Istvan Mody

Title(s)Professor, Neurology
SchoolMedicine
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    Title(s)Professor, Physiology


    Collapse Overview 
    Collapse Overview
    Istvan Mody, Ph.D., holds the Tony Coelho Chair in Neurology.

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Neurotransmitter Action by Steroid Hormones in Females
    NIH RF1AG050474Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Targeting specific cortical microcircuit components to enhance functional recover
    NIH R21NS081438Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Identifying neurons and circuits critical for epileptogenesis
    NIH R01NS075429Jul 15, 2011 - May 31, 2015
    Role: Principal Investigator
    Structural and Functional Alterations of Interneurons in Models of Schizophrenia
    NIH R21MH092647May 10, 2011 - Apr 30, 2013
    Role: Principal Investigator
    Regulations of Neurotransmitter Action by Steroid Hormones in Females
    NIH R01MH076994Aug 1, 2007 - May 31, 2012
    Role: Principal Investigator
    Mechanisms/GHB/models/acute/chronic GBH intoxication.
    NIH R01DA014947Sep 30, 2001 - Jul 31, 2006
    Role: Principal Investigator
    Mechanisms for Neurological Dysfunction in NF1
    NIH R01NS038480Sep 4, 1998 - Dec 31, 2008
    Role: Co-Principal Investigator
    ALTERED EXCITABILITY OF EPILEPTIC NEURONS
    NIH R01NS036142Apr 1, 1997 - Mar 31, 2001
    Role: Principal Investigator
    Endogenous GABAergic Activity in the Mammalian Brain
    NIH R01NS030549May 1, 1992 - May 31, 2020
    Role: Principal Investigator
    Endogenous GABAergic Activity
    NIH R37NS030549May 1, 1992 - Feb 28, 2009
    Role: Principal Investigator
    Neuronal Calcium Homeostasis and Synaptic Function
    NIH R01NS027528Aug 1, 1990 - Mar 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice. Proc Natl Acad Sci U S A. 2024 Aug 13; 121(33):e2400420121. Wei X, Campagna JJ, Jagodzinska B, Wi D, Cohn W, Lee JT, Zhu C, Huang CS, Molnár L, Houser CR, John V, Mody I. PMID: 39106304; PMCID: PMC11331084.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices. Nat Commun. 2024 Jun 26; 15(1):5402. Berki P, Cserép C, Környei Z, Pósfai B, Szabadits E, Domonkos A, Kellermayer A, Nyerges M, Wei X, Mody I, Kunihiko A, Beck H, Kaikai H, Ya W, Lénárt N, Wu Z, Jing M, Li Y, Gulyás AI, Dénes Á. PMID: 38926390; PMCID: PMC11208608.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. A therapeutic small molecule lead enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice. bioRxiv. 2023 Dec 06. Wei X, Campagna JJ, Jagodzinska B, Wi D, Cohn W, Lee J, Zhu C, Huang CS, Molnár L, Houser CR, John V, Mody I. PMID: 38106006; PMCID: PMC10723366.
      View in: PubMed   Mentions:
    4. Motor Activity-Induced White Matter Repair in White Matter Stroke. J Neurosci. 2023 11 29; 43(48):8126-8139. Marin MA, Gleichman AJ, Wei X, Whittaker DS, Mody I, Colwell CS, Carmichael ST. PMID: 37821228; PMCID: PMC10697402.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Capturing the power of seizures: an empirical mode decomposition analysis of epileptic activity in the mouse hippocampus. Front Mol Neurosci. 2023; 16:1121479. Molnár L, Ferando I, Liu B, Mokhtar P, Domokos J, Mody I. PMID: 37256078; PMCID: PMC10225690.
      View in: PubMed   Mentions: 1  
    6. Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings. Front Cell Neurosci. 2022; 16:1039957. Alich TC, Röderer P, Szalontai B, Golcuk K, Tariq S, Peitz M, Brüstle O, Mody I. PMID: 36733665; PMCID: PMC9887032.
