Linda L Demer

Title(s)Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0002-9618-6895 Additional info
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    Title(s)Professor, Physiology


    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins, Baltimore, MDMD,PhD06/1983Medicine, Bioengineering
    Collapse Awards and Honors
    1993Stein-Oppenheimer Award
    Royal College of Physicians2001Davidson Memorial Lectureship
    2002Franklin D. Murphy Research Prz
    American Heart Association2003Jeffrey Hoeg Award
    Temple University2007Steward Niewiarowski Award
    Gordon Research Conference2009Chair

    Collapse Overview 
    Collapse Overview
    Dr. Demer pioneered the field of research in cardiovascular calcification, studying its mechanisms at the level of cellular, molecular and biomechanical regulation. Her research group overcame dogma by demonstrating that bone and marrow form in human arteries, often in association with atherosclerosis, and that the process is both regulated by bone differentiation factors and related to embryonic skeletal development. They developed the first tissue culture model of vascular calcification, isolated and cloned the cells responsible for producing calcium mineral, and identified the regulatory molecules controlling the re-differentiation of vascular cells into osteooblastic cells. Her group is currently addressing the conundrum that coronary calcification is associated with increased risk of cardiovascular events, while it also progresses most rapidly in patients using statin drugs (which are associated with reduced risk), and it is more prevalent in elite endurance athletes, which is also associated with reduced risk. Using microCT and microPET imaging, her group is exploring the possibility that structural differences in the calcium mineral deposits affect whether they prevent or promote cardiac events.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification
    NIH R01HL151391Jan 1, 2021 - Dec 31, 2024
    Role: Principal Investigator
    The University of California - Los Angeles (UCLA) Resident Scientist Training Program (RSTP)
    NIH R38HL143614Mar 1, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Serotonin receptor contribution to inflammation-induced calcific aortic valve disease
    NIH R01HL137647Apr 1, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Does aging transform calcific vasculopathy into a plaque stabilizing process?
    NIH R21AG061586Jan 15, 2019 - Nov 30, 2021
    Role: Principal Investigator
    Mechanisms of intermittent parathyroid hormone effects on calcific aortic disease
    NIH R01HL121019Mar 15, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Role of Inhibitory SMADs in Calcific Aortic Valve Disease
    NIH R01HL114709Aug 23, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Role of Lymphatic Clearance in Lipid-Induced Calcific Vasculopathy and Bone Loss
    NIH R21HL109628Aug 1, 2011 - Jun 30, 2014
    Role: Principal Investigator
    RANKL/OPG-Mediated Control of Vascular Calcification
    NIH R01HL081202May 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Lipid Regulation of Vascular and Bone Osteoclastogenesis
    NIH R01HL069261Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator
    Cardiovascular Scientist Training Program
    NIH T32HL007895Jul 1, 1998 - Jun 30, 2024
    Role: Principal Investigator
    MECHANICAL BASIS FOR OPTIMAL BALLOON ANGIOPLASTY
    NIH R29HL043379Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    A METHOD FOR MONITORING BALLOON ANGIO- AND VALVULOPLASTY
    NIH R03RR004320Jul 1, 1988 - Dec 31, 1989
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Effects of LP533401 on vascular and bone calcification in hyperlipidemic mice. Biochem Biophys Res Commun. 2024 Mar 31; 710:149854. Pradhan S, Hon A, Xia Y, Kalanski S, Safvati N, Lu M, Demer LL, Tintut Y. PMID: 38581947.
