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Zack Jerome

Title(s)Professor, Medicine
Phone310-825-6192
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    Other Positions
    Title(s)Professor and Chair, Microbiology Immunology & Molecular Genetics

    Title(s)Associate Director, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research

    Title(s)Co-Director, UCLA AIDS Institute


    Collapse Research 
    Collapse Research Activities and Funding
    Defining Factors Controlling HIV Rebound
    NIH/NIAID P01AI131294Aug 10, 2017 - Jul 31, 2022
    Role: Principal Investigator
    HIV latency reversal through novel, potent PKC modulators
    NIH/NIAID R01AI124743Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    HIV Infection of Hematopoietic Stem/Progenitor Cells (HSPC) in Bone Marrow
    NIH/NIAID R01AI103385Jul 23, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Control of Multineage Human ESC Differentiation
    NIH/NIGMS P01GM081621Aug 1, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Targeting HIV Reservoirs in vitro and in vivo
    NIH/NIAID R01AI070010Mar 1, 2006 - Jul 31, 2015
    Role: Principal Investigator
    Thymic Function and Immune Reconstitution for AIDS
    NIH/NIAID R21AI061660Jan 15, 2006 - Dec 31, 2007
    Role: Principal Investigator
    Palm Springs Symposia on HIV/AIDS
    NIH/NIAID R13AI068368Jan 1, 2006 - Feb 28, 2022
    Role: Principal Investigator
    CD4 EXPRESSION ON CD8+ CELLS
    NIH/NIAID R01AI048392Jan 1, 2001 - Dec 31, 2005
    Role: Principal Investigator
    CYTOKINE THERAPY FOR HIV INFECTION IN VIVO
    NIH/NHLBI R01HL055205Sep 30, 1995 - Jul 31, 1999
    Role: Principal Investigator
    In Vivo Pathogenesis of HIV-1
    NIH/NIAID R37AI036059Sep 1, 1994 - May 31, 2008
    Role: Principal Investigator
    IN VIVO PATHOGENESIS OF HIV-1
    NIH/NIAID R01AI036059Sep 1, 1994 - May 31, 1998
    Role: Principal Investigator
    Immune Reconstitution Following HIV Infection
    NIH/NIAID R01AI036554Aug 1, 1994 - Nov 30, 2007
    Role: Principal Investigator
    HIV-1 REVERSE TRANSCRIPTION IN QUIESCENT LYMPHOCYTES
    NIH/NIAID R29AI033259Jan 1, 1993 - Dec 31, 1997
    Role: Principal Investigator
    UCLA Center for AIDS Research (CFAR)
    NIH/NIAID P30AI028697Sep 1, 1991 - Feb 28, 2019
    Role: Principal Investigator
    HIV LATENCY/PERSISTENCE IN PRIMARY CELLS
    NIH/NIAID F32AI008145Feb 28, 1989 - Feb 29, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Galli V, Nixon CC, Strbo N, Artesi M, de Castro-Amarante MF, McKinnon K, Fujikawa D, Omsland M, Washington-Parks R, Romero L, Caruso B, Durkin K, Brown S, Karim B, Vaccari M, Jacobson S, Zack JA, Van den Broeke A, Pise-Masison C, Franchini G. Essential Role of Human T Cell Leukemia Virus Type 1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice. J Virol. 2019 Oct 01; 93(19). PMID: 31315992.
      View in: PubMed
    2. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 Oct 03; 25(4):542-557.e9. PMID: 31495780.
      View in: PubMed
    3. Llewellyn GN, Seclén E, Wietgrefe S, Liu S, Chateau M, Pei H, Perkey K, Marsden MD, Hinkley SJ, Paschon DE, Holmes MC, Zack JA, Louie SG, Haase AT, Cannon PM. Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells. J Virol. 2019 May 15; 93(10). PMID: 30842333.
      View in: PubMed
    4. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2019 Feb 12; 10(1):52. PMID: 30755264.
      View in: PubMed
    5. Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA. Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. Virology. 2018 07; 520:83-93. PMID: 29800728.
      View in: PubMed
    6. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2018 03; 14(3):e1006891. PMID: 29529058.
      View in: PubMed
    7. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2017 12; 13(12):e1006753. PMID: 29284044.
      View in: PubMed
    8. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017 10 02; 8(1):217. PMID: 28969679.
      View in: PubMed
    9. Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA. In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication. PLoS Pathog. 2017 Sep; 13(9):e1006575. PMID: 28934369.
      View in: PubMed
    10. Marsden MD, Zack JA. Humanized Mouse Models for Human Immunodeficiency Virus Infection. Annu Rev Virol. 2017 09 29; 4(1):393-412. PMID: 28746819.
      View in: PubMed
    11. Carrillo MA, Zhen A, Zack JA, Kitchen SG. New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV. Transl Res. 2017 09; 187:83-92. PMID: 28755872.
      View in: PubMed
    12. Kitchen SG, Zack JA. Engineering HIV-Specific Immunity with Chimeric Antigen Receptors. AIDS Patient Care STDS. 2016 12; 30(12):556-561. PMID: 27905838.
      View in: PubMed
    13. Smith DJ, Lin LJ, Moon H, Pham AT, Wang X, Liu S, Ji S, Rezek V, Shimizu S, Ruiz M, Lam J, Janzen DM, Memarzadeh S, Kohn DB, Zack JA, Kitchen SG, An DS, Yang L. Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy. Stem Cells Dev. 2016 12 15; 25(24):1863-1873. PMID: 27608727.
      View in: PubMed
    14. Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO. HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies. J Virol. 2016 08 01; 90(15):6999-7006. PMID: 27226366.
      View in: PubMed
    15. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. PMID: 27400264.
      View in: PubMed
    16. Zhen A, Rezek V, Youn C, Rick J, Lam B, Chang N, Zack J, Kamata M, Kitchen S. Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model. J Vis Exp. 2016 07 02; (113). PMID: 27404517.
      View in: PubMed
    17. Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016 06; 18(6):595-606. PMID: 27183470.
      View in: PubMed
    18. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell. 2016 Apr 07; 18(4):533-40. PMID: 26877224.
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    19. Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):109-19. PMID: 26670361.
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    20. Sanchez DJ, Miranda D, Marsden MD, Dizon TM, Bontemps JR, Davila SJ, Del Mundo LE, Ha T, Senaati A, Zack JA, Cheng G. Disruption of Type I Interferon Induction by HIV Infection of T Cells. PLoS One. 2015; 10(9):e0137951. PMID: 26375588.
      View in: PubMed
    21. Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN. Corrigendum: Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor. Sci Rep. 2015 Jul 13; 5:9798. PMID: 26166708.
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    22. Kim SG, Lowe EL, Dixit D, Youn CS, Kim IJ, Jung JB, Rovner R, Zack JA, Vatakis DN. Cocaine-mediated impact on HIV infection in humanized BLT mice. Sci Rep. 2015 Jun 18; 5:10010. PMID: 26084721.
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    23. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. PMID: 26050990.
      View in: PubMed
    24. McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. J Clin Invest. 2015 May; 125(5):1815-26. PMID: 25822024.
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    25. Menon T, Firth AL, Scripture-Adams DD, Galic Z, Qualls SJ, Gilmore WB, Ke E, Singer O, Anderson LS, Bornzin AR, Alexander IE, Zack JA, Verma IM. Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs. Cell Stem Cell. 2015 Apr 02; 16(4):367-72. PMID: 25772073.
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    26. Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN. Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Sci Rep. 2015 Mar 02; 5:8670. PMID: 25728014.
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    27. Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen IS, An DS. RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice. Mol Ther Nucleic Acids. 2015 Feb 17; 4:e227. PMID: 25689223.
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    28. Marsden MD, Zack JA. Double trouble: HIV latency and CTL escape. Cell Host Microbe. 2015 Feb 11; 17(2):141-2. PMID: 25674977.
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    29. Marsden MD, Zack JA. Studies of retroviral infection in humanized mice. Virology. 2015 May; 479-480:297-309. PMID: 25680625.
      View in: PubMed
    30. Marsden MD, Zack JA. Experimental Approaches for Eliminating Latent HIV. For Immunopathol Dis Therap. 2015; 6(1-2):91-99. PMID: 28191361.
