Mourad Tighiouart

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
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    1. A Phase I Study of Autologous Dendritic Cell Vaccine Pulsed with Allogeneic Stem-like Cell Line Lysate in Patients with Newly Diagnosed or Recurrent Glioblastoma. Clin Cancer Res. 2022 02 15; 28(4):689-696. Hu JL, Omofoye OA, Rudnick JD, Kim S, Tighiouart M, Phuphanich S, Wang H, Mazer M, Ganaway T, Chu RM, Patil CG, Black KL, Shiao SL, Wang R, Yu JS. PMID: 34862245.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsCTClinical Trials
    2. A nonparametric Bayesian method for dose finding in drug combinations cancer trials. Stat Med. 2022 03 15; 41(6):1059-1080. Razaee ZS, Cook-Wiens G, Tighiouart M. PMID: 35075652; PMCID: PMC8881404.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Visualizing adverse events in clinical trials using correspondence analysis with R-package visae. BMC Med Res Methodol. 2021 11 09; 21(1):244. Diniz MA, Gresham G, Kim S, Luu M, Henry NL, Tighiouart M, Yothers G, Ganz PA, Rogatko A. PMID: 34753452; PMCID: PMC8579548.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Plasma Glutamine as a Prognostic Biomarker in Localized Prostate Cancer: Comparison of Conventional Variables in Risk Stratification. Oncology (Williston Park). 2021 09 14; 35(9):528-535. Smith B, Kim S, Tighiouart M, Posadas E, Chung L, Figlin R, Bhowmick N, Gong J. PMID: 34524771.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Home-based virtual reality for chronic pain: protocol for an NIH-supported randomised-controlled trial. BMJ Open. 2021 06 15; 11(6):e050545. Birckhead B, Eberlein S, Alvarez G, Gale R, Dupuy T, Makaroff K, Fuller G, Liu X, Yu KS, Black JT, Ishimori M, Venuturupalli S, Tu J, Norris T, Tighiouart M, Ross L, McKelvey K, Vrahas M, Danovitch I, Spiegel B. PMID: 34130965; PMCID: PMC8207994.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    6. Nodal staging convergence for HPV- and HPV+ oropharyngeal carcinoma. Cancer. 2021 05 15; 127(10):1590-1597. Ho AS, Luu M, Kim S, Tighiouart M, Mita AC, Scher KS, Mallen-St Clair J, Walgama ES, Lin DC, Nguyen AT, Zumsteg ZS. PMID: 33595897.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD. J Clin Oncol. 2021 06 10; 39(17):1865-1877. Watkins B, Qayed M, McCracken C, Bratrude B, Betz K, Suessmuth Y, Yu A, Sinclair S, Furlan S, Bosinger S, Tkachev V, Rhodes J, Tumlin AG, Narayan A, Cribbin K, Gillespie S, Gooley TA, Pasquini MC, Hebert K, Kapoor U, Rogatko A, Tighiouart M, Kim S, Bresee C, Choi SW, Davis J, Duncan C, Giller R, Grimley M, Harris AC, Jacobsohn D, Lalefar N, Norkin M, Farhadfar N, Pulsipher MA, Shenoy S, Petrovic A, Schultz KR, Yanik GA, Waller EK, Levine JE, Ferrara JL, Blazar BR, Langston A, Horan JT, Kean LS. PMID: 33449816; PMCID: PMC8260909.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCTClinical Trials
    8. On the properties of the toxicity index and its statistical efficiency. Stat Med. 2021 03 15; 40(6):1535-1552. Razaee ZS, Amini AA, Diniz MA, Tighiouart M, Yothers G, Rogatko A. PMID: 33345351; PMCID: PMC7953898.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    9. Evaluating Treatment Tolerability in Cancer Clinical Trials Using the Toxicity Index. J Natl Cancer Inst. 2020 12 14; 112(12):1266-1274. Gresham G, Diniz MA, Razaee ZS, Luu M, Kim S, Hays RD, Piantadosi S, Tighiouart M, Yothers G, Ganz PA, Rogatko A. PMID: 32091598; PMCID: PMC7735773.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    10. Editor's Note: The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2020 09 15; 26(18):5052. Wang D, Müller S, Ruhul Amin ARM, Huang D, Su L, Hu Z, Rahman MA, Nannapaneni S, Koenig L, Chen Z, Tighiouart M, Shin DM, Chen ZG. PMID: 32934033.
      View in: PubMed   Mentions:    Fields:    
    11. Effect of Androgen Deprivation on Long-term Outcomes of Intermediate-Risk Prostate Cancer Stratified as Favorable or Unfavorable: A Secondary Analysis of the RTOG 9408 Randomized Clinical Trial. JAMA Netw Open. 2020 09 01; 3(9):e2015083. Zumsteg ZS, Spratt DE, Daskivich TJ, Tighiouart M, Luu M, Rodgers JP, Sandler HM. PMID: 32902647; PMCID: PMC7489808.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. A Bayesian Adaptive Design in Cancer Phase I Trials Using Dose Combinations with Ordinal Toxicity Grades. Stats (Basel). 2020 Sep; 3(3):221-238. Diniz MA, Kim S, Tighiouart M. PMID: 33073179; PMCID: PMC7561046.
      View in: PubMed   Mentions: 1  
    13. Multicenter Study on the Diagnostic Performance of Native-T1 Cardiac Magnetic Resonance of Chronic Myocardial Infarctions at 3T. Circ Cardiovasc Imaging. 2020 06; 13(6):e009894. Wang G, Lee SE, Yang Q, Sadras V, Patel S, Yang HJ, Sharif B, Kali A, Cokic I, Xie G, Tighiouart M, Collins J, Li D, Berman DS, Chang HJ, Dharmakumar R. PMID: 32507020; PMCID: PMC7363195.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance. Proc Natl Acad Sci U S A. 2020 04 14; 117(15):8515-8523. Haldar S, Mishra R, Billet S, Thiruvalluvan M, Placencio-Hickok VR, Madhav A, Duong F, Angara B, Agarwal P, Tighiouart M, Posadas EM, Bhowmick NA. PMID: 32238563; PMCID: PMC7165425.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    15. A Bayesian seamless phase I-II trial design with two stages for cancer clinical trials with drug combinations. Biom J. 2020 09; 62(5):1300-1314. Jiménez JL, Kim S, Tighiouart M. PMID: 32150296; PMCID: PMC7483235.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors. Pediatr Blood Cancer. 2020 04; 67(4):e28134. Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM. PMID: 31876107.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    17. Quantitative lymph node burden as a 'very-high-risk' factor identifying head and neck cancer patients benefiting from postoperative chemoradiation. Ann Oncol. 2019 10 01; 30(10):1669. Zumsteg ZS, Luu M, Kim S, Tighiouart M, Mita A, Scher KS, Lu DJ, Shiao SL, Mallen-St Clair J, Ho AS. PMID: 31168574; PMCID: PMC6857612.
      View in: PubMed   Mentions:    Fields:    
    18. Accurate needle-free assessment of myocardial oxygenation for ischemic heart disease in canines using magnetic resonance imaging. Sci Transl Med. 2019 05 29; 11(494). Yang HJ, Oksuz I, Dey D, Sykes J, Klein M, Butler J, Kovacs MS, Sobczyk O, Cokic I, Slomka PJ, Bi X, Li D, Tighiouart M, Tsaftaris SA, Prato FS, Fisher JA, Dharmakumar R. PMID: 31142677.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    19. Survival Impact of Adjuvant Therapy in Salivary Gland Cancers following Resection and Neck Dissection. Otolaryngol Head Neck Surg. 2019 06; 160(6):1048-1057. Aro K, Ho AS, Luu M, Kim S, Tighiouart M, Yoshida EJ, Mallen-St Clair J, Shiao SL, Leivo I, Zumsteg ZS. PMID: 30721113.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Comparison between continuous and discrete doses for model based designs in cancer dose finding. PLoS One. 2019; 14(1):e0210139. Diniz MA, Tighiouart M, Rogatko A. PMID: 30625194; PMCID: PMC6326565.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. A phase 1 study of veliparib, a PARP-1/2 inhibitor, with gemcitabine and radiotherapy in locally advanced pancreatic cancer. EBioMedicine. 2019 Feb; 40:375-381. Tuli R, Shiao SL, Nissen N, Tighiouart M, Kim S, Osipov A, Bryant M, Ristow L, Placencio-Hickok V, Hoffman D, Rokhsar S, Scher K, Klempner SJ, Noe P, Davis MJ, Wachsman A, Lo S, Jamil L, Sandler H, Piantadosi S, Hendifar A. PMID: 30635165; PMCID: PMC6412162.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCTClinical Trials
    22. Quantitative lymph node burden as a 'very-high-risk' factor identifying head and neck cancer patients benefiting from postoperative chemoradiation. Ann Oncol. 2019 01 01; 30(1):76-84. Zumsteg ZS, Luu M, Kim S, Tighiouart M, Mita A, Scher KS, Lu DJ, Shiao SL, Mallen-St Clair J, Ho AS. PMID: 30395159; PMCID: PMC6336000.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    23. A Bayesian Adaptive Design in Cancer Phase I Trials using Dose Combinations in the Presence of a Baseline Covariate. J Probab Stat. 2018; 2018. Diniz MA, Kim S, Tighiouart M. PMID: 30906326; PMCID: PMC6428433.
