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Demer Linda

Title(s)Professor, Medicine
Phone(310) 825-8811
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    Other Positions
    Title(s)Professor, Physiology

    Title(s)Professor, Bioengineering

    Title(s)Executive Director, UCLA Specialty Training and Advanced Research (STAR) Program

    Title(s)Executive Vice Chair, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Serotonin receptor contribution to inflammation-induced calcific aortic valve disease
    NIH/NHLBI R01HL137647Apr 1, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Does aging transform calcific vasculopathy into a plaque stabilizing process?
    NIH/NIA R21AG061586Jan 15, 2019 - Nov 30, 2020
    Role: Principal Investigator
    Mechanisms of intermittent parathyroid hormone effects on calcific aortic disease
    NIH/NHLBI R01HL121019Mar 15, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Role of Inhibitory SMADs in Calcific Aortic Valve Disease
    NIH/NHLBI R01HL114709Aug 23, 2012 - Jun 30, 2016
    Role: Principal Investigator
    Role of Lymphatic Clearance in Lipid-Induced Calcific Vasculopathy and Bone Loss
    NIH/NHLBI R21HL109628Aug 1, 2011 - Jun 30, 2014
    Role: Principal Investigator
    RANKL/OPG-Mediated Control of Vascular Calcification
    NIH/NHLBI R01HL081202May 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Lipid Regulation of Vascular and Bone Osteoclastogenesis
    NIH/NHLBI R01HL069261Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator
    MECHANICAL BASIS FOR OPTIMAL BALLOON ANGIOPLASTY
    NIH/NHLBI R29HL043379Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    A METHOD FOR MONITORING BALLOON ANGIO- AND VALVULOPLASTY
    NIH/NCRR R03RR004320Jul 1, 1988 - Dec 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hsu JJ, Fong F, Patel R, Qiao R, Lo K, Soundia A, Chang CC, Le V, Tseng CH, Demer LL, Tintut Y. Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice. J Nucl Cardiol. 2020 Jan 02. PMID: 31897996.
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    2. Sallam T, Tintut Y, Demer LL. Regulation of calcific vascular and valvular disease by nuclear receptors. Curr Opin Lipidol. 2019 Oct; 30(5):357-363. PMID: 31369409.
      View in: PubMed
    3. Demer LL, Tintut Y. Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease. Trends Endocrinol Metab. 2019 Sep; 30(9):646-657. PMID: 31279666.
      View in: PubMed
    4. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. JCI Insight. 2019 Apr 11; 5. PMID: 30973827.
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    5. Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. Training the physician-scientist: views from program directors and aspiring young investigators. JCI Insight. 2018 12 06; 3(23). PMID: 30518696.
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    6. Tintut Y, Hsu JJ, Demer LL. Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges. Front Cardiovasc Med. 2018; 5:172. PMID: 30533416.
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    7. Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). PMID: 30135307.
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    8. Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13). PMID: 29997298.
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    9. Demer LL, Hsu JJ, Tintut Y. Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. Circ Res. 2018 05 25; 122(11):1576-1585. PMID: 29798901.
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    10. Demer LL. The Autism Spectrum: Human Rights Perspectives. Pediatrics. 2018 04; 141(Suppl 4):S369-S372. PMID: 29610419.
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    11. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1203-H1213. PMID: 29451816.
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    12. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res. 2017 04 14; 120(8):1240-1242. PMID: 28408452.
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    13. Hsu JJ, Lim J, Tintut Y, Demer LL. Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification. Heart. 2016 11 01; 102(21):1710-1715. PMID: 27406839.
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    14. Tintut Y, Demer LL. COMP-lex Mechanics: Matricrine Signaling. Circ Res. 2016 07 08; 119(2):184-6. PMID: 27390328.
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    15. Demer LL, Tintut Y. Reply: Evolutionary approach sheds light on the significance of vascular calcification. Trends Cardiovasc Med. 2017 01; 27(1):72. PMID: 27499040.
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    16. Lim J, Ehsanipour A, Hsu JJ, Lu J, Pedego T, Wu A, Walthers CM, Demer LL, Seidlits SK, Tintut Y. Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis. Am J Pathol. 2016 09; 186(9):2378-89. PMID: 27392969.