      View in: PubMed
    31. Marsden MD, Zack JA. Neutralizing the HIV reservoir. Cell. 2014 Aug 28; 158(5):971-972. PMID: 25171398.
      View in: PubMed
    32. Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS Nano. 2014 Aug 26; 8(8):7723-32. PMID: 25061969.
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    33. Zhen A, Krutzik SR, Levin BR, Kasparian S, Zack JA, Kitchen SG. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol. 2014 Sep 01; 88(17):9934-46. PMID: 24942581.
      View in: PubMed
    34. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res. 2014 May 01; 20(9):2457-65. PMID: 24634374.
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    35. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status. Stem Cell Res Ther. 2013 Jul 26; 4(4):87. PMID: 23890092.
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    36. Nixon CC, Vatakis DN, Reichelderfer SN, Dixit D, Kim SG, Uittenbogaart CH, Zack JA. HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice. Blood. 2013 Sep 26; 122(13):2195-204. PMID: 23886835.
      View in: PubMed
    37. Kim SG, Jung JB, Dixit D, Rovner R, Zack JA, Baldwin GC, Vatakis DN. Cocaine exposure enhances permissiveness of quiescent T cells to HIV infection. J Leukoc Biol. 2013 Oct; 94(4):835-43. PMID: 23817564.
      View in: PubMed
    38. Beans EJ, Fournogerakis D, Gauntlett C, Heumann LV, Kramer R, Marsden MD, Murray D, Chun TW, Zack JA, Wender PA. Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11698-703. PMID: 23812750.
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    39. Marsden MD, Zack JA. HIV/AIDS eradication. Bioorg Med Chem Lett. 2013 Jul 15; 23(14):4003-10. PMID: 23735743.
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    40. Zack JA, Kim SG, Vatakis DN. HIV restriction in quiescent CD4? T cells. Retrovirology. 2013 Apr 04; 10:37. PMID: 23557201.
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    41. Vatakis DN, Arumugam B, Kim SG, Bristol G, Yang O, Zack JA. Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression. Mol Ther. 2013 May; 21(5):1055-63. PMID: 23481324.
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    42. Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity. 2013 Jan 24; 38(1):92-105. PMID: 23273844.
      View in: PubMed
    43. Vatakis DN, Bristol GC, Kim SG, Levin B, Liu W, Radu CG, Kitchen SG, Zack JA. Using the BLT humanized mouse as a stem cell based gene therapy tumor model. J Vis Exp. 2012 Dec 18; (70):e4181. PMID: 23271478.
      View in: PubMed
    44. Marsden MD, Krogstad PA, Zack JA. Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens. Antivir Ther. 2012; 17(7):1375-9. PMID: 22820096.
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    45. DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA. Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem. 2012 Sep; 4(9):705-10. PMID: 22914190.
      View in: PubMed
    46. Kitchen SG, Levin BR, Bristol G, Rezek V, Kim S, Aguilera-Sandoval C, Balamurugan A, Yang OO, Zack JA. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells. PLoS Pathog. 2012; 8(4):e1002649. PMID: 22511873.
      View in: PubMed
    47. Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE. From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols. Stem Cells Transl Med. 2012 Jan; 1(1):36-43. PMID: 23197638.
      View in: PubMed
    48. Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):E1408-16. PMID: 22123951.
      View in: PubMed
    49. Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA. HIV latency in the humanized BLT mouse. J Virol. 2012 Jan; 86(1):339-47. PMID: 22072769.
      View in: PubMed
    50. Marban C, Su T, Ferrari R, Li B, Vatakis D, Pellegrini M, Zack JA, Rohr O, Kurdistani SK. Genome-wide binding map of the HIV-1 Tat protein to the human genome. PLoS One. 2011; 6(11):e26894. PMID: 22073215.
      View in: PubMed
    51. Marsden MD, Burke BP, Zack JA. HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes. Virology. 2011 Sep 01; 417(2):394-9. PMID: 21777932.
      View in: PubMed
    52. Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP. Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt. Stem Cells Int. 2011; 2011:393698. PMID: 21716651.
