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Otto Orlean Yang

Title(s)Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone3107949491
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    Other Positions
    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    Dual CMV and HIV CARs for Cure of HIV
    NIH/NIAID R21AI136606Mar 5, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
    NIH/NIAID R01AI140775Jan 16, 2020 - Dec 31, 2024
    Role: Principal Investigator
    Los Angeles CRS for the MACS/WIHS Combined Cohort Study
    NIH/NHLBI U01HL146333Apr 1, 2019 - Mar 31, 2026
    Role: Co-Principal Investigator
    Chimeric Broadly Neutralizing Anti-HIV Antibodies
    NIH/NIAID R21AI131879May 11, 2018 - Apr 30, 2020
    Role: Principal Investigator
    CD4 T Cell Differentiation and Susceptibility to HIV-Specific CTL Killing
    NIH/NIAID R21AI122939Aug 16, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Dissection of HIV-1 CTL Escape Pathways
    NIH/NIDCR R01DE025166Sep 13, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Topical Microbicides: Targeted Intracellular Delivery
    NIH/NIAID R01AI112016Mar 1, 2014 - Feb 28, 2018
    Role: Principal Investigator
    Functional Assessment of CTL Anergy in HIV Infection
    NIH/NIAID R21AI110343Feb 1, 2014 - Jan 31, 2016
    Role: Principal Investigator
    Bio-Nanoparticles for HIV Antigen Delivery
    NIH/NIAID R21AI106528Apr 19, 2013 - Mar 31, 2015
    Role: Principal Investigator
    Mechanistic Studies of HIV-exposed Seronegative Individuals
    NIH/NIAID R56AI100638Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator
    Identifying and closing gaps in TCR coverage of HIV-1 escape
    NIH/NIAID R56AI093138Aug 1, 2011 - Jul 31, 2013
    Role: Principal Investigator
    TRANSLATIONAL AIDS AND VIRAL PATHOGENESIS TRAINING
    NIH/NIAID T32AI089398May 15, 2010 - Jul 31, 2020
    Role: Principal Investigator
    Addressing Intra-/Inter-Clade Diversity in HIV Vaccine Design by Immune Focusing
    NIH/NIAID R21AI087382Apr 12, 2010 - Mar 31, 2013
    Role: Principal Investigator
    Mucosal and Peripheral NK-T Cells in HIV Infection
    NIH/NIAID R21AI063974Apr 1, 2006 - Mar 31, 2008
    Role: Principal Investigator
    Immune Pressure on HIV-1 Nef by Cytotoxic T Lymphocytes
    NIH/NIAID R01AI051970Apr 1, 2002 - Jun 30, 2013
    Role: Principal Investigator
    HIV-1 Escape from Inhibition by Cytotoxic T Lymphocytes
    NIH/NIAID R01AI043203Apr 1, 1998 - Mar 31, 2013
    Role: Principal Investigator
    INHIBITION OF HIV 1 BY CYTOTOXIC T LYMPHOCYTES
    NIH/NIAID K08AI001413Aug 1, 1996 - Jun 30, 1999
    Role: Principal Investigator
    INHIBITION OF HIV-1 BY CYTOTOXIC T LYMPHOCYTES
    NIH/NIAID F32AI009270Jul 1, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Loss of Anti-SARS-CoV-2 Antibodies in Mild Covid-19. Reply. N Engl J Med. 2020 Sep 23; 383(16). Yang OO, Ibarrondo FJ. PMID: 32966713.
      View in: PubMed   Mentions:    Fields:    
    2. Chimeric Antigen Receptors Targeting Human Cytomegalovirus. J Infect Dis. 2020 Aug 04; 222(5):853-862. Ali A, Chiuppesi F, Nguyen M, Hausner MA, Nguyen J, Kha M, Iniguez A, Wussow F, Diamond DJ, Yang OO. PMID: 32285133.
