April Dawn Pyle

Title(s)Department Vice Chair, MIMG
SchoolMedicine
Emailapyle@mednet.ucla.edu
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    Other Positions
    Title(s)Professor, MIMG


    Collapse Biography 
    Collapse Awards and Honors
    UCLA2020  - PresGeorge and Nouhad Ayoub Centennial Chair for Life Science Innovation
    UCLA2015Rose Hills Foundation Scholar
    UCLA2018  - 2021Ablon Faculty Award
    UCLA2022Alfred E Mann Family Foundation Research Award
    UCLA2016Life Sciences Faculty Research Excellence Award UCLA

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering AAV Capsids for Transduction of Neural and Muscle Stem Cells
    CIRM CIRM DISC0-13765Jan 1, 2023 - Dec 31, 2025
    Enhancing Delivery of AAV-CRISPR to Muscle Stem Cells
    DOD DoD W81XWH2210756Sep 30, 2022 - Sep 29, 2024
    Role: PI
    Development of MyoDys45-55, a gene editing therapy for Duchenne muscular dystrophy
    CIRM CIRM TRAN1-12920Feb 1, 2022 - Jul 31, 2024
    Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs
    NIH R01AR064327Sep 20, 2013 - Nov 30, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Publisher Correction: Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells. Nat Cell Biol. 2024 Feb; 26(2):306. Hicks MR, Saleh KK, Clock B, Gibbs DE, Yang M, Younesi S, Gane L, Gutierrez-Garcia V, Xi H, Pyle AD. PMID: 38114737; PMCID: PMC10866700.
      View in: PubMed   Mentions:    Fields:    
    2. 'Enhancing' skeletal muscle and stem cells in three-dimensions: genome regulation of skeletal muscle in development and disease. Curr Opin Genet Dev. 2023 Dec; 83:102133. Romero MA, Pyle AD. PMID: 37951138; PMCID: PMC10872784.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells. Nat Cell Biol. 2023 Dec; 25(12):1758-1773. Hicks MR, Saleh KK, Clock B, Gibbs DE, Yang M, Younesi S, Gane L, Gutierrez-Garcia V, Xi H, Pyle AD. PMID: 37919520; PMCID: PMC10709143.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Nanoparticles systemically biodistribute to regenerating skeletal muscle in DMD. J Nanobiotechnology. 2023 Aug 29; 21(1):303. Hicks MR, Liu X, Young CS, Saleh K, Ji Y, Jiang J, Emami MR, Mokhonova E, Spencer MJ, Meng H, Pyle AD. PMID: 37641124; PMCID: PMC10463982.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs. Development. 2023 07 15; 150(14). Jaime OG, Arias J, Pavani S, Pyle AD, Hicks MR. PMID: 37366057; PMCID: PMC10357017.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy. Mol Ther Methods Clin Dev. 2023 Sep 14; 30:90-102. Emami MR, Espinoza A, Young CS, Ma F, Farahat PK, Felgner PL, Chamberlain JS, Xu X, Pyle AD, Pellegrini M, Villalta SA, Spencer MJ. PMID: 37746243; PMCID: PMC10512012.
      View in: PubMed   Mentions: 1  
    7. Muscle fusogens go viral for gene delivery to skeletal muscle. Cell. 2023 05 11; 186(10):2041-2043. Gibbs DE, Pyle AD. PMID: 37172560.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Duchenne muscular dystrophy disease severity impacts skeletal muscle progenitor cells systemic delivery. Front Physiol. 2023; 14:1190524. Saleh KK, Switzler C, Hicks MR, Gane L, Gibbs DE, Pyle AD. PMID: 37228827; PMCID: PMC10203213.
      View in: PubMed   Mentions: 3  
    9. Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis. NPJ Regen Med. 2023 Mar 15; 8(1):16. Stearns-Reider KM, Hicks MR, Hammond KG, Reynolds JC, Maity A, Kurmangaliyev YZ, Chin J, Stieg AZ, Geisse NA, Hohlbauch S, Kaemmer S, Schmitt LR, Pham TT, Yamauchi K, Novitch BG, Wollman R, Hansen KC, Pyle AD, Crosbie RH. PMID: 36922514; PMCID: PMC10017766.
      View in: PubMed   Mentions: 2  
    10. Single cell sequencing maps skeletal muscle cellular diversity as disease severity increases in dystrophic mouse models. iScience. 2022 Nov 18; 25(11):105415. Saleh KK, Xi H, Switzler C, Skuratovsky E, Romero MA, Chien P, Gibbs D, Gane L, Hicks MR, Spencer MJ, Pyle AD. PMID: 36388984; PMCID: PMC9646951.
