Loading...

John, Varghese

Title(s)Professor-in-Residence, Neurology
Phone64345
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    ApoE4-targeted therapeutics that normalize SirT1
    NIH/NIA R01AG051386Aug 1, 2019 - Mar 31, 2020
    Role: Principal Investigator
    Screening for enhancers of sAPPalpha
    NIH/NIA R21AG052195May 1, 2016 - Apr 30, 2018
    Role: Principal Investigator
    Screening for APPNeo Inhibitors
    NIH/NIA R21AG041456Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Heinzelman P, Powers DN, Wohlschlegel JA, John V. Shotgun Proteomic Profiling of Bloodborne Nanoscale Extracellular Vesicles. Methods Mol Biol. 2019; 1897:403-416. PMID: 30539460.
      View in: PubMed
    2. Duong AT, Simmons BJ, Alam MP, Campagna J, Garg NK, John V. Synthesis of Fused Indolines by Interrupted Fischer Indolization in a Microfluidic Reactor. Tetrahedron Lett. 2019 Jan 17; 60(3):322-326. PMID: 30631216.
      View in: PubMed
    3. Campagna J, Spilman P, Jagodzinska B, Bai D, Hatami A, Zhu C, Bilousova T, Jun M, Elias CJ, Pham J, Cole G, LaDu MJ, Jung ME, Bredesen DE, John V. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci Rep. 2018 12 04; 8(1):17574. PMID: 30514854.
      View in: PubMed
    4. Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, John V. Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol Biol. 2018 05 25; 430(11):1566-1576. PMID: 29649434.
      View in: PubMed
    5. Bilousova T, Elias C, Miyoshi E, Alam MP, Zhu C, Campagna J, Vadivel K, Jagodzinska B, Gylys KH, John V. Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem Biophys Res Commun. 2018 05 23; 499(4):751-757. PMID: 29604274.
      View in: PubMed
    6. Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 05; 77(5):760-769. PMID: 29436471.
      View in: PubMed
    7. Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D, John V. A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. ACS Chem Neurosci. 2018 03 21; 9(3):462-468. PMID: 29161500.
      View in: PubMed
    8. Subbiah N, Campagna J, Spilman P, Alam MP, Sharma S, Hokugo A, Nishimura I, John V. Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. J Drug Deliv. 2017; 2017:4759839. PMID: 28480080.
      View in: PubMed
    9. Poksay KS, Sheffler DJ, Spilman P, Campagna J, Jagodzinska B, Descamps O, Gorostiza O, Matalis A, Mullenix M, Bredesen DE, Cosford ND, John V. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production. Front Pharmacol. 2017; 8:46. PMID: 28261092.
      View in: PubMed
    10. Alam MP, Jagodzinska B, Campagna J, Spilman P, John V. C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides. Tetrahedron Lett. 2016 May 11; 57(19):2059-2062. PMID: 27152054.
      View in: PubMed
    11. Heinzelman P, Bilousova T, Campagna J, John V. Nanoscale Extracellular Vesicle Analysis in Alzheimer's Disease Diagnosis and Therapy. Int J Alzheimers Dis. 2016; 2016:8053139. PMID: 27213078.
      View in: PubMed
    12. Spilman PR, Corset V, Gorostiza O, Poksay KS, Galvan V, Zhang J, Rao R, Peters-Libeu C, Vincelette J, McGeehan A, Dvorak-Ewell M, Beyer J, Campagna J, Bankiewicz K, Mehlen P, John V, Bredesen DE. Netrin-1 Interrupts Amyloid-ß Amplification, Increases sAßPPa in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016 03 08; 52(1):223-42. PMID: 27060954.
      View in: PubMed
    13. Ellerby HM, Bredesen DE, Fujimura S, John V. Correction to hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2015 Feb 26; 58(4):2045. PMID: 25668572.
      View in: PubMed
    14. Peters-Libeu C, Campagna J, Mitsumori M, Poksay KS, Spilman P, Sabogal A, Bredesen DE, John V. sAßPPa is a Potent Endogenous Inhibitor of BACE1. J Alzheimers Dis. 2015; 47(3):545-55. PMID: 26401691.
      View in: PubMed
    15. Zhang Q, Descamps O, Hart MJ, Poksay KS, Spilman P, Kane DJ, Gorostiza O, John V, Bredesen DE. Paradoxical effect of TrkA inhibition in Alzheimer's disease models. J Alzheimers Dis. 2014; 40(3):605-617. PMID: 24531152.
      View in: PubMed
    16. Spilman P, Descamps O, Gorostiza O, Peters-Libeu C, Poksay KS, Matalis A, Campagna J, Patent A, Rao R, John V, Bredesen DE. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model. Brain Res. 2014 Mar 10; 1551:25-44. PMID: 24389031.
      View in: PubMed
    17. Theendakara V, Patent A, Peters Libeu CA, Philpot B, Flores S, Descamps O, Poksay KS, Zhang Q, Cailing G, Hart M, John V, Rao RV, Bredesen DE. Neuroprotective Sirtuin ratio reversed by ApoE4. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18303-8. PMID: 24145446.
      View in: PubMed
    18. Ng RA, Sun M, Bowers S, Hom RK, Probst GD, John V, Fang LY, Maillard M, Gailunas A, Brogley L, Neitz RJ, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Adler M, Yao N, Zmolek W, Nakamura D, Quinn KP, Sauer JM, Bova MP, Ruslim L, Artis DR, Yednock TA. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorg Med Chem Lett. 2013 Aug 15; 23(16):4674-9. PMID: 23856050.
