Linda L Demer

Title(s)Professor, Medicine
SchoolMedicine
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    Other Positions
    Title(s)Professor, Physiology


    Collapse Research 
    Collapse Research Activities and Funding
    Role of intermittent activation of parathyroid hormone receptor in exercise-induced vascular calcification
    NIH R01HL151391Jan 1, 2021 - Dec 31, 2024
    Role: Principal Investigator
    The University of California - Los Angeles (UCLA) Resident Scientist Training Program (RSTP)
    NIH R38HL143614Mar 1, 2020 - Feb 29, 2024
    Role: Principal Investigator
    Serotonin receptor contribution to inflammation-induced calcific aortic valve disease
    NIH R01HL137647Apr 1, 2019 - Mar 31, 2023
    Role: Principal Investigator
    Does aging transform calcific vasculopathy into a plaque stabilizing process?
    NIH R21AG061586Jan 15, 2019 - Nov 30, 2021
    Role: Principal Investigator
    Mechanisms of intermittent parathyroid hormone effects on calcific aortic disease
    NIH R01HL121019Mar 15, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Role of Inhibitory SMADs in Calcific Aortic Valve Disease
    NIH R01HL114709Aug 23, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Role of Lymphatic Clearance in Lipid-Induced Calcific Vasculopathy and Bone Loss
    NIH R21HL109628Aug 1, 2011 - Jun 30, 2014
    Role: Principal Investigator
    RANKL/OPG-Mediated Control of Vascular Calcification
    NIH R01HL081202May 1, 2006 - Apr 30, 2012
    Role: Principal Investigator
    Lipid Regulation of Vascular and Bone Osteoclastogenesis
    NIH R01HL069261Sep 30, 2001 - Aug 31, 2005
    Role: Principal Investigator
    Cardiovascular Scientist Training Program
    NIH T32HL007895Jul 1, 1998 - Jun 30, 2024
    Role: Principal Investigator
    MECHANICAL BASIS FOR OPTIMAL BALLOON ANGIOPLASTY
    NIH R29HL043379Jul 1, 1989 - Jun 30, 1994
    Role: Principal Investigator
    A METHOD FOR MONITORING BALLOON ANGIO- AND VALVULOPLASTY
    NIH R03RR004320Jul 1, 1988 - Dec 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A biomarker for vascular calcification: shedding light on an unfinished story? Cardiovasc Res. 2021 Jul 07; 117(8):1809-1810. Hsu JJ, Tintut Y, Demer LL. PMID: 33751037.
      View in: PubMed   Mentions:    Fields:    
    2. Hearts of Stone: Calcific Aortic Stenosis and Antiresorptive Agents for Osteoporosis. Circulation. 2021 Jun 22; 143(25):2428-2430. Demer LL, Tintut Y. PMID: 34152795.
      View in: PubMed   Mentions:    Fields:    
    3. Potential Impact of the Steroid Hormone, Vitamin D, on the Vasculature Vitamin D-hormones and cardiovascular disease. Am Heart J. 2021 May 26. Tintut Y, Demer LL. PMID: 34051171.
      View in: PubMed   Mentions:    Fields:    
    4. Statin Effects on Vascular Calcification: Microarchitectural Changes in Aortic Calcium Deposits in Aged Hyperlipidemic Mice. Arterioscler Thromb Vasc Biol. 2021 04; 41(4):e185-e192. Xian JZ, Lu M, Fong F, Qiao R, Patel NR, Abeydeera D, Iriana S, Demer LL, Tintut Y. PMID: 33472400.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Serotonin receptor type 2B activation augments TNF-a-induced matrix mineralization in murine valvular interstitial cells. J Cell Biochem. 2021 Feb; 122(2):249-258. Fong F, Xian J, Demer LL, Tintut Y. PMID: 32901992.
