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Hsiai, Tzung

Title(s)Professor-in-Residence, Medicine
Phone310-478-3711
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    Collapse Research 
    Collapse Research Activities and Funding
    Intravascular Deployment of a Wirelessly Powered Micro-Pacer
    NIH/NHLBI R01HL149808Feb 5, 2020 - Jan 31, 2024
    Role: Principal Investigator
    Exercise-Induced Shear Stress Modulates Metabolic Pathways for Vascular Repair and Protection
    VA I01BX004356Jan 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Role of Intestinal Microbiota in Dyslipidemia and Atherosclerosis Induced by Ambient Ultrafine Particles
    NIH/NIEHS R01ES029395Sep 30, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Shear Stress and Light-Sheets to Study Cardiac Trabeculation
    NIH/NHLBI R01HL129727Jul 9, 2015 - Jun 30, 2019
    Role: Principal Investigator
    Electrochemical Impedance Spectroscopy to Assess Metabolically Active Plaque
    NIH/NHLBI R01HL118650Jul 10, 2014 - May 31, 2018
    Role: Principal Investigator
    Micro-Sensors to Study Electrical and Mechanical Coupling of Injured Myocardium
    NIH/NHLBI R01HL111437Mar 1, 2012 - Mar 31, 2021
    Role: Principal Investigator
    Shear Stress and Mechnaically Unstable Plaque
    NIH/NHLBI R21HL091302Jul 1, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Linking Spatial Variations in Shear Stress with Oxidation Stress
    NIH/NHLBI R01HL083015Aug 1, 2006 - May 31, 2016
    Role: Principal Investigator
    Microsensors to Study Endothelial Cell Dynamics
    NIH/NHLBI K08HL068689Jan 1, 2003 - Dec 31, 2008
    Role: Principal Investigator
    OXIDATIVE AND ATHEROGENIC ACTION OF IN VIVO MODIFIED LDL
    NIH/NHLBI R01HL050350Aug 1, 1995 - May 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Abiri P, Abiri A, Gudapati V, Chang CC, Roustaei M, Bourenane H, Anwar U, Markovic D, Hsiai TK. Wireless Pacing Using an Asynchronous Three-Tiered Inductive Power Transfer System. Ann Biomed Eng. 2020 Jan 23. PMID: 31974869.
      View in: PubMed
    2. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. JCI Insight. 2019 Apr 11; 5. PMID: 30973827.
      View in: PubMed
    3. Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Dev Cell. 2019 03 11; 48(5):617-630.e3. PMID: 30799229.
      View in: PubMed
    4. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). PMID: 30135307.
      View in: PubMed
    5. Abiri A, Ding Y, Abiri P, Packard RRS, Vedula V, Marsden A, Kuo CJ, Hsiai TK. Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach. Ann Biomed Eng. 2018 Dec; 46(12):2177-2188. PMID: 30112710.
      View in: PubMed
    6. Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13). PMID: 29997298.
      View in: PubMed
    7. Baek KI, Ding Y, Chang CC, Chang M, Sevag Packard RR, Hsu JJ, Fei P, Hsiai TK. Advanced microscopy to elucidate cardiovascular injury and regeneration: 4D light-sheet imaging. Prog Biophys Mol Biol. 2018 10; 138:105-115. PMID: 29752956.
      View in: PubMed
    8. Ding Y, Lee J, Hsu JJ, Chang CC, Baek KI, Ranjbarvaziri S, Ardehali R, Packard RRS, Hsiai TK. Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair. Curr Cardiol Rep. 2018 03 24; 20(5):35. PMID: 29574550.
      View in: PubMed
    9. Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat Commun. 2018 02 21; 9(1):754. PMID: 29467410.
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    10. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1203-H1213. PMID: 29451816.
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    11. Baek KI, Li R, Jen N, Choi H, Kaboodrangi A, Ping P, Liem D, Beebe T, Hsiai TK. Flow-Responsive Vascular Endothelial Growth Factor Receptor-Protein Kinase C Isoform Epsilon Signaling Mediates Glycolytic Metabolites for Vascular Repair. Antioxid Redox Signal. 2018 Jan 01; 28(1):31-43. PMID: 28762754.
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    12. Packard RRS, Baek KI, Beebe T, Jen N, Ding Y, Shi F, Fei P, Kang BJ, Chen PH, Gau J, Chen M, Tang JY, Shih YH, Ding Y, Li D, Xu X, Hsiai TK. Automated Segmentation of Light-Sheet Fluorescent Imaging to Characterize Experimental Doxorubicin-Induced Cardiac Injury and Repair. Sci Rep. 2017 08 17; 7(1):8603. PMID: 28819303.
