Robert L Modlin

Title(s)Professor, Medicine
SchoolMedicine
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    Title(s)Professor, MIMG


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    Dr. Robert L. Modlin holds the Arnold W. Klein, M.D., Chair in Dermatology.
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    IL-26 in host defense against infection by intracellular bacteria in skin
    NIH R01AR073252Jul 12, 2019 - Apr 30, 2024
    Role: Principal Investigator
    The skin microbiome in acne
    NIH R01AR074302Aug 13, 2018 - May 31, 2023
    Role: Principal Investigator
    Dermatology Scientist Training Program
    NIH T32AR071307Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Modeling granuloma formation using engineered microcapsules
    NIH R21AI121779Apr 15, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Immunobiology of Leprosy
    NIH P50AR063020Aug 16, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Deriving P. acnes Bacteriophages from Skin for Acne Therapy
    NIH R21AR060382Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Danaher (Leica) TCS SP5 Confocal System
    NIH S10RR027083May 13, 2010 - May 12, 2011
    Role: Principal Investigator
    Dermatology Scientist Training Program
    NIH T32AR058921May 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Application of Novel Antigens and Integrated Microfluidics for Leprosy Diagnosis
    NIH R01AI082575Sep 28, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Role of Vitamin D Prohormone 25-OHD in the Immune Response to Tuberculosis
    NIH R01HL119068Jun 1, 2008 - Jun 30, 2018
    Role: Principal Investigator
    Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to Tuberculosis
    NIH R01AI073539Jun 1, 2008 - May 31, 2014
    Role: Principal Investigator
    GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    NIH R01AI059091Jul 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    CD1-targeted Vaccination against Tuberculosis
    NIH U01AI056489Aug 1, 2003 - Jan 31, 2008
    Role: Principal Investigator
    Divergence of Phagocytic and Antimicrobial Programs in Leprosy
    NIH R01AI047868Sep 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    ROLE OF TOLL-LIKE RECEPTORS IN SKIN
    NIH R37AI047868Sep 1, 2000 - Feb 28, 2010
    Role: Principal Investigator
    LOCAL T-CELL RESPONSE IN HUMAN LEISHMANIASIS
    NIH R01AI034032Sep 30, 1996 - Aug 31, 2000
    Role: Principal Investigator
    MODULATION OF T CELL RESPONSES IN TB AND HIV INFECTION
    NIH R01AI036069Sep 1, 1994 - May 31, 1999
    Role: Principal Investigator
    T-CELL AND CYTOKINE PATTERNS IN CUTANEOUS CARCINOMA
    NIH R01CA056860Apr 1, 1992 - Mar 31, 1995
    Role: Principal Investigator
    CD1-restricted T-cell Responses in Skin
    NIH R01AR040312Mar 1, 1990 - Jul 31, 2026
    Role: Principal Investigator
    Molecular Analysis of Host Immune Response in Leprosy
    NIH R01AI022553Apr 1, 1986 - Jun 30, 2024
    Role: Principal Investigator
    IMMUNOREGULATORY T-LYMPHOCYTES IN LEPROSY SKIN LESIONS
    NIH R22AI022553Apr 1, 1986 - Jun 30, 1993
    Role: Principal Investigator
    IMMUNOREGULATION IN LEPROSY GRANULOMAS
    NIH R23AI022187Sep 1, 1985 - Aug 31, 1988
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics. EBioMedicine. 2024 Oct; 108:105342. Mi Z, Wang Z, Wang Y, Xue X, Liao X, Wang C, Sun L, Lin Y, Wang J, Guo D, Liu T, Liu J, Modlin RL, Liu H, Zhang F. PMID: 39321499; PMCID: PMC11462173.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Putative pseudolysogeny-dependent phage gene implicated in the superinfection resistance of Cutibacterium acnes. Microbiome Res Rep. 2024; 3(3):27. Wottrich S, Mendonca S, Safarpour C, Nguyen C, Marinelli LJ, Hancock SP, Modlin RL, Parker JM. PMID: 39421248; PMCID: PMC11480721.
      View in: PubMed   Mentions:
    3. Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26. J Exp Med. 2024 May 06; 221(5). Baldo A, Di Domizio J, Yatim A, Vandenberghe-Dürr S, Jenelten R, Fries A, Grizzetti L, Kuonen F, Paul C, Modlin RL, Conrad C, Gilliet M. PMID: 38448036; PMCID: PMC10917069.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa. J Clin Invest. 2024 Feb 01; 134(3). van Straalen KR, Ma F, Tsou PS, Plazyo O, Gharaee-Kermani M, Calbet M, Xing X, Sarkar MK, Uppala R, Harms PW, Wasikowski R, Nahlawi L, Nakamura M, Eshaq M, Wang C, Dobry C, Kozlow JH, Cherry-Bukowiec J, Brodie WD, Wolk K, Uluçkan Ö, Mattichak MN, Pellegrini M, Modlin RL, Maverakis E, Sabat R, Kahlenberg JM, Billi AC, Tsoi LC, Gudjonsson JE. PMID: 38051587; PMCID: PMC10836805.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Microbes, Autoimmunity, and Cancer: 69th Annual Montagna Symposium on the Biology of Skin. J Invest Dermatol. 2024 Jun; 144(6):1184-1185.e1. Modlin RL, Anandasabapathy N, Kaplan D, O'Shea J, Roop D, Leachman S. PMID: 38300199.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Immunobiology of IL-26. J Invest Dermatol. 2024 Jun; 144(6):1217-1222. Gilliet M, Modlin RL. PMID: 38206272.