      View in: PubMed   Mentions:    Fields:    
    3. Rapid Decay of Anti-SARS-CoV-2 Antibodies in Persons with Mild Covid-19. N Engl J Med. 2020 09 10; 383(11):1085-1087. Ibarrondo FJ, Fulcher JA, Goodman-Meza D, Elliott J, Hofmann C, Hausner MA, Ferbas KG, Tobin NH, Aldrovandi GM, Yang OO. PMID: 32706954.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsPHPublic Health
    4. Erratum to: Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir. J Infect Dis. 2020 Jun 11; 221(12):2083-2084. Brown TT, Moser C, Currier JS, Ribaudo HJ, Rothenberg J, Kelesidis T, Yang O, Dubé MP, Murphy RL, Stein JH, McComsey GA. PMID: 32022230.
      View in: PubMed   Mentions:    Fields:    
    5. A Novel HIV-1 Nef Mutation in a Primary Pediatric Isolate Impairs MHC-Class I Downregulation and Cytopathicity. AIDS Res Hum Retroviruses. 2020 02; 36(2):122-130. Ali A, Furler RL, Pedroza-Martins L, Colantonio AD, Anisman-Posner D, Bryson Y, Yang OO, Uittenbogaart CH. PMID: 31571497.
      View in: PubMed   Mentions:    Fields:    
    6. Suboptimal stimulation by weak agonist epitope variants does not drive dysfunction of HIV-1-specific cytotoxic T lymphocyte clones. AIDS. 2019 08 01; 33(10):1565-1574. Grossman MA, Hofmann C, Ng HL, Yang OO. PMID: 31306165.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. Bioconjug Chem. 2019 08 21; 30(8):2216-2227. Fulcher JA, Tamshen K, Wollenberg AL, Kickhoefer VA, Mrazek J, Elliott J, Ibarrondo FJ, Anton PA, Rome LH, Maynard HD, Deming T, Yang OO. PMID: 31265254.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. A Flow Cytometric Method to Determine Transfection Efficiency. Bio Protoc. 2019 May 20; 9(10). Mu W, Homann S, Hofmann C, Gorin A, Huynh D, Yang OO, Kelesidis T. PMID: 32855997.
      View in: PubMed   Mentions:
    9. Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates. Virus Genes. 2019 Aug; 55(4):541-544. Furler RL, Ali A, Yang OO, Nixon DF. PMID: 31093843.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Highly Attenuated Infection With a Vpr-Deleted Molecular Clone of Human Immunodeficiency Virus-1. J Infect Dis. 2018 09 22; 218(9):1447-1452. Ali A, Ng HL, Blankson JN, Burton DR, Buckheit RW, Moldt B, Fulcher JA, Ibarrondo FJ, Anton PA, Yang OO. PMID: 29878133.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    11. Cross-Reactivity against Multiple HIV-1 Epitopes Is Characteristic of HIV-1-Specific Cytotoxic T Lymphocyte Clones. J Virol. 2018 08 15; 92(16). Balamurugan A, Ng HL, Yang OO. PMID: 29899094.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. CD8+ Cytotoxic T Lymphocyte Responses and Viral Epitope Escape in Acute HIV-1 Infection. Viral Immunol. 2018 09; 31(7):525-536. Kim J, De La Cruz J, Lam K, Ng H, Daar ES, Balamurugan A, Yang OO. PMID: 30059271.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Brief Report: Changes in Plasma RANKL-Osteoprotegerin in a Prospective, Randomized Clinical Trial of Initial Antiviral Therapy: A5260s. J Acquir Immune Defic Syndr. 2018 07 01; 78(3):362-366. Kelesidis T, Moser CB, Johnston E, Stein JH, Dube MP, Yang OO, McComsey GA, Currier JS, Brown TT. PMID: 29533303.
