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Robert L Modlin

Title(s)Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 52-121
Los Angeles CA 90024
Phone56214, 56910
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    Other Positions
    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    IL-26 in host defense against infection by intracellular bacteria in skin
    NIH/NIAMS R01AR073252Jul 12, 2019 - Apr 30, 2024
    Role: Principal Investigator
    The skin microbiome in acne
    NIH/NIAMS R01AR074302Aug 13, 2018 - May 31, 2023
    Role: Principal Investigator
    Dermatology Scientist Training Program
    NIH/NIAMS T32AR071307Jul 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Modeling granuloma formation using engineered microcapsules
    NIH/NIAID R21AI121779Apr 15, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Immunobiology of Leprosy
    NIH/NIAMS P50AR063020Aug 16, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Deriving P. acnes Bacteriophages from Skin for Acne Therapy
    NIH/NIAMS R21AR060382Apr 1, 2011 - Mar 31, 2013
    Role: Principal Investigator
    Danaher (Leica) TCS SP5 Confocal System
    NIH/NCRR S10RR027083May 13, 2010 - May 12, 2011
    Role: Principal Investigator
    Dermatology Scientist Training Program
    NIH/NIAMS T32AR058921May 1, 2010 - Apr 30, 2015
    Role: Principal Investigator
    Application of Novel Antigens and Integrated Microfluidics for Leprosy Diagnosis
    NIH/NIAID R01AI082575Sep 28, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Role of Vitamin D Prohormone 25-OHD in the Immune Response to Tuberculosis
    NIH/NHLBI R01HL119068Jun 1, 2008 - Jun 30, 2018
    Role: Principal Investigator
    Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to Tuberculosis
    NIH/NIAID R01AI073539Jun 1, 2008 - May 31, 2014
    Role: Principal Investigator
    GRANULYSIN: ANTIMICROBIAL/ANTI-INFLAMMATORY ROLE IN ACNE
    NIH/NIAID R01AI059091Jul 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    CD1-targeted Vaccination against Tuberculosis
    NIH/NIAID U01AI056489Aug 1, 2003 - Jan 31, 2008
    Role: Principal Investigator
    Divergence of Phagocytic and Antimicrobial Programs in Leprosy
    NIH/NIAID R01AI047868Sep 1, 2000 - Jun 30, 2015
    Role: Principal Investigator
    ROLE OF TOLL-LIKE RECEPTORS IN SKIN
    NIH/NIAID R37AI047868Sep 1, 2000 - May 31, 2005
    Role: Principal Investigator
    LOCAL T-CELL RESPONSE IN HUMAN LEISHMANIASIS
    NIH/NIAID R01AI034032Sep 30, 1996 - Aug 31, 2000
    Role: Principal Investigator
    MODULATION OF T CELL RESPONSES IN TB AND HIV INFECTION
    NIH/NIAID R01AI036069Sep 1, 1994 - May 31, 1999
    Role: Principal Investigator
    T-CELL AND CYTOKINE PATTERNS IN CUTANEOUS CARCINOMA
    NIH/NCI R01CA056860Apr 1, 1992 - Mar 31, 1995
    Role: Principal Investigator
    CD1-restricted T-cell Responses in Skin
    NIH/NIAMS R01AR040312Apr 1, 1991 - May 31, 2015
    Role: Principal Investigator
    Molecular Analysis of Host Immune Response in Leprosy
    NIH/NIAID R01AI022553Jan 1, 1991 - Nov 30, 2014
    Role: Principal Investigator
    IMMUNOREGULATORY T-LYMPHOCYTES IN LEPROSY SKIN LESIONS
    NIH/NIAID R22AI022553Apr 1, 1986 - Mar 31, 1989
    Role: Principal Investigator
    IMMUNOREGULATION IN LEPROSY GRANULOMAS
    NIH/NIAID R23AI022187Sep 1, 1985 - Jun 30, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-?. iScience. 2020 May 22; 23(5):101050. Kelly-Scumpia KM, Choi A, Shirazi R, Bersabe H, Park E, Scumpia PO, Ochoa MT, Yu J, Ma F, Pellegrini M, Modlin RL. PMID: 32339990.
      View in: PubMed   Mentions:
    2. Cellular, Molecular, and Immunological Characteristics of Langhans Multinucleated Giant Cells Programmed by IL-15. J Invest Dermatol. 2020 Sep; 140(9):1824-1836.e7. Wang H, Jiang H, Teles RMB, Chen Y, Wu A, Lu J, Chen Z, Ma F, Pellegrini M, Modlin RL. PMID: 32092350.
