e6. Kenagy RD, Civelek M, Kikuchi S, Chen L, Grieff A, Sobel M, Lusis AJ, Clowes AW. PMID: 25935274; PMCID: PMC4627903.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    93. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. Am J Hum Genet. 2015 Apr 02; 96(4):532-42. Germain M, Chasman DI, de Haan H, Tang W, Lindström S, Weng LC, de Andrade M, de Visser MC, Wiggins KL, Suchon P, Saut N, Smadja DM, Le Gal G, van Hylckama Vlieg A, Di Narzo A, Hao K, Nelson CP, Rocanin-Arjo A, Folkersen L, Monajemi R, Rose LM, Brody JA, Slagboom E, Aïssi D, Gagnon F, Deleuze JF, Deloukas P, Tzourio C, Dartigues JF, Berr C, Taylor KD, Civelek M, Eriksson P, Cardiogenics Consortium, Psaty BM, Houwing-Duitermaat J, Goodall AH, Cambien F, Kraft P, Amouyel P, Samani NJ, Basu S, Ridker PM, Rosendaal FR, Kabrhel C, Folsom AR, Heit J, Reitsma PH, Trégouët DA, Smith NL, Morange PE. PMID: 25772935; PMCID: PMC4385184.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    94. Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways. Nat Commun. 2015 Mar 09; 6:6355. Bahn JH, Ahn J, Lin X, Zhang Q, Lee JH, Civelek M, Xiao X. PMID: 25751603; PMCID: PMC4355961.
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    95. SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes. Diabetologia. 2015 Mar; 58(3):543-8. Germain M, Pezzolesi MG, Sandholm N, McKnight AJ, Susztak K, Lajer M, Forsblom C, Marre M, Parving HH, Rossing P, Toppila I, Skupien J, Roussel R, Ko YA, Ledo N, Folkersen L, Civelek M, Maxwell AP, Tregouet DA, Groop PH, Tarnow L, Hadjadj S. PMID: 25476525; PMCID: PMC5438751.
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    96. Regulation of NF-κB signaling by oxidized glycerophospholipid and IL-1β induced miRs-21-3p and -27a-5p in human aortic endothelial cells. J Lipid Res. 2015 Jan; 56(1):38-50. Romay MC, Che N, Becker SN, Pouldar D, Hagopian R, Xiao X, Lusis AJ, Berliner JA, Civelek M. PMID: 25327529; PMCID: PMC4274069.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    97. From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1809-10. Civelek M, Lusis AJ. PMID: 25142882; PMCID: PMC4142522.
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    98. Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 2014 Jul; 10(7):e1004502. Mäkinen VP, Civelek M, Meng Q, Zhang B, Zhu J, Levian C, Huan T, Segrè AV, Ghosh S, Vivar J, Nikpay M, Stewart AF, Nelson CP, Willenborg C, Erdmann J, Blakenberg S, O'Donnell CJ, März W, Laaksonen R, Epstein SE, Kathiresan S, Shah SH, Hazen SL, Reilly MP, Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium, Lusis AJ, Samani NJ, Schunkert H, Quertermous T, McPherson R, Yang X, Assimes TL. PMID: 25033284; PMCID: PMC4102418.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    99. The WWOX gene modulates high-density lipoprotein and lipid metabolism. Circ Cardiovasc Genet. 2014 Aug; 7(4):491-504. Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, Pajukanta P, Aldaz CM, Genest J. PMID: 24871327; PMCID: PMC4315188.
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    100. Systems genetics approaches to understand complex traits. Nat Rev Genet. 2014 Jan; 15(1):34-48. Civelek M, Lusis AJ. PMID: 24296534; PMCID: PMC3934510.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansAnimals
    101. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J Lipid Res. 2013 Jul; 54(7):1894-905. Erbilgin A, Civelek M, Romanoski CE, Pan C, Hagopian R, Berliner JA, Lusis AJ. PMID: 23667179; PMCID: PMC3679391.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    102. The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo. Cardiovasc Res. 2013 Jul 15; 99(2):315-27. Davies PF, Civelek M, Fang Y, Fleming I. PMID: 23619421; PMCID: PMC3695748.
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    103. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes. 2013 Oct; 62(10):3618-26. Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M. PMID: 23557707; PMCID: PMC3781437.
