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Stephen Smale

Title(s)Professor, MIMG
SchoolMedicine
Address760 Westwood Plaza 5-748
Los Angeles CA 90024
Phone64777
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, Berkeley, CaliforniaPh.D. 1986Biochemistry
    Cornell University, Ithaca, New YorkA.B.1981Chemistry
    Collapse Awards and Honors
    American Association for the Advancement of Science 2020Fellow
    Keystone Symposium, “Transcription and RNA Regulation in Inflammation and Immunity,” Tahoe City, CA2019Keynote Speaker
    The 28th Annual Molecular Biology Retreat, University of Colorado, Denver, Snow Mountain Ranch, CO2017Keynote Speaker
    UCLA2016Life Sciences Excellence Award in Educational Innovation

    Collapse Overview 
    Collapse Overview
    Stephen T. Smale is a molecular immunologist and biochemist who arrived at UCLA in 1990 as an Assistant Professor in the Department of Microbiology and Immunology within the UCLA School of Medicine. In 1999, he was promoted to Professor and, in 2014, to Distinguished Professor, in the Department of Microbiology, Immunology, and Molecular Genetics, which spans the UCLA College of Letters and Science and the David Geffen School of Medicine. From 1990 to 2007, he was also a Howard Hughes Medical Institute Investigator. Dr. Smale graduated Magna Cum Laude from Cornell University, with Honors and Distinction in Chemistry. He received his Ph.D. in Biochemistry from the University of California, Berkeley under the mentorship of Dr. Robert Tjian. He then was a Helen Hay Whitney Foundation postdoctoral fellow with Nobelist Dr. David Baltimore at the Whitehead Institute, MIT. At UCLA, Dr. Smale previously served as Vice Chair of the Department of Microbiology, Immunology, and Molecular Genetics, Director of Basic and Translational Research for the UCLA Jonsson Comprehensive Cancer Center, Director of the Howard Hughes Medical Institute Science Education Program, Co-Director of the UCLA-Caltech Medical Scientist Training Program, and founding Chair of the School of Medicine's Research Initiative in Immunity, Inflammation, infection, and Transplantation (I3T). He currently serves as Vice Dean for Research in the David Geffen School of Medicine. The research in Dr. Smale's laboratory focuses on gene regulation during inflammatory and innate immune responses and during lymphocyte development and leukemogenesis.

    Collapse Research 
    Collapse Research Activities and Funding
    FASEB Summer Research Conference on Molecular Mechanisms of Immune Cell Development and Function
    NIH/NIAID R13AI118112May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Ribonomics of Gene Regulation to predict Innate Immune Responses
    NIH/NHGRI U01HG007912Jan 5, 2015 - Nov 30, 2017
    Role: Co-Investigator
    FASEB SRC on Molecular Mechanisms of Immune Cell Development and Function
    NIH/NIAID R13AI106088Jun 1, 2013 - May 31, 2014
    Role: Co-Principal Investigator
    Immunobiology of Leprosy
    NIH/NIAMS P50AR063020Aug 16, 2012 - Jul 31, 2017
    Role: Co-Investigator
    High throughput screens for modulators of inflammatory cytakine gene expression
    NIH/NIAID R21AI076921May 15, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Pioneer factor interactions in embryonic stem cells
    NIH/NCI R21CA137278May 1, 2009 - Apr 30, 2011
    Role: Principal Investigator
    Selective regulation of pro-inflammatory genes in macrophages
    NIH/NIGMS R01GM086372Sep 30, 2008 - Jul 31, 2016
    Role: Principal Investigator
    Pro-inflammatory gene regulation in a native chromatin environment
    NIH/NCI R01CA127279Jun 1, 2008 - Apr 30, 2012
    Role: Principal Investigator
    Cytokines in Health and Disease: 15th Annual Meeting of the International Cytokin
    NIH/NIAID R13AI077292Oct 24, 2007 - Oct 23, 2008
    Role: Principal Investigator
    Selective gene activation by the NF-kappaB family of transcription factors
    NIH/NIAID R01AI073868Feb 1, 2007 - Jan 31, 2012
    Role: Principal Investigator
    The UCLA Center for Medical Countermeasures Against Radiation
    NIH/NIAID U19AI067769Aug 31, 2005 - Jul 31, 2020
    Role: Co-Investigator
    Biological functions and mechanisms of action of Ikaros proteins
    NIH/NIDDK R01DK043726Aug 1, 1996 - Sep 14, 2005
    Role: Principal Investigator
    REGULATION OF TDT EXPRESSION DURING LYMPHOPOIESIS
    NIH/NIDDK R29DK043726May 1, 1991 - Jul 31, 1996
    Role: Principal Investigator
    UCLA-Caltech Medical Scientist Training Program
    NIH/NIGMS T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell Metab. 2020 Jul 07; 32(1):128-143.e5. Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. PMID: 32516576.