      View in: PubMed   Mentions:    Fields:    
    3. Response to Comment on "IL-1ß Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells". J Immunol. 2019 12 15; 203(12):3093. Modlin RL. PMID: 31818921.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Identification of a systemic interferon-? inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction. PLoS Negl Trop Dis. 2019 10; 13(10):e0007764. Teles RMB, Lu J, Tió-Coma M, Goulart IMB, Banu S, Hagge D, Bobosha K, Ottenhoff THM, Pellegrini M, Geluk A, Modlin RL. PMID: 31600201.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Correction: IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. J Immunol. 2019 Oct 01; 203(7):2020. Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW. PMID: 31471522.
      View in: PubMed   Mentions:    Fields:    
    6. The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy. PLoS Negl Trop Dis. 2019 07; 13(7):e0007589. R Andrade P, Mehta M, Lu J, M B Teles R, Montoya D, O Scumpia P, Nunes Sarno E, Ochoa MT, Ma F, Pellegrini M, Modlin RL. PMID: 31344041.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. IL-1ß Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells. J Immunol. 2019 08 15; 203(4):911-921. Weiss DI, Ma F, Merleev AA, Maverakis E, Gilliet M, Balin SJ, Bryson BD, Ochoa MT, Pellegrini M, Bloom BR, Modlin RL. PMID: 31235553.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis. mSphere. 2019 06 05; 4(3). Kim EW, De Leon A, Jiang Z, Radu RA, Martineau AR, Chan ED, Bai X, Su WL, Montoya DJ, Modlin RL, Liu PT. PMID: 31167948.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Autophagy links antimicrobial activity with antigen presentation in Langerhans cells. JCI Insight. 2019 04 18; 4(8). Dang AT, Teles RM, Liu PT, Choi A, Legaspi A, Sarno EN, Ochoa MT, Parvatiyar K, Cheng G, Gilliet M, Bloom BR, Modlin RL. PMID: 30996142.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. IL-26 contributes to host defense against intracellular bacteria. J Clin Invest. 2019 04 02; 129(5):1926-1939. Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL. PMID: 30939123.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions. Sci Rep. 2019 03 27; 9(1):5288. Cheng Q, Behzadi F, Sen S, Ohta S, Spreafico R, Teles R, Modlin RL, Hoffmann A. PMID: 30918279.
      View in: PubMed   Mentions: 3     Fields:    
    12. Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response. Cell Rep. 2019 03 26; 26(13):3574-3585.e3. Montoya DJ, Andrade P, Silva BJA, Teles RMB, Ma F, Bryson B, Sadanand S, Noel T, Lu J, Sarno E, Arnvig KB, Young D, Lahiri R, Williams DL, Fortune S, Bloom BR, Pellegrini M, Modlin RL. PMID: 30917313.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Plasticity of antimicrobial and phagocytic programs in human macrophages. Immunology. 2019 02; 156(2):164-173. Montoya D, Mehta M, Ferguson BG, Teles RMB, Krutzik SR, Cruz D, Pellegrini M, Modlin RL. PMID: 30357820.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. A phylogenomic study quantifies competing mechanisms for pseudogenization in prokaryotes-The Mycobacterium leprae case. PLoS One. 2018; 13(11):e0204322. Avni E, Montoya D, Lopez D, Modlin R, Pellegrini M, Snir S. PMID: 30383852.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN. PLoS Negl Trop Dis. 2018 10; 12(10):e0006815. Zavala K, Gottlieb CA, Teles RM, Adams JS, Hewison M, Modlin RL, Liu PT. PMID: 30300363.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria. Sci Immunol. 2018 08 31; 3(26). Balin SJ, Pellegrini M, Klechevsky E, Won ST, Weiss DI, Choi AW, Hakimian J, Lu J, Ochoa MT, Bloom BR, Lanier LL, Stenger S, Modlin RL. PMID: 30171080.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae. PLoS Negl Trop Dis. 2018 07; 12(7):e0006608. Kim EW, Teles RMB, Haile S, Liu PT, Modlin RL. PMID: 29965969.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network. J Immunol. 2018 05 01; 200(9):3244-3258. Keegan C, Krutzik S, Schenk M, Scumpia PO, Lu J, Pang YLJ, Russell BS, Lim KS, Shell S, Prestwich E, Su D, Elashoff D, Hershberg RM, Bloom BR, Belisle JT, Fortune S, Dedon PC, Pellegrini M, Modlin RL. PMID: 29610140.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages. BMC Microbiol. 2018 03 01; 18(1):19. Cheng L, Marinelli LJ, Grosset N, Fitz-Gibbon ST, Bowman CA, Dang BQ, Russell DA, Jacobs-Sera D, Shi B, Pellegrini M, Miller JF, Gautier M, Hatfull GF, Modlin RL. PMID: 29490612.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    20. IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. J Immunol. 2018 04 01; 200(7):2405-2417. Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW. PMID: 29453279.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles. BMC Genomics. 2017 Oct 25; 18(1):824. Lopez D, Montoya D, Ambrose M, Lam L, Briscoe L, Adams C, Modlin RL, Pellegrini M. PMID: 29070035.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 2017 Aug 24; 170(5):973-985.e10. Madigan CA, Cambier CJ, Kelly-Scumpia KM, Scumpia PO, Cheng TY, Zailaa J, Bloom BR, Moody DB, Smale ST, Sagasti A, Modlin RL, Ramakrishnan L. PMID: 28841420.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    23. Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS Pathog. 2017 Jul; 13(7):e1006496. Scumpia PO, Botten GA, Norman JS, Kelly-Scumpia KM, Spreafico R, Ruccia AR, Purbey PK, Thomas BJ, Modlin RL, Smale ST. PMID: 28704551.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host Microbe. 2017 Mar 08; 21(3):334-343. Wang L, Liu SY, Chen HW, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX, Cheng G. PMID: 28279345.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight. 2016 09 22; 1(15):e88843. Inkeles MS, Teles RM, Pouldar D, Andrade PR, Madigan CA, Lopez D, Ambrose M, Noursadeghi M, Sarno EN, Rea TH, Ochoa MT, Iruela-Arispe ML, Swindell WR, Ottenhoff TH, Geluk A, Bloom BR, Pellegrini M, Modlin RL. PMID: 27699251.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae. Infect Immun. 2016 09; 84(9):2429-38. Schenk M, Mahapatra S, Le P, Kim HJ, Choi AW, Brennan PJ, Belisle JT, Modlin RL. PMID: 27297389.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. Jagged1 Instructs Macrophage Differentiation in Leprosy. PLoS Pathog. 2016 08; 12(8):e1005808. Kibbie J, Teles RM, Wang Z, Hong P, Montoya D, Krutzik S, Lee S, Kwon O, Modlin RL, Cruz D. PMID: 27532668.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis. Am J Respir Crit Care Med. 2016 08 01; 194(3):345-55. Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S. PMID: 26882070.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nat Commun. 2016 08 01; 7:12348. Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A. PMID: 27476449.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes. J Invest Dermatol. 2016 11; 136(11):2221-2228. Yu Y, Champer J, Agak GW, Kao S, Modlin RL, Kim J. PMID: 27377696.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    31. S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages. PLoS Pathog. 2016 06; 12(6):e1005705. Realegeno S, Kelly-Scumpia KM, Dang AT, Lu J, Teles R, Liu PT, Schenk M, Lee EY, Schmidt NW, Wong GC, Sarno EN, Rea TH, Ochoa MT, Pellegrini M, Modlin RL. PMID: 27355424.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    32. Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages. Microbiol Spectr. 2016 06; 4(3). Bloom BR, Modlin RL. PMID: 27337485.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    33. Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages. J Immunol. 2016 07 01; 197(1):222-32. Steiger J, Stephan A, Inkeles MS, Realegeno S, Bruns H, Kröll P, de Castro Kroner J, Sommer A, Batinica M, Pitzler L, Kalscheuer R, Hartmann P, Plum G, Stenger S, Pellegrini M, Brachvogel B, Modlin RL, Fabri M. PMID: 27233968.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nat Immunol. 2015 Sep; 16(9):970-9. Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M. PMID: 26168081.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    35. IL-27 Suppresses Antimicrobial Activity in Human Leprosy. J Invest Dermatol. 2015 Oct; 135(10):2410-2417. Teles RMB, Kelly-Scumpia KM, Sarno EN, Rea TH, Ochoa MT, Cheng G, Modlin RL. PMID: 26030183.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. Combinatorial code governing cellular responses to complex stimuli. Nat Commun. 2015 Apr 21; 6:6847. Cappuccio A, Zollinger R, Schenk M, Walczak A, Servant N, Barillot E, Hupé P, Modlin RL, Soumelis V. PMID: 25896517.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. Bee venom processes human skin lipids for presentation by CD1a. J Exp Med. 2015 Feb 09; 212(2):149-63. Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G. PMID: 25584012.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    38. IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci Transl Med. 2014 Aug 20; 6(250):250ra114. Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL. PMID: 25143364.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    39. Comparison of molecular signatures from multiple skin diseases identifies mechanisms of immunopathogenesis. J Invest Dermatol. 2015 Jan; 135(1):151-159. Inkeles MS, Scumpia PO, Swindell WR, Lopez D, Teles RMB, Graeber TG, Meller S, Homey B, Elder JT, Gilliet M, Modlin RL, Pellegrini M. PMID: 25111617.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014; 5:151. Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. PMID: 24795646.