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    17. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 09; 44(9):2695-706. PMID: 26857007.
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    18. Wong MD, Guerrero L, Sallam T, Frank JS, Fogelman AM, Demer LL. Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship. J Grad Med Educ. 2016 Feb; 8(1):85-90. PMID: 26913109.
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    19. Li X, Lim J, Lu J, Pedego TM, Demer L, Tintut Y. Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification. J Cell Biochem. 2015 Oct; 116(10):2354-64. PMID: 25864564.
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    20. Tintut Y, Demer LL. Exosomes: nanosized cellular messages. Circ Res. 2015 Apr 10; 116(8):1281-3. PMID: 25858057.
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    21. Demer LL, Boström KI. Conflicting forces of warfarin and matrix gla protein in the artery wall. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):9-10. PMID: 25520520.
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    22. Demer LL, Tintut Y. The leading edge of vascular calcification. Trends Cardiovasc Med. 2015 May; 25(4):275-7. PMID: 25572012.
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    23. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Nov; 34(11):2387-93. PMID: 25189570.
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    24. Demer LL, Tintut Y. Inflammatory, metabolic, and genetic mechanisms of vascular calcification. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):715-23. PMID: 24665125.
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    25. van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K. FGF23 protein expression in coronary arteries is associated with impaired kidney function. Nephrol Dial Transplant. 2014 Aug; 29(8):1525-32. PMID: 24459137.
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    26. Li X, Garcia J, Lu J, Iriana S, Kalajzic I, Rowe D, Demer LL, Tintut Y. Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts. J Cell Biochem. 2014 Jan; 115(1):179-88. PMID: 24038594.
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    27. Tintut Y, Demer LL. Effects of bioactive lipids and lipoproteins on bone. Trends Endocrinol Metab. 2014 Feb; 25(2):53-9. PMID: 24183940.
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    28. Heistad DD, Shanahan C, Demer LL. Introduction to the Compendium on calcific aortic valve disease. Circ Res. 2013 Jul 05; 113(2):176-8. PMID: 23833291.
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    29. Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y. Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):19-24. PMID: 23291186.
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    30. Sallam T, Cheng H, Demer LL, Tintut Y. Regulatory circuits controlling vascular cell calcification. Cell Mol Life Sci. 2013 Sep; 70(17):3187-97. PMID: 23269436.
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    31. Wong MN, Nguyen TP, Chen TH, Hsu JJ, Zeng X, Saw A, Demer EM, Zhao X, Tintut Y, Demer LL. Preferred mitotic orientation in pattern formation by vascular mesenchymal cells. Am J Physiol Heart Circ Physiol. 2012 Dec 15; 303(12):H1411-7. PMID: 23064835.
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    32. Morony S, Sage AP, Corbin T, Lu J, Tintut Y, Demer LL. Enhanced mineralization potential of vascular cells from SM22a-Rankl (tg) mice. Calcif Tissue Int. 2012 Dec; 91(6):379-86. PMID: 23052229.
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    33. Chen TH, Zhu X, Pan L, Zeng X, Garfinkel A, Tintut Y, Demer LL, Zhao X, Ho CM. Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells. Biomaterials. 2012 Dec; 33(35):9019-26. PMID: 23010575.
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    34. Cheng H, Reddy A, Sage A, Lu J, Garfinkel A, Tintut Y, Demer LL. Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells. J Vasc Res. 2012; 49(5):441-6. PMID: 22797747.
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    35. Chen TH, Guo C, Zhao X, Yao Y, Boström KI, Wong MN, Tintut Y, Demer LL, Ho CM, Garfinkel A. Patterns of periodic holes created by increased cell motility. Interface Focus. 2012 Aug 06; 2(4):457-64. PMID: 22649581.
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    36. Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, Tetradis S, Demer L, Aghaloo T, Tintut Y. Adverse effects of hyperlipidemia on bone regeneration and strength. J Bone Miner Res. 2012 Feb; 27(2):309-18. PMID: 21987408.
