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Golshani, Peyman

Title(s)Professor-in-Residence, Neurology
Phone310-254-5604
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    Other Positions
    Title(s)Professor-in-Residence, Psychiatry And Biobehavioral Sciences


    Collapse Research 
    Collapse Research Activities and Funding
    An open source, wireless, miniature microscope for monitoring neuronal activity
    NIH/NINDS UF1NS107668Sep 30, 2018 - Sep 29, 2021
    Role: Co-Principal Investigator
    Epilepsy related cell loss and cognitive dysfunction
    NIH/NINDS R01NS099137Jun 1, 2017 - Jan 31, 2022
    Role: Co-Principal Investigator
    Integrating flexible neural probes with a giant cranial window for combined electrophysiology and 2-photon calcium imaging of cortex-hippocampal interactions
    NIH/NIMH R03MH111241Sep 23, 2016 - Sep 22, 2017
    Role: Principal Investigator
    Building and sharing next generation open-source, wireless, multichannel miniaturized microscopes for imaging activity in freely behaving mice
    NIH/NINDS U01NS094286Sep 30, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Inhibitory neuron circuit organization and function in prefrontal cortex.
    NIH/NIMH R01MH105427Jul 6, 2015 - Mar 31, 2020
    Role: Co-Principal Investigator
    Cerebellar contributions to movement explored with patterned optical manipulation
    NIH/NINDS R01NS090930Sep 15, 2014 - Aug 31, 2019
    Role: Principal Investigator
    Optogenetic treatment of epilepsyassociated
    NIH/NINDS R21NS089396Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Optogenetic treatment of social behavior in autism
    NIH/NIMH R01MH101198Jul 11, 2013 - May 31, 2018
    Role: Principal Investigator
    Hippocampal Interneuron Network Dynamics After Epileptogenesis
    VA I01BX001524Jul 1, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Epigenetic modulation of epileptogenesis.
    NIH/NINDS K08NS056210Aug 1, 2006 - Jul 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kingsbury L, Huang S, Wang J, Gu K, Golshani P, Wu YE, Hong W. Correlated Neural Activity and Encoding of Behavior across Brains of Socially Interacting Animals. Cell. 2019 Jul 11; 178(2):429-446.e16. PMID: 31230711.
      View in: PubMed
    2. Lazaro MT, Taxidis J, Shuman T, Bachmutsky I, Ikrar T, Santos R, Marcello GM, Mylavarapu A, Chandra S, Foreman A, Goli R, Tran D, Sharma N, Azhdam M, Dong H, Choe KY, Peñagarikano O, Masmanidis SC, Rácz B, Xu X, Geschwind DH, Golshani P. Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Cell Rep. 2019 May 28; 27(9):2567-2578.e6. PMID: 31141683.
      View in: PubMed
    3. Octeau JC, Gangwani MR, Allam SL, Tran D, Huang S, Hoang-Trong TM, Golshani P, Rumbell TH, Kozloski JR, Khakh BS. Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation. Cell Rep. 2019 05 21; 27(8):2249-2261.e7. PMID: 31116972.
      View in: PubMed
    4. Arac A, Zhao P, Dobkin BH, Carmichael ST, Golshani P. DeepBehavior: A Deep Learning Toolbox for Automated Analysis of Animal and Human Behavior Imaging Data. Front Syst Neurosci. 2019; 13:20. PMID: 31133826.
      View in: PubMed
    5. Aharoni D, Khakh BS, Silva AJ, Golshani P. All the light that we can see: a new era in miniaturized microscopy. Nat Methods. 2019 Jan; 16(1):11-13. PMID: 30573833.
      View in: PubMed
    6. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 09 10; 28(17):R909-R914. PMID: 30205056.
      View in: PubMed
    7. Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS. Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior. Neuron. 2018 09 19; 99(6):1170-1187.e9. PMID: 30174118.
      View in: PubMed
    8. Meyer JF, Golshani P, Smirnakis SM. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1. Front Neural Circuits. 2018; 12:29. PMID: 29713266.
      View in: PubMed
    9. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. PMID: 29020636.
      View in: PubMed
    10. Einstein MC, Polack PO, Tran DT, Golshani P. Visually Evoked 3-5 Hz Membrane Potential Oscillations Reduce the Responsiveness of Visual Cortex Neurons in Awake Behaving Mice. J Neurosci. 2017 05 17; 37(20):5084-5098. PMID: 28432140.
      View in: PubMed
    11. Shuman T, Amendolara B, Golshani P. Theta Rhythmopathy as a Cause of Cognitive Disability in TLE. Epilepsy Curr. 2017 Mar-Apr; 17(2):107-111. PMID: 28491003.