      View in: PubMed   Mentions:
    41. Interleukin-1ß triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology. 2014 Feb; 141(2):174-80. Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, Montoya D, Liu PT, Modlin RL. PMID: 24032597.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    42. TB or not TB: that is no longer the question. Sci Transl Med. 2013 Nov 27; 5(213):213sr6. Modlin RL, Bloom BR. PMID: 24285487.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    43. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science. 2013 Mar 22; 339(6126):1448-53. Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL. PMID: 23449998.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    44. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013 Sep; 133(9):2152-60. Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, Modlin RL, Miller JF, Sodergren E, Craft N, Weinstock GM, Li H. PMID: 23337890.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    45. Galectin-3 regulates the innate immune response of human monocytes. J Infect Dis. 2013 Mar 15; 207(6):947-56. Chung AW, Sieling PA, Schenk M, Teles RM, Krutzik SR, Hsu DK, Liu FT, Sarno EN, Rea TH, Stenger S, Modlin RL, Lee DJ. PMID: 23255567.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    46. Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens. J Invest Dermatol. 2013 May; 133(5):1231-9. Friedman AJ, Phan J, Schairer DO, Champer J, Qin M, Pirouz A, Blecher-Paz K, Oren A, Liu PT, Modlin RL, Kim J. PMID: 23190896.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    47. The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol. 2012 Dec; 13(12):1155-61. Parvatiyar K, Zhang Z, Teles RM, Ouyang S, Jiang Y, Iyer SS, Zaver SA, Schenk M, Zeng S, Zhong W, Liu ZJ, Modlin RL, Liu YJ, Cheng G. PMID: 23142775.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    48. Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. mBio. 2012; 3(5). Marinelli LJ, Fitz-Gibbon S, Hayes C, Bowman C, Inkeles M, Loncaric A, Russell DA, Jacobs-Sera D, Cokus S, Pellegrini M, Kim J, Miller JF, Hatfull GF, Modlin RL. PMID: 23015740.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    49. Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages. J Immunol. 2012 Oct 15; 189(8):4069-78. Bruns H, Stegelmann F, Fabri M, Döhner K, van Zandbergen G, Wagner M, Skinner M, Modlin RL, Stenger S. PMID: 22988030.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    50. Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells. Glycobiology. 2012 Aug; 22(8):1118-27. Torrelles JB, Sieling PA, Zhang N, Keen MA, McNeil MR, Belisle JT, Modlin RL, Brennan PJ, Chatterjee D. PMID: 22534567.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    51. NOD2 triggers an interleukin-32-dependent human dendritic cell program in leprosy. Nat Med. 2012 Mar 25; 18(4):555-63. Schenk M, Krutzik SR, Sieling PA, Lee DJ, Teles RM, Ochoa MT, Komisopoulou E, Sarno EN, Rea TH, Graeber TG, Kim S, Cheng G, Modlin RL. PMID: 22447076.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    52. A review of the Journal of Investigative Dermatology's most cited publications over the past 25 years and the use of developing bibliometric methodologies to assess journal quality. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):1050-60. Bickers DR, Modlin RL. PMID: 22330274.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    53. Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells. Blood. 2012 Mar 29; 119(13):3128-31. Hou W, Gibbs JS, Lu X, Brooke CB, Roy D, Modlin RL, Bennink JR, Yewdell JW. PMID: 22310910.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    54. MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy. Nat Med. 2012 Jan 29; 18(2):267-73. Liu PT, Wheelwright M, Teles R, Komisopoulou E, Edfeldt K, Ferguson B, Mehta MD, Vazirnia A, Rea TH, Sarno EN, Graeber TG, Modlin RL. PMID: 22286305.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    55. Innate immunity: ignored for decades, but not forgotten. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):882-6. Modlin RL. PMID: 22158552.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    56. Shedding light on the vitamin D-tuberculosis-HIV connection. Proc Natl Acad Sci U S A. 2011 Nov 22; 108(47):18861-2. Realegeno S, Modlin RL. PMID: 22084116.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    57. Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12; 3(104):104ra102. Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. PMID: 21998409.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    58. Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses. J Biol Chem. 2011 Oct 14; 286(41):35438-46. Torrelles JB, Sieling PA, Arcos J, Knaup R, Bartling C, Rajaram MV, Stenger S, Modlin RL, Schlesinger LS. PMID: 21859718.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    59. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab. 2011 Jun; 96(6):1835-43. Walker VP, Zhang X, Rastegar I, Liu PT, Hollis BW, Adams JS, Modlin RL. PMID: 21470993.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    60. Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6769-74. Cruz D, Wang Z, Kibbie J, Modlin R, Kwon O. PMID: 21383121.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    61. Noninvasive in vivo imaging to evaluate immune responses and antimicrobial therapy against Staphylococcus aureus and USA300 MRSA skin infections. J Invest Dermatol. 