      View in: PubMed   Mentions: 7  
    11. Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma. Nat Cancer. 2022 08; 3(8):961-975. Wei Y, Qin Q, Yan C, Hayes MN, Garcia SP, Xi H, Do D, Jin AH, Eng TC, McCarthy KM, Adhikari A, Onozato ML, Spentzos D, Neilsen GP, Iafrate AJ, Wexler LH, Pyle AD, Suvà ML, Dela Cruz F, Pinello L, Langenau DM. PMID: 35982179; PMCID: PMC10430812.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    12. The emergence of the stem cell niche. Trends Cell Biol. 2023 02; 33(2):112-123. Hicks MR, Pyle AD. PMID: 35934562; PMCID: PMC9868094.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. Recapitulating human myogenesis ex vivo using human pluripotent stem cells. Exp Cell Res. 2022 02 15; 411(2):112990. Chien P, Xi H, Pyle AD. PMID: 34973262; PMCID: PMC8996775.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. CRISPR-Mediated Genomic Addition to CPS1 Deficient iPSCs is Insufficient to Restore Nitrogen Homeostasis. Yale J Biol Med. 2021 12; 94(4):545-557. Nitzahn M, Truong B, Khoja S, Vega-Crespo A, Le C, Eliav A, Makris G, Pyle AD, Häberle J, Lipshutz GS. PMID: 34970092; PMCID: PMC8686786.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. NPJ Regen Med. 2021 Nov 23; 6(1):77. Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D. PMID: 34815400; PMCID: PMC8611001.
      View in: PubMed   Mentions: 4  
    16. Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nat Commun. 2021 05 10; 12(1):2595. Harn HI, Wang SP, Lai YC, Van Handel B, Liang YC, Tsai S, Schiessl IM, Sarkar A, Xi H, Hughes M, Kaemmer S, Tang MJ, Peti-Peterdi J, Pyle AD, Woolley TE, Evseenko D, Jiang TX, Chuong CM. PMID: 33972536; PMCID: PMC8110808.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. Generation of PAX7 Reporter Cells to Investigate Skeletal Myogenesis from Human Pluripotent Stem Cells. STAR Protoc. 2020 Dec 18; 1(3):100158. Xi H, Young CS, Pyle AD. PMID: 33377052; PMCID: PMC7757361.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy. Cell Rep Med. 2020 10 20; 1(7):100122. Liu J, Campagna J, John V, Damoiseaux R, Mokhonova E, Becerra D, Meng H, McNally EM, Pyle AD, Kramerova I, Spencer MJ. PMID: 33205074; PMCID: PMC7659555.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    19. Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells. Mol Ther Nucleic Acids. 2020 Dec 04; 22:500-509. Sengupta K, Mishra MK, Loro E, Spencer MJ, Pyle AD, Khurana TS. PMID: 33230452; PMCID: PMC7554652.
      View in: PubMed   Mentions: 10  
    20. A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. Cell Stem Cell. 2020 Jul 02; 27(1):181-185. Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD. PMID: 32619514; PMCID: PMC9012334.
      View in: PubMed   Mentions: 21     Fields:    
    21. A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. Cell Stem Cell. 2020 07 02; 27(1):158-176.e10. Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD. PMID: 32396864; PMCID: PMC7367475.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    22. Non-fibro-adipogenic pericytes from human embryonic stem cells attenuate degeneration of the chronically injured mouse muscle. JCI Insight. 2019 12 19; 4(24). Mosich GM, Husman R, Shah P, Sharma A, Rezzadeh K, Aderibigbe T, Hu VJ, McClintick DJ, Wu G, Gatto JD, Xi H, Pyle AD, Péault B, Petrigliano FA, Dar A. PMID: 31852842; PMCID: PMC6975261.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Beyond the genome: RNA control of stem cells. Science. 2019 11 08; 366(6466):684-685. Xi H, Pyle A. PMID: 31699921; PMCID: PMC7288777.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. A customizable microfluidic platform for medium-throughput modeling of neuromuscular circuits. Biomaterials. 2019 12; 225:119537. Bellmann J, Goswami RY, Girardo S, Rein N, Hosseinzadeh Z, Hicks MR, Busskamp V, Pyle AD, Werner C, Sterneckert J. PMID: 31614290; PMCID: PMC7294901.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. CRISPR for Neuromuscular Disorders: Gene Editing and Beyond. Physiology (Bethesda). 2019 09 01; 34(5):341-353. Young CS, Pyle AD, Spencer MJ. PMID: 31389773; PMCID: PMC6863376.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    26. Correction to: Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2019 Feb 12; 10(1):52. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. PMID: 30755264; PMCID: PMC6373121.