      View in: PubMed   Mentions:
    14. Solution Structures of Engineered Vault Particles. Structure. 2018 04 03; 26(4):619-626.e3. Ding K, Zhang X, Mrazek J, Kickhoefer VA, Lai M, Ng HL, Yang OO, Rome LH, Zhou ZH. PMID: 29551289.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes. mBio. 2017 11 28; 8(6). Du Y, Zhang TH, Dai L, Zheng X, Gorin AM, Oishi J, Wu TT, Yoshizawa JM, Li X, Yang OO, Martinez-Maza O, Detels R, Sun R. PMID: 29184023.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection. J Virol. 2017 11 15; 91(22). Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR. PMID: 28878089.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCellsCTClinical Trials
    17. Were we prepared for PrEP? Five years of implementation. AIDS. 2017 10 23; 31(16):2303-2305. Weinstein M, Yang OO, Cohen AC. PMID: 28857829.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    18. A novel rapid and reproducible flow cytometric method for optimization of transfection efficiency in cells. PLoS One. 2017; 12(9):e0182941. Homann S, Hofmann C, Gorin AM, Nguyen HCX, Huynh D, Hamid P, Maithel N, Yacoubian V, Mu W, Kossyvakis A, Sen Roy S, Yang OO, Kelesidis T. PMID: 28863132.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartments. PLoS One. 2017; 12(8):e0182498. Dock J, Ramirez CM, Hultin L, Hausner MA, Hultin P, Elliott J, Yang OO, Anton PA, Jamieson BD, Effros RB. PMID: 28832609.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes. PLoS Pathog. 2017 Aug; 13(8):e1006541. Gorin AM, Du Y, Liu FY, Zhang TH, Ng HL, Hofmann C, Cumberland WG, Sun R, Yang OO. PMID: 28787455.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth. J Virol. 2017 08 15; 91(16). Balamurugan A, Claiborne D, Ng HL, Yang OO. PMID: 28592539.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Highly Human Immunodeficiency Virus-Exposed Seronegative Men Have Lower Mucosal Innate Immune Reactivity. AIDS Res Hum Retroviruses. 2017 08; 33(8):788-795. Fulcher JA, Romas L, Hoffman JC, Elliott J, Saunders T, Burgener AD, Anton PA, Yang OO. PMID: 28503933.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Demographics and natural history of HIV-1-infected spontaneous controllers of viremia. AIDS. 2017 05 15; 31(8):1091-1098. Yang OO, Cumberland WG, Escobar R, Liao D, Chew KW. PMID: 28301422.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. Clinical efficacy of gene-modified stem cells in adenosine deaminase-deficient immunodeficiency. J Clin Invest. 2017 May 01; 127(5):1689-1699. Shaw KL, Garabedian E, Mishra S, Barman P, Davila A, Carbonaro D, Shupien S, Silvin C, Geiger S, Nowicki B, Smogorzewska EM, Brown B, Wang X, de Oliveira S, Choi Y, Ikeda A, Terrazas D, Fu PY, Yu A, Fernandez BC, Cooper AR, Engel B, Podsakoff G, Balamurugan A, Anderson S, Muul L, Jagadeesh GJ, Kapoor N, Tse J, Moore TB, Purdy K, Rishi R, Mohan K, Skoda-Smith S, Buchbinder D, Abraham RS, Scharenberg A, Yang OO, Cornetta K, Gjertson D, Hershfield M, Sokolic R, Candotti F, Kohn DB. PMID: 28346229.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCellsCTClinical Trials
    25. Human immune compartment comparisons: Optimization of proliferative assays for blood and gut T lymphocytes. J Immunol Methods. 2017 06; 445:77-87. Dock J, Hultin L, Hultin P, Elliot J, Yang OO, Anton PA, Jamieson BD, Effros RB. PMID: 28336395.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Detection of Donor-Derived Microparticles in the Peripheral Blood of a Hand Transplant Recipient During Rejection. Transplant Direct. 2017 Mar; 3(3):e131. Kim JY, Kelesidis T, Yang OO. PMID: 28361115.