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    37. Chen TH, Hsu JJ, Zhao X, Guo C, Wong MN, Huang Y, Li Z, Garfinkel A, Ho CM, Tintut Y, Demer LL. Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics. Circ Res. 2012 Feb 17; 110(4):551-9. PMID: 22223355.
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    38. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases. Am J Physiol Cell Physiol. 2012 Feb 15; 302(4):C658-65. PMID: 22031601.
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    39. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 2011 Oct 18; 124(16):1783-91. PMID: 22007101.
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    40. Geng Y, Hsu JJ, Lu J, Ting TC, Miyazaki M, Demer LL, Tintut Y. Role of cellular cholesterol metabolism in vascular cell calcification. J Biol Chem. 2011 Sep 23; 286(38):33701-6. PMID: 21835914.
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    41. Demer L, Tintut Y. The roles of lipid oxidation products and receptor activator of nuclear factor-?B signaling in atherosclerotic calcification. Circ Res. 2011 Jun 10; 108(12):1482-93. PMID: 21659652.
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    42. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res. 2011 Jun; 26(6):1197-206. PMID: 21611962.
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    43. Towler DA, Demer LL. Thematic series on the pathobiology of vascular calcification: an introduction. Circ Res. 2011 May 27; 108(11):1378-80. PMID: 21617134.
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    44. Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M. Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. J Biol Chem. 2011 Jul 08; 286(27):23938-49. PMID: 21596756.
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    45. Tintut Y, Demer L. The hemosteoblast: friend or foe? Circ Res. 2011 Apr 29; 108(9):1038-9. PMID: 21527740.
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    46. Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y. Runx2-upregulated receptor activator of nuclear factor ?B ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler Thromb Vasc Biol. 2011 Jun; 31(6):1387-96. PMID: 21454810.
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    47. Sage AP, Lu J, Tintut Y, Demer LL. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int. 2011 Feb; 79(4):414-22. PMID: 20944546.
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    48. Tseng W, Graham LS, Geng Y, Reddy A, Lu J, Effros RB, Demer L, Tintut Y. PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. J Biol Chem. 2010 Sep 24; 285(39):29925-31. PMID: 20663885.
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    49. Sage AP, Tintut Y, Demer LL. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol. 2010 Sep; 7(9):528-36. PMID: 20664518.
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    50. Demer L, Tintut Y. The bone-vascular axis in chronic kidney disease. Curr Opin Nephrol Hypertens. 2010 Jul; 19(4):349-53. PMID: 20508522.
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    51. Tseng W, Lu J, Bishop GA, Watson AD, Sage AP, Demer L, Tintut Y. Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids. J Lipid Res. 2010 May; 51(5):1010-6. PMID: 19965598.
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    52. Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB. Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss. Clin Immunol. 2009 Nov; 133(2):265-75. PMID: 19699688.
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    53. Demer LL, Tintut Y. Mechanisms linking osteoporosis with cardiovascular calcification. Curr Osteoporos Rep. 2009 Jul; 7(2):42-6. PMID: 19631027.
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    54. Hoshino T, Chow LA, Hsu JJ, Perlowski AA, Abedin M, Tobis J, Tintut Y, Mal AK, Klug WS, Demer LL. Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H802-10. PMID: 19542489.
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    55. Sage A, Tintut Y, Garfinkel A, Demer L. Systems biology of vascular calcification. Trends Cardiovasc Med. 2009 May; 19(4):118-23. PMID: 19818947.
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    56. Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification. FEBS Lett. 2009 Apr 17; 583(8):1344-8. PMID: 19327357.
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    57. Demer LL, Sage AP, Tintut Y. Nanoscale architecture in atherosclerotic calcification. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):1882-4. PMID: 18946051.
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    58. Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y. Hyperlipidemia impairs osteoanabolic effects of PTH. J Bone Miner Res. 2008 Oct; 23(10):1672-9. PMID: 18505371.
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    59. Huang MS, Sage AP, Lu J, Demer LL, Tintut Y. Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):553-8. PMID: 18655772.