      View in: PubMed   Mentions:    Fields:    
    2. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 Jul; 21(7):746-755. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064.
      View in: PubMed   Mentions:    Fields:    
    3. A Future Outlook on Molecular Mechanisms of Immunity. Trends Immunol. 2020 Jul; 41(7):549-555. Weinmann AS, Youngblood BA, Smale ST, Brink R, Schatz DG, McHeyzer-Williams M. PMID: 32507312.
      View in: PubMed   Mentions:    Fields:    
    4. Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. Elife. 2019 10 23; 8. Rajbhandari P, Arneson D, Hart SK, Ahn IS, Diamante G, Santos LC, Zaghari N, Feng AC, Thomas BJ, Vergnes L, Lee SD, Rajbhandari AK, Reue K, Smale ST, Yang X, Tontonoz P. PMID: 31644425.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Dissection of acute stimulus-inducible nucleosome remodeling in mammalian cells. Genes Dev. 2019 09 01; 33(17-18):1159-1174. Comoglio F, Simonatto M, Polletti S, Liu X, Smale ST, Barozzi I, Natoli G. PMID: 31371436.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming. BMC Genomics. 2018 Dec 22; 19(1):956. Fu K, Chronis C, Soufi A, Bonora G, Edwards M, Smale ST, Zaret KS, Plath K, Pellegrini M. PMID: 30577748.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 03; 24(3):304-312. Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P. PMID: 29431742.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    8. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. PMID: 29249357.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    9. Defined Sensing Mechanisms and Signaling Pathways Contribute to the Global Inflammatory Gene Expression Output Elicited by Ionizing Radiation. Immunity. 2017 09 19; 47(3):421-434.e3. Purbey PK, Scumpia PO, Kim PJ, Tong AJ, Iwamoto KS, McBride WH, Smale ST. PMID: 28930658.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 2017 Aug 24; 170(5):973-985.e10. Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. PMID: 28841420.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    11. Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS Pathog. 2017 Jul; 13(7):e1006496. Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST. PMID: 28704551.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. The Ly6C(lo)-Down: Targeting Developmental Enhancers for Cell Subset Depletion. Immunity. 2016 11 15; 45(5):949-951. Thomas BJ, Smale ST. PMID: 27851919.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation. Cell. 2016 Mar 24; 165(1):165-179. Tong AJ, Liu X, Thomas BJ, Lissner MM, Baker MR, Senagolage MD, Allred AL, Barish GD, Smale ST. PMID: 26924576.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    14. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. PLoS Pathog. 2016 Jan; 12(1):e1005356. Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, Brooks DG. PMID: 26808628.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    15. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I?B?. J Biol Chem. 2015 Sep 11; 290(37):22446. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K. PMID: 26362542.
      View in: PubMed   Mentions:    Fields:    
    16. Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor. Genes Dev. 2015 Sep 01; 29(17):1801-16. Arenzana TL, Schjerven H, Smale ST. PMID: 26314708.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults. PLoS One. 2015; 10(7):e0132061. Lissner MM, Thomas BJ, Wee K, Tong AJ, Kollmann TR, Smale ST. PMID: 26147648.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and I?B?. J Biol Chem. 2015 Feb 20; 290(8):4815. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K. PMID: 25713407.
