Otto Orlean Yang

Title(s)Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0003-1970-8992 Additional info
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    Other Positions
    Title(s)Professor, MIMG


    Collapse Biography 
    Collapse Education and Training
    Brown University, Providence, RIScB06/1987Human Biology
    Brown University Medical School, Providence, RIMD06/1990Medicine
    New York University-Bellevue Hospital, New York, NYResidency06/1993Internal Medicine
    Harvard University Medical School-Massachusetts General Hospital, Boston, MAFellowship06/1997Infectious Diseases
    Harvard University, Boston, MAPost-Doc06/1997Immunology and Virology

    Collapse Research 
    Collapse Research Activities and Funding
    Dual CMV and HIV CARs for Cure of HIV
    NIH R21AI136606Mar 5, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
    NIH R01AI140775Jan 16, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Los Angeles CRS for the MACS/WIHS Combined Cohort Study
    NIH U01HL146333Apr 1, 2019 - Mar 31, 2026
    Role: Co-Principal Investigator
    Chimeric Broadly Neutralizing Anti-HIV Antibodies
    NIH R21AI131879May 11, 2018 - Apr 30, 2020
    Role: Principal Investigator
    CD4 T Cell Differentiation and Susceptibility to HIV-Specific CTL Killing
    NIH R21AI122939Aug 16, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Dissection of HIV-1 CTL Escape Pathways
    NIH R01DE025166Sep 13, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Topical Microbicides: Targeted Intracellular Delivery
    NIH R01AI112016Mar 1, 2014 - Feb 28, 2018
    Role: Principal Investigator
    Functional Assessment of CTL Anergy in HIV Infection
    NIH R21AI110343Feb 1, 2014 - Jul 31, 2016
    Role: Principal Investigator
    Bio-Nanoparticles for HIV Antigen Delivery
    NIH R21AI106528Apr 19, 2013 - Mar 31, 2015
    Role: Principal Investigator
    Mechanistic Studies of HIV-exposed Seronegative Individuals
    NIH R56AI100638Aug 1, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Identifying and closing gaps in TCR coverage of HIV-1 escape
    NIH R56AI093138Aug 1, 2011 - Jul 31, 2013
    Role: Principal Investigator
    TRANSLATIONAL AIDS AND VIRAL PATHOGENESIS TRAINING
    NIH T32AI089398May 15, 2010 - Jul 31, 2020
    Role: Principal Investigator
    Addressing Intra-/Inter-Clade Diversity in HIV Vaccine Design by Immune Focusing
    NIH R21AI087382Apr 12, 2010 - Mar 31, 2013
    Role: Principal Investigator
    Mucosal and Peripheral NK-T Cells in HIV Infection
    NIH R21AI063974Apr 1, 2006 - Mar 31, 2008
    Role: Principal Investigator
    Immune Pressure on HIV-1 Nef by Cytotoxic T Lymphocytes
    NIH R01AI051970Apr 1, 2002 - Jun 30, 2013
    Role: Principal Investigator
    HIV-1 Escape from Inhibition by Cytotoxic T Lymphocytes
    NIH R01AI043203Apr 1, 1998 - Mar 31, 2013
    Role: Principal Investigator
    INHIBITION OF HIV 1 BY CYTOTOXIC T LYMPHOCYTES
    NIH K08AI001413Aug 1, 1996 - Jul 31, 1999
    Role: Principal Investigator
    INHIBITION OF HIV-1 BY CYTOTOXIC T LYMPHOCYTES
    NIH F32AI009270Oct 31, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NK Cell-Monocyte Cross-talk Underlies NK Cell Activation in Severe COVID-19. J Immunol. 2024 Apr 05. Lee MJ, de Los Rios Kobara I, Barnard TR, Vales Torres X, Tobin NH, Ferbas KG, Rimoin AW, Yang OO, Aldrovandi GM, Wilk AJ, Fulcher JA, Blish CA. PMID: 38578283.
      View in: PubMed   Mentions:    Fields:    
    2. Understanding immune dysregulation in post-acute sequelae of COVID-19 (PASC) - The hunt for effective treatments. J Infect. 2024 Mar 24; 106146. Gaylis NB, Yang OO. PMID: 38531430.