      View in: PubMed   Mentions:
    2. Effects of activity levels on aortic calcification in hyperlipidemic mice as measured by microPETmicroCT. Atherosclerosis. 2023 09; 380:117198. Hon A, Hsu JJ, Zambrano A, Xia Y, Lu M, Echeverri D, Kalanski S, Umar S, Demer LL, Tintut Y. PMID: 37579593.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Potential mechanisms linking high-volume exercise with coronary artery calcification. Heart. 2023 07 12; 109(15):1139-1145. Zambrano A, Tintut Y, Demer LL, Hsu JJ. PMID: 36702539; PMCID: PMC10356745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. A Potential New Link Between Inflammation and Vascular Calcification. J Am Heart Assoc. 2023 01 03; 12(1):e028358. Cai X, Tintut Y, Demer LL. PMID: 36537336; PMCID: PMC9973574.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Regulation of cardiovascular calcification by lipids and lipoproteins. Curr Opin Lipidol. 2022 10 01; 33(5):289-294. Hsu JJ, Tintut Y, Demer LL. PMID: 35979985; PMCID: PMC9474571.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Microarchitectural Changes of Cardiovascular Calcification in Response to In Vivo Interventions Using Deep-Learning Segmentation and Computed Tomography Radiomics. Arterioscler Thromb Vasc Biol. 2022 08; 42(8):e228-e241. Patel NR, Setya K, Pradhan S, Lu M, Demer LL, Tintut Y. PMID: 35708025; PMCID: PMC9339530.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    7. Biomolecules Orchestrating Cardiovascular Calcification. Biomolecules. 2021 10 07; 11(10). Tintut Y, Honda HM, Demer LL. PMID: 34680115; PMCID: PMC8533507.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Lipids and cardiovascular calcification: contributions to plaque vulnerability. Curr Opin Lipidol. 2021 10 01; 32(5):308-314. Hsu JJ, Tintut Y, Demer LL. PMID: 34320564; PMCID: PMC8416796.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. A biomarker for vascular calcification: shedding light on an unfinished story? Cardiovasc Res. 2021 07 07; 117(8):1809-1810. Hsu JJ, Tintut Y, Demer LL. PMID: 33751037; PMCID: PMC8262638.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Hearts of Stone: Calcific Aortic Stenosis and Antiresorptive Agents for Osteoporosis. Circulation. 2021 06 22; 143(25):2428-2430. Demer LL, Tintut Y. PMID: 34152795; PMCID: PMC8221117.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Potential impact of the steroid hormone, vitamin D, on the vasculature. Am Heart J. 2021 09; 239:147-153. Tintut Y, Demer LL. PMID: 34051171; PMCID: PMC8425762.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    12. Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice. Arterioscler Thromb Vasc Biol. 2021 04; 41(4):e185-e192. Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y. PMID: 33472400; PMCID: PMC7990692.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    13. Serotonin receptor type 2B activation augments TNF-α-induced matrix mineralization in murine valvular interstitial cells. J Cell Biochem. 2021 02; 122(2):249-258. Fong F, Xian J, Demer LL, Tintut Y. PMID: 32901992; PMCID: PMC7770058.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2020 06 21; 41(24):2313-2330. Borén J, Chapman MJ, Krauss RM, Packard CJ, Bentzon JF, Binder CJ, Daemen MJ, Demer LL, Hegele RA, Nicholls SJ, Nordestgaard BG, Watts GF, Bruckert E, Fazio S, Ference BA, Graham I, Horton JD, Landmesser U, Laufs U, Masana L, Pasterkamp G, Raal FJ, Ray KK, Schunkert H, Taskinen MR, van de Sluis B, Wiklund O, Tokgozoglu L, Catapano AL, Ginsberg HN. PMID: 32052833; PMCID: PMC7308544.
      View in: PubMed   Mentions: 352     Fields:    Translation:Humans
    15. Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice. J Nucl Cardiol. 2021 10; 28(5):2207-2214. Hsu JJ, Fong F, Patel R, Qiao R, Lo K, Soundia A, Chang CC, Le V, Tseng CH, Demer LL, Tintut Y. PMID: 31897996; PMCID: PMC7329622.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    16. Regulation of calcific vascular and valvular disease by nuclear receptors. Curr Opin Lipidol. 2019 10; 30(5):357-363. Sallam T, Tintut Y, Demer LL. PMID: 31369409; PMCID: PMC6719701.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease. Trends Endocrinol Metab. 2019 09; 30(9):646-657. Demer LL, Tintut Y. PMID: 31279666; PMCID: PMC6708492.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    18. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. JCI Insight. 2019 04 11; 5. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. PMID: 30973827; PMCID: PMC6542601.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    19. Training the physician-scientist: views from program directors and aspiring young investigators. JCI Insight. 2018 12 06; 3(23). Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. PMID: 30518696; PMCID: PMC6328016.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    20. Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges. Front Cardiovasc Med. 2018; 5:172. Tintut Y, Hsu JJ, Demer LL. PMID: 30533416; PMCID: PMC6265366.
