Loading...

Hsiai Tzung

Title(s)Member, CTSI
SchoolCTSI
vCardDownload vCard
    Other Positions
    Title(s)Member, California NanoSystems Institute

    Title(s)Director Cardiovascular Engineering Research Laboratory, SEAS

    Title(s)Professor, Bioengineering

    Title(s)Member, Molecular Cellular & Integrative Physiology GPB Home Area


    Collapse Research 
    Collapse Research Activities and Funding
    Exercise-Induced Shear Stress Modulates Metabolic Pathways for Vascular Repair and Protection
    VA I01BX004356Jan 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Role of Intestinal Microbiota in Dyslipidemia and Atherosclerosis Induced by Ambient Ultrafine Particles
    NIH/NIEHS R01ES029395Sep 30, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Shear Stress and Light-Sheets to Study Cardiac Trabeculation
    NIH/NHLBI R01HL129727Jul 9, 2015 - Jun 30, 2019
    Role: Principal Investigator
    Electrochemical Impedance Spectroscopy to Assess Metabolically Active Plaque
    NIH/NHLBI R01HL118650Jul 10, 2014 - Mar 31, 2023
    Role: Principal Investigator
    Micro-Sensors to Study Electrical and Mechanical Coupling of Injured Myocardium
    NIH/NHLBI R01HL111437Mar 1, 2012 - Mar 31, 2021
    Role: Principal Investigator
    Shear Stress and Mechnaically Unstable Plaque
    NIH/NHLBI R21HL091302Jul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Linking Spatial Variations in Shear Stress with Oxidation Stress
    NIH/NHLBI R01HL083015Jan 1, 2006 - May 31, 2016
    Role: Principal Investigator
    Microsensors to Study Endothelial Cell Dynamics
    NIH/NHLBI K08HL068689Jan 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    OXIDATIVE AND ATHEROGENIC ACTION OF IN VIVO MODIFIED LDL
    NIH/NHLBI R01HL050350Aug 1, 1995 - May 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Feng J, Cavallero S, Hsiai T, Li R. Impact of air pollution on intestinal redox lipidome and microbiome. Free Radic Biol Med. 2020 Jan 02. PMID: 31904545.
      View in: PubMed
    2. Yang Y, Song Y, Bo X, Min J, Pak OS, Zhu L, Wang M, Tu J, Kogan A, Zhang H, Hsiai TK, Li Z, Gao W. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat Biotechnol. 2019 Nov 25. PMID: 31768044.
      View in: PubMed
    3. Ding Y, Dvornikov AV, Ma X, Zhang H, Wang Y, Lowerison M, Packard RR, Wang L, Chen J, Zhang Y, Hsiai T, Lin X, Xu X. Haploinsufficiency of mechanistic target of rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish. Dis Model Mech. 2019 10 01; 12(10). PMID: 31492659.
      View in: PubMed
    4. Li R, Baek KI, Chang CC, Zhou B, Hsiai TK. Mechanosensitive Pathways Involved in Cardiovascular Development and Homeostasis in Zebrafish. J Vasc Res. 2019; 56(6):273-283. PMID: 31466069.
      View in: PubMed
    5. Chen J, Ding Y, Chen M, Gau J, Jen N, Nahal C, Tu S, Chen C, Zhou S, Chang CC, Lyu J, Xu X, Hsiai TK, Packard RRS. Displacement analysis of myocardial mechanical deformation (DIAMOND) reveals segmental susceptibility to doxorubicin-induced injury and regeneration. JCI Insight. 2019 Apr 18; 4(8). PMID: 30996130.
      View in: PubMed
    6. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. JCI Insight. 2019 Apr 11; 5. PMID: 30973827.
      View in: PubMed
    7. Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Dev Cell. 2019 03 11; 48(5):617-630.e3. PMID: 30799229.
      View in: PubMed
    8. Vedula V, Lee J, Xu H, Jay Kuo CC, Hsiai TK, Marsden AL. Correction: A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling. PLoS Comput Biol. 2018 09; 14(9):e1006482. PMID: 30222742.
