Margot Elizabeth Quinlan

Title(s)Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
ORCID ORCID Icon0000-0002-8133-1033 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Reed College, Portland, ORB.A.09/1991Biology
    University of Pennsylvania, Philadelphia, PAPh.D.08/2002Cell and Molecular Biology

    Collapse Overview 
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    Collapse Research 
    Collapse Research Activities and Funding
    Harnessing genetic code expansion to measure in vivo actin dynamics
    NIH R21GM134473Sep 15, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Using formins to build distinct structures in cardiomyocytes
    NIH R01HL146159Sep 1, 2019 - Aug 31, 2023
    Role: Principal Investigator
    Collaboration between actin nucleators - Spire and Cappuccino
    NIH R01GM096133Sep 1, 2011 - Aug 31, 2025
    Role: Principal Investigator
    UCLA Maximizing Student Development (MSD) Program
    NIH R25GM055052Sep 30, 1996 - Feb 28, 2022
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Formin tails act as a switch, inhibiting or enhancing processive actin elongation. J Biol Chem. 2024 Jan; 300(1):105557. Bremer KV, Wu C, Patel AA, He KL, Grunfeld AM, Chanfreau GF, Quinlan ME. PMID: 38097186; PMCID: PMC10797183.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Formins. Curr Biol. 2021 05 24; 31(10):R517-R522. Valencia DA, Quinlan ME. PMID: 34033783.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    3. Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments. Mol Biol Cell. 2020 02 15; 31(4):273-286. Bradley AO, Vizcarra CL, Bailey HM, Quinlan ME. PMID: 31877067; PMCID: PMC7183766.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins. Curr Biol. 2018 05 21; 28(10):1536-1547.e9. Kudryashova E, Heisler DB, Williams B, Harker AJ, Shafer K, Quinlan ME, Kovar DR, Vavylonis D, Kudryashov DS. PMID: 29731300; PMCID: PMC5964048.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    5. The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongation. Mol Biol Cell. 2018 03 01; 29(5):610-621. Silkworth WT, Kunes KL, Nickel GC, Phillips ML, Quinlan ME, Vizcarra CL. PMID: 29282276; PMCID: PMC6004577.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    6. Drosophila and human FHOD family formin proteins nucleate actin filaments. J Biol Chem. 2018 01 12; 293(2):532-540. Patel AA, Oztug Durer ZA, van Loon AP, Bremer KV, Quinlan ME. PMID: 29127202; PMCID: PMC5767859.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    7. Actin filament assembly by bacterial factors VopL/F: Which end is up? J Cell Biol. 2017 05 01; 216(5):1211-1213. Vizcarra CL, Quinlan ME. PMID: 28416477; PMCID: PMC5412575.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    8. Cytoplasmic Streaming in the Drosophila Oocyte. Annu Rev Cell Dev Biol. 2016 10 06; 32:173-195. Quinlan ME. PMID: 27362645.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    9. Metavinculin Tunes the Flexibility and the Architecture of Vinculin-Induced Bundles of Actin Filaments. J Mol Biol. 2015 Aug 28; 427(17):2782-98. Oztug Durer ZA, McGillivary RM, Kang H, Elam WA, Vizcarra CL, Hanein D, De La Cruz EM, Reisler E, Quinlan ME. PMID: 26168869; PMCID: PMC4540644.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    10. Drosophila Cappuccino alleles provide insight into formin mechanism and role in oogenesis. Mol Biol Cell. 2015 May 15; 26(10):1875-86. Yoo H, Roth-Johnson EA, Bor B, Quinlan ME. PMID: 25788286; PMCID: PMC4436832.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Regulation of the formin Cappuccino is critical for polarity of Drosophila oocytes. Cytoskeleton (Hoboken). 2015 Jan; 72(1):1-15. Bor B, Bois JS, Quinlan ME. PMID: 25557988; PMCID: PMC4361322.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes. J Infect Dis. 2015 Apr 01; 211(7):1185-95. Fattouh R, Kwon H, Czuczman MA, Copeland JW, Pelletier L, Quinlan ME, Muise AM, Higgins DE, Brumell JH. PMID: 25281757; PMCID: PMC4432431.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    13. The role of formin tails in actin nucleation, processive elongation, and filament bundling. J Biol Chem. 2014 Oct 31; 289(44):30602-30613. Vizcarra CL, Bor B, Quinlan ME. PMID: 25246531; PMCID: PMC4215239.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    14. Filament assembly by Spire: key residues and concerted actin binding. J Mol Biol. 2015 Feb 27; 427(4):824-839. Rasson AS, Bois JS, Pham DSL, Yoo H, Quinlan ME. PMID: 25234086; PMCID: PMC4324353.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    15. Interaction between microtubules and the Drosophila formin Cappuccino and its effect on actin assembly. J Biol Chem. 2014 Feb 14; 289(7):4395-404. Roth-Johnson EA, Vizcarra CL, Bois JS, Quinlan ME. PMID: 24362037; PMCID: PMC3924302.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    16. Direct interaction between two actin nucleators is required in Drosophila oogenesis. Development. 2013 Nov; 140(21):4417-25. Quinlan ME. PMID: 24089467; PMCID: PMC4007717.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    17. Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains. Mol Biol Cell. 2012 Oct; 23(19):3801-13. Bor B, Vizcarra CL, Phillips ML, Quinlan ME. PMID: 22875983; PMCID: PMC3459857.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    18. The acquisition and analysis of polarized total internal reflection fluorescence microscopy (polTIRFM) data. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):722-5. Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22661430; PMCID: PMC3855859.