      View in: PubMed   Mentions: 4  
    7. Virally-induced expression of GABAA receptor δ subunits following their pathological loss reveals their role in regulating GABAA receptor assembly. Prog Neurobiol. 2022 11; 218:102337. Sun Y, Peng Z, Wei X, Zhang N, Huang CS, Wallner M, Mody I, Houser CR. PMID: 35934131; PMCID: PMC10091858.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Altered brain rhythms and behaviour in the accelerated ovarian failure mouse model of human menopause. Brain Commun. 2022; 4(4):fcac166. Vrontou S, Bédécarrats A, Wei X, Ayodeji M, Brassai A, Molnár L, Mody I. PMID: 35794872; PMCID: PMC9253886.
      View in: PubMed   Mentions: 3  
    9. Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis. Stem Cell Reports. 2021 10 12; 16(10):2548-2564. Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Huang J, Wei X, Samarasinghe RA, Polioudakis D, Mody I, Cobos I, Novitch BG, Geschwind DH, Plath K, Lowry WE. PMID: 34506726; PMCID: PMC8514853.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Identification of neural oscillations and epileptiform changes in human brain organoids. Nat Neurosci. 2021 10; 24(10):1488-1500. Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I, Novitch BG. PMID: 34426698; PMCID: PMC9070733.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    11. A dark quencher genetically encodable voltage indicator (dqGEVI) exhibits high fidelity and speed. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). Alich TC, Pabst M, Pothmann L, Szalontai B, Faas GC, Mody I. PMID: 33531364; PMCID: PMC8017929.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Mossy Cells in the Dorsal and Ventral Dentate Gyrus Differ in Their Patterns of Axonal Projections. J Neurosci. 2021 02 03; 41(5):991-1004. Houser CR, Peng Z, Wei X, Huang CS, Mody I. PMID: 33268544; PMCID: PMC7880284.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    13. GABAAR Modulator for Postpartum Depression. Cell. 2019 01 10; 176(1-2):1. Mody I. PMID: 30633900.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    14. Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons. Neuropharmacology. 2019 04; 148:11-20. Wei X, Nishi T, Kondou S, Kimura H, Mody I. PMID: 30594698; PMCID: PMC6424632.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    15. Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease. eNeuro. 2018 Jul-Aug; 5(4). Chen L, Saito T, Saido TC, Mody I. PMID: 30105300; PMCID: PMC6088364.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    16. Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain. J Vis Exp. 2018 05 07; (135). Octeau JC, Faas G, Mody I, Khakh BS. PMID: 29781998; PMCID: PMC6101127.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    17. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018 03 07; 97(5):1032-1048.e5. Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW. PMID: 29518357; PMCID: PMC5927822.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    18. The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation. Neural Plast. 2017; 2017:5196958. Chen X, Wang Y, Xu F, Wei X, Zhang J, Wang C, Wei H, Xu S, Yan P, Zhou W, Mody I, Xu X, Wang Q. PMID: 28255459; PMCID: PMC5307006.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. Diminished KCC2 confounds synapse specificity of LTP during senescence. Nat Neurosci. 2016 09; 19(9):1197-200. Ferando I, Faas GC, Mody I. PMID: 27500406; PMCID: PMC5003660.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    20. Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus. Neuron. 2016 05 18; 90(4):853-65. Pabst M, Braganza O, Dannenberg H, Hu W, Pothmann L, Rosen J, Mody I, van Loo K, Deisseroth K, Becker AJ, Schoch S, Beck H. PMID: 27161528.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    21. Behavioral Deficits in Juveniles Mediated by Maternal Stress Hormones in Mice. Neural Plast. 