      View in: PubMed   Mentions:    Fields:    
    27. Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nat Commun. 2018 09 07; 9(1):3634. Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. PMID: 30194383; PMCID: PMC6128860.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Suicide Prevention for School Communities: An Educational Initiative for Student Safety. NASN Sch Nurse. 2018 May; 33(3):168-176. Roberts DC, Taylor ME, Pyle AD. PMID: 29658849.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    29. ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol. 2018 01; 20(1):46-57. Hicks MR, Hiserodt J, Paras K, Fujiwara W, Eskin A, Jan M, Xi H, Young CS, Evseenko D, Nelson SF, Spencer MJ, Handel BV, Pyle AD. PMID: 29255171; PMCID: PMC5962356.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    30. Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization. Stem Cell Res Ther. 2017 10 02; 8(1):217. Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS. PMID: 28969679; PMCID: PMC5625837.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    31. In Vivo Human Somitogenesis Guides Somite Development from hPSCs. Cell Rep. 2017 02 07; 18(6):1573-1585. Xi H, Fujiwara W, Gonzalez K, Jan M, Liebscher S, Van Handel B, Schenke-Layland K, Pyle AD. PMID: 28178531; PMCID: PMC5327729.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    32. Creation of a Novel Humanized Dystrophic Mouse Model of Duchenne Muscular Dystrophy and Application of a CRISPR/Cas9 Gene Editing Therapy. J Neuromuscul Dis. 2017; 4(2):139-145. Young CS, Mokhonova E, Quinonez M, Pyle AD, Spencer MJ. PMID: 28505980; PMCID: PMC5565771.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    33. Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells. Mol Ther Nucleic Acids. 2016 Nov 29; 5(11):e394. Lee PC, Truong B, Vega-Crespo A, Gilmore WB, Hermann K, Angarita SA, Tang JK, Chang KM, Wininger AE, Lam AK, Schoenberg BE, Cederbaum SD, Pyle AD, Byrne JA, Lipshutz GS. PMID: 27898091; PMCID: PMC5155330.
      View in: PubMed   Mentions: 17  
    34. Exon Skipping Therapy. Cell. 2016 Nov 17; 167(5):1144. Young CS, Pyle AD. PMID: 27863231.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    35. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell. 2016 Apr 07; 18(4):533-40. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. PMID: 26877224; PMCID: PMC4826286.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansAnimalsCells
    36. REST/NRSF Knockdown Alters Survival, Lineage Differentiation and Signaling in Human Embryonic Stem Cells. PLoS One. 2015; 10(12):e0145280. Thakore-Shah K, Koleilat T, Jan M, John A, Pyle AD. PMID: 26690059; PMCID: PMC4699193.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    37. The Path from Pluripotency to Skeletal Muscle: Developmental Myogenesis Guides the Way. Cell Stem Cell. 2015 Sep 03; 17(3):255-7. Hicks M, Pyle A. PMID: 26340524; PMCID: PMC4940037.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells. Small. 2015 Jun 03; 11(21):2499-504. Hou S, Choi JS, Chen KJ, Zhang Y, Peng J, Garcia MA, Yu JH, Thakore-Shah K, Ro T, Chen JF, Peyda P, Fan G, Pyle AD, Wang H, Tseng HR. PMID: 25613059; PMCID: PMC4961214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. Molecular recognition enables nanosubstrate-mediated delivery of gene-encapsulated nanoparticles with high efficiency. ACS Nano. 2014 May 27; 8(5):4621-9. Peng J, Garcia MA, Choi JS, Zhao L, Chen KJ, Bernstein JR, Peyda P, Hsiao YS, Liu KW, Lin WY, Pyle AD, Wang H, Hou S, Tseng HR. PMID: 24708312; PMCID: PMC4046775.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    40. Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status. Stem Cell Res Ther. 2013 Jul 26; 4(4):87. Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA. PMID: 23890092; PMCID: PMC3854769.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    41. Small molecule screening with laser cytometry can be used to identify pro-survival molecules in human embryonic stem cells. PLoS One. 2013; 8(1):e54948. Sherman SP, Pyle AD. PMID: 23383009; PMCID: PMC3558484.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    42. Insights into skeletal muscle development and applications in regenerative medicine. Int Rev Cell Mol Biol. 2013; 300:51-83. Tran T, Andersen R, Sherman SP, Pyle AD. PMID: 23273859.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. J Virol. 2013 Feb; 87(4):2094-108. Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B. PMID: 23192877; PMCID: PMC3571488.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    44. Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition. Small. 2013 Mar 11; 9(5):697-704. Yanes RE, Tarn D, Hwang AA, Ferris DP, Sherman SP, Thomas CR, Lu J, Pyle AD, Zink JI, Tamanoi F. PMID: 23152124; PMCID: PMC3767416.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    45. A spatially and chemically defined platform for the uniform growth of human pluripotent stem cells. Mater Sci Eng C Mater Biol Appl. 2013 Jan 01; 33(1):234-41. Jonas SJ, Alva JA, Richardson W, Sherman SP, Galic Z, Pyle AD, Dunn B. PMID: 25428067; PMCID: PMC4247494.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    46. From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols. Stem Cells Transl Med. 2012 Jan; 1(1):36-43. Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE. PMID: 23197638; PMCID: PMC3727693.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    47. Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells. Stem Cells. 2011 Dec; 29(12):1952-62. Alva JA, Lee GE, Escobar EE, Pyle AD. PMID: 21948699; PMCID: PMC3898662.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    48. Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell Stem Cell. 2011 Jan 07; 8(1):59-71. Le Belle JE, Orozco NM, Paucar AA, Saxe JP, Mottahedeh J, Pyle AD, Wu H, Kornblum HI. PMID: 21211782; PMCID: PMC3018289.
      View in: PubMed   Mentions: 368     Fields:    Translation:HumansAnimalsCells
    49. Human pluripotent stem cells: the development of high-content screening strategies. Methods Mol Biol. 2011; 767:283-95. Sherman SP, Alva JA, Thakore-Shah K, Pyle AD. PMID: 21822883.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. Female human iPSCs retain an inactive X chromosome. Cell Stem Cell. 2010 Sep 03; 7(3):329-42. Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. PMID: 20727844; PMCID: PMC2935700.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    51. Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells. PLoS One. 2010 Jul 16; 5(7):e11590. Tseng HC, Arasteh A, Paranjpe A, Teruel A, Yang W, Behel A, Alva JA, Walter G, Head C, Ishikawa TO, Herschman HR, Cacalano N, Pyle AD, Park NH, Jewett A. PMID: 20661281; PMCID: PMC2905395.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    52. Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions. Lab Chip. 2010 May 07; 10(9):1113-9. Kamei K, Ohashi M, Gschweng E, Ho Q, Suh J, Tang J, For Yu ZT, Clark AT, Pyle AD, Teitell MA, Lee KB, Witte ON, Tseng HR. PMID: 20390128; PMCID: PMC2970622.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    53. Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet. 2009 Jul; 5(7):e1000559. Zeng W, de Greef JC, Chen YY, Chien R, Kong X, Gregson HC, Winokur ST, Pyle A, Robertson KD, Schmiesing JA, Kimonis VE, Balog J, Frants RR, Ball AR, Lock LF, Donovan PJ, van der Maarel SM, Yokomori K. PMID: 19593370; PMCID: PMC2700282.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    54. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell. 2009 Jul 02; 5(1):111-23. Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K, Lowry WE. PMID: 19570518; PMCID: PMC3448781.
      View in: PubMed   Mentions: 461     Fields:    Translation:HumansAnimalsCells
    55. Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells. Stem Cells. 2009 Mar; 27(3):533-542. Damoiseaux R, Sherman SP, Alva JA, Peterson C, Pyle AD. PMID: 19074420; PMCID: PMC3962308.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    56. A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem Cells. 2009 Jan; 27(1):18-28. Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark AT. PMID: 19224508; PMCID: PMC3194037.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    57. Copy number variant analysis of human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1484-9. Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. PMID: 18369100; PMCID: PMC3901366.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    58. Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1436-43. Hohenstein KA, Pyle AD, Chern JY, Lock LF, Donovan PJ. PMID: 18323409; PMCID: PMC3882114.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    59. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2883-8. Lowry WE, Richter L, Yachechko R, Pyle AD, Tchieu J, Sridharan R, Clark AT, Plath K. PMID: 18287077; PMCID: PMC2268554.
      View in: PubMed   Mentions: 433     Fields:    Translation:HumansCells
    60. Neurotrophins mediate human embryonic stem cell survival. Nat Biotechnol. 2006 Mar; 24(3):344-50. Pyle AD, Lock LF, Donovan PJ. PMID: 16444268.
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    61. Staining embryonic stem cells using monoclonal antibodies to stage-specific embryonic antigens. Methods Mol Biol. 2006; 325:207-24. Fenderson BA, De Miguel MP, Pyle AD, Donovan PJ. PMID: 16761728.
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    62. Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells. 2005 Nov-Dec; 23(10):1489-501. Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L. PMID: 16002782.
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    64. BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development. 2004 Jan; 131(1):131-42. Sharan SK, Pyle A, Coppola V, Babus J, Swaminathan S, Benedict J, Swing D, Martin BK, Tessarollo L, Evans JP, Flaws JA, Handel MA. PMID: 14660434.
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    66. Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress. Dev Biol. 2002 Sep 01; 249(1):85-95. Eaker S, Cobb J, Pyle A, Handel MA. PMID: 12217320.
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