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis. Nat Commun. 2024 Jan 03; 15(1):210. Ma F, Tsou PS, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. PMID: 38172207; PMCID: PMC10764940.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. IFN-γ-mediated control of SARS-CoV-2 infection through nitric oxide. Front Immunol. 2023; 14:1284148. Silva BJA, Krogstad PA, Teles RMB, Andrade PR, Rajfer J, Ferrini MG, Yang OO, Bloom BR, Modlin RL. PMID: 38162653; PMCID: PMC10755032.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis. JCI Insight. 2023 08 22; 8(16). Xing E, Ma F, Wasikowski R, Billi AC, Gharaee-Kermani M, Fox J, Dobry C, Victory A, Sarkar MK, Xing X, Plazyo O, Chen HW, Barber G, Jacobe H, Tsou PS, Modlin RL, Varga J, Kahlenberg JM, Tsoi LC, Gudjonsson JE, Khanna D. PMID: 37471168; PMCID: PMC10543736.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab. J Allergy Clin Immunol. 2024 01; 153(1):146-160. Ma F, Gharaee-Kermani M, Tsoi LC, Plazyo O, Chaskar P, Harms P, Patrick MT, Xing X, Hile G, Piketty C, Lazzari A, Van Delm W, Maverakis E, Nakamura M, Modlin RL, Kahlenberg JM, Billi AC, Julia V, Krishnaswamy JK, Gudjonsson JE. PMID: 37506977; PMCID: PMC11231883.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. Genetic and Functional Analyses of Cutibacterium Acnes Isolates Reveal the Association of a Linear Plasmid with Skin Inflammation. J Invest Dermatol. 2024 01; 144(1):116-124.e4. O'Neill AM, Cavagnero KJ, Seidman JS, Zaramela L, Chen Y, Li F, Nakatsuji T, Cheng JY, Tong YL, Do TH, Brinton SL, Hata TR, Modlin RL, Gallo RL. PMID: 37478901; PMCID: PMC11137742.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis. Nat Commun. 2023 06 30; 14(1):3878. Fries A, Saidoune F, Kuonen F, Dupanloup I, Fournier N, Guerra de Souza AC, Haniffa M, Ma F, Gudjonsson JE, Roesner L, Li Y, Werfel T, Conrad C, Gottardo R, Modlin RL, Di Domizio J, Gilliet M. PMID: 37391412; PMCID: PMC10313793.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis. Nat Commun. 2023 06 12; 14(1):3455. Ma F, Plazyo O, Billi AC, Tsoi LC, Xing X, Wasikowski R, Gharaee-Kermani M, Hile G, Jiang Y, Harms PW, Xing E, Kirma J, Xi J, Hsu JE, Sarkar MK, Chung Y, Di Domizio J, Gilliet M, Ward NL, Maverakis E, Klechevsky E, Voorhees JJ, Elder JT, Lee JH, Kahlenberg JM, Pellegrini M, Modlin RL, Gudjonsson JE. PMID: 37308489; PMCID: PMC10261041.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    14. CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses. Science. 2023 02 17; 379(6633):eabg2752. He M, Roussak K, Ma F, Borcherding N, Garin V, White M, Schutt C, Jensen TI, Zhao Y, Iberg CA, Shah K, Bhatia H, Korenfeld D, Dinkel S, Gray J, Ulezko Antonova A, Ferris S, Donermeyer D, Lindestam Arlehamn C, Gubin MM, Luo J, Gorvel L, Pellegrini M, Sette A, Tung T, Bak R, Modlin RL, Fields RC, Schreiber RD, Allen PM, Klechevsky E. PMID: 36795805; PMCID: PMC10424698.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    15. Human lung-resident mucosal-associated invariant T cells are abundant, express antimicrobial proteins, and are cytokine responsive. Commun Biol. 2022 09 09; 5(1):942. Meermeier EW, Zheng CL, Tran JG, Soma S, Worley AH, Weiss DI, Modlin RL, Swarbrick G, Karamooz E, Khuzwayo S, Wong EB, Gold MC, Lewinsohn DM. PMID: 36085311; PMCID: PMC9463188.
      View in: PubMed   Mentions: 7  Translation:HumansCells
    16. TREM2 macrophages induced by human lipids drive inflammation in acne lesions. Sci Immunol. 2022 07 22; 7(73):eabo2787. Do TH, Ma F, Andrade PR, Teles R, de Andrade Silva BJ, Hu C, Espinoza A, Hsu JE, Cho CS, Kim M, Xi J, Xing X, Plazyo O, Tsoi LC, Cheng C, Kim J, Bryson BD, O'Neill AM, Colonna M, Gudjonsson JE, Klechevsky E, Lee JH, Gallo RL, Bloom BR, Pellegrini M, Modlin RL. PMID: 35867799; PMCID: PMC9400695.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    17. Nonlesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation. Sci Transl Med. 2022 04 27; 14(642):eabn2263. Billi AC, Ma F, Plazyo O, Gharaee-Kermani M, Wasikowski R, Hile GA, Xing X, Yee CM, Rizvi SM, Maz MP, Berthier CC, Wen F, Tsoi LC, Pellegrini M, Modlin RL, Gudjonsson JE, Kahlenberg JM. PMID: 35476593; PMCID: PMC9169615.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    18. Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne. Sci Transl Med. 2022 02 16; 14(632):eabh1478. O'Neill AM, Liggins MC, Seidman JS, Do TH, Li F, Cavagnero KJ, Dokoshi T, Cheng JY, Shafiq F, Hata TR, Gudjonsson JE, Modlin RL, Gallo RL. PMID: 35171653; PMCID: PMC9885891.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Noninvasive Tape-Stripping with High-Resolution RNA Profiling Effectively Captures a Preinflammatory State in Nonlesional Psoriatic Skin. J Invest Dermatol. 2022 06; 142(6):1587-1596.e2. Tsoi LC, Xing X, Xing E, Wasikowski R, Shao S, Zeng C, Plazyo O, Kirma J, Jiang Y, Billi AC, Sarkar MK, Turnier JL, Uppala R, Smith KM, Helfrich Y, Voorhees JJ, Maverakis E, Modlin RL, Kahlenberg JM, Scott VE, Gudjonsson JE. PMID: 34808239; PMCID: PMC9117571.