2016; 2016:2762518. Maguire J, Mody I. PMID: 26819762; PMCID: PMC4706939.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    22. Evolution of temporal and spectral dynamics of pathologic high-frequency oscillations (pHFOs) during epileptogenesis. Epilepsia. 2015 Dec; 56(12):1879-89. Jones RT, Barth AM, Ormiston LD, Mody I. PMID: 26514993; PMCID: PMC4679703.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. WONOEP appraisal: molecular and cellular imaging in epilepsy. Epilepsia. 2015 Apr; 56(4):505-13. Lillis KP, Dulla C, Maheshwari A, Coulter D, Mody I, Heinemann U, Armbruster M, Žiburkus J. PMID: 25779014; PMCID: PMC4397142.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    24. N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice. Neuron. 2015 Feb 18; 85(4):726-41. Gu X, Cantle JP, Greiner ER, Lee CY, Barth AM, Gao F, Park CS, Zhang Z, Sandoval-Miller S, Zhang RL, Diamond M, Mody I, Coppola G, Yang XW. PMID: 25661181; PMCID: PMC4386927.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    25. GABAergic signaling in health and disease. Neuropharmacology. 2015 Jan; 88:1. McBain CJ, Kittler J, Luscher B, Mody I, Orser BA. PMID: 25305324; PMCID: PMC6333199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    26. In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons. Neuropharmacology. 2015 Jan; 88:91-8. Ferando I, Mody I. PMID: 25261782; PMCID: PMC4410774.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    27. Ovarian cycle-linked plasticity of δ-GABAA receptor subunits in hippocampal interneurons affects γ oscillations in vivo. Front Cell Neurosci. 2014; 8:222. Barth AM, Ferando I, Mody I. PMID: 25157218; PMCID: PMC4128222.
      View in: PubMed   Mentions: 25  
    28. Measuring the steady-state properties of Ca²⁺ indicators with a set of calibrated [Ca²⁺] solutions. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):758-62. Faas GC, Mody I. PMID: 24987134.
      View in: PubMed   Mentions:    Fields:    
    29. Measuring the rate constants of Ca²⁺ indicators. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):763-7. Faas GC, Mody I. PMID: 24987135.
      View in: PubMed   Mentions:    Fields:    
    30. Measuring the Ca²⁺-binding kinetics of proteins. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):691-3. Faas GC, Mody I. PMID: 24987145.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    31. Collecting data to determine the Ca²⁺-binding properties of DM-nitrophen and proteins. Cold Spring Harb Protoc. 2014 Jul 01; 2014(7):768-73. Faas GC, Mody I. PMID: 24987136.
      View in: PubMed   Mentions:    Fields:    
    32. Rosiglitazone prevents the memory deficits induced by amyloid-beta oligomers via inhibition of inflammatory responses. Neurosci Lett. 2014 Aug 22; 578:7-11. Xu S, Guan Q, Wang C, Wei X, Chen X, Zheng B, An P, Zhang J, Chang L, Zhou W, Mody I, Wang Q. PMID: 24933538.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    33. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci. 2014 May; 17(5):694-703. Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS. PMID: 24686787; PMCID: PMC4064471.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansAnimalsCells
    34. Intracellular bicarbonate regulates action potential generation via KCNQ channel modulation. J Neurosci. 2014 Mar 19; 34(12):4409-17. Jones RT, Faas GC, Mody I. PMID: 24647960; PMCID: PMC3960478.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    35. 5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices. PLoS One. 2014; 9(2):e88085. Wawra M, Fidzinski P, Heinemann U, Mody I, Behr J. PMID: 24505387; PMCID: PMC3914937.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. Interneuronal GABAA receptors inside and outside of synapses. Curr Opin Neurobiol. 2014 Jun; 26:57-63. Ferando I, Mody I. PMID: 24650505; PMCID: PMC4024329.