      View in: PubMed
    53. Marsden MD, Avancena P, Kitchen CM, Hubbard T, Zack JA. Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages. Antimicrob Agents Chemother. 2011 Aug; 55(8):3696-702. PMID: 21628534.
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    54. Kovochich M, Marsden MD, Zack JA. Activation of latent HIV using drug-loaded nanoparticles. PLoS One. 2011 Apr 05; 6(4):e18270. PMID: 21483687.
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    55. Kitchen SG, Zack JA. Stem cell-based approaches to treating HIV infection. Curr Opin HIV AIDS. 2011 Jan; 6(1):68-73. PMID: 21242896.
      View in: PubMed
    56. Vatakis DN, Nixon CC, Zack JA. Quiescent T cells and HIV: an unresolved relationship. Immunol Res. 2010 Dec; 48(1-3):110-21. PMID: 20725862.
      View in: PubMed
    57. Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. Female human iPSCs retain an inactive X chromosome. Cell Stem Cell. 2010 Sep 03; 7(3):329-42. PMID: 20727844.
      View in: PubMed
    58. Epeldegui M, Thapa DR, De la Cruz J, Kitchen S, Zack JA, Martínez-Maza O. CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes. PLoS One. 2010 Jul 06; 5(7):e11448. PMID: 20625427.
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    59. Brown HJ, Peng L, Harada JN, Walker JR, Cole S, Lin SF, Zack JA, Chanda SK, Sun R. Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator. J Biol Chem. 2010 Aug 13; 285(33):25139-53. PMID: 20516076.
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    60. Sundaravaradan V, Mehta R, Harris DT, Zack JA, Ahmad N. Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells. Virology. 2010 Apr 25; 400(1):32-43. PMID: 20138641.
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    61. Marsden MD, Zack JA. Establishment and maintenance of HIV latency: model systems and opportunities for intervention. Future Virol. 2010 Jan 01; 5(1):97-109. PMID: 21318097.
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    62. Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 2010 Feb 25; 115(8):1534-44. PMID: 20018916.
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    63. Kitchen SG, Bennett M, Galic Z, Kim J, Xu Q, Young A, Lieberman A, Joseph A, Goldstein H, Ng H, Yang O, Zack JA. Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice. PLoS One. 2009 Dec 07; 4(12):e8208. PMID: 19997617.
      View in: PubMed
    64. Vatakis DN, Kim S, Kim N, Chow SA, Zack JA. Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells. J Virol. 2009 Jun; 83(12):6222-33. PMID: 19369341.
      View in: PubMed
    65. Bernstein HB, Wang G, Plasterer MC, Zack JA, Ramasastry P, Mumenthaler SM, Kitchen CM. CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function. Virology. 2009 Apr 25; 387(1):59-66. PMID: 19251297.
      View in: PubMed
    66. Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, Bloch M, Lalezari J, Becker S, Thornton L, Akil B, Khanlou H, Finlayson R, McFarlane R, Smith DE, Garsia R, Ma D, Law M, Murray JM, von Kalle C, Ely JA, Patino SM, Knop AE, Wong P, Todd AV, Haughton M, Fuery C, Macpherson JL, Symonds GP, Evans LA, Pond SM, Cooper DA. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells. Nat Med. 2009 Mar; 15(3):285-92. PMID: 19219022.
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    67. Vatakis DN, Nixon CC, Bristol G, Zack JA. Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents. J Virol. 2009 Apr; 83(7):3374-8. PMID: 19129455.
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    68. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark AT. A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells. 2009 Jan; 27(1):18-28. PMID: 19224508.
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    69. Galic Z, Kitchen SG, Subramanian A, Bristol G, Marsden MD, Balamurugan A, Kacena A, Yang O, Zack JA. Generation of T lineage cells from human embryonic stem cells in a feeder free system. Stem Cells. 2009 Jan; 27(1):100-7. PMID: 18974209.
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    70. Subramanian A, Guo B, Marsden MD, Galic Z, Kitchen S, Kacena A, Brown HJ, Cheng G, Zack JA. Macrophage differentiation from embryoid bodies derived from human embryonic stem cells. J Stem Cells. 2009; 4(1):29-45. PMID: 20498689.