      View in: PubMed   Mentions: 1     Fields:    
    6. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur Heart J. 2020 06 21; 41(24):2313-2330. Borén J, Chapman MJ, Krauss RM, Packard CJ, Bentzon JF, Binder CJ, Daemen MJ, Demer LL, Hegele RA, Nicholls SJ, Nordestgaard BG, Watts GF, Bruckert E, Fazio S, Ference BA, Graham I, Horton JD, Landmesser U, Laufs U, Masana L, Pasterkamp G, Raal FJ, Ray KK, Schunkert H, Taskinen MR, van de Sluis B, Wiklund O, Tokgozoglu L, Catapano AL, Ginsberg HN. PMID: 32052833.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    7. Changes in microarchitecture of atherosclerotic calcification assessed by 18F-NaF PET and CT after a progressive exercise regimen in hyperlipidemic mice. J Nucl Cardiol. 2020 Jan 02. Hsu JJ, Fong F, Patel R, Qiao R, Lo K, Soundia A, Chang CC, Le V, Tseng CH, Demer LL, Tintut Y. PMID: 31897996.
      View in: PubMed   Mentions: 7     Fields:    
    8. Regulation of calcific vascular and valvular disease by nuclear receptors. Curr Opin Lipidol. 2019 10; 30(5):357-363. Sallam T, Tintut Y, Demer LL. PMID: 31369409.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease. Trends Endocrinol Metab. 2019 09; 30(9):646-657. Demer LL, Tintut Y. PMID: 31279666.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. Contractile and hemodynamic forces coordinate Notch1b-mediated outflow tract valve formation. JCI Insight. 2019 04 11; 5. Hsu JJ, Vedula V, Baek KI, Chen C, Chen J, Chou MI, Lam J, Subhedar S, Wang J, Ding Y, Chang CC, Lee J, Demer LL, Tintut Y, Marsden AL, Hsiai TK. PMID: 30973827.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges. Front Cardiovasc Med. 2018; 5:172. Tintut Y, Hsu JJ, Demer LL. PMID: 30533416.
      View in: PubMed   Mentions:
    12. Multiscale light-sheet for rapid imaging of cardiopulmonary system. JCI Insight. 2018 08 23; 3(16). Ding Y, Ma J, Langenbacher AD, Baek KI, Lee J, Chang CC, Hsu JJ, Kulkarni RP, Belperio J, Shi W, Ranjbarvaziri S, Ardehali R, Tintut Y, Demer LL, Chen JN, Fei P, Packard RRS, Hsiai TK. PMID: 30135307.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    13. Spatial and temporal variations in hemodynamic forces initiate cardiac trabeculation. JCI Insight. 2018 07 12; 3(13). Lee J, Vedula V, Baek KI, Chen J, Hsu JJ, Ding Y, Chang CC, Kang H, Small A, Fei P, Chuong CM, Li R, Demer L, Packard RRS, Marsden AL, Hsiai TK. PMID: 29997298.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. Circ Res. 2018 05 25; 122(11):1576-1585. Demer LL, Hsu JJ, Tintut Y. PMID: 29798901.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    15. The Autism Spectrum: Human Rights Perspectives. Pediatrics. 2018 04; 141(Suppl 4):S369-S372. Demer LL. PMID: 29610419.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. . 2018 06 01; 314(6):H1203-H1213. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. PMID: 29451816.