      View in: PubMed
    9. Ding Y, Bailey Z, Messerschmidt V, Nie J, Bryant R, Rugonyi S, Fei P, Lee J, Hsiai TK. Light-sheet Fluorescence Microscopy for the Study of the Murine Heart. J Vis Exp. 2018 09 15; (139). PMID: 30272656.
      View in: PubMed
    10. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). PMID: 30135307.
      View in: PubMed
    11. Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach. Ann Biomed Eng. 2018 Dec; 46(12):2177-2188. PMID: 30112710.
      View in: PubMed
    12. Messerschmidt V, Bailey Z, Baek KI, Bryant R, Li R, Hsiai TK, Lee J. Light-sheet Fluorescence Microscopy to Capture 4-Dimensional Images of the Effects of Modulating Shear Stress on the Developing Zebrafish Heart. J Vis Exp. 2018 08 10; (138). PMID: 30148501.
      View in: PubMed
    13. Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13). PMID: 29997298.
      View in: PubMed
    14. Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging. Prog Biophys Mol Biol. 2018 10; 138:105-115. PMID: 29752956.
      View in: PubMed
    15. Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 03 24; 20(5):35. PMID: 29574550.
      View in: PubMed
    16. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat Commun. 2018 02 21; 9(1):754. PMID: 29467410.
      View in: PubMed
    17. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1203-H1213. PMID: 29451816.
      View in: PubMed
    18. Luo Y, Abiri P, Zhang S, Chang CC, Kaboodrangi AH, Li R, Sahib AK, Bui A, Kumar R, Woo M, Li Z, Packard RRS, Tai YC, Hsiai TK. Non-Invasive Electrical Impedance Tomography for Multi-Scale Detection of Liver Fat Content. Theranostics. 2018; 8(6):1636-1647. PMID: 29556346.
      View in: PubMed
    19. Lenning M, Fortunato J, Le T, Clark I, Sherpa A, Yi S, Hofsteen P, Thamilarasu G, Yang J, Xu X, Han HD, Hsiai TK, Cao H. Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection. Sensors (Basel). 2017 Dec 28; 18(1). PMID: 29283402.
      View in: PubMed
    20. Chang SS, Tu S, Baek KI, Pietersen A, Liu YH, Savage VM, Hwang SL, Hsiai TK, Roper M. Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network. PLoS Comput Biol. 2017 12; 13(12):e1005892. PMID: 29244812.
      View in: PubMed
    21. Baek KI, Packard RRS, Hsu JJ, Saffari A, Ma Z, Luu AP, Pietersen A, Yen H, Ren B, Ding Y, Sioutas C, Li R, Hsiai TK. Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration. Antioxid Redox Signal. 2018 05 01; 28(13):1209-1223. PMID: 29037123.
      View in: PubMed
    22. Ding Y, Abiri A, Abiri P, Li S, Chang CC, Baek KI, Hsu JJ, Sideris E, Li Y, Lee J, Segura T, Nguyen TP, Bui A, Sevag Packard RR, Fei P, Hsiai TK. Integrating light-sheet imaging with virtual reality to recapitulate developmental cardiac mechanics. JCI Insight. 2017 11 16; 2(22). PMID: 29202458.
      View in: PubMed
    23. Vedula V, Lee J, Xu H, Kuo CJ, Hsiai TK, Marsden AL. A method to quantify mechanobiologic forces during zebrafish cardiac development using 4-D light sheet imaging and computational modeling. PLoS Comput Biol. 2017 Oct; 13(10):e1005828. PMID: 29084212.
      View in: PubMed
    24. Baek KI, Li R, Jen N, Choi H, Kaboodrangi A, Ping P, Liem D, Beebe T, Hsiai TK. Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair. Antioxid Redox Signal. 2018 Jan 01; 28(1):31-43. PMID: 28762754.
      View in: PubMed
    25. Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 08 17; 7(1):8603. PMID: 28819303.
