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Repurposing of the analgesic Neurotropin for MASLD/MASH treatment. Hepatol Commun. 2024 Aug 01; 8(8).
Tsuchiya T, Kim SY, Matsuda M, Kim J, Stotland A, Naiki M, Seki E. PMID: 39023282; PMCID: PMC11262822.
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PubMed Mentions: Fields:
Translation:
Animals
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Hepatocyte programmed cell death: the trigger for inflammation and fibrosis in metabolic dysfunction-associated steatohepatitis. Front Cell Dev Biol. 2024; 12:1431921.
Cheng Z, Chu H, Seki E, Lin R, Yang L. PMID: 39071804; PMCID: PMC11272544.
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Unveiling the cancer risk nexus of the steatotic liver. Trends Endocrinol Metab. 2024 Aug; 35(8):708-719.
Kim J, Seki E. PMID: 38531699; PMCID: PMC11321945.
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HumansAnimals
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S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. Int J Biol Sci. 2024; 20(4):1218-1237.
Barbier-Torres L, Chhimwal J, Kim SY, Ramani K, Robinson A, Yang H, Van Eyk J, Liangpunsakul S, Seki E, Mato JM, Lu SC. PMID: 38385082; PMCID: PMC10878152.
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HumansCells
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Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis. J Hepatol. 2024 Mar; 80(3):443-453.
Fan W, Cao D, Yang B, Wang J, Li X, Kitka D, Li TWH, You S, Shiao S, Gangi A, Posadas E, Di Vizio D, Tomasi ML, Seki E, Mato JM, Yang H, Lu SC. PMID: 38086446; PMCID: PMC10922446.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations. Cell Mol Gastroenterol Hepatol. 2023; 16(3):355-367.
Lee YS, Seki E. PMID: 37270060; PMCID: PMC10444957.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment. Cell Metab. 2023 07 11; 35(7):1209-1226.e13.
Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang YM, Matsuda M, Reolizo L, Tsuchiya T, Billet S, Gangi A, Noureddin M, Falk BA, Kim S, Fan W, Tighiouart M, You S, Lewis MS, Pandol SJ, Di Vizio D, Merchant A, Posadas EM, Bhowmick NA, Lu SC, Seki E. PMID: 37172577; PMCID: PMC10524732.
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PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Correction: Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2023 Apr 18; 12.
Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E. PMID: 37071069; PMCID: PMC10112883.
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Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets. Hepatol Commun. 2023 04 01; 7(4).
Kim J, Seki E. PMID: 36930869; PMCID: PMC10027054.
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4 Fields:
Translation:
HumansCells
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FAP: Not Just a Biomarker but Druggable Target in Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2023; 15(4):1018-1019.
Kim J, Seki E. PMID: 36681094; PMCID: PMC10040959.
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Humans
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Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. J Hepatol. 2023 04; 78(4):805-819.
Tao L, Yang G, Sun T, Zhu C, Yu H, Cheng Y, Yang Z, Xu M, Jiang Y, Zhang W, Wang Z, Ma W, Wu L, Xue D, Wang D, Yang W, Zhao Y, Horsefield S, Kobe B, Zhang Z, Tang Z, Li Q, Zhai Q, Dooley S, Seki E, Liu P, Xu J, Chen H, Liu C. PMID: 36669703.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Experimental Workflow for Preclinical Studies of Human Antifibrotic Therapies. Methods Mol Biol. 2023; 2669:285-306.
Reolizo L, Matsuda M, Seki E. PMID: 37247068.
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HumansAnimals
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Breast cancer liver metastasis: Pathogenesis and clinical implications. Front Oncol. 2022; 12:1043771.
Liu C, Mohan SC, Wei J, Seki E, Liu M, Basho R, Giuliano AE, Zhao Y, Cui X. PMID: 36387238; PMCID: PMC9641291.
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PubMed Mentions:
4
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Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2022 10 04; 11.
Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E. PMID: 36193675; PMCID: PMC9531947.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B. Can J Gastroenterol Hepatol. 2022; 2022:1048104.
Yang G, Zhuang L, Sun T, Yeo YH, Tao L, Zhang W, Ma W, Wu L, Yang Z, Yang Y, Xue D, Zhang J, Feng R, Matthias P E, Dooley S, Seki E, Liu P, Liu C. PMID: 35855954; PMCID: PMC9288342.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. Exp Mol Med. 2022 06; 54(6):739-752.
Kim SM, Song GY, Shim A, Lee JH, Eom CB, Liu C, Yang YM, Seki E. PMID: 35662287; PMCID: PMC9256637.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease. Nat Commun. 2022 01 28; 13(1):557.
Barbier-Torres L, Murray B, Yang JW, Wang J, Matsuda M, Robinson A, Binek A, Fan W, Fernández-Ramos D, Lopitz-Otsoa F, Luque-Urbano M, Millet O, Mavila N, Peng H, Ramani K, Gottlieb R, Sun Z, Liangpunsakul S, Seki E, Van Eyk JE, Mato JM, Lu SC. PMID: 35091576; PMCID: PMC8799735.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Hepatocyte TGF-β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p. Hepatol Commun. 2022 06; 6(6):1301-1321.
Zhao J, Hu L, Gui W, Xiao L, Wang W, Xia J, Fan H, Li Z, Zhu Q, Hou X, Chu H, Seki E, Yang L. PMID: 35018737; PMCID: PMC9134819.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis. Front Cell Dev Biol. 2021; 9:734749.
Wang W, Gao W, Zhu Q, Alasbahi A, Seki E, Yang L. PMID: 34722513; PMCID: PMC8551703.
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PubMed Mentions:
9
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An Intestine-Derived HDL as a Novel Regulator of the Activity of Gut-Derived LPS: Ushering in a New Era of Research on the Gut-Liver Axis. Gastroenterology. 2022 02; 162(2):651-652.
Kim J, Seki E. PMID: 34571025; PMCID: PMC8792181.
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PubMed Mentions:
2 Fields:
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Crossing the Rubicon: Adipose Tissue Autophagy Breaks Out NAFLD. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1877-1878.
Kim J, Seki E. PMID: 34461065; PMCID: PMC8591194.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans. Oncogene. 2021 Sep; 40(39):5866-5879.
Lu L, Zhang J, Fan W, Li Y, Wang J, Li TWH, Barbier-Torres L, Mato JM, Liu T, Seki E, Matsuda M, Tomasi ML, Bhowmick NA, Yang H, Lu SC. PMID: 34349244; PMCID: PMC9611740.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Modeling alcohol-associated liver disease in a human Liver-Chip. Cell Rep. 2021 07 20; 36(3):109393.
Nawroth JC, Petropolis DB, Manatakis DV, Maulana TI, Burchett G, Schlünder K, Witt A, Shukla A, Kodella K, Ronxhi J, Kulkarni G, Hamilton G, Seki E, Lu S, Karalis KC. PMID: 34289365; PMCID: PMC8342038.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 Jun 14; 39(6):883.
Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. PMID: 34129825; PMCID: PMC8532387.
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PubMed Mentions:
30 Fields:
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Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 2021 06 01; 131(11).
Bhattacharjee S, Hamberger F, Ravichandra A, Miller M, Nair A, Affo S, Filliol A, Chin L, Savage TM, Yin D, Wirsik NM, Mehal A, Arpaia N, Seki E, Mack M, Zhu D, Sims PA, Kalluri R, Stanger BZ, Olive KP, Schmidt T, Wells RG, Mederacke I, Schwabe RF. PMID: 33905375; PMCID: PMC8159701.
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PubMed Mentions:
91 Fields:
Translation:
HumansAnimalsCells
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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 06 14; 39(6):866-882.e11.
Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. PMID: 33930309; PMCID: PMC8241235.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, et al. PMID: 33634751; PMCID: PMC7996087.
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PubMed Mentions:
986 Fields:
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HumansAnimalsCells
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Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43. Cell Metab. 2021 02 02; 33(2):229-230.
Yang YM, Seki E. PMID: 33535096; PMCID: PMC8407036.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. Arch Pharm Res. 2021 Feb; 44(2):230-240.
Yang YM, Wang Z, Matsuda M, Seki E. PMID: 33486695; PMCID: PMC8407017.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1).
Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E. PMID: 33443222; PMCID: PMC7817133.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis. Transplant Direct. 2020 Nov; 6(11):e612.
Noureddin N, Yang JD, Alkhouri N, Noreen SM, Toll AE, Todo T, Ayoub W, Kuo A, Voidonikolas G, Kotler HG, Pelphrey MD, Durand BJ, Kosari K, Brennan TV, Kim I, Klein AS, Seki E, Nissen NN, Lu SC, Sundaram V, Noureddin M. PMID: 33134488; PMCID: PMC7546885.