2011 Apr; 131(4):907-15. Cho JS, Zussman J, Donegan NP, Ramos RI, Garcia NC, Uslan DZ, Iwakura Y, Simon SI, Cheung AL, Modlin RL, Kim J, Miller LS. PMID: 21191403.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    62. Editorial overview. Curr Opin Immunol. 2011 Feb; 23(1):1-2. Glimcher LH, Martinon F, Modlin RL. PMID: 21185707.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    63. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22593-8. Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL. PMID: 21149724.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    64. Role of autophagy in the host response to microbial infection and potential for therapy. Curr Opin Immunol. 2011 Feb; 23(1):65-70. Fabri M, Realegeno SE, Jo EK, Modlin RL. PMID: 21071195.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    65. A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy. Immunology. 2010 Nov; 131(3):405-14. Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ. PMID: 20561085.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    66. Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium leprae by Schwann cells in human leprosy. Infect Immun. 2010 Nov; 78(11):4634-43. Teles RM, Krutzik SR, Ochoa MT, Oliveira RB, Sarno EN, Modlin RL. PMID: 20713631.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    67. Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab. 2010 Jul; 95(7):3368-76. Chun RF, Lauridsen AL, Suon L, Zella LA, Pike JW, Modlin RL, Martineau AR, Wilkinson RJ, Adams J, Hewison M. PMID: 20427486.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    68. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest. 2010 May; 120(5):1762-73. Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS. PMID: 20364087.
      View in: PubMed   Mentions: 216     Fields:    Translation:AnimalsCells
    69. Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis. 2010 Feb 15; 201(4):558-69. Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL. PMID: 20070238.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    70. The innate immune response in leprosy. Curr Opin Immunol. 2010 Feb; 22(1):48-54. Modlin RL. PMID: 20060279.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    71. Learning from leprosy: insight into the human innate immune response. Adv Immunol. 2010; 105:1-24. Montoya D, Modlin RL. PMID: 20510728.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    72. TLR2 looks at lipoproteins. Immunity. 2009 Dec 18; 31(6):847-9. Schenk M, Belisle JT, Modlin RL. PMID: 20064441.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    73. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009 Oct 22; 6(4):343-53. Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. PMID: 19837374.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    74. A vitamin for autophagy. Cell Host Microbe. 2009 Sep 17; 6(3):201-3. Fabri M, Modlin RL. PMID: 19748462.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    75. T cell responses in microbial infection. Curr Opin Immunol. 2009 Aug; 21(4):365-6. Modlin RL, Brenner MB. PMID: 19643590.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    76. Activation of Fc gamma RI on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses. J Immunol. 2009 Aug 15; 183(4):2349-55. Tanaka M, Krutzik SR, Sieling PA, Lee DJ, Rea TH, Modlin RL. PMID: 19635920.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    77. Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K. J Immunol. 2009 Jul 01; 183(1):491-8. Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT. PMID: 19542460.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    78. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One. 2009 Jun 05; 4(6):e5810. Liu PT, Schenk M, Walker VP, Dempsey PW, Kanchanapoomi M, Wheelwright M, Vazirnia A, Zhang X, Steinmeyer A, Zügel U, Hollis BW, Cheng G, Modlin RL. PMID: 19503839.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    79. The vitamin D connection to pediatric infections and immune function. Pediatr Res. 2009 May; 65(5 Pt 2):106R-113R. Walker VP, Modlin RL. PMID: 19190532.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    80. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009 Apr 01; 182(7):4289-95. Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. PMID: 19299728.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    81. DNA transportation authority. Nat Med. 2008 Dec; 14(12):1319-20. Lee DJ, Modlin RL. PMID: 19057557.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    82. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol. 2008 Nov 15; 181(10):7115-20. Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, Modlin RL. PMID: 18981132.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    83. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    84. Human macrophage host defense against Mycobacterium tuberculosis. Curr Opin Immunol. 2008 Aug; 20(4):371-6. Liu PT, Modlin RL. PMID: 18602003.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    85. Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation. J Immunol. 2008 May 01; 180(9):5833-42. Sieling PA, Hill PJ, Dobos KM, Brookman K, Kuhlman AM, Fabri M, Krutzik SR, Rea TH, Heaslip DG, Belisle JT, Modlin RL. PMID: 18424702.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    86. "Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages. J Invest Dermatol. 2008 Sep; 128(9):2225-31. Ochoa MT, Loncaric A, Krutzik SR, Becker TC, Modlin RL. PMID: 18337829.
