Akishige Hokugo

Title(s)Associate Adjunct Professor, Surgery
ORCID ORCID Icon0000-0002-7097-3364 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Japanese Society of Oral and Maxillofacial Surgeons2003The Scientific Award
    UCLA School of Dentistry's Research Day Poster Competition2008Second Prize
    The American Society for Bone and Mineral Research2009Plenary Poster
    Japanese Society of Oral and Maxillofacial Surgeons2011The Best Presentation Award
    American Association of Oral and Maxillofacial Surgeons 2014Oral Abstract Scientific Presentation Award
    American Society of Maxillofacial Surgeons 2014Best Scientific Paper Award
    The American Society of Craniofacial Surgery2016Kawamoto Best Paper Award (Co-author)
    The American Society for Bone and Mineral Research 2016Plenary Poster
    The American Society for Bone and Mineral Research 2017Plenary Poster
    Plastic Surgery Research Council 2020Best Papers in Wound Healing
    UCLA Undergraduate Research Week 2022Faculty Mentor Award

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis. Elife. 2023 Nov 28; 12. Kondo T, Gleason A, Okawa H, Hokugo A, Nishimura I. PMID: 38015204; PMCID: PMC10684155.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    2. A scoping review of graphene-based biomaterials for in vivo bone tissue engineering. J Biomater Appl. 2023 09; 38(3):313-350. Achôa GL, Mattos PA, Clements A, Roca Y, Brooks Z, Ferreira JRM, Canal R, Fernandes TL, Riera R, Amano MT, Hokugo A, Jarrahy R, Lenz E Silva GF, Bueno DF. PMID: 37493398.
      View in: PubMed   Mentions: 1     Fields:    
    3. Mouse gingival single-cell transcriptomic atlas: An activated fibroblast subpopulation guides oral barrier immunity in periodontitis. bioRxiv. 2023 Jul 24. Kondo T, Gleason A, Okawa H, Hokugo A, Nishimura I. PMID: 37546811; PMCID: PMC10401928.
      View in: PubMed   Mentions:
    4. In vitro assessment of Neuronal PAS domain 2 mitigating compounds for scarless wound healing. Front Med (Lausanne). 2022; 9:1014763. Clements A, Shibuya Y, Hokugo A, Brooks Z, Roca Y, Kondo T, Nishimura I, Jarrahy R. PMID: 36816724; PMCID: PMC9928850.
      View in: PubMed   Mentions: 2  
    5. Augmentation of IFN-γ by bone marrow derived immune cells in the presence of severe suppression of IFN-γ in gingivae induced by zoledronic acid and denosumab in Hu-BLT mice model of ONJ. Front Endocrinol (Lausanne). 2023; 14:1111627. Kaur K, Sun Y, Kanayama K, Morinaga K, Hokugo A, Nishimura I, Jewett A. PMID: 36742414; PMCID: PMC9895394.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    6. Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice. Commun Biol. 2022 09 14; 5(1):962. Kondo T, Okawa H, Hokugo A, Shokeen B, Sundberg O, Zheng Y, McKenna CE, Lux R, Nishimura I. PMID: 36104423; PMCID: PMC9474870.
      View in: PubMed   Mentions: 4  Translation:AnimalsCells
    7. Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice. Commun Med (Lond). 2022; 2:112. Okawa H, Kondo T, Hokugo A, Cherian P, Sundberg O, Campagna JJ, Kashemirov BA, John V, Sun S, Ebetino FH, McKenna CE, Nishimura I. PMID: 36082175; PMCID: PMC9445170.