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    104. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Hum Mol Genet. 2013 Aug 01; 22(15):3023-37. Civelek M, Hagopian R, Pan C, Che N, Yang WP, Kayne PS, Saleem NK, Cederberg H, Kuusisto J, Gargalovic PS, Kirchgessner TG, Laakso M, Lusis AJ. PMID: 23562819; PMCID: PMC3699064.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    105. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res. 2013 Jun 07; 112(12):1602-12. de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. PMID: 23519696; PMCID: PMC3995747.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    106. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 2013 Jan 08; 17(1):141-52. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ. PMID: 23312289; PMCID: PMC3545283.
      View in: PubMed   Mentions: 274     Fields:    Translation:HumansAnimals
    107. Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC Med Genomics. 2012 Dec 06; 5:61. Haas BE, Horvath S, Pietiläinen KH, Cantor RM, Nikkola E, Weissglas-Volkov D, Rissanen A, Civelek M, Cruz-Bautista I, Riba L, Kuusisto J, Kaprio J, Tusie-Luna T, Laakso M, Aguilar-Salinas CA, Pajukanta P. PMID: 23217153; PMCID: PMC3543280.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    108. Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 2012 Oct 09; 126(15):1896-906. Kim JB, Deluna A, Mungrue IN, Vu C, Pouldar D, Civelek M, Orozco L, Wu J, Wang X, Charugundla S, Castellani LW, Rusek M, Jakubowski H, Jakobowski H, Lusis AJ. PMID: 22952318; PMCID: PMC3608429.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    109. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. PMID: 22892838; PMCID: PMC3586763.
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    110. Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes. 2012 Jul; 61(7):1895-902. Stancáková A, Civelek M, Saleem NK, Soininen P, Kangas AJ, Cederberg H, Paananen J, Pihlajamäki J, Bonnycastle LL, Morken MA, Boehnke M, Pajukanta P, Lusis AJ, Collins FS, Kuusisto J, Ala-Korpela M, Laakso M. PMID: 22553379; PMCID: PMC3379649.
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    111. Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circ Res. 2011 Aug 19; 109(5):e27-41. Romanoski CE, Che N, Yin F, Mai N, Pouldar D, Civelek M, Pan C, Lee S, Vakili L, Yang WP, Kayne P, Mungrue IN, Araujo JA, Berliner JA, Lusis AJ. PMID: 21737788; PMCID: PMC3163234.
      View in: PubMed   Mentions: 62     Fields:    
    112. Conducting the metabolic syndrome orchestra. Nat Genet. 2011 Jun; 43(6):506-8. Civelek M, Lusis AJ. PMID: 21614088; PMCID: PMC3934506.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    113. Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress. Antioxid Redox Signal. 2011 Sep 01; 15(5):1427-32. Davies PF, Civelek M. PMID: 21126204; PMCID: PMC3144426.
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    114. Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis. Circ Cardiovasc Genet. 2011 Jun; 4(3):243-52. Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Davies PF. PMID: 21493819; PMCID: PMC3116084.
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    115. Discovery approaches to UPR in athero-susceptible endothelium in vivo. Methods Enzymol. 2011; 489:109-26. Civelek M, Manduchi E, Grant GR, Stoeckert CJ, Davies PF. PMID: 21266227; PMCID: PMC3833809.
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    116. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13450-5. Fang Y, Shi C, Manduchi E, Civelek M, Davies PF. PMID: 20624982; PMCID: PMC2922125.
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    117. Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo. Semin Thromb Hemost. 2010 Apr; 36(3):265-75. Davies PF, Civelek M, Fang Y, Guerraty MA, Passerini AG. PMID: 20533180; PMCID: PMC3817717.
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    118. Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo. Am J Physiol Heart Circ Physiol. 2010 Jan; 298(1):H163-70. Civelek M, Grant GR, Irolla CR, Shi C, Riley RJ, Chiesa OA, Stoeckert CJ, Karanian JW, Pritchard WF, Davies PF. PMID: 19897713; PMCID: PMC2806137.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    119. Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis. Circ Res. 2009 Aug 28; 105(5):453-61. Civelek M, Manduchi E, Riley RJ, Stoeckert CJ, Davies PF. PMID: 19661457; PMCID: PMC2746924.
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    120. Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism. J Appl Physiol (1985). 2002 Dec; 93(6):1907-17. Civelek M, Ainslie K, Garanich JS, Tarbell JM. PMID: 12391063.
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    121. Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Ann Biomed Eng. 2002 Mar; 30(3):371-8. Sharma R, Yellowley CE, Civelek M, Ainslie K, Hodgson L, Tarbell JM, Donahue HJ. PMID: 12051621; PMCID: PMC4472337.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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