      View in: PubMed   Mentions:
    17. Rigor and Reproducibility in Analysis of Vascular Calcification. Circ Res. 2017 04 14; 120(8):1240-1242. Demer LL, Tintut Y, Nguyen KL, Hsiai T, Lee JT. PMID: 28408452.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification. Heart. 2016 11 01; 102(21):1710-1715. Hsu JJ, Lim J, Tintut Y, Demer LL. PMID: 27406839.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. COMP-lex Mechanics: Matricrine Signaling. Circ Res. 2016 07 08; 119(2):184-6. Tintut Y, Demer LL. PMID: 27390328.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    20. Reply: Evolutionary approach sheds light on the significance of vascular calcification. Trends Cardiovasc Med. 2017 01; 27(1):72. Demer LL, Tintut Y. PMID: 27499040.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Inflammation Drives Retraction, Stiffening, and Nodule Formation via Cytoskeletal Machinery in a Three-Dimensional Culture Model of Aortic Stenosis. Am J Pathol. 2016 09; 186(9):2378-89. Lim J, Ehsanipour A, Hsu JJ, Lu J, Pedego T, Wu A, Walthers CM, Demer LL, Seidlits SK, Tintut Y. PMID: 27392969.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    22. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques. Ann Biomed Eng. 2016 09; 44(9):2695-706. Packard RR, Zhang X, Luo Y, Ma T, Jen N, Ma J, Demer LL, Zhou Q, Sayre JW, Li R, Tai YC, Hsiai TK. PMID: 26857007.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    23. Protective Role of Smad6 in Inflammation-Induced Valvular Cell Calcification. J Cell Biochem. 2015 Oct; 116(10):2354-64. Li X, Lim J, Lu J, Pedego TM, Demer L, Tintut Y. PMID: 25864564.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    24. Exosomes: nanosized cellular messages. Circ Res. 2015 Apr 10; 116(8):1281-3. Tintut Y, Demer LL. PMID: 25858057.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Conflicting forces of warfarin and matrix gla protein in the artery wall. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):9-10. Demer LL, Boström KI. PMID: 25520520.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. The leading edge of vascular calcification. Trends Cardiovasc Med. 2015 May; 25(4):275-7. Demer LL, Tintut Y. PMID: 25572012.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014 Nov; 34(11):2387-93. Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. PMID: 25189570.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    28. Inflammatory, metabolic, and genetic mechanisms of vascular calcification. Arterioscler Thromb Vasc Biol. 2014 Apr; 34(4):715-23. Demer LL, Tintut Y. PMID: 24665125.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimals
    29. FGF23 protein expression in coronary arteries is associated with impaired kidney function. Nephrol Dial Transplant. 2014 Aug; 29(8):1525-32. van Venrooij NA, Pereira RC, Tintut Y, Fishbein MC, Tumber N, Demer LL, Salusky IB, Wesseling-Perry K. PMID: 24459137.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    30. Roles of parathyroid hormone (PTH) receptor and reactive oxygen species in hyperlipidemia-induced PTH resistance in preosteoblasts. J Cell Biochem. 2014 Jan; 115(1):179-88. Li X, Garcia J, Lu J, Iriana S, Kalajzic I, Rowe D, Demer LL, Tintut Y. PMID: 24038594.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Effects of bioactive lipids and lipoproteins on bone. Trends Endocrinol Metab. 2014 Feb; 25(2):53-9. Tintut Y, Demer LL. PMID: 24183940.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    32. Introduction to the Compendium on calcific aortic valve disease. Circ Res. 2013 Jul 05; 113(2):176-8. Heistad DD, Shanahan C, Demer LL. PMID: 23833291.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    33. Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):19-24. Lu J, Cheng H, Atti E, Shih DM, Demer LL, Tintut Y. PMID: 23291186.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Regulatory circuits controlling vascular cell calcification. Cell Mol Life Sci. 2013 Sep; 70(17):3187-97. Sallam T, Cheng H, Demer LL, Tintut Y. PMID: 23269436.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Preferred mitotic orientation in pattern formation by vascular mesenchymal cells. . 2012 Dec 15; 303(12):H1411-7. Wong MN, Nguyen TP, Chen TH, Hsu JJ, Zeng X, Saw A, Demer EM, Zhao X, Tintut Y, Demer LL. PMID: 23064835.
      View in: PubMed   Mentions:
    36. Directing tissue morphogenesis via self-assembly of vascular mesenchymal cells. Biomaterials. 2012 Dec; 33(35):9019-26. Chen TH, Zhu X, Pan L, Zeng X, Garfinkel A, Tintut Y, Demer LL, Zhao X, Ho CM. PMID: 23010575.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    37. Focal high cell density generates a gradient of patterns in self-organizing vascular mesenchymal cells. J Vasc Res. 2012; 49(5):441-6. Cheng H, Reddy A, Sage A, Lu J, Garfinkel A, Tintut Y, Demer LL. PMID: 22797747.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Patterns of periodic holes created by increased cell motility. Interface Focus. 2012 Aug 06; 2(4):457-64. Chen TH, Guo C, Zhao X, Yao Y, Boström KI, Wong MN, Tintut Y, Demer LL, Ho CM, Garfinkel A. PMID: 22649581.