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    37. Novel test of motor and other dysfunctions in mouse neurological disease models. J Neurosci Methods. 2014 Jan 15; 221:151-8. Barth AM, Mody I. PMID: 24140423; PMCID: PMC3859435.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    38. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits. 2013; 7:144. Ferando I, Mody I. PMID: 24062647; PMCID: PMC3775147.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    39. Issues related to development of antiepileptogenic therapies. Epilepsia. 2013 Aug; 54 Suppl 4:35-43. Pitkänen A, Nehlig A, Brooks-Kayal AR, Dudek FE, Friedman D, Galanopoulou AS, Jensen FE, Kaminski RM, Kapur J, Klitgaard H, Löscher W, Mody I, Schmidt D. PMID: 23909852; PMCID: PMC3740390.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    40. Epilepsy biomarkers. Epilepsia. 2013 Aug; 54 Suppl 4:61-9. Engel J, Pitkänen A, Loeb JA, Dudek FE, Bertram EH, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A. PMID: 23909854; PMCID: PMC4131763.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimals
    41. Connectomics and epilepsy. Curr Opin Neurol. 2013 Apr; 26(2):186-94. Engel J, Thompson PM, Stern JM, Staba RJ, Bragin A, Mody I. PMID: 23406911; PMCID: PMC4064674.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    42. GABAA receptor modulation by neurosteroids in models of temporal lobe epilepsies. Epilepsia. 2012 Dec; 53 Suppl 9:89-101. Ferando I, Mody I. PMID: 23216582.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    43. Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia. 2012 Nov; 53(11):1868-76. Kobow K, Auvin S, Jensen F, Löscher W, Mody I, Potschka H, Prince D, Sierra A, Simonato M, Pitkänen A, Nehlig A, Rho JM. PMID: 23061663; PMCID: PMC5011430.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    44. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012 Apr 27; 149(3):708-21. Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. PMID: 22541439; PMCID: PMC3375906.
      View in: PubMed   Mentions: 581     Fields:    Translation:HumansAnimalsCells
    45. The reciprocal regulation of stress hormones and GABA(A) receptors. Front Cell Neurosci. 2011 Jan; 6:4. Mody I, Maguire J. PMID: 22319473; PMCID: PMC3268361.
      View in: PubMed   Mentions: 54  
    46. Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron. 2012 Jan 12; 73(1):23-34. Brickley SG, Mody I. PMID: 22243744; PMCID: PMC3399243.
      View in: PubMed   Mentions: 347     Fields:    Translation:HumansAnimalsCells
    47. Measuring the kinetics of calcium binding proteins with flash photolysis. Biochim Biophys Acta. 2012 Aug; 1820(8):1195-204. Faas GC, Mody I. PMID: 22001612; PMCID: PMC3294183.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci. 2011 Jun 01; 31(22):8306-19. Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE. PMID: 21632951; PMCID: PMC3500097.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    49. The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet. 2011 May 29; 43(7):706-11. Gehman LT, Stoilov P, Maguire J, Damianov A, Lin CH, Shiue L, Ares M, Mody I, Black DL. PMID: 21623373; PMCID: PMC3125461.
      View in: PubMed   Mentions: 194     Fields:    Translation:AnimalsCells
    50. Calmodulin as a direct detector of Ca2+ signals. Nat Neurosci. 2011 Mar; 14(3):301-4. Faas GC, Raghavachari S, Lisman JE, Mody I. PMID: 21258328; PMCID: PMC3057387.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    51. Changes in hippocampal neuronal activity during and after unilateral selective hippocampal ischemia in vivo. J Neurosci. 2011 Jan 19; 31(3):851-60. Barth AM, Mody I. PMID: 21248108; PMCID: PMC6632935.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    52. Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Nature. 2010 Nov 11; 468(7321):305-9. Clarkson AN, Huang BS, Macisaac SE, Mody I, Carmichael ST. PMID: 21048709; PMCID: PMC3058798.
