Kathrin Plath

Title(s)Department Vice Chair, Biological Chemistry
SchoolMedicine
Emailkplath@mednet.ucla.edu
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    Title(s)Professor, Biological Chemistry


    Collapse Biography 
    Collapse Education and Training
    Humboldt University, Berlin, GermanyMS06/1994Biochemistry
    Humboldt University, Berlin, GermanyPhD06/1999Cell Biology
    Harvard Medical School, Boston06/2000Cell Biology
    UCSF, San Franzisco04/2003Epigenetics
    MIT/Whitehead Institute, Cambridge02/2006Stem Cell Biology
    Collapse Awards and Honors
    Humboldt University, Germany1989  - 1990Undergraduate Fellowship
    Max-Delbrück-Center, Berlin, Germany1995  - 1998Graduate Fellowship
    German Society of Biochemistry2000Byk-Gulden Graduate Thesis Award
    Germany2001Junior Scientist Award of the States Berlin and Brandenburg
    Life Sciences Research Foundation2001  - 2004Postdoctoral Fellowship
    Leukemia and Lymphoma Society2004  - 2007Special Postdoctoral Fellowship
    Kimmel Foundation2007Kimmel Foundation Scholar
    V Foundation2007V Foundation Scholar
    NIH2007Director’s New Innovator Award
    CIRM2008Young Investigator Award
    David Geffen School of Medicine, UCLA2009John H. Walsh Young Investigator Research Price
    ISSCR2011  - 2017Board of Directors
    HHMI2016Faculty Scholar Award
    Cell, Science, Stem Cell Reports, Embo Reports, etcEditorial Board

    Collapse Overview 
    Collapse Overview
    The Plath lab has made numerous ground-breaking contributions that have vast impacts on the scientific community. For example, the lab is leading the way in the discovery of mechanisms underlying X-chromosome inactivation by the long non-coding RNA Xist, from identifying how the RNA can target an entire chromosome to defining protein crowding as the mechanism of action by which few Xist molecules can silence the the 1000 genes along the entire X chromosome. The work of the Plath lab on Xist is showing how RNAs can build functional nuclear compartments. The Plath lab also pioneered the understanding of different modes on X-chromosome dosage compensation by XIST RNA in early human development and discovered an unexpected autosomal function for the RNA with implications for understanding the female bias of diseases. The Plath lab also uncovered key mechanisms underlying transcription factor-induced reprogramming of somatic cells to induced pluripotent stem cells that are providing a considerable impetus for understanding and rationally designing cell fate transition. Here we specifically focus on how cis-regulatory enhancer elements are selected and activated by transcription factors. We are also dissecting how genetic variation controls enhancer function.

    In addition to continuing the work on X-chromosome dosage compensation, lncRNA function, enhancers and gene regulation, the Plath lab is now also aiming to understand how nutrients that vary with diet can regulate stem cell states and cell fate decisions, particularly those during development, with the ultimate goal to define dietary alterations that enable more accurate models of differentiation in the culture dish or lead to new treatments of pregnancy complications and diseases. We are also using embryonic stem cells, induced pluripotent stem cells and new embryo models to understand the gene regulatory networks underlying cellular specification during development and pathophysiologies.

    Often, we develop new single cell genomics technologies and apply them to our diverse biological model systems. In collaboration with the Gomperts lab, we are, for instance, deciphering the difference between the healthy and disease lung at a mechanistic and omics level applying novel multi-comics approaches.
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic Screen in a Preclinical Model of Sarcoma Development Defines Drivers and Therapeutic Vulnerabilities. Clin Cancer Res. 2024 Nov 01; 30(21):4957-4973. Freeland J, Muñoz M, O'Donnell E, Langerman J, Darrow M, Bergonio J, Suarez-Navarro J, Thorpe S, Canter R, Randall RL, Plath K, Carraway KL, Witte ON, Graeber TG, Carr-Ascher JR. PMID: 39177582; PMCID: PMC11530313.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. A critical role for X-chromosome architecture in mammalian X-chromosome dosage compensation. Curr Opin Genet Dev. 2024 Aug; 87:102235. Dror I, Tan T, Plath K. PMID: 39053028; PMCID: PMC11317216.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Loss of cell junctional components and matrix alterations drive cell desquamation and fibrotic changes in Idiopathic Pulmonary Fibrosis. bioRxiv. 2024 Jun 22. Chandran RR, Vijayaraj P, Garcia-Milian R, King J, Castillo K, Chen L, Kwon Y, William S, Rickabaugh TM, Langerman J, Choi W, Sen C, Lever JEP, Li Q, Pavelkova N, Plosa EJ, Rowe SM, Plath K, Clair G, Gomperts BN. PMID: 38948715; PMCID: PMC11212876.
