Varghese John

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Screening for Compounds that Lower Intracellular Alpha-Synuclein Levels
    NIH R21AG063007May 15, 2021 - Apr 30, 2023
    Role: Principal Investigator
    Small molecule mimetics of Humanin that normalize neuronal p-Akt as novel therapeutics for AD
    NIH RF1AG068116Apr 1, 2021 - Mar 31, 2024
    Role: Principal Investigator
    Screening for enhancers of secreted clusterin (sCLU) and evaluation in AD models
    NIH R21AG072150Apr 1, 2021 - Mar 31, 2023
    Role: Principal Investigator
    Screening for SORLA enhancers and evaluation in AD models
    NIH R21AG067461Apr 15, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Screening for enhancers of sAPPalpha
    NIH R21AG052195May 1, 2016 - Apr 30, 2019
    Role: Principal Investigator
    ApoE4-targeted therapeutics that normalize SirT1
    NIH R01AG051386Aug 15, 2015 - Mar 31, 2021
    Role: Principal Investigator
    Screening for APPNeo Inhibitors
    NIH R21AG041456Aug 1, 2012 - Jul 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta. Lab Invest. 2021 Aug 30. Miyoshi E, Bilousova T, Melnik M, Fakhrutdinov D, Poon WW, Vinters HV, Miller CA, Corrada M, Kawas C, Bohannan R, Caraway C, Elias C, Maina KN, Campagna JJ, John V, Gylys KH. PMID: 34462532.
      View in: PubMed   Mentions:    Fields:    
    2. Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and a-synuclein pathology in a Parkinson's disease model. Mol Brain. 2021 Jul 08; 14(1):108. Zhu C, Bilousova T, Focht S, Jun M, Elias CJ, Melnik M, Chandra S, Campagna J, Cohn W, Hatami A, Spilman P, Gylys KH, John V. PMID: 34238327.
      View in: PubMed   Mentions:    Fields:    
    3. Pharmacological inhibition of nSMase2 reduces brain exosome release and a-synuclein pathology in a Parkinson's disease model. Mol Brain. 2021 04 19; 14(1):70. Zhu C, Bilousova T, Focht S, Jun M, Elias CJ, Melnik M, Chandra S, Campagna J, Cohn W, Hatami A, Spilman P, Gylys KH, John V. PMID: 33875010.
      View in: PubMed   Mentions: 1     Fields:    
    4. Behavioral Deficits and Brain a-Synuclein and Phosphorylated Serine-129 a-Synuclein in Male and Female Mice Overexpressing Human a-Synuclein. J Alzheimers Dis. 2021; 79(2):875-893. Gabrielyan L, Liang H, Minalyan A, Hatami A, John V, Wang L. PMID: 33361597.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIß Signaling in Limb Girdle Muscular Dystrophy. Cell Rep Med. 2020 Oct 20; 1(7):100122. Liu J, Campagna J, John V, Damoiseaux R, Mokhonova E, Becerra D, Meng H, McNally EM, Pyle AD, Kramerova I, Spencer MJ. PMID: 33205074.
      View in: PubMed   Mentions:
    6. High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy. Skelet Muscle. 2020 09 18; 10(1):26. Shu C, Parfenova L, Mokhonova E, Collado JR, Damoiseaux R, Campagna J, John V, Crosbie RH. PMID: 32948250.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ACS Chem Biol. 2020 06 19; 15(6):1671-1684. Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V. PMID: 32352753.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Shotgun Proteomic Profiling of Bloodborne Nanoscale Extracellular Vesicles. Methods Mol Biol. 2019; 1897:403-416. Heinzelman P, Powers DN, Wohlschlegel JA, John V. PMID: 30539460.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Synthesis of Fused Indolines by Interrupted Fischer Indolization in a Microfluidic Reactor. Tetrahedron Lett. 2019 Jan 17; 60(3):322-326. Duong AT, Simmons BJ, Alam MP, Campagna J, Garg NK, John V. PMID: 30631216.
      View in: PubMed   Mentions:    Fields:    
    10. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 12 04; 8(1):17574. Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, Cole G, LaDu MJ, Jung ME, Bredesen DE, John V. PMID: 30514854.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol Biol. 2018 05 25; 430(11):1566-1576. Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, John V. PMID: 29649434.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem Biophys Res Commun. 2018 05 23; 499(4):751-757. Bilousova T, Elias C, Miyoshi E, Alam MP, Zhu C, Campagna J, Vadivel K, Jagodzinska B, Gylys KH, John V. PMID: 29604274.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 05; 77(5):760-769. Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. PMID: 29436471.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    14. A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. ACS Chem Neurosci. 2018 03 21; 9(3):462-468. Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D, John V. PMID: 29161500.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    15. Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. J Drug Deliv. 2017; 2017:4759839. Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V. PMID: 28480080.
      View in: PubMed   Mentions:
    16. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017; 8:46. Poksay KS, Sheffler DJ, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. PMID: 28261092.
      View in: PubMed   Mentions:
    17. C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides. Tetrahedron Lett. 2016 May 11; 57(19):2059-2062. Alam MP, Jagodzinska B, Campagna J, Spilman P, John V. PMID: 27152054.
      View in: PubMed   Mentions:    Fields:    
    18. Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy. Int J Alzheimers Dis. 2016; 2016:8053139. Heinzelman P, Bilousova T, Campagna J, John V. PMID: 27213078.