      View in: PubMed
    26. Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system. Sci Rep. 2017 07 21; 7(1):6180. PMID: 28733677.
      View in: PubMed
    27. Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics. 2017; 7(9):2431-2442. PMID: 28744325.
      View in: PubMed
    28. Lee J, Chou TC, Kang D, Kang H, Chen J, Baek KI, Wang W, Ding Y, Carlo DD, Tai YC, Hsiai TK. A Rapid Capillary-Pressure Driven Micro-Channel to Demonstrate Newtonian Fluid Behavior of Zebrafish Blood at High Shear Rates. Sci Rep. 2017 05 16; 7(1):1980. PMID: 28512313.
      View in: PubMed
    29. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res. 2017 04 14; 120(8):1240-1242. PMID: 28408452.
      View in: PubMed
    30. Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites. Sci Rep. 2017 02 17; 7:42906. PMID: 28211537.
      View in: PubMed
    31. Ding Y, Lee J, Ma J, Sung K, Yokota T, Singh N, Dooraghi M, Abiri P, Wang Y, Kulkarni RP, Nakano A, Nguyen TP, Fei P, Hsiai TK. Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution. Sci Rep. 2017 02 06; 7:42209. PMID: 28165052.
      View in: PubMed
    32. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A, Kulkarni RP. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping. Sci Rep. 2016 08 08; 6:30736. PMID: 27498769.
      View in: PubMed
    33. Lee J, Fei P, Sevag Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 08 01; 126(8):3158. PMID: 27479748.
      View in: PubMed
    34. Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques. Sens Actuators B Chem. 2016 Nov 01; 235:154-161. PMID: 27773967.
      View in: PubMed
    35. Lee J, Fei P, Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 05 02; 126(5):1679-90. PMID: 27018592.
      View in: PubMed
    36. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Sci Rep. 2016 Mar 03; 6:22489. PMID: 26935567.
      View in: PubMed
    37. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 09; 44(9):2695-706. PMID: 26857007.
      View in: PubMed
    38. Guan Z, Lee J, Jiang H, Dong S, Jen N, Hsiai T, Ho CM, Fei P. Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope. Biomed Opt Express. 2016 Jan 01; 7(1):194-208. PMID: 26819828.
      View in: PubMed
    39. Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics. Curr Opin Lipidol. 2015 Oct; 26(5):376-83. PMID: 26218416.
      View in: PubMed
    40. Ma T, Zhou B, Hsiai TK, Shung KK. A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging: The Synergistic Approach to Characterizing Vulnerable Plaques. Ultrason Imaging. 2016 09; 38(5):314-31. PMID: 26400676.
      View in: PubMed
    41. Fei C, Ma J, Chiu CT, Williams JA, Fong W, Chen Z, Zhu B, Xiong R, Shi J, Hsiai TK, Shung KK, Zhou Q. Design of matching layers for high-frequency ultrasonic transducers. Appl Phys Lett. 2015 Sep 21; 107(12):123505. PMID: 26445518.
      View in: PubMed
    42. Li R, Jen N, Wu L, Lee J, Fang K, Quigley K, Lee K, Wang S, Zhou B, Vergnes L, Chen YR, Li Z, Reue K, Ann DK, Hsiai TK. Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis. Antioxid Redox Signal. 2015 Nov 20; 23(15):1207-19. PMID: 26120766.
      View in: PubMed
    43. Yang H, Fang L, Zhan R, Hegarty JM, Ren J, Hsiai TK, Gleeson JG, Miller YI, Trejo J, Chi NC. Polo-like kinase 2 regulates angiogenic sprouting and blood vessel development. Dev Biol. 2015 Aug 15; 404(2):49-60. PMID: 26004360.
      View in: PubMed
    44. Cao H, Kang BJ, Lee CA, Shung KK, Hsiai TK. Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration. IEEE Rev Biomed Eng. 2015; 8:114-24. PMID: 25974948.