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    71. Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15; 22(22):3121-34. PMID: 19056892.
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    72. Marsden MD, Zack JA. Eradication of HIV: current challenges and new directions. J Antimicrob Chemother. 2009 Jan; 63(1):7-10. PMID: 18984648.
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    73. Marsden MD, Xu J, Hamer D, Zack JA. Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages. AIDS Res Hum Retroviruses. 2008 Nov; 24(11):1399-404. PMID: 19000022.
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    74. Burke B, Brown HJ, Marsden MD, Bristol G, Vatakis DN, Zack JA. Primary cell model for activation-inducible human immunodeficiency virus. J Virol. 2007 Jul; 81(14):7424-34. PMID: 17475639.
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    75. Marsden MD, Zack JA. Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo. J Virol. 2007 Jun; 81(11):6146-50. PMID: 17392373.
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    76. Hryniewicz A, Price DA, Moniuszko M, Boasso A, Edghill-Spano Y, West SM, Venzon D, Vaccari M, Tsai WP, Tryniszewska E, Nacsa J, Villinger F, Ansari AA, Trindade CJ, Morre M, Brooks D, Arlen P, Brown HJ, Kitchen CM, Zack JA, Douek DC, Shearer GM, Lewis MG, Koup RA, Franchini G. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. J Immunol. 2007 Mar 15; 178(6):3492-504. PMID: 17339444.
      View in: PubMed
    77. Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA. Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells. J Virol. 2007 Apr; 81(7):3574-82. PMID: 17229711.
      View in: PubMed
    78. Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman DD, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA. A plea for justice for jailed medical workers. Science. 2006 Nov 10; 314(5801):924-5. PMID: 17062652.
      View in: PubMed
    79. Bernstein HB, Plasterer MC, Schiff SE, Kitchen CM, Kitchen S, Zack JA. CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration. J Immunol. 2006 Sep 15; 177(6):3669-76. PMID: 16951326.
      View in: PubMed
    80. Galic Z, Kitchen SG, Kacena A, Subramanian A, Burke B, Cortado R, Zack JA. T lineage differentiation from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11742-7. PMID: 16844782.
      View in: PubMed
    81. Brown HJ, Zack JA. Animal models of HIV-1 latency and persistence. Curr Opin HIV AIDS. 2006 Mar; 1(2):103-7. PMID: 19372792.
      View in: PubMed
    82. Arlen PA, Brooks DG, Gao LY, Vatakis D, Brown HJ, Zack JA. Rapid expression of human immunodeficiency virus following activation of latently infected cells. J Virol. 2006 Feb; 80(3):1599-603. PMID: 16415036.
      View in: PubMed
    83. Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006 Jan 03; 103(1):111-6. PMID: 16373498.
      View in: PubMed
    84. Chang M, Brown HJ, Collado-Hidalgo A, Arevalo JM, Galic Z, Symensma TL, Tanaka L, Deng H, Zack JA, Sun R, Cole SW. beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J Virol. 2005 Nov; 79(21):13538-47. PMID: 16227274.
      View in: PubMed
    85. Widney DP, Breen EC, Boscardin WJ, Kitchen SG, Alcantar JM, Smith JB, Zack JA, Detels R, Martínez-Maza O. Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection. J Interferon Cytokine Res. 2005 Nov; 25(11):702-6. PMID: 16318584.
      View in: PubMed
    86. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005 Oct; 3(4):377-92. PMID: 16250884.
      View in: PubMed
    87. Kitchen SG, Whitmire JK, Jones NR, Galic Z, Kitchen CM, Ahmed R, Zack JA. The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3794-9. PMID: 15731353.
      View in: PubMed
    88. Brown HJ, McBride WH, Zack JA, Sun R. Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus. Antivir Ther. 2005; 10(6):745-51. PMID: 16218174.
      View in: PubMed
    89. Cole SW, Yan W, Galic Z, Arevalo J, Zack JA. Expression-based monitoring of transcription factor activity: the TELiS database. Bioinformatics. 2005 Mar; 21(6):803-10. PMID: 15374858.
