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Siavash K Kurdistani

Title(s)Department Chair, Biological Chemistry, Biological Chemistry
SchoolMedicine
Address760 Westwood Plaza 337
Los Angeles CA 90024
Phone45194, 51206
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    Other Positions
    Title(s)Professor, Biological Chemistry

    Title(s)Professor, Pathology and Laboratory Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Dynamics of Histone Acetylation in Cancer Cell Physiology
    NIH/NCI R01CA178415Sep 23, 2013 - Jul 31, 2018
    Role: Principal Investigator
    A Blueprint for Oncogenic Epigenetic Reprogramming
    NIH DP2OD006516Sep 30, 2009 - Jun 30, 2014
    Role: Principal Investigator
    UCLA-Caltech Medical Scientist Training Program
    NIH/NIGMS T32GM008042Jul 1, 1983 - Jun 30, 2024
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The histone H3-H4 tetramer is a copper reductase enzyme. Science. 2020 07 03; 369(6499):59-64. Attar N, Campos OA, Vogelauer M, Cheng C, Xue Y, Schmollinger S, Salwinski L, Mallipeddi NV, Boone BA, Yen L, Yang S, Zikovich S, Dardine J, Carey MF, Merchant SS, Kurdistani SK. PMID: 32631887.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    2. MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment. Nature. 2019 12; 576(7786):281-286. Calvanese V, Nguyen AT, Bolan TJ, Vavilina A, Su T, Lee LK, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA. PMID: 31776511.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods. Mol Cell. 2019 01 17; 73(2):250-263.e5. Sun F, Chronis C, Kronenberg M, Chen XF, Su T, Lay FD, Plath K, Kurdistani SK, Carey MF. PMID: 30527662.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. Science. 2018 10 05; 362(6410):91-95. Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON. PMID: 30287662.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    5. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. Elife. 2017 12 12; 6. Nakano H, Minami I, Braas D, Pappoe H, Wu X, Sagadevan A, Vergnes L, Fu K, Morselli M, Dunham C, Ding X, Stieg AZ, Gimzewski JK, Pellegrini M, Clark PM, Reue K, Lusis AJ, Ribalet B, Kurdistani SK, Christofk H, Nakatsuji N, Nakano A. PMID: 29231167.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    6. Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals. Mol Cell. 2017 Aug 17; 67(4):594-607.e4. Xue Y, Pradhan SK, Sun F, Chronis C, Tran N, Su T, Van C, Vashisht A, Wohlschlegel J, Peterson CL, Timmers HTM, Kurdistani SK, Carey MF. PMID: 28735899.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts. Oncotarget. 2017 Mar 21; 8(12):19074-19088. Nguyen AH, Elliott IA, Wu N, Matsumura C, Vogelauer M, Attar N, Dann A, Ghukasyan R, Toste PA, Patel SG, Williams JL, Li L, Dawson DW, Radu C, Kurdistani SK, Donahue TR. PMID: 27894105.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer. Cold Spring Harb Perspect Med. 2017 Mar 01; 7(3). Attar N, Kurdistani SK. PMID: 27881443.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    9. MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis. Nat Commun. 2016 08 10; 7:12376. Wang W, Org T, Montel-Hagen A, Pioli PD, Duan D, Israely E, Malkin D, Su T, Flach J, Kurdistani SK, Schiestl RH, Mikkola HK. PMID: 27507714.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    10. MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell Rep. 2016 Feb 23; 14(7):1590-1601. Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR. PMID: 26876179.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    11. EP400 Deposits H3.3 into Promoters and Enhancers during Gene Activation. Mol Cell. 2016 Jan 07; 61(1):27-38. Pradhan SK, Su T, Yen L, Jacquet K, Huang C, Côté J, Kurdistani SK, Carey MF. PMID: 26669263.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    12. The Ino80 complex prevents invasion of euchromatin into silent chromatin. Genes Dev. 2015 Feb 15; 29(4):350-5. Xue Y, Van C, Pradhan SK, Su T, Gehrke J, Kuryan BG, Kitada T, Vashisht A, Tran N, Wohlschlegel J, Peterson CL, Kurdistani SK, Carey MF. PMID: 25691465.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    13. Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J. 2015 Mar 12; 34(6):759-77. Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerényi MA, Sasidharan R, Rubbi L, Fujiwara Y, Pellegrini M, Orkin SH, Kurdistani SK, Mikkola HK. PMID: 25564442.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    14. Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology. Curr Opin Genet Dev. 2014 Jun; 26:53-8. Kurdistani SK. PMID: 25016437.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Evolution of histone 2A for chromatin compaction in eukaryotes. Elife. 2014 Jun 17; 3. Macadangdang BR, Oberai A, Spektor T, Campos OA, Sheng F, Carey MF, Vogelauer M, Kurdistani SK. PMID: 24939988.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    16. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    17. Histone deacetylase inhibitor sensitizes apoptosis-resistant melanomas to cytotoxic human T lymphocytes through regulation of TRAIL/DR5 pathway. J Immunol. 2014 Apr 15; 192(8):3981-9. Jazirehi AR, Kurdistani SK, Economou JS. PMID: 24639349.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    18. A unique epigenetic signature is associated with active DNA replication loci in human embryonic stem cells. Epigenetics. 2014 Feb; 9(2):257-67. Li B, Su T, Ferrari R, Li JY, Kurdistani SK. PMID: 24172870.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    19. Histone acetylation regulates intracellular pH. Mol Cell. 2013 Jan 24; 49(2):310-21. McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK. PMID: 23201122.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    20. Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function. Cell Rep. 2012 Nov 29; 2(5):1061-7. Chen XF, Lehmann L, Lin JJ, Vashisht A, Schmidt R, Ferrari R, Huang C, McKee R, Mosley A, Plath K, Kurdistani SK, Wohlschlegel J, Carey M. PMID: 23177621.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    21. Dynamic distribution of linker histone H1.5 in cellular differentiation. PLoS Genet. 