Gay M Crooks

Title(s)Professor, Pathology and Laboratory Medicine
SchoolMedicine
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    Title(s)Professor, Orthopaedic Surgery

    Title(s)Professor, Pediatrics


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    Dr. Gay M. Crooks holds the Rebecca Smith Chair in Molecular and Cellular Pathology.

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    Tumor Cell Biology Training Program
    NIH/NCI T32CA009056Aug 1, 2023 - Jul 31, 2028
    Role: Co-Principal Investigator
    Description: This training program’s goal is to span the disciplines of pathology, oncology, molecular biology, engineering, chemistry, bioinformatics and biomathematics related to modern medicine and biomedical research, in order to train the next generation of transdisciplinary scientists.
    The role of BCL11B in T lineage fate during human thymopoiesis and pluripotent stem cell differentiation
    NIH 1 R01 AI176249-01Jul 1, 2023 - Jun 30, 2028
    Role: Principal Investigator
    Description: The studies proposed are designed to further our understanding of how BCL11B induces T cell specification and commitment, and to apply these insights to the setting of T cell differentiation from human pluripotent stem cells (PSCs)
    Engineering pluripotent stem cells for universally available, off-the-shelf T cell therapies
    California Institute for Regenerative Medicine (CIRM) DISC0-14422Jul 1, 2023 - Jun 30, 2026
    Role: Principal Investigator
    Description: The overall objective of this proposal is to uncover the critical elements required to generate a universal source of off-the-shelf, mature, conventional CART cells from induced Pluripotent Stem Cells (iPSCs). Our studies will focus on the need to achieve normal differentiation of mature CART cells in the absence of TCR expression
    The Role of Lymphatic Endothelium in the Developing Thymus
    NIH/NIAID 1 R01 AI173496-01A1Jun 16, 2023 - May 31, 2028
    Role: Principal Investigator
    Description: The studies proposed will use the unique window of the murine neonatal period to define the factors that control the growth and regression of the lymphatic endothelial cells (LECs) in the thymus, as well as the role of LECs in the dramatic concurrent changes seen in the other thymic compartments.
    Targeting alternative splicing for TCR discovery in small cell carcinomas
    NIH U01CA233074Sep 21, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    “Inducing tolerance after VCA through Adoptive Therapy of Thymic Regulatory T cells”
    The Connie Frank and Evan Thompson Program for Collaborative Restorative Transplantation Research Jul 1, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Description: These studies will use a combination of murine and human ATO models to identify the optimal combination of factors for Treg production.
    Discovery and manipulation of mesenchymal signals for thymic rejuvenation
    NIH R01AG049753Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2221116120. Pan Y, Phillips JW, Zhang BD, Noguchi M, Kutschera E, McLaughlin J, Nesterenko PA, Mao Z, Bangayan NJ, Wang R, Tran W, Yang HT, Wang Y, Xu Y, Obusan MB, Cheng D, Lee AH, Kadash-Edmondson KE, Champhekar A, Puig-Saus C, Ribas A, Prins RM, Seet CS, Crooks GM, Witte ON, Xing Y. PMID: 37192158; PMCID: PMC10214192.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Layered immune system development in mice and humans. Immunol Rev. 2023 05; 315(1):5-10. Dorshkind K, Crooks G. PMID: 36960956.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing. Cell. 2023 03 30; 186(7):1398-1416.e23. McAuley GE, Yiu G, Chang PC, Newby GA, Campo-Fernandez B, Fitz-Gibbon ST, Wu X, Kang SL, Garibay A, Butler J, Christian V, Wong RL, Everette KA, Azzun A, Gelfer H, Seet CS, Narendran A, Murguia-Favela L, Romero Z, Wright N, Liu DR, Crooks GM, Kohn DB. PMID: 36944331.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. Strength of CAR signaling determines T cell versus ILC differentiation from pluripotent stem cells. Cell Rep. 2023 03 28; 42(3):112241. Li S, Wang CS, Montel-Hagen A, Chen HC, Lopez S, Zhou O, Dai K, Tsai S, Satyadi W, Botero C, Wong C, Casero D, Crooks GM, Seet CS. PMID: 36906850; PMCID: PMC10315155.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity. J Clin Invest. 2022 08 15; 132(16). Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. PMID: 35653193; PMCID: PMC9374381.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Physical and in silico immunopeptidomic profiling of a cancer antigen prostatic acid phosphatase reveals targets enabling TCR isolation. Proc Natl Acad Sci U S A. 2022 08 02; 119(31):e2203410119. Mao Z, Nesterenko PA, McLaughlin J, Deng W, Burton Sojo G, Cheng D, Noguchi M, Chour W, DeLucia DC, Finton KA, Qin Y, Obusan MB, Tran W, Wang L, Bangayan NJ, Ta L, Chen CC, Seet CS, Crooks GM, Phillips JW, Heath JR, Strong RK, Lee JK, Wohlschlegel JA, Witte ON. PMID: 35878026; PMCID: PMC9351518.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells. Cell Stem Cell. 2022 Apr 07; 29(4):651-653. Wang Z, McWilliams-Koeppen HP, Reza H, Ostberg JR, Chen W, Wang X, Huynh C, Vyas V, Chang WC, Starr R, Wagner JR, Aguilar B, Yang X, Wu X, Wang J, Chen W, Koelker-Wolfe E, Seet CS, Montel-Hagen A, Crooks GM, Forman SJ, Brown CE. PMID: 35395190.