      View in: PubMed   Mentions:    Fields:    
    19. Transcriptional control of inflammatory responses. Cold Spring Harb Perspect Biol. 2014 Sep 11; 6(11):a016261. Smale ST, Natoli G. PMID: 25213094.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    20. Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 2014 Oct 15; 193(8):3934-46. Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. PMID: 25194055.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Toward an understanding of the gene-specific and global logic of inducible gene transcription. Cold Spring Harb Symp Quant Biol. 2013; 78:61-8. Smale ST, Plevy SE, Weinmann AS, Zhou L, Ramirez-Carrozzi VR, Pope SD, Bhatt DM, Tong AJ. PMID: 24747344.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    22. Transcriptional regulation in the immune system: a status report. Trends Immunol. 2014 May; 35(5):190-4. Smale ST. PMID: 24703179.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression. Mol Cell Biol. 2014 Jun; 34(11):2017-28. Garcia AJ, Ruscetti M, Arenzana TL, Tran LM, Bianci-Frias D, Sybert E, Priceman SJ, Wu L, Nelson PS, Smale ST, Wu H. PMID: 24662052.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    24. Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol. 2014; 32:489-511. Smale ST, Tarakhovsky A, Natoli G. PMID: 24555473.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    25. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Nat Immunol. 2013 Oct; 14(10):1073-83. Schjerven H, McLaughlin J, Arenzana TL, Frietze S, Cheng D, Wadsworth SE, Lawson GW, Bensinger SJ, Farnham PJ, Witte ON, Smale ST. PMID: 24013668.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    26. Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression. RNA. 2013 Jun; 19(6):811-27. Pandya-Jones A, Bhatt DM, Lin CH, Tong AJ, Smale ST, Black DL. PMID: 23616639.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    27. Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood. 2013 Mar 07; 121(10):1769-82. Ferreirós-Vidal I, Carroll T, Taylor B, Terry A, Liang Z, Bruno L, Dharmalingam G, Khadayate S, Cobb BS, Smale ST, Spivakov M, Srivastava P, Petretto E, Fisher AG, Merkenschlager M. PMID: 23303821.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    28. Designing an enhancer landscape. Cell. 2012 Nov 21; 151(5):929-31. Xu J, Smale ST. PMID: 23178114.
      View in: PubMed   Mentions: 7     Fields:    
    29. Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5. Biochem Biophys Res Commun. 2013 Jan 04; 430(1):95-100. Koshiba R, Yanai H, Matsuda A, Goto A, Nakajima A, Negishi H, Nishio J, Smale ST, Taniguchi T. PMID: 23154183.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol. 2012 Oct; 13(10):916-24. Murray PJ, Smale ST. PMID: 22990889.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    31. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell. 2012 Jul 20; 150(2):279-90. Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G, Black DL, Smale ST. PMID: 22817891.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    32. Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nat Immunol. 2012 May 20; 13(7):659-66. Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T. PMID: 22610141.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    33. Dimer-specific regulatory mechanisms within the NF-?B family of transcription factors. Immunol Rev. 2012 Mar; 246(1):193-204. Smale ST. PMID: 22435556.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    34. Transcriptional regulation in the innate immune system. Curr Opin Immunol. 2012 Feb; 24(1):51-7. Smale ST. PMID: 22230561.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-?B family DNA binding. Nat Immunol. 2011 Nov 20; 13(1):95-102. Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML. PMID: 22101729.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    36. Hierarchies of NF-?B target-gene regulation. Nat Immunol. 2011 Jul 19; 12(8):689-94. Smale ST. PMID: 21772277.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    37. A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J Biol Chem. 2011 Jul 01; 286(26):23582-90. Smith AM, Qualls JE, O'Brien K, Balouzian L, Johnson PF, Schultz-Cherry S, Smale ST, Murray PJ. PMID: 21566115.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    38. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J Immunol. 2011 Apr 15; 186(8):4649-55. Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale ST, Hibi T, Rothman PB, Kashiwada M, Plevy SE. PMID: 21383239.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    39. Immune inhibitory ligand CD200 induction by TLRs and NLRs limits macrophage activation to protect the host from meningococcal septicemia. Cell Host Microbe. 2010 Sep 16; 8(3):236-47. Mukhopadhyay S, Plüddemann A, Hoe JC, Williams KJ, Varin A, Makepeace K, Aknin ML, Bowdish DM, Smale ST, Barclay AN, Gordon S. PMID: 20833375.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    40. Pioneer factors in embryonic stem cells and differentiation. Curr Opin Genet Dev. 2010 Oct; 20(5):519-26. Smale ST. PMID: 20638836.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    41. Seq-ing LPS-induced enhancers. Immunity. 2010 Mar 26; 32(3):296-8. Smale ST. PMID: 20346768.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Selective transcription in response to an inflammatory stimulus. Cell. 2010 Mar 19; 140(6):833-44. Smale ST. PMID: 20303874.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    43. Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. Genes Dev. 2009 Dec 15; 23(24):2824-38. Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST. PMID: 20008934.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    44. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009 Jul 10; 138(1):114-28. Ramirez-Carrozzi VR, Braas D, Bhatt DM, Cheng CS, Hong C, Doty KR, Black JC, Hoffmann A, Carey M, Smale ST. PMID: 19596239.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimalsCells
    45. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008 Aug; 9(8):927-36. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. PMID: 18568028.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    46. Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta. J Biol Chem. 2008 May 02; 283(18):12468-77. Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K. PMID: 18319258.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    47. Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. J Biol Chem. 2007 Oct 12; 282(41):30227-38. Sridharan R, Smale ST. PMID: 17681952.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    48. Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12377-82. Xu J, Pope SD, Jazirehi AR, Attema JL, Papathanasiou P, Watts JA, Zaret KS, Weissman IL, Smale ST. PMID: 17640912.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    49. Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12371-6. Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL. PMID: 17640913.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    50. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity. 2007 Mar; 26(3):335-44. Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M. PMID: 17363301.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    51. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment. Mol Cell Biol. 2007 Apr; 27(7):2698-712. Zhou L, Nazarian AA, Xu J, Tantin D, Corcoran LM, Smale ST. PMID: 17242186.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    52. Pursuing gene regulation 'logic' via RNA interference and chromatin immunoprecipitation. Nat Immunol. 2006 Jul; 7(7):692-7. Li CC, Ramirez-Carrozzi VR, Smale ST. PMID: 16785883.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    53. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006 Apr; 7(4):367-9. Smale ST, Dorshkind K. PMID: 16550201.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    54. Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev. 2006 Feb 01; 20(3):282-96. Ramirez-Carrozzi VR, Nazarian AA, Li CC, Gore SL, Sridharan R, Imbalzano AN, Smale ST. PMID: 16452502.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    55. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev. 2005 Sep 15; 19(18):2138-51. Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. PMID: 16166378.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    56. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. PMID: 16148093.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    57. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 02; 201(9):1367-73. Cobb BS, Nesterova TB, Thompson E, Hertweck A, O'Connor E, Godwin J, Wilson CB, Brockdorff N, Fisher AG, Smale ST, Merkenschlager M. PMID: 15867090.
      View in: PubMed   Mentions: 220     Fields:    Translation:AnimalsCells
    58. Assembly of silent chromatin during thymocyte development. Semin Immunol. 2005 Apr; 17(2):129-40. Su RC, Sridharan R, Smale ST. PMID: 15737574.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    59. Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet. 2004 May; 36(5):502-6. Su RC, Brown KE, Saaber S, Fisher AG, Merkenschlager M, Smale ST. PMID: 15098035.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    60. Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Mol Cell Biol. 2004 Mar; 24(6):2385-96. Zhou L, Nazarian AA, Smale ST. PMID: 14993278.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    61. Ikaros family members from the agnathan Myxine glutinosa and the urochordate Oikopleura dioica: emergence of an essential transcription factor for adaptive immunity. J Immunol. 2003 Dec 01; 171(11):6006-13. Cupit PM, Hansen JD, McCarty AS, White G, Chioda M, Spada F, Smale ST, Cunningham C. PMID: 14634112.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    62. Upstream of Ikaros. Trends Immunol. 2003 Nov; 24(11):567-70. Liberg D, Smale ST, Merkenschlager M. PMID: 14596876.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    63. C/EBPbeta regulation in lipopolysaccharide-stimulated macrophages. Mol Cell Biol. 2003 Jul; 23(14):4841-58. Bradley MN, Zhou L, Smale ST. PMID: 12832471.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    64. A Th2 cytokine LCR. Adding a new piece to the regulatory puzzle. Immunity. 2003 Jul; 19(1):1-2. Smale ST. PMID: 12871632.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    65. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity. 2003 Jul; 19(1):131-44. Papathanasiou P, Perkins AC, Cobb BS, Ferrini R, Sridharan R, Hoyne GF, Nelms KA, Smale ST, Goodnow CC. PMID: 12871645.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    66. The establishment and maintenance of lymphocyte identity through gene silencing. Nat Immunol. 2003 Jul; 4(7):607-15. Smale ST. PMID: 12830135.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    67. Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol. 2003 Apr; 23(7):2543-55. Ronni T, Agarwal V, Haykinson M, Haberland ME, Cheng G, Smale ST. PMID: 12640135.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    68. The RNA polymerase II core promoter. Annu Rev Biochem. 2003; 72:449-79. Smale ST, Kadonaga JT. PMID: 12651739.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansAnimalsCells
    69. Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell. 2003 Feb; 11(2):459-70. McCarty AS, Kleiger G, Eisenberg D, Smale ST. PMID: 12620233.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    70. A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev. 2002 Dec 01; 16(23):2985-90. Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST. PMID: 12464629.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    71. Chromatin structure and gene regulation in the immune system. Annu Rev Immunol. 2002; 20:427-62. Smale ST, Fisher AG. PMID: 11861609.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
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