      View in: PubMed   Mentions: 408     Fields:    Translation:AnimalsCells
    53. Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy. J Neurosci. 2010 Jun 30; 30(26):8993-9006. Wyeth MS, Zhang N, Mody I, Houser CR. PMID: 20592220; PMCID: PMC3319326.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    54. Embedded neural recording with TinyOS-based wireless-enabled processor modules. IEEE Trans Neural Syst Rehabil Eng. 2010 Apr; 18(2):134-41. Farshchi S, Pesterev A, Nuyujukian P, Guenterberg E, Mody I, Judy JW. PMID: 20071270.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    55. Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons. Nat Neurosci. 2010 Feb; 13(2):205-12. Mann EO, Mody I. PMID: 20023655; PMCID: PMC2843436.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    56. Steroid hormone fluctuations and GABA(A)R plasticity. Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S84-90. Maguire J, Mody I. PMID: 19632051; PMCID: PMC3399241.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    57. Excitability changes related to GABAA receptor plasticity during pregnancy. J Neurosci. 2009 Jul 29; 29(30):9592-601. Maguire J, Ferando I, Simonsen C, Mody I. PMID: 19641122; PMCID: PMC2875247.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    58. Establishing a physiological environment for visualized in vitro brain slice recordings by increasing oxygen supply and modifying aCSF content. J Neurosci Methods. 2009 Oct 15; 183(2):107-13. Hájos N, Mody I. PMID: 19524611; PMCID: PMC2753642.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    59. Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. Epilepsia. 2009 Apr; 50(4):870-9. Elsas SM, Hazany S, Gregory WL, Mody I. PMID: 19175668; PMCID: PMC2861481.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    60. High-frequency oscillations: what is normal and what is not? Epilepsia. 2009 Apr; 50(4):598-604. Engel J, Bragin A, Staba R, Mody I. PMID: 19055491.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansAnimals
    61. Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci. 2008 Nov 12; 28(46):11890-9. Choi DS, Wei W, Deitchman JK, Kharazia VN, Lesscher HM, McMahon T, Wang D, Qi ZH, Sieghart W, Zhang C, Shokat KM, Mody I, Messing RO. PMID: 19005054; PMCID: PMC2688726.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    62. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell. 2008 Oct 31; 135(3):549-60. Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ. PMID: 18984165; PMCID: PMC2673196.
      View in: PubMed   Mentions: 246     Fields:    Translation:AnimalsCells
    63. GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron. 2008 Jul 31; 59(2):207-13. Maguire J, Mody I. PMID: 18667149; PMCID: PMC2875248.
      View in: PubMed   Mentions: 226     Fields:    Translation:AnimalsCells
    64. Silencing-induced metaplasticity in hippocampal cultured neurons. J Neurophysiol. 2008 Aug; 100(2):690-7. Sokolova IV, Mody I. PMID: 18509070; PMCID: PMC2527049.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    65. "One swallow does not make a summer" ... or does it? Epilepsy Curr. 2008 May-Jun; 8(3):73-5. Mody I. PMID: 18488059; PMCID: PMC2384154.
      View in: PubMed   Mentions:
    66. The multifaceted role of inhibition in epilepsy: seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy. Curr Opin Neurol. 2008 Apr; 21(2):155-60. Mann EO, Mody I. PMID: 18317273.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    67. Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus? J Neurosci. 2008 Feb 06; 28(6):1421-6. Glykys J, Mann EO, Mody I. PMID: 18256262; PMCID: PMC6671570.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    68. Activation of GABAA receptors: views from outside the synaptic cleft. Neuron. 2007 Dec 06; 56(5):763-70. Glykys J, Mody I. PMID: 18054854.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    69. Bi-Fi: an embedded sensor/system architecture for REMOTE biological monitoring. IEEE Trans Inf Technol Biomed. 2007 Nov; 11(6):611-8. Farshchi S, Pesterev A, Nuyujukian PH, Mody I, Judy JW. PMID: 18046936.