      View in: PubMed   Mentions: 17  
    21. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. PMID: 30135307; PMCID: PMC6141183.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    22. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13). Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. PMID: 29997298; PMCID: PMC6124527.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    23. Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. Circ Res. 2018 05 25; 122(11):1576-1585. Demer LL, Hsu JJ, Tintut Y. PMID: 29798901; PMCID: PMC6122607.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    24. The Autism Spectrum: Human Rights Perspectives. Pediatrics. 2018 04; 141(Suppl 4):S369-S372. Demer LL. PMID: 29610419.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1203-H1213. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. PMID: 29451816; PMCID: PMC6032086.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    26. Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res. 2017 04 14; 120(8):1240-1242. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. PMID: 28408452; PMCID: PMC5407390.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    27. Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification. Heart. 2016 11 01; 102(21):1710-1715. Hsu JJ, Lim J, Tintut Y, Demer LL. PMID: 27406839; PMCID: PMC5069068.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. COMP-lex Mechanics: Matricrine Signaling. Circ Res. 2016 07 08; 119(2):184-6. Tintut Y, Demer LL. PMID: 27390328; PMCID: PMC4940136.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    29. Reply: Evolutionary approach sheds light on the significance of vascular calcification. Trends Cardiovasc Med. 2017 01; 27(1):72. Demer LL, Tintut Y. PMID: 27499040; PMCID: PMC5167644.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    30. Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis. Am J Pathol. 2016 09; 186(9):2378-89. Lim J, Ehsanipour A, Hsu JJ, Lu J, Pedego T, Wu A, Walthers CM, Demer LL, Seidlits SK, Tintut Y. PMID: 27392969; PMCID: PMC5012467.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 09; 44(9):2695-706. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. PMID: 26857007; PMCID: PMC5403741.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    32. Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship. J Grad Med Educ. 2016 Feb; 8(1):85-90. Wong MD, Guerrero L, Sallam T, Frank JS, Fogelman AM, Demer LL. PMID: 26913109; PMCID: PMC4763397.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    33. Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification. J Cell Biochem. 2015 Oct; 116(10):2354-64. Li X, Lim J, Lu J, Pedego TM, Demer L, Tintut Y. PMID: 25864564; PMCID: PMC5003537.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    34. Exosomes: nanosized cellular messages. Circ Res. 2015 Apr 10; 116(8):1281-3. Tintut Y, Demer LL. PMID: 25858057; PMCID: PMC5127443.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Conflicting forces of warfarin and matrix gla protein in the artery wall. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):9-10. Demer LL, Boström KI. PMID: 25520520; PMCID: PMC4274625.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    36. The leading edge of vascular calcification. Trends Cardiovasc Med. 2015 May; 25(4):275-7. Demer LL, Tintut Y. PMID: 25572012; PMCID: PMC4414923.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Nov; 34(11):2387-93. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. PMID: 25189570; PMCID: PMC4199903.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansCells
    38. Inflammatory, metabolic, and genetic mechanisms of vascular calcification. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):715-23. Demer LL, Tintut Y. PMID: 24665125; PMCID: PMC3975044.
      View in: PubMed   Mentions: 127     Fields:    
    39. FGF23 protein expression in coronary arteries is associated with impaired kidney function. Nephrol Dial Transplant. 2014 Aug; 29(8):1525-32. van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K. PMID: 24459137; PMCID: PMC4118139.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    40. Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts. J Cell Biochem. 2014 Jan; 115(1):179-88. Li X, Garcia J, Lu J, Iriana S, Kalajzic I, Rowe D, Demer LL, Tintut Y. PMID: 24038594; PMCID: PMC3889484.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    41. Effects of bioactive lipids and lipoproteins on bone. Trends Endocrinol Metab. 2014 Feb; 25(2):53-9. Tintut Y, Demer LL. PMID: 24183940; PMCID: PMC3946677.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    42. Introduction to the Compendium on calcific aortic valve disease. Circ Res. 2013 Jul 05; 113(2):176-8. Heistad DD, Shanahan C, Demer LL. PMID: 23833291; PMCID: PMC4086797.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    43. Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):19-24. Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y. PMID: 23291186; PMCID: PMC3563775.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    44. Regulatory circuits controlling vascular cell calcification. Cell Mol Life Sci. 2013 Sep; 70(17):3187-97. Sallam T, Cheng H, Demer LL, Tintut Y. PMID: 23269436; PMCID: PMC3638052.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    45. Preferred mitotic orientation in pattern formation by vascular mesenchymal cells. Am J Physiol Heart Circ Physiol. 2012 Dec 15; 303(12):H1411-7. Wong MN, Nguyen TP, Chen TH, Hsu JJ, Zeng X, Saw A, Demer EM, Zhao X, Tintut Y, Demer LL. PMID: 23064835; PMCID: PMC3532532.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    46. Enhanced mineralization potential of vascular cells from SM22α-Rankl (tg) mice. Calcif Tissue Int. 2012 Dec; 91(6):379-86. Morony S, Sage AP, Corbin T, Lu J, Tintut Y, Demer LL. PMID: 23052229; PMCID: PMC3523707.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    47. Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells. Biomaterials. 2012 Dec; 33(35):9019-26. Chen TH, Zhu X, Pan L, Zeng X, Garfinkel A, Tintut Y, Demer LL, Zhao X, Ho CM. PMID: 23010575; PMCID: PMC3466383.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    48. Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells. J Vasc Res. 2012; 49(5):441-6. Cheng H, Reddy A, Sage A, Lu J, Garfinkel A, Tintut Y, Demer LL. PMID: 22797747; PMCID: PMC3478883.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. Patterns of periodic holes created by increased cell motility. Interface Focus. 2012 Aug 06; 2(4):457-64. Chen TH, Guo C, Zhao X, Yao Y, Boström KI, Wong MN, Tintut Y, Demer LL, Ho CM, Garfinkel A. PMID: 22649581; PMCID: PMC3363038.
      View in: PubMed   Mentions: 5  
    50. Adverse effects of hyperlipidemia on bone regeneration and strength. J Bone Miner Res. 2012 Feb; 27(2):309-18. Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, Tetradis S, Demer L, Aghaloo T, Tintut Y. PMID: 21987408; PMCID: PMC3274629.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    51. Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics. Circ Res. 2012 Feb 17; 110(4):551-9. Chen TH, Hsu JJ, Zhao X, Guo C, Wong MN, Huang Y, Li Z, Garfinkel A, Ho CM, Tintut Y, Demer LL. PMID: 22223355; PMCID: PMC3288887.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    52. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases. Am J Physiol Cell Physiol. 2012 Feb 15; 302(4):C658-65. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. PMID: 22031601; PMCID: PMC3287359.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    53. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 2011 Oct 18; 124(16):1783-91. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. PMID: 22007101; PMCID: PMC3306614.
      View in: PubMed   Mentions: 320     Fields:    Translation:Humans
    54. Role of cellular cholesterol metabolism in vascular cell calcification. J Biol Chem. 2011 Sep 23; 286(38):33701-6. Geng Y, Hsu JJ, Lu J, Ting TC, Miyazaki M, Demer LL, Tintut Y. PMID: 21835914; PMCID: PMC3190941.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    55. The roles of lipid oxidation products and receptor activator of nuclear factor-κB signaling in atherosclerotic calcification. Circ Res. 2011 Jun 10; 108(12):1482-93. Demer L, Tintut Y. PMID: 21659652; PMCID: PMC3128471.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    56. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res. 2011 Jun; 26(6):1197-206. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y. PMID: 21611962; PMCID: PMC3312754.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    57. Thematic series on the pathobiology of vascular calcification: an introduction. Circ Res. 2011 May 27; 108(11):1378-80. Towler DA, Demer LL. PMID: 21617134; PMCID: PMC4408081.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    58. Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. J Biol Chem. 2011 Jul 08; 286(27):23938-49. Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M. PMID: 21596756; PMCID: PMC3129175.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    59. The hemosteoblast: friend or foe? Circ Res. 2011 Apr 29; 108(9):1038-9. Tintut Y, Demer L. PMID: 21527740; PMCID: PMC3099550.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    60. Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler Thromb Vasc Biol. 2011 Jun; 31(6):1387-96. Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y. PMID: 21454810; PMCID: PMC3098301.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    61. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int. 2011 Feb; 79(4):414-22. Sage AP, Lu J, Tintut Y, Demer LL. PMID: 20944546; PMCID: PMC3198856.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    62. PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. J Biol Chem. 2010 Sep 24; 285(39):29925-31. Tseng W, Graham LS, Geng Y, Reddy A, Lu J, Effros RB, Demer L, Tintut Y. PMID: 20663885; PMCID: PMC2943298.