      View in: PubMed
    45. Zhang X, Beebe T, Jen N, Lee CA, Tai Y, Hsiai TK. Flexible and waterproof micro-sensors to uncover zebrafish circadian rhythms: The next generation of cardiac monitoring for drug screening. Biosens Bioelectron. 2015 Sep 15; 71:150-157. PMID: 25909335.
      View in: PubMed
    46. Zhao Y, Cao H, Beebe T, Zhang H, Zhang X, Chang H, Scremin O, Lien CL, Tai YC, Hsiai TK. Dry-contact microelectrode membranes for wireless detection of electrical phenotypes in neonatal mouse hearts. Biomed Microdevices. 2015 Apr; 17(2):40. PMID: 25749638.
      View in: PubMed
    47. Lee J, Cao H, Kang BJ, Jen N, Yu F, Lee CA, Fei P, Park J, Bohlool S, Lash-Rosenberg L, Shung KK, Hsiai TK. Hemodynamics and ventricular function in a zebrafish model of injury and repair. Zebrafish. 2014 Oct; 11(5):447-54. PMID: 25237983.
      View in: PubMed
    48. Li R, Navab K, Hough G, Daher N, Zhang M, Mittelstein D, Lee K, Pakbin P, Saffari A, Bhetraratana M, Sulaiman D, Beebe T, Wu L, Jen N, Wine E, Tseng CH, Araujo JA, Fogelman A, Sioutas C, Navab M, Hsiai TK. Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine. Environ Health Perspect. 2015 Jan; 123(1):34-41. PMID: 25170928.
      View in: PubMed
    49. Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK. Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos. Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2268-75. PMID: 25147335.
      View in: PubMed
    50. Cao H, Yu F, Zhao Y, Zhang X, Tai J, Lee J, Darehzereshki A, Bersohn M, Lien CL, Chi NC, Tai YC, Hsiai TK. Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium. Integr Biol (Camb). 2014 Aug; 6(8):789-95. PMID: 24945366.
      View in: PubMed
    51. Hsiai T, Li S, Bursac N. Introduction to the special issue on tissue engineering and regenerative medicine. Ann Biomed Eng. 2014 Jul; 42(7):1355-6. PMID: 24923380.
      View in: PubMed
    52. Dickover M, Hegarty JM, Ly K, Lopez D, Yang H, Zhang R, Tedeschi N, Hsiai TK, Chi NC. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev Biol. 2014 May 15; 389(2):182-91. PMID: 24607366.
      View in: PubMed
    53. Cao H, Yu F, Zhao Y, Scianmarello N, Lee J, Dai W, Jen N, Beebe T, Li R, Ebrahimi R, Chang DS, Mody FV, Pacella J, Tai YC, Hsiai T. Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits. Biosens Bioelectron. 2014 Apr 15; 54:610-6. PMID: 24333932.
      View in: PubMed
    54. Lee J, Moghadam ME, Kung E, Cao H, Beebe T, Miller Y, Roman BL, Lien CL, Chi NC, Marsden AL, Hsiai TK. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis. PLoS One. 2013; 8(8):e72924. PMID: 24009714.
      View in: PubMed
    55. Du Y, Navab M, Shen M, Hill J, Pakbin P, Sioutas C, Hsiai TK, Li R. Ambient ultrafine particles reduce endothelial nitric oxide production via S-glutathionylation of eNOS. Biochem Biophys Res Commun. 2013 Jul 05; 436(3):462-6. PMID: 23751346.
      View in: PubMed
    56. Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T. Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice. J Lipid Res. 2013 Jun; 54(6):1608-15. PMID: 23564731.
      View in: PubMed
    57. Yu F, Lee J, Jen N, Li X, Zhang Q, Tang R, Zhou Q, Kim ES, Hsiai TK. Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions. Biosens Bioelectron. 2013 May 15; 43:237-44. PMID: 23318546.
