Gay M Crooks

Title(s)Professor, Pathology and Laboratory Medicine
SchoolMedicine
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    Other Positions
    Title(s)Professor, Orthopaedic Surgery

    Title(s)Professor, Pediatrics


    Collapse Research 
    Collapse Research Activities and Funding
    Targeting alternative splicing for TCR discovery in small cell carcinomas
    NIH U01CA233074Sep 21, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Discovery and manipulation of mesenchymal signals for thymic rejuvenation
    NIH R01AG049753Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    A novel thymic implant strategy to induce T cell reconstitution and immune tolerance for patients with complete DiGeorge Syndrome
    NIH R21AI119927Jul 1, 2015 - Jun 30, 2018
    Role: Principal Investigator
    Stem Cell Therapies for Primary Immune Deficiency
    NIH P01AI072686Jul 18, 2009 - Jun 30, 2012
    Role: Principal Investigator
    Enhancing immune reconstitution after implantation of postnatal allogeneic thymus
    NIH R21HL095165Sep 19, 2008 - Aug 31, 2010
    Role: Principal Investigator
    Cell cycle ontrol of B-cell mass
    NIH R01DK068719Jul 5, 2004 - Jun 30, 2007
    Role: Principal Investigator
    Transplantation biology of human lymphoid progenitors
    NIH R01HL077912Jul 1, 2004 - Jun 30, 2009
    Role: Principal Investigator
    TRANSDUCTION OF HUMAN HEMATOPOIETIC STEM CELLS
    NIH R01DK054567Jun 1, 1998 - May 31, 2003
    Role: Principal Investigator
    Tumor Cell Biology Training Program
    NIH T32CA009056Jul 1, 1980 - Jul 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity. J Clin Invest. 2022 08 15; 132(16). Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. PMID: 35653193; PMCID: PMC9374381.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2203410119. Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON. PMID: 35878026; PMCID: PMC9351518.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells. Cell Stem Cell. 2022 Apr 07; 29(4):651-653. Wang Z, McWilliams-Koeppen HP, Reza H, Ostberg JR, Chen W, Wang X, Huynh C, Vyas V, Chang WC, Starr R, Wagner JR, Aguilar B, Yang X, Wu X, Wang J, Chen W, Koelker-Wolfe E, Seet CS, Montel-Hagen A, Crooks GM, Forman SJ, Brown CE. PMID: 35395190.
      View in: PubMed   Mentions: 1     Fields:    
    4. Generation of Artificial Thymic Organoids from Human and Murine Hematopoietic Stem and Progenitor Cells. Curr Protoc. 2022 Apr; 2(4):e403. Montel-Hagen A, Tsai S, Seet CS, Crooks GM. PMID: 35384408.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells. Cell Stem Cell. 2022 04 07; 29(4):515-527.e8. Wang Z, McWilliams-Koeppen HP, Reza H, Ostberg JR, Chen W, Wang X, Huynh C, Vyas V, Chang WC, Starr R, Wagner JR, Aguilar B, Yang X, Wu X, Wang J, Chen W, Koelker-Wolfe E, Seet CS, Montel-Hagen A, Crooks GM, Forman SJ, Brown CE. PMID: 35278370; PMCID: PMC9119152.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry. Front Immunol. 2022; 13:833636. Yiu G, Rasmussen TK, Tsai BL, Diep VK, Haddon DJ, Tsoi J, Miller GD, Comin-Anduix B, Deleuran B, Crooks GM, Utz PJ. PMID: 35185925; PMCID: PMC8851522.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep Med. 2021 11 16; 2(11):100449. Li YR, Zhou Y, Kim YJ, Zhu Y, Ma F, Yu J, Wang YC, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, Huang J, Cheng D, Montel-Hagen A, Seet CS, Crooks GM, Larson SM, Sasine JP, Wang X, Pellegrini M, Ribas A, Kohn DB, Witte O, Wang P, Yang L. PMID: 34841295; PMCID: PMC8607011.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro. Front Immunol. 2021; 12:716661. Sun V, Sharpley M, Kaczor-Urbanowicz KE, Chang P, Montel-Hagen A, Lopez S, Zampieri A, Zhu Y, de Barros SC, Parekh C, Casero D, Banerjee U, Crooks GM. PMID: 34394122; PMCID: PMC8355594.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Correction to: Gene Editing Rescues in Vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System. J Clin Immunol. 2021 Jul; 41(5):863. Gardner CL, Pavel-Dinu M, Dobbs K, Bosticardo M, Reardon PK, Lack J, DeRavin SS, Le K, Bello E, Pala F, Delmonte OM, Malech H, Montel-Hagen A, Crooks G, Acuto O, Porteus MH, Notarangelo LD. PMID: 33821398.