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    63. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol. 2010 Sep; 7(9):528-36. Sage AP, Tintut Y, Demer LL. PMID: 20664518; PMCID: PMC3014092.
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    64. The bone-vascular axis in chronic kidney disease. Curr Opin Nephrol Hypertens. 2010 Jul; 19(4):349-53. Demer L, Tintut Y. PMID: 20508522; PMCID: PMC3001327.
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    65. Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids. J Lipid Res. 2010 May; 51(5):1010-6. Tseng W, Lu J, Bishop GA, Watson AD, Sage AP, Demer L, Tintut Y. PMID: 19965598; PMCID: PMC2853427.
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    66. Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss. Clin Immunol. 2009 Nov; 133(2):265-75. Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB. PMID: 19699688; PMCID: PMC2805272.
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    67. Mechanisms linking osteoporosis with cardiovascular calcification. Curr Osteoporos Rep. 2009 Jul; 7(2):42-6. Demer LL, Tintut Y. PMID: 19631027; PMCID: PMC4422187.
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    68. Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H802-10. Hoshino T, Chow LA, Hsu JJ, Perlowski AA, Abedin M, Tobis J, Tintut Y, Mal AK, Klug WS, Demer LL. PMID: 19542489; PMCID: PMC2724207.
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    69. Systems biology of vascular calcification. Trends Cardiovasc Med. 2009 May; 19(4):118-23. Sage A, Tintut Y, Garfinkel A, Demer L. PMID: 19818947; PMCID: PMC2824648.
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    70. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification. FEBS Lett. 2009 Apr 17; 583(8):1344-8. Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. PMID: 19327357; PMCID: PMC2692939.
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    71. Nanoscale architecture in atherosclerotic calcification. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):1882-4. Demer LL, Sage AP, Tintut Y. PMID: 18946051; PMCID: PMC4426492.
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    72. Hyperlipidemia impairs osteoanabolic effects of PTH. J Bone Miner Res. 2008 Oct; 23(10):1672-9. Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y. PMID: 18505371; PMCID: PMC2576281.
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    73. Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):553-8. Huang MS, Sage AP, Lu J, Demer LL, Tintut Y. PMID: 18655772; PMCID: PMC2570192.
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    74. Vitamin D and osteogenic differentiation in the artery wall. Clin J Am Soc Nephrol. 2008 Sep; 3(5):1542-7. Hsu JJ, Tintut Y, Demer LL. PMID: 18562594; PMCID: PMC4571147.
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    75. Vascular calcification: pathobiology of a multifaceted disease. Circulation. 2008 Jun 03; 117(22):2938-48. Demer LL, Tintut Y. PMID: 18519861; PMCID: PMC4431628.
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    76. Murine models of atherosclerotic calcification. Curr Drug Targets. 2008 Mar; 9(3):224-8. Hsu JJ, Tintut Y, Demer LL. PMID: 18336241.
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    77. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation. 2008 Jan 22; 117(3):411-20. Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL. PMID: 18172035; PMCID: PMC2680735.
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    78. A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells". Free Radic Biol Med. 2008 Feb 15; 44(4):504-5. Demer LL, Tintut Y. PMID: 18005672.
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    79. Vascular calcification. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):346. Tintut Y, Huang M, Lu J, Tseng W, Garfinkel A, Demer LL. PMID: 18094506.
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    80. Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts. J Biol Chem. 2007 Jul 20; 282(29):21237-43. Huang MS, Morony S, Lu J, Zhang Z, Bezouglaia O, Tseng W, Tetradis S, Demer LL, Tintut Y. PMID: 17522049; PMCID: PMC3001330.
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    81. Mineralocorticoid receptor activation promotes vascular cell calcification. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):799-805. Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. PMID: 17234727.
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    82. Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification. J Investig Med. 2006 Nov; 54(7):395-401. Tintut Y, Demer L. PMID: 17169261.
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    83. Mechanical response of a calcified plaque model to fluid shear force. Ann Biomed Eng. 2006 Oct; 34(10):1535-41. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. PMID: 17006755.
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    84. Pitting phosphate transport inhibitors against vascular calcification. Circ Res. 2006 Apr 14; 98(7):857-9. Demer LL, Tintut Y. PMID: 16614308.