      View in: PubMed   Mentions: 1  
    24. Association of Quantitative Metastatic Lymph Node Burden With Survival in Hypopharyngeal and Laryngeal Cancer. JAMA Oncol. 2018 07 01; 4(7):985-989. Ho AS, Kim S, Tighiouart M, Gudino C, Mita A, Scher KS, Laury A, Prasad R, Shiao SL, Ali N, Patio C, Mallen-St Clair J, Van Eyk JE, Zumsteg ZS. PMID: 29192305; PMCID: PMC6584272.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    25. Two-stage design for phase I-II cancer clinical trials using continuous dose combinations of cytotoxic agents. J R Stat Soc Ser C Appl Stat. 2019 Jan; 68(1):235-250. Tighiouart M. PMID: 30745708; PMCID: PMC6368405.
      View in: PubMed   Mentions: 4  
    26. Cancer phase I trial design using drug combinations when a fraction of dose limiting toxicities is attributable to one or more agents. Biom J. 2019 03; 61(2):319-332. Jimenez JL, Tighiouart M, Gasparini M. PMID: 29808507; PMCID: PMC6261712.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Development of a novel salivary gland cancer lymph node staging system. Cancer. 2018 08 01; 124(15):3171-3180. Aro K, Ho AS, Luu M, Kim S, Tighiouart M, Clair JM, Yoshida EJ, Shiao SL, Leivo I, Zumsteg ZS. PMID: 29742277; PMCID: PMC6097925.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    28. Quantitative survival impact of composite treatment delays in head and neck cancer. Cancer. 2018 08 01; 124(15):3154-3162. Ho AS, Kim S, Tighiouart M, Mita A, Scher KS, Epstein JB, Laury A, Prasad R, Ali N, Patio C, Clair JM, Zumsteg ZS. PMID: 29742280; PMCID: PMC6097917.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    29. Postoperative chemoradiotherapy in patients with head and neck cancer aged 70 or older with positive margins or extranodal extension and the influence of nodal classification. Head Neck. 2018 06; 40(6):1228-1236. Yoshida EJ, Luu M, David JM, Kim S, Mita A, Scher K, Shiao SL, Tighiouart M, Ho AS, Zumsteg ZS. PMID: 29417700.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    30. Dose Finding for Drug Combination in Early Cancer Phase I Trials using Conditional Continual Reassessment Method. J Biom Biostat. 2017; 8(6). Diniz MA, Tighiouart M. PMID: 29552377; PMCID: PMC5851015.
      View in: PubMed   Mentions: 3  
    31. A Bayesian adaptive design for cancer phase I trials using a flexible range of doses. J Biopharm Stat. 2018; 28(3):562-574. Tighiouart M, Cook-Wiens G, Rogatko A. PMID: 28858566; PMCID: PMC5832533.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Facility Volume and Survival in Nasopharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2018 02 01; 100(2):408-417. Yoshida EJ, Luu M, David JM, Kim S, Mita A, Scher K, Shiao SL, Tighiouart M, Lee NY, Ho AS, Zumsteg ZS. PMID: 29100787.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    33. Metastatic Lymph Node Burden and Survival in Oral Cavity Cancer. J Clin Oncol. 2017 Nov 01; 35(31):3601-3609. Ho AS, Kim S, Tighiouart M, Gudino C, Mita A, Scher KS, Laury A, Prasad R, Shiao SL, Van Eyk JE, Zumsteg ZS. PMID: 28880746; PMCID: PMC5791830.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    34. Combined high-intensity local treatment and systemic therapy in metastatic head and neck squamous cell carcinoma: An analysis of the National Cancer Data Base. Cancer. 2017 Dec 01; 123(23):4583-4593. Zumsteg ZS, Luu M, Yoshida EJ, Kim S, Tighiouart M, David JM, Shiao SL, Mita AC, Scher KS, Sherman EJ, Lee NY, Ho AS. PMID: 28817183; PMCID: PMC5745815.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. Treatment at high-volume facilities and academic centers is independently associated with improved survival in patients with locally advanced head and neck cancer. Cancer. 2017 Oct 15; 123(20):3933-3942. David JM, Ho AS, Luu M, Yoshida EJ, Kim S, Mita AC, Scher KS, Shiao SL, Tighiouart M, Zumsteg ZS. PMID: 28640546.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    36. Arterial CO2 as a Potent Coronary Vasodilator: A Preclinical PET/MR Validation Study with Implications for Cardiac Stress Testing. J Nucl Med. 2017 06; 58(6):953-960. Yang HJ, Dey D, Sykes J, Klein M, Butler J, Kovacs MS, Sobczyk O, Sharif B, Bi X, Kali A, Cokic I, Tang R, Yumul R, Conte AH, Tsaftaris SA, Tighiouart M, Li D, Slomka PJ, Berman DS, Prato FS, Fisher JA, Dharmakumar R. PMID: 28254864; PMCID: PMC5450368.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    37. Pitfalls and Rewards for Implementing Ocular Motor Testing in Acute Vestibular Syndrome: A Pilot Project. Neurologist. 2017 Mar; 22(2):44-47. Dumitrascu OM, Torbati S, Tighiouart M, Newman-Toker DE, Song SS. PMID: 28248913; PMCID: PMC5334787.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    38. Impact of concomitant chemoradiation on survival for patients with T1-2N1 head and neck cancer. Cancer. 2017 05 01; 123(9):1555-1565. Zumsteg ZS, Kim S, David JM, Yoshida EJ, Tighiouart M, Shiao SL, Scher K, Mita A, Sherman EJ, Lee NY, Ho AS. PMID: 28001302.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. A Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical Trials. Am J Biostat. 2016; 6(1):1-11. Tighiouart M, Li Q, Piantadosi S, Rogatko A. PMID: 28706582; PMCID: PMC5505662.