      View in: PubMed   Mentions: 1     Fields:    
    10. Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency. N Engl J Med. 2021 05 27; 384(21):2002-2013. Kohn DB, Booth C, Shaw KL, Xu-Bayford J, Garabedian E, Trevisan V, Carbonaro-Sarracino DA, Soni K, Terrazas D, Snell K, Ikeda A, Leon-Rico D, Moore TB, Buckland KF, Shah AJ, Gilmour KC, De Oliveira S, Rivat C, Crooks GM, Izotova N, Tse J, Adams S, Shupien S, Ricketts H, Davila A, Uzowuru C, Icreverzi A, Barman P, Campo Fernandez B, Hollis RP, Coronel M, Yu A, Chun KM, Casas CE, Zhang R, Arduini S, Lynn F, Kudari M, Spezzi A, Zahn M, Heimke R, Labik I, Parrott R, Buckley RH, Reeves L, Cornetta K, Sokolic R, Hershfield M, Schmidt M, Candotti F, Malech HL, Thrasher AJ, Gaspar HB. PMID: 33974366; PMCID: PMC8240285.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCellsCTClinical Trials
    11. Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System. J Clin Immunol. 2021 07; 41(5):852-862. Gardner CL, Pavel-Dinu M, Dobbs K, Bosticardo M, Reardon PK, Lack J, DeRavin SS, Le K, Bello E, Pala F, Delmonte OM, Malech H, Montel-Hagan A, Crooks G, Acuto O, Porteus MH, Notarangelo LD. PMID: 33650026; PMCID: PMC8254788.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Adv Sci (Weinh). 2021 Feb; 8(4):2002500. Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K. PMID: 33643791; PMCID: PMC7887579.
      View in: PubMed   Mentions: 3     Fields:    
    13. In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells. Cell Rep. 2020 10 27; 33(4):108320. Montel-Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, Li S, Lopez S, Zhu Y, Chick B, He C, de Barros SC, Seet CS, Crooks GM. PMID: 33113379; PMCID: PMC7727762.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Pleiotropic Roles of VEGF in the Microenvironment of the Developing Thymus. J Immunol. 2020 11 01; 205(9):2423-2436. de Barros SC, Suterwala BT, He C, Ge S, Chick B, Blumberg GK, Kim K, Klein S, Zhu Y, Wang X, Casero D, Crooks GM. PMID: 32989093; PMCID: PMC7679052.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia. Blood Adv. 2020 06 23; 4(12):2611-2616. Bosticardo M, Pala F, Calzoni E, Delmonte OM, Dobbs K, Gardner CL, Sacchetti N, Kawai T, Garabedian EK, Draper D, Bergerson JRE, DeRavin SS, Freeman AF, Güngör T, Hartog N, Holland SM, Kohn DB, Malech HL, Markert ML, Weinacht KG, Villa A, Seet CS, Montel-Hagen A, Crooks GM, Notarangelo LD. PMID: 32556283; PMCID: PMC7322962.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    16. MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment. Nature. 2019 12; 576(7786):281-286. Calvanese V, Nguyen AT, Bolan TJ, Vavilina A, Su T, Lee LK, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA. PMID: 31776511; PMCID: PMC7278275.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    17. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 10 03; 25(4):542-557.e9. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. PMID: 31495780; PMCID: PMC7018522.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    18. Stimulation of Hair Growth by Small Molecules that Activate Autophagy. Cell Rep. 2019 06 18; 27(12):3413-3421.e3. Chai M, Jiang M, Vergnes L, Fu X, de Barros SC, Doan NB, Huang W, Chu J, Jiao J, Herschman H, Crooks GM, Reue K, Huang J. PMID: 31216464.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    19. Introduction. Exp Hematol. 2019 03; 71:1-2. Crooks GM, Eaves C. PMID: 30769021.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    20. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019 03 07; 24(3):376-389.e8. Montel-Hagen A, Seet CS, Li S, Chick B, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM. PMID: 30661959; PMCID: PMC6687310.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    21. From pluripotent stem cells to T cells. Exp Hematol. 2019 03; 71:24-31. Montel-Hagen A, Crooks GM. PMID: 30590093.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System. Clin Cancer Res. 2019 02 01; 25(3):1000-1011. Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, Goodwin JL, Bolon B, Seet CS, Montel-Hagen A, Crooks GM, Hollis RP, Campo-Fernandez B, Bischof D, Cornetta K, Gschweng EH, Adelson C, Nguyen A, Yang L, Witte ON, Baltimore D, Comin-Anduix B, Kohn DB, Wang X, Cabrera P, Kaplan-Lefko PJ, Berent-Maoz B, Ribas A. PMID: 30409823; PMCID: PMC6359988.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    23. Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells. Stem Cells. 2018 11; 36(11):1663-1675. Bapat A, Keita N, Martelly W, Kang P, Seet C, Jacobsen JR, Stoilov P, Hu C, Crooks GM, Sharma S. PMID: 30004607; PMCID: PMC6283046.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    24. Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells. Stem Cell Reports. 2018 02 13; 10(2):436-446. Chin CJ, Li S, Corselli M, Casero D, Zhu Y, He CB, Hardy R, Péault B, Crooks GM. PMID: 29307583; PMCID: PMC5830911.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    25. Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids. Nat Methods. 2017 May; 14(5):521-530. Seet CS, He C, Bethune MT, Li S, Chick B, Gschweng EH, Zhu Y, Kim K, Kohn DB, Baltimore D, Crooks GM, Montel-Hagen A. PMID: 28369043; PMCID: PMC5426913.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    26. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016 06; 18(6):595-606. Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. PMID: 27183470; PMCID: PMC4981340.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    27. Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. Stem Cells. 2016 05; 34(5):1239-50. Chin CJ, Cooper AR, Lill GR, Evseenko D, Zhu Y, He CB, Casero D, Pellegrini M, Kohn DB, Crooks GM. PMID: 26934332; PMCID: PMC5052131.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    28. BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer. 2015 Dec 22; 14:214. Rodríguez-Malavé NI, Fernando TR, Patel PC, Contreras JR, Palanichamy JK, Tran TM, Anguiano J, Davoren MJ, Alberti MO, Pioli KT, Sandoval S, Crooks GM, Rao DS. PMID: 26694754; PMCID: PMC4688921.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nat Immunol. 2015 Dec; 16(12):1282-91. Casero D, Sandoval S, Seet CS, Scholes J, Zhu Y, Ha VL, Luong A, Parekh C, Crooks GM. PMID: 26502406; PMCID: PMC4653072.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    30. Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. Am J Hematol. 2015 Nov; 90(11):1021-6. Abdel-Azim H, Mahadeo KM, Zhao Q, Khazal S, Kohn DB, Crooks GM, Shah AJ, Kapoor N. PMID: 26242764.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS One. 2015; 10(5):e0125414. Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K. PMID: 25933067; PMCID: PMC4416735.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. GPI-80 defines self-renewal ability in hematopoietic stem cells during human development. Cell Stem Cell. 2015 Jan 08; 16(1):80-7. Prashad SL, Calvanese V, Yao CY, Kaiser J, Wang Y, Sasidharan R, Crooks G, Magnusson M, Mikkola HK. PMID: 25465114; PMCID: PMC4520393.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    33. A reduced-toxicity regimen is associated with durable engraftment and clinical cure of nonmalignant genetic diseases among children undergoing blood and marrow transplantation with an HLA-matched related donor. Biol Blood Marrow Transplant. 2015 Mar; 21(3):440-4. Mahadeo KM, Weinberg KI, Abdel-Azim H, Miklos DB, Killen R, Kohn D, Crooks GM, Shah AJ, Kharbanda S, Agarwal R, Kapoor N. PMID: 25459642.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    34. Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem Cells. 2014 Sep; 32(9):2386-96. Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang OO, Crooks GM. PMID: 24801626; PMCID: PMC4138233.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    35. Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem Cells. 2014 Jun; 32(6):1503-14. Kim WS, Zhu Y, Deng Q, Chin CJ, He CB, Grieco AJ, Dravid GG, Parekh C, Hollis RP, Lane TF, Bouhassira EE, Kohn DB, Crooks GM. PMID: 24677652; PMCID: PMC4037366.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    36. Human lymphoid development in the absence of common γ-chain receptor signaling. J Immunol. 2014 Jun 01; 192(11):5050-8. Kohn LA, Seet CS, Scholes J, Codrea F, Chan R, Zaidi-Merchant S, Zhu Y, De Oliveira S, Kapoor N, Shah A, Abdel-Azim H, Kohn DB, Crooks GM. PMID: 24771849; PMCID: PMC4052377.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    37. Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell Stem Cell. 2014 Apr 03; 14(4):473-85. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. PMID: 24702996; PMCID: PMC4009343.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    38. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. PMID: 24371811; PMCID: PMC3871393.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    39. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One. 2013; 8(5):e63718. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. PMID: 23696850; PMCID: PMC3655943.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    40. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013 Apr 11; 121(15):2891-901. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, P?ault B. PMID: 23412095; PMCID: PMC3707421.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    41. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 07; 121(10):1814-8. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, M?schen M, Papayannopoulou T, Heisterkamp N, B?nig H, Kim YM. PMID: 23319569; PMCID: PMC3591800.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    42. Critical differences in hematopoiesis and lymphoid development between humans and mice. J Clin Immunol. 2013 May; 33(4):711-5. Parekh C, Crooks GM. PMID: 23274800; PMCID: PMC3633618.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    43. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PMID: 23056209; PMCID: PMC3467279.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood. 2012 Nov 01; 120(18):3635-46. Candotti F, Shaw KL, Muul L, Carbonaro D, Sokolic R, Choi C, Schurman SH, Garabedian E, Kesserwan C, Jagadeesh GJ, Fu PY, Gschweng E, Cooper A, Tisdale JF, Weinberg KI, Crooks GM, Kapoor N, Shah A, Abdel-Azim H, Yu XJ, Smogorzewska M, Wayne AS, Rosenblatt HM, Davis CM, Hanson C, Rishi RG, Wang X, Gjertson D, Yang OO, Balamurugan A, Bauer G, Ireland JA, Engel BC, Podsakoff GM, Hershfield MS, Blaese RM, Parkman R, Kohn DB. PMID: 22968453; PMCID: PMC3488882.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansCellsCTClinical Trials
    45. Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nat Immunol. 2012 Oct; 13(10):963-71. Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM. PMID: 22941246; PMCID: PMC3448017.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    46. Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors. Stem Cells. 2012 Apr; 30(4):697-708. Parekh C, Sahaghian A, Kim W, Scholes J, Ge S, Zhu Y, Asgharzadeh S, Hollis R, Kohn D, Ji L, Malvar J, Wang X, Crooks G. PMID: 22290824; PMCID: PMC3973153.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    47. Rapid thymic reconstitution following bone marrow transplantation in neonatal mice is VEGF-dependent. Biol Blood Marrow Transplant. 2012 May; 18(5):683-9. Cuddihy AR, Suterwala BT, Ge S, Kohn LA, Jang J, Andrade J, Wang X, Crooks GM. PMID: 22281302; PMCID: PMC3334422.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    48. Combined preconditioning and in�vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow. Exp Hematol. 2012 Jan; 40(1):3-13.e3. Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N. PMID: 22001673; PMCID: PMC4305396.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    49. Isolation of CD133+ liver stem cells for clonal expansion. J Vis Exp. 2011 Oct 10; (56). Rountree CB, Ding W, Dang H, Vankirk C, Crooks GM. PMID: 22006186; PMCID: PMC3227180.
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    50. Anti-CD52 antibody-mediated immune ablation with autologous immune recovery for the treatment of refractory juvenile polymyositis. J Clin Immunol. 2011 Aug; 31(4):615-22. Reiff A, Shaham B, Weinberg KI, Crooks GM, Parkman R. PMID: 21541793.
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    51. Lineage assays: which pathway to take? Blood. 2011 Mar 03; 117(9):2560. Crooks GM. PMID: 21372158.
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    52. The challenges and promises of blood engineered from human pluripotent stem cells. Adv Drug Deliv Rev. 2011 Apr 30; 63(4-5):331-41. Dravid GG, Crooks GM. PMID: 21232565.
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    53. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr; 19(4):768-81. Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. PMID: 21179006; PMCID: PMC3070091.
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    54. Effects of sublethal irradiation on patterns of engraftment after murine bone marrow transplantation. Biol Blood Marrow Transplant. 2011 May; 17(5):608-19. Andrade J, Ge S, Symbatyan G, Rosol MS, Olch AJ, Crooks GM. PMID: 21176787; PMCID: PMC3086732.
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    55. In vivo deficiency of both C/EBP� and C/EBPe results in highly defective myeloid differentiation and lack of cytokine response. PLoS One. 2010 Nov 03; 5(11):e15419. Akagi T, Thoennissen NH, George A, Crooks G, Song JH, Okamoto R, Nowak D, Gombart AF, Koeffler HP. PMID: 21072215; PMCID: PMC2972224.
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    56. Uncertainty plagues US stem cell research. Pediatr Res. 2010 Nov; 68(5):373. Crooks GM. PMID: 20940613.
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    57. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. PMID: 20643952; PMCID: PMC2922221.
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    58. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010 Aug; 28(8):839-47. Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, Crooks GM, Kohn DB, Gregory PD, Holmes MC, Cannon PM. PMID: 20601939; PMCID: PMC3080757.
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    59. Regulated expansion of human pancreatic beta-cells. Mol Ther. 2010 Jul; 18(7):1389-96. Pais E, Park J, Alexy T, Nikolian V, Ge S, Shaw K, Senadheera S, Hardee CL, Skelton D, Hollis R, Crooks GM, Kohn DB. PMID: 20389286; PMCID: PMC2911252.
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    60. Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. Hum Gene Ther. 2009 Dec; 20(12):1607-26. Sumiyoshi T, Holt NG, Hollis RP, Ge S, Cannon PM, Crooks GM, Kohn DB. PMID: 19689196; PMCID: PMC4094131.
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    61. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. PMID: 19021502.
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    62. Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2009 Jan; 52(1):139-42. Shah AJ, Kapoor N, Cooper RM, Crooks GM, Lenarsky C, Abdel-Azim H, Wu SQ, Wilson K, Weinberg KI, Parkman R, Kohn DB. PMID: 18819128; PMCID: PMC2592085.
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    63. Fluorescent immunohistochemistry and in situ hybridization analysis of pancreas. Methods Mol Biol. 2009; 560:191-201. Wang X, Ge S, Crooks GM. PMID: 19504251.