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    85. N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. Circ Res. 2006 Mar 31; 98(6):727-9. Abedin M, Lim J, Tang TB, Park D, Demer LL, Tintut Y. PMID: 16514067.
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    86. Regulation of RANKL-induced osteoclastic differentiation by vascular cells. J Mol Cell Cardiol. 2005 Aug; 39(2):389-93. Tintut Y, Abedin M, Cho J, Choe A, Lim J, Demer LL. PMID: 15893766.
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    87. Return to ectopia: stem cells in the artery wall. Arterioscler Thromb Vasc Biol. 2005 Jul; 25(7):1307-8. Demer LL, Tintut Y. PMID: 15980267.
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    88. Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways. Circ Res. 2005 Mar 04; 96(4):398-400. Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y. PMID: 15692088.
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    89. Skeleton key to vascular disease. J Am Coll Cardiol. 2004 Nov 16; 44(10):1977-9. Demer LL, Abedin M. PMID: 15542279.
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    90. Mesenchymal stem cells and the artery wall. Circ Res. 2004 Oct 01; 95(7):671-6. Abedin M, Tintut Y, Demer LL. PMID: 15459088.
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    91. Pattern formation by vascular mesenchymal cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9247-50. Garfinkel A, Tintut Y, Petrasek D, Boström K, Demer LL. PMID: 15197273; PMCID: PMC438961.
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    92. Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1161-70. Abedin M, Tintut Y, Demer LL. PMID: 15155384.
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    93. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses. Ann Biomed Eng. 2004 Feb; 32(2):189-201. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. PMID: 15008367.
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    94. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):e6-10. Tintut Y, Morony S, Demer LL. PMID: 14670933.
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    95. Multilineage potential of cells from the artery wall. Circulation. 2003 Nov 18; 108(20):2505-10. Tintut Y, Alfonso Z, Saini T, Radcliff K, Watson K, Boström K, Demer LL. PMID: 14581408.
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    96. Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1739-43. Demer LL, Tintut Y. PMID: 12958041.
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    97. Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003 Sep; 17(12):1648-57. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. PMID: 12958171; PMCID: PMC4108745.
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    98. Vascular calcification and its relation to bone calcification: possible underlying mechanisms. J Nucl Cardiol. 2003 Mar-Apr; 10(2):177-83. Mody N, Tintut Y, Radcliff K, Demer LL. PMID: 12673183.
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    99. Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids. Int J Epidemiol. 2002 Aug; 31(4):737-41. Demer LL. PMID: 12177011.
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    100. Novel mechanisms in accelerated vascular calcification in renal disease patients. Curr Opin Nephrol Hypertens. 2002 Jul; 11(4):437-43. Demer LL, Tintut Y, Parhami F. PMID: 12105395.
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    101. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt). Ann Biomed Eng. 2002 May; 30(5):646-56. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. PMID: 12108839.
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    102. Adipose rex: fat and fats that rule differentiation. Circ Res. 2002 Feb 22; 90(3):241-3. Demer LL. PMID: 11861408.
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    103. Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol. 2001 Nov; 21(11):1770-6. Hsiai TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM. PMID: 11701464.
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    104. Cholesterol in vascular and valvular calcification. Circulation. 2001 Oct 16; 104(16):1881-3. Demer LL. PMID: 11602487.
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    105. Recent advances in multifactorial regulation of vascular calcification. Curr Opin Lipidol. 2001 Oct; 12(5):555-60. Tintut Y, Demer LL. PMID: 11561176.
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    106. Placental calcification: a metastatic process? Placenta. 2001 Jul; 22(6):591-6. Poggi SH, Bostrom KI, Demer LL, Skinner HC, Koos BJ. PMID: 11440548.
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    107. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ Res. 2001 May 11; 88(9):954-60. Parhami F, Tintut Y, Ballard A, Fogelman AM, Demer LL. PMID: 11349006.
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    108. Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells. J Biol Chem. 2001 Apr 27; 276(17):14044-52. Boström K, Tsao D, Shen S, Wang Y, Demer LL. PMID: 11278388.
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    109. Regulation of vascular calcification in atherosclerosis. Z Kardiol. 2001; 90 Suppl 3:27-30. Parhami F, Tintut Y, Patel JK, Mody N, Hemmat A, Demer LL. PMID: 11374029.