      View in: PubMed   Mentions:
    4. RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding. Chem Rev. 2024 Apr 24; 124(8):4734-4777. Zacco E, Broglia L, Kurihara M, Monti M, Gustincich S, Pastore A, Plath K, Nagakawa S, Cerase A, Sanchez de Groot N, Tartaglia GG. PMID: 38579177; PMCID: PMC11046439.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets. ACS Synth Biol. 2024 02 16; 13(2):498-508. Tang AA, Afasizheva A, Cano CT, Plath K, Black D, Franco E. PMID: 38295291.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. XIST directly regulates X-linked and autosomal genes in naive human pluripotent cells. Cell. 2024 01 04; 187(1):110-129.e31. Dror I, Chitiashvili T, Tan SYX, Cano CT, Sahakyan A, Markaki Y, Chronis C, Collier AJ, Deng W, Liang G, Sun Y, Afasizheva A, Miller J, Xiao W, Black DL, Ding F, Plath K. PMID: 38181737; PMCID: PMC10783549.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq. Nat Nanotechnol. 2024 Mar; 19(3):354-363. Udani S, Langerman J, Koo D, Baghdasarian S, Cheng B, Kang S, Soemardy C, de Rutte J, Plath K, Di Carlo D. PMID: 38082117; PMCID: PMC11452923.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    8. H3K36 methylation maintains cell identity by regulating opposing lineage programmes. Nat Cell Biol. 2023 Aug; 25(8):1121-1134. Hoetker MS, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong LP, Huebner AJ, Charlton J, Deng W, Haggerty C, Sadreyev RI, Meissner A, Michor F, Plath K, Hochedlinger K. PMID: 37460697; PMCID: PMC10896483.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    9. Nutrient regulation of development and cell fate decisions. Development. 2023 10 15; 150(20). Tu WB, Christofk HR, Plath K. PMID: 37260407; PMCID: PMC10281554.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. ZFP36-mediated mRNA decay regulates metabolism. Cell Rep. 2023 05 30; 42(5):112411. Cicchetto AC, Jacobson EC, Sunshine H, Wilde BR, Krall AS, Jarrett KE, Sedgeman L, Turner M, Plath K, Iruela-Arispe ML, de Aguiar Vallim TQ, Christofk HR. PMID: 37086408; PMCID: PMC10332406.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. Secretion encoded single-cell sequencing (SEC-seq) uncovers gene expression signatures associated with high VEGF-A secretion in mesenchymal stromal cells. bioRxiv. 2023 Jan 08. Udani S, Langerman J, Koo D, Baghdasarian S, Cheng B, Kang S, Soemardy C, de Rutte J, Plath K, Carlo DD. PMID: 36711480; PMCID: PMC9881958.
      View in: PubMed   Mentions:
    12. High-Field Asymmetric Waveform Ion Mobility Spectrometry Interface Enhances Parallel Reaction Monitoring on an Orbitrap Mass Spectrometer. Anal Chem. 2022 11 22; 94(46):15939-15947. Deng W, Sha J, Xue F, Jami-Alahmadi Y, Plath K, Wohlschlegel J. PMID: 36347042; PMCID: PMC9685594.
      View in: PubMed   Mentions:    Fields:    
    13. Oct4:Sox2 binding is essential for establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells. Genes Dev. 2022 10 01; 36(19-20):1079-1095. Lo JH, Edwards M, Langerman J, Sridharan R, Plath K, Smale ST. PMID: 36418052; PMCID: PMC9744233.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports. 2022 10 11; 17(10):2220-2238. Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. PMID: 36179695; PMCID: PMC9561534.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    15. A lifelong duty: how Xist maintains the inactive X chromosome. Curr Opin Genet Dev. 2022 08; 75:101927. Jacobson EC, Pandya-Jones A, Plath K. PMID: 35717799; PMCID: PMC9472561.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes. Stem Cell Reports. 2022 06 14; 17(6):1268-1278. Chitiashvili T, Hsu FM, Dror I, Plath K, Clark A. PMID: 35594860; PMCID: PMC9214056.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming. Sci Adv. 2022 03 25; 8(12):eabk0013. Collier AJ, Bendall A, Fabian C, Malcolm AA, Tilgner K, Semprich CI, Wojdyla K, Nisi PS, Kishore K, Roamio Franklin VN, Mirshekar-Syahkal B, D'Santos C, Plath K, Yusa K, Rugg-Gunn PJ. PMID: 35333572; PMCID: PMC8956265.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Transcriptional, Electrophysiological, and Metabolic Characterizations of hESC-Derived First and Second Heart Fields Demonstrate a Potential Role of TBX5 in Cardiomyocyte Maturation. Front Cell Dev Biol. 2021; 9:787684. Pezhouman A, Nguyen NB, Sercel AJ, Nguyen TL, Daraei A, Sabri S, Chapski DJ, Zheng M, Patananan AN, Ernst J, Plath K, Vondriska TM, Teitell MA, Ardehali R. PMID: 34988079; PMCID: PMC8722677.