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    87. LILRA2 activation inhibits dendritic cell differentiation and antigen presentation to T cells. J Immunol. 2007 Dec 15; 179(12):8128-36. Lee DJ, Sieling PA, Ochoa MT, Krutzik SR, Guo B, Hernandez M, Rea TH, Cheng G, Colonna M, Modlin RL. PMID: 18056355.
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    88. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V20-4. Adams JS, Chen H, Chun R, Ren S, Wu S, Gacad M, Nguyen L, Ride J, Liu P, Modlin R, Hewison M. PMID: 18290716.
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    89. Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol. 2007 Nov 15; 179(10):6933-42. Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL. PMID: 17982084.
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    90. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007 Aug 15; 179(4):2060-3. Liu PT, Stenger S, Tang DH, Modlin RL. PMID: 17675463.
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    91. Vitamin D in defense of the human immune response. Ann N Y Acad Sci. 2007 Nov; 1117:94-105. Adams JS, Liu PT, Chun R, Modlin RL, Hewison M. PMID: 17656563.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    92. Activation of human CD4+ T cells by targeting MHC class II epitopes to endosomal compartments using human CD1 tail sequences. Immunology. 2007 Dec; 122(4):522-31. Niazi KR, Ochoa MT, Sieling PA, Rooke NE, Peter AK, Mollahan P, Dickey M, Rabizadeh S, Rea TH, Modlin RL. PMID: 17635609.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    93. Toll-like receptors in the skin. Semin Immunopathol. 2007 Apr; 29(1):15-26. Miller LS, Modlin RL. PMID: 17621951.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    94. Regulation of human T-cell homing receptor expression in cutaneous bacterial infection. Immunology. 2007 Apr; 120(4):518-25. Sieling PA, Legaspi A, Ochoa MT, Rea TH, Modlin RL. PMID: 17343614.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    95. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):316-21. Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P, Modlin RL, Adams JS. PMID: 17368179.
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    96. Therapeutic implications of the TLR and VDR partnership. Trends Mol Med. 2007 Mar; 13(3):117-24. Liu PT, Krutzik SR, Modlin RL. PMID: 17276732.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    97. Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization. J Immunol. 2007 Feb 01; 178(3):1829-34. Di Nardo A, Braff MH, Taylor KR, Na C, Granstein RD, McInturff JE, Krutzik S, Modlin RL, Gallo RL. PMID: 17237433.
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    98. Human keratinocyte Toll-like receptors promote distinct immune responses. J Invest Dermatol. 2007 Feb; 127(2):262-3. Miller LS, Modlin RL. PMID: 17228303.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    99. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity. 2007 Jan; 26(1):117-29. Winau F, Hegasy G, Weiskirchen R, Weber S, Cassan C, Sieling PA, Modlin RL, Liblau RS, Gressner AM, Kaufmann SH. PMID: 17239632.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    100. Functional characterization of a T-cell receptor BV6+ T-cell clone derived from a leprosy lesion. Immunology. 2007 Mar; 120(3):354-61. Sabet S, Ochoa MT, Sieling PA, Rea TH, Modlin RL. PMID: 17140401.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    101. A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. J Exp Med. 2006 Nov 27; 203(12):2589-602. Chow EK, Castrillo A, Shahangian A, Pei L, O'Connell RM, Modlin RL, Tontonoz P, Cheng G. PMID: 17074929.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    102. Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells. J Immunol. 2006 Oct 15; 177(8):5226-35. Im JS, Tapinos N, Chae GT, Illarionov PA, Besra GS, DeVries GH, Modlin RL, Sieling PA, Rambukkana A, Porcelli SA. PMID: 17015708.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    103. Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens. J Immunol. 2006 Aug 01; 177(3):1864-71. Tan BH, Meinken C, Bastian M, Bruns H, Legaspi A, Ochoa MT, Krutzik SR, Bloom BR, Ganz T, Modlin RL, Stenger S. PMID: 16849498.
