Jerome A Zack

Title(s)Department Chair, MIMG
SchoolMedicine
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    Other Positions
    Title(s)Professor, Medicine

    Title(s)Professor, MIMG


    Collapse Biography 
    Collapse Education and Training
    UC Irvine, Irvine CABS1976Biology
    Cal State Long Beach, Long Beach CAMS1980Med Microbiology
    UT Health Science Center, Dallas TxPhD1987Immunology
    Collapse Awards and Honors
    Pediatric AIDS Foundation1996  - 2001Elizabeth Glazer Scientist Award
    NIH/NIAID1998NIH Merit Award
    Ohio State Univ2000Distinguished Research Career Award
    CSULB College of Natural Sciences and Mathematics2011Distinguished Alumnus

    Collapse Overview 
    Collapse Overview
    Jerome Zack, Ph.D., holds the M. Philip Davis Chair in Microbiology and Immunology. The Zack laboratory at UCLA is exploring ways to purge HIV reservoirs to effect either a cure or “functional cure” (long term remission) of HIV disease. It is long lived latent reservoirs that mandate that HIV infected individuals remain on antiretroviral therapy, because upon cessation of therapy, latent reservoirs rekindle virus replication and disease progression. The Zack laboratory is exploring “kick and kill” and immune system engineering to accomplish their goals.

    The kick and kill approach involves activation of infected cells to allow visualization of viral proteins, while the individual is on therapy to prevent spread of virus. Subsequently an anti-viral targeting approach is added, to kill the previously latently infected cell, which is now expressing viral proteins. Targeting approaches being pursued include cell-based effectors such as engineered CTL or NK cells. A recent study along these lines showed that a PKC modulator (kick) coupled with NK cells as the “kill” component, could decrease HIV reservoirs in a humanized mouse model.

    The genetic engineering approach involves introduction of anti-HIV chimeric antigen receptors (CARs) into human hematopoietic progenitor cells. These cells then develop into effector cells in vivo (T and NK cells), which can now target HIV infected cells. This approach has shown some efficacy in humanized mice and non-human primates.

    Much of Dr. Zack’s work involves the use of humanized mice, a tool which can be extended to other viral systems.

    Collapse Research 
    Collapse Research Activities and Funding
    Natural killer cell engineering to target the HIV reservoir
    NIH R01AI161803Apr 1, 2021 - Mar 31, 2026
    Role: Principal Investigator
    Defining Factors Controlling HIV Rebound
    NIH P01AI131294Aug 10, 2017 - Jul 31, 2022
    Role: Principal Investigator
    HIV Latency Reversal Through Novel, Potent PKC Modulators
    NIH R56AI124743Jul 1, 2016 - Jul 31, 2022
    Role: Principal Investigator
    HIV latency reversal through novel, potent PKC modulators
    NIH R01AI124743Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    HIV Infection of Hematopoietic Stem/Progenitor Cells (HSPC) in Bone Marrow
    NIH R01AI103385Jul 23, 2012 - Jun 30, 2014
    Role: Principal Investigator
    Control of Multineage Human ESC Differentiation
    NIH P01GM081621Aug 1, 2008 - Jul 31, 2014
    Role: Principal Investigator
    Targeting HIV Reservoirs in vitro and in vivo
    NIH R01AI070010Mar 1, 2006 - Jul 31, 2016
    Role: Principal Investigator
    Thymic Function and Immune Reconstitution for AIDS
    NIH R21AI061660Jan 15, 2006 - Dec 31, 2007
    Role: Principal Investigator
    Palm Springs Symposia on HIV/AIDS
    NIH R13AI068368Jan 1, 2006 - Jun 30, 2022
    Role: Principal Investigator
    CD4 EXPRESSION ON CD8+ CELLS
    NIH R01AI048392Jan 1, 2001 - Dec 31, 2005
    Role: Principal Investigator
    CYTOKINE THERAPY FOR HIV INFECTION IN VIVO
    NIH R01HL055205Sep 30, 1995 - Jul 31, 1999
    Role: Principal Investigator
    In Vivo Pathogenesis of HIV-1
    NIH R37AI036059Sep 1, 1994 - May 31, 2008
    Role: Principal Investigator
    IN VIVO PATHOGENESIS OF HIV-1
    NIH R01AI036059Sep 1, 1994 - May 31, 1998
    Role: Principal Investigator
    Immune Reconstitution Following HIV Infection
    NIH R01AI036554Aug 1, 1994 - Nov 30, 2007
    Role: Principal Investigator
    HIV-1 REVERSE TRANSCRIPTION IN QUIESCENT LYMPHOCYTES
    NIH R29AI033259Jan 1, 1993 - Dec 31, 1997
    Role: Principal Investigator
    HIV LATENCY/PERSISTENCE IN PRIMARY CELLS
    NIH F32AI008145Feb 28, 1989 - Feb 29, 1992
    Role: Principal Investigator
    UCLA Center for AIDS Research (CFAR)
    NIH P30AI028697Feb 29, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Defining the Effects of PKC Modulator HIV Latency-Reversing Agents on Natural Killer Cells. Pathog Immun. 2024; 9(1):108-137. Dimapasoc M, Moran JA, Cole SW, Ranjan A, Hourani R, Kim JT, Wender PA, Marsden MD, Zack JA. PMID: 38765786; PMCID: PMC11101012.