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    64. VEGF-mediated cross-talk within the neonatal murine thymus. Blood. 2009 Mar 19; 113(12):2723-31. Cuddihy AR, Ge S, Zhu J, Jang J, Chidgey A, Thurston G, Boyd R, Crooks GM. PMID: 19088378; PMCID: PMC2661859.
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    65. Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency. Pediatr Transplant. 2009 Mar; 13(2):244-50. Gruber TA, Shah AJ, Hernandez M, Crooks GM, Abdel-Azim H, Gupta S, McKnight S, White D, Kapoor N, Kohn DB. PMID: 18822103.
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    66. Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies. J Pediatr Hematol Oncol. 2008 Jun; 30(6):411-8. Shah AJ, Epport K, Azen C, Killen R, Wilson K, De Clerck D, Crooks G, Kapoor N, Kohn DB, Parkman R, Weinberg KI. PMID: 18525456.
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    67. Inferring relative numbers of human leucocyte genome replications. Br J Haematol. 2008 Jun; 141(6):862-71. Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shibata D. PMID: 18410448.
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    68. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008 Apr; 47(4):1288-97. Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. PMID: 18167064; PMCID: PMC2408692.
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    69. Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl. Blood. 2008 Apr 15; 111(8):4064-74. Abdel-Azim H, Zhu Y, Hollis R, Wang X, Ge S, Hao QL, Smbatyan G, Kohn DB, Rosol M, Crooks GM. PMID: 18174381; PMCID: PMC2288719.
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    70. Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Blood. 2008 Feb 01; 111(3):1318-26. Hao QL, George AA, Zhu J, Barsky L, Zielinska E, Wang X, Price M, Ge S, Crooks GM. PMID: 17959857; PMCID: PMC2214748.
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    71. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. PMID: 17668871; PMCID: PMC3494299.
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    72. A CD133-expressing murine liver oval cell population with bilineage potential. Stem Cells. 2007 Oct; 25(10):2419-29. Rountree CB, Barsky L, Ge S, Zhu J, Senadheera S, Crooks GM. PMID: 17585168.
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    73. Immune-cell lineage commitment: translation from mice to humans. Immunity. 2007 Jun; 26(6):674-7. Payne KJ, Crooks GM. PMID: 17582340.
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    74. Bone marrow fails to differentiate into liver epithelium during murine development and regeneration. Hepatology. 2007 May; 45(5):1250-60. Rountree CB, Wang X, Ge S, Barsky L, Zhu J, Gonzales I, Crooks GM. PMID: 17464997.
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    75. The effects of Campath 1H upon graft-versus-host disease, infection, relapse, and immune reconstitution in recipients of pediatric unrelated transplants. Biol Blood Marrow Transplant. 2007 May; 13(5):584-93. Shah AJ, Kapoor N, Crooks GM, Weinberg KI, Azim HA, Killen R, Kuo L, Rushing T, Kohn DB, Parkman R. PMID: 17448918.
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    76. The unpredictable stem cell. Nat Immunol. 2006 Nov; 7(11):1129-30. Crooks GM, Weinberg K. PMID: 17053793.
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    77. Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. Leuk Res. 2007 May; 31(5):643-51. Garon EB, Marcu L, Luong Q, Tcherniantchouk O, Crooks GM, Koeffler HP. PMID: 17027955; PMCID: PMC8761484.
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    78. Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon. Exp Hematol. 2006 Oct; 34(10):1333-43. Hollis RP, Nightingale SJ, Wang X, Pepper KA, Yu XJ, Barsky L, Crooks GM, Kohn DB. PMID: 16982326.
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    79. Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood. 2007 Jan 15; 109(2):503-6. Engel BC, Podsakoff GM, Ireland JL, Smogorzewska EM, Carbonaro DA, Wilson K, Shah A, Kapoor N, Sweeney M, Borchert M, Crooks GM, Weinberg KI, Parkman R, Rosenblatt HM, Wu SQ, Hershfield MS, Candotti F, Kohn DB. PMID: 16973956; PMCID: PMC1785101.