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    110. Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res. 2001 Jan; 16(1):182-8. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL. PMID: 11149483.
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    111. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation. 2000 Nov 21; 102(21):2636-42. Tintut Y, Patel J, Parhami F, Demer LL. PMID: 11085968.
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    112. Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol. 2000 Nov; 20(11):2346-8. Parhami F, Garfinkel A, Demer LL. PMID: 11073836.
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    113. HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells. J Cell Biochem. 2000 May; 78(2):210-21. Boström K, Tintut Y, Kao SC, Stanford WP, Demer LL. PMID: 10842316.
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    114. Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts. FEBS Lett. 2000 Apr 07; 471(1):119-24. Jackson SM, Demer LL. PMID: 10760525.
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    115. Regulatory mechanisms in vascular calcification. Crit Rev Eukaryot Gene Expr. 2000; 10(2):151-8. Boström K, Demer LL. PMID: 11186330.
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    116. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res. 1999 Dec; 14(12):2067-78. Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M, Demer LL. PMID: 10620066.
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    117. Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation. J Biol Chem. 1999 Oct 08; 274(41):28875-9. Tintut Y, Parhami F, Le V, Karsenty G, Demer LL. PMID: 10506130.
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    118. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler Thromb Vasc Biol. 1999 Sep; 19(9):2094-104. Jackson SM, Parhami F, Xi XP, Berliner JA, Hsueh WA, Law RE, Demer LL. PMID: 10479650.
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    119. Osteopontin. Between a rock and a hard plaque. Circ Res. 1999 Feb 05; 84(2):250-2. Demer LL, Tintut Y. PMID: 9933258.
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    120. Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory. Arterioscler Thromb Vasc Biol. 1998 Dec; 18(12):1964-71. Watson KE, Parhami F, Shin V, Demer LL. PMID: 9848891.
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    121. cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification. J Biol Chem. 1998 Mar 27; 273(13):7547-53. Tintut Y, Parhami F, Boström K, Jackson SM, Demer LL. PMID: 9516456.
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    122. Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids? Curr Opin Lipidol. 1997 Oct; 8(5):312-4. Parhami F, Demer LL. PMID: 9335955.
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    123. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997 Sep 16; 96(6):1755-60. Watson KE, Abrolat ML, Malone LL, Hoeg JM, Doherty T, Detrano R, Demer LL. PMID: 9323058.
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    124. Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography. Circulation. 1997 Sep 02; 96(5):1477-81. Doherty TM, Tang W, Dascalos S, Watson KE, Demer LL, Shavelle RM, Detrano RC. PMID: 9315534.
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    125. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol. 1997 Apr; 17(4):680-7. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL. PMID: 9108780.
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    126. Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol. Circulation. 1997 Apr 01; 95(7):1954-60. Balica M, Boström K, Shin V, Tillisch K, Demer LL. PMID: 9107185.
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    127. Lipid hypothesis of cardiovascular calcification. Circulation. 1997 Jan 21; 95(2):297-8. Demer LL. PMID: 9008435.
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    128. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol. 1996 Jul; 16(7):831-42. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. PMID: 8673557.
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    129. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest. 1996 May 01; 97(9):2130-8. Uyemura K, Demer LL, Castle SC, Jullien D, Berliner JA, Gately MK, Warrier RR, Pham N, Fogelman AM, Modlin RL. PMID: 8621803; PMCID: PMC507288.
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    130. The atherosclerosis-calcification link? Curr Opin Lipidol. 1996 Apr; 7(2):101-4. Watson KE, Demer LL. PMID: 8743903.
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    131. Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers. Cell Calcium. 1996 Feb; 19(2):97-104. Honda HM, Goldhaber JI, Demer LL, Weiss JN. PMID: 8689675.
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    132. Role of molecular regulation in vascular calcification. J Atheroscler Thromb. 1996; 3(2):90-4. Parhami F, Boström K, Watson K, Demer LL. PMID: 9226460.
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    133. Physician-scientists as missing persons. Association of Subspecialty Professors. J Investig Med. 1995 Dec; 43(6):534-42. Neilson EG, Ausiello D, Demer LL. PMID: 8605612.
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    134. Genetic determination of cartilaginous metaplasia in mouse aorta. Arterioscler Thromb Vasc Biol. 1995 Dec; 15(12):2265-72. Qiao JH, Fishbein MC, Demer LL, Lusis AJ. PMID: 7489252.