      View in: PubMed   Mentions:
    2. Current Advances in Humanized Mouse Models for Studying NK Cells and HIV Infection. Microorganisms. 2023 Aug 02; 11(8). Kim JT, Bresson-Tan G, Zack JA. PMID: 37630544; PMCID: PMC10458594.
      View in: PubMed   Mentions:
    3. Secreted factors induced by PKC modulators do not indirectly cause HIV latency reversal. Virology. 2023 04; 581:8-14. Moran JA, Ranjan A, Hourani R, Kim JT, Wender PA, Zack JA, Marsden MD. PMID: 36842270; PMCID: PMC10103183.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. A humanized mouse model to study NK cell biology during HIV infection. J Clin Invest. 2022 12 15; 132(24). Kim JT, Zack JA. PMID: 36519544; PMCID: PMC9753985.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Latency reversal plus natural killer cells diminish HIV reservoir in vivo. Nat Commun. 2022 01 10; 13(1):121. Kim JT, Zhang TH, Carmona C, Lee B, Seet CS, Kostelny M, Shah N, Chen H, Farrell K, Soliman MSA, Dimapasoc M, Sinani M, Blanco KYR, Bojorquez D, Jiang H, Shi Y, Du Y, Komarova NL, Wodarz D, Wender PA, Marsden MD, Sun R, Zack JA. PMID: 35013215; PMCID: PMC8748509.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    6. Correction: Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 Aug; 17(8):e1009895. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 34460861; PMCID: PMC8405002.
      View in: PubMed   Mentions: 1     Fields:    
    7. Robust CAR-T memory formation and function via hematopoietic stem cell delivery. PLoS Pathog. 2021 04; 17(4):e1009404. Zhen A, Carrillo MA, Mu W, Rezek V, Martin H, Hamid P, Chen ISY, Yang OO, Zack JA, Kitchen SG. PMID: 33793675; PMCID: PMC8016106.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    8. Stem cell-derived CAR T cells traffic to HIV reservoirs in macaques. JCI Insight. 2021 01 11; 6(1). Barber-Axthelm IM, Barber-Axthelm V, Sze KY, Zhen A, Suryawanshi GW, Chen IS, Zack JA, Kitchen SG, Kiem HP, Peterson CW. PMID: 33427210; PMCID: PMC7821595.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    9. Tracking HIV Rebound following Latency Reversal Using Barcoded HIV. Cell Rep Med. 2020 12 22; 1(9):100162. Marsden MD, Zhang TH, Du Y, Dimapasoc M, Soliman MSA, Wu X, Kim JT, Shimizu A, Schrier A, Wender PA, Sun R, Zack JA. PMID: 33377133; PMCID: PMC7762775.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo. Cell Rep Med. 2020 06 23; 1(3):100037. Pache L, Marsden MD, Teriete P, Portillo AJ, Heimann D, Kim JT, Soliman MSA, Dimapasoc M, Carmona C, Celeridad M, Spivak AM, Planelles V, Cosford NDP, Zack JA, Chanda SK. PMID: 33205060; PMCID: PMC7659604.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    11. Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10688-10698. Sloane JL, Benner NL, Keenan KN, Zang X, Soliman MSA, Wu X, Dimapasoc M, Chun TW, Marsden MD, Zack JA, Wender PA. PMID: 32371485; PMCID: PMC7245087.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    12. Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy. Nat Commun. 2020 04 20; 11(1):1879. Hardman C, Ho S, Shimizu A, Luu-Nguyen Q, Sloane JL, Soliman MSA, Marsden MD, Zack JA, Wender PA. PMID: 32312992; PMCID: PMC7170889.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    13. Essential Role of Human T Cell Leukemia Virus Type 1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice. J Virol. 2019 10 01; 93(19). Galli V, Nixon CC, Strbo N, Artesi M, de Castro-Amarante MF, McKinnon K, Fujikawa D, Omsland M, Washington-Parks R, Romero L, Caruso B, Durkin K, Brown S, Karim B, Vaccari M, Jacobson S, Zack JA, Van den Broeke A, Pise-Masison C, Franchini G. PMID: 31315992; PMCID: PMC6744231.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 10 03; 25(4):542-557.e9. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. PMID: 31495780; PMCID: PMC7018522.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    15. Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells. J Virol. 2019 05 15; 93(10). Llewellyn GN, Seclén E, Wietgrefe S, Liu S, Chateau M, Pei H, Perkey K, Marsden MD, Hinkley SJ, Paschon DE, Holmes MC, Zack JA, Louie SG, Haase AT, Cannon PM. PMID: 30842333; PMCID: PMC6498059.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2019 Feb 12; 10(1):52. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. PMID: 30755264; PMCID: PMC6373121.
