Xinjiang Cai

Title(s)HS Assistant Clinical Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0001-8933-7133 Additional info
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    Collapse Biography 
    Collapse education and training
    University of California, Los Angeles, Los Angeles, CA09/2022Cardiology Fellowship (STAR program)
    Icahn School of Medicine at Mount Sinai (VA), Bronx, NY06/2018Internal Medicine Residency
    Collapse awards and honors
    National Heart, Lung, and Blood Institute2023  - 2028K08: Mentored Clinical Scientist Development Award
    University of California, Los Angeles2019  - 2023Tibor Fabian Research Award
    University of California, Los Angeles2019  - 2022T32 Cardiovascular Scientist Training Program
    University of California, Los Angeles2019Fellow-in-training Travel Award, American College of Cardiology
    Icahn School of Medicine at Mount Sinai2017PAGNY Research Day Award for an outstanding research presentation
    Duke University Medical Center2007  - 2009American Heart Association Postdoctoral Fellowship Award

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2024 Sep 17; 13(18):e037114. Cai X, White Q, Wang DR, DeFilippi CR, Bertoni AG, Wu CO, Liu K, Lima JAC, Budoff MJ, Fonarow GC, Watson KE, McClelland RL, Yang EH. PMID: 39235461; PMCID: PMC11935614.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models. J Clin Invest. 2024 May 23; 134(15). Zhao Y, Wu X, Yang Y, Zhang L, Cai X, Chen S, Vera A, Ji J, Boström KI, Yao Y. PMID: 38781032; PMCID: PMC11290970.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification. JCI Insight. 2024 Mar 08; 9(5). Zhao Y, Yang Y, Wu X, Zhang L, Cai X, Ji J, Chen S, Vera A, Boström KI, Yao Y. PMID: 38456502; PMCID: PMC10972591.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Two-step regulation by matrix Gla protein in brown adipose cell differentiation. Mol Metab. 2024 Feb; 80:101870. Zhang L, Cai X, Ma F, Qiao X, Ji J, Ma JA, Vergnes L, Zhao Y, Yao Y, Wu X, Boström KI. PMID: 38184275; PMCID: PMC10832489.
      View in: PubMed   Mentions:    Fields:    
    5. Aurora Kinase A Regulates Cell Transitions in Glucocorticoid-Induced Bone Loss. Cells. 2023 10 11; 12(20). Qiao X, Yang Y, Zhao Y, Wu X, Zhang L, Cai X, Ji J, Boström KI, Yao Y. PMID: 37887278; PMCID: PMC10605378.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. GSK3β Inhibition Ameliorates Atherosclerotic Calcification. Int J Mol Sci. 2023 Jul 19; 24(14). Cai X, Zhao Y, Yang Y, Wu X, Zhang L, Ma JA, Ji J, Boström KI, Yao Y. PMID: 37511396; PMCID: PMC10380320.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    7. Cell Transitions Contribute to Glucocorticoid-Induced Bone Loss. Cells. 2023 07 08; 12(14). Qiao X, Wu X, Zhao Y, Yang Y, Zhang L, Cai X, Ma JA, Ji J, Lyons K, Boström KI, Yao Y. PMID: 37508475; PMCID: PMC10377921.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Regulating the cell shift of endothelial cell-like myofibroblasts in pulmonary fibrosis. Eur Respir J. 2023 06; 61(6). Wu X, Zhang D, Qiao X, Zhang L, Cai X, Ji J, Ma JA, Zhao Y, Belperio JA, Boström KI, Yao Y. PMID: 36758986; PMCID: PMC10249020.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    9. GSK3β Inhibition Reduced Vascular Calcification in Ins2Akita/+ Mice. Int J Mol Sci. 2023 Mar 22; 24(6). Boström KI, Qiao X, Zhao Y, Wu X, Zhang L, Ma JA, Ji J, Cai X, Yao Y. PMID: 36983045; PMCID: PMC10054481.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    10. A Potential New Link Between Inflammation and Vascular Calcification. J Am Heart Assoc. 2023 01 03; 12(1):e028358. Cai X, Tintut Y, Demer LL. PMID: 36537336; PMCID: PMC9973574.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Single-Cell RNA-Seq Identifies Dynamic Cardiac Transition Program from ADCs Induced by Leukemia Inhibitory Factor. Stem Cells. 2022 10 21; 40(10):932-948. Yao J, Ma F, Zhang L, Zhu C, Jumabay M, Yao Z, Wang L, Cai X, Zhang D, Qiao X, Shivkumar K, Pellegrini M, Yao Y, Wu X, Boström KI. PMID: 35896368; PMCID: PMC9585902.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. Resistin and risks of incident heart failure subtypes and cardiac fibrosis: the Multi-Ethnic Study of Atherosclerosis. ESC Heart Fail. 2022 10; 9(5):3452-3460. Cai X, Allison MA, Ambale-Venkatesh B, Jorgensen NW, Lima JAC, Muse ED, McClelland RL, Shea S, Lebeche D. PMID: 35860859; PMCID: PMC9715803.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    13. Ascending Aortic Pseudoaneurysm: A Rare Complication of Transcatheter Aortic Valve Replacement and Thoracic Surgery. Circ Cardiovasc Imaging. 2022 07; 15(7):e014076. Cai X, Shahandeh N, Ji J, Finn JP, Fishbein GA, Biniwale RM, Ardehali A, Sayah DM, Yang EH. PMID: 35861982; PMCID: PMC9304754.