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    135. A skeleton in the atherosclerosis closet. Circulation. 1995 Oct 15; 92(8):2029-32. Demer LL. PMID: 7554176.
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    136. Pathogenesis of atherosclerosis. Am J Cardiol. 1995 Sep 28; 76(9):18C-23C. Navab M, Fogelman AM, Berliner JA, Territo MC, Demer LL, Frank JS, Watson AD, Edwards PA, Lusis AJ. PMID: 7572682.
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    137. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. 1995 May 01; 91(9):2488-96. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. PMID: 7729036.
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    138. Atherosclerotic calcification: relation to developmental osteogenesis. Am J Cardiol. 1995 Feb 23; 75(6):88B-91B. Boström K, Watson KE, Stanford WP, Demer LL. PMID: 7863982.
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    139. Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen. Arterioscler Thromb. 1994 Nov; 14(11):1808-14. Chang GJ, Woo P, Honda HM, Ignarro LJ, Young L, Berliner JA, Demer LL. PMID: 7947607.
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    140. Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification. Arterioscler Thromb. 1994 Sep; 14(9):1480-97. Qiao JH, Xie PZ, Fishbein MC, Kreuzer J, Drake TA, Demer LL, Lusis AJ. PMID: 8068611.
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    141. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 1994 May; 93(5):2106-13. Watson KE, Boström K, Ravindranath R, Lam T, Norton B, Demer LL. PMID: 8182141; PMCID: PMC294336.
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    142. Mechanism of calcification in atherosclerosis. Trends Cardiovasc Med. 1994 Jan-Feb; 4(1):45-9. Demer LL, Watson KE, Boström K. PMID: 21244909.
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    143. Mechanical stimulation induces intercellular calcium signaling in bovine aortic endothelial cells. Am J Physiol. 1993 Jun; 264(6 Pt 2):H2094-102. Demer LL, Wortham CM, Dirksen ER, Sanderson MJ. PMID: 8322938.
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    144. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993 Apr; 91(4):1800-9. Boström K, Watson KE, Horn S, Wortham C, Herman IM, Demer LL. PMID: 8473518; PMCID: PMC288161.
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    145. A new anti-inflammatory leucine derivative, NPC-15669, inhibits growth of cultured human aortic smooth muscle cells. Arterioscler Thromb. 1993 Mar; 13(3):360-6. Bennett RL, Navab M, Demer LL, Fogelman AM. PMID: 8443139.
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    146. Effect of calcification and formalin fixation on in vitro distensibility of human femoral arteries. Am Heart J. 1993 Feb; 125(2 Pt 1):344-9. Park JC, Siegel RJ, Demer LL. PMID: 8427126.
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    147. High intensity ultrasound increases distensibility of calcific atherosclerotic arteries. J Am Coll Cardiol. 1991 Nov 01; 18(5):1259-62. Demer LL, Ariani M, Siegel RJ. PMID: 1833429.
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    148. Metabolic and functional recovery of ischemic human myocardium after coronary angioplasty. J Am Coll Cardiol. 1991 Oct; 18(4):966-78. Nienaber CA, Brunken RC, Sherman CT, Yeatman LA, Gambhir SS, Krivokapich J, Demer LL, Ratib O, Child JS, Phelps ME, et al. PMID: 1894871.
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    149. Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice. Arterioscler Thromb. 1991 Jul-Aug; 11(4):947-57. Mehrabian M, Demer LL, Lusis AJ. PMID: 2065045.
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    150. Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation. Circulation. 1991 Jun; 83(6):2083-93. Demer LL. PMID: 2040058.
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    151. Minimally modified low density lipoprotein is biologically active in vivo in mice. J Clin Invest. 1991 Jun; 87(6):2253-7. Liao F, Berliner JA, Mehrabian M, Navab M, Demer LL, Lusis AJ, Fogelman AM. PMID: 2040705; PMCID: PMC296987.
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    152. Assessment of coronary artery disease severity by positron emission tomography. Comparison with quantitative arteriography in 193 patients. Circulation. 1989 Apr; 79(4):825-35. Demer LL, Gould KL, Goldstein RA, Kirkeeide RL, Mullani NA, Smalling RW, Nishikawa A, Merhige ME. PMID: 2784361.
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