      View in: PubMed   Mentions:    Fields:    
    17. Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. Virology. 2018 07; 520:83-93. Marsden MD, Wu X, Navab SM, Loy BA, Schrier AJ, DeChristopher BA, Shimizu AJ, Hardman CT, Ho S, Ramirez CM, Wender PA, Zack JA. PMID: 29800728; PMCID: PMC6018613.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    18. Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2018 03; 14(3):e1006891. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. PMID: 29529058; PMCID: PMC5846784.
      View in: PubMed   Mentions: 5     Fields:    
    19. Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2017 12; 13(12):e1006753. Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. PMID: 29284044; PMCID: PMC5746250.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    20. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017 10 02; 8(1):217. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. PMID: 28969679; PMCID: PMC5625837.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    21. In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication. PLoS Pathog. 2017 Sep; 13(9):e1006575. Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA. PMID: 28934369; PMCID: PMC5608406.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    22. Humanized Mouse Models for Human Immunodeficiency Virus Infection. Annu Rev Virol. 2017 09 29; 4(1):393-412. Marsden MD, Zack JA. PMID: 28746819; PMCID: PMC6542458.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    23. New approaches for the enhancement of chimeric antigen receptors for the treatment of HIV. Transl Res. 2017 09; 187:83-92. Carrillo MA, Zhen A, Zack JA, Kitchen SG. PMID: 28755872.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    24. Engineering HIV-Specific Immunity with Chimeric Antigen Receptors. AIDS Patient Care STDS. 2016 12; 30(12):556-561. Kitchen SG, Zack JA. PMID: 27905838; PMCID: PMC5144863.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy. Stem Cells Dev. 2016 12 15; 25(24):1863-1873. Smith DJ, Lin LJ, Moon H, Pham AT, Wang X, Liu S, Ji S, Rezek V, Shimizu S, Ruiz M, Lam J, Janzen DM, Memarzadeh S, Kohn DB, Zack JA, Kitchen SG, An DS, Yang L. PMID: 27608727; PMCID: PMC5165681.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    26. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, International AIDS Society Towards a Cure Working Group, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. PMID: 27400264; PMCID: PMC5322797.
      View in: PubMed   Mentions: 260     Fields:    Translation:Humans
    27. HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies. J Virol. 2016 08 01; 90(15):6999-7006. Ali A, Kitchen SG, Chen ISY, Ng HL, Zack JA, Yang OO. PMID: 27226366; PMCID: PMC4944295.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    28. Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model. J Vis Exp. 2016 07 02; (113). Zhen A, Rezek V, Youn C, Rick J, Lam B, Chang N, Zack J, Kamata M, Kitchen S. PMID: 27404517; PMCID: PMC4993349.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016 06; 18(6):595-606. Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. PMID: 27183470; PMCID: PMC4981340.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    30. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell. 2016 Apr 07; 18(4):533-40. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. PMID: 26877224; PMCID: PMC4826286.
