Shelly Lu

Title(s)Professor-in-Residence, Medicine
Phone(310) 423-5692
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity. Cell Death Dis. 2021 May 28; 12(6):555. Fernández-Tussy P, Rodríguez-Agudo R, Fernández-Ramos D, Barbier-Torres L, Zubiete-Franco I, Davalillo SL, Herraez E, Goikoetxea-Usandizaga N, Lachiondo-Ortega S, Simón J, Lopitz-Otsoa F, Juan VG, McCain MV, Perugorria MJ, Mabe J, Navasa N, Rodrigues CMP, Fabregat I, Boix L, Sapena V, Anguita J, Lu SC, Mato JM, Banales JM, Villa E, Reeves HL, Bruix J, Reig M, Marin JJG, Delgado TC, Martínez-Chantar ML. PMID: 34050139.
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    2. The Mortality and Overall Survival Trends of Primary Liver Cancer in the United States. J Natl Cancer Inst. 2021 May 19. Lee YT, Wang JJ, Luu M, Noureddin M, Kosari K, Agopian VG, Rich NE, Lu SC, Tseng HR, Nissen NN, Singal AG, Yang JD. PMID: 34010422.
      View in: PubMed   Mentions: 1     Fields:    
    3. Transarterial radioembolization versus systemic treatment for hepatocellular carcinoma with macrovascular invasion: Analysis of the US National Cancer Database. J Nucl Med. 2021 Apr 09. Ahn JC, Lauzon M, Luu M, Friedman ML, Kosari K, Nissen N, Lu SC, Roberts LR, Singal AG, Yang JD. PMID: 33837067.
      View in: PubMed   Mentions:    Fields:    
    4. Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury. JHEP Rep. 2021 Jun; 3(3):100276. Iruzubieta P, Goikoetxea-Usandizaga N, Barbier-Torres L, Serrano-Maciá M, Fernández-Ramos D, Fernández-Tussy P, Gutiérrez-de-Juan V, Lachiondo-Ortega S, Simon J, Bravo M, Lopitz-Otsoa F, Robles M, Ferre-Aracil C, Varela-Rey M, Elguezabal N, Calleja JL, Lu SC, Milkiewicz M, Milkiewicz P, Anguita J, Monte MJ, Marin JJG, López-Hoyos M, Delgado TC, Rincón M, Crespo J, Martínez-Chantar ML. PMID: 33997750.
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    5. State-Level HCC Incidence and Association With Obesity and Physical Activity in the United States. Hepatology. 2021 Mar 17. Lee YT, Wang JJ, Luu M, Tseng HR, Rich NE, Lu SC, Nissen NN, Noureddin M, Singal AG, Yang JD. PMID: 33728665.
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    6. Detection of Circulating Tumor Cells and Their Implications as a Biomarker for Diagnosis, Prognostication, and Therapeutic Monitoring in Hepatocellular Carcinoma. Hepatology. 2021 01; 73(1):422-436. Ahn JC, Teng PC, Chen PJ, Posadas E, Tseng HR, Lu SC, Yang JD. PMID: 32017145.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    7. Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E. PMID: 33443222.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Metabolic Landscape of the Mouse Liver by Quantitative 31 P Nuclear Magnetic Resonance Analysis of the Phosphorome. Hepatology. 2020 Dec 07. Bernardo-Seisdedos G, Bilbao J, Fernández-Ramos D, Lopitz-Otsoa F, Gutierrez de Juan V, Bizkarguenaga M, Mateos B, Fondevila MF, Abril-Fornaguera J, Diercks T, Lu SC, Nogueiras R, Mato JM, Millet O. PMID: 33284502.
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    9. Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis. Transplant Direct. 2020 Nov; 6(11):e612. Noureddin N, Yang JD, Alkhouri N, Noreen SM, Toll AE, Todo T, Ayoub W, Kuo A, Voidonikolas G, Kotler HG, Pelphrey MD, Durand BJ, Kosari K, Brennan TV, Kim I, Klein AS, Seki E, Nissen NN, Lu SC, Sundaram V, Noureddin M. PMID: 33134488.
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    10. Reciprocal Regulation Between Forkhead Box M1/NF-?B and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700. Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC. PMID: 32080887.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. Hepatocellular Carcinoma: Updates in Pathogenesis, Detection and Treatment. Cancers (Basel). 2020 Sep 23; 12(10). Martínez-Chantar ML, Avila MA, Lu SC. PMID: 32977536.
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    12. Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease. J Proteome Res. 2020 10 02; 19(10):4163-4178. Robinson AE, Binek A, Venkatraman V, Searle BC, Holewinski RJ, Rosenberger G, Parker SJ, Basisty N, Xie X, Lund PJ, Saxena G, Mato JM, Garcia BA, Schilling B, Lu SC, Van Eyk JE. PMID: 32966080.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. World J Gastroenterol. 2020 Sep 14; 26(34):5101-5117. Fernández-Ramos D, Lopitz-Otsoa F, Delacruz-Villar L, Bilbao J, Pagano M, Mosca L, Bizkarguenaga M, Serrano-Macia M, Azkargorta M, Iruarrizaga-Lejarreta M, Sot J, Tsvirkun D, van Liempd SM, Goni FM, Alonso C, Martínez-Chantar ML, Elortza F, Hayardeny L, Lu SC, Mato JM. PMID: 32982112.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    14. Factors Associated With Detection and Survival of T1 Hepatocellular Carcinoma in the United States: National Cancer Database Analysis. J Natl Compr Canc Netw. 2020 09; 18(9):1210-1220. Yang JD, Luu M, Singal AG, Noureddin M, Kuo A, Ayoub WS, Sundaram V, Kotler H, Kim IK, Todo T, Voidonikolas G, Brennan TV, Kosari K, Klein AS, Hendifar A, Lu SC, Nissen NN, Gong J. PMID: 32886898.