      View in: PubMed
    13. Abiri P, Abiri A, Packard RRS, Ding Y, Yousefi A, Ma J, Bersohn M, Nguyen KL, Markovic D, Moloudi S, Hsiai TK. Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system. Sci Rep. 2017 07 21; 7(1):6180. PMID: 28733677.
      View in: PubMed
    14. Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics. 2017; 7(9):2431-2442. PMID: 28744325.
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    15. Lee J, Chou TC, Kang D, Kang H, Chen J, Baek KI, Wang W, Ding Y, Carlo DD, Tai YC, Hsiai TK. A Rapid Capillary-Pressure Driven Micro-Channel to Demonstrate Newtonian Fluid Behavior of Zebrafish Blood at High Shear Rates. Sci Rep. 2017 05 16; 7(1):1980. PMID: 28512313.
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    16. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res. 2017 04 14; 120(8):1240-1242. PMID: 28408452.
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    17. Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites. Sci Rep. 2017 02 17; 7:42906. PMID: 28211537.
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    18. Ding Y, Lee J, Ma J, Sung K, Yokota T, Singh N, Dooraghi M, Abiri P, Wang Y, Kulkarni RP, Nakano A, Nguyen TP, Fei P, Hsiai TK. Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution. Sci Rep. 2017 02 06; 7:42209. PMID: 28165052.
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    19. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A, Kulkarni RP. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping. Sci Rep. 2016 08 08; 6:30736. PMID: 27498769.
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    20. Lee J, Fei P, Sevag Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 08 01; 126(8):3158. PMID: 27479748.
      View in: PubMed
    21. Ma J, Luo Y, Sevag Packard RR, Ma T, Ding Y, Abiri P, Tai YC, Zhou Q, Shung KK, Li R, Hsiai T. Ultrasonic Transducer-Guided Electrochemical Impedance Spectroscopy to Assess Lipid-Laden Plaques. Sens Actuators B Chem. 2016 Nov 01; 235:154-161. PMID: 27773967.
      View in: PubMed
    22. Lee J, Fei P, Packard RR, Kang H, Xu H, Baek KI, Jen N, Chen J, Yen H, Kuo CC, Chi NC, Ho CM, Li R, Hsiai TK. 4-Dimensional light-sheet microscopy to elucidate shear stress modulation of cardiac trabeculation. J Clin Invest. 2016 05 02; 126(5):1679-90. PMID: 27018592.
      View in: PubMed
    23. Fei P, Lee J, Packard RR, Sereti KI, Xu H, Ma J, Ding Y, Kang H, Chen H, Sung K, Kulkarni R, Ardehali R, Kuo CC, Xu X, Ho CM, Hsiai TK. Cardiac Light-Sheet Fluorescent Microscopy for Multi-Scale and Rapid Imaging of Architecture and Function. Sci Rep. 2016 Mar 03; 6:22489. PMID: 26935567.
      View in: PubMed
    24. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 09; 44(9):2695-706. PMID: 26857007.
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    25. Guan Z, Lee J, Jiang H, Dong S, Jen N, Hsiai T, Ho CM, Fei P. Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope. Biomed Opt Express. 2016 Jan 01; 7(1):194-208. PMID: 26819828.
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    26. Lee J, Packard RR, Hsiai TK. Blood flow modulation of vascular dynamics. Curr Opin Lipidol. 2015 Oct; 26(5):376-83. PMID: 26218416.
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    27. Ma T, Zhou B, Hsiai TK, Shung KK. A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging: The Synergistic Approach to Characterizing Vulnerable Plaques. Ultrason Imaging. 2016 09; 38(5):314-31. PMID: 26400676.
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    28. Li R, Jen N, Wu L, Lee J, Fang K, Quigley K, Lee K, Wang S, Zhou B, Vergnes L, Chen YR, Li Z, Reue K, Ann DK, Hsiai TK. Disturbed Flow Induces Autophagy, but Impairs Autophagic Flux to Perturb Mitochondrial Homeostasis. Antioxid Redox Signal. 2015 Nov 20; 23(15):1207-19. PMID: 26120766.