2012; 8(8):e1002879. Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK. PMID: 22956909.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    22. Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes. J Biol Chem. 2012 Oct 19; 287(43):35784-94. Lehmann L, Ferrari R, Vashisht AA, Wohlschlegel JA, Kurdistani SK, Carey M. PMID: 22910904.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    23. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 03; 150(3):590-605. Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK. PMID: 22863011.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    24. Stimulation of histone deacetylase activity by metabolites of intermediary metabolism. J Biol Chem. 2012 Sep 14; 287(38):32006-16. Vogelauer M, Krall AS, McBrian MA, Li JY, Kurdistani SK. PMID: 22822071.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    25. Reorganization of the host epigenome by a viral oncogene. Genome Res. 2012 Jul; 22(7):1212-21. Ferrari R, Su T, Li B, Bonora G, Oberai A, Chan Y, Sasidharan R, Berk AJ, Pellegrini M, Kurdistani SK. PMID: 22499665.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    26. Enhancer dysfunction: how the main regulators of gene expression contribute to cancer. Genome Biol. 2012; 13(5):156. Kurdistani SK. PMID: 22621675.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. The Rpd3 core complex is a chromatin stabilization module. Curr Biol. 2012 Jan 10; 22(1):56-63. Chen XF, Kuryan B, Kitada T, Tran N, Li JY, Kurdistani S, Grunstein M, Li B, Carey M. PMID: 22177115.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    28. Histone modifications in cancer biology and prognosis. Prog Drug Res. 2011; 67:91-106. Kurdistani SK. PMID: 21141726.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    29. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol. 2010 Mar 10; 28(8):1358-65. Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, Kurdistani SK, Guha C, Dawson DW. PMID: 20142597.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    30. Viral manipulation of the host epigenome for oncogenic transformation. Nat Rev Genet. 2009 05; 10(5):290-4. Ferrari R, Berk AJ, Kurdistani SK. PMID: 19290008.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    31. Global levels of histone modifications predict prognosis in different cancers. Am J Pathol. 2009 May; 174(5):1619-28. Seligson DB, Horvath S, McBrian MA, Mah V, Yu H, Tze S, Wang Q, Chia D, Goodglick L, Kurdistani SK. PMID: 19349354.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansCells
    32. Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood. 2009 Apr 09; 113(15):3461-71. Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK. PMID: 19211936.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    33. Adenovirus small e1a alters global patterns of histone modification. Science. 2008 Aug 22; 321(5892):1084-5. Horwitz GA, Zhang K, McBrian MA, Grunstein M, Kurdistani SK, Berk AJ. PMID: 18719283.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    34. Epigenetic reprogramming by adenovirus e1a. Science. 2008 Aug 22; 321(5892):1086-8. Ferrari R, Pellegrini M, Horwitz GA, Xie W, Berk AJ, Kurdistani SK. PMID: 18719284.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    35. Regulators of cellular levels of histone acetylation in Saccharomyces cerevisiae. Genetics. 2008 May; 179(1):277-89. Peng W, Togawa C, Zhang K, Kurdistani SK. PMID: 18493053.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    36. Modeling the regulatory network of histone acetylation in Saccharomyces cerevisiae. Mol Syst Biol. 2007; 3:153. Pham H, Ferrari R, Cokus SJ, Kurdistani SK, Pellegrini M. PMID: 18091724.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. Histone modifications as markers of cancer prognosis: a cellular view. Br J Cancer. 2007 Jul 02; 97(1):1-5. Kurdistani SK. PMID: 17592497.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    38. Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell. 2005 Nov 18; 123(4):593-605. Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. PMID: 16286008.
      View in: PubMed   Mentions: 394     Fields:    Translation:AnimalsCells
    39. Global histone modification patterns predict risk of prostate cancer recurrence. Nature. 2005 Jun 30; 435(7046):1262-6. Seligson DB, Horvath S, Shi T, Yu H, Tze S, Grunstein M, Kurdistani SK. PMID: 15988529.
      View in: PubMed   Mentions: 321     Fields:    Translation:HumansCells
    40. Mapping global histone acetylation patterns to gene expression. Cell. 2004 Jun 11; 117(6):721-33. Kurdistani SK, Tavazoie S, Grunstein M. PMID: 15186774.
      View in: PubMed   Mentions: 238     Fields:    Translation:AnimalsCells
    41. Analysis of genome-wide histone acetylation state and enzyme binding using DNA microarrays. Methods Enzymol. 2004; 376:289-304. Robyr D, Kurdistani SK, Grunstein M. PMID: 14975313.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    42. In vivo protein-protein and protein-DNA crosslinking for genomewide binding microarray. Methods. 2003 Sep; 31(1):90-5. Kurdistani SK, Grunstein M. PMID: 12893178.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    43. Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol. 2003 Apr; 4(4):276-84. Kurdistani SK, Grunstein M. PMID: 12671650.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    44. Requirement of Hos2 histone deacetylase for gene activity in yeast. Science. 2002 Nov 15; 298(5597):1412-4. Wang A, Kurdistani SK, Grunstein M. PMID: 12434058.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    45. Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet. 2002 Jul; 31(3):248-54. Kurdistani SK, Robyr D, Tavazoie S, Grunstein M. PMID: 12089521.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    46. Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell. 2002 May 17; 109(4):437-46. Robyr D, Suka Y, Xenarios I, Kurdistani SK, Wang A, Suka N, Grunstein M. PMID: 12086601.
      View in: PubMed   Mentions: 174     Fields:    Translation:AnimalsCells
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