      View in: PubMed   Mentions: 3  
    19. Xist nucleates local protein gradients to propagate silencing across the X chromosome. Cell. 2021 Dec 09; 184(25):6212. Markaki Y, Chong JG, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Sch?neberg J, Heard E, Guttman M, Chou T, Plath K. PMID: 34890555; PMCID: PMC8722464.
      View in: PubMed   Mentions: 9     Fields:    
    20. RNA promotes the formation of spatial compartments in the nucleus. Cell. 2021 11 11; 184(23):5775-5790.e30. Quinodoz SA, Jachowicz JW, Bhat P, Ollikainen N, Banerjee AK, Goronzy IN, Blanco MR, Chovanec P, Chow A, Markaki Y, Thai J, Plath K, Guttman M. PMID: 34739832; PMCID: PMC9115877.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    21. Xist nucleates local protein gradients to propagate silencing across the X chromosome. Cell. 2021 12 09; 184(25):6174-6192.e32. Markaki Y, Gan Chong J, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schöneberg J, Heard E, Guttman M, Chou T, Plath K. PMID: 34813726; PMCID: PMC8671326.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    22. Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis. Stem Cell Reports. 2021 10 12; 16(10):2548-2564. Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Huang J, Wei X, Samarasinghe RA, Polioudakis D, Mody I, Cobos I, Novitch BG, Geschwind DH, Plath K, Lowry WE. PMID: 34506726; PMCID: PMC8514853.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    23. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci. 2021 10; 24(10):1488-1500. Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. PMID: 34426698; PMCID: PMC9070733.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    24. Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development. Stem Cell Res. 2021 08; 55:102493. Hancock GV, Liu W, Peretz L, Chen D, Gell JJ, Collier AJ, Zamudio JR, Plath K, Clark AT. PMID: 34399163; PMCID: PMC8969886.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. The transcription factor code in iPSC reprogramming. Curr Opin Genet Dev. 2021 10; 70:89-96. Deng W, Jacobson EC, Collier AJ, Plath K. PMID: 34246082; PMCID: PMC9469655.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Nat Med. 2021 05; 27(5):806-814. Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. PMID: 33958799; PMCID: PMC9009537.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansCells
    27. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition. Nat Commun. 2021 03 25; 12(1):1876. Mullen PJ, Garcia G, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. PMID: 33767183; PMCID: PMC7994801.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    28. Carboxylate-Modified Magnetic Bead (CMMB)-Based Isopropanol Gradient Peptide Fractionation (CIF) Enables Rapid and Robust Off-Line Peptide Mixture Fractionation in Bottom-Up Proteomics. Mol Cell Proteomics. 2021; 20:100039. Deng W, Sha J, Plath K, Wohlschlegel JA. PMID: 33476790; PMCID: PMC7950212.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    29. Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment. Cell Stem Cell. 2021 04 01; 28(4):764-778.e4. Guo J, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E, DonorConnect, Plath K, Hotaling JM, Stukenborg JB, Clark AT, Cairns BR. PMID: 33453151; PMCID: PMC8026516.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    30. Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates. Cell Rep. 2020 12 29; 33(13):108562. Patananan AN, Sercel AJ, Wu TH, Ahsan FM, Torres A, Kennedy SAL, Vandiver A, Collier AJ, Mehrabi A, Van Lew J, Zakin L, Rodriguez N, Sixto M, Tadros W, Lazar A, Sieling PA, Nguyen TL, Dawson ER, Braas D, Golovato J, Cisneros L, Vaske C, Plath K, Rabizadeh S, Niazi KR, Chiou PY, Teitell MA. PMID: 33378680; PMCID: PMC7927156.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. Chromatin and Nuclear Architecture in Stem Cells. Stem Cell Reports. 2020 12 08; 15(6):1155-1157. Meshorer E, Plath K. PMID: 33296671; PMCID: PMC7724516.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    32. Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation. Nat Cell Biol. 2020 12; 22(12):1436-1446. Chitiashvili T, Dror I, Kim R, Hsu FM, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke-Layland K, Plath K, Clark A. PMID: 33257808; PMCID: PMC7717582.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    33. Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response. Cell Stem Cell. 2020 12 03; 27(6):869-875.e4. Purkayastha A, Sen C, Garcia G, Langerman J, Shia DW, Meneses LK, Vijayaraj P, Durra A, Koloff CR, Freund DR, Chi J, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. PMID: 33259798; PMCID: PMC7670932.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    34. Publisher Correction: A protein assembly mediates Xist localization and gene silencing. Nature. 2020 Oct; 586(7830):E30. Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Leon WRM, Damianov A, Chronis C, Papp B, Chen CK, McKee R, Wang XJ, Chau A, Sabri S, Leonhardt H, Zheng S, Guttman M, Black DL, Plath K. PMID: 33005055.