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. NAADP-binding proteins find their identity. Trends Biochem Sci. 2022 03; 47(3):235-249. Marchant JS, Gunaratne GS, Cai X, Slama JT, Patel S. PMID: 34810081; PMCID: PMC8840967.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    15. A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii. Nat Commun. 2021 10 04; 12(1):5802. Li ZH, King TP, Ayong L, Asady B, Cai X, Rahman T, Vella SA, Coppens I, Patel S, Moreno SNJ. PMID: 34608145; PMCID: PMC8490419.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    16. Shifting osteogenesis in vascular calcification. JCI Insight. 2021 05 24; 6(10). Yao J, Wu X, Qiao X, Zhang D, Zhang L, Ma JA, Cai X, Boström KI, Yao Y. PMID: 33848269; PMCID: PMC8262274.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    17. Pronethalol Reduces Sox2 (SRY [Sex-Determining Region Y]-Box 2) to Ameliorate Vascular Calcification. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):931-933. Zhang D, Qiao X, Yao J, Zhang L, Wu X, Ma J, Cai X, Bostrom KI, Yao Y. PMID: 33297753; PMCID: PMC8105260.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. Pronethalol decreases RBPJκ to reduce Sox2 in cerebral arteriovenous malformation. Vasc Med. 2020 12; 25(6):569-571. Qiao X, Zhang D, Zhang L, Yao J, Wu X, Cai X, Boström KI, Yao Y. PMID: 32833597; PMCID: PMC8034816.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Cardiac sympathetic innervation and arrhythmogenesis. J Physiol. 2019 09; 597(17):4445-4446. Cai X, Huang L. PMID: 31348525; PMCID: PMC6716989.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. Intact parathyroid hormone levels and primary hyperparathyroidism. Endocr Res. 2017 Aug; 42(3):241-245. Al-Hraishawi H, Dellatore PJ, Cai X, Wang X. PMID: 28318329.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. Elife. 2017 02 23; 6. Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE. PMID: 28226241; PMCID: PMC5362262.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    22. IMPACT OF ETHNIC BACKGROUND ON CLINICAL CHARACTERISTICS AND CARDIOVASCULAR RISK FACTORS AMONG PATIENTS WITH PRIMARY HYPERPARATHYROIDISM. Endocr Pract. 2016 Mar; 22(3):323-7. Hu S, Cai X, Mewani V, Wong B, Trooskin S, Wang X. PMID: 26536140.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Evolution of acidic Ca²⁺ stores and their resident Ca²⁺-permeable channels. Cell Calcium. 2015 Mar; 57(3):222-30. Patel S, Cai X. PMID: 25591931.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    24. Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view. Cell Calcium. 2015 Mar; 57(3):166-73. Cai X, Wang X, Patel S, Clapham DE. PMID: 25498309; PMCID: PMC4355082.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    25. Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Sci Signal. 2014 Nov 18; 7(352):ra109. Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S. PMID: 25406377; PMCID: PMC4327855.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    26. Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex. Mol Biol Evol. 2014 Oct; 31(10):2735-40. Cai X, Wang X, Clapham DE. PMID: 25063443; PMCID: PMC4169769.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    27. Regulation of the epithelial Ca²⁺ channel TRPV5 by reversible histidine phosphorylation mediated by NDPK-B and PHPT1. Mol Biol Cell. 2014 Apr; 25(8):1244-50. Cai X, Srivastava S, Surindran S, Li Z, Skolnik EY. PMID: 24523290; PMCID: PMC3982990.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    28. Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells. Mol Cell Biol. 2012 Aug; 32(15):3132-9. Srivastava S, Cai X, Li Z, Sun Y, Skolnik EY. PMID: 22645315; PMCID: PMC3434511.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    29. Evolutionary genomics reveals the premetazoan origin of opposite gating polarity in animal-type voltage-gated ion channels. Genomics. 2012 Apr; 99(4):241-5. Cai X. PMID: 22326743.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    30. Ancient origin of four-domain voltage-gated Na+ channels predates the divergence of animals and fungi. J Membr Biol. 2012 Feb; 245(2):117-23. Cai X. PMID: 22258316.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    31. Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20072-7. Cai X, Srivastava S, Sun Y, Li Z, Wu H, Zuvela-Jelaska L, Li J, Salamon RS, Backer JM, Skolnik EY. PMID: 22128329; PMCID: PMC3250182.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    32. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):308-16. Wu JH, Zhang L, Fanaroff AC, Cai X, Sharma KC, Brian L, Exum ST, Shenoy SK, Peppel K, Freedman NJ. PMID: 22095977; PMCID: PMC3321515.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    33. P2X receptor homologs in basal fungi. Purinergic Signal. 2012 Mar; 8(1):11-3. Cai X. PMID: 21887491; PMCID: PMC3286542.