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells. Front Immunol. 2021; 12:695373. Oulee A, Ma F, Teles RMB, de Andrade Silva BJ, Pellegrini M, Klechevsky E, Harman AN, Rhodes JW, Modlin RL. PMID: 34512625; PMCID: PMC8426439.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 2021 07; 22(7):839-850. Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, Tsoi LC, Do T, Wadsworth MH, Oulee A, Ochoa MT, Sarno EN, Iruela-Arispe ML, Klechevsky E, Bryson B, Shalek AK, Bloom BR, Gudjonsson JE, Pellegrini M, Modlin RL. PMID: 34168371; PMCID: PMC8579511.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    22. IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses. J Invest Dermatol. 2021 10; 141(10):2436-2448. Shao S, Tsoi LC, Swindell WR, Chen J, Uppala R, Billi AC, Xing X, Zeng C, Sarkar MK, Wasikowski R, Jiang Y, Kirma J, Sun J, Plazyo O, Wang G, Harms PW, Voorhees JJ, Ward NL, Ma F, Pellegrini M, Merleev A, Perez White BE, Modlin RL, Andersen B, Maverakis E, Weidinger S, Kahlenberg JM, Gudjonsson JE. PMID: 33864770; PMCID: PMC9423738.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. A CD4+CD161+ T-Cell Subset Present in Unexposed Humans, Not Tb Patients, Are Fast Acting Cells That Inhibit the Growth of Intracellular Mycobacteria Involving CD161 Pathway, Perforin, and IFN-γ/Autophagy. Front Immunol. 2021; 12:599641. Yang R, Peng Y, Pi J, Liu Y, Yang E, Shen X, Yao L, Shen L, Modlin RL, Shen H, Sha W, Chen ZW. PMID: 33732233; PMCID: PMC7959736.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    24. Extracellular traps released by antimicrobial TH17 cells contribute to host defense. J Clin Invest. 2021 01 19; 131(2). Agak GW, Mouton A, Teles RM, Weston T, Morselli M, Andrade PR, Pellegrini M, Modlin RL. PMID: 33211671; PMCID: PMC7810473.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. Immunity. 2020 10 13; 53(4):878-894.e7. Hughes TK, Wadsworth MH, Gierahn TM, Do T, Weiss D, Andrade PR, Ma F, de Andrade Silva BJ, Shao S, Tsoi LC, Ordovas-Montanes J, Gudjonsson JE, Modlin RL, Love JC, Shalek AK. PMID: 33053333; PMCID: PMC7562821.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    26. Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight. 2020 10 02; 5(19). Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen ARJV, van der Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow JH, Cherry-Bukowiec JR, Jiang Y, Kirma J, Weidinger S, Cushing KC, Rosenblum MD, Berthier C, MacLeod AS, Voorhees JJ, Wen F, Kahlenberg JM, Maverakis E, Modlin RL, Prens EP. PMID: 32853177; PMCID: PMC7566715.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    27. IL-32γ potentiates tumor immunity in melanoma. JCI Insight. 2020 09 17; 5(18). Gruber T, Kremenovic M, Sadozai H, Rombini N, Baeriswyl L, Maibach F, Modlin RL, Gilliet M, von Werdt D, Hunger RE, Seyed Jafari SM, Parisi G, Abril-Rodriguez G, Ribas A, Schenk M. PMID: 32841222; PMCID: PMC7526542.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ. iScience. 2020 May 22; 23(5):101050. Kelly-Scumpia KM, Choi A, Shirazi R, Bersabe H, Park E, Scumpia PO, Ochoa MT, Yu J, Ma F, Pellegrini M, Modlin RL. PMID: 32339990; PMCID: PMC7190750.
      View in: PubMed   Mentions: 5  
    29. Cellular, Molecular, and Immunological Characteristics of Langhans Multinucleated Giant Cells Programmed by IL-15. J Invest Dermatol. 2020 09; 140(9):1824-1836.e7. Wang H, Jiang H, Teles RMB, Chen Y, Wu A, Lu J, Chen Z, Ma F, Pellegrini M, Modlin RL. PMID: 32092350; PMCID: PMC8223586.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection. Immune Netw. 2020 Apr; 20(2):e12. Chung C, Silwal P, Kim I, Modlin RL, Jo EK. PMID: 32395364; PMCID: PMC7192829.
      View in: PubMed   Mentions: 53  
    31. Response to Comment on "IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells". J Immunol. 2019 12 15; 203(12):3093. Modlin RL. PMID: 31818921.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    32. Whole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study. Sci Rep. 2019 11 29; 9(1):17931. Tió-Coma M, van Hooij A, Bobosha K, van der Ploeg-van Schip JJ, Banu S, Khadge S, Thapa P, Kunwar CB, Goulart IM, Bekele Y, Hagge DA, Moraes MO, Teles RMB, Pinheiro RO, van Zwet EW, Goeman JJ, Aseffa A, Haks MC, Ottenhoff THM, Modlin RL, Geluk A. PMID: 31784594; PMCID: PMC6884598.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction. PLoS Negl Trop Dis. 2019 10; 13(10):e0007764. Teles RMB, Lu J, Tió-Coma M, Goulart IMB, Banu S, Hagge D, Bobosha K, Ottenhoff THM, Pellegrini M, Geluk A, Modlin RL. PMID: 31600201; PMCID: PMC6805014.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    34. Correction: IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. J Immunol. 2019 Oct 01; 203(7):2020. Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW. PMID: 31471522.
      View in: PubMed   Mentions:    Fields:    
    35. Corrigendum: IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth. Front Immunol. 2019; 10:1742. Yang R, Yao L, Shen L, Sha W, Modlin RL, Shen H, Chen ZW. PMID: 31404161; PMCID: PMC6677117.