      View in: PubMed
    58. Li R, Mittelstein D, Kam W, Pakbin P, Du Y, Tintut Y, Navab M, Sioutas C, Hsiai T. Atmospheric ultrafine particles promote vascular calcification via the NF-?B signaling pathway. Am J Physiol Cell Physiol. 2013 Feb 15; 304(4):C362-9. PMID: 23242187.
      View in: PubMed
    59. Jen N, Yu F, Lee J, Wasmund S, Dai X, Chen C, Chawareeyawong P, Yang Y, Li R, Hamdan MH, Hsiai TK. Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function. Biomech Model Mechanobiol. 2013 Aug; 12(4):735-45. PMID: 22983703.
      View in: PubMed
    60. Yu F, Zhao Y, Gu J, Quigley KL, Chi NC, Tai YC, Hsiai TK. Flexible microelectrode arrays to interface epicardial electrical signals with intracardial calcium transients in zebrafish hearts. Biomed Microdevices. 2012 Apr; 14(2):357-66. PMID: 22124886.
      View in: PubMed
    61. Li R, Mittelstein D, Fang K, Beebe T, Quigley K, Berliner J, Hsiai TK. Angiopoeitin-2 modulates Survivin expression in OxLDL-induced endothelial cell apoptosis. Biochem Biophys Res Commun. 2012 Jan 06; 417(1):619-22. PMID: 22182412.
      View in: PubMed
    62. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases. Am J Physiol Cell Physiol. 2012 Feb 15; 302(4):C658-65. PMID: 22031601.
      View in: PubMed
    63. Li R, Jen N, Yu F, Hsiai TK. Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress. Curr Protoc Cytom. 2011 Oct; Chapter 9:Unit9.37. PMID: 21965108.
      View in: PubMed
    64. Yu F, Dai X, Beebe T, Hsiai T. Electrochemical impedance spectroscopy to characterize inflammatory atherosclerotic plaques. Biosens Bioelectron. 2011 Dec 15; 30(1):165-73. PMID: 21959227.
      View in: PubMed
    65. Takabe W, Jen N, Ai L, Hamilton R, Wang S, Holmes K, Dharbandi F, Khalsa B, Bressler S, Barr ML, Li R, Hsiai TK. Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling. Antioxid Redox Signal. 2011 Sep 01; 15(5):1379-88. PMID: 20919940.
      View in: PubMed
    66. Yu F, Ai L, Dai W, Rozengurt N, Yu H, Hsiai TK. MEMS thermal sensors to detect changes in heat transfer in the pre-atherosclerotic regions of fat-fed New Zealand white rabbits. Ann Biomed Eng. 2011 Jun; 39(6):1736-44. PMID: 21380571.
      View in: PubMed
    67. Yu F, Huang J, Adlerz K, Jadvar H, Hamdan MH, Chi N, Chen JN, Hsiai TK. Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity. Zebrafish. 2010 Dec; 7(4):325-31. PMID: 20958244.
      View in: PubMed
    68. Masood SO, Wasmund SL, Akoum NW, Egger MJ, Hsiai T, Hamdan MH. The effects of rate and rhythm control on blood pressure and antihypertensive drug usage in patients with atrial fibrillation and hypertension enrolled in the AFFIRM trial. J Cardiovasc Electrophysiol. 2010 Oct; 21(10):1094-8. PMID: 20455988.
      View in: PubMed
    69. Yu F, Li R, Ai L, Edington C, Yu H, Barr M, Kim ES, Hsiai TK. Electrochemical impedance spectroscopy to assess vascular oxidative stress. Ann Biomed Eng. 2011 Jan; 39(1):287-96. PMID: 20652746.
      View in: PubMed
    70. Ai L, Zhang L, Dai W, Hu C, Shung KK, Hsiai TK. Real-time assessment of flow reversal in an eccentric arterial stenotic model. J Biomech. 2010 Oct 19; 43(14):2678-83. PMID: 20655537.