      View in: PubMed   Mentions: 6  
    40. A Bayesian adaptive design for estimating the maximum tolerated dose curve using drug combinations in cancer phase I clinical trials. Stat Med. 2017 01 30; 36(2):280-290. Tighiouart M, Li Q, Rogatko A. PMID: 27060889; PMCID: PMC5055414.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    41. Impact of margin status and lymphadenectomy on clinical outcomes in resected pancreatic adenocarcinoma: implications for adjuvant radiotherapy. J Gastrointest Oncol. 2016 Apr; 7(2):239-47. Osipov A, Naziri J, Hendifar A, Dhall D, Rutgers JK, Chopra S, Li Q, Tighiouart M, Annamalai A, Nissen NN, Tuli R. PMID: 27034792; PMCID: PMC4783734.
      View in: PubMed   Mentions: 4  
    42. Native T1 Mapping by 3-T CMR Imaging for Characterization of Chronic Myocardial Infarctions. JACC Cardiovasc Imaging. 2015 Sep; 8(9):1019-1030. Kali A, Choi EY, Sharif B, Kim YJ, Bi X, Spottiswoode B, Cokic I, Yang HJ, Tighiouart M, Conte AH, Li D, Berman DS, Choi BW, Chang HJ, Dharmakumar R. PMID: 26298071.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    43. Iron-Sensitive Cardiac Magnetic Resonance Imaging for Prediction of Ventricular Arrhythmia Risk in Patients With Chronic Myocardial Infarction: Early Evidence. Circ Cardiovasc Imaging. 2015 Aug; 8(8). Cokic I, Kali A, Yang HJ, Yee R, Tang R, Tighiouart M, Wang X, Jackman WS, Chugh SS, White JA, Dharmakumar R. PMID: 26259581; PMCID: PMC4779060.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    44. Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding. Entropy (Basel). 2015 Aug; 17(8):5288-5303. Rogatko A, Cook-Wiens G, Tighiouart M, Piantadosi S. PMID: 27156869; PMCID: PMC4859761.