      View in: PubMed   Mentions: 2     Fields:    
    35. A protein assembly mediates Xist localization and gene silencing. Nature. 2020 11; 587(7832):145-151. Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Mancia Leon WR, Damianov A, Chronis C, Papp B, Chen CK, McKee R, Wang XJ, Chau A, Sabri S, Leonhardt H, Zheng S, Guttman M, Black DL, Plath K. PMID: 32908311; PMCID: PMC7644664.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    36. Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair response. bioRxiv. 2020 Jul 29. Purkayastha A, Sen C, Garcia G, Langerman J, Vijayaraj P, Shia DW, Meneses LK, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K, Arumugaswami V, Gomperts BN. PMID: 32766588; PMCID: PMC7402049.
      View in: PubMed   Mentions:
    37. A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. Cell Stem Cell. 2020 Jul 02; 27(1):181-185. Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD. PMID: 32619514; PMCID: PMC9012334.
      View in: PubMed   Mentions: 25     Fields:    
    38. A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. Cell Stem Cell. 2020 07 02; 27(1):158-176.e10. Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD. PMID: 32396864; PMCID: PMC7367475.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    39. Defining Transcriptional Signatures of Human Hair Follicle Cell States. J Invest Dermatol. 2020 04; 140(4):764-773.e4. Takahashi R, Grzenda A, Allison TF, Rawnsley J, Balin SJ, Sabri S, Plath K, Lowry WE. PMID: 31676413; PMCID: PMC7093259.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    40. A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation. Neuron. 2019 09 04; 103(5):785-801.e8. Polioudakis D, de la Torre-Ubieta L, Langerman J, Elkins AG, Shi X, Stein JL, Vuong CK, Nichterwitz S, Gevorgian M, Opland CK, Lu D, Connell W, Ruzzo EK, Lowe JK, Hadzic T, Hinz FI, Sabri S, Lowry WE, Gerstein MB, Plath K, Geschwind DH. PMID: 31303374; PMCID: PMC6831089.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansCells
    41. DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS). PLoS One. 2019; 14(4):e0214368. Bonora G, Rubbi L, Morselli M, Ma F, Chronis C, Plath K, Pellegrini M. PMID: 30946758; PMCID: PMC6448829.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    42. The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell. 2019 01 03; 24(1):138-152.e8. Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, Chen L, Wu G, Zhu Z, Yu Y, Yu L, Choudhary J, Nichols J, Parast MM, Greber B, Sahlén P, Plath K. PMID: 30609396; PMCID: PMC6486830.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    43. Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming. BMC Genomics. 2018 Dec 22; 19(1):956. Fu K, Chronis C, Soufi A, Bonora G, Edwards M, Smale ST, Zaret KS, Plath K, Pellegrini M. PMID: 30577748; PMCID: PMC6303873.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    44. Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods. Mol Cell. 2019 01 17; 73(2):250-263.e5. Sun F, Chronis C, Kronenberg M, Chen XF, Su T, Lay FD, Plath K, Kurdistani SK, Carey MF. PMID: 30527662; PMCID: PMC6338517.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    45. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nat Methods. 2018 09; 15(9):732-740. Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger K. PMID: 30127506; PMCID: PMC6127858.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    46. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. J Vis Exp. 2018 06 21; (136). Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA. PMID: 29985359; PMCID: PMC6101961.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    47. The Role of Xist in X-Chromosome Dosage Compensation. Trends Cell Biol. 2018 12; 28(12):999-1013. Sahakyan A, Yang Y, Plath K. PMID: 29910081; PMCID: PMC6249047.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    48. Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substate in Human Embryonic Stem Cells. Stem Cell Reports. 2018 06 05; 10(6):1895-1907. Allison TF, Smith AJH, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, Hackland J, Sabri S, Langerman J, Jones M, Plath K, Coca D, Barbaric I, Gokhale P, Andrews PW. PMID: 29779895; PMCID: PMC5993559.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    49. Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. Stem Cell Reports. 2018 05 08; 10(5):1453-1463. Ohashi M, Korsakova E, Allen D, Lee P, Fu K, Vargas BS, Cinkornpumin J, Salas C, Park JC, Germanguz I, Langerman J, Chronis C, Kuoy E, Tran S, Xiao X, Pellegrini M, Plath K, Lowry WE. PMID: 29742391; PMCID: PMC5995366.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    50. X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. Stem Cell Reports. 2018 05 08; 10(5):1537-1550. Pasque V, Karnik R, Chronis C, Petrella P, Langerman J, Bonora G, Song J, Vanheer L, Sadhu Dimashkie A, Meissner A, Plath K. PMID: 29681539; PMCID: PMC5995367.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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    121. Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry. Mol Cell Proteomics. 2006 Jan; 5(1):194-203. Chu F, Nusinow DA, Chalkley RJ, Plath K, Panning B, Burlingame AL. PMID: 16210244.