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    15. PINE: An Automation Tool to Extract and Visualize Protein-Centric Functional Networks. J Am Soc Mass Spectrom. 2020 Jul 01; 31(7):1410-1421. Sundararaman N, Go J, Robinson AE, Mato JM, Lu SC, Van Eyk JE, Venkatraman V. PMID: 32463229.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Chemotherapy-associated liver injury in colorectal cancer. Therap Adv Gastroenterol. 2020; 13:1756284820924194. Gangi A, Lu SC. PMID: 32547639.
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    17. Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly. Cell Metab. 2020 03 03; 31(3):605-622.e10. Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano-Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML. PMID: 32084378.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Prohibitin 1 in liver injury and cancer. Exp Biol Med (Maywood). 2020 03; 245(5):385-394. Barbier-Torres L, Lu SC. PMID: 32077311.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Current status of hepatocellular carcinoma detection: screening strategies and novel biomarkers. Ther Adv Med Oncol. 2019; 11:1758835919869120. Ayoub WS, Steggerda J, Yang JD, Kuo A, Sundaram V, Lu SC. PMID: 31523283.
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    20. Methionine adenosyltransferases in liver cancer. World J Gastroenterol. 2019 Aug 21; 25(31):4300-4319. Murray B, Barbier-Torres L, Fan W, Mato JM, Lu SC. PMID: 31496615.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease. Mol Metab. 2019 11; 29:40-54. Fernández-Tussy P, Fernández-Ramos D, Lopitz-Otsoa F, Simón J, Barbier-Torres L, Gomez-Santos B, Nuñez-Garcia M, Azkargorta M, Gutiérrez-de Juan V, Serrano-Macia M, Rodríguez-Agudo R, Iruzubieta P, Anguita J, Castro RE, Champagne D, Rincón M, Elortza F, Arslanow A, Krawczyk M, Lammert F, Kirchmeyer M, Behrmann I, Crespo J, Lu SC, Mato JM, Varela-Rey M, Aspichueta P, Delgado TC, Martínez-Chantar ML. PMID: 31668391.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. World J Gastroenterol. 2019 Jun 28; 25(24):3009-3020. Mato JM, Alonso C, Noureddin M, Lu SC. PMID: 31293337.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. Methionine Adenosyltransferase a1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression. Hepatology. 2019 12; 70(6):2018-2034. Murray B, Peng H, Barbier-Torres L, Robinson AE, Li TWH, Fan W, Tomasi ML, Gottlieb RA, Van Eyk J, Lu Z, Martínez-Chantar ML, Liangpunsakul S, Skill NJ, Mato JM, Lu SC. PMID: 31077594.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    24. Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Sci Transl Med. 2019 06 12; 11(496). Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E. PMID: 31189722.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 11; 70(5):1582-1599. Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. PMID: 31044438.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. J Biol Chem. 2019 02 08; 294(6):1984-1996. Yang JW, Murray B, Barbier-Torres L, Liu T, Liu Z, Yang H, Fan W, Wang J, Li Y, Seki E, Mato JM, Lu SC. PMID: 30523154.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells. Hepatol Commun. 2018 Dec; 2(12):1583-1600. Mavila N, Tang Y, Berlind J, Ramani K, Wang J, Mato JM, Lu SC. PMID: 30556043.
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    28. MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis. Cell Death Dis. 2018 09 20; 9(10):958. Fernández-Ramos D, Fernández-Tussy P, Lopitz-Otsoa F, Gutiérrez-de-Juan V, Navasa N, Barbier-Torres L, Zubiete-Franco I, Simón J, Fernández AF, Arbelaiz A, Aransay AM, Lavín JL, Beraza N, Perugorria MJ, Banales JM, Villa E, Fraga MF, Anguita J, Avila MA, Berasain C, Iruzibieta P, Crespo J, Lu SC, Varela-Rey M, Mato JM, Delgado TC, Martínez-Chantar ML. PMID: 30237481.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. Liver cancer-associated changes to the proteome: what deserves clinical focus? Expert Rev Proteomics. 2018 09; 15(9):749-756. Mato JM, Elortza F, Lu SC, Brun V, Paradela A, Corrales FJ. PMID: 30204005.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. NASH Leading Cause of Liver Transplant in Women: Updated Analysis of Indications For Liver Transplant and Ethnic and Gender Variances. Am J Gastroenterol. 2018 11; 113(11):1649-1659. Noureddin M, Vipani A, Bresee C, Todo T, Kim IK, Alkhouri N, Setiawan VW, Tran T, Ayoub WS, Lu SC, Klein AS, Sundaram V, Nissen NN. PMID: 29880964.
      View in: PubMed   Mentions: 86     Fields:    Translation:Humans
    31. Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018 08; 155(2):557-571.e14. Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC. PMID: 29733835.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    32. Metabolomic-based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts. Hepatol Commun. 2018 Jul; 2(7):807-820. Mayo R, Crespo J, Martínez-Arranz I, Banales JM, Arias M, Mincholé I, Aller de la Fuente R, Jimenez-Agüero R, Alonso C, de Luis DA, Vitek L, Stritesky J, Caballería J, Romero-Gómez M, Martín-Duce A, Mugüerza Huguet JM, Busteros-Moraza JI, Idowu MO, Castro A, Martínez-Chantar ML, Ortiz P, Bruha R, Lu SC, Bedossa P, Noureddin M, Sanyal AJ, Mato JM. PMID: 30027139.
