Profiles

Our laboratory investigates the functions of histones in regulation of specific biological processes and their alterations in human disease using biochemical, genetic, molecular biological and high-throughput approaches. Although we are agnostic to model systems, we choose and employ one that is most appropriate for the question being asked. Presently, we use cancer cell lines, human and murine embryonic stem cells, primary human cancer tissues as well as the model organism, Saccharomyces cerevisiae, to study the basic biology and pathophysiology of histones. We seek and welcome collaborations that will mutually enrich and enhance research by expanding technical and intellectual repertoire. Our mission is to cultivate a culture of intellectual curiosity and experimental exploration unencumbered by perceived dogma. We take deliberate risks to enable inquiry into uncharted territories, yet practice within our scientific space in order to incur the funds necessary to move forward with our unique vision and speculations. We encourage imaginative, inspired and original thinking that produce new scientific narratives devoid of hyperbole and cynicism. As students of life sciences, we are enamored by the biology of chromatin and feel privileged to explore the perplexity of its structure for the pure joy of discovery and the betterment of society.