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    60. Hsu JJ, Tintut Y, Demer LL. Vitamin D and osteogenic differentiation in the artery wall. Clin J Am Soc Nephrol. 2008 Sep; 3(5):1542-7. PMID: 18562594.
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    61. Demer LL, Tintut Y. Vascular calcification: pathobiology of a multifaceted disease. Circulation. 2008 Jun 03; 117(22):2938-48. PMID: 18519861.
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    62. Hsu JJ, Tintut Y, Demer LL. Murine models of atherosclerotic calcification. Curr Drug Targets. 2008 Mar; 9(3):224-8. PMID: 18336241.
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    63. Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation. 2008 Jan 22; 117(3):411-20. PMID: 18172035.
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    64. Demer LL, Tintut Y. A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells". Free Radic Biol Med. 2008 Feb 15; 44(4):504-5. PMID: 18005672.
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    65. Tintut Y, Huang M, Lu J, Tseng W, Garfinkel A, Demer LL. Vascular calcification. J Musculoskelet Neuronal Interact. 2007 Oct-Dec; 7(4):346. PMID: 18094506.
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    66. Huang MS, Morony S, Lu J, Zhang Z, Bezouglaia O, Tseng W, Tetradis S, Demer LL, Tintut Y. Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts. J Biol Chem. 2007 Jul 20; 282(29):21237-43. PMID: 17522049.
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    67. Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. Mineralocorticoid receptor activation promotes vascular cell calcification. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):799-805. PMID: 17234727.
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    68. Tintut Y, Demer L. Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification. J Investig Med. 2006 Nov; 54(7):395-401. PMID: 17169261.
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    69. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. Mechanical response of a calcified plaque model to fluid shear force. Ann Biomed Eng. 2006 Oct; 34(10):1535-41. PMID: 17006755.
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    70. Demer LL, Tintut Y. Pitting phosphate transport inhibitors against vascular calcification. Circ Res. 2006 Apr 14; 98(7):857-9. PMID: 16614308.
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    71. Abedin M, Lim J, Tang TB, Park D, Demer LL, Tintut Y. N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. Circ Res. 2006 Mar 31; 98(6):727-9. PMID: 16514067.
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    72. Tintut Y, Abedin M, Cho J, Choe A, Lim J, Demer LL. Regulation of RANKL-induced osteoclastic differentiation by vascular cells. J Mol Cell Cardiol. 2005 Aug; 39(2):389-93. PMID: 15893766.
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    73. Demer LL, Tintut Y. Return to ectopia: stem cells in the artery wall. Arterioscler Thromb Vasc Biol. 2005 Jul; 25(7):1307-8. PMID: 15980267.
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    74. Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y. Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways. Circ Res. 2005 Mar 04; 96(4):398-400. PMID: 15692088.
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    75. Demer LL, Abedin M. Skeleton key to vascular disease. J Am Coll Cardiol. 2004 Nov 16; 44(10):1977-9. PMID: 15542279.
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    76. Abedin M, Tintut Y, Demer LL. Mesenchymal stem cells and the artery wall. Circ Res. 2004 Oct 01; 95(7):671-6. PMID: 15459088.
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    77. Garfinkel A, Tintut Y, Petrasek D, Boström K, Demer LL. Pattern formation by vascular mesenchymal cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9247-50. PMID: 15197273.
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    78. Abedin M, Tintut Y, Demer LL. Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1161-70. PMID: 15155384.
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    79. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses. Ann Biomed Eng. 2004 Feb; 32(2):189-201. PMID: 15008367.
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    80. Tintut Y, Morony S, Demer LL. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):e6-10. PMID: 14670933.
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    81. Tintut Y, Alfonso Z, Saini T, Radcliff K, Watson K, Boström K, Demer LL. Multilineage potential of cells from the artery wall. Circulation. 2003 Nov 18; 108(20):2505-10. PMID: 14581408.
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    82. Demer LL, Tintut Y. Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1739-43. PMID: 12958041.
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    83. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003 Sep; 17(12):1648-57. PMID: 12958171.
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    84. Mody N, Tintut Y, Radcliff K, Demer LL. Vascular calcification and its relation to bone calcification: possible underlying mechanisms. J Nucl Cardiol. 2003 Mar-Apr; 10(2):177-83. PMID: 12673183.
