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Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis. Elife. 2023 Nov 28; 12.
Kondo T, Gleason A, Okawa H, Hokugo A, Nishimura I. PMID: 38015204; PMCID: PMC10684155.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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A scoping review of graphene-based biomaterials for in vivo bone tissue engineering. J Biomater Appl. 2023 09; 38(3):313-350.
Achôa GL, Mattos PA, Clements A, Roca Y, Brooks Z, Ferreira JRM, Canal R, Fernandes TL, Riera R, Amano MT, Hokugo A, Jarrahy R, Lenz E Silva GF, Bueno DF. PMID: 37493398.
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PubMed Mentions:
1 Fields:
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Mouse gingival single-cell transcriptomic atlas: An activated fibroblast subpopulation guides oral barrier immunity in periodontitis. bioRxiv. 2023 Jul 24.
Kondo T, Gleason A, Okawa H, Hokugo A, Nishimura I. PMID: 37546811; PMCID: PMC10401928.
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In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing. Front Med (Lausanne). 2022; 9:1014763.
Clements A, Shibuya Y, Hokugo A, Brooks Z, Roca Y, Kondo T, Nishimura I, Jarrahy R. PMID: 36816724; PMCID: PMC9928850.
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PubMed Mentions:
3
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Augmentation of IFN-γ by bone marrow derived immune cells in the presence of severe suppression of IFN-γ in gingivae induced by zoledronic acid and denosumab in Hu-BLT mice model of ONJ. Front Endocrinol (Lausanne). 2023; 14:1111627.
Kaur K, Sun Y, Kanayama K, Morinaga K, Hokugo A, Nishimura I, Jewett A. PMID: 36742414; PMCID: PMC9895394.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice. Commun Biol. 2022 09 14; 5(1):962.
Kondo T, Okawa H, Hokugo A, Shokeen B, Sundberg O, Zheng Y, McKenna CE, Lux R, Nishimura I. PMID: 36104423; PMCID: PMC9474870.
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PubMed Mentions:
5 Translation:
AnimalsCells
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Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice. Commun Med (Lond). 2022; 2:112.
Okawa H, Kondo T, Hokugo A, Cherian P, Sundberg O, Campagna JJ, Kashemirov BA, John V, Sun S, Ebetino FH, McKenna CE, Nishimura I. PMID: 36082175; PMCID: PMC9445170.
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PubMed Mentions:
1
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Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate. Elife. 2022 08 26; 11.
Okawa H, Kondo T, Hokugo A, Cherian P, Campagna JJ, Lentini NA, Sung EC, Chiang S, Lin YL, Ebetino FH, John V, Sun S, McKenna CE, Nishimura I. PMID: 36017995; PMCID: PMC9489207.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing. Elife. 2022 01 18; 11.
Shibuya Y, Hokugo A, Okawa H, Kondo T, Khalil D, Wang L, Roca Y, Clements A, Sasaki H, Berry E, Nishimura I, Jarrahy R. PMID: 35040776; PMCID: PMC8789286.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model. Bioconjug Chem. 2021 May 19; 32(5):916-927.
Richard ET, Morinaga K, Zheng Y, Sundberg O, Hokugo A, Hui K, Zhou Y, Sasaki H, Kashemirov BA, Nishimura I, McKenna CE. PMID: 33956423; PMCID: PMC8137654.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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A Chemotactic Functional Scaffold with VEGF-Releasing Peptide Amphiphiles Facilitates Bone Regeneration by BMP-2 in a Large-Scale Rodent Cranial Defect Model. Plast Reconstr Surg. 2021 02 01; 147(2):386-397.
Bakshi R, Hokugo A, Khalil D, Wang L, Shibuya Y, Zhou S, Zhang Z, Rezzadeh K, McClendon M, Stupp SI, Jarrahy R. PMID: 33235044.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations. Stem Cell Res Ther. 2020 11 25; 11(1):501.
Bueno DF, Kabayashi GS, Pinheiro CCG, Tanikawa DYS, Raposo-Amaral CE, Rocha DL, Ferreira JRM, Shibuya Y, Hokugo A, Jarrahy R, ZuK PA, Passos-Bueno MR. PMID: 33239080; PMCID: PMC7687766.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Application of Hydroxycholesterols for Alveolar Cleft Osteoplasty in a Rodent Model. Plast Reconstr Surg. 2019 05; 143(5):1385-1395.
Bakshi R, Hokugo A, Zhou S, Zhang Z, Wang L, Rezzadeh K, Segovia LA, Jarrahy R. PMID: 30789479.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Bioactive peptide amphiphile nanofiber gels enhance burn wound healing. Burns. 2019 08; 45(5):1112-1121.
Zhou S, Hokugo A, McClendon M, Zhang Z, Bakshi R, Wang L, Segovia LA, Rezzadeh K, Stupp SI, Jarrahy R. PMID: 31043333.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction. Anat Rec (Hoboken). 2020 06; 303(6):1630-1641.
