Kenneth A Dorshkind

Title(s)Professor, Pathology and Laboratory Medicine
ORCID ORCID Icon0000-0002-9005-631X Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Washington, Seattle, WAPh.D.09/01/1Hematopoiesis

    Collapse Research 
    Collapse Research Activities and Funding
    Effects of Age-Related Changes in the Microenvironment on Patterns of Hematopoiesis
    NIH R01AG056480Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    Effects of Aging on Lymphoid Biased Hematopoietic Stem Cells
    NIH R56AG050587Sep 15, 2016 - Aug 31, 2017
    Role: Principal Investigator
    Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia
    NIH R21CA173028Feb 1, 2013 - Jan 31, 2016
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on T Lineage Aging
    NIH R01AG034875Mar 15, 2009 - Feb 28, 2014
    Role: Principal Investigator
    Effects of p16Ink4a and Arf on B Lineage Sensescence
    NIH R01AG021450Jul 1, 2003 - Jul 31, 2012
    Role: Principal Investigator
    Immunopathology Training Grant
    NIH T32AI052031Jun 1, 2003 - May 31, 2008
    Role: Principal Investigator
    NIH S10RR014888Apr 1, 2000 - Mar 31, 2001
    Role: Principal Investigator
    NIH R01HL060658Jul 10, 1998 - Jun 30, 2003
    Role: Principal Investigator
    NIH R01AG013132May 15, 1995 - Dec 31, 1999
    Role: Principal Investigator
    NIH K04AI000843Sep 1, 1987 - Aug 31, 1992
    Role: Principal Investigator
    NIH R01HL036591Jul 1, 1986 - Jun 30, 1995
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH R37AI021256Jul 1, 1984 - Nov 30, 2018
    Role: Principal Investigator
    Immunobiology of B Cell Differentiation
    NIH R01AI021256Jul 1, 1984 - Dec 14, 2008
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA016042Mar 31, 2025
    Role: Co-Principal Investigator

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    Collapse Featured Publications

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Envelope protein-specific B cell receptors direct lentiviral vector tropism in vivo. Mol Ther. 2024 Mar 06. Takano KA, Wong AAL, Brown R, Situ K, Chua BA, Abu AE, Pham TT, Reyes GC, Ramachandran S, Kamata M, Li MMH, Wu TT, Rao DS, Arumugaswami V, Dorshkind K, Cole S, Morizono K. PMID: 38449314.
      View in: PubMed   Mentions:    Fields:    
    2. Layered immune system development in mice and humans. Immunol Rev. 2023 05; 315(1):5-10. Dorshkind K, Crooks G. PMID: 36960956.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. The layered development of mouse B and T Cells. Immunol Rev. 2023 05; 315(1):79-88. Montecino-Rodriguez E, Dorshkind K. PMID: 36583420.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Myeloid cell-specific mutation of Spi1 selectively reduces M2-biased macrophage numbers in skeletal muscle, reduces age-related muscle fibrosis and prevents sarcopenia. Aging Cell. 2022 10; 21(10):e13690. Wang Y, Welc SS, Wehling-Henricks M, Kong Y, Thomas C, Montecino-Rodriguez E, Dorshkind K, Tidball JG. PMID: 36098370; PMCID: PMC9577952.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Use of Busulfan to Condition Mice for Bone Marrow Transplantation. STAR Protoc. 2020 12 18; 1(3):100159. Montecino-Rodriguez E, Dorshkind K. PMID: 33377053; PMCID: PMC7757355.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    6. Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature. Exp Hematol. 2020 10; 90:65-71.e1. Fitch B, Roy R, Geng H, Montecino-Rodriguez E, Bengtsson H, Gaillard C, Hiam K, Casero D, Olshen AB, Dorshkind K, Kogan SC. PMID: 32946981; PMCID: PMC7606616.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    7. Do haematopoietic stem cells age? Nat Rev Immunol. 2020 03; 20(3):196-202. Dorshkind K, Höfer T, Montecino-Rodriguez E, Pioli PD, Rodewald HR. PMID: 31740804; PMCID: PMC7879798.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    8. Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow. Immunity. 2019 08 20; 51(2):351-366.e6. Pioli PD, Casero D, Montecino-Rodriguez E, Morrison SL, Dorshkind K. PMID: 31303400; PMCID: PMC6703913.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    9. B1 B cell progenitors. Science. 2019 04 19; 364(6437):248. Ghosn E, Dorshkind K, Herzenberg LA, Holodick N, Kantor A, Montecino-Rodriguez E, Rothstein TL, Silverman GJ, Yang Y, Yoder MC, Yoshimoto M. PMID: 31000655; PMCID: PMC7257805.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    10. Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny. Stem Cell Reports. 2019 03 05; 12(3):584-596. Montecino-Rodriguez E, Kong Y, Casero D, Rouault A, Dorshkind K, Pioli PD. PMID: 30799276; PMCID: PMC6409485.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    11. Differential Expression of PU.1 and Key T Lineage Transcription Factors Distinguishes Fetal and Adult T Cell Development. J Immunol. 2018 03 15; 200(6):2046-2056. Montecino-Rodriguez E, Casero D, Fice M, Le J, Dorshkind K. PMID: 29436414; PMCID: PMC5840016.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    12. Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development. Immunity. 2016 09 20; 45(3):527-539. Montecino-Rodriguez E, Fice M, Casero D, Berent-Maoz B, Barber CL, Dorshkind K. PMID: 27566938; PMCID: PMC5033716.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    13. Reevaluating current models of thymic involution. Semin Immunol. 2005 Oct; 17(5):356-61. Montecino-Rodriquez E, Min H, Dorshkind K. PMID: 15967677.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
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