      View in: PubMed   Mentions: 2     Fields:    
    8. Generation of Artificial Thymic Organoids from Human and Murine Hematopoietic Stem and Progenitor Cells. Curr Protoc. 2022 Apr; 2(4):e403. Montel-Hagen A, Tsai S, Seet CS, Crooks GM. PMID: 35384408.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells. Cell Stem Cell. 2022 04 07; 29(4):515-527.e8. Wang Z, McWilliams-Koeppen HP, Reza H, Ostberg JR, Chen W, Wang X, Huynh C, Vyas V, Chang WC, Starr R, Wagner JR, Aguilar B, Yang X, Wu X, Wang J, Chen W, Koelker-Wolfe E, Seet CS, Montel-Hagen A, Crooks GM, Forman SJ, Brown CE. PMID: 35278370; PMCID: PMC9119152.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    10. High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry. Front Immunol. 2022; 13:833636. Yiu G, Rasmussen TK, Tsai BL, Diep VK, Haddon DJ, Tsoi J, Miller GD, Comin-Anduix B, Deleuran B, Crooks GM, Utz PJ. PMID: 35185925; PMCID: PMC8851522.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep Med. 2021 11 16; 2(11):100449. Li YR, Zhou Y, Kim YJ, Zhu Y, Ma F, Yu J, Wang YC, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, Huang J, Cheng D, Montel-Hagen A, Seet CS, Crooks GM, Larson SM, Sasine JP, Wang X, Pellegrini M, Ribas A, Kohn DB, Witte O, Wang P, Yang L. PMID: 34841295; PMCID: PMC8607011.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    12. The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro. Front Immunol. 2021; 12:716661. Sun V, Sharpley M, Kaczor-Urbanowicz KE, Chang P, Montel-Hagen A, Lopez S, Zampieri A, Zhu Y, de Barros SC, Parekh C, Casero D, Banerjee U, Crooks GM. PMID: 34394122; PMCID: PMC8355594.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Correction to: Gene Editing Rescues in Vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System. J Clin Immunol. 2021 Jul; 41(5):863. Gardner CL, Pavel-Dinu M, Dobbs K, Bosticardo M, Reardon PK, Lack J, DeRavin SS, Le K, Bello E, Pala F, Delmonte OM, Malech H, Montel-Hagen A, Crooks G, Acuto O, Porteus MH, Notarangelo LD. PMID: 33821398.
      View in: PubMed   Mentions:    Fields:    
    14. Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency. N Engl J Med. 2021 05 27; 384(21):2002-2013. Kohn DB, Booth C, Shaw KL, Xu-Bayford J, Garabedian E, Trevisan V, Carbonaro-Sarracino DA, Soni K, Terrazas D, Snell K, Ikeda A, Leon-Rico D, Moore TB, Buckland KF, Shah AJ, Gilmour KC, De Oliveira S, Rivat C, Crooks GM, Izotova N, Tse J, Adams S, Shupien S, Ricketts H, Davila A, Uzowuru C, Icreverzi A, Barman P, Campo Fernandez B, Hollis RP, Coronel M, Yu A, Chun KM, Casas CE, Zhang R, Arduini S, Lynn F, Kudari M, Spezzi A, Zahn M, Heimke R, Labik I, Parrott R, Buckley RH, Reeves L, Cornetta K, Sokolic R, Hershfield M, Schmidt M, Candotti F, Malech HL, Thrasher AJ, Gaspar HB. PMID: 33974366; PMCID: PMC8240285.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCellsCTClinical Trials
    15. Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System. J Clin Immunol. 2021 07; 41(5):852-862. Gardner CL, Pavel-Dinu M, Dobbs K, Bosticardo M, Reardon PK, Lack J, DeRavin SS, Le K, Bello E, Pala F, Delmonte OM, Malech H, Montel-Hagan A, Crooks G, Acuto O, Porteus MH, Notarangelo LD. PMID: 33650026; PMCID: PMC8254788.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    16. Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Adv Sci (Weinh). 2021 Feb; 8(4):2002500. Zbinden A, Layland SL, Urbanczyk M, Carvajal Berrio DA, Marzi J, Zauner M, Hammerschmidt A, Brauchle EM, Sudrow K, Fink S, Templin M, Liebscher S, Klein G, Deb A, Duffy GP, Crooks GM, Eble JA, Mikkola HKA, Nsair A, Seifert M, Schenke-Layland K. PMID: 33643791; PMCID: PMC7887579.