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    122. Developmental regulation of Suz 12 localization. Chromosoma. 2005 Aug; 114(3):183-92. de la Cruz CC, Fang J, Plath K, Worringer KA, Nusinow DA, Zhang Y, Panning B. PMID: 15986205.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    123. Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome. J Cell Biol. 2004 Dec 20; 167(6):1025-35. Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B. PMID: 15596546; PMCID: PMC2172612.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    124. Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum. Mol Biol Cell. 2004 Jan; 15(1):1-10. Plath K, Wilkinson BM, Stirling CJ, Rapoport TA. PMID: 14617809; PMCID: PMC307522.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    125. Role of histone H3 lysine 27 methylation in X inactivation. Science. 2003 Apr 04; 300(5616):131-5. Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y. PMID: 12649488.
      View in: PubMed   Mentions: 548     Fields:    Translation:HumansAnimalsCells
    126. Xist RNA and the mechanism of X chromosome inactivation. Annu Rev Genet. 2002; 36:233-78. Plath K, Mlynarczyk-Evans S, Nusinow DA, Panning B. PMID: 12429693.
      View in: PubMed   Mentions: 192     Fields:    Translation:AnimalsCells
    127. The structure of ribosome-channel complexes engaged in protein translocation. Mol Cell. 2000 Nov; 6(5):1219-32. Menetret JF, Neuhof A, Morgan DG, Plath K, Radermacher M, Rapoport TA, Akey CW. PMID: 11106759.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    128. Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum. J Cell Biol. 2000 Oct 02; 151(1):167-78. Plath K, Rapoport TA. PMID: 11018062; PMCID: PMC2189806.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    129. Posttranslational protein translocation across the membrane of the endoplasmic reticulum. Biol Chem. 1999 Oct; 380(10):1143-50. Rapoport TA, Matlack KE, Plath K, Misselwitz B, Staeck O. PMID: 10595576.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    130. BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane. Cell. 1999 May 28; 97(5):553-64. Matlack KE, Misselwitz B, Plath K, Rapoport TA. PMID: 10367885.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    131. Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. Cell. 1998 Sep 18; 94(6):795-807. Plath K, Mothes W, Wilkinson BM, Stirling CJ, Rapoport TA. PMID: 9753326.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    132. Protein transport by purified yeast Sec complex and Kar2p without membranes. Science. 1997 Aug 15; 277(5328):938-41. Matlack KE, Plath K, Misselwitz B, Rapoport TA. PMID: 9252322.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    133. Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation. Cell. 1996 Nov 15; 87(4):721-32. Hanein D, Matlack KE, Jungnickel B, Plath K, Kalies KU, Miller KR, Rapoport TA, Akey CW. PMID: 8929540.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    134. A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae. EMBO J. 1996 Apr 01; 15(7):1482-94. Finke K, Plath K, Panzner S, Prehn S, Rapoport TA, Hartmann E, Sommer T. PMID: 8612571; PMCID: PMC450055.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    135. Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. J Biol Chem. 1995 Nov 10; 270(45):27213-21. Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M. PMID: 7592979.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    136. Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro. Biochem Biophys Res Commun. 1994 Sep 15; 203(2):1188-94. Plath K, Engel K, Schwedersky G, Gaestel M. PMID: 8093038.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    137. The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett. 1993 Dec 20; 336(1):143-7. Engel K, Plath K, Gaestel M. PMID: 8262198.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
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