      View in: PubMed   Mentions:    Fields:    
    3. A Risk Profile Using Simple Hematologic Parameters to Assess Benefits From Baricitinib in Patients Hospitalized With COVID-19: A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-2. Ann Intern Med. 2024 Feb 27. Paules CI, Wang J, Tomashek KM, Bonnett T, Singh K, Marconi VC, Davey RT, Lye DC, Dodd LE, Yang OO, Benson CA, Deye GA, Doernberg SB, Hynes NA, Grossberg R, Wolfe CR, Nayak SU, Short WR, Voell J, Potter GE, Rapaka RR. PMID: 38408357.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Direct Detection of 4-Dimensions of SARS-CoV-2: Infection (vRNA), Infectivity (Antigen), Binding Antibody, and Functional Neutralizing Antibody in Saliva. Res Sq. 2023 Dec 28. Mohammadi A, Chiang S, Li F, Wei F, Lau CS, Aziz M, Ibarrondo FJ, Fulcher JA, Yang OO, Chia D, Kim Y, Wong DTW. PMID: 38234820; PMCID: PMC10793499.
      View in: PubMed   Mentions:
    5. IFN-γ-mediated control of SARS-CoV-2 infection through nitric oxide. Front Immunol. 2023; 14:1284148. Silva BJA, Krogstad PA, Teles RMB, Andrade PR, Rajfer J, Ferrini MG, Yang OO, Bloom BR, Modlin RL. PMID: 38162653; PMCID: PMC10755032.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus. Virus Evol. 2023; 9(2):vead058. Li X, Habibipour S, Chou T, Yang OO. PMID: 37841642; PMCID: PMC10569380.
      View in: PubMed   Mentions:
    7. The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus. ArXiv. 2023 Aug 07. Li X, Habibipour S, Chou T, Yang OO. PMID: 37608930; PMCID: PMC10441442.
      View in: PubMed   Mentions:
    8. Vascular and Non-HLA autoantibody profiles in hospitalized patients with COVID-19. Front Immunol. 2023; 14:1197326. Lichtenstein B, Zheng Y, Gjertson D, Ferbas KG, Rimoin AW, Yang OO, Aldrovandi GM, Schaenman JM, Reed EF, Fulcher JA. PMID: 37398658; PMCID: PMC10309004.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Predominantly defective CD8+ T cell immunity to SARS-CoV-2 mRNA vaccination in lung transplant recipients. J Transl Med. 2023 06 08; 21(1):374. Taus E, Shino MY, Ibarrondo FJ, Hausner MA, Hofmann C, Yang OO. PMID: 37291575; PMCID: PMC10248978.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    10. Persistent memory despite rapid contraction of circulating T Cell responses to SARS-CoV-2 mRNA vaccination. Front Immunol. 2023; 14:1100594. Taus E, Hofmann C, Ibarrondo FJ, Gong LS, Hausner MA, Fulcher JA, Krogstad P, Kitchen SG, Ferbas KG, Tobin NH, Rimoin AW, Aldrovandi GM, Yang OO. PMID: 36860850; PMCID: PMC9968837.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    11. Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. J Infect Dis. 2023 01 11; 227(2):236-245. Cambou MC, Liu CM, Mok T, Fajardo-Martinez V, Paiola SG, Ibarrondo FJ, Kerin T, Fuller T, Tobin NH, Garcia G, Bhattacharya D, Aldrovandi GM, Arumugaswami V, Foo SS, Jung JU, Vasconcelos Z, Brasil P, Brendolin M, Yang OO, Rao R, Nielsen-Saines K. PMID: 36082433; PMCID: PMC9494415.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Autophagy inducer rapamycin treatment reduces IFN-I-mediated Inflammation and improves anti-HIV-1 T cell response in vivo. JCI Insight. 2022 11 22; 7(22). Mu W, Rezek V, Martin H, Carrillo MA, Tomer S, Hamid P, Lizarraga MA, Tibbe TD, Yang OO, Jamieson BD, Kitchen SG, Zhen A. PMID: 36509289; PMCID: PMC9746825.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Reply to Viel. Clin Infect Dis. 2022 10 12; 75(8):1486-1487. Recknor C, Hansen SG, Gaylis NB, Tiwary M, Sacha JB, Yang OO. PMID: 35819204.