      View in: PubMed   Mentions: 1     Fields:    
    36. The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Negl Trop Dis. 2019 07; 13(7):e0007589. R Andrade P, Mehta M, Lu J, M B Teles R, Montoya D, O Scumpia P, Nunes Sarno E, Ochoa MT, Ma F, Pellegrini M, Modlin RL. PMID: 31344041; PMCID: PMC6684084.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells. J Immunol. 2019 08 15; 203(4):911-921. Weiss DI, Ma F, Merleev AA, Maverakis E, Gilliet M, Balin SJ, Bryson BD, Ochoa MT, Pellegrini M, Bloom BR, Modlin RL. PMID: 31235553; PMCID: PMC6684376.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    38. Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis. mSphere. 2019 06 05; 4(3). Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT. PMID: 31167948; PMCID: PMC6553556.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    39. Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis. Nat Commun. 2019 05 27; 10(1):2329. Bryson BD, Rosebrock TR, Tafesse FG, Itoh CY, Nibasumba A, Babunovic GH, Corleis B, Martin C, Keegan C, Andrade P, Realegeno S, Kwon D, Modlin RL, Fortune SM. PMID: 31133636; PMCID: PMC6536549.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    40. IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth. Front Immunol. 2019; 10:913. Yang R, Yao L, Shen L, Sha W, Modlin RL, Shen H, Chen ZW. PMID: 31080452; PMCID: PMC6497761.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    41. Autophagy links antimicrobial activity with antigen presentation in Langerhans cells. JCI Insight. 2019 04 18; 4(8). Dang AT, Teles RM, Liu PT, Choi A, Legaspi A, Sarno EN, Ochoa MT, Parvatiyar K, Cheng G, Gilliet M, Bloom BR, Modlin RL. PMID: 30996142; PMCID: PMC6538337.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. IL-26 contributes to host defense against intracellular bacteria. J Clin Invest. 2019 04 02; 129(5):1926-1939. Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL. PMID: 30939123; PMCID: PMC6486355.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    43. Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions. Sci Rep. 2019 03 27; 9(1):5288. Cheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin RL, Hoffmann A. PMID: 30918279; PMCID: PMC6437173.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    44. Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response. Cell Rep. 2019 03 26; 26(13):3574-3585.e3. Montoya DJ, Andrade P, Silva BJA, Teles RMB, Ma F, Bryson B, Sadanand S, Noel T, Lu J, Sarno E, Arnvig KB, Young D, Lahiri R, Williams DL, Fortune S, Bloom BR, Pellegrini M, Modlin RL. PMID: 30917313; PMCID: PMC6508871.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    45. Plasticity of antimicrobial and phagocytic programs in human macrophages. Immunology. 2019 02; 156(2):164-173. Montoya D, Mehta M, Ferguson BG, Teles RMB, Krutzik SR, Cruz D, Pellegrini M, Modlin RL. PMID: 30357820; PMCID: PMC6328994.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    46. A phylogenomic study quantifies competing mechanisms for pseudogenization in prokaryotes-The Mycobacterium leprae case. PLoS One. 2018; 13(11):e0204322. Avni E, Montoya D, Lopez D, Modlin R, Pellegrini M, Snir S. PMID: 30383852; PMCID: PMC6211624.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    47. Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN. PLoS Negl Trop Dis. 2018 10; 12(10):e0006815. Zavala K, Gottlieb CA, Teles RM, Adams JS, Hewison M, Modlin RL, Liu PT. PMID: 30300363; PMCID: PMC6177120.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    48. Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 08 31; 3(26). Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. PMID: 30171080; PMCID: PMC6431239.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    49. Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae. PLoS Negl Trop Dis. 2018 07; 12(7):e0006608. Kim EW, Teles RMB, Haile S, Liu PT, Modlin RL. PMID: 29965969; PMCID: PMC6044553.
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    50. Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network. J Immunol. 2018 05 01; 200(9):3244-3258. Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL. PMID: 29610140; PMCID: PMC5916334.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    51. Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages. BMC Microbiol. 2018 03 01; 18(1):19. Cheng L, Marinelli LJ, Grosset N, Fitz-Gibbon ST, Bowman CA, Dang BQ, Russell DA, Jacobs-Sera D, Shi B, Pellegrini M, Miller JF, Gautier M, Hatfull GF, Modlin RL. PMID: 29490612; PMCID: PMC5831693.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    52. IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. J Immunol. 2018 04 01; 200(7):2405-2417. Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW. PMID: 29453279; PMCID: PMC5860987.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    53. SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles. BMC Genomics. 2017 Oct 25; 18(1):824. Lopez D, Montoya D, Ambrose M, Lam L, Briscoe L, Adams C, Modlin RL, Pellegrini M. PMID: 29070035; PMCID: PMC5657101.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    54. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 2017 Aug 24; 170(5):973-985.e10. Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. PMID: 28841420; PMCID: PMC5848073.
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    55. Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS Pathog. 2017 Jul; 13(7):e1006496. Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST. PMID: 28704551; PMCID: PMC5526579.
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    56. Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host Microbe. 2017 Mar 08; 21(3):334-343. Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX, Cheng G. PMID: 28279345.
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    57. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight. 2016 09 22; 1(15):e88843. Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL. PMID: 27699251; PMCID: PMC5033757.
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    58. Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae. Infect Immun. 2016 09; 84(9):2429-38. Schenk M, Mahapatra S, Le P, Kim HJ, Choi AW, Brennan PJ, Belisle JT, Modlin RL. PMID: 27297389; PMCID: PMC4995902.
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    59. Jagged1 Instructs Macrophage Differentiation in Leprosy. PLoS Pathog. 2016 08; 12(8):e1005808. Kibbie J, Teles RM, Wang Z, Hong P, Montoya D, Krutzik S, Lee S, Kwon O, Modlin RL, Cruz D. PMID: 27532668; PMCID: PMC4988718.
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    60. Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nat Commun. 2016 08 01; 7:12348. Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A. PMID: 27476449; PMCID: PMC4974650.
