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Dorshkind, Kenneth A

Title(s)Professor, Pathology And Laboratory Medicine
Phone69535, 69301
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    Collapse Research Activities and Funding
    Effects of Age-Related Changes in the Microenvironment on Patterns of Hematopoiesis
    NIH/NIA R01AG056480Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Effects of Aging on Lymphoid Biased Hematopoietic Stem Cells
    NIH/NIA R56AG050587Sep 15, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia
    NIH/NCI R21CA173028Feb 1, 2013 - Jan 31, 2015
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on T Lineage Aging
    NIH/NIA R01AG034875Mar 15, 2009 - Feb 28, 2014
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on B Lineage Sensescence
    NIH/NIA R01AG021450Aug 1, 2003 - Jun 30, 2008
    Role: Principal Investigator
    Immunopathology Training Grant
    NIH/NIAID T32AI052031Jun 1, 2003 - May 31, 2008
    Role: Principal Investigator
    MARK I IRRADIATOR (137C'S)
    NIH/NCRR S10RR014888Apr 1, 2000 - Mar 31, 2001
    Role: Principal Investigator
    T LINEAGE COMMITMENT AND DEVELOPMENT
    NIH/NHLBI R01HL060658Jul 10, 1998 - Jun 30, 2003
    Role: Principal Investigator
    LYMPHOPOIESIS DURING THYMIC INVOLUTION AND REGENERATION
    NIH/NIA R01AG013132Aug 15, 1997 - Dec 31, 1999
    Role: Principal Investigator
    IMMUNOBIOLOGY OF B CELL DIFFERENTIATION
    NIH/NIAID K04AI000843Sep 1, 1987 - Aug 31, 1992
    Role: Principal Investigator
    REGULATION OF HEMOPOIESIS BY STROMAL CELLS
    NIH/NHLBI R01HL036591Jul 1, 1986 - Jun 30, 1995
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH/NIAID R37AI021256Jul 1, 1984 - Nov 30, 2018
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH/NIAID R01AI021256Jul 1, 1984 - May 31, 1996
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA016042Dec 1, 1977 - Nov 30, 2019
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dorshkind K, Höfer T, Montecino-Rodriguez E, Pioli PD, Rodewald HR. Do haematopoietic stem cells age? Nat Rev Immunol. 2020 Mar; 20(3):196-202. PMID: 31740804.
      View in: PubMed
    2. Pioli PD, Casero D, Montecino-Rodriguez E, Morrison SL, Dorshkind K. Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow. Immunity. 2019 08 20; 51(2):351-366.e6. PMID: 31303400.
      View in: PubMed
    3. Ghosn E, Dorshkind K, Herzenberg LA, Holodick N, Kantor A, Montecino-Rodriguez E, Rothstein TL, Silverman GJ, Yang Y, Yoder MC, Yoshimoto M. B1 B cell progenitors. Science. 2019 04 19; 364(6437):248. PMID: 31000655.
      View in: PubMed
    4. Montecino-Rodriguez E, Kong Y, Casero D, Rouault A, Dorshkind K, Pioli PD. Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny. Stem Cell Reports. 2019 03 05; 12(3):584-596. PMID: 30799276.
      View in: PubMed
    5. Montecino-Rodriguez E, Casero D, Fice M, Le J, Dorshkind K. Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development. J Immunol. 2018 03 15; 200(6):2046-2056. PMID: 29436414.
      View in: PubMed
    6. Montecino-Rodriguez E, Fice M, Casero D, Berent-Maoz B, Barber CL, Dorshkind K. Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development. Immunity. 2016 09 20; 45(3):527-539. PMID: 27566938.
      View in: PubMed
    7. Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS One. 2015; 10(5):e0125414. PMID: 25933067.
      View in: PubMed
    8. Montecino-Rodriguez E, Li K, Fice M, Dorshkind K. Murine B-1 B cell progenitors initiate B-acute lymphoblastic leukemia with features of high-risk disease. J Immunol. 2014 Jun 01; 192(11):5171-8. PMID: 24752443.