      View in: PubMed   Mentions: 205     Fields:    Translation:HumansAnimalsCells
    31. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):109-19. Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. PMID: 26670361; PMCID: PMC4761823.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    32. Disruption of Type I Interferon Induction by HIV Infection of T Cells. PLoS One. 2015; 10(9):e0137951. Sanchez DJ, Miranda D, Marsden MD, Dizon TM, Bontemps JR, Davila SJ, Del Mundo LE, Ha T, Senaati A, Zack JA, Cheng G. PMID: 26375588; PMCID: PMC4574156.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    33. Corrigendum: Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor. Sci Rep. 2015 Jul 13; 5:9798. Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN. PMID: 26166708; PMCID: PMC4499881.
      View in: PubMed   Mentions:    Fields:    
    34. Cocaine-mediated impact on HIV infection in humanized BLT mice. Sci Rep. 2015 Jun 18; 5:10010. Kim SG, Lowe EL, Dixit D, Youn CS, Kim IJ, Jung JB, Rovner R, Zack JA, Vatakis DN. PMID: 26084721; PMCID: PMC4471720.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells. Mol Ther. 2015 Aug; 23(8):1358-1367. Zhen A, Kamata M, Rezek V, Rick J, Levin B, Kasparian S, Chen IS, Yang OO, Zack JA, Kitchen SG. PMID: 26050990; PMCID: PMC4817874.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    36. Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging. J Clin Invest. 2015 May; 125(5):1815-26. McCracken MN, Vatakis DN, Dixit D, McLaughlin J, Zack JA, Witte ON. PMID: 25822024; PMCID: PMC4463193.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    37. Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs. Cell Stem Cell. 2015 Apr 02; 16(4):367-72. Menon T, Firth AL, Scripture-Adams DD, Galic Z, Qualls SJ, Gilmore WB, Ke E, Singer O, Anderson LS, Bornzin AR, Alexander IE, Zack JA, Verma IM. PMID: 25772073; PMCID: PMC4545662.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    38. Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Sci Rep. 2015 Mar 02; 5:8670. Nixon CC, Schwartz BH, Dixit D, Zack JA, Vatakis DN. PMID: 25728014; PMCID: PMC4345342.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. RNAi-Mediated CCR5 Knockdown Provides HIV-1 Resistance to Memory T Cells in Humanized BLT Mice. Mol Ther Nucleic Acids. 2015 Feb 17; 4:e227. Shimizu S, Ringpis GE, Marsden MD, Cortado RV, Wilhalme HM, Elashoff D, Zack JA, Chen IS, An DS. PMID: 25689223; PMCID: PMC4345313.
      View in: PubMed   Mentions: 20  
    40. Double trouble: HIV latency and CTL escape. Cell Host Microbe. 2015 Feb 11; 17(2):141-2. Marsden MD, Zack JA. PMID: 25674977; PMCID: PMC4375954.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    41. Studies of retroviral infection in humanized mice. Virology. 2015 May; 479-480:297-309. Marsden MD, Zack JA. PMID: 25680625; PMCID: PMC4424058.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    42. Experimental Approaches for Eliminating Latent HIV. For Immunopathol Dis Therap. 2015; 6(1-2):91-99. Marsden MD, Zack JA. PMID: 28191361; PMCID: PMC5302864.
      View in: PubMed   Mentions: 12  
    43. Neutralizing the HIV reservoir. Cell. 2014 Aug 28; 158(5):971-972. Marsden MD, Zack JA. PMID: 25171398; PMCID: PMC4182933.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Bioengineered vaults: self-assembling protein shell-lipophilic core nanoparticles for drug delivery. ACS Nano. 2014 Aug 26; 8(8):7723-32. Buehler DC, Marsden MD, Shen S, Toso DB, Wu X, Loo JA, Zhou ZH, Kickhoefer VA, Wender PA, Zack JA, Rome LH. PMID: 25061969; PMCID: PMC4148163.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    45. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection. J Virol. 2014 Sep 01; 88(17):9934-46. Zhen A, Krutzik SR, Levin BR, Kasparian S, Zack JA, Kitchen SG. PMID: 24942581; PMCID: PMC4136363.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    46. Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res. 2014 May 01; 20(9):2457-65. Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A. PMID: 24634374; PMCID: PMC4070853.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    47. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status. Stem Cell Res Ther. 2013 Jul 26; 4(4):87. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. PMID: 23890092; PMCID: PMC3854769.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    48. HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice. Blood. 2013 Sep 26; 122(13):2195-204. Nixon CC, Vatakis DN, Reichelderfer SN, Dixit D, Kim SG, Uittenbogaart CH, Zack JA. PMID: 23886835; PMCID: PMC3785119.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    49. Cocaine exposure enhances permissiveness of quiescent T cells to HIV infection. J Leukoc Biol. 2013 Oct; 94(4):835-43. Kim SG, Jung JB, Dixit D, Rovner R, Zack JA, Baldwin GC, Vatakis DN. PMID: 23817564; PMCID: PMC3774841.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    50. Highly potent, synthetically accessible prostratin analogs induce latent HIV expression in vitro and ex vivo. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):11698-703. Beans EJ, Fournogerakis D, Gauntlett C, Heumann LV, Kramer R, Marsden MD, Murray D, Chun TW, Zack JA, Wender PA. PMID: 23812750; PMCID: PMC3718093.
