Atsushi Nakano

Title(s)Professor, Molecular, Cell and Developmental Biology
SchoolCollege of Letters and Science
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    Other Positions
    Title(s)Professor, Medicine


    Collapse Research 
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    Metabolic regulation of heart formation
    NIH R01HL142801Jun 1, 2019 - May 31, 2023
    Role: Principal Investigator
    Hemogenic endocardium: contribution to the valvular tissue macrophages
    NIH R01HL127427Sep 1, 2016 - Jun 30, 2020
    Role: Principal Investigator
    Small molecule screening for novel regulators of cardiac Ca2+ kinetics and rhythm
    NIH R56HL126051Sep 8, 2015 - Aug 31, 2017
    Role: Principal Investigator
    The role of electromechanical cue on cardiomyocyte maturation
    NIH R21HL124503Aug 10, 2015 - Jul 31, 2018
    Role: Principal Investigator
    The heart as a hemogenic organ
    NIH R21HL109938Aug 5, 2011 - May 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A crucial new aspect of cardiac morphogenesis: endocardial hematopoiesis. Front Physiol. 2024; 15:1525985. Liu N, Nakano A. PMID: 39720314; PMCID: PMC11667111.
      View in: PubMed   Mentions:
    2. Human formin FHOD3-mediated actin elongation is required for sarcomere integrity in cardiomyocytes. bioRxiv. 2024 Oct 14. Valencia DA, Koeberlein AN, Nakano H, Rudas A, Harui A, Spencer C, Nakano A, Quinlan ME. PMID: 39464085; PMCID: PMC11507729.
      View in: PubMed   Mentions:
    3. The role of metabolism in cardiac development. Curr Top Dev Biol. 2024; 156:201-243. Nakano H, Nakano A. PMID: 38556424.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy. Cell. 2024 01 04; 187(1):204-215.e14. Perez-Ramirez CA, Nakano H, Law RC, Matulionis N, Thompson J, Pfeiffer A, Park JO, Nakano A, Christofk HR. PMID: 38070508; PMCID: PMC10843853.
      View in: PubMed   Mentions: 5     Fields:    
    5. Rtf1-dependent transcriptional pausing regulates cardiogenesis. bioRxiv. 2023 Oct 15. Langenbacher AD, Lu F, Tsang L, Huang ZYS, Keer B, Tian Z, Eide A, Pellegrini M, Nakano H, Nakano A, Chen JN. PMID: 37873297; PMCID: PMC10592831.
      View in: PubMed   Mentions:
    6. Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5. Nat Commun. 2023 09 05; 14(1):5398. Liu N, Kawahira N, Nakashima Y, Nakano H, Iwase A, Uchijima Y, Wang M, Wu SM, Minamisawa S, Kurihara H, Nakano A. PMID: 37669937; PMCID: PMC10480477.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    7. Response to Matters Arising: Intercellular genetic tracing of cardiac endothelium in the developing heart. Dev Cell. 2023 08 21; 58(16):1513-1514. Nakano A, Liu N. PMID: 37348504; PMCID: PMC10765415.
      View in: PubMed   Mentions: 1     Fields:    
    8. Changes in macrophage immunometabolism as a marker of skeletal muscle dysfunction across the lifespan. Aging (Albany NY). 2023 05 25; 15(10):4035-4050. Liu N, Butcher JT, Nakano A, Del Campo A. PMID: 37244285; PMCID: PMC10258037.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. A novel murine model of atrial fibrillation by diphtheria toxin-induced injury. Front Physiol. 2022; 13:977735. Trieu T, Mach P, Bunn K, Huang V, Huang J, Chow C, Nakano H, Fajardo VM, Touma M, Ren S, Wang Y, Nakano A. PMID: 36388109; PMCID: PMC9659601.