      View in: PubMed   Mentions:
    39. Adverse effects of hyperlipidemia on bone regeneration and strength. J Bone Miner Res. 2012 Feb; 27(2):309-18. Pirih F, Lu J, Ye F, Bezouglaia O, Atti E, Ascenzi MG, Tetradis S, Demer L, Aghaloo T, Tintut Y. PMID: 21987408.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    40. Left-right symmetry breaking in tissue morphogenesis via cytoskeletal mechanics. Circ Res. 2012 Feb 17; 110(4):551-9. Chen TH, Hsu JJ, Zhao X, Guo C, Wong MN, Huang Y, Li Z, Garfinkel A, Ho CM, Tintut Y, Demer LL. PMID: 22223355.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    41. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases. . 2012 Feb 15; 302(4):C658-65. Li R, Mittelstein D, Lee J, Fang K, Majumdar R, Tintut Y, Demer LL, Hsiai TK. PMID: 22031601.
      View in: PubMed   Mentions:
    42. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group. Executive summary: Calcific aortic valve disease-2011 update. Circulation. 2011 Oct 18; 124(16):1783-91. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. PMID: 22007101.
      View in: PubMed   Mentions: 230     Fields:    Translation:Humans
    43. Role of cellular cholesterol metabolism in vascular cell calcification. J Biol Chem. 2011 Sep 23; 286(38):33701-6. Geng Y, Hsu JJ, Lu J, Ting TC, Miyazaki M, Demer LL, Tintut Y. PMID: 21835914.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    44. The roles of lipid oxidation products and receptor activator of nuclear factor-?B signaling in atherosclerotic calcification. Circ Res. 2011 Jun 10; 108(12):1482-93. Demer L, Tintut Y. PMID: 21659652.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    45. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res. 2011 Jun; 26(6):1197-206. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y. PMID: 21611962.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    46. Thematic series on the pathobiology of vascular calcification: an introduction. Circ Res. 2011 May 27; 108(11):1378-80. Towler DA, Demer LL. PMID: 21617134.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    47. Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. J Biol Chem. 2011 Jul 08; 286(27):23938-49. Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M. PMID: 21596756.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    48. The hemosteoblast: friend or foe? Circ Res. 2011 Apr 29; 108(9):1038-9. Tintut Y, Demer L. PMID: 21527740.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    49. Runx2-upregulated receptor activator of nuclear factor ?B ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler Thromb Vasc Biol. 2011 Jun; 31(6):1387-96. Byon CH, Sun Y, Chen J, Yuan K, Mao X, Heath JM, Anderson PG, Tintut Y, Demer LL, Wang D, Chen Y. PMID: 21454810.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    50. Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro. Kidney Int. 2011 Feb; 79(4):414-22. Sage AP, Lu J, Tintut Y, Demer LL. PMID: 20944546.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    51. PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. J Biol Chem. 2010 Sep 24; 285(39):29925-31. Tseng W, Graham LS, Geng Y, Reddy A, Lu J, Effros RB, Demer L, Tintut Y. PMID: 20663885.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    52. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol. 2010 Sep; 7(9):528-36. Sage AP, Tintut Y, Demer LL. PMID: 20664518.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    53. The bone-vascular axis in chronic kidney disease. Curr Opin Nephrol Hypertens. 2010 Jul; 19(4):349-53. Demer L, Tintut Y. PMID: 20508522.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    54. Regulation of interleukin-6 expression in osteoblasts by oxidized phospholipids. J Lipid Res. 2010 May; 51(5):1010-6. Tseng W, Lu J, Bishop GA, Watson AD, Sage AP, Demer L, Tintut Y. PMID: 19965598.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. Oxidized lipids enhance RANKL production by T lymphocytes: implications for lipid-induced bone loss. Clin Immunol. 2009 Nov; 133(2):265-75. Graham LS, Parhami F, Tintut Y, Kitchen CM, Demer LL, Effros RB. PMID: 19699688.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    56. Mechanisms linking osteoporosis with cardiovascular calcification. Curr Osteoporos Rep. 2009 Jul; 7(2):42-6. Demer LL, Tintut Y. PMID: 19631027.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    57. Mechanical stress analysis of a rigid inclusion in distensible material: a model of atherosclerotic calcification and plaque vulnerability. . 2009 Aug; 297(2):H802-10. Hoshino T, Chow LA, Hsu JJ, Perlowski AA, Abedin M, Tobis J, Tintut Y, Mal AK, Klug WS, Demer LL. PMID: 19542489.