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    51. HIV/AIDS eradication. Bioorg Med Chem Lett. 2013 Jul 15; 23(14):4003-10. Marsden MD, Zack JA. PMID: 23735743; PMCID: PMC3714230.
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    52. HIV restriction in quiescent CD4⁺ T cells. Retrovirology. 2013 Apr 04; 10:37. Zack JA, Kim SG, Vatakis DN. PMID: 23557201; PMCID: PMC3626626.
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    53. Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression. Mol Ther. 2013 May; 21(5):1055-63. Vatakis DN, Arumugam B, Kim SG, Bristol G, Yang O, Zack JA. PMID: 23481324; PMCID: PMC3666627.
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    54. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity. 2013 Jan 24; 38(1):92-105. Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G. PMID: 23273844; PMCID: PMC3698975.
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    55. Using the BLT humanized mouse as a stem cell based gene therapy tumor model. J Vis Exp. 2012 Dec 18; (70):e4181. Vatakis DN, Bristol GC, Kim SG, Levin B, Liu W, Radu CG, Kitchen SG, Zack JA. PMID: 23271478; PMCID: PMC3576416.
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    56. Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens. Antivir Ther. 2012; 17(7):1375-9. Marsden MD, Krogstad PA, Zack JA. PMID: 22820096.
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    57. Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro. Nat Chem. 2012 Sep; 4(9):705-10. DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA. PMID: 22914190; PMCID: PMC3428736.
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    58. In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells. PLoS Pathog. 2012; 8(4):e1002649. Kitchen SG, Levin BR, Bristol G, Rezek V, Kim S, Aguilera-Sandoval C, Balamurugan A, Yang OO, Zack JA. PMID: 22511873; PMCID: PMC3325196.
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    59. From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols. Stem Cells Transl Med. 2012 Jan; 1(1):36-43. Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE. PMID: 23197638; PMCID: PMC3727693.
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    60. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):E1408-16. Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA. PMID: 22123951; PMCID: PMC3251070.
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    61. HIV latency in the humanized BLT mouse. J Virol. 2012 Jan; 86(1):339-47. Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA. PMID: 22072769; PMCID: PMC3255908.
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    62. Genome-wide binding map of the HIV-1 Tat protein to the human genome. PLoS One. 2011; 6(11):e26894. Marban C, Su T, Ferrari R, Li B, Vatakis D, Pellegrini M, Zack JA, Rohr O, Kurdistani SK. PMID: 22073215; PMCID: PMC3208564.
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    63. HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes. Virology. 2011 Sep 01; 417(2):394-9. Marsden MD, Burke BP, Zack JA. PMID: 21777932; PMCID: PMC3163716.
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    64. Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt. Stem Cells Int. 2011; 2011:393698. Mitsuyasu RT, Zack JA, Macpherson JL, Symonds GP. PMID: 21716651; PMCID: PMC3116533.
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    65. Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages. Antimicrob Agents Chemother. 2011 Aug; 55(8):3696-702. Marsden MD, Avancena P, Kitchen CM, Hubbard T, Zack JA. PMID: 21628534; PMCID: PMC3147632.
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    66. Activation of latent HIV using drug-loaded nanoparticles. PLoS One. 2011 Apr 05; 6(4):e18270. Kovochich M, Marsden MD, Zack JA. PMID: 21483687; PMCID: PMC3071729.
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    67. Stem cell-based approaches to treating HIV infection. Curr Opin HIV AIDS. 2011 Jan; 6(1):68-73. Kitchen SG, Zack JA. PMID: 21242896; PMCID: PMC3267541.
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    68. Quiescent T cells and HIV: an unresolved relationship. Immunol Res. 2010 Dec; 48(1-3):110-21. Vatakis DN, Nixon CC, Zack JA. PMID: 20725862; PMCID: PMC3824961.