      View in: PubMed   Mentions: 8     Fields:    
    70. Resolving the fast kinetics of cooperative binding: Ca2+ buffering by calretinin. PLoS Biol. 2007 Nov; 5(11):e311. Faas GC, Schwaller B, Vergara JL, Mody I. PMID: 18044987; PMCID: PMC2229850.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    71. Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol. Neurochem Int. 2008 Jan; 52(1-2):60-4. Mody I. PMID: 17714830; PMCID: PMC2291573.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    72. Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy. J Neurosci. 2007 Jul 11; 27(28):7520-31. Zhang N, Wei W, Mody I, Houser CR. PMID: 17626213; PMCID: PMC6672608.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    73. The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J Physiol. 2007 Aug 01; 582(Pt 3):1163-78. Glykys J, Mody I. PMID: 17525114; PMCID: PMC2075237.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    74. A new meaning for "Gin & Tonic": tonic inhibition as the target for ethanol action in the brain. Alcohol. 2007 May; 41(3):145-53. Mody I, Glykys J, Wei W. PMID: 17521846; PMCID: PMC2012942.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    75. Spike timing of lacunosom-moleculare targeting interneurons and CA3 pyramidal cells during high-frequency network oscillations in vitro. J Neurophysiol. 2007 Jul; 98(1):96-104. Spampanato J, Mody I. PMID: 17475718.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    76. Neurosteroid synthesis-mediated regulation of GABA(A) receptors: relevance to the ovarian cycle and stress. J Neurosci. 2007 Feb 28; 27(9):2155-62. Maguire J, Mody I. PMID: 17329412; PMCID: PMC6673487.
      View in: PubMed   Mentions: 124     Fields:    Translation:Animals
    77. A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol. Nat Neurosci. 2007 Jan; 10(1):40-8. Glykys J, Peng Z, Chandra D, Homanics GE, Houser CR, Mody I. PMID: 17159992.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    78. Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19152-7. Klaassen A, Glykys J, Maguire J, Labarca C, Mody I, Boulter J. PMID: 17146052; PMCID: PMC1681351.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    79. Differences between the scaling of miniature IPSCs and EPSCs recorded in the dendrites of CA1 mouse pyramidal neurons. J Physiol. 2006 Oct 01; 576(Pt 1):191-6. Andrásfalvy BK, Mody I. PMID: 16887875; PMCID: PMC1995648.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    80. A TinyOS-enabled MICA2-based wireless neural interface. IEEE Trans Biomed Eng. 2006 Jul; 53(7):1416-24. Farshchi S, Nuyujukian PH, Pesterev A, Mody I, Judy JW. PMID: 16830946.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    81. Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice. J Neurophysiol. 2006 May; 95(5):2796-807. Glykys J, Mody I. PMID: 16452257.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    82. Recording brain activity wirelessly. Inductive powering in miniature implantable neural recording devices. IEEE Eng Med Biol Mag. 2005 Nov-Dec; 24(6):48-54. Irazoqui PP, Mody I, Judy JW. PMID: 16382805.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    83. A hybrid approach to measuring electrical activity in genetically specified neurons. Nat Neurosci. 2005 Nov; 8(11):1619-26. Chanda B, Blunck R, Faria LC, Schweizer FE, Mody I, Bezanilla F. PMID: 16205716.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    84. Ovarian cycle-linked changes in GABA(A) receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci. 2005 Jun; 8(6):797-804. Maguire JL, Stell BM, Rafizadeh M, Mody I. PMID: 15895085.
      View in: PubMed   Mentions: 321     Fields:    Translation:AnimalsCells
    85. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron. 2005 May 05; 46(3):433-44. Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW. PMID: 15882643.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    86. GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J Neurosci. 2005 Mar 23; 25(12):3234-45. Chiu CS, Brickley S, Jensen K, Southwell A, Mckinney S, Cull-Candy S, Mody I, Lester HA. PMID: 15788781; PMCID: PMC6725086.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    87. Kinetic properties of DM-nitrophen binding to calcium and magnesium. Biophys J. 2005 Jun; 88(6):4421-33. Faas GC, Karacs K, Vergara JL, Mody I. PMID: 15778435; PMCID: PMC1305669.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    88. Aspects of the homeostaic plasticity of GABAA receptor-mediated inhibition. J Physiol. 2005 Jan 01; 562(Pt 1):37-46. Mody I. PMID: 15528237; PMCID: PMC1665492.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    89. Another "tonic" in the realm of epilepsy. Epilepsy Curr. 2004 Nov-Dec; 4(6):248-9. Mody I. PMID: 16059516; PMCID: PMC1176388.