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    61. Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis. Am J Respir Crit Care Med. 2016 08 01; 194(3):345-55. Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S, TBornotTB Network. PMID: 26882070; PMCID: PMC5441105.
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    62. Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes. J Invest Dermatol. 2016 11; 136(11):2221-2228. Yu Y, Champer J, Agak GW, Kao S, Modlin RL, Kim J. PMID: 27377696; PMCID: PMC8295477.
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    63. S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS Pathog. 2016 06; 12(6):e1005705. Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL. PMID: 27355424; PMCID: PMC4927120.
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    64. Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages. Microbiol Spectr. 2016 06; 4(3). Bloom BR, Modlin RL. PMID: 27337485.
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    65. Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages. J Immunol. 2016 07 01; 197(1):222-32. Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M. PMID: 27233968; PMCID: PMC5536119.
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    66. Thomas Herald Rea, MD (1929-2016). Lepr Rev. 2016 Mar; 87(1):130-1. Ochoa MT, Vaccaro S, Jerskey R, Mora H, Peng D, Modlin RL. PMID: 27255071.
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    67. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15408-13. Demaria O, De Gassart A, Coso S, Gestermann N, Di Domizio J, Flatz L, Gaide O, Michielin O, Hwu P, Petrova TV, Martinon F, Modlin RL, Speiser DE, Gilliet M. PMID: 26607445; PMCID: PMC4687570.
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    68. T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol. 2015 Sep; 16(9):970-9. Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M. PMID: 26168081; PMCID: PMC4776746.
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    69. IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol. 2015 Oct; 135(10):2410-2417. Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL. PMID: 26030183; PMCID: PMC4567935.
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    70. Combinatorial code governing cellular responses to complex stimuli. Nat Commun. 2015 Apr 21; 6:6847. Cappuccio A, Zollinger R, Schenk M, Walczak A, Servant N, Barillot E, Hupé P, Modlin RL, Soumelis V. PMID: 25896517; PMCID: PMC4410637.
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    71. Bee venom processes human skin lipids for presentation by CD1a. J Exp Med. 2015 Feb 09; 212(2):149-63. Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G. PMID: 25584012; PMCID: PMC4322046.
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    72. Carbohydrate-dependent binding of langerin to SodC, a cell wall glycoprotein of Mycobacterium leprae. J Bacteriol. 2015 Feb; 197(3):615-25. Kim HJ, Brennan PJ, Heaslip D, Udey MC, Modlin RL, Belisle JT. PMID: 25422308; PMCID: PMC4285976.
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    73. IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci Transl Med. 2014 Aug 20; 6(250):250ra114. Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL. PMID: 25143364; PMCID: PMC4175914.
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    74. Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis. J Invest Dermatol. 2015 Jan; 135(1):151-159. Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M. PMID: 25111617; PMCID: PMC4268388.
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    75. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014; 5:151. Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. PMID: 24795646; PMCID: PMC4000998.
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    76. Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology. 2014 Feb; 141(2):174-80. Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, Montoya D, Liu PT, Modlin RL. PMID: 24032597; PMCID: PMC3904238.
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    77. TB or not TB: that is no longer the question. Sci Transl Med. 2013 Nov 27; 5(213):213sr6. Modlin RL, Bloom BR. PMID: 24285487.
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    78. CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes. Immunology. 2013 May; 139(1):121-8. Klug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M. PMID: 23289765; PMCID: PMC3634544.
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    79. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science. 2013 Mar 22; 339(6126):1448-53. Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL. PMID: 23449998; PMCID: PMC3653587.
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    80. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013 Sep; 133(9):2152-60. Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, Modlin RL, Miller JF, Sodergren E, Craft N, Weinstock GM, Li H. PMID: 23337890; PMCID: PMC3745799.
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    81. Galectin-3 regulates the innate immune response of human monocytes. J Infect Dis. 2013 Mar 15; 207(6):947-56. Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Rea TH, Stenger S, Modlin RL, Lee DJ. PMID: 23255567; PMCID: PMC3571442.
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    82. Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. J Invest Dermatol. 2013 May; 133(5):1231-9. Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J. PMID: 23190896; PMCID: PMC3631294.
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    83. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol. 2012 Dec; 13(12):1155-61. Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. PMID: 23142775; PMCID: PMC3501571.
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    84. On the nature of mycobacteriophage diversity and host preference. Virology. 2012 Dec 20; 434(2):187-201. Jacobs-Sera D, Marinelli LJ, Bowman C, Broussard GW, Guerrero Bustamante C, Boyle MM, Petrova ZO, Dedrick RM, Pope WH, Science Education Alliance Phage Hunters Advancing Genomics And Evolutionary Science Sea-Phages Prog, Modlin RL, Hendrix RW, Hatfull GF. PMID: 23084079; PMCID: PMC3518647.
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    85. Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. mBio. 2012; 3(5). Marinelli LJ, Fitz-Gibbon S, Hayes C, Bowman C, Inkeles M, Loncaric A, Russell DA, Jacobs-Sera D, Cokus S, Pellegrini M, Kim J, Miller JF, Hatfull GF, Modlin RL. PMID: 23015740; PMCID: PMC3448167.
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    86. Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages. J Immunol. 2012 Oct 15; 189(8):4069-78. Bruns H, Stegelmann F, Fabri M, Döhner K, van Zandbergen G, Wagner M, Skinner M, Modlin RL, Stenger S. PMID: 22988030; PMCID: PMC3684563.
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    87. Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood. 2012 Nov 01; 120(18):3699-707. Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M. PMID: 22927244; PMCID: PMC3488884.
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    88. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 2012 Aug; 22(8):1118-27. Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D. PMID: 22534567; PMCID: PMC3382347.
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    89. NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med. 2012 Mar 25; 18(4):555-63. Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. PMID: 22447076; PMCID: PMC3348859.
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    90. A review of the Journal of Investigative Dermatology's most cited publications over the past 25 years and the use of developing bibliometric methodologies to assess journal quality. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):1050-60. Bickers DR, Modlin RL. PMID: 22330274; PMCID: PMC4430846.
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    91. Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells. Blood. 2012 Mar 29; 119(13):3128-31. Hou W, Gibbs JS, Lu X, Brooke CB, Roy D, Modlin RL, Bennink JR, Yewdell JW. PMID: 22310910; PMCID: PMC3321872.
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    92. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012 Jan 29; 18(2):267-73. Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL. PMID: 22286305; PMCID: PMC3274599.
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    93. Innate immunity: ignored for decades, but not forgotten. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):882-6. Modlin RL. PMID: 22158552; PMCID: PMC3279620.
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    94. Shedding light on the vitamin D-tuberculosis-HIV connection. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):18861-2. Realegeno S, Modlin RL. PMID: 22084116; PMCID: PMC3223477.
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    95. Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12; 3(104):104ra102. Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. PMID: 21998409; PMCID: PMC3269210.
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    96. Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses. J Biol Chem. 2011 Oct 14; 286(41):35438-35446. Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MVS, Stenger S, Modlin RL, Schlesinger LS. PMID: 21859718; PMCID: PMC3195570.
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    97. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab. 2011 Jun; 96(6):1835-43. Walker VP, Zhang X, Rastegar I, Liu PT, Hollis BW, Adams JS, Modlin RL. PMID: 21470993; PMCID: PMC3100757.
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    98. Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6769-74. Cruz D, Wang Z, Kibbie J, Modlin R, Kwon O. PMID: 21383121; PMCID: PMC3084088.
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    99. Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections. J Invest Dermatol. 2011 Apr; 131(4):907-15. Cho JS, Zussman J, Donegan NP, Ramos RI, Garcia NC, Uslan DZ, Iwakura Y, Simon SI, Cheung AL, Modlin RL, Kim J, Miller LS. PMID: 21191403; PMCID: PMC3059384.
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    100. Editorial overview. Curr Opin Immunol. 2011 Feb; 23(1):1-2. Glimcher LH, Martinon F, Modlin RL. PMID: 21185707.
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    101. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22593-8. Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL. PMID: 21149724; PMCID: PMC3012480.
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    102. Role of autophagy in the host response to microbial infection and potential for therapy. Curr Opin Immunol. 2011 Feb; 23(1):65-70. Fabri M, Realegeno SE, Jo EK, Modlin RL. PMID: 21071195; PMCID: PMC3042547.
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    103. A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy. Immunology. 2010 Nov; 131(3):405-14. Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ. PMID: 20561085; PMCID: PMC2996561.
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    104. Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Infect Immun. 2010 Nov; 78(11):4634-43. Teles RM, Krutzik SR, Ochoa MT, Oliveira RB, Sarno EN, Modlin RL. PMID: 20713631; PMCID: PMC2976321.
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    105. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell Microbiol. 2010 Nov; 12(11):1648-65. Shin DM, Yuk JM, Lee HM, Lee SH, Son JW, Harding CV, Kim JM, Modlin RL, Jo EK. PMID: 20560977; PMCID: PMC2970753.
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    106. Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab. 2010 Jul; 95(7):3368-76. Chun RF, Lauridsen AL, Suon L, Zella LA, Pike JW, Modlin RL, Martineau AR, Wilkinson RJ, Adams J, Hewison M. PMID: 20427486; PMCID: PMC2928899.
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    107. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010 May; 120(5):1762-73. Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS. PMID: 20364087; PMCID: PMC2860944.
      View in: PubMed   Mentions: 335     Fields:    Translation:AnimalsCells
    108. Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis. 2010 Feb 15; 201(4):558-69. Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL. PMID: 20070238; PMCID: PMC2811231.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    109. The innate immune response in leprosy. Curr Opin Immunol. 2010 Feb; 22(1):48-54. Modlin RL. PMID: 20060279; PMCID: PMC2882026.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    110. Learning from leprosy: insight into the human innate immune response. Adv Immunol. 2010; 105:1-24. Montoya D, Modlin RL. PMID: 20510728.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    111. TLR2 looks at lipoproteins. Immunity. 2009 Dec 18; 31(6):847-9. Schenk M, Belisle JT, Modlin RL. PMID: 20064441.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    112. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009 Oct 22; 6(4):343-53. Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. PMID: 19837374; PMCID: PMC2764558.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    113. A vitamin for autophagy. Cell Host Microbe. 2009 Sep 17; 6(3):201-3. Fabri M, Modlin RL. PMID: 19748462.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    114. T cell responses in microbial infection. Curr Opin Immunol. 2009 Aug; 21(4):365-6. Modlin RL, Brenner MB. PMID: 19643590.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    115. Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses. J Immunol. 2009 Aug 15; 183(4):2349-55. Tanaka M, Krutzik SR, Sieling PA, Lee DJ, Rea TH, Modlin RL. PMID: 19635920; PMCID: PMC2790276.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    116. Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol. 2009 Jul 01; 183(1):491-8. Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT. PMID: 19542460; PMCID: PMC2772066.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    117. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One. 2009 Jun 05; 4(6):e5810. Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL. PMID: 19503839; PMCID: PMC2686169.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    118. The vitamin D connection to pediatric infections and immune function. Pediatr Res. 2009 May; 65(5 Pt 2):106R-113R. Walker VP, Modlin RL. PMID: 19190532; PMCID: PMC2925470.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    119. Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans. J Clin Invest. 2009 May; 119(5):1167-77. Bruns H, Meinken C, Schauenberg P, Härter G, Kern P, Modlin RL, Antoni C, Stenger S. PMID: 19381021; PMCID: PMC2673881.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansCells
    120. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009 Apr 01; 182(7):4289-95. Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. PMID: 19299728; PMCID: PMC2683618.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansCells
    121. DNA transportation authority. Nat Med. 2008 Dec; 14(12):1319-20. Lee DJ, Modlin RL. PMID: 19057557; PMCID: PMC2772991.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    122. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol. 2008 Nov 15; 181(10):7115-20. Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, Modlin RL. PMID: 18981132; PMCID: PMC2678236.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    123. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118; PMCID: PMC2467381.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    124. Human macrophage host defense against Mycobacterium tuberculosis. Curr Opin Immunol. 2008 Aug; 20(4):371-6. Liu PT, Modlin RL. PMID: 18602003.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    125. Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation. J Immunol. 2008 May 01; 180(9):5833-42. Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL. PMID: 18424702; PMCID: PMC2710377.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    126. "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages. J Invest Dermatol. 2008 Sep; 128(9):2225-31. Ochoa MT, Loncaric A, Krutzik SR, Becker TC, Modlin RL. PMID: 18337829; PMCID: PMC2682223.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    127. LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15; 179(12):8128-36. Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. PMID: 18056355; PMCID: PMC2650749.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    128. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V20-4. Adams JS, Chen H, Chun R, Ren S, Wu S, Gacad M, Nguyen L, Ride J, Liu P, Modlin R, Hewison M. PMID: 18290716.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    129. Angiogenesis in cutaneous lesions of leprosy: implications for treatment. Arch Dermatol. 2007 Dec; 143(12):1527-9. Bhandarkar SS, Cohen C, Kuruvila M, Rea TH, Mackelfresh JB, Lee DJ, Modlin RL, Arbiser JL. PMID: 18087002.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    130. Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol. 2007 Nov 15; 179(10):6933-42. Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL. PMID: 17982084.