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    69. Female human iPSCs retain an inactive X chromosome. Cell Stem Cell. 2010 Sep 03; 7(3):329-42. Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. PMID: 20727844; PMCID: PMC2935700.
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    70. CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes. PLoS One. 2010 Jul 06; 5(7):e11448. Epeldegui M, Thapa DR, De la Cruz J, Kitchen S, Zack JA, Martínez-Maza O. PMID: 20625427; PMCID: PMC2897846.
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    71. Gene expression and transcription factor profiling reveal inhibition of transcription factor cAMP-response element-binding protein by gamma-herpesvirus replication and transcription activator. J Biol Chem. 2010 Aug 13; 285(33):25139-53. Brown HJ, Peng L, Harada JN, Walker JR, Cole S, Lin SF, Zack JA, Chanda SK, Sun R. PMID: 20516076; PMCID: PMC2919076.
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    72. Differential expression and interaction of host factors augment HIV-1 gene expression in neonatal mononuclear cells. Virology. 2010 Apr 25; 400(1):32-43. Sundaravaradan V, Mehta R, Harris DT, Zack JA, Ahmad N. PMID: 20138641.
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    73. Establishment and maintenance of HIV latency: model systems and opportunities for intervention. Future Virol. 2010 Jan 01; 5(1):97-109. Marsden MD, Zack JA. PMID: 21318097; PMCID: PMC3037592.
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    74. A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model. Blood. 2010 Feb 25; 115(8):1534-44. Shimizu S, Hong P, Arumugam B, Pokomo L, Boyer J, Koizumi N, Kittipongdaja P, Chen A, Bristol G, Galic Z, Zack JA, Yang O, Chen IS, Lee B, An DS. PMID: 20018916; PMCID: PMC2830759.
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    75. Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice. PLoS One. 2009 Dec 07; 4(12):e8208. Kitchen SG, Bennett M, Galic Z, Kim J, Xu Q, Young A, Lieberman A, Joseph A, Goldstein H, Ng H, Yang O, Zack JA. PMID: 19997617; PMCID: PMC2785433.
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    76. Human immunodeficiency virus integration efficiency and site selection in quiescent CD4+ T cells. J Virol. 2009 Jun; 83(12):6222-33. Vatakis DN, Kim S, Kim N, Chow SA, Zack JA. PMID: 19369341; PMCID: PMC2687367.
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    77. CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function. Virology. 2009 Apr 25; 387(1):59-66. Bernstein HB, Wang G, Plasterer MC, Zack JA, Ramasastry P, Mumenthaler SM, Kitchen CM. PMID: 19251297; PMCID: PMC2667870.
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    78. Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells. Nat Med. 2009 Mar; 15(3):285-92. Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, Bloch M, Lalezari J, Becker S, Thornton L, Akil B, Khanlou H, Finlayson R, McFarlane R, Smith DE, Garsia R, Ma D, Law M, Murray JM, von Kalle C, Ely JA, Patino SM, Knop AE, Wong P, Todd AV, Haughton M, Fuery C, Macpherson JL, Symonds GP, Evans LA, Pond SM, Cooper DA. PMID: 19219022; PMCID: PMC2768566.
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    79. Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents. J Virol. 2009 Apr; 83(7):3374-8. Vatakis DN, Nixon CC, Bristol G, Zack JA. PMID: 19129455; PMCID: PMC2655565.
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    80. Macrophage differentiation from embryoid bodies derived from human embryonic stem cells. J Stem Cells. 2009; 4(1):29-45. Subramanian A, Guo B, Marsden MD, Galic Z, Kitchen S, Kacena A, Brown HJ, Cheng G, Zack JA. PMID: 20498689; PMCID: PMC3476843.
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    81. A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells. 2009 Jan; 27(1):18-28. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark AT. PMID: 19224508; PMCID: PMC3194037.
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    82. Generation of T lineage cells from human embryonic stem cells in a feeder free system. Stem Cells. 2009 Jan; 27(1):100-7. Galic Z, Kitchen SG, Subramanian A, Bristol G, Marsden MD, Balamurugan A, Kacena A, Yang O, Zack JA. PMID: 18974209; PMCID: PMC2858464.
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    83. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15; 22(22):3121-34. Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. PMID: 19056892; PMCID: PMC2593606.
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    84. Eradication of HIV: current challenges and new directions. J Antimicrob Chemother. 2009 Jan; 63(1):7-10. Marsden MD, Zack JA. PMID: 18984648; PMCID: PMC2721701.