      View in: PubMed   Mentions:
    27. Risks Associated With Lentiviral Vector Exposures and Prevention Strategies. J Occup Environ Med. 2016 12; 58(12):1159-1166. Schlimgen R, Howard J, Wooley D, Thompson M, Baden LR, Yang OO, Christiani DC, Mostoslavsky G, Diamond DV, Duane EG, Byers K, Winters T, Gelfand JA, Fujimoto G, Hudson TW, Vyas JM. PMID: 27930472.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsPHPublic Health
    28. Oxidized lipoproteins are associated with markers of inflammation and immune activation in HIV-1 infection. AIDS. 2016 11 13; 30(17):2625-2633. Kelesidis T, Jackson N, McComsey GA, Wang X, Elashoff D, Dube MP, Brown TT, Yang OO, Stein JH, Currier JS. PMID: 27603288.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes. Nat Commun. 2016 10 18; 7:13223. Zhang X, Lai M, Chang W, Yu I, Ding K, Mrazek J, Ng HL, Yang OO, Maslov DA, Zhou ZH. PMID: 27752045.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Changes in plasma levels of oxidized lipoproteins and lipoprotein subfractions with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy and associations with common carotid artery intima-media thickness: ACTG 5260s. Antivir Ther. 2017; 22(2):113-126. Kelesidis T, Tran TTT, Brown TT, Moser C, Ribaudo HJ, Dube MP, Yang OO, McComsey GA, Stein JH, Currier JS. PMID: 27661466.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. Telmisartan increases vascular reparative capacity in older HIV-infected adults: a pilot study. HIV Clin Trials. 2016 11; 17(6):225-232. Lake JE, Seang S, Kelesidis T, Currier JS, Yang OO. PMID: 27658740.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Reimann's "Habitual Hyperthermia" Responding to Hormone Therapy. Open Forum Infect Dis. 2016 Sep; 3(3):ofw127. Yang OO, Currier JS. PMID: 27800522.
      View in: PubMed   Mentions:
    33. HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies. J Virol. 2016 08 01; 90(15):6999-7006. Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO. PMID: 27226366.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    34. Changes in Markers of T-Cell Senescence and Exhaustion With Atazanavir-, Raltegravir-, and Darunavir-Based Initial Antiviral Therapy: ACTG 5260s. J Infect Dis. 2016 09 01; 214(5):748-52. Kelesidis T, Moser C, Stein JH, Brown TT, Tran TT, Ribaudo HJ, Dube MP, Yang OO, Currier JS, McComsey GA. PMID: 27354367.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Supranormal thymic output up to 2 decades after HIV-1 infection. AIDS. 2016 Mar 13; 30(5):701-11. Aguilera-Sandoval CR, Yang OO, Jojic N, Lovato P, Chen DY, Boechat MI, Cooper P, Zuo J, Ramirez C, Belzer M, Church JA, Krogstad P. PMID: 26730570.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    36. Correction: Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand. PLoS One. 2015; 10(12):e0146008. Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S, Yang OO. PMID: 26699875.
      View in: PubMed   Mentions:    Fields:    
    37. Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand. PLoS One. 2015; 10(8):e0136235. Kim JY, Balamurugan A, Azari K, Hofmann C, Ng HL, Reed EF, McDiarmid S, Yang OO. PMID: 26287728.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    38. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. PMID: 26050990.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    39. Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. J Virol. 2015 Aug; 89(16):8643-50. Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, Pal R, Kwa S, Ding S, Yang OO, Fouda GG, Le Grand R, Bolton D, Esteban M, Phogat S, Roederer M, Amara RR, Picker LJ, Seder RA, McElrath MJ, Barnett S, Permar SR, Shattock R, DeVico AL, Felber BK, Pavlakis GN, Pantaleo G, Korber BT, Montefiori DC, Tomaras GD. PMID: 26018159.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    40. Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4? CAR from HIV-1 infection and alleviates impairment of cell proliferation. Biochem Biophys Res Commun. 