      View in: PubMed   Mentions: 178     Fields:    Translation:AnimalsCells
    131. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007 Aug 15; 179(4):2060-3. Liu PT, Stenger S, Tang DH, Modlin RL. PMID: 17675463.
      View in: PubMed   Mentions: 337     Fields:    Translation:HumansCells
    132. Vitamin D in defense of the human immune response. Ann N Y Acad Sci. 2007 Nov; 1117:94-105. Adams JS, Liu PT, Chun R, Modlin RL, Hewison M. PMID: 17656563.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    133. Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences. Immunology. 2007 Dec; 122(4):522-31. Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL. PMID: 17635609; PMCID: PMC2266034.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    134. The vitamin D receptor and its role in inflammation and host defence: interview with Dr Robert Modlin by Emma Quigley. Expert Opin Ther Targets. 2007 Apr; 11(4):431-3. Modlin R. PMID: 17373873.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    135. Toll-like receptors in the skin. Semin Immunopathol. 2007 Apr; 29(1):15-26. Miller LS, Modlin RL. PMID: 17621951.
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    136. Regulation of human T-cell homing receptor expression in cutaneous bacterial infection. Immunology. 2007 Apr; 120(4):518-25. Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL. PMID: 17343614; PMCID: PMC2265905.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    137. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):316-21. Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P, Modlin RL, Adams JS. PMID: 17368179.
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    138. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest. 2007 Mar; 117(3):803-11. Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D, Helfrich YR, Kang S, Elalieh HZ, Steinmeyer A, Zügel U, Bikle DD, Modlin RL, Gallo RL. PMID: 17290304; PMCID: PMC1784003.
      View in: PubMed   Mentions: 266     Fields:    Translation:HumansAnimalsCells
    139. Therapeutic implications of the TLR and VDR partnership. Trends Mol Med. 2007 Mar; 13(3):117-24. Liu PT, Krutzik SR, Modlin RL. PMID: 17276732.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    140. Human keratinocyte Toll-like receptors promote distinct immune responses. J Invest Dermatol. 2007 Feb; 127(2):262-3. Miller LS, Modlin RL. PMID: 17228303.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    141. Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization. J Immunol. 2007 Feb 01; 178(3):1829-34. Di Nardo A, Braff MH, Taylor KR, Na C, Granstein RD, McInturff JE, Krutzik S, Modlin RL, Gallo RL. PMID: 17237433.
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    142. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity. 2007 Jan; 26(1):117-29. Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, Modlin RL, Liblau RS, Gressner AM, Kaufmann SH. PMID: 17239632.
      View in: PubMed   Mentions: 176     Fields:    Translation:AnimalsCells
    143. Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion. Immunology. 2007 Mar; 120(3):354-61. Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL. PMID: 17140401; PMCID: PMC2265884.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    144. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. J Exp Med. 2006 Nov 27; 203(12):2589-602. Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. PMID: 17074929; PMCID: PMC2118146.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    145. Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells. J Immunol. 2006 Oct 15; 177(8):5226-35. Im JS, Tapinos N, Chae GT, Illarionov PA, Besra GS, DeVries GH, Modlin RL, Sieling PA, Rambukkana A, Porcelli SA. PMID: 17015708.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    146. Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol. 2006 Aug 01; 177(3):1864-71. Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. PMID: 16849498.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    147. TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006 Jul 01; 177(1):298-305. Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL. PMID: 16785525.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    148. Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation. J Immunol. 2006 Mar 15; 176(6):3536-47. Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED. PMID: 16517722.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    149. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. PMID: 16497887.