      View in: PubMed   Mentions: 3  
    45. A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clin Cancer Res. 2015 Apr 15; 21(8):1859-68. Owonikoko TK, Ramalingam SS, Miller DL, Force SD, Sica GL, Mendel J, Chen Z, Rogatko A, Tighiouart M, Harvey RD, Kim S, Saba NF, Pickens A, Behera M, Fu RW, Rossi MR, Auffermann WF, Torres WE, Bechara R, Deng X, Sun SY, Fu H, Gal AA, Khuri FR. PMID: 25673697; PMCID: PMC4401630.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    46. Analysis of the bypass angioplasty revascularization investigation trial using a multistate model of clinical outcomes. Am J Cardiol. 2015 Apr 15; 115(8):1073-9. Zhang X, Li Q, Rogatko A, Tighiouart M, Hardison RM, Brooks MM, Kelsey SF, Kaul S, Bairey Merz CN. PMID: 25724784; PMCID: PMC4380580.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    47. Cardiac steatosis and left ventricular dysfunction in HIV-infected patients treated with highly active antiretroviral therapy. JACC Cardiovasc Imaging. 2014 Nov; 7(11):1175-7. Nelson MD, Szczepaniak LS, LaBounty TM, Szczepaniak E, Li D, Tighiouart M, Li Q, Dharmakumar R, Sannes G, Fan Z, Yumul R, Hardy WD, Hernandez Conte A. PMID: 25459601; PMCID: PMC5689079.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    48. Increasing percutaneous coronary interventions for ST-segment elevation myocardial infarction in the United States: progress and opportunity. JACC Cardiovasc Interv. 2015 Jan; 8(1 Pt B):139-146. Shah RU, Henry TD, Rutten-Ramos S, Garberich RF, Tighiouart M, Bairey Merz CN. PMID: 25616918.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    49. Dose finding with drug combinations in cancer phase I clinical trials using conditional escalation with overdose control. Stat Med. 2014 Sep 28; 33(22):3815-29. Tighiouart M, Piantadosi S, Rogatko A. PMID: 24825779; PMCID: PMC4156522.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    50. Escalation with overdose control using time to toxicity for cancer phase I clinical trials. PLoS One. 2014; 9(3):e93070. Tighiouart M, Liu Y, Rogatko A. PMID: 24663812; PMCID: PMC3963973.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    51. Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer. PLoS One. 2014; 9(2):e88967. Shao C, Liao CP, Hu P, Chu CY, Zhang L, Bui MH, Ng CS, Josephson DY, Knudsen B, Tighiouart M, Kim HL, Zhau HE, Chung LW, Wang R, Posadas EM. PMID: 24551200; PMCID: PMC3925210.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    52. A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer. Clin Cancer Res. 2014 Feb 01; 20(3):711-23. Cheon DJ, Tong Y, Sim MS, Dering J, Berel D, Cui X, Lester J, Beach JA, Tighiouart M, Walts AE, Karlan BY, Orsulic S. PMID: 24218511; PMCID: PMC3946428.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    53. The Integrated Web Portal for Escalation with Overdose Control (EWOC). Open Med Inform J. 2013; 7:18-23. Wang H, Tighiouart M, Huang SC, Berel D, Cook-Wiens G, Bresee C, Li Q, Rogatko A. PMID: 23847696; PMCID: PMC3706802.
      View in: PubMed   Mentions: 1  
    54. Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma. Cancer Biol Ther. 2013 Apr; 14(4):365-9. Fan S, Müller S, Chen ZG, Pan L, Tighiouart M, Shin DM, Khuri FR, Sun SY. PMID: 23358467; PMCID: PMC3667877.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    55. A phase 1 Bayesian dose selection study of bortezomib and sunitinib in patients with refractory solid tumor malignancies. Br J Cancer. 2013 Mar 05; 108(4):762-5. Harvey RD, Owonikoko TK, Lewis CM, Akintayo A, Chen Z, Tighiouart M, Ramalingam SS, Fanucchi MP, Nadella P, Rogatko A, Shin DM, El-Rayes B, Khuri FR, Kauh JS. PMID: 23322195; PMCID: PMC3590658.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    56. The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma. Clin Cancer Res. 2012 Sep 01; 18(17):4589-99. Wang D, Müller S, Amin AR, Huang D, Su L, Hu Z, Rahman MA, Nannapaneni S, Koenig L, Chen Z, Tighiouart M, Shin DM, Chen ZG. PMID: 22829201; PMCID: PMC3462074.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    57. A pragmatic approach using magnetic resonance imaging to treat ischemic strokes of unknown onset time in a thrombolytic trial. Stroke. 2012 Sep; 43(9):2331-5. Song SS, Latour LL, Ritter CH, Wu O, Tighiouart M, Hernandez DA, Ku KD, Luby M, Warach S. PMID: 22693129; PMCID: PMC3464959.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    58. Dose escalation with overdose control using a quasi-continuous toxicity score in cancer Phase I clinical trials. Contemp Clin Trials. 2012 Sep; 33(5):949-58. Chen Z, Tighiouart M, Kowalski J. PMID: 22561391; PMCID: PMC4046335.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    59. Early clearance of peripheral blood blasts predicts response to induction chemotherapy in acute myeloid leukemia. Cancer. 2012 Nov 01; 118(21):5278-82. Arellano M, Pakkala S, Langston A, Tighiouart M, Pan L, Chen Z, Heffner LT, Lonial S, Winton E, Khoury HJ. PMID: 22517268.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    60. Med1 plays a critical role in the development of tamoxifen resistance. Carcinogenesis. 2012 Apr; 33(4):918-30. Nagalingam A, Tighiouart M, Ryden L, Joseph L, Landberg G, Saxena NK, Sharma D. PMID: 22345290; PMCID: PMC3324449.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    61. Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer. Eur J Cancer. 