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    29. Lee J, Cao H, Kang BJ, Jen N, Yu F, Lee CA, Fei P, Park J, Bohlool S, Lash-Rosenberg L, Shung KK, Hsiai TK. Hemodynamics and ventricular function in a zebrafish model of injury and repair. Zebrafish. 2014 Oct; 11(5):447-54. PMID: 25237983.
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    30. Li R, Navab K, Hough G, Daher N, Zhang M, Mittelstein D, Lee K, Pakbin P, Saffari A, Bhetraratana M, Sulaiman D, Beebe T, Wu L, Jen N, Wine E, Tseng CH, Araujo JA, Fogelman A, Sioutas C, Navab M, Hsiai TK. Effect of exposure to atmospheric ultrafine particles on production of free fatty acids and lipid metabolites in the mouse small intestine. Environ Health Perspect. 2015 Jan; 123(1):34-41. PMID: 25170928.
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    31. Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK. Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos. Arterioscler Thromb Vasc Biol. 2014 Oct; 34(10):2268-75. PMID: 25147335.
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    32. Cao H, Yu F, Zhao Y, Zhang X, Tai J, Lee J, Darehzereshki A, Bersohn M, Lien CL, Chi NC, Tai YC, Hsiai TK. Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium. Integr Biol (Camb). 2014 Aug; 6(8):789-95. PMID: 24945366.
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    33. Hsiai T, Li S, Bursac N. Introduction to the special issue on tissue engineering and regenerative medicine. Ann Biomed Eng. 2014 Jul; 42(7):1355-6. PMID: 24923380.
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    34. Dickover M, Hegarty JM, Ly K, Lopez D, Yang H, Zhang R, Tedeschi N, Hsiai TK, Chi NC. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev Biol. 2014 May 15; 389(2):182-91. PMID: 24607366.
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    35. Cao H, Yu F, Zhao Y, Scianmarello N, Lee J, Dai W, Jen N, Beebe T, Li R, Ebrahimi R, Chang DS, Mody FV, Pacella J, Tai YC, Hsiai T. Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits. Biosens Bioelectron. 2014 Apr 15; 54:610-6. PMID: 24333932.
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    36. Lee J, Moghadam ME, Kung E, Cao H, Beebe T, Miller Y, Roman BL, Lien CL, Chi NC, Marsden AL, Hsiai TK. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis. PLoS One. 2013; 8(8):e72924. PMID: 24009714.
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    37. Du Y, Navab M, Shen M, Hill J, Pakbin P, Sioutas C, Hsiai TK, Li R. Ambient ultrafine particles reduce endothelial nitric oxide production via S-glutathionylation of eNOS. Biochem Biophys Res Commun. 2013 Jul 05; 436(3):462-6. PMID: 23751346.
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    38. Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T. Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice. J Lipid Res. 2013 Jun; 54(6):1608-15. PMID: 23564731.
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    39. Yu F, Lee J, Jen N, Li X, Zhang Q, Tang R, Zhou Q, Kim ES, Hsiai TK. Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions. Biosens Bioelectron. 2013 May 15; 43:237-44. PMID: 23318546.
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    40. Li R, Mittelstein D, Kam W, Pakbin P, Du Y, Tintut Y, Navab M, Sioutas C, Hsiai T. Atmospheric ultrafine particles promote vascular calcification via the NF-?B signaling pathway. Am J Physiol Cell Physiol. 2013 Feb 15; 304(4):C362-9. PMID: 23242187.
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    41. Jen N, Yu F, Lee J, Wasmund S, Dai X, Chen C, Chawareeyawong P, Yang Y, Li R, Hamdan MH, Hsiai TK. Atrial fibrillation pacing decreases intravascular shear stress in a New Zealand white rabbit model: implications in endothelial function. Biomech Model Mechanobiol. 2013 Aug; 12(4):735-45. PMID: 22983703.
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    42. Yu F, Zhao Y, Gu J, Quigley KL, Chi NC, Tai YC, Hsiai TK. Flexible microelectrode arrays to interface epicardial electrical signals with intracardial calcium transients in zebrafish hearts. Biomed Microdevices. 2012 Apr; 14(2):357-66. PMID: 22124886.
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    43. Li R, Mittelstein D, Fang K, Beebe T, Quigley K, Berliner J, Hsiai TK. Angiopoeitin-2 modulates Survivin expression in OxLDL-induced endothelial cell apoptosis. Biochem Biophys Res Commun. 2012 Jan 06; 417(1):619-22. PMID: 22182412.
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    44. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases. Am J Physiol Cell Physiol. 2012 Feb 15; 302(4):C658-65. PMID: 22031601.