Sasaki H, Hokugo A, Wang L, Morinaga K, Ngo JT, Okawa H, Nishimura I. PMID: 30851151; PMCID: PMC6733676.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice. Bone. 2019 06; 123:115-128.
Hokugo A, Kanayama K, Sun S, Morinaga K, Sun Y, Wu Q, Sasaki H, Okawa H, Evans C, Ebetino FH, Lundy MW, Sadrerafi K, McKenna CE, Nishimura I. PMID: 30926440; PMCID: PMC7282713.
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PubMed Mentions:
14 Fields:
Translation:
Animals
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Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism. Biomaterials. 2019 02; 192:62-74.
Morinaga K, Sasaki H, Park S, Hokugo A, Okawa H, Tahara Y, Colwell CS, Nishimura I. PMID: 30428407; PMCID: PMC6389329.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1203-H1213.
Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. PMID: 29451816; PMCID: PMC6032086.
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PubMed Mentions:
17 Fields:
Translation:
Animals
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Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. PLoS One. 2017; 12(8):e0183359.
Hassan N, McCarville K, Morinaga K, Mengatto CM, Langfelder P, Hokugo A, Tahara Y, Colwell CS, Nishimura I. PMID: 28817668; PMCID: PMC5560683.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. J Drug Deliv. 2017; 2017:4759839.
Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V. PMID: 28480080; PMCID: PMC5396447.
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PubMed Mentions:
6
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Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-related Osteonecrosis of the Jaw. J Biol Chem. 2016 09 23; 291(39):20602-16.
Sun Y, Kaur K, Kanayama K, Morinaga K, Park S, Hokugo A, Kozlowska A, McBride WH, Li J, Jewett A, Nishimura I. PMID: 27514746; PMCID: PMC5034053.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Natural Killer Cells Differentiate Human Adipose-Derived Stem Cells and Modulate Their Adipogenic Potential. Plast Reconstr Surg. 2015 Sep; 136(3):503-510.
Rezzadeh KS, Hokugo A, Jewett A, Kozlowska A, Segovia LA, Zuk P, Jarrahy R. PMID: 26313823.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Oxy133, a novel osteogenic agent, promotes bone regeneration in an intramembranous bone-healing model. J Tissue Eng Regen Med. 2017 05; 11(5):1490-1499.
Li A, Hokugo A, Segovia LA, Yalom A, Rezzadeh K, Zhou S, Zhang Z, Parhami F, Stappenbeck F, Jarrahy R. PMID: 26073881.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Development of chemotactic smart scaffold for use in tissue regeneration. Plast Reconstr Surg. 2015 May; 135(5):877e-884e.
Hokugo A, Li A, Segovia LA, Yalom A, Rezzadeh K, Zhou S, Zhang Z, Zuk PA, Jarrahy R. PMID: 25919270.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone regeneration of X-ray-irradiated rabbit ulnar defects. Biomaterials. 2015 Jul; 56:18-25.
Yamamoto M, Hokugo A, Takahashi Y, Nakano T, Hiraoka M, Tabata Y. PMID: 25934275.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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In vitro osteoinductive effects of hydroxycholesterol on human adipose-derived stem cells are mediated through the hedgehog signaling pathway. Plast Reconstr Surg. 2014 Nov; 134(5):960-968.
Yalom A, Hokugo A, Sorice S, Li A, Segovia Aguilar LA, Zuk P, Jarrahy R. PMID: 25347631.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding. J Bone Miner Res. 2014 Aug; 29(8):1872-85.
Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F. PMID: 24591126; PMCID: PMC4457783.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers. Biomaterials. 2014 Oct; 35(31):8780-8790.
Li A, Hokugo A, Yalom A, Berns EJ, Stephanopoulos N, McClendon MT, Segovia LA, Spigelman I, Stupp SI, Jarrahy R. PMID: 25064803; PMCID: PMC4289709.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel. Biomaterials. 2014 Jul; 35(21):5565-71.
Hokugo A, Saito T, Li A, Sato K, Tabata Y, Jarrahy R. PMID: 24731715.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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A novel oxysterol promotes bone regeneration in rabbit cranial bone defects. J Tissue Eng Regen Med. 2016 07; 10(7):591-9.
Hokugo A, Sorice S, Parhami F, Yalom A, Li A, Zuk P, Jarrahy R. PMID: 23997014.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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In vitro study of a novel oxysterol for osteogenic differentiation on rabbit bone marrow stromal cells. Plast Reconstr Surg. 2013 Jul; 132(1):70e-80e.
Hokugo A, Sorice S, Yalom A, Lee JC, Li A, Zuk P, Jarrahy R. PMID: 23806956.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats. Bone. 2013 Mar; 53(1):59-68.
Hokugo A, Sun S, Park S, McKenna CE, Nishimura I. PMID: 23219943; PMCID: PMC3552081.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Brachytherapy-mediated bone damage in a rat model investigating maxillary osteoradionecrosis. Arch Otolaryngol Head Neck Surg. 2012 Feb; 138(2):167-71.