      View in: PubMed
    9. Tidball JG, Dorshkind K, Wehling-Henricks M. Shared signaling systems in myeloid cell-mediated muscle regeneration. Development. 2014 Mar; 141(6):1184-96. PMID: 24595286.
      View in: PubMed
    10. Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013 Mar; 123(3):958-65. PMID: 23454758.
      View in: PubMed
    11. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14; 119(24):5715-21. PMID: 22555975.
      View in: PubMed
    12. Berent-Maoz B, Montecino-Rodriguez E, Dorshkind K. Genetic regulation of thymocyte progenitor aging. Semin Immunol. 2012 Oct; 24(5):303-8. PMID: 22559986.
      View in: PubMed
    13. Montecino-Rodriguez E, Dorshkind K. B-1 B cell development in the fetus and adult. Immunity. 2012 Jan 27; 36(1):13-21. PMID: 22284417.
      View in: PubMed
    14. Barber CL, Montecino-Rodriguez E, Dorshkind K. Developmental relationships between B-1 and B-2 progenitors. Cell Cycle. 2011 Nov 15; 10(22):3810-1. PMID: 22071629.
      View in: PubMed
    15. Montecino-Rodriguez E, Dorshkind K. Formation of B-1 B cells from neonatal B-1 transitional cells exhibits NF-?B redundancy. J Immunol. 2011 Dec 01; 187(11):5712-9. PMID: 22031760.
      View in: PubMed
    16. Barber CL, Montecino-Rodriguez E, Dorshkind K. Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13700-4. PMID: 21808010.
      View in: PubMed
    17. Yoshimoto M, Montecino-Rodriguez E, Ferkowicz MJ, Porayette P, Shelley WC, Conway SJ, Dorshkind K, Yoder MC. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1468-73. PMID: 21209332.
      View in: PubMed
    18. Dorshkind K. Not a split decision for human hematopoiesis. Nat Immunol. 2010 Jul; 11(7):569-70. PMID: 20562840.
      View in: PubMed
    19. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. PMID: 20562326.
      View in: PubMed
    20. Dorshkind K, Swain S. Age-associated declines in immune system development and function: causes, consequences, and reversal. Curr Opin Immunol. 2009 Aug; 21(4):404-7. PMID: 19632102.
      View in: PubMed
    21. Dorshkind K, Montecino-Rodriguez E, Signer RA. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62. PMID: 19104499.
      View in: PubMed
    22. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. PMID: 19056891.
      View in: PubMed
    23. Dorshkind K, Witte ON. Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes Dev. 2007 Sep 15; 21(18):2249-52. PMID: 17875661.
      View in: PubMed
    24. Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. PMID: 17554060.
      View in: PubMed
    25. Hardy RR, Kincade PW, Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity. 2007 Jun; 26(6):703-14. PMID: 17582343.
      View in: PubMed
    26. Dorshkind K, Montecino-Rodriguez E. Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential. Nat Rev Immunol. 2007 Mar; 7(3):213-9. PMID: 17318232.
      View in: PubMed
    27. Monroe JG, Dorshkind K. Fate decisions regulating bone marrow and peripheral B lymphocyte development. Adv Immunol. 2007; 95:1-50. PMID: 17869609.
      View in: PubMed
    28. Signer RA, Montecino-Rodriguez E, Dorshkind K. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol. 2007 May; 42(5):391-5. PMID: 17184948.
      View in: PubMed
    29. Montecino-Rodriguez E, Dorshkind K. New perspectives in B-1 B cell development and function. Trends Immunol. 2006 Sep; 27(9):428-33. PMID: 16861037.
      View in: PubMed
    30. Montecino-Rodriguez E, Dorshkind K. Evolving patterns of lymphopoiesis from embryogenesis through senescence. Immunity. 2006 Jun; 24(6):659-62. PMID: 16782019.
      View in: PubMed
    31. Smale ST, Dorshkind K. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006 Apr; 7(4):367-9. PMID: 16550201.
      View in: PubMed
    32. Montecino-Rodriguez E, Leathers H, Dorshkind K. Identification of a B-1 B cell-specified progenitor. Nat Immunol. 2006 Mar; 7(3):293-301. PMID: 16429139.
      View in: PubMed
    33. Min H, Montecino-Rodriguez E, Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol. 2006 Jan 15; 176(2):1007-12. PMID: 16393987.
      View in: PubMed
    34. Montecino-Rodriguez E, Dorshkind K. Stromal cell-dependent growth of B-1 B cell progenitors in the absence of direct contact. Nat Protoc. 2006; 1(3):1140-4. PMID: 17406395.
      View in: PubMed
    35. Min H, Montecino-Rodriguez E, Dorshkind K. Reassessing the role of growth hormone and sex steroids in thymic involution. Clin Immunol. 2006 Jan; 118(1):117-23. PMID: 16188505.
      View in: PubMed
    36. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. PMID: 16148093.
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    37. Min H, Montecino-Rodriguez E, Dorshkind K. Effects of aging on early B- and T-cell development. Immunol Rev. 2005 Jun; 205:7-17. PMID: 15882341.
      View in: PubMed
    38. Min H, Montecino-Rodriguez E, Dorshkind K. Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol. 2004 Jul 01; 173(1):245-50. PMID: 15210781.
      View in: PubMed
    39. Dogusan Z, Montecino-Rodriguez E, Dorshkind K. Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells. J Immunol. 2004 Apr 15; 172(8):4717-23. PMID: 15067047.
      View in: PubMed
    40. Dorshkind K, Witte O. Got MLL? Definitive hematopoiesis requires MLL gene expression. Mol Cell. 2004 Mar 26; 13(6):765-6. PMID: 15053868.
      View in: PubMed
    41. Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol. 2004 Feb; 5(2):133-9. PMID: 14749784.
      View in: PubMed
    42. Dorshkind K, Welniak L, Gault RA, Hixon J, Montecino-Rodriguez E, Horseman ND, Gertner JM, Murphy WJ. Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration. Clin Immunol. 2003 Nov; 109(2):197-202. PMID: 14597218.
      View in: PubMed
    43. Montecino-Rodriguez E, Dorshkind K. To T or not to T: reassessing the common lymphoid progenitor. Nat Immunol. 2003 Feb; 4(2):100-1. PMID: 12555090.
      View in: PubMed
    44. Montecino-Rodriguez E, Dorshkind K. Identification of B/macrophage progenitors in adult bone marrow. Semin Immunol. 2002 Dec; 14(6):371-6. PMID: 12457609.
      View in: PubMed
    45. Dorshkind K. Stem cells and lineage plasticity: the challenge to existing paradigms. Immunol Rev. 2002 Sep; 187:5-8. PMID: 12366678.
      View in: PubMed
    46. Hashimoto Y, Montecino-Rodriguez E, Leathers H, Stephan RP, Dorshkind K. B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment. Blood. 2002 Nov 15; 100(10):3504-11. PMID: 12393710.
      View in: PubMed
    47. Paquette R, Dorshkind K. Optimizing hematopoietic recovery following bone marrow transplantation. J Clin Invest. 2002 Jun; 109(12):1527-8. PMID: 12070297.
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    48. Dorshkind K. Multilineage development from adult bone marrow cells. Nat Immunol. 2002 Apr; 3(4):311-3. PMID: 11919565.
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    49. Lian ZX, Kita H, Okada T, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Ikehara S, Naiki M, Gershwin ME. Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation. Dev Immunol. 2002 Mar; 9(1):35-45. PMID: 12353661.
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    50. Hashimoto Y, Montecino-Rodriguez E, Gershwin ME, Dorshkind K. Impaired development of T lymphoid precursors from pluripotent hematopoietic stem cells in New Zealand Black mice. J Immunol. 2002 Jan 01; 168(1):81-6. PMID: 11751949.
      View in: PubMed
    51. Lian ZX, Okada T, Kita H, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Naiki M, Ikehara S, Gershwin ME. Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells. 2002; 20(4):293-300. PMID: 12110698.
      View in: PubMed
    52. Montecino-Rodriguez E, Dorshkind K. Regulation of hematopoiesis by gap junction-mediated intercellular communication. J Leukoc Biol. 2001 Sep; 70(3):341-7. PMID: 11527982.
      View in: PubMed
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