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Smale, Stephen

Title(s)Professor, Mimg
Phone64777
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    FASEB Summer Research Conference on Molecular Mechanisms of Immune Cell Development and Function
    NIH/NIAID R13AI118112May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    FASEB SRC on Molecular Mechanisms of Immune Cell Development and Function
    NIH/NIAID R13AI106088Jun 1, 2013 - May 31, 2014
    Role: Co-Principal Investigator
    High throughput screens for modulators of inflammatory cytakine gene expression
    NIH/NIAID R21AI076921May 15, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Pioneer factor interactions in embryonic stem cells
    NIH/NCI R21CA137278May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Selective regulation of pro-inflammatory genes in macrophages
    NIH/NIGMS R01GM086372Sep 30, 2008 - Jul 31, 2016
    Role: Principal Investigator
    Pro-inflammatory gene regulation in a native chromatin environment
    NIH/NCI R01CA127279Jun 1, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Cytokines in Health and Disease: 15th Annual Meeting of the International Cytokin
    NIH/NIAID R13AI077292Oct 24, 2007 - Oct 23, 2008
    Role: Principal Investigator
    Selective gene activation by the NF-kappaB family of transcription factors
    NIH/NIAID R01AI073868Feb 1, 2007 - Jan 31, 2012
    Role: Principal Investigator
    Biological functions and mechanisms of action of Ikaros proteins
    NIH/NIDDK R01DK043726Aug 1, 1996 - Sep 14, 2005
    Role: Principal Investigator
    REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    NIH/NIDDK R29DK043726May 1, 1991 - Jul 31, 1996
    Role: Principal Investigator
    Medical Scientist Training Program
    NIH/NIGMS T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng AC, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, Tontonoz P. Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. Elife. 2019 10 23; 8. PMID: 31644425.
      View in: PubMed
    2. Comoglio F, Simonatto M, Polletti S, Liu X, Smale ST, Barozzi I, Natoli G. Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells. Genes Dev. 2019 09 01; 33(17-18):1159-1174. PMID: 31371436.
      View in: PubMed
    3. Fu K, Chronis C, Soufi A, Bonora G, Edwards M, Smale ST, Zaret KS, Plath K, Pellegrini M. Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming. BMC Genomics. 2018 Dec 22; 19(1):956. PMID: 30577748.
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    4. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 03; 24(3):304-312. PMID: 29431742.
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    5. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. PMID: 29249357.
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    6. Purbey PK, Scumpia PO, Kim PJ, Tong AJ, Iwamoto KS, McBride WH, Smale ST. Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation. Immunity. 2017 09 19; 47(3):421-434.e3. PMID: 28930658.
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    7. Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 2017 Aug 24; 170(5):973-985.e10. PMID: 28841420.
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    8. Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST. Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS Pathog. 2017 Jul; 13(7):e1006496. PMID: 28704551.
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    9. Thomas BJ, Smale ST. The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion. Immunity. 2016 11 15; 45(5):949-951. PMID: 27851919.
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    10. Tong AJ, Liu X, Thomas BJ, Lissner MM, Baker MR, Senagolage MD, Allred AL, Barish GD, Smale ST. A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation. Cell. 2016 Mar 24; 165(1):165-179. PMID: 26924576.
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    11. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. PMID: 26808628.
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    12. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I?B?. J Biol Chem. 2015 Sep 11; 290(37):22446. PMID: 26362542.
      View in: PubMed
    13. Arenzana TL, Schjerven H, Smale ST. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 01; 29(17):1801-16. PMID: 26314708.
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    14. Lissner MM, Thomas BJ, Wee K, Tong AJ, Kollmann TR, Smale ST. Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults. PLoS One. 2015; 10(7):e0132061. PMID: 26147648.
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    15. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I?B?. J Biol Chem. 2015 Feb 20; 290(8):4815. PMID: 25713407.
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    16. Smale ST, Natoli G. Transcriptional control of inflammatory responses. Cold Spring Harb Perspect Biol. 2014 Sep 11; 6(11):a016261. PMID: 25213094.
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    17. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. PMID: 25194055.
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    18. Smale ST, Plevy SE, Weinmann AS, Zhou L, Ramirez-Carrozzi VR, Pope SD, Bhatt DM, Tong AJ. Toward an understanding of the gene-specific and global logic of inducible gene transcription. Cold Spring Harb Symp Quant Biol. 2013; 78:61-8. PMID: 24747344.
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    19. Smale ST. Transcriptional regulation in the immune system: a status report. Trends Immunol. 2014 May; 35(5):190-4. PMID: 24703179.
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    20. Garcia AJ, Ruscetti M, Arenzana TL, Tran LM, Bianci-Frias D, Sybert E, Priceman SJ, Wu L, Nelson PS, Smale ST, Wu H. Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression. Mol Cell Biol. 2014 Jun; 34(11):2017-28. PMID: 24662052.
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    21. Smale ST, Tarakhovsky A, Natoli G. Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol. 2014; 32:489-511. PMID: 24555473.
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    22. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. PMID: 24013668.
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    23. Pandya-Jones A, Bhatt DM, Lin CH, Tong AJ, Smale ST, Black DL. Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. RNA. 2013 Jun; 19(6):811-27. PMID: 23616639.
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    24. Ferreirós-Vidal I, Carroll T, Taylor B, Terry A, Liang Z, Bruno L, Dharmalingam G, Khadayate S, Cobb BS, Smale ST, Spivakov M, Srivastava P, Petretto E, Fisher AG, Merkenschlager M. Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood. 2013 Mar 07; 121(10):1769-82. PMID: 23303821.
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    25. Xu J, Smale ST. Designing an enhancer landscape. Cell. 2012 Nov 21; 151(5):929-31. PMID: 23178114.
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    26. Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T. Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. Biochem Biophys Res Commun. 2013 Jan 04; 430(1):95-100. PMID: 23154183.
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    27. Murray PJ, Smale ST. Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol. 2012 Oct; 13(10):916-24. PMID: 22990889.
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    28. Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G, Black DL, Smale ST. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell. 2012 Jul 20; 150(2):279-90. PMID: 22817891.
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    29. Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol. 2012 May 20; 13(7):659-66. PMID: 22610141.
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    30. Smale ST. Dimer-specific regulatory mechanisms within the NF-?B family of transcription factors. Immunol Rev. 2012 Mar; 246(1):193-204. PMID: 22435556.
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    31. Smale ST. Transcriptional regulation in the innate immune system. Curr Opin Immunol. 2012 Feb; 24(1):51-7. PMID: 22230561.
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    32. Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML. Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-?B family DNA binding. Nat Immunol. 2011 Nov 20; 13(1):95-102. PMID: 22101729.
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    33. Smale ST. Hierarchies of NF-?B target-gene regulation. Nat Immunol. 2011 Jul 19; 12(8):689-94. PMID: 21772277.
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    34. Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ. A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem. 2011 Jul 01; 286(26):23582-90. PMID: 21566115.
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    35. Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale ST, Hibi T, Rothman PB, Kashiwada M, Plevy SE. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J Immunol. 2011 Apr 15; 186(8):4649-55. PMID: 21383239.
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    36. Mukhopadhyay S, Plüddemann A, Hoe JC, Williams KJ, Varin A, Makepeace K, Aknin ML, Bowdish DM, Smale ST, Barclay AN, Gordon S. Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. Cell Host Microbe. 2010 Sep 16; 8(3):236-47. PMID: 20833375.
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    37. Smale ST. Pioneer factors in embryonic stem cells and differentiation. Curr Opin Genet Dev. 2010 Oct; 20(5):519-26. PMID: 20638836.
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    38. Smale ST. Seq-ing LPS-induced enhancers. Immunity. 2010 Mar 26; 32(3):296-8. PMID: 20346768.
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    39. Smale ST. Selective transcription in response to an inflammatory stimulus. Cell. 2010 Mar 19; 140(6):833-44. PMID: 20303874.
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    40. Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev. 2009 Dec 15; 23(24):2824-38. PMID: 20008934.
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    41. Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28. PMID: 19596239.
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    42. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. PMID: 18568028.
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    43. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta. J Biol Chem. 2008 May 02; 283(18):12468-77. PMID: 18319258.
      View in: PubMed
    44. Sridharan R, Smale ST. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J Biol Chem. 2007 Oct 12; 282(41):30227-38. PMID: 17681952.
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    45. Xu J, Pope SD, Jazirehi AR, Attema JL, Papathanasiou P, Watts JA, Zaret KS, Weissman IL, Smale ST. Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12377-82. PMID: 17640912.
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    46. Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL. Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12371-6. PMID: 17640913.
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    47. Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007 Mar; 26(3):335-44. PMID: 17363301.
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    48. Zhou L, Nazarian AA, Xu J, Tantin D, Corcoran LM, Smale ST. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. Mol Cell Biol. 2007 Apr; 27(7):2698-712. PMID: 17242186.
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    49. Li CC, Ramirez-Carrozzi VR, Smale ST. Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitation. Nat Immunol. 2006 Jul; 7(7):692-7. PMID: 16785883.
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    50. Smale ST, Dorshkind K. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006 Apr; 7(4):367-9. PMID: 16550201.
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    51. Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST. Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev. 2006 Feb 01; 20(3):282-96. PMID: 16452502.
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    52. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51. PMID: 16166378.
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    53. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. PMID: 16148093.
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    54. Cobb BS, Nesterova TB, Thompson E, Hertweck A, O'Connor E, Godwin J, Wilson CB, Brockdorff N, Fisher AG, Smale ST, Merkenschlager M. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 02; 201(9):1367-73. PMID: 15867090.
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    55. Su RC, Sridharan R, Smale ST. Assembly of silent chromatin during thymocyte development. Semin Immunol. 2005 Apr; 17(2):129-40. PMID: 15737574.
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    56. Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale ST. Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet. 2004 May; 36(5):502-6. PMID: 15098035.
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    57. Zhou L, Nazarian AA, Smale ST. Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Mol Cell Biol. 2004 Mar; 24(6):2385-96. PMID: 14993278.
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    58. Cupit PM, Hansen JD, McCarty AS, White G, Chioda M, Spada F, Smale ST, Cunningham C. Ikaros family members from the agnathan Myxine glutinosa and the urochordate Oikopleura dioica: emergence of an essential transcription factor for adaptive immunity. J Immunol. 2003 Dec 01; 171(11):6006-13. PMID: 14634112.
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    59. Liberg D, Smale ST, Merkenschlager M. Upstream of Ikaros. Trends Immunol. 2003 Nov; 24(11):567-70. PMID: 14596876.
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    60. Bradley MN, Zhou L, Smale ST. C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages. Mol Cell Biol. 2003 Jul; 23(14):4841-58. PMID: 12832471.
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    61. Smale ST. The establishment and maintenance of lymphocyte identity through gene silencing. Nat Immunol. 2003 Jul; 4(7):607-15. PMID: 12830135.
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    62. Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity. 2003 Jul; 19(1):131-44. PMID: 12871645.
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    63. Smale ST. A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle. Immunity. 2003 Jul; 19(1):1-2. PMID: 12871632.
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    64. Ronni T, Agarwal V, Haykinson M, Haberland ME, Cheng G, Smale ST. Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol. 2003 Apr; 23(7):2543-55. PMID: 12640135.
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    65. Smale ST, Kadonaga JT. The RNA polymerase II core promoter. Annu Rev Biochem. 2003; 72:449-79. PMID: 12651739.
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    66. McCarty AS, Kleiger G, Eisenberg D, Smale ST. Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell. 2003 Feb; 11(2):459-70. PMID: 12620233.
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    67. Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST. A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev. 2002 Dec 01; 16(23):2985-90. PMID: 12464629.
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    68. Smale ST, Fisher AG. Chromatin structure and gene regulation in the immune system. Annu Rev Immunol. 2002; 20:427-62. PMID: 11861609.
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