      View in: PubMed   Mentions: 8     Fields:    
    17. In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells. Cell Rep. 2020 10 27; 33(4):108320. Montel-Hagen A, Sun V, Casero D, Tsai S, Zampieri A, Jackson N, Li S, Lopez S, Zhu Y, Chick B, He C, de Barros SC, Seet CS, Crooks GM. PMID: 33113379; PMCID: PMC7727762.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Pleiotropic Roles of VEGF in the Microenvironment of the Developing Thymus. J Immunol. 2020 11 01; 205(9):2423-2436. de Barros SC, Suterwala BT, He C, Ge S, Chick B, Blumberg GK, Kim K, Klein S, Zhu Y, Wang X, Casero D, Crooks GM. PMID: 32989093; PMCID: PMC7679052.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    19. Artificial thymic organoids represent a reliable tool to study T-cell differentiation in patients with severe T-cell lymphopenia. Blood Adv. 2020 06 23; 4(12):2611-2616. Bosticardo M, Pala F, Calzoni E, Delmonte OM, Dobbs K, Gardner CL, Sacchetti N, Kawai T, Garabedian EK, Draper D, Bergerson JRE, DeRavin SS, Freeman AF, Güngör T, Hartog N, Holland SM, Kohn DB, Malech HL, Markert ML, Weinacht KG, Villa A, Seet CS, Montel-Hagen A, Crooks GM, Notarangelo LD. PMID: 32556283; PMCID: PMC7322962.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    20. MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment. Nature. 2019 12; 576(7786):281-286. Calvanese V, Nguyen AT, Bolan TJ, Vavilina A, Su T, Lee LK, Wang Y, Lay FD, Magnusson M, Crooks GM, Kurdistani SK, Mikkola HKA. PMID: 31776511; PMCID: PMC7278275.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    21. Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. Cell Stem Cell. 2019 10 03; 25(4):542-557.e9. Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L. PMID: 31495780; PMCID: PMC7018522.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    22. Stimulation of Hair Growth by Small Molecules that Activate Autophagy. Cell Rep. 2019 06 18; 27(12):3413-3421.e3. Chai M, Jiang M, Vergnes L, Fu X, de Barros SC, Doan NB, Huang W, Chu J, Jiao J, Herschman H, Crooks GM, Reue K, Huang J. PMID: 31216464.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    23. Introduction. Exp Hematol. 2019 03; 71:1-2. Crooks GM, Eaves C. PMID: 30769021.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    24. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell. 2019 03 07; 24(3):376-389.e8. Montel-Hagen A, Seet CS, Li S, Chick B, Zhu Y, Chang P, Tsai S, Sun V, Lopez S, Chen HC, He C, Chin CJ, Casero D, Crooks GM. PMID: 30661959; PMCID: PMC6687310.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    25. From pluripotent stem cells to T cells. Exp Hematol. 2019 03; 71:24-31. Montel-Hagen A, Crooks GM. PMID: 30590093.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System. Clin Cancer Res. 2019 02 01; 25(3):1000-1011. Puig-Saus C, Parisi G, Garcia-Diaz A, Krystofinski PE, Sandoval S, Zhang R, Champhekar AS, McCabe J, Cheung-Lau GC, Truong NA, Vega-Crespo A, Komenan MDS, Pang J, Macabali MH, Saco JD, Goodwin JL, Bolon B, Seet CS, Montel-Hagen A, Crooks GM, Hollis RP, Campo-Fernandez B, Bischof D, Cornetta K, Gschweng EH, Adelson C, Nguyen A, Yang L, Witte ON, Baltimore D, Comin-Anduix B, Kohn DB, Wang X, Cabrera P, Kaplan-Lefko PJ, Berent-Maoz B, Ribas A. PMID: 30409823; PMCID: PMC6359988.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    27. Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2-M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells. Stem Cells. 2018 11; 36(11):1663-1675. Bapat A, Keita N, Martelly W, Kang P, Seet C, Jacobsen JR, Stoilov P, Hu C, Crooks GM, Sharma S. PMID: 30004607; PMCID: PMC6283046.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    28. Transcriptionally and Functionally Distinct Mesenchymal Subpopulations Are Generated from Human Pluripotent Stem Cells. Stem Cell Reports. 2018 02 13; 10(2):436-446. Chin CJ, Li S, Corselli M, Casero D, Zhu Y, He CB, Hardy R, Péault B, Crooks GM. PMID: 29307583; PMCID: PMC5830911.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    29. Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids. Nat Methods. 2017 May; 14(5):521-530. Seet CS, He C, Bethune MT, Li S, Chick B, Gschweng EH, Zhu Y, Kim K, Kohn DB, Baltimore D, Crooks GM, Montel-Hagen A. PMID: 28369043; PMCID: PMC5426913.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    30. The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation. Leukemia. 2017 11; 31(11):2503-2514. Ha VL, Luong A, Li F, Casero D, Malvar J, Kim YM, Bhatia R, Crooks GM, Parekh C. PMID: 28232744; PMCID: PMC5599326.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    31. Medial HOXA genes demarcate haematopoietic stem cell fate during human development. Nat Cell Biol. 2016 06; 18(6):595-606. Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK. PMID: 27183470; PMCID: PMC4981340.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    32. Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. Stem Cells. 2016 05; 34(5):1239-50. Chin CJ, Cooper AR, Lill GR, Evseenko D, Zhu Y, He CB, Casero D, Pellegrini M, Kohn DB, Crooks GM. PMID: 26934332; PMCID: PMC5052131.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    33. BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer. 2015 Dec 22; 14:214. Rodríguez-Malavé NI, Fernando TR, Patel PC, Contreras JR, Palanichamy JK, Tran TM, Anguiano J, Davoren MJ, Alberti MO, Pioli KT, Sandoval S, Crooks GM, Rao DS. PMID: 26694754; PMCID: PMC4688921.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    34. Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. Nat Immunol. 2015 Dec; 16(12):1282-91. Casero D, Sandoval S, Seet CS, Scholes J, Zhu Y, Ha VL, Luong A, Parekh C, Crooks GM. PMID: 26502406; PMCID: PMC4653072.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    35. Unrelated donor hematopoietic stem cell transplantation for the treatment of non-malignant genetic diseases: An alemtuzumab based regimen is associated with cure of clinical disease; earlier clearance of alemtuzumab may be associated with graft rejection. Am J Hematol. 2015 Nov; 90(11):1021-6. Abdel-Azim H, Mahadeo KM, Zhao Q, Khazal S, Kohn DB, Crooks GM, Shah AJ, Kapoor N. PMID: 26242764.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    36. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS One. 2015; 10(5):e0125414. Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K. PMID: 25933067; PMCID: PMC4416735.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. Osteoarthritis Cartilage. 2015 Feb; 23(2):308-18. Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D. PMID: 25464168; PMCID: PMC4465392.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    38. GPI-80 defines self-renewal ability in hematopoietic stem cells during human development. Cell Stem Cell. 2015 Jan 08; 16(1):80-7. Prashad SL, Calvanese V, Yao CY, Kaiser J, Wang Y, Sasidharan R, Crooks G, Magnusson M, Mikkola HK. PMID: 25465114; PMCID: PMC4520393.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    39. A reduced-toxicity regimen is associated with durable engraftment and clinical cure of nonmalignant genetic diseases among children undergoing blood and marrow transplantation with an HLA-matched related donor. Biol Blood Marrow Transplant. 2015 Mar; 21(3):440-4. Mahadeo KM, Weinberg KI, Abdel-Azim H, Miklos DB, Killen R, Kohn D, Crooks GM, Shah AJ, Kharbanda S, Agarwal R, Kapoor N. PMID: 25459642.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    40. Engineering the human thymic microenvironment to support thymopoiesis in vivo. Stem Cells. 2014 Sep; 32(9):2386-96. Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang OO, Crooks GM. PMID: 24801626; PMCID: PMC4138233.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    41. Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Stem Cells. 2014 Jun; 32(6):1503-14. Kim WS, Zhu Y, Deng Q, Chin CJ, He CB, Grieco AJ, Dravid GG, Parekh C, Hollis RP, Lane TF, Bouhassira EE, Kohn DB, Crooks GM. PMID: 24677652; PMCID: PMC4037366.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    42. Human lymphoid development in the absence of common γ-chain receptor signaling. J Immunol. 2014 Jun 01; 192(11):5050-8. Kohn LA, Seet CS, Scholes J, Codrea F, Chan R, Zaidi-Merchant S, Zhu Y, De Oliveira S, Kapoor N, Shah A, Abdel-Azim H, Kohn DB, Crooks GM. PMID: 24771849; PMCID: PMC4052377.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    43. Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Cell Stem Cell. 2014 Apr 03; 14(4):473-85. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. PMID: 24702996; PMCID: PMC4009343.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    44. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. PMID: 24371811; PMCID: PMC3871393.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    45. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One. 2013; 8(5):e63718. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. PMID: 23696850; PMCID: PMC3655943.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    46. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013 Apr 11; 121(15):2891-901. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. PMID: 23412095; PMCID: PMC3707421.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    47. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 07; 121(10):1814-8. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. PMID: 23319569; PMCID: PMC3591800.