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    33. Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals. World J Gastroenterol. 2018 Mar 21; 24(11):1269-1277. Noureddin M, Wong MM, Todo T, Lu SC, Sanyal AJ, Mena EA. PMID: 29568207.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    34. The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat Commun. 2017 12 12; 8(1):2068. Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincón M, Martínez-Chantar ML. PMID: 29233977.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    35. Methionine adenosyltransferases in cancers: Mechanisms of dysregulation and implications for therapy. Exp Biol Med (Maywood). 2018 01; 243(2):107-117. Maldonado LY, Arsene D, Mato JM, Lu SC. PMID: 29141455.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    36. Role of Aramchol in steatohepatitis and fibrosis in mice. Hepatol Commun. 2017 Nov; 1(9):911-927. Iruarrizaga-Lejarreta M, Varela-Rey M, Fernández-Ramos D, Martínez-Arranz I, Delgado TC, Simon J, Juan VG, delaCruz-Villar L, Azkargorta M, Lavin JL, Mayo R, Van Liempd SM, Aurrekoetxea I, Buqué X, Cave DD, Peña A, Rodríguez-Cuesta J, Aransay AM, Elortza F, Falcón-Pérez JM, Aspichueta P, Hayardeny L, Noureddin M, Sanyal AJ, Alonso C, Anguita J, Martínez-Chantar ML, Lu SC, Mato JM. PMID: 29159325.
      View in: PubMed   Mentions:
    37. Methionine adenosyltransferases in liver health and diseases. Liver Res. 2017 Sep; 1(2):103-111. Ramani K, Lu SC. PMID: 29170720.
      View in: PubMed   Mentions:
    38. S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Oncotarget. 2017 Oct 03; 8(45):78851-78869. Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. PMID: 29108270.
      View in: PubMed   Mentions: 10     Fields:    
    39. A morphological method for ammonia detection in liver. PLoS One. 2017; 12(3):e0173914. Gutiérrez-de-Juan V, López de Davalillo S, Fernández-Ramos D, Barbier-Torres L, Zubiete-Franco I, Fernández-Tussy P, Simon J, Lopitz-Otsoa F, de Las Heras J, Iruzubieta P, Arias-Loste MT, Villa E, Crespo J, Andrade R, Lucena MI, Varela-Rey M, Lu SC, Mato JM, Delgado TC, Martínez-Chantar ML. PMID: 28319158.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    40. Coffee Drinking and Alcoholic and Nonalcoholic Fatty Liver Diseases and Viral Hepatitis in the Multiethnic Cohort. Clin Gastroenterol Hepatol. 2017 08; 15(8):1305-1307. Setiawan VW, Porcel J, Wei P, Stram DO, Noureddin N, Lu SC, Le Marchand L, Noureddin M. PMID: 28300689.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells. Hepatology. 2017 04; 65(4):1249-1266. Fan W, Yang H, Liu T, Wang J, Li TW, Mavila N, Tang Y, Yang J, Peng H, Tu J, Annamalai A, Noureddin M, Krishnan A, Gores GJ, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 27981602.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    42. Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis. Gastroenterology. 2017 05; 152(6):1449-1461.e7. Alonso C, Fernández-Ramos D, Varela-Rey M, Martínez-Arranz I, Navasa N, Van Liempd SM, Lavín Trueba JL, Mayo R, Ilisso CP, de Juan VG, Iruarrizaga-Lejarreta M, delaCruz-Villar L, Mincholé I, Robinson A, Crespo J, Martín-Duce A, Romero-Gómez M, Sann H, Platon J, Van Eyk J, Aspichueta P, Noureddin M, Falcón-Pérez JM, Anguita J, Aransay AM, Martínez-Chantar ML, Lu SC, Mato JM. PMID: 28132890.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    43. Deregulated neddylation in liver fibrosis. Hepatology. 2017 02; 65(2):694-709. Zubiete-Franco I, Fernández-Tussy P, Barbier-Torres L, Simon J, Fernández-Ramos D, Lopitz-Otsoa F, Gutiérrez-de Juan V, de Davalillo SL, Duce AM, Iruzubieta P, Taibo D, Crespo J, Caballeria J, Villa E, Aurrekoetxea I, Aspichueta P, Varela-Rey M, Lu SC, Mato JM, Beraza N, Delgado TC, Martínez-Chantar ML. PMID: 28035772.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    44. Reply to High hepatocellular carcinoma risk among US-born Hispanics. Cancer. 2017 01 01; 123(2):358-359. Setiawan VW, Wei PC, Hernandez BY, Lu SC, Monroe KR, Marchand LL, Yuan JM. PMID: 27741358.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Prohibitin 1 Regulates the H19-Igf2 Axis and Proliferation in Hepatocytes. J Biol Chem. 2016 Nov 11; 291(46):24148-24159. Ramani K, Mavila N, Ko KS, Mato JM, Lu SC. PMID: 27687727.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort. Hepatology. 2016 12; 64(6):1969-1977. Setiawan VW, Stram DO, Porcel J, Lu SC, Le Marchand L, Noureddin M. PMID: 27301913.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    47. Deregulated methionine adenosyltransferase a1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡). Hepatology. 2016 08; 64(2):439-55. Yang H, Liu T, Wang J, Li TW, Fan W, Peng H, Krishnan A, Gores GJ, Mato JM, Lu SC. PMID: 26969892.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    48. MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease. Free Radic Biol Med. 2016 11; 100:66-72. Lu SC, Mato JM, Espinosa-Diez C, Lamas S. PMID: 27033954.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    49. Disparity in liver cancer incidence and chronic liver disease mortality by nativity in Hispanics: The Multiethnic Cohort. Cancer. 2016 05 01; 122(9):1444-52. Setiawan VW, Wei PC, Hernandez BY, Lu SC, Monroe KR, Le Marchand L, Yuan JM. PMID: 26916271.