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    45. Li R, Jen N, Yu F, Hsiai TK. Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress. Curr Protoc Cytom. 2011 Oct; Chapter 9:Unit9.37. PMID: 21965108.
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    46. Yu F, Dai X, Beebe T, Hsiai T. Electrochemical impedance spectroscopy to characterize inflammatory atherosclerotic plaques. Biosens Bioelectron. 2011 Dec 15; 30(1):165-73. PMID: 21959227.
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    47. Takabe W, Jen N, Ai L, Hamilton R, Wang S, Holmes K, Dharbandi F, Khalsa B, Bressler S, Barr ML, Li R, Hsiai TK. Oscillatory shear stress induces mitochondrial superoxide production: implication of NADPH oxidase and c-Jun NH2-terminal kinase signaling. Antioxid Redox Signal. 2011 Sep 01; 15(5):1379-88. PMID: 20919940.
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    48. Yu F, Ai L, Dai W, Rozengurt N, Yu H, Hsiai TK. MEMS thermal sensors to detect changes in heat transfer in the pre-atherosclerotic regions of fat-fed New Zealand white rabbits. Ann Biomed Eng. 2011 Jun; 39(6):1736-44. PMID: 21380571.
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    49. Yu F, Huang J, Adlerz K, Jadvar H, Hamdan MH, Chi N, Chen JN, Hsiai TK. Evolving cardiac conduction phenotypes in developing zebrafish larvae: implications to drug sensitivity. Zebrafish. 2010 Dec; 7(4):325-31. PMID: 20958244.
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    50. Yu F, Li R, Ai L, Edington C, Yu H, Barr M, Kim ES, Hsiai TK. Electrochemical impedance spectroscopy to assess vascular oxidative stress. Ann Biomed Eng. 2011 Jan; 39(1):287-96. PMID: 20652746.
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    51. Ai L, Zhang L, Dai W, Hu C, Shung KK, Hsiai TK. Real-time assessment of flow reversal in an eccentric arterial stenotic model. J Biomech. 2010 Oct 19; 43(14):2678-83. PMID: 20655537.
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    52. Li R, Ning Z, Cui J, Yu F, Sioutas C, Hsiai T. Diesel exhaust particles modulate vascular endothelial cell permeability: implication of ZO-1 expression. Toxicol Lett. 2010 Sep 01; 197(3):163-8. PMID: 20576493.
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    53. Li R, Ning Z, Majumdar R, Cui J, Takabe W, Jen N, Sioutas C, Hsiai T. Ultrafine particles from diesel vehicle emissions at different driving cycles induce differential vascular pro-inflammatory responses: implication of chemical components and NF-kappaB signaling. Part Fibre Toxicol. 2010 Mar 22; 7:6. PMID: 20307321.
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    54. Yu F, Li R, Parks E, Takabe W, Hsiai TK. Electrocardiogram signals to assess zebrafish heart regeneration: implication of long QT intervals. Ann Biomed Eng. 2010 Jul; 38(7):2346-57. PMID: 20221900.
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    55. Takabe W, Li R, Ai L, Yu F, Berliner JA, Hsiai TK. Oxidized low-density lipoprotein-activated c-Jun NH2-terminal kinase regulates manganese superoxide dismutase ubiquitination: implication for mitochondrial redox status and apoptosis. Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):436-41. PMID: 20139358.
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    56. Li R, Beebe T, Cui J, Rouhanizadeh M, Ai L, Wang P, Gundersen M, Takabe W, Hsiai TK. Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):406-12. PMID: 19666009.
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    57. Ai L, Yu H, Dai W, Hale SL, Kloner RA, Hsiai TK. Real-time intravascular shear stress in the rabbit abdominal aorta. IEEE Trans Biomed Eng. 2009 Jun; 56(6):1755-64. PMID: 19527952.
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    58. Ai L, Yu H, Takabe W, Paraboschi A, Yu F, Kim ES, Li R, Hsiai TK. Optimization of intravascular shear stress assessment in vivo. J Biomech. 2009 Jul 22; 42(10):1429-37. PMID: 19457490.
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    59. Sun P, Zhang Y, Yu F, Parks E, Lyman A, Wu Q, Ai L, Hu CH, Zhou Q, Shung K, Lien CL, Hsiai TK. Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart. Ann Biomed Eng. 2009 May; 37(5):890-901. PMID: 19280341.
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    60. Ai L, Hsiai TK. Spatial mapping of real-time quantitative shear stress with vascular oxidative stress. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:6557-9. PMID: 19964904.