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    85. Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y, Demer LL. Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. J Bone Miner Res. 2002 Nov; 17(11):1997-2003. PMID: 12412807.
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    86. Parhami F, Basseri B, Hwang J, Tintut Y, Demer LL. High-density lipoprotein regulates calcification of vascular cells. Circ Res. 2002 Oct 04; 91(7):570-6. PMID: 12364384.
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    87. Demer LL. Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids. Int J Epidemiol. 2002 Aug; 31(4):737-41. PMID: 12177011.
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    88. Demer LL, Tintut Y, Parhami F. Novel mechanisms in accelerated vascular calcification in renal disease patients. Curr Opin Nephrol Hypertens. 2002 Jul; 11(4):437-43. PMID: 12105395.
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    89. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt). Ann Biomed Eng. 2002 May; 30(5):646-56. PMID: 12108839.
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    90. Demer LL. Adipose rex: fat and fats that rule differentiation. Circ Res. 2002 Feb 22; 90(3):241-3. PMID: 11861408.
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    91. Tintut Y, Patel J, Territo M, Saini T, Parhami F, Demer LL. Monocyte/macrophage regulation of vascular calcification in vitro. Circulation. 2002 Feb 05; 105(5):650-5. PMID: 11827934.
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    92. Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002 Apr 19; 277(16):14221-6. PMID: 11827970.
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    93. Hsiai TK, Cho SK, Reddy S, Hama S, Navab M, Demer LL, Honda HM, Ho CM. Pulsatile flow regulates monocyte adhesion to oxidized lipid-induced endothelial cells. Arterioscler Thromb Vasc Biol. 2001 Nov; 21(11):1770-6. PMID: 11701464.
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    94. Demer LL. Cholesterol in vascular and valvular calcification. Circulation. 2001 Oct 16; 104(16):1881-3. PMID: 11602487.
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    95. Demer LL. Boning up (or down) on statins. Arterioscler Thromb Vasc Biol. 2001 Oct; 21(10):1565-6. PMID: 11597926.
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    96. Tintut Y, Demer LL. Recent advances in multifactorial regulation of vascular calcification. Curr Opin Lipidol. 2001 Oct; 12(5):555-60. PMID: 11561176.
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    97. Honda HM, Hsiai T, Wortham CM, Chen M, Lin H, Navab M, Demer LL. A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells. Atherosclerosis. 2001 Oct; 158(2):385-90. PMID: 11583717.
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    98. Mody N, Parhami F, Sarafian TA, Demer LL. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med. 2001 Aug 15; 31(4):509-19. PMID: 11498284.
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    99. Poggi SH, Bostrom KI, Demer LL, Skinner HC, Koos BJ. Placental calcification: a metastatic process? Placenta. 2001 Jul; 22(6):591-6. PMID: 11440548.
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    100. Parhami F, Tintut Y, Ballard A, Fogelman AM, Demer LL. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ Res. 2001 May 11; 88(9):954-60. PMID: 11349006.
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    101. Boström K, Tsao D, Shen S, Wang Y, Demer LL. Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells. J Biol Chem. 2001 Apr 27; 276(17):14044-52. PMID: 11278388.
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    102. Parhami F, Tintut Y, Patel JK, Mody N, Hemmat A, Demer LL. Regulation of vascular calcification in atherosclerosis. Z Kardiol. 2001; 90 Suppl 3:27-30. PMID: 11374029.
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    103. Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL. Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res. 2001 Jan; 16(1):182-8. PMID: 11149483.
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    104. Tintut Y, Patel J, Parhami F, Demer LL. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation. 2000 Nov 21; 102(21):2636-42. PMID: 11085968.
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    105. Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol. 2000 Nov; 20(11):2346-8. PMID: 11073836.
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    106. Boström K, Tintut Y, Kao SC, Stanford WP, Demer LL. HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells. J Cell Biochem. 2000 May; 78(2):210-21. PMID: 10842316.