      View in: PubMed   Mentions: 1  
    8. Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate. Elife. 2022 08 26; 11. Okawa H, Kondo T, Hokugo A, Cherian P, Campagna JJ, Lentini NA, Sung EC, Chiang S, Lin YL, Ebetino FH, John V, Sun S, McKenna CE, Nishimura I. PMID: 36017995; PMCID: PMC9489207.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    9. Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing. Elife. 2022 01 18; 11. Shibuya Y, Hokugo A, Okawa H, Kondo T, Khalil D, Wang L, Roca Y, Clements A, Sasaki H, Berry E, Nishimura I, Jarrahy R. PMID: 35040776; PMCID: PMC8789286.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model. Bioconjug Chem. 2021 05 19; 32(5):916-927. Richard ET, Morinaga K, Zheng Y, Sundberg O, Hokugo A, Hui K, Zhou Y, Sasaki H, Kashemirov BA, Nishimura I, McKenna CE. PMID: 33956423; PMCID: PMC8137654.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. A Chemotactic Functional Scaffold with VEGF-Releasing Peptide Amphiphiles Facilitates Bone Regeneration by BMP-2 in a Large-Scale Rodent Cranial Defect Model. Plast Reconstr Surg. 2021 02 01; 147(2):386-397. Bakshi R, Hokugo A, Khalil D, Wang L, Shibuya Y, Zhou S, Zhang Z, Rezzadeh K, McClendon M, Stupp SI, Jarrahy R. PMID: 33235044.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations. Stem Cell Res Ther. 2020 11 25; 11(1):501. Bueno DF, Kabayashi GS, Pinheiro CCG, Tanikawa DYS, Raposo-Amaral CE, Rocha DL, Ferreira JRM, Shibuya Y, Hokugo A, Jarrahy R, ZuK PA, Passos-Bueno MR. PMID: 33239080; PMCID: PMC7687766.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    13. Application of Hydroxycholesterols for Alveolar Cleft Osteoplasty in a Rodent Model. Plast Reconstr Surg. 2019 05; 143(5):1385-1395. Bakshi R, Hokugo A, Zhou S, Zhang Z, Wang L, Rezzadeh K, Segovia LA, Jarrahy R. PMID: 30789479.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Bioactive peptide amphiphile nanofiber gels enhance burn wound healing. Burns. 2019 08; 45(5):1112-1121. Zhou S, Hokugo A, McClendon M, Zhang Z, Bakshi R, Wang L, Segovia LA, Rezzadeh K, Stupp SI, Jarrahy R. PMID: 31043333.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    15. Neuronal PAS Domain 2 (Npas2)-Deficient Fibroblasts Accelerate Skin Wound Healing and Dermal Collagen Reconstruction. Anat Rec (Hoboken). 2020 06; 303(6):1630-1641. Sasaki H, Hokugo A, Wang L, Morinaga K, Ngo JT, Okawa H, Nishimura I. PMID: 30851151; PMCID: PMC6733676.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice. Bone. 2019 06; 123:115-128. Hokugo A, Kanayama K, Sun S, Morinaga K, Sun Y, Wu Q, Sasaki H, Okawa H, Evans C, Ebetino FH, Lundy MW, Sadrerafi K, McKenna CE, Nishimura I. PMID: 30926440; PMCID: PMC7282713.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    17. Neuronal PAS domain 2 (Npas2) facilitated osseointegration of titanium implant with rough surface through a neuroskeletal mechanism. Biomaterials. 2019 02; 192:62-74. Morinaga K, Sasaki H, Park S, Hokugo A, Okawa H, Tahara Y, Colwell CS, Nishimura I. PMID: 30428407; PMCID: PMC6389329.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1203-H1213. Hsu JJ, Lu J, Umar S, Lee JT, Kulkarni RP, Ding Y, Chang CC, Hsiai TK, Hokugo A, Gkouveris I, Tetradis S, Nishimura I, Demer LL, Tintut Y. PMID: 29451816; PMCID: PMC6032086.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    19. Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells. PLoS One. 2017; 12(8):e0183359. Hassan N, McCarville K, Morinaga K, Mengatto CM, Langfelder P, Hokugo A, Tahara Y, Colwell CS, Nishimura I. PMID: 28817668; PMCID: PMC5560683.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. J Drug Deliv. 2017; 2017:4759839. Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V. PMID: 28480080; PMCID: PMC5396447.
      View in: PubMed   Mentions: 6  
    21. Plasticity of Myeloid Cells during Oral Barrier Wound Healing and the Development of Bisphosphonate-related Osteonecrosis of the Jaw. J Biol Chem. 2016 09 23; 291(39):20602-16. Sun Y, Kaur K, Kanayama K, Morinaga K, Park S, Hokugo A, Kozlowska A, McBride WH, Li J, Jewett A, Nishimura I. PMID: 27514746; PMCID: PMC5034053.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. Natural Killer Cells Differentiate Human Adipose-Derived Stem Cells and Modulate Their Adipogenic Potential. Plast Reconstr Surg. 2015 Sep; 136(3):503-510. Rezzadeh KS, Hokugo A, Jewett A, Kozlowska A, Segovia LA, Zuk P, Jarrahy R. PMID: 26313823.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Oxy133, a novel osteogenic agent, promotes bone regeneration in an intramembranous bone-healing model. J Tissue Eng Regen Med. 2017 05; 11(5):1490-1499. Li A, Hokugo A, Segovia LA, Yalom A, Rezzadeh K, Zhou S, Zhang Z, Parhami F, Stappenbeck F, Jarrahy R. PMID: 26073881.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    24. Development of chemotactic smart scaffold for use in tissue regeneration. Plast Reconstr Surg. 2015 May; 135(5):877e-884e. Hokugo A, Li A, Segovia LA, Yalom A, Rezzadeh K, Zhou S, Zhang Z, Zuk PA, Jarrahy R. PMID: 25919270.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    25. Combination of BMP-2-releasing gelatin/β-TCP sponges with autologous bone marrow for bone regeneration of X-ray-irradiated rabbit ulnar defects. Biomaterials. 2015 Jul; 56:18-25. Yamamoto M, Hokugo A, Takahashi Y, Nakano T, Hiraoka M, Tabata Y. PMID: 25934275.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    26. In vitro osteoinductive effects of hydroxycholesterol on human adipose-derived stem cells are mediated through the hedgehog signaling pathway. Plast Reconstr Surg. 2014 Nov; 134(5):960-968. Yalom A, Hokugo A, Sorice S, Li A, Segovia Aguilar LA, Zuk P, Jarrahy R. PMID: 25347631.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding. J Bone Miner Res. 2014 Aug; 29(8):1872-85. Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F. PMID: 24591126; PMCID: PMC4457783.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers. Biomaterials. 2014 Oct; 35(31):8780-8790. Li A, Hokugo A, Yalom A, Berns EJ, Stephanopoulos N, McClendon MT, Segovia LA, Spigelman I, Stupp SI, Jarrahy R. PMID: 25064803; PMCID: PMC4289709.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    29. Stimulation of bone regeneration following the controlled release of water-insoluble oxysterol from biodegradable hydrogel. Biomaterials. 2014 Jul; 35(21):5565-71. Hokugo A, Saito T, Li A, Sato K, Tabata Y, Jarrahy R. PMID: 24731715.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. A novel oxysterol promotes bone regeneration in rabbit cranial bone defects. J Tissue Eng Regen Med. 2016 07; 10(7):591-9. Hokugo A, Sorice S, Parhami F, Yalom A, Li A, Zuk P, Jarrahy R. PMID: 23997014.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    31. In vitro study of a novel oxysterol for osteogenic differentiation on rabbit bone marrow stromal cells. Plast Reconstr Surg. 2013 Jul; 132(1):70e-80e. Hokugo A, Sorice S, Yalom A, Lee JC, Li A, Zuk P, Jarrahy R. PMID: 23806956.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    32. Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains anti-resorptive pharmacokinetics and prevalence of osteonecrosis of the jaw in rats. Bone. 2013 Mar; 53(1):59-68. Hokugo A, Sun S, Park S, McKenna CE, Nishimura I. PMID: 23219943; PMCID: PMC3552081.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    33. Brachytherapy-mediated bone damage in a rat model investigating maxillary osteoradionecrosis. Arch Otolaryngol Head Neck Surg. 2012 Feb; 138(2):167-71. Armin BB, Hokugo A, Nishimura I, Tamplen M, Beumer J, Steinberg ML, Abemayor E, Nabili V. PMID: 22351863.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsPHPublic Health