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    80. Fluorescent immunohistochemistry and in situ hybridization analysis of mouse pancreas using low-power antigen-retrieval technique. J Histochem Cytochem. 2006 Jul; 54(7):843-7. Ge S, Crooks GM, McNamara G, Wang X. PMID: 16549508.
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    81. Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells. 2006 Feb; 24(2):307-14. Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A, Crooks GM. PMID: 16510429.
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    82. Immune reconstitution: from stem cells to lymphocytes. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):42-6. Crooks GM, Weinberg K, Mackall C. PMID: 16399583.
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    83. Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B. Pediatrics. 2005 Oct; 116(4):1022-5. Shah AJ, Kapoor N, Crooks GM, Parkman R, Weinberg KI, Wilson K, Kohn DB. PMID: 16199719.
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    84. SCL expression at critical points in human hematopoietic lineage commitment. Stem Cells. 2005 Jun-Jul; 23(6):852-60. Zhang Y, Payne KJ, Zhu Y, Price MA, Parrish YK, Zielinska E, Barsky LW, Crooks GM. PMID: 15917481.
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    85. The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res. 2005 Apr 15; 65(8):3200-8. Jodele S, Chantrain CF, Blavier L, Lutzko C, Crooks GM, Shimada H, Coussens LM, Declerck YA. PMID: 15833851.
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    86. Distinct homeostatic requirements of CD4+ and CD4- subsets of Valpha24-invariant natural killer T cells in humans. Blood. 2004 Dec 15; 104(13):4150-6. Baev DV, Peng XH, Song L, Barnhart JR, Crooks GM, Weinberg KI, Metelitsa LS. PMID: 15328159.
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    87. Busulfan and cyclophosphamide as a conditioning regimen for pediatric acute lymphoblastic leukemia patients undergoing bone marrow transplantation. J Pediatr Hematol Oncol. 2004 Feb; 26(2):91-7. Shah AJ, Lenarsky C, Kapoor N, Crooks GM, Kohn DB, Parkman R, Epport K, Wilson K, Weinberg K. PMID: 14767194.
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    88. Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood. 2003 Nov 15; 102(10):3478-82. Wang X, Rosol M, Ge S, Peterson D, McNamara G, Pollack H, Kohn DB, Nelson MD, Crooks GM. PMID: 12946998.
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    89. Ikaros isoform x is selectively expressed in myeloid differentiation. J Immunol. 2003 Mar 15; 170(6):3091-8. Payne KJ, Huang G, Sahakian E, Zhu JY, Barteneva NS, Barsky LW, Payne MA, Crooks GM. PMID: 12626565.
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    90. Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood. 2003 May 15; 101(10):4201-8. Wang X, Ge S, McNamara G, Hao QL, Crooks GM, Nolta JA. PMID: 12560238; PMCID: PMC3781008.
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    91. Expression from second-generation feline immunodeficiency virus vectors is impaired in human hematopoietic cells. Mol Ther. 2002 Nov; 6(5):645-52. Price MA, Case SS, Carbonaro DA, Yu XJ, Petersen D, Sabo KM, Curran MA, Engel BC, Margarian H, Abkowitz JL, Nolan GP, Kohn DB, Crooks GM. PMID: 12409263.
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    92. Human hematopoietic lineage commitment. Immunol Rev. 2002 Sep; 187:48-64. Payne KJ, Crooks GM. PMID: 12366682.
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    93. Second hematopoietic stem cell transplantation in pediatric patients: overall survival and long-term follow-up. Biol Blood Marrow Transplant. 2002; 8(4):221-8. Shah AJ, Kapoor N, Weinberg KI, Crooks GM, Kohn DB, Lenarsky C, Kaufman F, Epport K, Wilson K, Parkman R. PMID: 12014811.
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