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    107. Jackson SM, Demer LL. Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts. FEBS Lett. 2000 Apr 07; 471(1):119-24. PMID: 10760525.
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    108. Boström K, Demer LL. Regulatory mechanisms in vascular calcification. Crit Rev Eukaryot Gene Expr. 2000; 10(2):151-8. PMID: 11186330.
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    109. Parhami F, Jackson SM, Tintut Y, Le V, Balucan JP, Territo M, Demer LL. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res. 1999 Dec; 14(12):2067-78. PMID: 10620066.
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    110. Tintut Y, Parhami F, Le V, Karsenty G, Demer LL. Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation. J Biol Chem. 1999 Oct 08; 274(41):28875-9. PMID: 10506130.
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    111. Jackson SM, Parhami F, Xi XP, Berliner JA, Hsueh WA, Law RE, Demer LL. Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler Thromb Vasc Biol. 1999 Sep; 19(9):2094-104. PMID: 10479650.
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    112. Demer LL, Tintut Y. Osteopontin. Between a rock and a hard plaque. Circ Res. 1999 Feb 05; 84(2):250-2. PMID: 9933258.
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    113. Watson KE, Parhami F, Shin V, Demer LL. Fibronectin and collagen I matrixes promote calcification of vascular cells in vitro, whereas collagen IV matrix is inhibitory. Arterioscler Thromb Vasc Biol. 1998 Dec; 18(12):1964-71. PMID: 9848891.
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    114. Tintut Y, Parhami F, Boström K, Jackson SM, Demer LL. cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification. J Biol Chem. 1998 Mar 27; 273(13):7547-53. PMID: 9516456.
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    115. Parhami F, Demer LL. Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids? Curr Opin Lipidol. 1997 Oct; 8(5):312-4. PMID: 9335955.
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    116. Watson KE, Abrolat ML, Malone LL, Hoeg JM, Doherty T, Detrano R, Demer LL. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997 Sep 16; 96(6):1755-60. PMID: 9323058.
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    117. Doherty TM, Tang W, Dascalos S, Watson KE, Demer LL, Shavelle RM, Detrano RC. Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography. Circulation. 1997 Sep 02; 96(5):1477-81. PMID: 9315534.
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    118. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol. 1997 Apr; 17(4):680-7. PMID: 9108780.
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    119. Balica M, Boström K, Shin V, Tillisch K, Demer LL. Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol. Circulation. 1997 Apr 01; 95(7):1954-60. PMID: 9107185.
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    120. Demer LL. Lipid hypothesis of cardiovascular calcification. Circulation. 1997 Jan 21; 95(2):297-8. PMID: 9008435.
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    121. Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol. 1996 Jul; 16(7):831-42. PMID: 8673557.
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    122. Uyemura K, Demer LL, Castle SC, Jullien D, Berliner JA, Gately MK, Warrier RR, Pham N, Fogelman AM, Modlin RL. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest. 1996 May 01; 97(9):2130-8. PMID: 8621803.
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    123. Watson KE, Demer LL. The atherosclerosis-calcification link? Curr Opin Lipidol. 1996 Apr; 7(2):101-4. PMID: 8743903.
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    124. Honda HM, Goldhaber JI, Demer LL, Weiss JN. Endothelium-dependent vasodilators do not cause propagated intercellular Ca2+ waves in vascular endothelial monolayers. Cell Calcium. 1996 Feb; 19(2):97-104. PMID: 8689675.
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    125. Parhami F, Boström K, Watson K, Demer LL. Role of molecular regulation in vascular calcification. J Atheroscler Thromb. 1996; 3(2):90-4. PMID: 9226460.
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    126. Qiao JH, Fishbein MC, Demer LL, Lusis AJ. Genetic determination of cartilaginous metaplasia in mouse aorta. Arterioscler Thromb Vasc Biol. 1995 Dec; 15(12):2265-72. PMID: 7489252.
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    127. Neilson EG, Ausiello D, Demer LL. Physician-scientists as missing persons. Association of Subspecialty Professors. J Investig Med. 1995 Dec; 43(6):534-42. PMID: 8605612.