2012 Jul; 48(11):1682-91. Xu J, Müller S, Nannapaneni S, Pan L, Wang Y, Peng X, Wang D, Tighiouart M, Chen Z, Saba NF, Beitler JJ, Shin DM, Chen ZG. PMID: 22341992; PMCID: PMC3381072.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    62. A phase 1 dose escalation study of bortezomib combined with rituximab, cyclophosphamide, doxorubicin, modified vincristine, and prednisone for untreated follicular lymphoma and other low-grade B-cell lymphomas. Cancer. 2012 Jul 15; 118(14):3538-48. Sinha R, Kaufman JL, Khoury HJ, King N, Shenoy PJ, Lewis C, Bumpers K, Hutchison-Rzepka A, Tighiouart M, Heffner LT, Lechowicz MJ, Lonial S, Flowers CR. PMID: 22535574.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    63. A dual-targeting antibody against EGFR-VEGF for lung and head and neck cancer treatment. Int J Cancer. 2012 Aug 15; 131(4):956-69. Zhang H, Yun S, Batuwangala TD, Steward M, Holmes SD, Pan L, Tighiouart M, Shin HJ, Koenig L, Park W, Rycroft D, Nannapaneni S, Wang Y, Chen ZG, Shin DM. PMID: 21918971.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    64. Pharmacodynamics of DT-IgG, a dual-targeting antibody against VEGF-EGFR, in tumor xenografted mice. Cancer Chemother Pharmacol. 2012 Mar; 69(3):577-90. Hurwitz SJ, Zhang H, Yun S, Batuwangala TD, Steward M, Holmes SD, Rycroft D, Pan L, Tighiouart M, Shin HJ, Koenig L, Wang Y, Chen ZG, Shin DM. PMID: 21913035.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    65. A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model. ACS Nano. 2011 Aug 23; 5(8):6184-94. Wang X, Li J, Wang Y, Koenig L, Gjyrezi A, Giannakakou P, Shin EH, Tighiouart M, Chen ZG, Nie S, Shin DM. PMID: 21728341; PMCID: PMC3773705.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    66. High-dose cytarabine induction is well tolerated and active in patients with de novo acute myeloid leukemia older than 60 years. Cancer. 2012 Jan 15; 118(2):428-33. Arellano M, Winton E, Pan L, Lima L, Tighiouart M, Bhalla K, Heffner LT, Neely J, Hutcherson D, McLemore M, Langston A, Khoury HJ. PMID: 21717443.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    67. Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells. Mol Cancer Ther. 2011 Aug; 10(8):1460-9. Liu T, Yacoub R, Taliaferro-Smith LD, Sun SY, Graham TR, Dolan R, Lobo C, Tighiouart M, Yang L, Adams A, O'Regan RM. PMID: 21690228; PMCID: PMC4908959.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    68. Prognostic significance of leukopenia at the time of diagnosis in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2011 Oct; 11(5):427-32. Arellano M, Bernal-Mizrachi L, Pan L, Tighiouart M, Souza L, Guo X, McLemore M, Lima L, Sunay S, Heffner LT, Chen Z, Chen GZ, Langston A, Winton E, Khoury HJ. PMID: 21729688.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    69. Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. Int J Cancer. 2011 Dec 01; 129(11):2744-55. Thaiparambil JT, Bender L, Ganesh T, Kline E, Patel P, Liu Y, Tighiouart M, Vertino PM, Harvey RD, Garcia A, Marcus AI. PMID: 21538350.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    70. Does pretreatment fluorescence in situ hybridization for BCR-ABL predict imatinib-associated hematologic toxicity in chronic myeloid leukemia? Leuk Lymphoma. 2011 Jun; 52(6):1010-6. Lima LM, Sampat K, Assouline S, Saxe D, Nault S, Tighiouart M, McLemore M, Arellano M, Winton E, Bernal-Mizrachi L, Cortes J, Khoury HJ. PMID: 21504383.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    71. Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. Am J Surg Pathol. 2011 Jan; 35(1):70-5. Deyrup AT, Miettinen M, North PE, Khoury JD, Tighiouart M, Spunt SL, Parham DM, Shehata BM, Weiss SW. PMID: 21164289.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    72. Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis. Head Neck. 2011 Oct; 33(10):1501-12. Kline ER, Muller S, Pan L, Tighiouart M, Chen ZG, Marcus AI. PMID: 21928424.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    73. Peripheral blood monitoring of chronic myeloid leukemia during treatment with imatinib, second-line agents, and beyond. Cancer. 2011 Mar 15; 117(6):1245-52. Lima L, Bernal-Mizrachi L, Saxe D, Mann KP, Tighiouart M, Arellano M, Heffner L, McLemore M, Langston A, Winton E, Khoury HJ. PMID: 21381013.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    74. Receiver operating characteristic curve analysis of circulating blood dendritic cell precursors and T cells predicts response to extracorporeal photopheresis in patients with chronic graft-versus-host disease. Transfusion. 2010 Nov; 50(11):2424-31. Akhtari M, Giver CR, Ali Z, Flowers CR, Gleason CL, Hillyer CD, Kaufman J, Khoury HJ, Langston AA, Lechowicz MJ, Lonial S, Renfroe HM, Roback JD, Tighiouart M, Vaughn L, Waller EK. PMID: 20529004; PMCID: PMC3926317.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    75. Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53. J Biol Chem. 2010 Nov 05; 285(45):34557-65. Amin AR, Wang D, Zhang H, Peng S, Shin HJ, Brandes JC, Tighiouart M, Khuri FR, Chen ZG, Shin DM. PMID: 20826787; PMCID: PMC2966071.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    76. caGrid-Enabled caBIG Silver Level Compatible Head and Neck Cancer Tissue Database System. Open Med Inform J. 2010 Sep 01; 4:171-8. Wang H, Bouzyk E, Kuehn A, Muller S, Chen Z, Khuri FR, Shin DM, Rogatko A, Tighiouart M. PMID: 21589853; PMCID: PMC3095113.
      View in: PubMed   Mentions:
    77. A phase I/II trial combining high-dose melphalan and autologous transplant with bortezomib for multiple myeloma: a dose- and schedule-finding study. Clin Cancer Res. 2010 Oct 15; 16(20):5079-86. Lonial S, Kaufman J, Tighiouart M, Nooka A, Langston AA, Heffner LT, Torre C, McMillan S, Renfroe H, Harvey RD, Lechowicz MJ, Khoury HJ, Flowers CR, Waller EK. PMID: 20739431.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCTClinical Trials
    78. Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact. PLoS One. 2010 Aug 16; 5(8):e12178. Elrod HA, Fan S, Muller S, Chen GZ, Pan L, Tighiouart M, Shin DM, Khuri FR, Sun SY. PMID: 20808443; PMCID: PMC2922336.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    79. Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer. 2010 Aug 15; 116(16):3903-9. Ramalingam SS, Harvey RD, Saba N, Owonikoko TK, Kauh J, Shin DM, Sun SY, Strychor S, Tighiouart M, Egorin MJ, Fu H, Khuri FR. PMID: 20564143; PMCID: PMC2940062.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    80. Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology. 2010 Nov; 139(5):1762-73, 1773.e1-5. Saxena NK, Fu PP, Nagalingam A, Wang J, Handy J, Cohen C, Tighiouart M, Sharma D, Anania FA. PMID: 20637208; PMCID: PMC2967590.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    81. A novel toxicity scoring system treating toxicity response as a quasi-continuous variable in Phase I clinical trials. Contemp Clin Trials. 2010 Sep; 31(5):473-82. Chen Z, Krailo MD, Azen SP, Tighiouart M. PMID: 20609419; PMCID: PMC4871599.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    82. Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: a retrospective single-institution analysis. Head Neck. 2009 Nov; 31(11):1447-55. Saba NF, Edelman S, Tighiouart M, Gaultney J, Davis LW, Khuri FR, Chen A, Grist W, Shin DM. PMID: 19431199.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    83. HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors. ACS Nano. 2009 Oct 27; 3(10):3165-74. Wang X, Li J, Wang Y, Cho KJ, Kim G, Gjyrezi A, Koenig L, Giannakakou P, Shin HJ, Tighiouart M, Nie S, Chen ZG, Shin DM. PMID: 19761191; PMCID: PMC3733355.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    84. Sequence dependence of cell growth inhibition by EGFR-tyrosine kinase inhibitor ZD1839, docetaxel, and cisplatin in head and neck cancer. Head Neck. 2009 Oct; 31(10):1263-73. Klass CM, Choe MS, Hurwitz SJ, Tighiouart M, Zhang X, Chen ZG, Shin DM. PMID: 19399750; PMCID: PMC3600558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    85. Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 2009 Sep; 2(9):823-9. Saba NF, Choi M, Muller S, Shin HJ, Tighiouart M, Papadimitrakopoulou VA, El-Naggar AK, Khuri FR, Chen ZG, Shin DM. PMID: 19737986; PMCID: PMC2910364.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    86. Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma. Int J Radiat Oncol Biol Phys. 2010 May 01; 77(1):106-12. Korah MP, Esiashvili N, Mazewski CM, Hudgins RJ, Tighiouart M, Janss AJ, Schwaibold FP, Crocker IR, Curran WJ, Marcus RB. PMID: 19695790.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    87. Examining expression of folate receptor in squamous cell carcinoma of the head and neck as a target for a novel nanotherapeutic drug. Head Neck. 2009 Apr; 31(4):475-81. Saba NF, Wang X, Müller S, Tighiouart M, Cho K, Nie S, Chen Z, Shin DM. PMID: 19072997; PMCID: PMC2658731.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    88. Excellent local control from radiation therapy for high-risk neuroblastoma. Int J Radiat Oncol Biol Phys. 2009 Aug 01; 74(5):1549-54. Gatcombe HG, Marcus RB, Katzenstein HM, Tighiouart M, Esiashvili N. PMID: 19211198.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    89. Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. Am J Surg Pathol. 2009 Feb; 33(2):264-9. Deyrup AT, Miettinen M, North PE, Khoury JD, Tighiouart M, Spunt SL, Parham D, Weiss SW, Shehata BM. PMID: 18987547.