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    61. Li R, Ning Z, Cui J, Khalsa B, Ai L, Takabe W, Beebe T, Majumdar R, Sioutas C, Hsiai T. Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation. Free Radic Biol Med. 2009 Mar 15; 46(6):775-82. PMID: 19154785.
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    62. Hsiai TK, Wu JC. Hemodynamic forces regulate embryonic stem cell commitment to vascular progenitors. Curr Cardiol Rev. 2008 Nov; 4(4):269-74. PMID: 20066134.
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    63. Hamilton RT, Asatryan L, Nilsen JT, Isas JM, Gallaher TK, Sawamura T, Hsiai TK. LDL protein nitration: implication for LDL protein unfolding. Arch Biochem Biophys. 2008 Nov 01; 479(1):1-14. PMID: 18713619.
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    64. Ai L, Rouhanizadeh M, Wu JC, Takabe W, Yu H, Alavi M, Li R, Chu Y, Miller J, Heistad DD, Hsiai TK. Shear stress influences spatial variations in vascular Mn-SOD expression: implication for LDL nitration. Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1576-85. PMID: 18434620.
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    65. Rouhanizadeh M, Takabe W, Ai L, Yu H, Hsiai T. Monitoring oxidative stress in vascular endothelial cells in response to fluid shear stress: from biochemical analyses to micro- and nanotechnologies. Methods Enzymol. 2008; 441:111-50. PMID: 18554532.
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    66. Hsiai T, Berliner JA. Oxidative stress as a regulator of murine atherosclerosis. Curr Drug Targets. 2007 Dec; 8(12):1222-9. PMID: 18220699.
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    67. Hsiai TK, Hwang J, Barr ML, Correa A, Hamilton R, Alavi M, Rouhanizadeh M, Cadenas E, Hazen SL. Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med. 2007 Feb 15; 42(4):519-29. PMID: 17275684.
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    68. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. Mechanical response of a calcified plaque model to fluid shear force. Ann Biomed Eng. 2006 Oct; 34(10):1535-41. PMID: 17006755.
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    69. Hwang J, Rouhanizadeh M, Hamilton RT, Lin TC, Eiserich JP, Hodis HN, Hsiai TK. 17beta-Estradiol reverses shear-stress-mediated low density lipoprotein modifications. Free Radic Biol Med. 2006 Aug 15; 41(4):568-78. PMID: 16863990.
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    70. Hwang J, Hodis HN, Hsiai TK, Asatryan L, Sevanian A. Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins. Atherosclerosis. 2006 Nov; 189(1):76-82. PMID: 16386257.
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    71. Rouhanizadeh M, Lin TC, Arcas D, Hwang J, Hsiai TK. Spatial variations in shear stress in a 3-D bifurcation model at low Reynolds numbers. Ann Biomed Eng. 2005 Oct; 33(10):1360-74. PMID: 16240085.
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    72. DeMaio L, Rouhanizadeh M, Reddy S, Sevanian A, Hwang J, Hsiai TK. Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H674-83. PMID: 16172163.
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    73. Rouhanizadeh M, Hwang J, Clempus RE, Marcu L, Lassègue B, Sevanian A, Hsiai TK. Oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine induces vascular endothelial superoxide production: implication of NADPH oxidase. Free Radic Biol Med. 2005 Dec 01; 39(11):1512-22. PMID: 16274886.
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    74. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses. Ann Biomed Eng. 2004 Feb; 32(2):189-201. PMID: 15008367.
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    75. Rouhanizadeh M, Tang T, Li C, DeMaio L, Zhou C, Hsiai T. Detection of oxidized low density lipoproteins by indium oxide nanowires-based field effect transistor. Conf Proc IEEE Eng Med Biol Soc. 2004; 2006:204-7. PMID: 17271645.
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    76. Soundararajan G, Hsiai TK, DeMaio L, Chang M, Chang S. MEMS shear stress sensors for cardiovascular diagnostics. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:2420-3. PMID: 17270760.
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    77. Hwang J, Ing MH, Salazar A, Lassègue B, Griendling K, Navab M, Sevanian A, Hsiai TK. Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Circ Res. 2003 Dec 12; 93(12):1225-32. PMID: 14593003.
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    78. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003 Sep; 17(12):1648-57. PMID: 12958171.
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    79. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt). Ann Biomed Eng. 2002 May; 30(5):646-56. PMID: 12108839.
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