      View in: PubMed
    71. Li R, Ning Z, Cui J, Yu F, Sioutas C, Hsiai T. Diesel exhaust particles modulate vascular endothelial cell permeability: implication of ZO-1 expression. Toxicol Lett. 2010 Sep 01; 197(3):163-8. PMID: 20576493.
      View in: PubMed
    72. Li R, Ning Z, Majumdar R, Cui J, Takabe W, Jen N, Sioutas C, Hsiai T. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling. Part Fibre Toxicol. 2010 Mar 22; 7:6. PMID: 20307321.
      View in: PubMed
    73. Yu F, Li R, Parks E, Takabe W, Hsiai TK. Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals. Ann Biomed Eng. 2010 Jul; 38(7):2346-57. PMID: 20221900.
      View in: PubMed
    74. Takabe W, Li R, Ai L, Yu F, Berliner JA, Hsiai TK. Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis. Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):436-41. PMID: 20139358.
      View in: PubMed
    75. Li R, Beebe T, Cui J, Rouhanizadeh M, Ai L, Wang P, Gundersen M, Takabe W, Hsiai TK. Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):406-12. PMID: 19666009.
      View in: PubMed
    76. Ai L, Yu H, Dai W, Hale SL, Kloner RA, Hsiai TK. Real-time intravascular shear stress in the rabbit abdominal aorta. IEEE Trans Biomed Eng. 2009 Jun; 56(6):1755-64. PMID: 19527952.
      View in: PubMed
    77. Ai L, Yu H, Takabe W, Paraboschi A, Yu F, Kim ES, Li R, Hsiai TK. Optimization of intravascular shear stress assessment in vivo. J Biomech. 2009 Jul 22; 42(10):1429-37. PMID: 19457490.
      View in: PubMed
    78. Sun P, Zhang Y, Yu F, Parks E, Lyman A, Wu Q, Ai L, Hu CH, Zhou Q, Shung K, Lien CL, Hsiai TK. Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart. Ann Biomed Eng. 2009 May; 37(5):890-901. PMID: 19280341.
      View in: PubMed
    79. Ai L, Hsiai TK. Spatial mapping of real-time quantitative shear stress with vascular oxidative stress. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6557-9. PMID: 19964904.
      View in: PubMed
    80. Li R, Ning Z, Cui J, Khalsa B, Ai L, Takabe W, Beebe T, Majumdar R, Sioutas C, Hsiai T. Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation. Free Radic Biol Med. 2009 Mar 15; 46(6):775-82. PMID: 19154785.
      View in: PubMed
    81. Hsiai TK, Wu JC. Hemodynamic forces regulate embryonic stem cell commitment to vascular progenitors. Curr Cardiol Rev. 2008 Nov; 4(4):269-74. PMID: 20066134.
      View in: PubMed
    82. Hamilton RT, Asatryan L, Nilsen JT, Isas JM, Gallaher TK, Sawamura T, Hsiai TK. LDL protein nitration: implication for LDL protein unfolding. Arch Biochem Biophys. 2008 Nov 01; 479(1):1-14. PMID: 18713619.
      View in: PubMed
    83. Ai L, Rouhanizadeh M, Wu JC, Takabe W, Yu H, Alavi M, Li R, Chu Y, Miller J, Heistad DD, Hsiai TK. Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1576-85. PMID: 18434620.
      View in: PubMed
    84. Hsiai TK. Mechanosignal transduction coupling between endothelial and smooth muscle cells: role of hemodynamic forces. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C659-61. PMID: 18344280.
      View in: PubMed
    85. Rouhanizadeh M, Takabe W, Ai L, Yu H, Hsiai T. Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies. Methods Enzymol. 2008; 441:111-50. PMID: 18554532.
      View in: PubMed
    86. Hsiai T, Berliner JA. Oxidative stress as a regulator of murine atherosclerosis. Curr Drug Targets. 2007 Dec; 8(12):1222-9. PMID: 18220699.