      View in: PubMed   Mentions:    Fields:    
    14. Early SARS-CoV-2 dynamics and immune responses in unvaccinated participants of an intensely sampled longitudinal surveillance study. Commun Med (Lond). 2022; 2:129. Gunawardana M, Webster S, Rivera S, Cortez JM, Breslin J, Pinales C, Buser C, Ibarrondo FJ, Yang OO, Bobardt M, Gallay PA, Adler AP, Ramirez CM, Anton PA, Baum MM. PMID: 36238348; PMCID: PMC9553075.
      View in: PubMed   Mentions:
    15. Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome. Clin Infect Dis. 2022 Sep 30; 75(7):1232-1234. Gaylis NB, Ritter A, Kelly SA, Pourhassan NZ, Tiwary M, Sacha JB, Hansen SG, Recknor C, Yang OO. PMID: 35452519; PMCID: PMC9383814.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    16. Machine learning prediction of COVID-19 severity levels from salivaomics data. ArXiv. 2022 Jul 15. Wang A, Li F, Chiang S, Fulcher J, Yang O, Wong D, Wei F. PMID: 35859658; PMCID: PMC9298132.
      View in: PubMed   Mentions:
    17. Baricitinib versus dexamethasone for adults hospitalised with COVID-19 (ACTT-4): a randomised, double-blind, double placebo-controlled trial. Lancet Respir Med. 2022 09; 10(9):888-899. Wolfe CR, Tomashek KM, Patterson TF, Gomez CA, Marconi VC, Jain MK, Yang OO, Paules CI, Palacios GMR, Grossberg R, Harkins MS, Mularski RA, Erdmann N, Sandkovsky U, Almasri E, Pineda JR, Dretler AW, de Castilla DL, Branche AR, Park PK, Mehta AK, Short WR, McLellan SLF, Kline S, Iovine NM, El Sahly HM, Doernberg SB, Oh MD, Huprikar N, Hohmann E, Kelley CF, Holodniy M, Kim ES, Sweeney DA, Finberg RW, Grimes KA, Maves RC, Ko ER, Engemann JJ, Taylor BS, Ponce PO, Larson L, Melendez DP, Seibert AM, Rouphael NG, Strebe J, Clark JL, Julian KG, de Leon AP, Cardoso A, de Bono S, Atmar RL, Ganesan A, Ferreira JL, Green M, Makowski M, Bonnett T, Beresnev T, Ghazaryan V, Dempsey W, Nayak SU, Dodd LE, Beigel JH, Kalil AC, ACTT-4 Study Group. PMID: 35617986; PMCID: PMC9126560.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    18. Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More? Open Forum Infect Dis. 2022 Jul; 9(7):ofac222. Tobin NH, Yang OO. PMID: 35821728; PMCID: PMC9272428.
      View in: PubMed   Mentions:
    19. Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data. Clin Infect Dis. 2022 04 09; 74(7):1260-1264. Paules CI, Gallagher SK, Rapaka RR, Davey RT, Doernberg SB, Grossberg R, Hynes NA, Ponce PO, Short WR, Voell J, Wang J, Yang OO, Wolfe CR, Lye DC, Dodd LE, Benson CA. PMID: 34379740; PMCID: PMC8436376.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Dominant CD8+ T Cell Nucleocapsid Targeting in SARS-CoV-2 Infection and Broad Spike Targeting From Vaccination. Front Immunol. 2022; 13:835830. Taus E, Hofmann C, Ibarrondo FJ, Hausner MA, Fulcher JA, Krogstad P, Ferbas KG, Tobin NH, Rimoin AW, Aldrovandi GM, Yang OO. PMID: 35273611; PMCID: PMC8902813.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    21. Previous Infection Combined with Vaccination Produces Neutralizing Antibodies with Potency against SARS-CoV-2 Variants. mBio. 2021 12 21; 12(6):e0265621. Ibarrondo FJ, Hofmann C, Ali A, Ayoub P, Kohn DB, Yang OO. PMID: 34872349; PMCID: PMC8649753.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsPHPublic Health
    22. Clinical Characteristics and Outcomes of Coronavirus Disease 2019 Patients Who Received Compassionate-Use Leronlimab. Clin Infect Dis. 2021 12 06; 73(11):e4082-e4089. Yang B, Fulcher JA, Ahn J, Berro M, Goodman-Meza D, Dhody K, Sacha JB, Naeim A, Yang OO. PMID: 33079180; PMCID: PMC7665416.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Humoral responses to SARS-CoV-2 mRNA vaccines: Role of past infection. PLoS One. 2021; 16(11):e0259703. Gray AN, Martin-Blais R, Tobin NH, Wang Y, Brooker SL, Li F, Gadoth A, Elliott J, Faure-Kumar E, Halbrook M, Hofmann C, Kashani S, Kazan C, Yang OO, Fulcher JA, Grovit-Ferbas K, Rimoin AW, Aldrovandi GM. PMID: 34748607; PMCID: PMC8575273.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    24. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2. Cell Rep Med. 2021 11 16; 2(11):100453. Foo SS, Cambou MC, Mok T, Fajardo VM, Jung KL, Fuller T, Chen W, Kerin T, Mei J, Bhattacharya D, Choi Y, Wu X, Xia T, Shin WJ, Cranston J, Aldrovandi G, Tobin N, Contreras D, Ibarrondo FJ, Yang O, Yang S, Garner O, Cortado R, Bryson Y, Janzen C, Ghosh S, Devaskar S, Asilnejad B, Moreira ME, Vasconcelos Z, Soni PR, Gibson LC, Brasil P, Comhair SAA, Arumugaswami V, Erzurum SC, Rao R, Jung JU, Nielsen-Saines K. PMID: 34723226; PMCID: PMC8549189.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    25. Correction for Balamurugan et al., "Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones". J Virol. 2021 Oct 13; 95(21):e0139721. Balamurugan A, Ng HL, Yang OO. PMID: 34643118; PMCID: PMC8513476.
      View in: PubMed   Mentions:    Fields:    
    26. Serological Responses to Toxoplasma gondii and Matrix Antigen 1 Predict the Risk of Subsequent Toxoplasmic Encephalitis in People Living With Human Immunodeficiency Virus (HIV). Clin Infect Dis. 2021 10 05; 73(7):e2270-e2277. Xiao J, Bhondoekhan F, Seaberg EC, Yang O, Stosor V, Margolick JB, Yolken RH, Viscidi RP. PMID: 33388768; PMCID: PMC8678584.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    27. Correction: Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 Aug; 17(8):e1009895. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 34460861; PMCID: PMC8405002.
      View in: PubMed   Mentions: 1     Fields:    
    28. HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection. J Clin Invest. 2021 08 16; 131(16). Bansal A, Gehre MN, Qin K, Sterrett S, Ali A, Dang Y, Abraham S, Costanzo MC, Venegas LA, Tang J, Manjunath N, Brockman MA, Yang OO, Kan-Mitchell J, Goepfert PA. PMID: 34228645; PMCID: PMC8363272.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. Longitudinal COVID-19 Surveillance and Characterization in the Workplace with Public Health and Diagnostic Endpoints. mSphere. 2021 08 25; 6(4):e0054221. Gunawardana M, Breslin J, Cortez JM, Rivera S, Webster S, Ibarrondo FJ, Yang OO, Pyles RB, Ramirez CM, Adler AP, Anton PA, Baum MM. PMID: 34232081; PMCID: PMC8386432.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    30. Longitudinal Analysis of the T-cell Receptor Repertoire in Graft-infiltrating Lymphocytes Following Hand Transplantation. Transplantation. 2021 07 01; 105(7):1502-1509. Kim JY, Lei Z, Maienschein-Cline M, Chlipala GE, Balamurugan A, McDiarmid SV, Azari K, Yang OO. PMID: 33208695; PMCID: PMC8221714.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Primary, Recall, and Decay Kinetics of SARS-CoV-2 Vaccine Antibody Responses. ACS Nano. 2021 07 27; 15(7):11180-11191. Ibarrondo FJ, Hofmann C, Fulcher JA, Goodman-Meza D, Mu W, Hausner MA, Ali A, Balamurugan A, Taus E, Elliott J, Krogstad P, Tobin NH, Ferbas KG, Kitchen SG, Aldrovandi GM, Rimoin AW, Yang OO. PMID: 34159781.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCellsPHPublic Health
    32. Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 04; 17(4):e1009404. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 33793675; PMCID: PMC8016106.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. Loss of Anti-SARS-CoV-2 Antibodies in Mild Covid-19. Reply. N Engl J Med. 2020 10 22; 383(17):1697-1698. Yang OO, Ibarrondo FJ. PMID: 32966713.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsPHPublic Health
    34. Chimeric Antigen Receptors Targeting Human Cytomegalovirus. J Infect Dis. 2020 08 04; 222(5):853-862. Ali A, Chiuppesi F, Nguyen M, Hausner MA, Nguyen J, Kha M, Iniguez A, Wussow F, Diamond DJ, Yang OO. PMID: 32285133; PMCID: PMC7399702.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Rapid Decay of Anti-SARS-CoV-2 Antibodies in Persons with Mild Covid-19. N Engl J Med. 2020 09 10; 383(11):1085-1087. Ibarrondo FJ, Fulcher JA, Goodman-Meza D, Elliott J, Hofmann C, Hausner MA, Ferbas KG, Tobin NH, Aldrovandi GM, Yang OO. PMID: 32706954; PMCID: PMC7397184.