      View in: PubMed   Mentions:
    10. Cardio PyMEA: A user-friendly, open-source Python application for cardiomyocyte microelectrode array analysis. PLoS One. 2022; 17(5):e0266647. Dunham CS, Mackenzie ME, Nakano H, Kim AR, Nakano A, Stieg AZ, Gimzewski JK. PMID: 35617323; PMCID: PMC9135279.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    11. Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures. PLoS One. 2022; 17(3):e0263976. Dunham CS, Mackenzie ME, Nakano H, Kim AR, Juda MB, Nakano A, Stieg AZ, Gimzewski JK. PMID: 35286321; PMCID: PMC8920264.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    12. Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome. J Mol Med (Berl). 2021 11; 99(11):1623-1638. Zhao Y, Wang LK, Eskin A, Kang X, Fajardo VM, Mehta Z, Pineles S, Schmidt RJ, Nagiel A, Satou G, Garg M, Federman M, Reardon LC, Lee SL, Biniwale R, Grody WW, Halnon N, Khanlou N, Quintero-Rivera F, Alejos JC, Nakano A, Fishbein GA, Van Arsdell GS, Nelson SF, Touma M. PMID: 34387706; PMCID: PMC8541947.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes Cells. 2021 Aug; 26(8):611-626. Harada Y, Tanaka T, Arai Y, Isomoto Y, Nakano A, Nakao S, Urasaki A, Watanabe Y, Kawamura T, Nakagawa O. PMID: 34081835.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep. 2021 04 21; 11(1):8669. Fajardo VM, Feng I, Chen BY, Perez-Ramirez CA, Shi B, Clark P, Tian R, Lien CL, Pellegrini M, Christofk H, Nakano H, Nakano A. PMID: 33883682; PMCID: PMC8060418.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    15. The role of glucose in physiological and pathological heart formation. Dev Biol. 2021 07; 475:222-233. Nakano H, Fajardo VM, Nakano A. PMID: 33577830; PMCID: PMC8107118.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    16. Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. J Biol Chem. 2020 12 18; 295(51):17632-17645. Watanabe Y, Seya D, Ihara D, Ishii S, Uemoto T, Kubo A, Arai Y, Isomoto Y, Nakano A, Abe T, Shigeta M, Kawamura T, Saito Y, Ogura T, Nakagawa O. PMID: 33454003; PMCID: PMC7762959.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells. Proc Natl Acad Sci U S A. 2020 06 23; 117(25):14522-14531. Anderson A, Masuho I, Marron Fernandez de Velasco E, Nakano A, Birnbaumer L, Martemyanov KA, Wickman K. PMID: 32513692; PMCID: PMC7322085.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Dev Biol. 2020 05 15; 461(2):124-131. Ihara D, Watanabe Y, Seya D, Arai Y, Isomoto Y, Nakano A, Kubo A, Ogura T, Kawamura T, Nakagawa O. PMID: 32035085.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    19. Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Dev Cell. 2019 03 11; 48(5):617-630.e3. Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. PMID: 30799229; PMCID: PMC6440481.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    20. Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis. Front Physiol. 2018; 9:943. Lee SW, Anderson A, Guzman PA, Nakano A, Tolkacheva EG, Wickman K. PMID: 30072916; PMCID: PMC6060443.
      View in: PubMed   Mentions: 17  
    21. Expression and relevance of the G protein-gated K+ channel in the mouse ventricle. Sci Rep. 2018 01 19; 8(1):1192. Anderson A, Kulkarni K, Marron Fernandez de Velasco E, Carlblom N, Xia Z, Nakano A, Martemyanov KA, Tolkacheva EG, Wickman K. PMID: 29352184; PMCID: PMC5775354.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. TRIM28-Regulated Transposon Repression Is Required for Human Germline Competency and Not Primed or Naive Human Pluripotency. Stem Cell Reports. 2018 01 09; 10(1):243-256. Tao Y, Yen MR, Chitiashvili T, Nakano H, Kim R, Hosohama L, Tan YC, Nakano A, Chen PY, Clark AT. PMID: 29290627; PMCID: PMC5768987.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 12 12; 6. Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. PMID: 29231167; PMCID: PMC5726851.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    24. Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep. 2017 03 07; 7:43210. Zhu H, Scharnhorst KS, Stieg AZ, Gimzewski JK, Minami I, Nakatsuji N, Nakano H, Nakano A. PMID: 28266620; PMCID: PMC5339708.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution. Sci Rep. 2017 02 06; 7:42209. Ding Y, Lee J, Ma J, Sung K, Yokota T, Singh N, Dooraghi M, Abiri P, Wang Y, Kulkarni RP, Nakano A, Nguyen TP, Fei P, Hsiai TK. PMID: 28165052; PMCID: PMC5292685.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    26. Simplified three-dimensional tissue clearing and incorporation of colorimetric phenotyping. Sci Rep. 2016 08 08; 6:30736. Sung K, Ding Y, Ma J, Chen H, Huang V, Cheng M, Yang CF, Kim JT, Eguchi D, Di Carlo D, Hsiai TK, Nakano A, Kulkarni RP. PMID: 27498769; PMCID: PMC4976371.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    27. A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells. Cell Stem Cell. 2016 Apr 07; 18(4):533-40. Young CS, Hicks MR, Ermolova NV, Nakano H, Jan M, Younesi S, Karumbayaram S, Kumagai-Cresse C, Wang D, Zack JA, Kohn DB, Nakano A, Nelson SF, Miceli MC, Spencer MJ, Pyle AD. PMID: 26877224; PMCID: PMC4826286.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    28. The developmental origins and lineage contributions of endocardial endothelium. Biochim Biophys Acta. 2016 Jul; 1863(7 Pt B):1937-47. Nakano A, Nakano H, Smith KA, Palpant NJ. PMID: 26828773.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    29. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016 Jan 01; 310(1):H92-103. Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S. PMID: 26519028.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    30. Hematopoietic progenitors are required for proper development of coronary vasculature. J Mol Cell Cardiol. 2015 Sep; 86:199-207. Lluri G, Huang V, Touma M, Liu X, Harmon AW, Nakano A. PMID: 26241844; PMCID: PMC4558312.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    31. Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor. FASEB J. 2015 Aug; 29(8):3342-56. Yamamoto K, Kakino A, Takeshita H, Hayashi N, Li L, Nakano A, Hanasaki-Yamamoto H, Fujita Y, Imaizumi Y, Toyama-Yokoyama S, Nakama C, Kawai T, Takeda M, Hongyo K, Oguro R, Maekawa Y, Itoh N, Takami Y, Onishi M, Takeya Y, Sugimoto K, Kamide K, Nakagami H, Ohishi M, Kurtz TW, Sawamura T, Rakugi H. PMID: 25877213.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    32. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ. PMID: 25870201; PMCID: PMC4419355.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    33. Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5. Nat Commun. 2015 Jan 30; 6:6137. Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S. PMID: 25635515; PMCID: PMC4317497.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    34. Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity. Elife. 2015 Jan 15; 4. Shimizu H, Schredelseker J, Huang J, Lu K, Naghdi S, Lu F, Franklin S, Fiji HD, Wang K, Zhu H, Tian C, Lin B, Nakano H, Ehrlich A, Nakai J, Stieg AZ, Gimzewski JK, Nakano A, Goldhaber JI, Vondriska TM, Hajnóczky G, Kwon O, Chen JN. PMID: 25588501; PMCID: PMC4293673.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    35. Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system. Circ Res. 2014 Mar 28; 114(7):1103-13. Nakashima Y, Yanez DA, Touma M, Nakano H, Jaroszewicz A, Jordan MC, Pellegrini M, Roos KP, Nakano A. PMID: 24563458.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    36. Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):273-8. Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y, Takashima S. PMID: 24344269; PMCID: PMC3890790.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    37. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013; 8(11):e81633. Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. PMID: 24278453; PMCID: PMC3836769.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    38. Nkx2-5 lineage tracing visualizes the distribution of second heart field-derived aortic smooth muscle. Genesis. 2013 Dec; 51(12):862-9. Harmon AW, Nakano A. PMID: 24133047; PMCID: PMC3943338.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    39. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci Technol Adv Mater. 2013 Aug 01; 14(2). Arshi A, Nakashima Y, Nakano H, Eaimkhong S, Evseenko D, Reed J, Stieg AZ, Gimzewski JK, Nakano A. PMID: 24311969; PMCID: PMC3845966.
      View in: PubMed   Mentions: 21  
    40. Intrauterine calorie restriction affects placental DNA methylation and gene expression. Physiol Genomics. 2013 Jul 15; 45(14):565-76. Chen PY, Ganguly A, Rubbi L, Orozco LD, Morselli M, Ashraf D, Jaroszewicz A, Feng S, Jacobsen SE, Nakano A, Devaskar SU, Pellegrini M. PMID: 23695884; PMCID: PMC3727019.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    41. Haemogenic endocardium contributes to transient definitive haematopoiesis. Nat Commun. 2013; 4:1564. Nakano H, Liu X, Arshi A, Nakashima Y, van Handel B, Sasidharan R, Harmon AW, Shin JH, Schwartz RJ, Conway SJ, Harvey RP, Pashmforoush M, Mikkola HK, Nakano A. PMID: 23463007; PMCID: PMC3612528.
      View in: PubMed   Mentions: 85     Fields:    Translation:AnimalsCells
    42. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 03; 150(3):590-605. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. PMID: 22863011; PMCID: PMC3624753.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    43. Cardiac origin of smooth muscle cells in the inflow tract. J Mol Cell Cardiol. 2011 Feb; 50(2):337-45. Nakano H, Williams E, Hoshijima M, Sasaki M, Minamisawa S, Chien KR, Nakano A. PMID: 20974149; PMCID: PMC3031779.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    44. Identification of genes related to heart failure using global gene expression profiling of human failing myocardium. Biochem Biophys Res Commun. 2010 Feb 26; 393(1):55-60. Min KD, Asakura M, Liao Y, Nakamaru K, Okazaki H, Takahashi T, Fujimoto K, Ito S, Takahashi A, Asanuma H, Yamazaki S, Minamino T, Sanada S, Seguchi O, Nakano A, Ando Y, Otsuka T, Furukawa H, Isomura T, Takashima S, Mochizuki N, Kitakaze M. PMID: 20100464.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    45. Islet1 cardiovascular progenitors: a single source for heart lineages? Development. 2008 Jan; 135(2):193-205. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. PMID: 18156162.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    46. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell. 2006 Dec 15; 127(6):1151-65. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. PMID: 17123592.
      View in: PubMed   Mentions: 467     Fields:    Translation:AnimalsCells
    47. The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. Dev Biol. 2006 Jun 15; 294(2):458-70. Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T. PMID: 16678147.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
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