Kenneth A Dorshkind

Title(s)Professor, Pathology and Laboratory Medicine
Address760 Westwood Plaza A3-251
Los Angeles CA 90024
Phone69535, 69301
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    Collapse Research 
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    Effects of Age-Related Changes in the Microenvironment on Patterns of Hematopoiesis
    NIH/NIA R01AG056480Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Effects of Aging on Lymphoid Biased Hematopoietic Stem Cells
    NIH/NIA R56AG050587Sep 15, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia
    NIH/NCI R21CA173028Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on T Lineage Aging
    NIH/NIA R01AG034875Mar 15, 2009 - Feb 28, 2014
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on B Lineage Sensescence
    NIH/NIA R01AG021450Aug 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    Immunopathology Training Grant
    NIH/NIAID T32AI052031Jun 1, 2003 - May 31, 2008
    Role: Principal Investigator
    NIH/NCRR S10RR014888Apr 1, 2000 - Mar 31, 2001
    Role: Principal Investigator
    NIH/NHLBI R01HL060658Jul 10, 1998 - Jun 30, 2003
    Role: Principal Investigator
    NIH/NIA R01AG013132Aug 15, 1997 - Dec 31, 1999
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA016042Dec 1, 1996 - Nov 30, 2019
    Role: Co-Principal Investigator
    NIH/NIAID K04AI000843Sep 1, 1987 - Aug 31, 1992
    Role: Principal Investigator
    NIH/NHLBI R01HL036591Jul 1, 1986 - Jun 30, 1995
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH/NIAID R37AI021256Jul 1, 1984 - Nov 30, 2018
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH/NIAID R01AI021256Jul 1, 1984 - May 31, 1996
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 Sep 15. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981.
      View in: PubMed   Mentions:    Fields:    
    2. Do haematopoietic stem cells age? Nat Rev Immunol. 2020 03; 20(3):196-202. Dorshkind K, Höfer T, Montecino-Rodriguez E, Pioli PD, Rodewald HR. PMID: 31740804.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow. Immunity. 2019 08 20; 51(2):351-366.e6. Pioli PD, Casero D, Montecino-Rodriguez E, Morrison SL, Dorshkind K. PMID: 31303400.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. B1 B cell progenitors. Science. 2019 04 19; 364(6437):248. Ghosn E, Dorshkind K, Herzenberg LA, Holodick N, Kantor A, Montecino-Rodriguez E, Rothstein TL, Silverman GJ, Yang Y, Yoder MC, Yoshimoto M. PMID: 31000655.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny. Stem Cell Reports. 2019 03 05; 12(3):584-596. Montecino-Rodriguez E, Kong Y, Casero D, Rouault A, Dorshkind K, Pioli PD. PMID: 30799276.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    6. Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development. J Immunol. 2018 03 15; 200(6):2046-2056. Montecino-Rodriguez E, Casero D, Fice M, Le J, Dorshkind K. PMID: 29436414.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    7. Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development. Immunity. 2016 09 20; 45(3):527-539. Montecino-Rodriguez E, Fice M, Casero D, Berent-Maoz B, Barber CL, Dorshkind K. PMID: 27566938.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    8. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS One. 2015; 10(5):e0125414. Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K. PMID: 25933067.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Murine B-1 B cell progenitors initiate B-acute lymphoblastic leukemia with features of high-risk disease. J Immunol. 2014 Jun 01; 192(11):5171-8. Montecino-Rodriguez E, Li K, Fice M, Dorshkind K. PMID: 24752443.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    10. Shared signaling systems in myeloid cell-mediated muscle regeneration. Development. 2014 Mar; 141(6):1184-96. Tidball JG, Dorshkind K, Wehling-Henricks M. PMID: 24595286.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    11. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013 Mar; 123(3):958-65. Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. PMID: 23454758.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    12. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14; 119(24):5715-21. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. PMID: 22555975.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    13. Genetic regulation of thymocyte progenitor aging. Semin Immunol. 2012 Oct; 24(5):303-8. Berent-Maoz B, Montecino-Rodriguez E, Dorshkind K. PMID: 22559986.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. B-1 B cell development in the fetus and adult. Immunity. 2012 Jan 27; 36(1):13-21. Montecino-Rodriguez E, Dorshkind K. PMID: 22284417.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    15. Developmental relationships between B-1 and B-2 progenitors. . 2011 Nov 15; 10(22):3810-1. Barber CL, Montecino-Rodriguez E, Dorshkind K. PMID: 22071629.
      View in: PubMed   Mentions:
    16. Formation of B-1 B cells from neonatal B-1 transitional cells exhibits NF-κB redundancy. J Immunol. 2011 Dec 01; 187(11):5712-9. Montecino-Rodriguez E, Dorshkind K. PMID: 22031760.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13700-4. Barber CL, Montecino-Rodriguez E, Dorshkind K. PMID: 21808010.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    18. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1468-73. Yoshimoto M, Montecino-Rodriguez E, Ferkowicz MJ, Porayette P, Shelley WC, Conway SJ, Dorshkind K, Yoder MC. PMID: 21209332.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    19. Not a split decision for human hematopoiesis. Nat Immunol. 2010 Jul; 11(7):569-70. Dorshkind K. PMID: 20562840.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 20562326.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    21. Age-associated declines in immune system development and function: causes, consequences, and reversal. Curr Opin Immunol. 2009 Aug; 21(4):404-7. Dorshkind K, Swain S. PMID: 19632102.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    22. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62. Dorshkind K, Montecino-Rodriguez E, Signer RA. PMID: 19104499.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    23. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 19056891.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    24. Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes Dev. 2007 Sep 15; 21(18):2249-52. Dorshkind K, Witte ON. PMID: 17875661.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    25. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. PMID: 17554060.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    26. The protean nature of cells in the B lymphocyte lineage. Immunity. 2007 Jun; 26(6):703-14. Hardy RR, Kincade PW, Dorshkind K. PMID: 17582343.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    27. Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential. Nat Rev Immunol. 2007 Mar; 7(3):213-9. Dorshkind K, Montecino-Rodriguez E. PMID: 17318232.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    28. Fate decisions regulating bone marrow and peripheral B lymphocyte development. Adv Immunol. 2007; 95:1-50. Monroe JG, Dorshkind K. PMID: 17869609.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    29. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol. 2007 May; 42(5):391-5. Signer RA, Montecino-Rodriguez E, Dorshkind K. PMID: 17184948.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. New perspectives in B-1 B cell development and function. Trends Immunol. 2006 Sep; 27(9):428-33. Montecino-Rodriguez E, Dorshkind K. PMID: 16861037.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    31. Evolving patterns of lymphopoiesis from embryogenesis through senescence. Immunity. 2006 Jun; 24(6):659-62. Montecino-Rodriguez E, Dorshkind K. PMID: 16782019.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    32. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006 Apr; 7(4):367-9. Smale ST, Dorshkind K. PMID: 16550201.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    33. Identification of a B-1 B cell-specified progenitor. Nat Immunol. 2006 Mar; 7(3):293-301. Montecino-Rodriguez E, Leathers H, Dorshkind K. PMID: 16429139.
      View in: PubMed   Mentions: 168     Fields:    Translation:AnimalsCells
    34. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol. 2006 Jan 15; 176(2):1007-12. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 16393987.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    35. Stromal cell-dependent growth of B-1 B cell progenitors in the absence of direct contact. Nat Protoc. 2006; 1(3):1140-4. Montecino-Rodriguez E, Dorshkind K. PMID: 17406395.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Reassessing the role of growth hormone and sex steroids in thymic involution. Clin Immunol. 2006 Jan; 118(1):117-23. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 16188505.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    37. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. PMID: 16148093.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Effects of aging on early B- and T-cell development. Immunol Rev. 2005 Jun; 205:7-17. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 15882341.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    39. Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol. 2004 Jul 01; 173(1):245-50. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 15210781.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    40. Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells. J Immunol. 2004 Apr 15; 172(8):4717-23. Dogusan Z, Montecino-Rodriguez E, Dorshkind K. PMID: 15067047.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. Got MLL? Definitive hematopoiesis requires MLL gene expression. Mol Cell. 2004 Mar 26; 13(6):765-6. Dorshkind K, Witte O. PMID: 15053868.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    42. Age-related changes in lymphocyte development and function. Nat Immunol. 2004 Feb; 5(2):133-9. Linton PJ, Dorshkind K. PMID: 14749784.
      View in: PubMed   Mentions: 370     Fields:    Translation:HumansAnimalsCells
    43. Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration. Clin Immunol. 2003 Nov; 109(2):197-202. Dorshkind K, Welniak L, Gault RA, Hixon J, Montecino-Rodriguez E, Horseman ND, Gertner JM, Murphy WJ. PMID: 14597218.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. To T or not to T: reassessing the common lymphoid progenitor. Nat Immunol. 2003 Feb; 4(2):100-1. Montecino-Rodriguez E, Dorshkind K. PMID: 12555090.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    45. Identification of B/macrophage progenitors in adult bone marrow. Semin Immunol. 2002 Dec; 14(6):371-6. Montecino-Rodriguez E, Dorshkind K. PMID: 12457609.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    46. Stem cells and lineage plasticity: the challenge to existing paradigms. Immunol Rev. 2002 Sep; 187:5-8. Dorshkind K. PMID: 12366678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    47. B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment. Blood. 2002 Nov 15; 100(10):3504-11. Hashimoto Y, Montecino-Rodriguez E, Leathers H, Stephan RP, Dorshkind K. PMID: 12393710.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. Optimizing hematopoietic recovery following bone marrow transplantation. J Clin Invest. 2002 Jun; 109(12):1527-8. Paquette R, Dorshkind K. PMID: 12070297.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    49. Multilineage development from adult bone marrow cells. Nat Immunol. 2002 Apr; 3(4):311-3. Dorshkind K. PMID: 11919565.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    50. Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation. Dev Immunol. 2002 Mar; 9(1):35-45. Lian ZX, Kita H, Okada T, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Ikehara S, Naiki M, Gershwin ME. PMID: 12353661.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    51. Impaired development of T lymphoid precursors from pluripotent hematopoietic stem cells in New Zealand Black mice. J Immunol. 2002 Jan 01; 168(1):81-6. Hashimoto Y, Montecino-Rodriguez E, Gershwin ME, Dorshkind K. PMID: 11751949.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    52. Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells. 2002; 20(4):293-300. Lian ZX, Okada T, Kita H, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Naiki M, Ikehara S, Gershwin ME. PMID: 12110698.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    53. Regulation of hematopoiesis by gap junction-mediated intercellular communication. J Leukoc Biol. 2001 Sep; 70(3):341-7. Montecino-Rodriguez E, Dorshkind K. PMID: 11527982.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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