      View in: PubMed   Mentions: 607     Fields:    Translation:HumansCellsPHPublic Health
    36. Erratum to: Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir. J Infect Dis. 2020 06 11; 221(12):2083-2084. Brown TT, Moser C, Currier JS, Ribaudo HJ, Rothenberg J, Kelesidis T, Yang O, Dubé MP, Murphy RL, Stein JH, McComsey GA. PMID: 32022230; PMCID: PMC7457181.
      View in: PubMed   Mentions:    Fields:    
    37. A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity. AIDS Res Hum Retroviruses. 2020 02; 36(2):122-130. Ali A, Furler RL, Pedroza-Martins L, Colantonio AD, Anisman-Posner D, Bryson Y, Yang OO, Uittenbogaart CH. PMID: 31571497; PMCID: PMC7044772.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    38. Suboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific cytotoxic T lymphocyte clones. AIDS. 2019 08 01; 33(10):1565-1574. Grossman MA, Hofmann C, Ng HL, Yang OO. PMID: 31306165; PMCID: PMC7046083.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. Bioconjug Chem. 2019 08 21; 30(8):2216-2227. Fulcher JA, Tamshen K, Wollenberg AL, Kickhoefer VA, Mrazek J, Elliott J, Ibarrondo FJ, Anton PA, Rome LH, Maynard HD, Deming T, Yang OO. PMID: 31265254; PMCID: PMC7434464.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    40. A Flow Cytometric Method to Determine Transfection Efficiency. Bio Protoc. 2019 May 20; 9(10). Mu W, Homann S, Hofmann C, Gorin A, Huynh D, Yang OO, Kelesidis T. PMID: 32855997; PMCID: PMC7449265.
      View in: PubMed   Mentions: 1  
    41. Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates. Virus Genes. 2019 Aug; 55(4):541-544. Furler RL, Ali A, Yang OO, Nixon DF. PMID: 31093843; PMCID: PMC6640090.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    42. Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1. J Infect Dis. 2018 09 22; 218(9):1447-1452. Ali A, Ng HL, Blankson JN, Burton DR, Buckheit RW, Moldt B, Fulcher JA, Ibarrondo FJ, Anton PA, Yang OO. PMID: 29878133; PMCID: PMC6151090.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic Health
    43. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J Virol. 2018 08 15; 92(16). Balamurugan A, Ng HL, Yang OO. PMID: 29899094; PMCID: PMC6069174.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    44. CD8+ Cytotoxic T Lymphocyte Responses and Viral Epitope Escape in Acute HIV-1 Infection. Viral Immunol. 2018 09; 31(7):525-536. Kim J, De La Cruz J, Lam K, Ng H, Daar ES, Balamurugan A, Yang OO. PMID: 30059271; PMCID: PMC6145043.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Brief Report: Changes in Plasma RANKL-Osteoprotegerin in a Prospective, Randomized Clinical Trial of Initial Antiviral Therapy: A5260s. J Acquir Immune Defic Syndr. 2018 07 01; 78(3):362-366. Kelesidis T, Moser CB, Johnston E, Stein JH, Dube MP, Yang OO, McComsey GA, Currier JS, Brown TT. PMID: 29533303; PMCID: PMC5997510.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Solution Structures of Engineered Vault Particles. Structure. 2018 04 03; 26(4):619-626.e3. Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH. PMID: 29551289; PMCID: PMC5906032.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio. 2017 11 28; 8(6). Du Y, Zhang TH, Dai L, Zheng X, Gorin AM, Oishi J, Wu TT, Yoshizawa JM, Li X, Yang OO, Martinez-Maza O, Detels R, Sun R. PMID: 29184023; PMCID: PMC5705913.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection. J Virol. 2017 11 15; 91(22). Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR. PMID: 28878089; PMCID: PMC5660483.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsCTClinical Trials