      View in: PubMed
    87. Chang GY, Cao F, Krishnan M, Huang M, Li Z, Xie X, Sheikh AY, Hoyt G, Robbins RC, Hsiai T, Schneider MD, Wu JC. Positron emission tomography imaging of conditional gene activation in the heart. J Mol Cell Cardiol. 2007 Jul; 43(1):18-26. PMID: 17467733.
      View in: PubMed
    88. Hsiai TK, Hwang J, Barr ML, Correa A, Hamilton R, Alavi M, Rouhanizadeh M, Cadenas E, Hazen SL. Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med. 2007 Feb 15; 42(4):519-29. PMID: 17275684.
      View in: PubMed
    89. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. Mechanical response of a calcified plaque model to fluid shear force. Ann Biomed Eng. 2006 Oct; 34(10):1535-41. PMID: 17006755.
      View in: PubMed
    90. Hwang J, Rouhanizadeh M, Hamilton RT, Lin TC, Eiserich JP, Hodis HN, Hsiai TK. 17beta-Estradiol reverses shear-stress-mediated low density lipoprotein modifications. Free Radic Biol Med. 2006 Aug 15; 41(4):568-78. PMID: 16863990.
      View in: PubMed
    91. Hwang J, Hodis HN, Hsiai TK, Asatryan L, Sevanian A. Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins. Atherosclerosis. 2006 Nov; 189(1):76-82. PMID: 16386257.
      View in: PubMed
    92. Rouhanizadeh M, Lin TC, Arcas D, Hwang J, Hsiai TK. Spatial variations in shear stress in a 3-D bifurcation model at low Reynolds numbers. Ann Biomed Eng. 2005 Oct; 33(10):1360-74. PMID: 16240085.
      View in: PubMed
    93. DeMaio L, Rouhanizadeh M, Reddy S, Sevanian A, Hwang J, Hsiai TK. Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H674-83. PMID: 16172163.
      View in: PubMed
    94. Rouhanizadeh M, Hwang J, Clempus RE, Marcu L, Lassègue B, Sevanian A, Hsiai TK. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. Free Radic Biol Med. 2005 Dec 01; 39(11):1512-22. PMID: 16274886.
      View in: PubMed
    95. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses. Ann Biomed Eng. 2004 Feb; 32(2):189-201. PMID: 15008367.
      View in: PubMed
    96. Rouhanizadeh M, Tang T, Li C, DeMaio L, Zhou C, Hsiai T. Detection of oxidized low density lipoproteins by indium oxide nanowires-based field effect transistor. Conf Proc IEEE Eng Med Biol Soc. 2004; 1:204-7. PMID: 17271645.
      View in: PubMed
    97. Soundararajan G, Hsiai TK, DeMaio L, Chang M, Chang S. MEMS shear stress sensors for cardiovascular diagnostics. Conf Proc IEEE Eng Med Biol Soc. 2004; 4:2420-3. PMID: 17270760.
      View in: PubMed
    98. Hwang J, Ing MH, Salazar A, Lassègue B, Griendling K, Navab M, Sevanian A, Hsiai TK. Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Circ Res. 2003 Dec 12; 93(12):1225-32. PMID: 14593003.
      View in: PubMed
    99. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003 Sep; 17(12):1648-57. PMID: 12958171.
      View in: PubMed
    100. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt). Ann Biomed Eng. 2002 May; 30(5):646-56. PMID: 12108839.
      View in: PubMed
    101. Hsiai TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM. Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol. 2001 Nov; 21(11):1770-6. PMID: 11701464.
      View in: PubMed
    102. Honda HM, Hsiai T, Wortham CM, Chen M, Lin H, Navab M, Demer LL. A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells. Atherosclerosis. 2001 Oct; 158(2):385-90. PMID: 11583717.
      View in: PubMed
    103. Detrano R, Hsiai T, Wang S, Puentes G, Fallavollita J, Shields P, Stanford W, Wolfkiel C, Georgiou D, Budoff M, Reed J. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography. J Am Coll Cardiol. 1996 Feb; 27(2):285-90. PMID: 8557895.
      View in: PubMed
    Tzung's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (428) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (33) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