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    50. Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2104-9. Murray B, Antonyuk SV, Marina A, Lu SC, Mato JM, Hasnain SS, Rojas AL. PMID: 26858410.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    51. Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis. Hepatology. 2016 Jan; 63(1):17-9. Mato JM, Lu SC. PMID: 26335943.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. Methionine adenosyltransferase a2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells. Oncotarget. 2015 Nov 10; 6(35):37706-23. Tomasi ML, Ryoo M, Ramani K, Tomasi I, Giordano P, Mato JM, Lu SC. PMID: 26416353.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    53. Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2016 Feb; 14(2):309-16. Setiawan VW, Lim U, Lipworth L, Lu SC, Shepherd J, Ernst T, Wilkens LR, Henderson BE, Le Marchand L. PMID: 26404865.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    54. Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis. J Hepatol. 2016 Feb; 64(2):409-418. Zubiete-Franco I, García-Rodríguez JL, Martínez-Uña M, Martínez-Lopez N, Woodhoo A, Juan VG, Beraza N, Lage-Medina S, Andrade F, Fernandez ML, Aldámiz-Echevarría L, Fernández-Ramos D, Falcon-Perez JM, Lopitz-Otsoa F, Fernandez-Tussy P, Barbier-Torres L, Luka Z, Wagner C, García-Monzón C, Lu SC, Aspichueta P, Mato JM, Martínez-Chantar ML, Varela-Rey M. PMID: 26394163.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    55. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct; 62(4):1237-48. Barbier-Torres L, Beraza N, Fernández-Tussy P, Lopitz-Otsoa F, Fernández-Ramos D, Zubiete-Franco I, Varela-Rey M, Delgado TC, Gutiérrez V, Anguita J, Pares A, Banales JM, Villa E, Caballería J, Alvarez L, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 26109312.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    56. Nonalcoholic fatty liver disease: update on pathogenesis, diagnosis, treatment and the role of S-adenosylmethionine. Exp Biol Med (Maywood). 2015 Jun; 240(6):809-20. Noureddin M, Mato JM, Lu SC. PMID: 25873078.
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    57. Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells. Am J Pathol. 2015 Apr; 185(4):1135-44. Peng H, Li TW, Yang H, Moyer MP, Mato JM, Lu SC. PMID: 25794709.
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    58. Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer. Oncotarget. 2015 Feb 10; 6(4):2509-23. Barbier-Torres L, Delgado TC, García-Rodríguez JL, Zubiete-Franco I, Fernández-Ramos D, Buqué X, Cano A, Gutiérrez-de Juan V, Fernández-Domínguez I, Lopitz-Otsoa F, Fernández-Tussy P, Boix L, Bruix J, Villa E, Castro A, Lu SC, Aspichueta P, Xirodimas D, Varela-Rey M, Mato JM, Beraza N, Martínez-Chantar ML. PMID: 25650664.
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    59. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. Lab Invest. 2015 Feb; 95(2):223-36. Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, Barbier-Torres L, Lahoz A, Parés A, Luka Z, Wagner C, Lu SC, Mato JM, Martínez-Chantar ML, Beraza N. PMID: 25531568.
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    60. S-Adenosylmethionine and methylthioadenosine inhibit ß-catenin signaling by multiple mechanisms in liver and colon cancer. Mol Pharmacol. 2015 Jan; 87(1):77-86. Li TW, Peng H, Yang H, Kurniawidjaja S, Panthaki P, Zheng Y, Mato JM, Lu SC. PMID: 25338671.
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    61. Diabetes and racial/ethnic differences in hepatocellular carcinoma risk: the multiethnic cohort. J Natl Cancer Inst. 2014 Dec; 106(12). Setiawan VW, Hernandez BY, Lu SC, Stram DO, Wilkens LR, Le Marchand L, Henderson BE. PMID: 25326644.
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    62. S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease. J Hepatol. 2015 Mar; 62(3):673-81. Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P. PMID: 25457203.
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    63. Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice. Antioxid Redox Signal. 2015 Jan 20; 22(3):259-74. Yang H, Li TW, Zhou Y, Peng H, Liu T, Zandi E, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 25226451.
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    64. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology. 2015 Jan; 148(1):118-25; quiz e15. Setiawan VW, Wilkens LR, Lu SC, Hernandez BY, Le Marchand L, Henderson BE. PMID: 25305507.
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    65. Systems biology for hepatologists. Hepatology. 2014 Aug; 60(2):736-43. Mato JM, Martínez-Chantar ML, Lu SC. PMID: 24449428.
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    66. Structure and function study of the complex that synthesizes S-adenosylmethionine. IUCrJ. 2014 Jul 01; 1(Pt 4):240-9. Murray B, Antonyuk SV, Marina A, Van Liempd SM, Lu SC, Mato JM, Hasnain SS, Rojas AL. PMID: 25075345.
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    68. Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance. Hippocampus. 2014 Jul; 24(7):840-52. Carrasco M, Rabaneda LG, Murillo-Carretero M, Ortega-Martínez S, Martínez-Chantar ML, Woodhoo A, Luka Z, Wagner C, Lu SC, Mato JM, Micó JA, Castro C. PMID: 24687756.
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    69. S-adenosylmethionine levels regulate the schwann cell DNA methylome. Neuron. 2014 Mar 05; 81(5):1024-1039. Varela-Rey M, Iruarrizaga-Lejarreta M, Lozano JJ, Aransay AM, Fernandez AF, Lavin JL, Mósen-Ansorena D, Berdasco M, Turmaine M, Luka Z, Wagner C, Lu SC, Esteller M, Mirsky R, Jessen KR, Fraga MF, Martínez-Chantar ML, Mato JM, Woodhoo A. PMID: 24607226.
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    70. Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice. Free Radic Biol Med. 2014 Mar; 68:148-58. Tomasi ML, Ryoo M, Yang H, Iglesias Ara A, Ko KS, Lu SC. PMID: 24296246.
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    71. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis. Hepatology. 2013 Oct; 58(4):1296-305. Martínez-Uña M, Varela-Rey M, Cano A, Fernández-Ares L, Beraza N, Aurrekoetxea I, Martínez-Arranz I, García-Rodríguez JL, Buqué X, Mestre D, Luka Z, Wagner C, Alonso C, Finnell RH, Lu SC, Martínez-Chantar ML, Aspichueta P, Mato JM. PMID: 23505042.
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    72. Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. J Biol Chem. 2013 Aug 09; 288(32):23161-70. Yang H, Zheng Y, Li TW, Peng H, Fernandez-Ramos D, Martínez-Chantar ML, Rojas AL, Mato JM, Lu SC. PMID: 23814050.
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    73. MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. Hepatology. 2013 Jun; 57(6):2299-313. Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC. PMID: 23325601.
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    74. Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. Exp Cell Res. 2013 Jul 15; 319(12):1902-1911. Tomasi ML, Ryoo M, Skay A, Tomasi I, Giordano P, Mato JM, Lu SC. PMID: 23588207.
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    75. S-adenosylmethionine metabolism and liver disease. Ann Hepatol. 2013 Mar-Apr; 12(2):183-9. Mato JM, Martínez-Chantar ML, Lu SC. PMID: 23396728.
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    76. Alcohol, DNA methylation, and cancer. Alcohol Res. 2013; 35(1):25-35. Varela-Rey M, Woodhoo A, Martinez-Chantar ML, Mato JM, Lu SC. PMID: 24313162.
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    77. MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. J Clin Invest. 2013 Jan; 123(1):285-98. Yang H, Cho ME, Li TW, Peng H, Ko KS, Mato JM, Lu SC. PMID: 23241961.
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    78. Human antigen R contributes to hepatic stellate cell activation and liver fibrosis. Hepatology. 2012 Nov; 56(5):1870-82. Woodhoo A, Iruarrizaga-Lejarreta M, Beraza N, García-Rodríguez JL, Embade N, Fernández-Ramos D, Martínez-López N, Gutiérrez-De Juan V, Arteta B, Caballeria J, Lu SC, Mato JM, Varela-Rey M, Martínez-Chantar ML. PMID: 22576182.
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    79. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct; 92(4):1515-42. Lu SC, Mato JM. PMID: 23073625.
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    80. Glutathione synthesis. Biochim Biophys Acta. 2013 May; 1830(5):3143-53. Lu SC. PMID: 22995213.
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    81. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J Biol Chem. 2012 Oct 19; 287(43):36341-55. Ramani K, Tomasi ML, Yang H, Ko K, Lu SC. PMID: 22942279.
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    82. S-adenosyl methionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers. Hepatology. 2012 Sep; 56(3):982-93. Tomasi ML, Tomasi I, Ramani K, Pascale RM, Xu J, Giordano P, Mato JM, Lu SC. PMID: 22407595.
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    83. Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase. Hepatology. 2012 Aug; 56(2):747-59. Gomez-Santos L, Luka Z, Wagner C, Fernandez-Alvarez S, Lu SC, Mato JM, Martinez-Chantar ML, Beraza N. PMID: 22392635.
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    84. Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. Gastroenterology. 2012 Sep; 143(3):787-798.e13. Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 22687285.
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    85. The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development. J Neurosci. 2012 Apr 04; 32(14):4944-58. Iruarrizaga-Lejarreta M, Varela-Rey M, Lozano JJ, Fernández-Ramos D, Rodríguez-Ezpeleta N, Embade N, Lu SC, van der Kraan PM, Blaney Davidson EN, Gorospe M, Mirsky R, Jessen KR, Aransay AM, Mato JM, Martínez-Chantar ML, Woodhoo A. PMID: 22492050.
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    86. Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation. J Cell Physiol. 2012 Apr; 227(4):1583-91. Tomasi ML, Li TW, Li M, Mato JM, Lu SC. PMID: 21678410.
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    87. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology. 2012 Apr; 55(4):1237-48. Embade N, Fernández-Ramos D, Varela-Rey M, Beraza N, Sini M, Gutiérrez de Juan V, Woodhoo A, Martínez-López N, Rodríguez-Iruretagoyena B, Bustamante FJ, de la Hoz AB, Carracedo A, Xirodimas DP, Rodríguez MS, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 22095636.
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    88. Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III: Characterization of DDX3X as a target of S-adenosylmethionine. J Proteomics. 2012 Jun 06; 75(10):2855-68. Schröder PC, Fernández-Irigoyen J, Bigaud E, Serna A, Renández-Alcoceba R, Lu SC, Mato JM, Prieto J, Corrales FJ. PMID: 22270009.
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    89. Effects of S-adenosylmethionine and methylthioadenosine on inflammation-induced colon cancer in mice. Carcinogenesis. 2012 Feb; 33(2):427-35. Li TW, Yang H, Peng H, Xia M, Mato JM, Lu SC. PMID: 22159228.
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    90. Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. Hepatology. 2011 Dec; 54(6):1975-86. Cano A, Buqué X, Martínez-Uña M, Aurrekoetxea I, Menor A, García-Rodríguez JL, Lu SC, Martínez-Chantar ML, Mato JM, Ochoa B, Aspichueta P. PMID: 21837751.
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    91. Where are we in the search for noninvasive nonalcoholic steatohepatitis biomarkers? Hepatology. 2011 Oct; 54(4):1115-7. Mato JM, Lu SC. PMID: 21898494.
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    92. Serum UPLC-MS/MS metabolic profiling in an experimental model for acute-liver injury reveals potential biomarkers for hepatotoxicity. Metabolomics. 2012; 8(6):997-1011. Gonzalez E, van Liempd S, Conde-Vancells J, Gutierrez-de Juan V, Perez-Cormenzana M, Mayo R, Berisa A, Alonso C, Marquez CA, Barr J, Lu SC, Mato JM, Falcon-Perez JM. PMID: 23139648.
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    95. Role of methionine adenosyltransferase genes in hepatocarcinogenesis. Cancers (Basel). 2011 Mar 24; 3(2):1480-97. Ramani K, Mato JM, Lu SC. PMID: 24212770.
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    97. The hepatocarcinogenic effect of methionine and choline deficient diets: an adaptation to the Warburg effect? Alcohol Clin Exp Res. 2011 May; 35(5):811-4. Mato JM, Lu SC. PMID: 21284672.
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    98. S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes. Eur J Cell Biol. 2011 Apr; 90(4):312-22. Yamaji S, Droggiti A, Lu SC, Martinez-Chantar ML, Warner A, Varela-Rey M. PMID: 21093098.
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    99. Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis. Hepatology. 2010 Nov; 52(5):1621-31. Martínez-López N, Varela-Rey M, Fernández-Ramos D, Woodhoo A, Vázquez-Chantada M, Embade N, Espinosa-Hevia L, Bustamante FJ, Parada LA, Rodriguez MS, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 20815019.
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    100. Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec; 52(6):2096-108. Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 20890892.
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    101. Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J Proteome Res. 2010 Sep 03; 9(9):4501-12. Barr J, Vázquez-Chantada M, Alonso C, Pérez-Cormenzana M, Mayo R, Galán A, Caballería J, Martín-Duce A, Tran A, Wagner C, Luka Z, Lu SC, Castro A, Le Marchand-Brustel Y, Martínez-Chantar ML, Veyrie N, Clément K, Tordjman J, Gual P, Mato JM. PMID: 20684516.
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    102. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53. Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. PMID: 20564331.
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    103. Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide. Hepatology. 2010 Jul; 52(1):105-14. Varela-Rey M, Martínez-López N, Fernández-Ramos D, Embade N, Calvisi DF, Woodhoo A, Rodríguez J, Fraga MF, Julve J, Rodríguez-Millán E, Frades I, Torres L, Luka Z, Wagner C, Esteller M, Lu SC, Martínez-Chantar ML, Mato JM. PMID: 20578266.
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    104. S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes. Hepatology. 2010 Jun; 51(6):2152-61. Tomasi ML, Ramani K, Lopitz-Otsoa F, Rodríguez MS, Li TW, Ko K, Yang H, Bardag-Gorce F, Iglesias-Ara A, Feo F, Pascale MR, Mato JM, Lu SC. PMID: 20196119.
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    105. Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol. 2010 May; 6(5):543-54. Conde-Vancells J, Gonzalez E, Lu SC, Mato JM, Falcon-Perez JM. PMID: 20192903.
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    108. Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice. Hepatology. 2010 Apr; 51(4):1291-301. Yang H, Ko K, Xia M, Li TW, Oh P, Li J, Lu SC. PMID: 20146260.
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    110. Where are we in the chemoprevention of hepatocellular carcinoma? Hepatology. 2010 Mar; 51(3):734-6. Lu SC. PMID: 20198627.
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    114. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology. 2010 May; 138(5):1943-53. Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 20102719.
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    121. CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology. 2009 Apr; 49(4):1277-86. Ding W, Mouzaki M, You H, Laird JC, Mato J, Lu SC, Rountree CB. PMID: 19115422.
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    122. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. Hepatology. 2009 Mar; 49(3):860-70. Yang H, Li TW, Ko KS, Xia M, Lu SC. PMID: 19086036.
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    123. Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation. Hepatology. 2009 Feb; 49(2):608-17. Vázquez-Chantada M, Ariz U, Varela-Rey M, Embade N, Martínez-Lopez N, Fernández-Ramos D, Gómez-Santos L, Lamas S, Lu SC, Martínez-Chantar ML, Mato JM. PMID: 19177591.
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    124. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res. 2008 Dec; 7(12):5157-66. Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM. PMID: 19367702.
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    125. Betaine prevents Mallory-Denk body formation in drug-primed mice by epigenetic mechanisms. Exp Mol Pathol. 2009 Apr; 86(2):77-86. Oliva J, Bardag-Gorce F, Li J, French BA, Nguyen SK, Lu SC, French SW. PMID: 19073172.
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    126. Non-alcoholic steatohepatitis and animal models: understanding the human disease. Int J Biochem Cell Biol. 2009 May; 41(5):969-76. Varela-Rey M, Embade N, Ariz U, Lu SC, Mato JM, Martínez-Chantar ML. PMID: 19027869.
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    127. Antioxidants in the treatment of chronic liver diseases: why is the efficacy evidence so weak in humans? Hepatology. 2008 Nov; 48(5):1359-61. Lu SC. PMID: 18697215.
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    128. Requirement of RIZ1 for cancer prevention by methyl-balanced diet. PLoS One. 2008; 3(10):e3390. Zhou W, Alonso S, Takai D, Lu SC, Yamamoto F, Perucho M, Huang S. PMID: 18852888.
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    129. S-adenosylmethionine and proliferation: new pathways, new targets. Biochem Soc Trans. 2008 Oct; 36(Pt 5):848-52. Martínez-López N, Varela-Rey M, Ariz U, Embade N, Vazquez-Chantada M, Fernandez-Ramos D, Gomez-Santos L, Lu SC, Mato JM, Martinez-Chantar ML. PMID: 18793149.
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    130. S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis. Gastroenterology. 2009 Mar; 136(3):1025-36. Tomasi ML, Iglesias-Ara A, Yang H, Ramani K, Feo F, Pascale MR, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 18983843.
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    131. Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab Invest. 2008 Oct; 88(10):1121-9. Ko K, Yang H, Noureddin M, Iglesia-Ara A, Xia M, Wagner C, Luka Z, Mato JM, Lu SC. PMID: 18695670.
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    132. Emerging role of epigenetics in the actions of alcohol. Alcohol Clin Exp Res. 2008 Sep; 32(9):1525-34. Shukla SD, Velazquez J, French SW, Lu SC, Ticku MK, Zakhari S. PMID: 18616668.
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    133. Regulation of glutathione synthesis. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):42-59. Lu SC. PMID: 18601945.
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    134. S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology. 2008 May; 47(5):1655-66. Ara AI, Xia M, Ramani K, Mato JM, Lu SC. PMID: 18393372.
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    135. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008 Apr; 47(4):1288-97. Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. PMID: 18167064.
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    136. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 2008 Apr; 47(4):1191-9. Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevila A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM. PMID: 18318442.
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    137. S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S73-7. Lu SC, Mato JM. PMID: 18336669.
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    138. Alcohol, cofactors and the genetics of hepatocellular carcinoma. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S92-7. Yu MC, Yuan JM, Lu SC. PMID: 18336674.
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    139. Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta. Hepatology. 2008 Feb; 47(2):521-31. Ramani K, Yang H, Xia M, Ara AI, Mato JM, Lu SC. PMID: 18041713.
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    140. Epigallocatechin-3-gallate inhibits growth of activated hepatic stellate cells by enhancing the capacity of glutathione synthesis. Mol Pharmacol. 2008 May; 73(5):1465-73. Fu Y, Zheng S, Lu SC, Chen A. PMID: 18230716.
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    141. Methionine metabolism and liver disease. Annu Rev Nutr. 2008; 28:273-93. Mato JM, Martínez-Chantar ML, Lu SC. PMID: 18331185.
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    142. Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. Gastroenterology. 2008 Jan; 134(1):281-91. Yang H, Ara AI, Magilnick N, Xia M, Ramani K, Chen H, Lee TD, Mato JM, Lu SC. PMID: 18045590.
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    143. Effects of hepatocyte growth factor on glutathione synthesis, growth, and apoptosis is cell density-dependent. Exp Cell Res. 2008 Jan 15; 314(2):398-412. Yang H, Magilnick N, Xia M, Lu SC. PMID: 17950727.
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    144. Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. Hepatology. 2007 Sep; 46(3):749-58. Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, Yu MC. PMID: 17659576.
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    145. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr. 2007 Jul; 86(1):14-24. Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, Kharbanda KK, Liu QY, Lu SC, McClain CJ, Swanson C, Zakhari S. PMID: 17616758.
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    146. Role of S-adenosyl-L-methionine in liver health and injury. Hepatology. 2007 May; 45(5):1306-12. Mato JM, Lu SC. PMID: 17464973.
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    147. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul; 133(1):207-18. Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC. PMID: 17631143.
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    148. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cell Physiol. 2007 Mar; 210(3):766-73. Yang H, Magilnick N, Noureddin M, Mato JM, Lu SC. PMID: 17154373.
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    149. Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine. Biochem J. 2007 Jan 01; 401(1):87-96. Ou X, Yang H, Ramani K, Ara AI, Chen H, Mato JM, Lu SC. PMID: 16953798.
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    150. Identification of a gene-pathway associated with non-alcoholic steatohepatitis. J Hepatol. 2007 Apr; 46(4):708-18. Rubio A, Guruceaga E, Vázquez-Chantada M, Sandoval J, Martínez-Cruz LA, Segura V, Sevilla JL, Podhorski A, Corrales FJ, Torres L, Rodríguez M, Aillet F, Ariz U, Arrieta FM, Caballería J, Martín-Duce A, Lu SC, Martínez-Chantar ML, Mato JM. PMID: 17275126.
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    151. Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S61-4. Lu SC, Martínez-Chantar ML, Mato JM. PMID: 16958675.
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    152. S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Gastroenterology. 2006 Jul; 131(1):223-32. Martínez-Chantar ML, Vázquez-Chantada M, Garnacho M, Latasa MU, Varela-Rey M, Dotor J, Santamaria M, Martínez-Cruz LA, Parada LA, Lu SC, Mato JM. PMID: 16831604.
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    153. S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6489-94. Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R. PMID: 16614071.
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    154. Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases. J Proteome Res. 2006 Apr; 5(4):944-53. Santamaría E, Muñoz J, Fernandez-Irigoyen J, Sesma L, Mora MI, Berasain C, Lu SC, Mato JM, Prieto J, Avila MA, Corrales FJ. PMID: 16602702.
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    155. Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis. Proteomics. 2005 Dec; 5(18):4964-72. Fernández-Irigoyen J, Santamaría E, Sesma L, Muñoz J, Riezu JI, Caballería J, Lu SC, Prieto J, Mato JM, Avila MA, Corrales FJ. PMID: 16252306.
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    156. Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. Biochem J. 2005 Oct 15; 391(Pt 2):399-408. Yang H, Magilnick N, Ou X, Lu SC. PMID: 16011481.
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    157. Cloning and characterization of the human glutathione synthetase 5'-flanking region. Biochem J. 2005 Sep 01; 390(Pt 2):521-8. Lee TD, Yang H, Whang J, Lu SC. PMID: 15890065.
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    158. Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol Cell Biol. 2005 Jul; 25(14):5933-46. Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY, Lu SC. PMID: 15988009.
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    159. Homocysteine, the bad thiol. Hepatology. 2005 May; 41(5):976-9. Mato JM, Lu SC. PMID: 15841447.
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    160. Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Alcohol. 2005 Apr; 35(3):227-34. Lu SC, Mato JM. PMID: 16054984.
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    161. Keratin mutation primes mouse liver to oxidative injury. Hepatology. 2005 Mar; 41(3):517-25. Zhou Q, Ji X, Chen L, Greenberg HB, Lu SC, Omary MB. PMID: 15726665.
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    162. WITHDRAWN: Silencing of human methionine adenosyltransferase 1A expression by methylation of the coding region. J Biol Chem. 2004 Dec 08. Li M, Ou X, Lee TD, Zeng Y, Mato JM, Lu SC. PMID: 15590672.
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    163. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov; 36(11):2125-30. Avila MA, García-Trevijano ER, Lu SC, Corrales FJ, Mato JM. PMID: 15313459.
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    164. 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis. J Biol Chem. 2004 Oct 29; 279(44):46263-70. Lim SY, Jang JH, Na HK, Lu SC, Rahman I, Surh YJ. PMID: 15319433.
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    165. S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S). Hepatology. 2004 Jul; 40(1):221-31. Yang H, Sadda MR, Li M, Zeng Y, Chen L, Bae W, Ou X, Runnegar MT, Mato JM, Lu SC. PMID: 15239106.
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    166. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. PMID: 15064230.
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    167. 5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes. Hepatology. 2004 Apr; 39(4):1088-98. Hevia H, Varela-Rey M, Corrales FJ, Berasain C, Martínez-Chantar ML, Latasa MU, Lu SC, Mato JM, García-Trevijano ER, Avila MA. PMID: 15057913.
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    168. Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A. FASEB J. 2004 May; 18(7):914-6. Chen L, Zeng Y, Yang H, Lee TD, French SW, Corrales FJ, García-Trevijano ER, Avila MA, Mato JM, Lu SC. PMID: 15033934.
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    169. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar; 65(3):550-7. Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. PMID: 14978233.
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    170. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res. 2004 Jan; 28(1):173-81. Lee TD, Sadda MR, Mendler MH, Bottiglieri T, Kanel G, Mato JM, Lu SC. PMID: 14745316.
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    171. RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity. Exp Mol Pathol. 2003 Dec; 75(3):194-200. Dai T, Wu Y, Leng AS, Ao Y, Robel RC, Lu SC, French SW, Wan YJ. PMID: 14611810.
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    172. Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. J Biol Chem. 2003 Dec 19; 278(51):50887-96. Yang H, Sadda MR, Yu V, Zeng Y, Lee TD, Ou X, Chen L, Lu SC. PMID: 14530285.
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    173. L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. J Biol Chem. 2003 May 30; 278(22):19885-90. Martínez-Chantar ML, Latasa MU, Varela-Rey M, Lu SC, García-Trevijano ER, Mato JM, Avila MA. PMID: 12660248.
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    174. Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3065-70. Santamaria E, Avila MA, Latasa MU, Rubio A, Martin-Duce A, Lu SC, Mato JM, Corrales FJ. PMID: 12631701.
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    175. Role of S-adenosylmethionine in two experimental models of pancreatitis. FASEB J. 2003 Jan; 17(1):56-8. Lu SC, Gukovsky I, Lugea A, Reyes CN, Huang ZZ, Chen L, Mato JM, Bottiglieri T, Pandol SJ. PMID: 12424217.
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    176. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol. 2002 Jul; 27(3):155-62. Lu SC, Tsukamoto H, Mato JM. PMID: 12163143.
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    177. Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone. J Biol Chem. 2002 Sep 20; 277(38):35232-9. Yang H, Zeng Y, Lee TD, Yang Y, Ou X, Chen L, Haque M, Rippe R, Lu SC. PMID: 12093805.
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    178. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 2002 Aug; 16(10):1292-4. Martínez-Chantar ML, Corrales FJ, Martínez-Cruz LA, García-Trevijano ER, Huang ZZ, Chen L, Kanel G, Avila MA, Mato JM, Lu SC. PMID: 12060674.
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    179. S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells. Hepatology. 2002 Feb; 35(2):274-80. Ansorena E, García-Trevijano ER, Martínez-Chantar ML, Huang ZZ, Chen L, Mato JM, Iraburu M, Lu SC, Avila MA. PMID: 11826399.
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    180. S-Adenosylmethionine: a control switch that regulates liver function. FASEB J. 2002 Jan; 16(1):15-26. Mato JM, Corrales FJ, Lu SC, Avila MA. PMID: 11772932.
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