Armin BB, Hokugo A, Nishimura I, Tamplen M, Beumer J, Steinberg ML, Abemayor E, Nabili V. PMID: 22351863.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsPHPublic Health
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[Vitamin D and bisphosphonate-related osteonecrosis of the jaw (BRONJ) ]. Clin Calcium. 2012 Jan; 22(1):83-90.
Hokugo A. PMID: 22201103.
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Translation:
HumansAnimalsCells
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A novel hydroxyapatite ceramic bone substitute transformed by ostrich cancellous bone: characterization and evaluations of bone regeneration activity. J Biomed Mater Res B Appl Biomater. 2011 Aug; 98(2):217-22.
Sawada Y, Hokugo A, Yang Y, Kamitani M, Matsuda S, Mao T, Lei D, Chen F, Iseki T, Morita S. PMID: 21681951.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Molecular effects of fractional carbon dioxide laser resurfacing on photodamaged human skin. Arch Facial Plast Surg. 2010 Sep-Oct; 12(5):321-5.
Reilly MJ, Cohen M, Hokugo A, Keller GS. PMID: 20855774.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Animal model of radiogenic bone damage to study mandibular osteoradionecrosis. Am J Otolaryngol. 2011 Jul-Aug; 32(4):291-300.
Cohen M, Nishimura I, Tamplen M, Hokugo A, Beumer J, Steinberg ML, Suh JD, Abemayor E, Nabili V. PMID: 20719407.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsPHPublic Health
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Wound closure and wound management: A new therapeutic molecular target. Cell Adh Migr. 2010 Jul-Sep; 4(3):396-9.
Lin A, Hokugo A, Nishimura I. PMID: 20448469; PMCID: PMC2958616.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res. 2010 Jun; 25(6):1337-49.
Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura I. PMID: 20200938; PMCID: PMC3153137.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Am J Pathol. 2010 Jan; 176(1):108-21.
Lin A, Hokugo A, Choi J, Nishimura I. PMID: 19959814; PMCID: PMC2797874.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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A trial of alveolar cleft bone regeneration by controlled release of bone morphogenetic protein: an experimental study in rabbits. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Dec; 108(6):812-20.
Sawada Y, Hokugo A, Nishiura A, Hokugo R, Matsumoto N, Morita S, Tabata Y. PMID: 19782619.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone. J Bone Miner Res. 2008 Jun; 23(6):837-49.
Wang CJ, Iida K, Egusa H, Hokugo A, Jewett A, Nishimura I. PMID: 18251701; PMCID: PMC2677084.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping. Tissue Eng Part C Methods. 2008 Mar; 14(1):47-57.
Kimura Y, Hokugo A, Takamoto T, Tabata Y, Kurosawa H. PMID: 18454645.
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PubMed Mentions:
27 Fields:
Translation:
Animals
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The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng. 2007 May; 13(5):1103-12.
Ishida K, Kuroda R, Miwa M, Tabata Y, Hokugo A, Kawamoto T, Sasaki K, Doita M, Kurosaka M. PMID: 17348798.
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PubMed Mentions:
106 Fields:
Translation:
AnimalsCells
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Controlled release of platelet growth factors enhances bone regeneration at rabbit calvaria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul; 104(1):44-8.
Hokugo A, Sawada Y, Hokugo R, Iwamura H, Kobuchi M, Kambara T, Morita S, Tabata Y. PMID: 17376715.
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PubMed Mentions:
15 Fields:
Translation:
Animals
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Preparation of prefabricated vascularized bone graft with neoangiogenesis by combination of autologous tissue and biodegradable materials. Int J Oral Maxillofac Surg. 2006 Nov; 35(11):1034-40.
Hokugo A, Sawada Y, Sugimoto K, Fukuda A, Mushimoto K, Morita S, Tabata Y. PMID: 16965895.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: evolving concept of biologic coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2006 Oct; 132(4):891-99.
Takaba K, Jiang C, Nemoto S, Saji Y, Ikeda T, Urayama S, Azuma T, Hokugo A, Tsutsumi S, Tabata Y, Komeda M. PMID: 17000302.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber. Biomaterials. 2006 Jan; 27(1):61-7.
Hokugo A, Takamoto T, Tabata Y. PMID: 16000222.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCellsPHPublic Health
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Augmented bone regeneration activity of platelet-rich plasma by biodegradable gelatin hydrogel. Tissue Eng. 2005 Jul-Aug; 11(7-8):1224-33.
Hokugo A, Ozeki M, Kawakami O, Sugimoto K, Mushimoto K, Morita S, Tabata Y. PMID: 16144458.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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Prefabrication of vascularized bone graft using guided bone regeneration. Tissue Eng. 2004 Jul-Aug; 10(7-8):978-86.
Hokugo A, Kubo Y, Takahashi Y, Fukuda A, Horiuchi K, Mushimoto K, Morita S, Tabata Y. PMID: 15363155.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells