Dinesh S Rao

Title(s)Associate Professor, Pathology and Laboratory Medicine
SchoolMedicine
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    Dinesh S. Rao is a physician scientist with interests in the molecular basis of hematologic malignancies. He received a B.S. summa cum laude in Biochemistry and an M.D. from Case Western Reserve University, Cleveland, USA. During this time he developed a deep interest in the pathogenesis of cancer, completing several projects in cancer research during medical school, and went on to a research fellowship at the University of Michigan. There, he made a seminal discovery implicating clathrin mediated trafficking of growth factor receptor tyrosine kinases in oncogenic transformation. He then combined clinical training in the pathology of hematologic diseases with further research training in the laboratory of Nobel laureate David Baltimore at Caltech, making and contributing to important discoveries on microRNAs in the immune system. The Rao lab at UCLA, established in 2010, has been interested in studying the mechanisms of post-transcriptional gene regulation in hematopoietic development, the immune system and in hematologic malignancy. His research work has highlighted startling new mechanisms involving RNA binding proteins and non-coding RNA in oncogenesis, and the lab is focused on molecular biological underpinnings of post-transcriptional gene regulation and translational work to develop novel therapeutic approaches. In addition to running a vibrant research laboratory, he manages a busy diagnostic service in leukemia and lymphoma molecular pathology.

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    Protein-RNA interactions in cancer
    NIH R01CA264986Aug 1, 2021 - Jul 31, 2026
    Role: Co-Principal Investigator
    Pathogenetic roles of USO1 in leukemogenesis
    NIH R03CA251845Mar 1, 2021 - Feb 28, 2023
    Role: Principal Investigator
    RNA-Binding Proteins in the control of B-Cell Development
    NIH R21AI132869Jun 20, 2017 - May 31, 2019
    Role: Principal Investigator
    Unraveling the Function of RNA-Binding proteins in B-lympoblastic Leukemia
    NIH R21CA197441Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator
    Function on Non-Coding RNA, MALAT1, in B-cell development and Lymphoma
    NIH R03CA175426Jan 1, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Characterizing tumor suppressive functions of microRNAs in B-cell neoplasia
    NIH R01CA166450Jan 1, 2013 - Dec 31, 2017
    Role: Principal Investigator
    Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasia
    NIH K08CA133521Sep 30, 2009 - Aug 31, 2014
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The long non-coding RNA CDK6-AS1 overexpression impacts on acute myeloid leukemia differentiation and mitochondrial dynamics. iScience. 2021 Nov 19; 24(11):103350. Porcù E, Benetton M, Bisio V, Da Ros A, Tregnago C, Borella G, Zanon C, Bordi M, Germano G, Manni S, Campello S, Rao DS, Locatelli F, Pigazzi M. PMID: 34816103; PMCID: PMC8591413.
      View in: PubMed   Mentions:
    2. The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis. Leukemia. 2022 01; 36(1):68-79. Tran TM, Philipp J, Bassi JS, Nibber N, Draper JM, Lin TL, Palanichamy JK, Jaiswal AK, Silva O, Paing M, King J, Katzman S, Sanford JR, Rao DS. PMID: 34321607; PMCID: PMC8727287.
      View in: PubMed   Mentions:
    3. Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia. Sci Rep. 2021 06 23; 11(1):13158. Jaiswal AK, Truong H, Tran TM, Lin TL, Casero D, Alberti MO, Rao DS. PMID: 34162911; PMCID: PMC8222245.
      View in: PubMed   Mentions:
    4. Microsized inflammaging protects stem cells. Blood. 2020 06 18; 135(25):2204-2205. O'Connell RM, Rao DS. PMID: 32556135; PMCID: PMC7316214.
      View in: PubMed   Mentions:
    5. T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation. J Immunol. 2020 04 15; 204(8):2064-2075. Ekiz HA, Ramstead AG, Lee SH, Nelson MC, Bauer KM, Wallace JA, Hu R, Round JL, Rutter J, Drummond MJ, Rao DS, O'Connell RM. PMID: 32161096; PMCID: PMC7325601.
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    6. Wild-type Kras expands and exhausts hematopoietic stem cells. JCI Insight. 2018 06 07; 3(11). Sasine JP, Himburg HA, Termini CM, Roos M, Tran E, Zhao L, Kan J, Li M, Zhang Y, de Barros SC, Rao DS, Counter CM, Chute JP. PMID: 29875320; PMCID: PMC6124423.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity. J Clin Invest. 2017 Oct 02; 127(10):3702-3716. Li B, Wang X, Choi IY, Wang YC, Liu S, Pham AT, Moon H, Smith DJ, Rao DS, Boldin MP, Yang L. PMID: 28872459; PMCID: PMC5617680.
      View in: PubMed   Mentions:
    8. The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia. Mol Cancer. 2017 07 19; 16(1):126. Fernando TR, Contreras JR, Zampini M, Rodriguez-Malave NI, Alberti MO, Anguiano J, Tran TM, Palanichamy JK, Gajeton J, Ung NM, Aros CJ, Waters EV, Casero D, Basso G, Pigazzi M, Rao DS. PMID: 28724437; PMCID: PMC5517805.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    9. miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. Blood. 2017 06 08; 129(23):3074-3086. Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander M, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth WP, Rao DS, Miles RR, Round JL, Deininger MW, O'Connell RM. PMID: 28432220; PMCID: PMC5465836.