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    85. Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages. AIDS Res Hum Retroviruses. 2008 Nov; 24(11):1399-404. Marsden MD, Xu J, Hamer D, Zack JA. PMID: 19000022; PMCID: PMC2928488.
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    86. Primary cell model for activation-inducible human immunodeficiency virus. J Virol. 2007 Jul; 81(14):7424-34. Burke B, Brown HJ, Marsden MD, Bristol G, Vatakis DN, Zack JA. PMID: 17475639; PMCID: PMC1933352.
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    87. Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo. J Virol. 2007 Jun; 81(11):6146-50. Marsden MD, Zack JA. PMID: 17392373; PMCID: PMC1900283.
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    88. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. J Immunol. 2007 Mar 15; 178(6):3492-504. Hryniewicz A, Price DA, Moniuszko M, Boasso A, Edghill-Spano Y, West SM, Venzon D, Vaccari M, Tsai WP, Tryniszewska E, Nacsa J, Villinger F, Ansari AA, Trindade CJ, Morre M, Brooks D, Arlen P, Brown HJ, Kitchen CM, Zack JA, Douek DC, Shearer GM, Lewis MG, Koup RA, Franchini G. PMID: 17339444.
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    89. Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells. J Virol. 2007 Apr; 81(7):3574-82. Vatakis DN, Bristol G, Wilkinson TA, Chow SA, Zack JA. PMID: 17229711; PMCID: PMC1866069.
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    90. A plea for justice for jailed medical workers. Science. 2006 Nov 10; 314(5801):924-5. Ahuja SK, Aiuti F, Berkhout B, Biberfeld P, Burton DR, Colizzi V, Deeks SG, Desrosiers RC, Dierich MP, Doms RW, Emerman M, Gallo RC, Girard M, Greene WC, Hoxie JA, Hunter E, Klein G, Korber B, Kuritzkes DR, Lederman MM, Malim MH, Marx PA, McCune JM, McMichael A, Miller C, Miller V, Montagnier L, Montefiori DC, Moore JP, Nixon DF, Overbaugh J, Pauza CD, Richman DD, Saag MS, Sattentau Q, Schooley RT, Shattock R, Shaw GM, Stevenson M, Trkola A, Wainberg MA, Weiss RA, Wolinsky S, Zack JA. PMID: 17062652.
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    91. CD4 expression on activated NK cells: ligation of CD4 induces cytokine expression and cell migration. J Immunol. 2006 Sep 15; 177(6):3669-76. Bernstein HB, Plasterer MC, Schiff SE, Kitchen CM, Kitchen S, Zack JA. PMID: 16951326.
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    92. T lineage differentiation from human embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11742-7. Galic Z, Kitchen SG, Kacena A, Subramanian A, Burke B, Cortado R, Zack JA. PMID: 16844782; PMCID: PMC1544240.
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    93. Animal models of HIV-1 latency and persistence. Curr Opin HIV AIDS. 2006 Mar; 1(2):103-7. Brown HJ, Zack JA. PMID: 19372792.
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    94. Rapid expression of human immunodeficiency virus following activation of latently infected cells. J Virol. 2006 Feb; 80(3):1599-603. Arlen PA, Brooks DG, Gao LY, Vatakis D, Brown HJ, Zack JA. PMID: 16415036; PMCID: PMC1346949.
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    95. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006 Jan 03; 103(1):111-6. Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PMID: 16373498; PMCID: PMC1325011.
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    96. Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection. J Interferon Cytokine Res. 2005 Nov; 25(11):702-6. Widney DP, Breen EC, Boscardin WJ, Kitchen SG, Alcantar JM, Smith JB, Zack JA, Detels R, Martínez-Maza O. PMID: 16318584.
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    97. beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J Virol. 2005 Nov; 79(21):13538-47. Chang M, Brown HJ, Collado-Hidalgo A, Arevalo JM, Galic Z, Symensma TL, Tanaka L, Deng H, Zack JA, Sun R, Cole SW. PMID: 16227274; PMCID: PMC1262578.
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    98. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005 Oct; 3(4):377-92. Brooks DG, Cohen MD, Jamieson BD, Poon B, Kitchen SG, Chow SA, Chen IS, Zack JA, Koka PS. PMID: 16250884.
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    99. The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3794-9. Kitchen SG, Whitmire JK, Jones NR, Galic Z, Kitchen CM, Ahmed R, Zack JA. PMID: 15731353; PMCID: PMC553300.