      View in: PubMed
    12. Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS. New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron. 2016 Dec 21; 92(6):1181-1195. PMID: 27939582.
      View in: PubMed
    13. Cantero G, Liu XB, Mervis RF, Lazaro MT, Cederbaum SD, Golshani P, Lipshutz GS. Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy. J Neurosci. 2016 06 22; 36(25):6680-90. PMID: 27335400.
      View in: PubMed
    14. Cai DJ, Aharoni D, Shuman T, Shobe J, Biane J, Song W, Wei B, Veshkini M, La-Vu M, Lou J, Flores SE, Kim I, Sano Y, Zhou M, Baumgaertel K, Lavi A, Kamata M, Tuszynski M, Mayford M, Golshani P, Silva AJ. A shared neural ensemble links distinct contextual memories encoded close in time. Nature. 2016 06 02; 534(7605):115-8. PMID: 27251287.
      View in: PubMed
    15. Gdalyahu A, Lazaro M, Penagarikano O, Golshani P, Trachtenberg JT, Geschwind DH, Gescwind DH. The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. PLoS One. 2015; 10(5):e0125633. PMID: 25951243.
      View in: PubMed
    16. Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS. Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo. Nat Neurosci. 2015 May; 18(5):708-17. PMID: 25894291.
      View in: PubMed
    17. Lázaro MT, Golshani P. The utility of rodent models of autism spectrum disorders. Curr Opin Neurol. 2015 Apr; 28(2):103-9. PMID: 25734952.
      View in: PubMed
    18. Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Sci Transl Med. 2015 Jan 21; 7(271):271ra8. PMID: 25609168.
      View in: PubMed
    19. Garcia-Junco-Clemente P, Golshani P. PTEN: A master regulator of neuronal structure, function, and plasticity. Commun Integr Biol. 2014 Jan 01; 7(1):e28358. PMID: 24778766.
      View in: PubMed
    20. Mehta SQ, Golshani P. Clinical neurogenetics: autism spectrum disorders. Neurol Clin. 2013 Nov; 31(4):951-68. PMID: 24176418.
      View in: PubMed
    21. Garcia-Junco-Clemente P, Chow DK, Tring E, Lazaro MT, Trachtenberg JT, Golshani P. Overexpression of calcium-activated potassium channels underlies cortical dysfunction in a model of PTEN-associated autism. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18297-302. PMID: 24145404.
      View in: PubMed
    22. Polack PO, Friedman J, Golshani P. Cellular mechanisms of brain state-dependent gain modulation in visual cortex. Nat Neurosci. 2013 Sep; 16(9):1331-9. PMID: 23872595.
      View in: PubMed
    23. Gonçalves JT, Anstey JE, Golshani P, Portera-Cailliau C. Circuit level defects in the developing neocortex of Fragile X mice. Nat Neurosci. 2013 Jul; 16(7):903-9. PMID: 23727819.
      View in: PubMed
    24. Gdalyahu A, Tring E, Polack PO, Gruver R, Golshani P, Fanselow MS, Silva AJ, Trachtenberg JT. Associative fear learning enhances sparse network coding in primary sensory cortex. Neuron. 2012 Jul 12; 75(1):121-32. PMID: 22794266.
      View in: PubMed
    25. Peñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 2011 Sep 30; 147(1):235-46. PMID: 21962519.
      View in: PubMed
    26. Cheng A, Gonçalves JT, Golshani P, Arisaka K, Portera-Cailliau C. Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing. Nat Methods. 2011 Feb; 8(2):139-42. PMID: 21217749.
      View in: PubMed
    27. Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C. Internally mediated developmental desynchronization of neocortical network activity. J Neurosci. 2009 Sep 02; 29(35):10890-9. PMID: 19726647.
      View in: PubMed
    28. Hutnick LK, Golshani P, Namihira M, Xue Z, Matynia A, Yang XW, Silva AJ, Schweizer FE, Fan G. DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Hum Mol Genet. 2009 Aug 01; 18(15):2875-88. PMID: 19433415.
      View in: PubMed
    29. Ratnaparkhi A, Lawless GM, Schweizer FE, Golshani P, Jackson GR. A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism. PLoS One. 2008 Jun 04; 3(6):e2334. PMID: 18523548.
      View in: PubMed
    30. Golshani P, Portera-Cailliau C. In vivo 2-photon calcium imaging in layer 2/3 of mice. J Vis Exp. 2008 Mar 13; (13). PMID: 19066575.
      View in: PubMed
    31. Golshani P, Hutnick L, Schweizer F, Fan G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus Relat Syst. 2005 Sep; 3(3):227-233. PMID: 17710197.
      View in: PubMed