      View in: PubMed
    90. Kitchen SG, Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA. CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8727-32. PMID: 15173593.
      View in: PubMed
    91. Chen H, Zha J, Gowans RE, Camargo P, Nishitani J, McQuirter JL, Cole SW, Zack JA, Liu X. Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor. AIDS Res Hum Retroviruses. 2004 May; 20(5):513-9. PMID: 15186526.
      View in: PubMed
    92. Richlin VA, Arevalo JM, Zack JA, Cole SW. Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution. Brain Behav Immun. 2004 May; 18(3):231-7. PMID: 15050650.
      View in: PubMed
    93. Amado RG, Mitsuyasu RT, Rosenblatt JD, Ngok FK, Bakker A, Cole S, Chorn N, Lin LS, Bristol G, Boyd MP, MacPherson JL, Fanning GC, Todd AV, Ely JA, Zack JA, Symonds GP. Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients. Hum Gene Ther. 2004 Mar; 15(3):251-62. PMID: 15018734.
      View in: PubMed
    94. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science. 2004 Jan 16; 303(5656):316. PMID: 14726576.
      View in: PubMed
    95. Ali A, Lubong R, Ng H, Brooks DG, Zack JA, Yang OO. Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol. 2004 Jan; 78(2):561-7. PMID: 14694087.
      View in: PubMed
    96. Moore JP, Kitchen SG, Pugach P, Zack JA. The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 2004 Jan; 20(1):111-26. PMID: 15000703.
      View in: PubMed
    97. Cole SW, Kemeny ME, Fahey JL, Zack JA, Naliboff BD. Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system. Biol Psychiatry. 2003 Dec 15; 54(12):1444-56. PMID: 14675810.
      View in: PubMed
    98. Brooks DG, Arlen PA, Gao L, Kitchen CM, Zack JA. Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12955-60. PMID: 14569007.
      View in: PubMed
    99. Cole SW, Galic Z, Zack JA. Controlling false-negative errors in microarray differential expression analysis: a PRIM approach. Bioinformatics. 2003 Sep 22; 19(14):1808-16. PMID: 14512352.
      View in: PubMed
    100. Brooks DG, Hamer DH, Arlen PA, Gao L, Bristol G, Kitchen CM, Berger EA, Zack JA. Molecular characterization, reactivation, and depletion of latent HIV. Immunity. 2003 Sep; 19(3):413-23. PMID: 14499116.
      View in: PubMed
    101. Liu X, Zha J, Nishitani J, Chen H, Zack JA. HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcohol. Virology. 2003 Mar 01; 307(1):37-44. PMID: 12667812.
      View in: PubMed
    102. Liu X, Zha J, Chen H, Nishitani J, Camargo P, Cole SW, Zack JA. Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes. J Virol. 2003 Mar; 77(6):3470-6. PMID: 12610122.
      View in: PubMed
    103. Koka PS, Brooks DG, Razai A, Kitchen CM, Zack JA. HIV type 1 infection alters cytokine mRNA expression in thymus. AIDS Res Hum Retroviruses. 2003 Jan 01; 19(1):1-12. PMID: 12581511.
      View in: PubMed
    104. Scripture-Adams DD, Brooks DG, Korin YD, Zack JA. Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J Virol. 2002 Dec; 76(24):13077-82. PMID: 12438635.
      View in: PubMed
    105. Korin YD, Brooks DG, Brown S, Korotzer A, Zack JA. Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol. 2002 Aug; 76(16):8118-23. PMID: 12134017.
      View in: PubMed
    106. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI. Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1813-8. PMID: 11854483.
      View in: PubMed
    107. Roth MD, Tashkin DP, Choi R, Jamieson BD, Zack JA, Baldwin GC. Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes. J Infect Dis. 2002 Mar 01; 185(5):701-5. PMID: 11865430.
      View in: PubMed
    108. Brooks DG, Zack JA. Effect of latent human immunodeficiency virus infection on cell surface phenotype. J Virol. 2002 Feb; 76(4):1673-81. PMID: 11799162.
      View in: PubMed
    109. Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA. Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor. Blood. 2002 Jan 01; 99(1):207-12. PMID: 11756173.
      View in: PubMed