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    100. Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus. Antivir Ther. 2005; 10(6):745-51. Brown HJ, McBride WH, Zack JA, Sun R. PMID: 16218174.
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    101. Expression-based monitoring of transcription factor activity: the TELiS database. Bioinformatics. 2005 Mar; 21(6):803-10. Cole SW, Yan W, Galic Z, Arevalo J, Zack JA. PMID: 15374858.
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    102. CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8727-32. Kitchen SG, Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA. PMID: 15173593; PMCID: PMC423263.
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    103. Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor. AIDS Res Hum Retroviruses. 2004 May; 20(5):513-9. Chen H, Zha J, Gowans RE, Camargo P, Nishitani J, McQuirter JL, Cole SW, Zack JA, Liu X. PMID: 15186526.
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    104. Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution. Brain Behav Immun. 2004 May; 18(3):231-7. Richlin VA, Arevalo JM, Zack JA, Cole SW. PMID: 15050650.
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    105. Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients. Hum Gene Ther. 2004 Mar; 15(3):251-62. Amado RG, Mitsuyasu RT, Rosenblatt JD, Ngok FK, Bakker A, Cole S, Chorn N, Lin LS, Bristol G, Boyd MP, MacPherson JL, Fanning GC, Todd AV, Ely JA, Zack JA, Symonds GP. PMID: 15018734.
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    106. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science. 2004 Jan 16; 303(5656):316. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. PMID: 14726576.
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    107. The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 2004 Jan; 20(1):111-26. Moore JP, Kitchen SG, Pugach P, Zack JA. PMID: 15000703.
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    108. Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol. 2004 Jan; 78(2):561-7. Ali A, Lubong R, Ng H, Brooks DG, Zack JA, Yang OO. PMID: 14694087; PMCID: PMC368806.
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    109. Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system. Biol Psychiatry. 2003 Dec 15; 54(12):1444-56. Cole SW, Kemeny ME, Fahey JL, Zack JA, Naliboff BD. PMID: 14675810.
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    110. Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12955-60. Brooks DG, Arlen PA, Gao L, Kitchen CM, Zack JA. PMID: 14569007; PMCID: PMC240726.
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    111. Controlling false-negative errors in microarray differential expression analysis: a PRIM approach. Bioinformatics. 2003 Sep 22; 19(14):1808-16. Cole SW, Galic Z, Zack JA. PMID: 14512352.
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    112. Molecular characterization, reactivation, and depletion of latent HIV. Immunity. 2003 Sep; 19(3):413-23. Brooks DG, Hamer DH, Arlen PA, Gao L, Bristol G, Kitchen CM, Berger EA, Zack JA. PMID: 14499116.
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    113. Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes. J Virol. 2003 Mar; 77(6):3470-6. Liu X, Zha J, Chen H, Nishitani J, Camargo P, Cole SW, Zack JA. PMID: 12610122; PMCID: PMC149546.
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    114. HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcohol. Virology. 2003 Mar 01; 307(1):37-44. Liu X, Zha J, Nishitani J, Chen H, Zack JA. PMID: 12667812.
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    115. HIV type 1 infection alters cytokine mRNA expression in thymus. AIDS Res Hum Retroviruses. 2003 Jan 01; 19(1):1-12. Koka PS, Brooks DG, Razai A, Kitchen CM, Zack JA. PMID: 12581511.
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    116. Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J Virol. 2002 Dec; 76(24):13077-82. Scripture-Adams DD, Brooks DG, Korin YD, Zack JA. PMID: 12438635; PMCID: PMC136703.
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    117. Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol. 2002 Aug; 76(16):8118-23. Korin YD, Brooks DG, Brown S, Korotzer A, Zack JA. PMID: 12134017; PMCID: PMC155166.
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    118. Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1813-8. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI. PMID: 11854483; PMCID: PMC122276.
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    119. Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes. J Infect Dis. 2002 Mar 01; 185(5):701-5. Roth MD, Tashkin DP, Choi R, Jamieson BD, Zack JA, Baldwin GC. PMID: 11865430.
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    120. Effect of latent human immunodeficiency virus infection on cell surface phenotype. J Virol. 2002 Feb; 76(4):1673-81. Brooks DG, Zack JA. PMID: 11799162; PMCID: PMC135922.
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    121. Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor. Blood. 2002 Jan 01; 99(1):207-12. Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA. PMID: 11756173.
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