      View in: PubMed   Mentions: 4     Fields:    
    19. Construction of flow chambers for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):712-5. Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22661445; PMCID: PMC3855857.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    20. The polarized total internal reflection fluorescence microscopy (polTIRFM) twirling filament assay. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):719-21. Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22661429; PMCID: PMC3852181.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    21. The polarized total internal reflection fluorescence microscopy (polTIRFM) processive motility assay for myosin V. Cold Spring Harb Protoc. 2012 Jun 01; 2012(6):716-8. Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22661446; PMCID: PMC3852403.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    22. Fluorescent labeling of calmodulin with bifunctional rhodamine. Cold Spring Harb Protoc. 2012 May 01; 2012(5). Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22550304; PMCID: PMC3852408.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    23. Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy (polTIRFM). Cold Spring Harb Protoc. 2012 May 01; 2012(5). Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22550303; PMCID: PMC3855856.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    24. Preparation of filamentous actin for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays. Cold Spring Harb Protoc. 2012 May 01; 2012(5). Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22550306; PMCID: PMC3852664.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Fluorescent labeling of myosin V for polarized total internal reflection fluorescence microscopy (polTIRFM) motility assays. Cold Spring Harb Protoc. 2012 May 01; 2012(5). Beausang JF, Sun Y, Quinlan ME, Forkey JN, Goldman YE. PMID: 22550305; PMCID: PMC3855858.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. Multiple forms of Spire-actin complexes and their functional consequences. J Biol Chem. 2012 Mar 23; 287(13):10684-10692. Chen CK, Sawaya MR, Phillips ML, Reisler E, Quinlan ME. PMID: 22334675; PMCID: PMC3323035.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Structure and function of the interacting domains of Spire and Fmn-family formins. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11884-9. Vizcarra CL, Kreutz B, Rodal AA, Toms AV, Lu J, Zheng W, Quinlan ME, Eck MJ. PMID: 21730168; PMCID: PMC3141961.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    28. p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol. 2009 Apr; 11(4):451-9. Zuchero JB, Coutts AS, Quinlan ME, Thangue NB, Mullins RD. PMID: 19287377; PMCID: PMC2763628.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    29. Actin nucleation: bacteria get in-Spired. Nat Cell Biol. 2008 Jan; 10(1):13-5. Quinlan ME, Kerkhoff E. PMID: 18172428.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    30. Regulatory interactions between two actin nucleators, Spire and Cappuccino. J Cell Biol. 2007 Oct 08; 179(1):117-28. Quinlan ME, Hilgert S, Bedrossian A, Mullins RD, Kerkhoff E. PMID: 17923532; PMCID: PMC2064741.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    31. Rotational motions of macro-molecules by single-molecule fluorescence microscopy. Acc Chem Res. 2005 Jul; 38(7):583-93. Rosenberg SA, Quinlan ME, Forkey JN, Goldman YE. PMID: 16028893.
      View in: PubMed   Mentions: 40     Fields:    
    32. Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy. Biophys J. 2005 Aug; 89(2):1261-71. Forkey JN, Quinlan ME, Goldman YE. PMID: 15894632; PMCID: PMC1366610.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    33. Orientation of the myosin light chain region by single molecule total internal reflection fluorescence polarization microscopy. Biophys J. 2005 Aug; 89(2):1132-42. Quinlan ME, Forkey JN, Goldman YE. PMID: 15894631; PMCID: PMC1366598.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    34. Drosophila Spire is an actin nucleation factor. Nature. 2005 Jan 27; 433(7024):382-8. Quinlan ME, Heuser JE, Kerkhoff E, Mullins RD. PMID: 15674283.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    35. Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization. Nature. 2003 Mar 27; 422(6930):399-404. Forkey JN, Quinlan ME, Shaw MA, Corrie JE, Goldman YE. PMID: 12660775.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    36. Kinesin-ADP: whole lotta shakin' goin' on. Nat Struct Biol. 2001 Jun; 8(6):478-80. Quinlan ME, Forkey JN, Goldman YE. PMID: 11373608.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    37. Protein structural dynamics by single-molecule fluorescence polarization. Prog Biophys Mol Biol. 2000; 74(1-2):1-35. Forkey JN, Quinlan ME, Goldman YE. PMID: 11106805.
      View in: PubMed   Mentions: 30     Fields:    
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