    49. Were we prepared for PrEP? Five years of implementation. AIDS. 2017 10 23; 31(16):2303-2305. Weinstein M, Yang OO, Cohen AC. PMID: 28857829; PMCID: PMC5642332.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    50. A novel rapid and reproducible flow cytometric method for optimization of transfection efficiency in cells. PLoS One. 2017; 12(9):e0182941. Homann S, Hofmann C, Gorin AM, Nguyen HCX, Huynh D, Hamid P, Maithel N, Yacoubian V, Mu W, Kossyvakis A, Sen Roy S, Yang OO, Kelesidis T. PMID: 28863132; PMCID: PMC5580984.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    51. Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments. PLoS One. 2017; 12(8):e0182498. Dock J, Ramirez CM, Hultin L, Hausner MA, Hultin P, Elliott J, Yang OO, Anton PA, Jamieson BD, Effros RB. PMID: 28832609; PMCID: PMC5568404.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
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    175. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. Ali A, Pillai S, Ng H, Lubong R, Richman DD, Jamieson BD, Ding Y, McElrath MJ, Guatelli JC, Yang OO. PMID: 14530319.
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    176. Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL. J Immunol. 2003 Oct 01; 171(7):3718-24. Yang OO, Sarkis PT, Trocha A, Kalams SA, Johnson RP, Walker BD. PMID: 14500671.
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    177. The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses. 2003 Oct; 19(10):875-81. Münk C, Wei G, Yang OO, Waring AJ, Wang W, Hong T, Lehrer RI, Landau NR, Cole AM. PMID: 14585219.
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    178. Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods. 2003 Aug; 279(1-2):17-31. Shacklett BL, Yang O, Hausner MA, Elliott J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong JT, Nixon DF, Anton PA, Jamieson BD. PMID: 12969544.
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    180. Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. J Exp Med. 2003 May 19; 197(10):1365-75. Yang OO, Sarkis PT, Ali A, Harlow JD, Brander C, Kalams SA, Walker BD. PMID: 12743169; PMCID: PMC2193781.
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    181. Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol. 2003 Mar; 77(5):3077-83. Dagarag M, Ng H, Lubong R, Effros RB, Yang OO. PMID: 12584333; PMCID: PMC149786.
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    182. Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection. Virology. 2003 Feb 15; 306(2):371-5. Severino ME, Sarkis PT, Walker BD, Yang OO. PMID: 12642109.
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    183. Will we be able to 'spot' an effective HIV-1 vaccine? Trends Immunol. 2003 Feb; 24(2):67-72. Yang OO. PMID: 12547502.
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    184. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Lett. 2003 Jan 30; 535(1-3):195-9. Cole AM, Liao HI, Ganz T, Yang OO. PMID: 12560103.
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    186. Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. J Infect Dis. 2002 Apr 15; 185(8):1174-8. Yang OO, Garcia-Zepeda EA, Walker BD, Luster AD. PMID: 11930329.
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    187. Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1813-8. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI. PMID: 11854483; PMCID: PMC122276.
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    188. Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. J Virol. 2002 Feb; 76(4):1626-31. Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BD. PMID: 11799157; PMCID: PMC135916.
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    189. CD1d on myeloid dendritic cells stimulates cytokine secretion from and cytolytic activity of V alpha 24J alpha Q T cells: a feedback mechanism for immune regulation. J Immunol. 2000 Oct 01; 165(7):3756-62. Yang OO, Racke FK, Nguyen PT, Gausling R, Severino ME, Horton HF, Byrne MC, Strominger JL, Wilson SB. PMID: 11034380.
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