      View in: PubMed
    19. Bredesen DE, John V. Next generation therapeutics for Alzheimer's disease. EMBO Mol Med. 2013 Jun; 5(6):795-8. PMID: 23703924.
      View in: PubMed
    20. Descamps O, Spilman P, Zhang Q, Libeu CP, Poksay K, Gorostiza O, Campagna J, Jagodzinska B, Bredesen DE, John V. AßPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. J Alzheimers Dis. 2013; 37(2):343-55. PMID: 23948888.
      View in: PubMed
    21. Libeu CA, Descamps O, Zhang Q, John V, Bredesen DE. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012; 7(6):e40027. PMID: 22768208.
      View in: PubMed
    22. Rao RV, Descamps O, John V, Bredesen DE. Ayurvedic medicinal plants for Alzheimer's disease: a review. Alzheimers Res Ther. 2012 Jun 29; 4(3):22. PMID: 22747839.
      View in: PubMed
    23. Libeu CP, Poksay KS, John V, Bredesen DE. Structural and functional alterations in amyloid-ß precursor protein induced by amyloid-ß peptides. J Alzheimers Dis. 2011; 25(3):547-66. PMID: 21471643.
      View in: PubMed
    24. Descamps O, Zhang Q, John V, Bredesen DE. Induction of the C-terminal proteolytic cleavage of AßPP by statins. J Alzheimers Dis. 2011; 25(1):51-7. PMID: 21422530.
      View in: PubMed
    25. Probst GD, Bowers S, Sealy JM, Stupi B, Dressen D, Jagodzinska BM, Aquino J, Gailunas A, Truong AP, Tso L, Xu YZ, Hom RK, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Sham HL, Jagodzinski J, Toth G, Brecht E, Yao N, Pan H, Lin M, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Gauby S, Zmolek W, Quinn KP, Sauer JM. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region. Bioorg Med Chem Lett. 2010 Oct 15; 20(20):6034-9. PMID: 20822903.
      View in: PubMed
    26. Truong AP, Probst GD, Aquino J, Fang L, Brogley L, Sealy JM, Hom RK, Tucker JA, John V, Tung JS, Pleiss MA, Konradi AW, Sham HL, Dappen MS, Tóth G, Yao N, Brecht E, Pan H, Artis DR, Ruslim L, Bova MP, Sinha S, Yednock TA, Zmolek W, Quinn KP, Sauer JM. Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents. Bioorg Med Chem Lett. 2010 Aug 15; 20(16):4789-94. PMID: 20634069.
      View in: PubMed
    27. Bredesen DE, John V, Galvan V. Importance of the caspase cleavage site in amyloid-ß protein precursor. J Alzheimers Dis. 2010; 22(1):57-63. PMID: 20847422.
      View in: PubMed
    28. Sealy JM, Truong AP, Tso L, Probst GD, Aquino J, Hom RK, Jagodzinska BM, Dressen D, Wone DW, Brogley L, John V, Tung JS, Pleiss MA, Tucker JA, Konradi AW, Dappen MS, Toth G, Pan H, Ruslim L, Miller J, Bova MP, Sinha S, Quinn KP, Sauer JM. Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents. Bioorg Med Chem Lett. 2009 Nov 15; 19(22):6386-91. PMID: 19811916.
      View in: PubMed
    29. Ellerby HM, Bredesen DE, Fujimura S, John V. Hunter-killer peptide (HKP) for targeted therapy. J Med Chem. 2008 Oct 09; 51(19):5887-92. PMID: 18828573.
      View in: PubMed
    30. Maillard MC, Hom RK, Benson TE, Moon JB, Mamo S, Bienkowski M, Tomasselli AG, Woods DD, Prince DB, Paddock DJ, Emmons TL, Tucker JA, Dappen MS, Brogley L, Thorsett ED, Jewett N, Sinha S, John V. Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase. J Med Chem. 2007 Feb 22; 50(4):776-81. PMID: 17300163.
      View in: PubMed
    31. John V. Human beta-secretase (BACE) and BACE inhibitors: progress report. Curr Top Med Chem. 2006; 6(6):569-78. PMID: 16712492.
      View in: PubMed
    32. Hom RK, Gailunas AF, Mamo S, Fang LY, Tung JS, Walker DE, Davis D, Thorsett ED, Jewett NE, Moon JB, John V. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase. J Med Chem. 2004 Jan 01; 47(1):158-64. PMID: 14695829.
      View in: PubMed
    33. John V, Beck JP, Bienkowski MJ, Sinha S, Heinrikson RL. Human beta-secretase (BACE) and BACE inhibitors. J Med Chem. 2003 Oct 23; 46(22):4625-30. PMID: 14561080.
      View in: PubMed
    34. Hom RK, Fang LY, Mamo S, Tung JS, Guinn AC, Walker DE, Davis DL, Gailunas AF, Thorsett ED, Sinha S, Knops JE, Jewett NE, Anderson JP, John V. Design and synthesis of statine-based cell-permeable peptidomimetic inhibitors of human beta-secretase. J Med Chem. 2003 May 08; 46(10):1799-802. PMID: 12723942.
      View in: PubMed
    35. Tung JS, Davis DL, Anderson JP, Walker DE, Mamo S, Jewett N, Hom RK, Sinha S, Thorsett ED, John V. Design of substrate-based inhibitors of human beta-secretase. J Med Chem. 2002 Jan 17; 45(2):259-62. PMID: 11784130.
      View in: PubMed