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    10. Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a. Front Immunol. 2016; 7:670. King JK, Ung NM, Paing MH, Contreras JR, Alberti MO, Fernando TR, Zhang K, Pellegrini M, Rao DS. PMID: 28138326; PMCID: PMC5237642.
      View in: PubMed   Mentions: 10     Fields:    
    11. Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth. PLoS One. 2016; 11(4):e0153689. Wallace J, Hu R, Mosbruger TL, Dahlem TJ, Stephens WZ, Rao DS, Round JL, O'Connell RM. PMID: 27081855; PMCID: PMC4833428.
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    12. RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation. J Clin Invest. 2016 Apr 01; 126(4):1495-511. Palanichamy JK, Tran TM, Howard JM, Contreras JR, Fernando TR, Sterne-Weiler T, Katzman S, Toloue M, Yan W, Basso G, Pigazzi M, Sanford JR, Rao DS. PMID: 26974154; PMCID: PMC4811152.
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    13. BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer. 2015 Dec 22; 14:214. Rodríguez-Malavé NI, Fernando TR, Patel PC, Contreras JR, Palanichamy JK, Tran TM, Anguiano J, Davoren MJ, Alberti MO, Pioli KT, Sandoval S, Crooks GM, Rao DS. PMID: 26694754; PMCID: PMC4688921.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    14. Long noncoding RNAs in hematopoietic malignancies. Brief Funct Genomics. 2016 May; 15(3):227-38. Rodríguez-Malavé NI, Rao DS. PMID: 26612601.
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    15. MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1. Oncotarget. 2015 May 10; 6(13):11023-37. Contreras JR, Palanichamy JK, Tran TM, Fernando TR, Rodriguez-Malave NI, Goswami N, Arboleda VA, Casero D, Rao DS. PMID: 25906746; PMCID: PMC4484436.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    16. LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia. Mol Cancer Res. 2015 May; 13(5):839-51. Fernando TR, Rodriguez-Malave NI, Waters EV, Yan W, Casero D, Basso G, Pigazzi M, Rao DS. PMID: 25681502; PMCID: PMC4433429.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    17. miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014 Oct 16; 41(4):605-19. Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM. PMID: 25367574; PMCID: PMC4657560.
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    18. Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-?B gene network. Cell Rep. 2014 Sep 11; 8(5):1328-38. Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, Komurov K, Weirauch MT, Cancelas JA, Maciejewski JP, Starczynowski DT. PMID: 25199827; PMCID: PMC4237069.
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    19. miRNA dysregulation in cancer: towards a mechanistic understanding. Front Genet. 2014; 5:54. Palanichamy JK, Rao DS. PMID: 24672539; PMCID: PMC3957189.
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    20. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med. 2014 Mar; 20(3):296-300. Balazs AB, Ouyang Y, Hong CM, Chen J, Nguyen SM, Rao DS, An DS, Baltimore D. PMID: 24509526; PMCID: PMC3990417.
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    21. Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat Biotechnol. 2013 Jul; 31(7):647-52. Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D. PMID: 23728362; PMCID: PMC4030719.
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    22. MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. Elife. 2013 May 21; 2:e00537. Zhao JL, Rao DS, O'Connell RM, Garcia-Flores Y, Baltimore D. PMID: 23705069; PMCID: PMC3660742.
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    23. MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation. Haematologica. 2013 Apr; 98(4):602-10. Pigazzi M, Manara E, Bresolin S, Tregnago C, Beghin A, Baron E, Giarin E, Cho EC, Masetti R, Rao DS, Sakamoto KM, Basso G. PMID: 23100280; PMCID: PMC3659992.
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    24. Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Blood. 2012 Nov 29; 120(23):4571-82. Hur EM, Patel SN, Shimizu S, Rao DS, Gnanapragasam PN, An DS, Yang L, Baltimore D. PMID: 23065154; PMCID: PMC3512234.
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    25. MicroRNAs in B cell development and malignancy. J Hematol Oncol. 2012 Mar 08; 5:7. Fernando TR, Rodriguez-Malave NI, Rao DS. PMID: 22401860; PMCID: PMC3338094.
      View in: PubMed   Mentions:
    26. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4233-8. Chaudhuri AA, So AY, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O'Connell RM, Baltimore D. PMID: 22366319; PMCID: PMC3306721.
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    27. microRNA regulation of inflammatory responses. Annu Rev Immunol. 2012; 30:295-312. O'Connell RM, Rao DS, Baltimore D. PMID: 22224773.
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    28. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2011 Nov 30; 481(7379):81-4. Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D. PMID: 22139420; PMCID: PMC3253190.
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    29. MicroRNA function in myeloid biology. Blood. 2011 Sep 15; 118(11):2960-9. O'Connell RM, Zhao JL, Rao DS. PMID: 21725054; PMCID: PMC3175776.
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    30. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9184-9. Zhao JL, Rao DS, Boldin MP, Taganov KD, O'Connell RM, Baltimore D. PMID: 21576471; PMCID: PMC3107319.
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    31. miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med. 2011 Jun 06; 208(6):1189-201. Boldin MP, Taganov KD, Rao DS, Yang L, Zhao JL, Kalwani M, Garcia-Flores Y, Luong M, Devrekanli A, Xu J, Sun G, Tay J, Linsley PS, Baltimore D. PMID: 21555486; PMCID: PMC3173243.
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    32. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity. 2010 Oct 29; 33(4):607-19. O'Connell RM, Kahn D, Gibson WS, Round JL, Scholz RL, Chaudhuri AA, Kahn ME, Rao DS, Baltimore D. PMID: 20888269; PMCID: PMC2966521.
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    33. Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PLoS One. 2010 Aug 06; 5(8):e12009. O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D. PMID: 20700454; PMCID: PMC2917362.
      View in: PubMed   Mentions:
    34. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14235-40. O'Connell RM, Chaudhuri AA, Rao DS, Gibson WS, Balazs AB, Baltimore D. PMID: 20660734; PMCID: PMC2922591.
      View in: PubMed   Mentions:
    35. MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity. 2010 Jul 23; 33(1):48-59. Rao DS, O'Connell RM, Chaudhuri AA, Garcia-Flores Y, Geiger TL, Baltimore D. PMID: 20598588; PMCID: PMC2911227.
      View in: PubMed   Mentions:
    36. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 2010 Feb; 10(2):111-22. O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. PMID: 20098459.
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    37. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7113-8. O'Connell RM, Chaudhuri AA, Rao DS, Baltimore D. PMID: 19359473; PMCID: PMC2678424.
      View in: PubMed   Mentions:
    38. MicroRNAs: new regulators of immune cell development and function. Nat Immunol. 2008 Aug; 9(8):839-45. Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. PMID: 18645592.
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    39. Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia. Leuk Res. 2008 Nov; 32(11):1770-5. Pullarkat ST, Vardiman JW, Slovak ML, Rao DS, Rao NP, Bedell V, Said JW. PMID: 18417213.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med. 2008 Mar 17; 205(3):585-94. O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J, Paquette RL, Baltimore D. PMID: 18299402; PMCID: PMC2275382.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansAnimalsCells
    41. Small lymphoid proliferations in extranodal locations. Arch Pathol Lab Med. 2007 Mar; 131(3):383-96. Rao DS, Said JW. PMID: 17516741.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    42. An inverse relation between COX-2 and E-cadherin expression correlates with aggressive histologic features in prostate cancer. Appl Immunohistochem Mol Morphol. 2006 Dec; 14(4):375-83. Rao DS, Gui D, Koski ME, Popoviciu LM, Wang H, Reiter RE, Said JW. PMID: 17122632.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. Computed tomography calcium quantification as a measure of atherosclerotic plaque morphology and stability. Invest Radiol. 2006 Sep; 41(9):674-80. Pham PH, Rao DS, Vasunilashorn F, Fishbein MC, Goldin JG. PMID: 16896302.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    44. Primary extranodal nasal-type natural killer/T-cell lymphoma of the brain: a case report. Hum Pathol. 2006 Jun; 37(6):769-72. Kaluza V, Rao DS, Said JW, de Vos S. PMID: 16733220.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    45. Cough-induced hemiplegic migraine with impaired consciousness in cystic fibrosis. Pediatr Pulmonol. 2006 Feb; 41(2):171-6. Rao DS, Infeld MD, Stern RC, Chelimsky TC. PMID: 16372353.
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    46. Determinants of plaque instability in atherosclerotic vascular disease. Cardiovasc Pathol. 2005 Nov-Dec; 14(6):285-93. Rao DS, Goldin JG, Fishbein MC. PMID: 16286036.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    47. Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet. 2004 Apr 15; 13(8):851-67. Oravecz-Wilson KI, Kiel MJ, Li L, Rao DS, Saint-Dic D, Kumar PD, Provot MM, Hankenson KD, Reddy VN, Lieberman AP, Morrison SJ, Ross TS. PMID: 14998932.
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    48. HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. J Biol Chem. 2004 Apr 02; 279(14):14294-306. Hyun TS, Rao DS, Saint-Dic D, Michael LE, Kumar PD, Bradley SV, Mizukami IF, Oravecz-Wilson KI, Ross TS. PMID: 14732715.
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    49. Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer Cell. 2003 May; 3(5):471-82. Rao DS, Bradley SV, Kumar PD, Hyun TS, Saint-Dic D, Oravecz-Wilson K, Kleer CG, Ross TS. PMID: 12781365.
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    50. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J Clin Invest. 2002 Aug; 110(3):351-60. Rao DS, Hyun TS, Kumar PD, Mizukami IF, Rubin MA, Lucas PC, Sanda MG, Ross TS. PMID: 12163454; PMCID: PMC151092.
      View in: PubMed   Mentions:
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