      View in: PubMed   Mentions: 1455     Fields:    Translation:HumansCells
    150. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity. 2006 Jan; 24(1):79-91. Miller LS, O'Connell RM, Gutierrez MA, Pietras EM, Shahangian A, Gross CE, Thirumala A, Cheung AL, Cheng G, Modlin RL. PMID: 16413925.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    151. Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis. J Immunol. 2005 Dec 01; 175(11):7474-83. Stegelmann F, Bastian M, Swoboda K, Bhat R, Kiessler V, Krensky AM, Roellinghoff M, Modlin RL, Stenger S. PMID: 16301655.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    152. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. J Invest Dermatol. 2005 Aug; 125(2):256-63. McInturff JE, Wang SJ, Machleidt T, Lin TR, Oren A, Hertz CJ, Krutzik SR, Hart S, Zeh K, Anderson DH, Gallo RL, Modlin RL, Kim J. PMID: 16098035; PMCID: PMC4407689.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    153. Immunology. Now presenting: gammadelta T cells. Science. 2005 Jul 08; 309(5732):252-3. Modlin RL, Sieling PA. PMID: 16002604.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    154. The role of toll-like receptors in the pathogenesis and treatment of dermatological disease. J Invest Dermatol. 2005 Jul; 125(1):1-8. McInturff JE, Modlin RL, Kim J. PMID: 15982296.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    155. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005 May 15; 174(10):6137-43. Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. PMID: 15879109.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    156. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005 Jun; 11(6):653-60. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL. PMID: 15880118; PMCID: PMC1409736.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    157. The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens. J Immunol. 2005 Mar 01; 174(5):2637-44. Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, Modlin RL. PMID: 15728470.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    158. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol. 2005 Mar 01; 174(5):2467-70. Liu PT, Krutzik SR, Kim J, Modlin RL. PMID: 15728448.
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    159. Breaking tolerance--another piece added to the vitiligo puzzle. J Invest Dermatol. 2005 Jan; 124(1):xiii-xv. Lee DJ, Modlin RL. PMID: 15654945.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    160. From plankton to pathogen recognition. Nat Med. 2004 Nov; 10(11):1173-4. Modlin RL, Cheng G. PMID: 15516915.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    161. Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis. J Biol Chem. 2004 Sep 24; 279(39):41227-39. Torrelles JB, Khoo KH, Sieling PA, Modlin RL, Zhang N, Marques AM, Treumann A, Rithner CD, Brennan PJ, Chatterjee D. PMID: 15263002.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    162. Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest. 2004 Mar; 113(5):701-8. Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL. PMID: 14991068; PMCID: PMC351318.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    163. The role of Toll-like receptors in combating mycobacteria. Semin Immunol. 2004 Feb; 16(1):35-41. Krutzik SR, Modlin RL. PMID: 14751762.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    164. Saposin C is required for lipid presentation by human CD1b. Nat Immunol. 2004 Feb; 5(2):169-74. Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE. PMID: 14716313.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    165. Toll-like receptors induce a phagocytic gene program through p38. J Exp Med. 2004 Jan 05; 199(1):81-90. Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G. PMID: 14699082; PMCID: PMC1887723.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansAnimalsCells
    166. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol. 2003 Dec 15; 171(12):6820-6. Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL. PMID: 14662888.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    167. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    168. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med. 2003 Aug; 9(8):1039-46. Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, Modlin RL, Brinkmann V, Kaufmann SH. PMID: 12872166.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansAnimalsCells
    169. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol. 2003 Jul 01; 23(7):1197-203. Walton KA, Cole AL, Yeh M, Subbanagounder G, Krutzik SR, Modlin RL, Lucas RM, Nakai J, Smart EJ, Vora DK, Berliner JA. PMID: 12775576.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    170. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J Biol Chem. 2003 Jun 13; 278(24):21327-30. Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K. PMID: 12716907.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    171. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003 May; 9(5):525-32. Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL. PMID: 12692544.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
    172. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol. 2003 Apr 01; 170(7):3812-8. Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, Modlin RL. PMID: 12646648.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansCells
    173. Human NKT cells express granulysin and exhibit antimycobacterial activity. J Immunol. 2003 Mar 15; 170(6):3154-61. Gansert JL, Kiessler V, Engele M, Wittke F, Röllinghoff M, Krensky AM, Porcelli SA, Modlin RL, Stenger S. PMID: 12626573.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    174. Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect Immun. 2003 Mar; 71(3):1427-33. Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL. PMID: 12595460; PMCID: PMC148832.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    175. Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol. 2003 Jan 10; 325(2):355-65. Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. PMID: 12488100.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    176. Toll-like receptor 2 ligands as adjuvants for human Th1 responses. J Immunol. 2003 Jan 01; 170(1):194-200. Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL. PMID: 12496400.
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    177. Role of toll-like receptors in response to bacterial infection. Contrib Microbiol. 2003; 10:149-63. Hertz CJ, Modlin RL. PMID: 12530325.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    178. Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue. Immunology. 2003 Jan; 108(1):10-5. Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA. PMID: 12519297; PMCID: PMC1782859.
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    179. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 2002 Sep; 17(3):251-63. Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G. PMID: 12354379.
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    180. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002 Aug 01; 169(3):1535-41. Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. PMID: 12133981; PMCID: PMC4636337.
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    181. The CD1b structure: antigen presentation adapts to a high-fat diet. Nat Immunol. 2002 Aug; 3(8):703-4. Niazi KR, Porcelli SA, Modlin RL. PMID: 12145652.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    182. Control of Mycobacterium tuberculosis through mammalian Toll-like receptors. Curr Opin Immunol. 2002 Aug; 14(4):452-7. Stenger S, Modlin RL. PMID: 12088679.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    183. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002 Jul 01; 169(1):10-4. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S. PMID: 12077222.
      View in: PubMed   Mentions: 416     Fields:    Translation:HumansAnimalsCells
    184. Mammalian toll-like receptors. Ann Allergy Asthma Immunol. 2002 Jun; 88(6):543-7; quiz 548-50, 583. Modlin RL. PMID: 12086359.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    185. Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders. Curr Opin Microbiol. 2002 Feb; 5(1):70-5. Sieling PA, Modlin RL. PMID: 11834372.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    186. Learning from leprosy: insights into contemporary immunology from an ancient disease. Skin Pharmacol Appl Skin Physiol. 2002 Jan-Feb; 15(1):1-6. Modlin RL. PMID: 11803252.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    187. Immunology. Chip shots--will functional genomics get functional? Science. 2001 Oct 26; 294(5543):799-801. Modlin RL, Bloom BR. PMID: 11679655.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
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