      View in: PubMed   Mentions: 9     Fields:    
    34. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. Mol Biol Evol. 2012 Jan; 29(1):91-100. Cai X, Clapham DE. PMID: 21680871; PMCID: PMC4037924.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    35. Degeneration of an intracellular ion channel in the primate lineage by relaxation of selective constraints. Mol Biol Evol. 2010 Oct; 27(10):2352-9. Cai X, Patel S. PMID: 20463046.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem. 2010 Jan 29; 285(5):2897-901. Brailoiu E, Hooper R, Cai X, Brailoiu GC, Keebler MV, Dun NJ, Marchant JS, Patel S. PMID: 19940116; PMCID: PMC2823445.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    37. Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol. 2009 Jul 27; 186(2):201-9. Brailoiu E, Churamani D, Cai X, Schrlau MG, Brailoiu GC, Gao X, Hooper R, Boulware MJ, Dun NJ, Marchant JS, Patel S. PMID: 19620632; PMCID: PMC2717647.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    38. Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis. Mol Pharmacol. 2009 Mar; 75(3):626-36. Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ. PMID: 19092051; PMCID: PMC2684914.
      View in: PubMed   Mentions: 8     Fields:    
    39. A new tr(i)p to sense pain: TRPA1 channel as a target for novel analgesics. Expert Rev Neurother. 2008 Nov; 8(11):1675-81. Cai X. PMID: 18986238.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    40. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. PLoS One. 2008; 3(10):e3569. Cai X, Clapham DE. PMID: 18974790; PMCID: PMC2572835.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    41. Unicellular Ca2+ signaling 'toolkit' at the origin of metazoa. Mol Biol Evol. 2008 Jul; 25(7):1357-61. Cai X. PMID: 18385221.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    42. Subunit stoichiometry and channel pore structure of ion channels: all for one, or one for one? J Physiol. 2008 Feb 15; 586(4):925-6. Cai X. PMID: 18079155; PMCID: PMC2375647.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Molecular evolution and functional divergence of the Ca(2+) sensor protein in store-operated Ca(2+) entry: stromal interaction molecule. PLoS One. 2007 Jul 11; 2(7):e609. Cai X. PMID: 17622354; PMCID: PMC1904252.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    44. Molecular evolution and structural analysis of the Ca(2+) release-activated Ca(2+) channel subunit, Orai. J Mol Biol. 2007 May 18; 368(5):1284-91. Cai X. PMID: 17400243.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    45. Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies. Expert Rev Cardiovasc Ther. 2006 Nov; 4(6):789-800. Cai X. PMID: 17173496.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    46. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. J Biol Chem. 2006 Dec 08; 281(49):37758-72. Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ. PMID: 17018529.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    47. New therapeutic possibilities for vein graft disease in the post-edifoligide era. Future Cardiol. 2006 Jul; 2(4):493-501. Cai X, Freedman NJ. PMID: 19804184.
      View in: PubMed   Mentions: 4     Fields:    
    48. Molecular evolution of the ankyrin gene family. Mol Biol Evol. 2006 Mar; 23(3):550-8. Cai X, Zhang Y. PMID: 16280541.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    49. The cation/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications. Mol Biol Evol. 2004 Sep; 21(9):1692-703. Cai X, Lytton J. PMID: 15163769.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    50. Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6. J Biol Chem. 2004 Feb 13; 279(7):5867-76. Cai X, Lytton J. PMID: 14625281.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    51. Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2. Ann N Y Acad Sci. 2002 Nov; 976:90-3. Cai X, Zhang K, Lytton J. PMID: 12502542.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    52. A novel topology and redox regulation of the rat brain K+-dependent Na+/Ca2+ exchanger, NCKX2. J Biol Chem. 2002 Dec 13; 277(50):48923-30. Cai X, Zhang K, Lytton J. PMID: 12377762.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    53. Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. J Biol Chem. 2001 Jun 22; 276(25):23161-72. Kraev A, Quednau BD, Leach S, Li XF, Dong H, Winkfein R, Perizzolo M, Cai X, Yang R, Philipson KD, Lytton J. PMID: 11294880.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
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