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    128. Demer LL. A skeleton in the atherosclerosis closet. Circulation. 1995 Oct 15; 92(8):2029-32. PMID: 7554176.
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    129. Navab M, Fogelman AM, Berliner JA, Territo MC, Demer LL, Frank JS, Watson AD, Edwards PA, Lusis AJ. Pathogenesis of atherosclerosis. Am J Cardiol. 1995 Sep 28; 76(9):18C-23C. PMID: 7572682.
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    130. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. 1995 May 01; 91(9):2488-96. PMID: 7729036.
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    131. Boström K, Watson KE, Stanford WP, Demer LL. Atherosclerotic calcification: relation to developmental osteogenesis. Am J Cardiol. 1995 Feb 23; 75(6):88B-91B. PMID: 7863982.
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    132. Chang GJ, Woo P, Honda HM, Ignarro LJ, Young L, Berliner JA, Demer LL. Oxidation of LDL to a biologically active form by derivatives of nitric oxide and nitrite in the absence of superoxide. Dependence on pH and oxygen. Arterioscler Thromb. 1994 Nov; 14(11):1808-14. PMID: 7947607.
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    133. Qiao JH, Xie PZ, Fishbein MC, Kreuzer J, Drake TA, Demer LL, Lusis AJ. Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification. Arterioscler Thromb. 1994 Sep; 14(9):1480-97. PMID: 8068611.
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    134. Watson KE, Boström K, Ravindranath R, Lam T, Norton B, Demer LL. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 1994 May; 93(5):2106-13. PMID: 8182141.
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    135. Demer LL, Watson KE, Boström K. Mechanism of calcification in atherosclerosis. Trends Cardiovasc Med. 1994 Jan-Feb; 4(1):45-9. PMID: 21244909.
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    136. Demer LL, Wortham CM, Dirksen ER, Sanderson MJ. Mechanical stimulation induces intercellular calcium signaling in bovine aortic endothelial cells. Am J Physiol. 1993 Jun; 264(6 Pt 2):H2094-102. PMID: 8322938.
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    137. Boström K, Watson KE, Horn S, Wortham C, Herman IM, Demer LL. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest. 1993 Apr; 91(4):1800-9. PMID: 8473518.
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    138. Bennett RL, Navab M, Demer LL, Fogelman AM. A new anti-inflammatory leucine derivative, NPC-15669, inhibits growth of cultured human aortic smooth muscle cells. Arterioscler Thromb. 1993 Mar; 13(3):360-6. PMID: 8443139.
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    139. Park JC, Siegel RJ, Demer LL. Effect of calcification and formalin fixation on in vitro distensibility of human femoral arteries. Am Heart J. 1993 Feb; 125(2 Pt 1):344-9. PMID: 8427126.
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    140. Demer LL, Ariani M, Siegel RJ. High intensity ultrasound increases distensibility of calcific atherosclerotic arteries. J Am Coll Cardiol. 1991 Nov 01; 18(5):1259-62. PMID: 1833429.
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    141. Nienaber CA, Brunken RC, Sherman CT, Yeatman LA, Gambhir SS, Krivokapich J, Demer LL, Ratib O, Child JS, Phelps ME. Metabolic and functional recovery of ischemic human myocardium after coronary angioplasty. J Am Coll Cardiol. 1991 Oct; 18(4):966-78. PMID: 1894871.
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    142. Mehrabian M, Demer LL, Lusis AJ. Differential accumulation of intimal monocyte-macrophages relative to lipoproteins and lipofuscin corresponds to hemodynamic forces on cardiac valves in mice. Arterioscler Thromb. 1991 Jul-Aug; 11(4):947-57. PMID: 2065045.
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    143. Demer LL. Effect of calcification on in vivo mechanical response of rabbit arteries to balloon dilation. Circulation. 1991 Jun; 83(6):2083-93. PMID: 2040058.
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    144. Liao F, Berliner JA, Mehrabian M, Navab M, Demer LL, Lusis AJ, Fogelman AM. Minimally modified low density lipoprotein is biologically active in vivo in mice. J Clin Invest. 1991 Jun; 87(6):2253-7. PMID: 2040705.
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