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    90. Restoration of caveolin-1 expression suppresses growth and metastasis of head and neck squamous cell carcinoma. Br J Cancer. 2008 Nov 18; 99(10):1684-94. Zhang H, Su L, Müller S, Tighiouart M, Xu Z, Zhang X, Shin HJ, Hunt J, Sun SY, Shin DM, Chen ZG. PMID: 19002186; PMCID: PMC2584955.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    91. BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res. 2008 Sep 01; 68(17):6953-62. Ventii KH, Devi NS, Friedrich KL, Chernova TA, Tighiouart M, Van Meir EG, Wilkinson KD. PMID: 18757409; PMCID: PMC2736608.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    92. Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor. Int J Cancer. 2008 Sep 01; 123(5):1005-14. Zhang X, Zhang H, Tighiouart M, Lee JE, Shin HJ, Khuri FR, Yang CS, Chen Z', Shin DM. PMID: 18546267; PMCID: PMC2555987.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    93. Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and nonmetastatic head and neck squamous cell carcinoma: predictive and prognostic correlation. Cancer. 2008 Jul 01; 113(1):97-107. Muller S, Su L, Tighiouart M, Saba N, Zhang H, Shin DM, Chen Z. PMID: 18473353.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    94. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol. 2008 Jun; 32(6):924-7. Deyrup AT, Tighiouart M, Montag AG, Weiss SW. PMID: 18551749.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    95. Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma. Oral Oncol. 2008 Nov; 44(11):1039-46. McLean N, Tighiouart M, Muller S. PMID: 18396446.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    96. Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res. 2008 Apr 01; 68(7):2479-88. Graham TR, Zhau HE, Odero-Marah VA, Osunkoya AO, Kimbro KS, Tighiouart M, Liu T, Simons JW, O'Regan RM. PMID: 18381457.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
    97. Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol. 2008 Jan; 32(1):72-7. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, Weiss SW. PMID: 18162773.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    98. Translation of innovative designs into phase I trials. J Clin Oncol. 2007 Nov 01; 25(31):4982-6. Rogatko A, Schoeneck D, Jonas W, Tighiouart M, Khuri FR, Porter A. PMID: 17971597.
      View in: PubMed   Mentions: 84     Fields:    Translation:Humans
    99. Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4. Cancer Res. 2007 Jul 15; 67(14):6872-81. Post DE, Sandberg EM, Kyle MM, Devi NS, Brat DJ, Xu Z, Tighiouart M, Van Meir EG. PMID: 17638898; PMCID: PMC2262867.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    100. Prevalence and correlates of tobacco use among Russian cancer patients: implications for the development of smoking cessation interventions at a cancer center in Russia. Int J Behav Med. 2006; 13(1):16-25. Schnoll RA, Engstrom PF, Subramanian S, Demidov L, Wielt DB, Tighiouart M. PMID: 16503837.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    101. Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma. Cancer. 2005 Aug 01; 104(3):561-9. Kim ES, Kies MS, Fossella FV, Glisson BS, Zaknoen S, Statkevich P, Munden RF, Summey C, Pisters KM, Papadimitrakopoulou V, Tighiouart M, Rogatko A, Khuri FR. PMID: 16028213.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    102. New paradigm in dose-finding trials: patient-specific dosing and beyond phase I. Clin Cancer Res. 2005 Aug 01; 11(15):5342-6. Rogatko A, Babb JS, Tighiouart M, Khuri FR, Hudes G. PMID: 16061846.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    103. Flexible Bayesian methods for cancer phase I clinical trials. Dose escalation with overdose control. Stat Med. 2005 Jul 30; 24(14):2183-96. Tighiouart M, Rogatko A, Babb JS. PMID: 15909291.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
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