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    104. TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006 Jul 01; 177(1):298-305. Renn CN, Sanchez DJ, Ochoa MT, Legaspi AJ, Oh CK, Liu PT, Krutzik SR, Sieling PA, Cheng G, Modlin RL. PMID: 16785525.
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    105. Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation. J Immunol. 2006 Mar 15; 176(6):3536-47. Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED. PMID: 16517722.
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    106. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. PMID: 16497887.
      View in: PubMed   Mentions: 1003     Fields:    Translation:HumansCells
    107. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity. 2006 Jan; 24(1):79-91. Miller LS, O'Connell RM, Gutierrez MA, Pietras EM, Shahangian A, Gross CE, Thirumala A, Cheung AL, Cheng G, Modlin RL. PMID: 16413925.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    108. Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis. J Immunol. 2005 Dec 01; 175(11):7474-83. Stegelmann F, Bastian M, Swoboda K, Bhat R, Kiessler V, Krensky AM, Roellinghoff M, Modlin RL, Stenger S. PMID: 16301655.
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    109. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. J Invest Dermatol. 2005 Aug; 125(2):256-63. McInturff JE, Wang SJ, Machleidt T, Lin TR, Oren A, Hertz CJ, Krutzik SR, Hart S, Zeh K, Anderson DH, Gallo RL, Modlin RL, Kim J. PMID: 16098035.
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    110. Immunology. Now presenting: gammadelta T cells. Science. 2005 Jul 08; 309(5732):252-3. Modlin RL, Sieling PA. PMID: 16002604.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    111. The role of toll-like receptors in the pathogenesis and treatment of dermatological disease. J Invest Dermatol. 2005 Jul; 125(1):1-8. McInturff JE, Modlin RL, Kim J. PMID: 15982296.
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    112. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005 May 15; 174(10):6137-43. Miller LS, Sørensen OE, Liu PT, Jalian HR, Eshtiaghpour D, Behmanesh BE, Chung W, Starner TD, Kim J, Sieling PA, Ganz T, Modlin RL. PMID: 15879109.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    113. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nat Med. 2005 Jun; 11(6):653-60. Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL. PMID: 15880118.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    114. The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens. J Immunol. 2005 Mar 01; 174(5):2637-44. Sieling PA, Torrelles JB, Stenger S, Chung W, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Porcelli SA, Modlin RL. PMID: 15728470.
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    115. Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function. J Immunol. 2005 Mar 01; 174(5):2467-70. Liu PT, Krutzik SR, Kim J, Modlin RL. PMID: 15728448.
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    116. Breaking tolerance--another piece added to the vitiligo puzzle. J Invest Dermatol. 2005 Jan; 124(1):xiii-xv. Lee DJ, Modlin RL. PMID: 15654945.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    117. From plankton to pathogen recognition. Nat Med. 2004 Nov; 10(11):1173-4. Modlin RL, Cheng G. PMID: 15516915.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    118. Truncated structural variants of lipoarabinomannan in Mycobacterium leprae and an ethambutol-resistant strain of Mycobacterium tuberculosis. J Biol Chem. 2004 Sep 24; 279(39):41227-39. Torrelles JB, Khoo KH, Sieling PA, Modlin RL, Zhang N, Marques AM, Treumann A, Rithner CD, Brennan PJ, Chatterjee D. PMID: 15263002.
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    119. Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J Clin Invest. 2004 Mar; 113(5):701-8. Hunger RE, Sieling PA, Ochoa MT, Sugaya M, Burdick AE, Rea TH, Brennan PJ, Belisle JT, Blauvelt A, Porcelli SA, Modlin RL. PMID: 14991068.
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    120. The role of Toll-like receptors in combating mycobacteria. Semin Immunol. 2004 Feb; 16(1):35-41. Krutzik SR, Modlin RL. PMID: 14751762.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    121. Saposin C is required for lipid presentation by human CD1b. Nat Immunol. 2004 Feb; 5(2):169-74. Winau F, Schwierzeck V, Hurwitz R, Remmel N, Sieling PA, Modlin RL, Porcelli SA, Brinkmann V, Sugita M, Sandhoff K, Kaufmann SH, Schaible UE. PMID: 14716313.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    122. Toll-like receptors induce a phagocytic gene program through p38. J Exp Med. 2004 Jan 05; 199(1):81-90. Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G. PMID: 14699082.