    34. [Vitamin D and bisphosphonate-related osteonecrosis of the jaw (BRONJ) ]. Clin Calcium. 2012 Jan; 22(1):83-90. Hokugo A. PMID: 22201103.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. A novel hydroxyapatite ceramic bone substitute transformed by ostrich cancellous bone: characterization and evaluations of bone regeneration activity. J Biomed Mater Res B Appl Biomater. 2011 Aug; 98(2):217-22. Sawada Y, Hokugo A, Yang Y, Kamitani M, Matsuda S, Mao T, Lei D, Chen F, Iseki T, Morita S. PMID: 21681951.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    36. Molecular effects of fractional carbon dioxide laser resurfacing on photodamaged human skin. Arch Facial Plast Surg. 2010 Sep-Oct; 12(5):321-5. Reilly MJ, Cohen M, Hokugo A, Keller GS. PMID: 20855774.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    37. Animal model of radiogenic bone damage to study mandibular osteoradionecrosis. Am J Otolaryngol. 2011 Jul-Aug; 32(4):291-300. Cohen M, Nishimura I, Tamplen M, Hokugo A, Beumer J, Steinberg ML, Suh JD, Abemayor E, Nabili V. PMID: 20719407.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsPHPublic Health
    38. Wound closure and wound management: A new therapeutic molecular target. Cell Adh Migr. 2010 Jul-Sep; 4(3):396-9. Lin A, Hokugo A, Nishimura I. PMID: 20448469; PMCID: PMC2958616.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    39. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res. 2010 Jun; 25(6):1337-49. Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura I. PMID: 20200938; PMCID: PMC3153137.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    40. Small cytoskeleton-associated molecule, fibroblast growth factor receptor 1 oncogene partner 2/wound inducible transcript-3.0 (FGFR1OP2/wit3.0), facilitates fibroblast-driven wound closure. Am J Pathol. 2010 Jan; 176(1):108-21. Lin A, Hokugo A, Choi J, Nishimura I. PMID: 19959814; PMCID: PMC2797874.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    41. A trial of alveolar cleft bone regeneration by controlled release of bone morphogenetic protein: an experimental study in rabbits. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Dec; 108(6):812-20. Sawada Y, Hokugo A, Nishiura A, Hokugo R, Matsumoto N, Morita S, Tabata Y. PMID: 19782619.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    42. Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone. J Bone Miner Res. 2008 Jun; 23(6):837-49. Wang CJ, Iida K, Egusa H, Hokugo A, Jewett A, Nishimura I. PMID: 18251701; PMCID: PMC2677084.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    43. Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping. Tissue Eng Part C Methods. 2008 Mar; 14(1):47-57. Kimura Y, Hokugo A, Takamoto T, Tabata Y, Kurosawa H. PMID: 18454645.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    44. The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng. 2007 May; 13(5):1103-12. Ishida K, Kuroda R, Miwa M, Tabata Y, Hokugo A, Kawamoto T, Sasaki K, Doita M, Kurosaka M. PMID: 17348798.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    45. Controlled release of platelet growth factors enhances bone regeneration at rabbit calvaria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul; 104(1):44-8. Hokugo A, Sawada Y, Hokugo R, Iwamura H, Kobuchi M, Kambara T, Morita S, Tabata Y. PMID: 17376715.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    46. Preparation of prefabricated vascularized bone graft with neoangiogenesis by combination of autologous tissue and biodegradable materials. Int J Oral Maxillofac Surg. 2006 Nov; 35(11):1034-40. Hokugo A, Sawada Y, Sugimoto K, Fukuda A, Mushimoto K, Morita S, Tabata Y. PMID: 16965895.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    47. A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: evolving concept of biologic coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2006 Oct; 132(4):891-99. Takaba K, Jiang C, Nemoto S, Saji Y, Ikeda T, Urayama S, Azuma T, Hokugo A, Tsutsumi S, Tabata Y, Komeda M. PMID: 17000302.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    48. Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber. Biomaterials. 2006 Jan; 27(1):61-7. Hokugo A, Takamoto T, Tabata Y. PMID: 16000222.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    49. Augmented bone regeneration activity of platelet-rich plasma by biodegradable gelatin hydrogel. Tissue Eng. 2005 Jul-Aug; 11(7-8):1224-33. Hokugo A, Ozeki M, Kawakami O, Sugimoto K, Mushimoto K, Morita S, Tabata Y. PMID: 16144458.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    50. Prefabrication of vascularized bone graft using guided bone regeneration. Tissue Eng. 2004 Jul-Aug; 10(7-8):978-86. Hokugo A, Kubo Y, Takahashi Y, Fukuda A, Horiuchi K, Mushimoto K, Morita S, Tabata Y. PMID: 15363155.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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