2015 Jul 31; 463(3):216-21. Kamata M, Kim PY, Ng HL, Ringpis GE, Kranz E, Chan J, O'Connor S, Yang OO, Chen IS. PMID: 25998390.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    41. Changes in Bone Mineral Density After Initiation of Antiretroviral Treatment With Tenofovir Disoproxil Fumarate/Emtricitabine Plus Atazanavir/Ritonavir, Darunavir/Ritonavir, or Raltegravir. J Infect Dis. 2015 Oct 15; 212(8):1241-9. Brown TT, Moser C, Currier JS, Ribaudo HJ, Rothenberg J, Kelesidis T, Yang O, Dubé MP, Murphy RL, Stein JH, McComsey GA. PMID: 25948863.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    42. Changes in Inflammation and Immune Activation With Atazanavir-, Raltegravir-, Darunavir-Based Initial Antiviral Therapy: ACTG 5260s. Clin Infect Dis. 2015 Aug 15; 61(4):651-60. Kelesidis T, Tran TT, Stein JH, Brown TT, Moser C, Ribaudo HJ, Dube MP, Murphy R, Yang OO, Currier JS, McComsey GA. PMID: 25904376.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    43. T lymphocyte density and distribution in human colorectal mucosa, and inefficiency of current cell isolation protocols. PLoS One. 2015; 10(4):e0122723. Preza GC, Yang OO, Elliott J, Anton PA, Ochoa MT. PMID: 25856343.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    44. Adenovirus vectors as HIV-1 vaccines: where are we? What next? AIDS. 2015 Feb 20; 29(4):395-400. D'Souza MP, Yang OO. PMID: 25630039.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance. J Virol. 2015 Jan 15; 89(2):1195-204. Yang OO, Ali A, Kasahara N, Faure-Kumar E, Bae JY, Picker LJ, Park H. PMID: 25378501.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    46. A high throughput biochemical fluorometric method for measuring lipid peroxidation in HDL. PLoS One. 2014; 9(11):e111716. Kelesidis T, Roberts CK, Huynh D, Martínez-Maza O, Currier JS, Reddy ST, Yang OO. PMID: 25368900.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    47. Seminal plasma HIV-1 RNA concentration is strongly associated with altered levels of seminal plasma interferon-?, interleukin-17, and interleukin-5. AIDS Res Hum Retroviruses. 2014 Nov; 30(11):1082-8. Hoffman JC, Anton PA, Baldwin GC, Elliott J, Anisman-Posner D, Tanner K, Grogan T, Elashoff D, Sugar C, Yang OO, Hoffman RM. PMID: 25209674.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    48. Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial. AIDS Res Hum Retroviruses. 2014 Oct; 30(10):988-95. Yang OO, Kelesidis T, Cordova R, Khanlou H. PMID: 25127924.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    49. Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem Cells. 2014 Sep; 32(9):2386-96. Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang OO, Crooks GM. PMID: 24801626.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    50. Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing. AIDS Res Hum Retroviruses. 2014 Aug; 30(8):806-11. Al-Mawsawi LQ, Wu NC, De La Cruz J, Shi VC, Wu TT, Daar ES, Lewis MJ, Yang OO, Sun R. PMID: 24914638.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    51. Role of RANKL-RANK/osteoprotegerin pathway in cardiovascular and bone disease associated with HIV infection. AIDS Rev. 2014 Jul-Sep; 16(3):123-33. Kelesidis T, Currier JS, Yang OO, Brown TT. PMID: 25102334.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    52. HIV-1 quasispecies delineation by tag linkage deep sequencing. PLoS One. 2014; 9(5):e97505. Wu NC, De La Cruz J, Al-Mawsawi LQ, Olson CA, Qi H, Luan HH, Nguyen N, Du Y, Le S, Wu TT, Li X, Lewis MJ, Yang OO, Sun R. PMID: 24842159.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    53. Ineffectual targeting of HIV-1 Nef by cytotoxic T lymphocytes in acute infection results in no functional impairment or viremia reduction. J Virol. 2014 Jul; 88(14):7881-92. De La Cruz J, Vollbrecht T, Frohnen P, Ng HL, Daar ES, Yang OO, Lewis MJ. PMID: 24789790.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    54. Differential blood and mucosal immune responses against an HIV-1 vaccine administered via inguinal or deltoid injection. PLoS One. 2014; 9(2):e88621. Yang OO, Ibarrondo FJ, Price C, Hultin LE, Elliott J, Hultin PM, Shih R, Hausner MA, Ng HL, Hoffman J, Jamieson BD, Anton PA. PMID: 24558403.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    55. HDL redox activity is increased in HIV-infected men in association with macrophage activation and non-calcified coronary atherosclerotic plaque. Antivir Ther. 2014; 19(8):805-811. Zanni MV, Kelesidis T, Fitzgerald ML, Lo J, Abbara S, Wai B, Marmarelis E, Hernandez NJ, Yang OO, Currier JS, Grinspoon SK. PMID: 24535655.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    56. Antigen-presenting cell candidates for HIV-1 transmission in human distal colonic mucosa defined by CD207 dendritic cells and CD209 macrophages. AIDS Res Hum Retroviruses. 2014 Mar; 30(3):241-9. Preza GC, Tanner K, Elliott J, Yang OO, Anton PA, Ochoa MT. PMID: 24134315.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    57. Natural killer T cells in advanced melanoma patients treated with tremelimumab. PLoS One. 2013; 8(10):e76829. Ibarrondo FJ, Yang OO, Chodon T, Avramis E, Lee Y, Sazegar H, Jalil J, Chmielowski B, Koya RC, Schmid I, Gomez-Navarro J, Jamieson BD, Ribas A, Comin-Anduix B. PMID: 24167550.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsCTClinical Trials
    58. HIV-1 Nef sequence and functional compartmentalization in the gut is not due to differential cytotoxic T lymphocyte selective pressure. PLoS One. 2013; 8(9):e75620. Lewis MJ, Frohnen P, Ibarrondo FJ, Reed D, Iyer V, Ng HL, Elliott J, Yang OO, Anton P. PMID: 24058696.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsCTClinical Trials
    59. Untrained young men have dysfunctional HDL compared with strength-trained men irrespective of body weight status. J Appl Physiol (1985). 2013 Oct 01; 115(7):1043-9. Roberts CK, Katiraie M, Croymans DM, Yang OO, Kelesidis T. PMID: 23887902.
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    120. Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes. AIDS. 2006 Apr 04; 20(6):939-42. Pedroza-Martins L, Boscardin WJ, Anisman-Posner DJ, Redsar BN, Bryson YJ, Yang OO, Uittenbogaart CH. PMID: 16549983.
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    121. Transience of vaccine-induced HIV-1-specific CTL and definition of vaccine "response". Vaccine. 2006 Apr 24; 24(17):3426-31. Jamieson BD, Ibarrondo FJ, Wong JT, Hausner MA, Ng HL, Fuerst M, Price C, Shih R, Elliott J, Hultin PM, Hultin LE, Anton PA, Yang OO. PMID: 16545508.
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    122. Involvement of claudin-7 in HIV infection of CD4(-) cells. Retrovirology. 2005 Dec 20; 2:79. Zheng J, Xie Y, Campbell R, Song J, Massachi S, Razi M, Chiu R, Berenson J, Yang OO, Chen IS, Pang S. PMID: 16368003.
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    123. Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins. J Virol. 2005 Dec; 79(24):15368-75. Yang OO, Church J, Kitchen CM, Kilpatrick R, Ali A, Geng Y, Killian MS, Sabado RL, Ng H, Suen J, Bryson Y, Jamieson BD, Krogstad P. PMID: 16306608.
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    124. A novel small reporter gene and HIV-1 fitness assay. J Virol Methods. 2006 Apr; 133(1):41-7. Ali A, Yang OO. PMID: 16307801.
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    125. How many human immunodeficiency virus type 1-infected target cells can a cytotoxic T-lymphocyte kill? J Virol. 2005 Nov; 79(21):13579-86. Wick WD, Yang OO, Corey L, Self SG. PMID: 16227278.
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    126. Evasion of cytotoxic T lymphocytes is a functional constraint maintaining HIV-1 Nef expression. Eur J Immunol. 2005 Nov; 35(11):3221-8. Ali A, Ng HL, Dagarag MD, Yang OO. PMID: 16206233.
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    127. Effects of HIV-1 infection on lymphocyte phenotypes in blood versus lymph nodes. . 2005 Aug 15; 39(5):507-18. Yang OO, Ferbas JJ, Hausner MA, Hultin LE, Hultin PM, McFadden D, Sawicki M, Detels R, Majchrowicz M, Matud JL, Giorgi JV, Jamieson BD. PMID: 16044000.
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    128. Clonal breadth of the HIV-1-specific T-cell receptor repertoire in vivo as determined by subtractive analysis. AIDS. 2005 Jun 10; 19(9):887-96. Killian MS, Sabado RL, Kilpatrick S, Hausner MA, Jamieson BD, Yang OO. PMID: 15905669.
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    129. Parallel human immunodeficiency virus type 1-specific CD8+ T-lymphocyte responses in blood and mucosa during chronic infection. J Virol. 2005 Apr; 79(7):4289-97. Ibarrondo FJ, Anton PA, Fuerst M, Ng HL, Wong JT, Matud J, Elliott J, Shih R, Hausner MA, Price C, Hultin LE, Hultin PM, Jamieson BD, Yang OO. PMID: 15767429.
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    130. Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes. Virology. 2005 Feb 05; 332(1):16-9. Yang OO, Lin H, Dagarag M, Ng HL, Effros RB, Uittenbogaart CH. PMID: 15661136.
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    131. Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains. J Virol. 2005 Jan; 79(2):860-8. Yang OO, Daar ES, Jamieson BD, Balamurugan A, Smith DM, Pitt JA, Petropoulos CJ, Richman DD, Little SJ, Brown AJ. PMID: 15613314.
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    132. Ethanol stimulation of HIV infection of oral epithelial cells. . 2004 Dec 01; 37(4):1445-53. Zheng J, Yang OO, Xie Y, Campbell R, Chen IS, Pang S. PMID: 15602121.
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    134. Culturing of HIV-1-specific cytotoxic T lymphocytes with interleukin-7 and interleukin-15. Virology. 2004 Aug 01; 325(2):175-80. Lubong R, Ng HL, Uittenbogaart CH, Yang OO. PMID: 15246257.
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    135. Beyond help: direct effector functions of human immunodeficiency virus type 1-specific CD4(+) T cells. J Virol. 2004 Aug; 78(16):8844-51. Norris PJ, Moffett HF, Yang OO, Kaufmann DE, Clark MJ, Addo MM, Rosenberg ES. PMID: 15280492.
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    136. CTL ontogeny and viral escape: implications for HIV-1 vaccine design. Trends Immunol. 2004 Mar; 25(3):138-42. Yang OO. PMID: 15036041.
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    137. Persistent alterations in the T-cell repertoires of HIV-1-infected and at-risk uninfected men. AIDS. 2004 Jan 23; 18(2):161-70. Killian MS, Monteiro J, Matud J, Hultin LE, Hausner MA, Yang OO, Gregersen PK, Detels R, Giorgi JV, Jamieson BD. PMID: 15075532.
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    138. Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol. 2004 Jan; 78(2):561-7. Ali A, Lubong R, Ng H, Brooks DG, Zack JA, Yang OO. PMID: 14694087.
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    139. Epitope escape mutation and decay of human immunodeficiency virus type 1-specific CTL responses. J Immunol. 2003 Nov 15; 171(10):5372-9. Jamieson BD, Yang OO, Hultin L, Hausner MA, Hultin P, Matud J, Kunstman K, Killian S, Altman J, Kommander K, Korber B, Giorgi J, Wolinsky S. PMID: 14607940.
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    140. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. Ali A, Pillai S, Ng H, Lubong R, Richman DD, Jamieson BD, Ding Y, McElrath MJ, Guatelli JC, Yang OO. PMID: 14530319.
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    141. Impacts of avidity and specificity on the antiviral efficiency of HIV-1-specific CTL. J Immunol. 2003 Oct 01; 171(7):3718-24. Yang OO, Sarkis PT, Trocha A, Kalams SA, Johnson RP, Walker BD. PMID: 14500671.