      View in: PubMed   Mentions: 1  
    90. Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy. J Neurosci. 2004 Sep 29; 24(39):8629-39. Peng Z, Huang CS, Stell BM, Mody I, Houser CR. PMID: 15456836; PMCID: PMC6729896.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    91. Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons. J Neurosci. 2004 Sep 22; 24(38):8379-82. Wei W, Faria LC, Mody I. PMID: 15385620; PMCID: PMC6729680.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    92. High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis. Epilepsia. 2004 Sep; 45(9):1017-23. Bragin A, Wilson CL, Almajano J, Mody I, Engel J. PMID: 15329064.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    93. Diversity of inhibitory neurotransmission through GABA(A) receptors. Trends Neurosci. 2004 Sep; 27(9):569-75. Mody I, Pearce RA. PMID: 15331240.
      View in: PubMed   Mentions: 223     Fields:    Translation:AnimalsCells
    94. Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex. J Neurophysiol. 2004 Oct; 92(4):2610-4. Faria LC, Mody I. PMID: 15201313.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    95. A TinyOS-based wireless neural interface. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:4334-7. Farshchi S, Mody I, Judy JW. PMID: 17271263.
      View in: PubMed   Mentions:    Fields:    
    96. Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus. J Neurosci. 2003 Nov 19; 23(33):10650-61. Wei W, Zhang N, Peng Z, Houser CR, Mody I. PMID: 14627650; PMCID: PMC6740905.
      View in: PubMed   Mentions: 203     Fields:    Translation:AnimalsCells
    97. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14439-44. Stell BM, Brickley SG, Tang CY, Farrant M, Mody I. PMID: 14623958; PMCID: PMC283610.
      View in: PubMed   Mentions: 378     Fields:    Translation:HumansAnimalsCells
    98. Calcium and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE). Epilepsy Curr. 2003 Nov; 3(6):221-222. Mody I. PMID: 15346160; PMCID: PMC321217.
      View in: PubMed   Mentions:
    99. A tale of timing and transport. Neuron. 2003 Aug 28; 39(5):729-30. Stell B, Mody I. PMID: 12948438.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    100. Gamma-hydroxybutyrate reduces mitogen-activated protein kinase phosphorylation via GABA B receptor activation in mouse frontal cortex and hippocampus. J Biol Chem. 2003 Oct 24; 278(43):42006-11. Ren X, Mody I. PMID: 12923192.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    101. Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. J Neurophysiol. 2003 Aug; 90(2):786-97. Dalby NO, Mody I. PMID: 12904493.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    102. GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. J Neurophysiol. 2003 Oct; 90(4):2690-701. Jensen K, Chiu CS, Sokolova I, Lester HA, Mody I. PMID: 12815026.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    103. Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci. 2002 Dec 01; 22(23):10251-66. Chiu CS, Jensen K, Sokolova I, Wang D, Li M, Deshpande P, Davidson N, Mody I, Quick MW, Quake SR, Lester HA. PMID: 12451126; PMCID: PMC6758747.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    104. Kindling enhances kainate receptor-mediated depression of GABAergic inhibition in rat granule cells. Eur J Neurosci. 2002 Sep; 16(5):861-7. Behr J, Gebhardt C, Heinemann U, Mody I. PMID: 12372022.
      View in: PubMed   Mentions: 6  Translation:AnimalsCells
    105. The GAD-given Right of Dentate Gyrus Granule Cells to Become GABAergic. Epilepsy Curr. 2002 Sep; 2(5):143-145. Mody I. PMID: 15309121; PMCID: PMC321043.
      View in: PubMed   Mentions: 4  
    106. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. J Neurosci. 2002 May 15; 22(10):RC223. Stell BM, Mody I. PMID: 12006605; PMCID: PMC6757628.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    107. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J Neurophysiol. 2002 May; 87(5):2624-8. Nusser Z, Mody I. PMID: 11976398.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    108. Local generation of fast ripples in epileptic brain. J Neurosci. 2002 Mar 01; 22(5):2012-21. Bragin A, Mody I, Wilson CL, Engel J. PMID: 11880532; PMCID: PMC6758883.
      View in: PubMed   Mentions: 154     Fields:    Translation:Animals
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