      View in: PubMed   Mentions:
    19. Netrin-1 Interrupts Amyloid-ß Amplification, Increases sAßPPa in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 03 08; 52(1):223-42. Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. PMID: 27060954.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Correction to hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2015 Feb 26; 58(4):2045. Ellerby HM, Bredesen DE, Fujimura S, John V. PMID: 25668572.
      View in: PubMed   Mentions:    Fields:    
    21. sAßPPa is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis. 2015; 47(3):545-55. Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. PMID: 26401691.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    22. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617. Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. PMID: 24531152.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014 Mar 10; 1551:25-44. Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. PMID: 24389031.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8. Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. PMID: 24145446.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    25. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorg Med Chem Lett. 2013 Aug 15; 23(16):4674-9. Ng RA, Sun M, Bowers S, Hom RK, Probst GD, John V, Fang LY, Maillard M, Gailunas A, Brogley L, Neitz RJ, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Adler M, Yao N, Zmolek W, Nakamura D, Quinn KP, Sauer JM, Bova MP, Ruslim L, Artis DR, Yednock TA. PMID: 23856050.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    26. Next generation therapeutics for Alzheimer's disease. EMBO Mol Med. 2013 Jun; 5(6):795-8. Bredesen DE, John V. PMID: 23703924.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    27. AßPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. J Alzheimers Dis. 2013; 37(2):343-55. Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. PMID: 23948888.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    28. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012; 7(6):e40027. Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE. PMID: 22768208.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther. 2012 Jun 29; 4(3):22. Rao RV, Descamps O, John V, Bredesen DE. PMID: 22747839.
      View in: PubMed   Mentions: 20     Fields:    
    30. Pharmacological induction of neuroglobin expression. Pharmacology. 2011; 87(1-2):81-4. Jin K, Mao XO, Xie L, John V, Greenberg DA. PMID: 21228614.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    31. Induction of the C-terminal proteolytic cleavage of AßPP by statins. J Alzheimers Dis. 2011; 25(1):51-7. Descamps O, Zhang Q, John V, Bredesen DE. PMID: 21422530.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. Structural and functional alterations in amyloid-ß precursor protein induced by amyloid-ß peptides. J Alzheimers Dis. 2011; 25(3):547-66. Libeu CP, Poksay KS, John V, Bredesen DE. PMID: 21471643.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. Bioorg Med Chem Lett. 2010 Oct 15; 20(20):6034-9. Probst GD, Bowers S, Sealy JM, Stupi B, Dressen D, Jagodzinska BM, Aquino J, Gailunas A, Truong AP, Tso L, Xu YZ, Hom RK, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Sham HL, Jagodzinski J, Toth G, Brecht E, Yao N, Pan H, Lin M, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Gauby S, Zmolek W, Quinn KP, Sauer JM. PMID: 20822903.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    34. Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. Bioorg Med Chem Lett. 2010 Aug 15; 20(16):4789-94. Truong AP, Probst GD, Aquino J, Fang L, Brogley L, Sealy JM, Hom RK, Tucker JA, John V, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Tóth G, Yao N, Brecht E, Pan H, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Zmolek W, Quinn KP, Sauer JM. PMID: 20634069.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Importance of the caspase cleavage site in amyloid-ß protein precursor. J Alzheimers Dis. 2010; 22(1):57-63. Bredesen DE, John V, Galvan V. PMID: 20847422.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    36. Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorg Med Chem Lett. 2009 Nov 15; 19(22):6386-91. Sealy JM, Truong AP, Tso L, Probst GD, Aquino J, Hom RK, Jagodzinska BM, Dressen D, Wone DW, Brogley L, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Dappen MS, Toth G, Pan H, Ruslim L, Miller J, Bova MP, Sinha S, Quinn KP, Sauer JM. PMID: 19811916.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    37. Hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2008 Oct 09; 51(19):5887-92. Ellerby HM, Bredesen DE, Fujimura S, John V. PMID: 18828573.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    38. Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase. J Med Chem. 2007 Feb 22; 50(4):776-81. Maillard MC, Hom RK, Benson TE, Moon JB, Mamo S, Bienkowski M, Tomasselli AG, Woods DD, Prince DB, Paddock DJ, Emmons TL, Tucker JA, Dappen MS, Brogley L, Thorsett ED, Jewett N, Sinha S, John V. PMID: 17300163.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    39. Human beta-secretase (BACE) and BACE inhibitors: progress report. Curr Top Med Chem. 2006; 6(6):569-78. John V. PMID: 16712492.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    40. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase. J Med Chem. 2004 Jan 01; 47(1):158-64. Hom RK, Gailunas AF, Mamo S, Fang LY, Tung JS, Walker DE, Davis D, Thorsett ED, Jewett NE, Moon JB, John V. PMID: 14695829.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. Human beta-secretase (BACE) and BACE inhibitors. J Med Chem. 2003 Oct 23; 46(22):4625-30. John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL. PMID: 14561080.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    42. Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase. J Med Chem. 2003 May 08; 46(10):1799-802. Hom RK, Fang LY, Mamo S, Tung JS, Guinn AC, Walker DE, Davis DL, Gailunas AF, Thorsett ED, Sinha S, Knops JE, Jewett NE, Anderson JP, John V. PMID: 12723942.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    43. Design of substrate-based inhibitors of human beta-secretase. J Med Chem. 2002 Jan 17; 45(2):259-62. Tung JS, Davis DL, Anderson JP, Walker DE, Mamo S, Jewett N, Hom RK, Sinha S, Thorsett ED, John V. PMID: 11784130.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans