Kenneth A Dorshkind

Title(s)Professor, Pathology and Laboratory Medicine
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    Effects of Age-Related Changes in the Microenvironment on Patterns of Hematopoiesis
    NIH R01AG056480Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Effects of Aging on Lymphoid Biased Hematopoietic Stem Cells
    NIH R56AG050587Sep 15, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia
    NIH R21CA173028Feb 1, 2013 - Jan 31, 2016
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on T Lineage Aging
    NIH R01AG034875Mar 15, 2009 - Feb 28, 2014
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on B Lineage Sensescence
    NIH R01AG021450Aug 1, 2003 - Jul 31, 2012
    Role: Principal Investigator
    Immunopathology Training Grant
    NIH T32AI052031Jun 1, 2003 - May 31, 2008
    Role: Principal Investigator
    NIH S10RR014888Apr 1, 2000 - Mar 31, 2001
    Role: Principal Investigator
    NIH R01HL060658Jul 10, 1998 - Jun 30, 2003
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA016042Dec 1, 1996 - Mar 31, 2025
    Role: Co-Principal Investigator
    NIH R01AG013132May 15, 1995 - Dec 31, 1999
    Role: Principal Investigator
    NIH K04AI000843Sep 1, 1987 - Aug 31, 1992
    Role: Principal Investigator
    NIH R01HL036591Jul 1, 1986 - Jun 30, 1995
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH R37AI021256Jul 1, 1984 - Nov 30, 2018
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH R01AI021256Jul 1, 1984 - Dec 14, 2008
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Use of Busulfan to Condition Mice for Bone Marrow Transplantation. STAR Protoc. 2020 Dec 18; 1(3):100159. Montecino-Rodriguez E, Dorshkind K. PMID: 33377053.
      View in: PubMed   Mentions:
    2. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 10; 90:65-71.e1. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Do haematopoietic stem cells age? Nat Rev Immunol. 2020 03; 20(3):196-202. Dorshkind K, Höfer T, Montecino-Rodriguez E, Pioli PD, Rodewald HR. PMID: 31740804.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    4. Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow. Immunity. 2019 08 20; 51(2):351-366.e6. Pioli PD, Casero D, Montecino-Rodriguez E, Morrison SL, Dorshkind K. PMID: 31303400.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    5. B1 B cell progenitors. Science. 2019 04 19; 364(6437):248. Ghosn E, Dorshkind K, Herzenberg LA, Holodick N, Kantor A, Montecino-Rodriguez E, Rothstein TL, Silverman GJ, Yang Y, Yoder MC, Yoshimoto M. PMID: 31000655.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    6. Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny. Stem Cell Reports. 2019 03 05; 12(3):584-596. Montecino-Rodriguez E, Kong Y, Casero D, Rouault A, Dorshkind K, Pioli PD. PMID: 30799276.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development. J Immunol. 2018 03 15; 200(6):2046-2056. Montecino-Rodriguez E, Casero D, Fice M, Le J, Dorshkind K. PMID: 29436414.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development. Immunity. 2016 09 20; 45(3):527-539. Montecino-Rodriguez E, Fice M, Casero D, Berent-Maoz B, Barber CL, Dorshkind K. PMID: 27566938.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    9. The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2). PLoS One. 2015; 10(5):e0125414. Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K. PMID: 25933067.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Murine B-1 B cell progenitors initiate B-acute lymphoblastic leukemia with features of high-risk disease. J Immunol. 2014 Jun 01; 192(11):5171-8. Montecino-Rodriguez E, Li K, Fice M, Dorshkind K. PMID: 24752443.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    11. Shared signaling systems in myeloid cell-mediated muscle regeneration. Development. 2014 Mar; 141(6):1184-96. Tidball JG, Dorshkind K, Wehling-Henricks M. PMID: 24595286.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    12. Causes, consequences, and reversal of immune system aging. J Clin Invest. 2013 Mar; 123(3):958-65. Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K. PMID: 23454758.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    13. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012 Jun 14; 119(24):5715-21. Berent-Maoz B, Montecino-Rodriguez E, Signer RA, Dorshkind K. PMID: 22555975.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. Genetic regulation of thymocyte progenitor aging. Semin Immunol. 2012 Oct; 24(5):303-8. Berent-Maoz B, Montecino-Rodriguez E, Dorshkind K. PMID: 22559986.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. B-1 B cell development in the fetus and adult. Immunity. 2012 Jan 27; 36(1):13-21. Montecino-Rodriguez E, Dorshkind K. PMID: 22284417.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    16. Developmental relationships between B-1 and B-2 progenitors. . 2011 Nov 15; 10(22):3810-1. Barber CL, Montecino-Rodriguez E, Dorshkind K. PMID: 22071629.
      View in: PubMed   Mentions:
    17. Formation of B-1 B cells from neonatal B-1 transitional cells exhibits NF-?B redundancy. J Immunol. 2011 Dec 01; 187(11):5712-9. Montecino-Rodriguez E, Dorshkind K. PMID: 22031760.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    18. Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13700-4. Barber CL, Montecino-Rodriguez E, Dorshkind K. PMID: 21808010.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    19. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1468-73. Yoshimoto M, Montecino-Rodriguez E, Ferkowicz MJ, Porayette P, Shelley WC, Conway SJ, Dorshkind K, Yoder MC. PMID: 21209332.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    20. Not a split decision for human hematopoiesis. Nat Immunol. 2010 Jul; 11(7):569-70. Dorshkind K. PMID: 20562840.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia. Blood. 2010 Oct 07; 116(14):2522-30. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 20562326.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Age-associated declines in immune system development and function: causes, consequences, and reversal. Curr Opin Immunol. 2009 Aug; 21(4):404-7. Dorshkind K, Swain S. PMID: 19632102.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    23. The ageing immune system: is it ever too old to become young again? Nat Rev Immunol. 2009 Jan; 9(1):57-62. Dorshkind K, Montecino-Rodriguez E, Signer RA. PMID: 19104499.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimalsCells
    24. Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf. Genes Dev. 2008 Nov 15; 22(22):3115-20. Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K. PMID: 19056891.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    25. Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL. Genes Dev. 2007 Sep 15; 21(18):2249-52. Dorshkind K, Witte ON. PMID: 17875661.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    26. Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia. Blood. 2007 Sep 15; 110(6):1831-9. Signer RA, Montecino-Rodriguez E, Witte ON, McLaughlin J, Dorshkind K. PMID: 17554060.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    27. The protean nature of cells in the B lymphocyte lineage. Immunity. 2007 Jun; 26(6):703-14. Hardy RR, Kincade PW, Dorshkind K. PMID: 17582343.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    28. Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential. Nat Rev Immunol. 2007 Mar; 7(3):213-9. Dorshkind K, Montecino-Rodriguez E. PMID: 17318232.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    29. Fate decisions regulating bone marrow and peripheral B lymphocyte development. Adv Immunol. 2007; 95:1-50. Monroe JG, Dorshkind K. PMID: 17869609.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    30. Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol. 2007 May; 42(5):391-5. Signer RA, Montecino-Rodriguez E, Dorshkind K. PMID: 17184948.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    31. New perspectives in B-1 B cell development and function. Trends Immunol. 2006 Sep; 27(9):428-33. Montecino-Rodriguez E, Dorshkind K. PMID: 16861037.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    32. Evolving patterns of lymphopoiesis from embryogenesis through senescence. Immunity. 2006 Jun; 24(6):659-62. Montecino-Rodriguez E, Dorshkind K. PMID: 16782019.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006 Apr; 7(4):367-9. Smale ST, Dorshkind K. PMID: 16550201.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Identification of a B-1 B cell-specified progenitor. Nat Immunol. 2006 Mar; 7(3):293-301. Montecino-Rodriguez E, Leathers H, Dorshkind K. PMID: 16429139.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    35. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol. 2006 Jan 15; 176(2):1007-12. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 16393987.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    36. Stromal cell-dependent growth of B-1 B cell progenitors in the absence of direct contact. Nat Protoc. 2006; 1(3):1140-4. Montecino-Rodriguez E, Dorshkind K. PMID: 17406395.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Reassessing the role of growth hormone and sex steroids in thymic involution. Clin Immunol. 2006 Jan; 118(1):117-23. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 16188505.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    38. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. PMID: 16148093.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Effects of aging on early B- and T-cell development. Immunol Rev. 2005 Jun; 205:7-17. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 15882341.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    40. Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol. 2004 Jul 01; 173(1):245-50. Min H, Montecino-Rodriguez E, Dorshkind K. PMID: 15210781.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    41. Macrophages and stromal cells phagocytose apoptotic bone marrow-derived B lineage cells. J Immunol. 2004 Apr 15; 172(8):4717-23. Dogusan Z, Montecino-Rodriguez E, Dorshkind K. PMID: 15067047.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    42. Got MLL? Definitive hematopoiesis requires MLL gene expression. Mol Cell. 2004 Mar 26; 13(6):765-6. Dorshkind K, Witte O. PMID: 15053868.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    43. Age-related changes in lymphocyte development and function. Nat Immunol. 2004 Feb; 5(2):133-9. Linton PJ, Dorshkind K. PMID: 14749784.
      View in: PubMed   Mentions: 405     Fields:    Translation:HumansAnimalsCells
    44. Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration. Clin Immunol. 2003 Nov; 109(2):197-202. Dorshkind K, Welniak L, Gault RA, Hixon J, Montecino-Rodriguez E, Horseman ND, Gertner JM, Murphy WJ. PMID: 14597218.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. To T or not to T: reassessing the common lymphoid progenitor. Nat Immunol. 2003 Feb; 4(2):100-1. Montecino-Rodriguez E, Dorshkind K. PMID: 12555090.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    46. Identification of B/macrophage progenitors in adult bone marrow. Semin Immunol. 2002 Dec; 14(6):371-6. Montecino-Rodriguez E, Dorshkind K. PMID: 12457609.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    47. Stem cells and lineage plasticity: the challenge to existing paradigms. Immunol Rev. 2002 Sep; 187:5-8. Dorshkind K. PMID: 12366678.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    48. B-cell development in the thymus is limited by inhibitory signals from the thymic microenvironment. Blood. 2002 Nov 15; 100(10):3504-11. Hashimoto Y, Montecino-Rodriguez E, Leathers H, Stephan RP, Dorshkind K. PMID: 12393710.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. Optimizing hematopoietic recovery following bone marrow transplantation. J Clin Invest. 2002 Jun; 109(12):1527-8. Paquette R, Dorshkind K. PMID: 12070297.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    50. Multilineage development from adult bone marrow cells. Nat Immunol. 2002 Apr; 3(4):311-3. Dorshkind K. PMID: 11919565.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    51. Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation. Dev Immunol. 2002 Mar; 9(1):35-45. Lian ZX, Kita H, Okada T, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Ikehara S, Naiki M, Gershwin ME. PMID: 12353661.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    52. Impaired development of T lymphoid precursors from pluripotent hematopoietic stem cells in New Zealand Black mice. J Immunol. 2002 Jan 01; 168(1):81-6. Hashimoto Y, Montecino-Rodriguez E, Gershwin ME, Dorshkind K. PMID: 11751949.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    53. Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice. Stem Cells. 2002; 20(4):293-300. Lian ZX, Okada T, Kita H, Hsu T, Shultz LD, Dorshkind K, Ansari AA, Naiki M, Ikehara S, Gershwin ME. PMID: 12110698.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    54. Regulation of hematopoiesis by gap junction-mediated intercellular communication. J Leukoc Biol. 2001 Sep; 70(3):341-7. Montecino-Rodriguez E, Dorshkind K. PMID: 11527982.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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