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    142. The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses. 2003 Oct; 19(10):875-81. Münk C, Wei G, Yang OO, Waring AJ, Wang W, Hong T, Lehrer RI, Landau NR, Cole AM. PMID: 14585219.
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    143. Optimization of methods to assess human mucosal T-cell responses to HIV infection. J Immunol Methods. 2003 Aug; 279(1-2):17-31. Shacklett BL, Yang O, Hausner MA, Elliott J, Hultin L, Price C, Fuerst M, Matud J, Hultin P, Cox C, Ibarrondo J, Wong JT, Nixon DF, Anton PA, Jamieson BD. PMID: 12969544.
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    144. Half-genome human immunodeficiency virus type 1 constructs for rapid production of reporter viruses. J Virol Methods. 2003 Jun 30; 110(2):137-42. Ali A, Jamieson BD, Yang OO. PMID: 12798240.
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    145. Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes. J Exp Med. 2003 May 19; 197(10):1365-75. Yang OO, Sarkis PT, Ali A, Harlow JD, Brander C, Kalams SA, Walker BD. PMID: 12743169.
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    146. Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol. 2003 Mar; 77(5):3077-83. Dagarag M, Ng H, Lubong R, Effros RB, Yang OO. PMID: 12584333.
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    147. Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection. Virology. 2003 Feb 15; 306(2):371-5. Severino ME, Sarkis PT, Walker BD, Yang OO. PMID: 12642109.
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    148. Will we be able to 'spot' an effective HIV-1 vaccine? Trends Immunol. 2003 Feb; 24(2):67-72. Yang OO. PMID: 12547502.
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    149. Antibacterial activity of peptides derived from envelope glycoproteins of HIV-1. FEBS Lett. 2003 Jan 30; 535(1-3):195-9. Cole AM, Liao HI, Ganz T, Yang OO. PMID: 12560103.
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    150. TCR gamma delta+ and CD161+ thymocytes express HIV-1 in the SCID-hu mouse, potentially contributing to immune dysfunction in HIV infection. J Immunol. 2002 Nov 01; 169(9):5338-46. Gurney KB, Yang OO, Wilson SB, Uittenbogaart CH. PMID: 12391255.
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    151. Immunologic profile of highly exposed yet HIV type 1-seronegative men. AIDS Res Hum Retroviruses. 2002 Sep 20; 18(14):1051-65. Yang OO, Boscardin WJ, Matud J, Hausner MA, Hultin LE, Hultin PM, Shih R, Ferbas J, Siegal FP, Shodell M, Shearer GM, Grene E, Carrington M, O'Brien S, Price CB, Detels R, Jamieson BD, Giorgi JV. PMID: 12396457.
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    152. gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1. . 2002 May 01; 30(1):1-8. Chow YH, Yu D, Zhang JY, Xie Y, Wei OL, Chiu C, Foroohar M, Yang OO, Park NH, Chen IS, Pang S. PMID: 12048357.
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    153. Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. J Infect Dis. 2002 Apr 15; 185(8):1174-8. Yang OO, Garcia-Zepeda EA, Walker BD, Luster AD. PMID: 11930329.
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    154. Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1813-8. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI. PMID: 11854483.
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    155. Nef-mediated resistance of human immunodeficiency virus type 1 to antiviral cytotoxic T lymphocytes. J Virol. 2002 Feb; 76(4):1626-31. Yang OO, Nguyen PT, Kalams SA, Dorfman T, Göttlinger HG, Stewart S, Chen IS, Threlkeld S, Walker BD. PMID: 11799157.
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    156. CD1d on myeloid dendritic cells stimulates cytokine secretion from and cytolytic activity of V alpha 24J alpha Q T cells: a feedback mechanism for immune regulation. J Immunol. 2000 Oct 01; 165(7):3756-62. Yang OO, Racke FK, Nguyen PT, Gausling R, Severino ME, Horton HF, Byrne MC, Strominger JL, Wilson SB. PMID: 11034380.
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