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    48. Critical differences in hematopoiesis and lymphoid development between humans and mice. J Clin Immunol. 2013 May; 33(4):711-5. Parekh C, Crooks GM. PMID: 23274800; PMCID: PMC3633618.
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    49. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PMID: 23056209; PMCID: PMC3467279.
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    50. Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood. 2012 Nov 01; 120(18):3635-46. Candotti F, Shaw KL, Muul L, Carbonaro D, Sokolic R, Choi C, Schurman SH, Garabedian E, Kesserwan C, Jagadeesh GJ, Fu PY, Gschweng E, Cooper A, Tisdale JF, Weinberg KI, Crooks GM, Kapoor N, Shah A, Abdel-Azim H, Yu XJ, Smogorzewska M, Wayne AS, Rosenblatt HM, Davis CM, Hanson C, Rishi RG, Wang X, Gjertson D, Yang OO, Balamurugan A, Bauer G, Ireland JA, Engel BC, Podsakoff GM, Hershfield MS, Blaese RM, Parkman R, Kohn DB. PMID: 22968453; PMCID: PMC3488882.
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    51. Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Nat Immunol. 2012 Oct; 13(10):963-71. Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM. PMID: 22941246; PMCID: PMC3448017.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    52. Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors. Stem Cells. 2012 Apr; 30(4):697-708. Parekh C, Sahaghian A, Kim W, Scholes J, Ge S, Zhu Y, Asgharzadeh S, Hollis R, Kohn D, Ji L, Malvar J, Wang X, Crooks G. PMID: 22290824; PMCID: PMC3973153.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    53. Rapid thymic reconstitution following bone marrow transplantation in neonatal mice is VEGF-dependent. Biol Blood Marrow Transplant. 2012 May; 18(5):683-9. Cuddihy AR, Suterwala BT, Ge S, Kohn LA, Jang J, Andrade J, Wang X, Crooks GM. PMID: 22281302; PMCID: PMC3334422.
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    54. Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow. Exp Hematol. 2012 Jan; 40(1):3-13.e3. Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N. PMID: 22001673; PMCID: PMC4305396.
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    55. Isolation of CD133+ liver stem cells for clonal expansion. J Vis Exp. 2011 Oct 10; (56). Rountree CB, Ding W, Dang H, Vankirk C, Crooks GM. PMID: 22006186; PMCID: PMC3227180.
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    56. Anti-CD52 antibody-mediated immune ablation with autologous immune recovery for the treatment of refractory juvenile polymyositis. J Clin Immunol. 2011 Aug; 31(4):615-22. Reiff A, Shaham B, Weinberg KI, Crooks GM, Parkman R. PMID: 21541793.
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    57. Lineage assays: which pathway to take? Blood. 2011 Mar 03; 117(9):2560. Crooks GM. PMID: 21372158.
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    58. The challenges and promises of blood engineered from human pluripotent stem cells. Adv Drug Deliv Rev. 2011 Apr 30; 63(4-5):331-41. Dravid GG, Crooks GM. PMID: 21232565.
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    59. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr; 19(4):768-81. Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. PMID: 21179006; PMCID: PMC3070091.
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    60. Effects of sublethal irradiation on patterns of engraftment after murine bone marrow transplantation. Biol Blood Marrow Transplant. 2011 May; 17(5):608-19. Andrade J, Ge S, Symbatyan G, Rosol MS, Olch AJ, Crooks GM. PMID: 21176787; PMCID: PMC3086732.
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    61. In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response. PLoS One. 2010 Nov 03; 5(11):e15419. Akagi T, Thoennissen NH, George A, Crooks G, Song JH, Okamoto R, Nowak D, Gombart AF, Koeffler HP. PMID: 21072215; PMCID: PMC2972224.
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    62. Uncertainty plagues US stem cell research. Pediatr Res. 2010 Nov; 68(5):373. Crooks GM. PMID: 20940613.
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    63. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. PMID: 20643952; PMCID: PMC2922221.
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    64. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010 Aug; 28(8):839-47. Holt N, Wang J, Kim K, Friedman G, Wang X, Taupin V, Crooks GM, Kohn DB, Gregory PD, Holmes MC, Cannon PM. PMID: 20601939; PMCID: PMC3080757.
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    65. Regulated expansion of human pancreatic beta-cells. Mol Ther. 2010 Jul; 18(7):1389-96. Pais E, Park J, Alexy T, Nikolian V, Ge S, Shaw K, Senadheera S, Hardee CL, Skelton D, Hollis R, Crooks GM, Kohn DB. PMID: 20389286; PMCID: PMC2911252.
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    66. Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system. Hum Gene Ther. 2009 Dec; 20(12):1607-26. Sumiyoshi T, Holt NG, Hollis RP, Ge S, Cannon PM, Crooks GM, Kohn DB. PMID: 19689196; PMCID: PMC4094131.