      View in: PubMed   Mentions:
    58. Systems biology of vascular calcification. Trends Cardiovasc Med. 2009 May; 19(4):118-23. Sage A, Tintut Y, Garfinkel A, Demer L. PMID: 19818947.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    59. T0901317, an LXR agonist, augments PKA-induced vascular cell calcification. FEBS Lett. 2009 Apr 17; 583(8):1344-8. Hsu JJ, Lu J, Huang MS, Geng Y, Sage AP, Bradley MN, Tontonoz P, Demer LL, Tintut Y. PMID: 19327357.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    60. Nanoscale architecture in atherosclerotic calcification. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):1882-4. Demer LL, Sage AP, Tintut Y. PMID: 18946051.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    61. Hyperlipidemia impairs osteoanabolic effects of PTH. J Bone Miner Res. 2008 Oct; 23(10):1672-9. Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y. PMID: 18505371.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    62. Phosphate and pyrophosphate mediate PKA-induced vascular cell calcification. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):553-8. Huang MS, Sage AP, Lu J, Demer LL, Tintut Y. PMID: 18655772.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    63. Vitamin D and osteogenic differentiation in the artery wall. Clin J Am Soc Nephrol. 2008 Sep; 3(5):1542-7. Hsu JJ, Tintut Y, Demer LL. PMID: 18562594.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    64. Vascular calcification: pathobiology of a multifaceted disease. Circulation. 2008 Jun 03; 117(22):2938-48. Demer LL, Tintut Y. PMID: 18519861.
      View in: PubMed   Mentions: 288     Fields:    Translation:Humans
    65. Murine models of atherosclerotic calcification. Curr Drug Targets. 2008 Mar; 9(3):224-8. Hsu JJ, Tintut Y, Demer LL. PMID: 18336241.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    66. Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice. Circulation. 2008 Jan 22; 117(3):411-20. Morony S, Tintut Y, Zhang Z, Cattley RC, Van G, Dwyer D, Stolina M, Kostenuik PJ, Demer LL. PMID: 18172035.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    67. A matter of degree: a commentary on "Influence of oxidized low-density lipoproteins (LDL) on the viability of osteoblastic cells". Free Radic Biol Med. 2008 Feb 15; 44(4):504-5. Demer LL, Tintut Y. PMID: 18005672.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    68. Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts. J Biol Chem. 2007 Jul 20; 282(29):21237-43. Huang MS, Morony S, Lu J, Zhang Z, Bezouglaia O, Tseng W, Tetradis S, Demer LL, Tintut Y. PMID: 17522049.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    69. Mineralocorticoid receptor activation promotes vascular cell calcification. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):799-805. Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME. PMID: 17234727.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    70. Role of osteoprotegerin and its ligands and competing receptors in atherosclerotic calcification. J Investig Med. 2006 Nov; 54(7):395-401. Tintut Y, Demer L. PMID: 17169261.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    71. Mechanical response of a calcified plaque model to fluid shear force. Ann Biomed Eng. 2006 Oct; 34(10):1535-41. Lin TC, Tintut Y, Lyman A, Mack W, Demer LL, Hsiai TK. PMID: 17006755.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    72. Pitting phosphate transport inhibitors against vascular calcification. Circ Res. 2006 Apr 14; 98(7):857-9. Demer LL, Tintut Y. PMID: 16614308.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    73. Regulation of RANKL-induced osteoclastic differentiation by vascular cells. J Mol Cell Cardiol. 2005 Aug; 39(2):389-93. Tintut Y, Abedin M, Cho J, Choe A, Lim J, Demer LL. PMID: 15893766.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    74. Return to ectopia: stem cells in the artery wall. Arterioscler Thromb Vasc Biol. 2005 Jul; 25(7):1307-8. Demer LL, Tintut Y. PMID: 15980267.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    75. Insulin-like growth factor-I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase pathways. Circ Res. 2005 Mar 04; 96(4):398-400. Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer LL, Tintut Y. PMID: 15692088.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    76. Mesenchymal stem cells and the artery wall. Circ Res. 2004 Oct 01; 95(7):671-6. Abedin M, Tintut Y, Demer LL. PMID: 15459088.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    77. Pattern formation by vascular mesenchymal cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9247-50. Garfinkel A, Tintut Y, Petrasek D, Boström K, Demer LL. PMID: 15197273.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    78. Vascular calcification: mechanisms and clinical ramifications. Arterioscler Thromb Vasc Biol. 2004 Jul; 24(7):1161-70. Abedin M, Tintut Y, Demer LL. PMID: 15155384.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimals
    79. Micro sensors: linking real-time oscillatory shear stress with vascular inflammatory responses. Ann Biomed Eng. 2004 Feb; 32(2):189-201. Hsiai TK, Cho SK, Wong PK, Ing MH, Salazar A, Hama S, Navab M, Demer LL, Ho CM. PMID: 15008367.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    80. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):e6-10. Tintut Y, Morony S, Demer LL. PMID: 14670933.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    81. Multilineage potential of cells from the artery wall. Circulation. 2003 Nov 18; 108(20):2505-10. Tintut Y, Alfonso Z, Saini T, Radcliff K, Watson K, Boström K, Demer LL. PMID: 14581408.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    82. Mineral exploration: search for the mechanism of vascular calcification and beyond: the 2003 Jeffrey M. Hoeg Award lecture. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1739-43. Demer LL, Tintut Y. PMID: 12958041.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    83. Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003 Sep; 17(12):1648-57. Hsiai TK, Cho SK, Wong PK, Ing M, Salazar A, Sevanian A, Navab M, Demer LL, Ho CM. PMID: 12958171.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    84. Vascular calcification and its relation to bone calcification: possible underlying mechanisms. J Nucl Cardiol. 2003 Mar-Apr; 10(2):177-83. Mody N, Tintut Y, Radcliff K, Demer LL. PMID: 12673183.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    85. Role of the cholesterol biosynthetic pathway in osteoblastic differentiation of marrow stromal cells. J Bone Miner Res. 2002 Nov; 17(11):1997-2003. Parhami F, Mody N, Gharavi N, Ballard AJ, Tintut Y, Demer LL. PMID: 12412807.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    86. High-density lipoprotein regulates calcification of vascular cells. Circ Res. 2002 Oct 04; 91(7):570-6. Parhami F, Basseri B, Hwang J, Tintut Y, Demer LL. PMID: 12364384.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    87. Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids. Int J Epidemiol. 2002 Aug; 31(4):737-41. Demer LL. PMID: 12177011.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    88. Novel mechanisms in accelerated vascular calcification in renal disease patients. Curr Opin Nephrol Hypertens. 2002 Jul; 11(4):437-43. Demer LL, Tintut Y, Parhami F. PMID: 12105395.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    89. Endothelial cell dynamics under pulsating flows: significance of high versus low shear stress slew rates (d(tau)/dt). Ann Biomed Eng. 2002 May; 30(5):646-56. Hsiai TK, Cho SK, Honda HM, Hama S, Navab M, Demer LL, Ho CM. PMID: 12108839.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    90. Adipose rex: fat and fats that rule differentiation. Circ Res. 2002 Feb 22; 90(3):241-3. Demer LL. PMID: 11861408.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    91. Monocyte/macrophage regulation of vascular calcification in vitro. Circulation. 2002 Feb 05; 105(5):650-5. Tintut Y, Patel J, Territo M, Saini T, Parhami F, Demer LL. PMID: 11827934.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    92. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway. J Biol Chem. 2002 Apr 19; 277(16):14221-6. Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL. PMID: 11827970.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
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