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    123. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2. J Immunol. 2003 Dec 15; 171(12):6820-6. Hertz CJ, Wu Q, Porter EM, Zhang YJ, Weismüller KH, Godowski PJ, Ganz T, Randell SH, Modlin RL. PMID: 14662888.
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    124. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.
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    125. Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis. Nat Med. 2003 Aug; 9(8):1039-46. Schaible UE, Winau F, Sieling PA, Fischer K, Collins HL, Hagens K, Modlin RL, Brinkmann V, Kaufmann SH. PMID: 12872166.
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    126. Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2. Arterioscler Thromb Vasc Biol. 2003 Jul 01; 23(7):1197-203. Walton KA, Cole AL, Yeh M, Subbanagounder G, Krutzik SR, Modlin RL, Lucas RM, Nakai J, Smart EJ, Vora DK, Berliner JA. PMID: 12775576.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    127. PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4. J Biol Chem. 2003 Jun 13; 278(24):21327-30. Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K. PMID: 12716907.
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    128. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003 May; 9(5):525-32. Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL. PMID: 12692544.
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    129. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J Immunol. 2003 Apr 01; 170(7):3812-8. Bleharski JR, Kiessler V, Buonsanti C, Sieling PA, Stenger S, Colonna M, Modlin RL. PMID: 12646648.
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    130. Human NKT cells express granulysin and exhibit antimycobacterial activity. J Immunol. 2003 Mar 15; 170(6):3154-61. Gansert JL, Kiessler V, Engele M, Wittke F, Röllinghoff M, Krensky AM, Porcelli SA, Modlin RL, Stenger S. PMID: 12626573.
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    131. Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy. Infect Immun. 2003 Mar; 71(3):1427-33. Oliveira RB, Ochoa MT, Sieling PA, Rea TH, Rambukkana A, Sarno EN, Modlin RL. PMID: 12595460.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    132. Toll-like receptor 2 ligands as adjuvants for human Th1 responses. J Immunol. 2003 Jan 01; 170(1):194-200. Sieling PA, Chung W, Duong BT, Godowski PJ, Modlin RL. PMID: 12496400.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    133. Role of toll-like receptors in response to bacterial infection. Contrib Microbiol. 2003; 10:149-63. Hertz CJ, Modlin RL. PMID: 12530325.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    134. Distribution of Toll-like receptor 1 and Toll-like receptor 2 in human lymphoid tissue. Immunology. 2003 Jan; 108(1):10-5. Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin RL, Sieling PA. PMID: 12519297.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    135. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 2002 Sep; 17(3):251-63. Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G. PMID: 12354379.
      View in: PubMed   Mentions: 272     Fields:    Translation:HumansAnimalsCells
    136. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol. 2002 Aug 01; 169(3):1535-41. Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. PMID: 12133981.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    137. The CD1b structure: antigen presentation adapts to a high-fat diet. Nat Immunol. 2002 Aug; 3(8):703-4. Niazi KR, Porcelli SA, Modlin RL. PMID: 12145652.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    138. Control of Mycobacterium tuberculosis through mammalian Toll-like receptors. Curr Opin Immunol. 2002 Aug; 14(4):452-7. Stenger S, Modlin RL. PMID: 12088679.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    139. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002 Jul 01; 169(1):10-4. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL, Akira S. PMID: 12077222.
      View in: PubMed   Mentions: 330     Fields:    Translation:HumansAnimalsCells
    140. Mammalian toll-like receptors. Ann Allergy Asthma Immunol. 2002 Jun; 88(6):543-7; quiz 548-50, 583. Modlin RL. PMID: 12086359.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    141. Toll-like receptors: mammalian "taste receptors" for a smorgasbord of microbial invaders. Curr Opin Microbiol. 2002 Feb; 5(1):70-5. Sieling PA, Modlin RL. PMID: 11834372.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    142. Learning from leprosy: insights into contemporary immunology from an ancient disease. Skin Pharmacol Appl Skin Physiol. 2002 Jan-Feb; 15(1):1-6. Modlin RL. PMID: 11803252.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    143. Immunology. Chip shots--will functional genomics get functional? Science. 2001 Oct 26; 294(5543):799-801. Modlin RL, Bloom BR. PMID: 11679655.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
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