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    67. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. PMID: 19021502.
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    68. Lentiviral vectors with amplified beta cell-specific gene expression. Gene Ther. 2009 Aug; 16(8):998-1008. Shaw KL, Pais E, Ge S, Hardee C, Skelton D, Hollis RP, Crooks GM, Kohn DB. PMID: 19440227; PMCID: PMC2726899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    69. Fluorescent immunohistochemistry and in situ hybridization analysis of pancreas. Methods Mol Biol. 2009; 560:191-201. Wang X, Ge S, Crooks GM. PMID: 19504251.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    70. Pre- and post-natal treatment of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2009 Jan; 52(1):139-42. Shah AJ, Kapoor N, Cooper RM, Crooks GM, Lenarsky C, Abdel-Azim H, Wu SQ, Wilson K, Weinberg KI, Parkman R, Kohn DB. PMID: 18819128; PMCID: PMC2592085.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    71. VEGF-mediated cross-talk within the neonatal murine thymus. Blood. 2009 Mar 19; 113(12):2723-31. Cuddihy AR, Ge S, Zhu J, Jang J, Chidgey A, Thurston G, Boyd R, Crooks GM. PMID: 19088378; PMCID: PMC2661859.
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    72. Clinical and genetic heterogeneity in Omenn syndrome and severe combined immune deficiency. Pediatr Transplant. 2009 Mar; 13(2):244-50. Gruber TA, Shah AJ, Hernandez M, Crooks GM, Abdel-Azim H, Gupta S, McKnight S, White D, Kapoor N, Kohn DB. PMID: 18822103.
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    73. Progressive declines in neurocognitive function among survivors of hematopoietic stem cell transplantation for pediatric hematologic malignancies. J Pediatr Hematol Oncol. 2008 Jun; 30(6):411-8. Shah AJ, Epport K, Azen C, Killen R, Wilson K, De Clerck D, Crooks G, Kapoor N, Kohn DB, Parkman R, Weinberg KI. PMID: 18525456.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    74. Inferring relative numbers of human leucocyte genome replications. Br J Haematol. 2008 Jun; 141(6):862-71. Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shibata D. PMID: 18410448.
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    75. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008 Apr; 47(4):1288-97. Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. PMID: 18167064; PMCID: PMC2408692.
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    76. Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl. Blood. 2008 Apr 15; 111(8):4064-74. Abdel-Azim H, Zhu Y, Hollis R, Wang X, Ge S, Hao QL, Smbatyan G, Kohn DB, Rosol M, Crooks GM. PMID: 18174381; PMCID: PMC2288719.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    77. Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7- lympho-myeloid thymic progenitors. Blood. 2008 Feb 01; 111(3):1318-26. Hao QL, George AA, Zhu J, Barsky L, Zielinska E, Wang X, Price M, Ge S, Crooks GM. PMID: 17959857; PMCID: PMC2214748.
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    78. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. PMID: 17668871; PMCID: PMC3494299.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    79. A CD133-expressing murine liver oval cell population with bilineage potential. Stem Cells. 2007 Oct; 25(10):2419-29. Rountree CB, Barsky L, Ge S, Zhu J, Senadheera S, Crooks GM. PMID: 17585168.
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    80. Immune-cell lineage commitment: translation from mice to humans. Immunity. 2007 Jun; 26(6):674-7. Payne KJ, Crooks GM. PMID: 17582340.
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    81. Bone marrow fails to differentiate into liver epithelium during murine development and regeneration. Hepatology. 2007 May; 45(5):1250-60. Rountree CB, Wang X, Ge S, Barsky L, Zhu J, Gonzales I, Crooks GM. PMID: 17464997.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    82. The effects of Campath 1H upon graft-versus-host disease, infection, relapse, and immune reconstitution in recipients of pediatric unrelated transplants. Biol Blood Marrow Transplant. 2007 May; 13(5):584-93. Shah AJ, Kapoor N, Crooks GM, Weinberg KI, Azim HA, Killen R, Kuo L, Rushing T, Kohn DB, Parkman R. PMID: 17448918.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsCTClinical Trials
    83. The unpredictable stem cell. Nat Immunol. 2006 Nov; 7(11):1129-30. Crooks GM, Weinberg K. PMID: 17053793.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    84. Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. Leuk Res. 2007 May; 31(5):643-51. Garon EB, Marcu L, Luong Q, Tcherniantchouk O, Crooks GM, Koeffler HP. PMID: 17027955; PMCID: PMC8761484.
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    85. Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon. Exp Hematol. 2006 Oct; 34(10):1333-43. Hollis RP, Nightingale SJ, Wang X, Pepper KA, Yu XJ, Barsky L, Crooks GM, Kohn DB. PMID: 16982326.
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    86. Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report. Blood. 2007 Jan 15; 109(2):503-6. Engel BC, Podsakoff GM, Ireland JL, Smogorzewska EM, Carbonaro DA, Wilson K, Shah A, Kapoor N, Sweeney M, Borchert M, Crooks GM, Weinberg KI, Parkman R, Rosenblatt HM, Wu SQ, Hershfield MS, Candotti F, Kohn DB. PMID: 16973956; PMCID: PMC1785101.
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    87. Fluorescent immunohistochemistry and in situ hybridization analysis of mouse pancreas using low-power antigen-retrieval technique. J Histochem Cytochem. 2006 Jul; 54(7):843-7. Ge S, Crooks GM, McNamara G, Wang X. PMID: 16549508.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    88. Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells. 2006 Feb; 24(2):307-14. Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A, Crooks GM. PMID: 16510429.
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    89. Immune reconstitution: from stem cells to lymphocytes. Biol Blood Marrow Transplant. 2006 Jan; 12(1 Suppl 1):42-6. Crooks GM, Weinberg K, Mackall C. PMID: 16399583.
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    90. Recommendations for best practices in the treatment of Alzheimer's disease in managed care. Am J Geriatr Pharmacother. 2006; 4 Suppl A:S9-S24; quiz S25-S28. Fillit HM, Doody RS, Binaso K, Crooks GM, Ferris SH, Farlow MR, Leifer B, Mills C, Minkoff N, Orland B, Reichman WE, Salloway S. PMID: 17157793.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    91. Successful hematopoietic stem cell transplantation for Niemann-Pick disease type B. Pediatrics. 2005 Oct; 116(4):1022-5. Shah AJ, Kapoor N, Crooks GM, Parkman R, Weinberg KI, Wilson K, Kohn DB. PMID: 16199719.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    92. SCL expression at critical points in human hematopoietic lineage commitment. Stem Cells. 2005 Jun-Jul; 23(6):852-60. Zhang Y, Payne KJ, Zhu Y, Price MA, Parrish YK, Zielinska E, Barsky LW, Crooks GM. PMID: 15917481.
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    93. The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res. 2005 Apr 15; 65(8):3200-8. Jodele S, Chantrain CF, Blavier L, Lutzko C, Crooks GM, Shimada H, Coussens LM, Declerck YA. PMID: 15833851.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    94. Distinct homeostatic requirements of CD4+ and CD4- subsets of Valpha24-invariant natural killer T cells in humans. Blood. 2004 Dec 15; 104(13):4150-6. Baev DV, Peng XH, Song L, Barnhart JR, Crooks GM, Weinberg KI, Metelitsa LS. PMID: 15328159.
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    95. Busulfan and cyclophosphamide as a conditioning regimen for pediatric acute lymphoblastic leukemia patients undergoing bone marrow transplantation. J Pediatr Hematol Oncol. 2004 Feb; 26(2):91-7. Shah AJ, Lenarsky C, Kapoor N, Crooks GM, Kohn DB, Parkman R, Epport K, Wilson K, Weinberg K. PMID: 14767194.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    96. Dynamic tracking of human hematopoietic stem cell engraftment using in vivo bioluminescence imaging. Blood. 2003 Nov 15; 102(10):3478-82. Wang X, Rosol M, Ge S, Peterson D, McNamara G, Pollack H, Kohn DB, Nelson MD, Crooks GM. PMID: 12946998.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    97. Ikaros isoform x is selectively expressed in myeloid differentiation. J Immunol. 2003 Mar 15; 170(6):3091-8. Payne KJ, Huang G, Sahakian E, Zhu JY, Barteneva NS, Barsky LW, Payne MA, Crooks GM. PMID: 12626565.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    98. Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood. 2003 May 15; 101(10):4201-8. Wang X, Ge S, McNamara G, Hao QL, Crooks GM, Nolta JA. PMID: 12560238; PMCID: PMC3781008.
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    99. The AFT024 stromal cell line supports long-term ex vivo maintenance of engrafting multipotent human hematopoietic progenitors. Leukemia. 2002 Mar; 16(3):352-61. Nolta JA, Thiemann FT, Arakawa-Hoyt J, Dao MA, Barsky LW, Moore KA, Lemischka IR, Crooks GM. PMID: 11896538.
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    100. Second hematopoietic stem cell transplantation in pediatric patients: overall survival and long-term follow-up. Biol Blood Marrow Transplant. 2002; 8(4):221-8. Shah AJ, Kapoor N, Weinberg KI, Crooks GM, Kohn DB, Lenarsky C, Kaufman F, Epport K, Wilson K, Parkman R. PMID: 12014811.
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    101. Hematopoietic stem cell transplantation for severe combined immune deficiency. Curr Allergy Asthma Rep. 2001 Sep; 1(5):416-20. Weinberg KI, Kapoor N, Shah AJ, Crooks GM, Kohn DB, Parkman R. PMID: 11892067.
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    102. Cutting edge: predominant expression of a novel Ikaros isoform in normal human hemopoiesis. J Immunol. 2001 Aug 15; 167(4):1867-70. Payne KJ, Nicolas JH, Zhu JY, Barsky LW, Crooks GM. PMID: 11489963.
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    103. Detection of leukemic cells in the CD34(+)CD38(-) bone marrow progenitor population in children with acute lymphoblastic leukemia. Blood. 2001 Jun 15; 97(12):3925-30. George AA, Franklin J, Kerkof K, Shah AJ, Price M, Tsark E, Bockstoce D, Yao D, Hart N, Carcich S, Parkman R, Crooks GM, Weinberg K. PMID: 11389036.
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    104. Identification of a novel, human multilymphoid progenitor in cord blood. Blood. 2001 Jun 15; 97(12):3683-90. Hao QL, Zhu J, Price MA, Payne KJ, Barsky LW, Crooks GM. PMID: 11389003.
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    105. IL-3 increases production of B lymphoid progenitors from human CD34+CD38- cells. J Immunol. 2000 Sep 01; 165(5):2382-9. Crooks GM, Hao QL, Petersen D, Barsky LW, Bockstoce D. PMID: 10946261.
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    106. Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors. Mol Ther. 2000 Jul; 2(1):71-80. Haas DL, Case SS, Crooks GM, Kohn DB. PMID: 10899830.
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    107. T cell depleted haploidentical bone marrow transplantation for the treatment of children with severe combined immunodeficiency. Arch Immunol Ther Exp (Warsz). 2000; 48(2):111-8. Smogorzewska EM, Brooks J, Annett G, Kapoor N, Crooks GM, Kohn DB, Parkman R, Weinberg KI. PMID: 10807052.
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    108. Spontaneous apoptosis in lymphocytes from patients with Wiskott-Aldrich syndrome: correlation of accelerated cell death and attenuated bcl-2 expression. Blood. 1999 Dec 01; 94(11):3872-82. Rawlings SL, Crooks GM, Bockstoce D, Barsky LW, Parkman R, Weinberg KI. PMID: 10572103.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    109. The number and generative capacity of human B lymphocyte progenitors, measured in vitro and in vivo, is higher in umbilical cord blood than in adult or pediatric bone marrow. Bone Marrow Transplant. 1999 Dec; 24(11):1167-76. Arakawa-Hoyt J, Dao MA, Thiemann F, Hao QL, Ertl DC, Weinberg KI, Crooks GM, Nolta JA. PMID: 10642804.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    110. Constitutive HOXA5 expression inhibits erythropoiesis and increases myelopoiesis from human hematopoietic progenitors. Blood. 1999 Jul 15; 94(2):519-28. Crooks GM, Fuller J, Petersen D, Izadi P, Malik P, Pattengale PK, Kohn DB, Gasson JC. PMID: 10397719.
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    111. Designing solutions for securing patient privacy--meeting the demands of health care in the 21st century. J Am Pharm Assoc (Wash). 1999 May-Jun; 39(3):402-7. Bluml BM, Crooks GM. PMID: 10363469.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    112. Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2988-93. Case SS, Price MA, Jordan CT, Yu XJ, Wang L, Bauer G, Haas DL, Xu D, Stripecke R, Naldini L, Kohn DB, Crooks GM. PMID: 10077624; PMCID: PMC15882.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    113. In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells. Blood. 1998 Dec 15; 92(12):4509-20. Fluckiger AC, Sanz E, Garcia-Lloret M, Su T, Hao QL, Kato R, Quan S, de la Hera A, Crooks GM, Witte ON, Rawlings DJ. PMID: 9845515.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    114. The murine stromal cell line AFT024 acts specifically on human CD34+CD38- progenitors to maintain primitive function and immunophenotype in vitro. Exp Hematol. 1998 Jul; 26(7):612-9. Thiemann FT, Moore KA, Smogorzewska EM, Lemischka IR, Crooks GM. PMID: 9657136.
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    115. In vitro identification of single CD34+CD38- cells with both lymphoid and myeloid potential. Blood. 1998 Jun 01; 91(11):4145-51. Hao QL, Smogorzewska EM, Barsky LW, Crooks GM. PMID: 9596660.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    116. Engraftment and retroviral marking of CD34+ and CD34+CD38- human hematopoietic progenitors assessed in immune-deficient mice. Blood. 1998 Feb 15; 91(4):1243-55. Dao MA, Shah AJ, Crooks GM, Nolta JA. PMID: 9454754.
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    117. Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro. Exp Hematol. 1997 Jan; 25(1):66-72. Rawlings DJ, Quan S, Hao QL, Thiemann FT, Smogorzewska M, Witte ON, Crooks GM. PMID: 8989909.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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