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PubMed Mentions:
1
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Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700.
Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC. PMID: 32080887; PMCID: PMC7442711.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation. Front Physiol. 2020; 11:950.
Wang Q, Wang Z, Xu M, Tu W, Hsin IF, Stotland A, Kim JH, Liu P, Naiki M, Gottlieb RA, Seki E. PMID: 32848877; PMCID: PMC7424056.
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PubMed Mentions:
3
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The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix. Food Chem Toxicol. 2020 Sep; 143:111556.
Matsuda M, Seki E. PMID: 32640349; PMCID: PMC7484466.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis. Semin Liver Dis. 2020 Aug; 40(3):307-320.
Matsuda M, Seki E. PMID: 32242330; PMCID: PMC7484001.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury. Cell Mol Gastroenterol Hepatol. 2020; 9(1):187-188.
Czech TY, Seki E. PMID: 31669157; PMCID: PMC6926269.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. J Biol Chem. 2019 08 16; 294(33):12359-12369.
Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E. PMID: 31235522; PMCID: PMC6699832.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Sci Transl Med. 2019 06 12; 11(496).
Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E. PMID: 31189722; PMCID: PMC6589184.
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PubMed Mentions:
59 Fields:
Translation:
HumansCells
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Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. Gut. 2019 12; 68(12):2214-2227.
Tao L, Ma W, Wu L, Xu M, Yang Y, Zhang W, Sha W, Li H, Xu J, Feng R, Xue D, Zhang J, Dooley S, Seki E, Liu P, Liu C. PMID: 31171625; PMCID: PMC6842044.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 11; 70(5):1582-1599.
Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. PMID: 31044438; PMCID: PMC6819206.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death Dis. 2019 02 11; 10(2):120.
Wang P, Song X, Utpatel K, Shang R, Yang YM, Xu M, Zhang J, Che L, Gordan J, Cigliano A, Seki E, Evert M, Calvisi DF, Hu X, Chen X. PMID: 30741922; PMCID: PMC6370758.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Intestinal Lipolysis Mitigates Nonalcoholic Fatty Liver Disease: New Roles for Carboxylesterase 2c in the Intestine. Hepatol Commun. 2019 Feb; 3(2):177-179.
Pimienta M, Beletsky A, Seki E. PMID: 30766955; PMCID: PMC6357825.
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PubMed Mentions: Fields:
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Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets. Semin Liver Dis. 2019 02; 39(1):26-42.
Yang YM, Kim SY, Seki E. PMID: 30809789; PMCID: PMC6616367.
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PubMed Mentions:
175 Fields:
Translation:
HumansCells
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Alcoholic liver disease: A current molecular and clinical perspective. Liver Res. 2018 Dec; 2(4):161-172.
Ohashi K, Pimienta M, Seki E. PMID: 31214376; PMCID: PMC6581514.
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PubMed Mentions:
41
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The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. J Biol Chem. 2019 02 08; 294(6):1984-1996.
Yang JW, Murray B, Barbier-Torres L, Liu T, Liu Z, Yang H, Fan W, Wang J, Li Y, Seki E, Mato JM, Lu SC. PMID: 30523154; PMCID: PMC6369293.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest. 2018 12 03; 128(12):5587-5602.
Kim TH, Yang YM, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. PMID: 30300140; PMCID: PMC6264648.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888.
Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485; PMCID: PMC6196518.
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PubMed Mentions:
49 Fields:
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HumansAnimalsCells
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Nuclear Receptors: Opening Up New Avenues of Pediatric Fatty Liver Research. Hepatol Commun. 2018 Oct; 2(10):1157-1159.
Pandyarajan V, Seki E. PMID: 30288469; PMCID: PMC6167071.
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PubMed Mentions: Fields:
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MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis. Arch Toxicol. 2018 09; 92(9):2935-2946.
Tao L, Xue D, Shen D, Ma W, Zhang J, Wang X, Zhang W, Wu L, Pan K, Yang Y, Nwosu ZC, Dooley S, Seki E, Liu C. PMID: 30097701; PMCID: PMC6590087.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203.
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112; PMCID: PMC6329306.
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PubMed Mentions:
477 Fields:
Translation:
AnimalsCells
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Interventional Potential of Recombinant Feline Hepatocyte Growth Factor in a Mouse Model of Non-alcoholic Steatohepatitis. Front Endocrinol (Lausanne). 2018; 9:378.
Yang YM, Fukui M, Wang Z, Miao F, Karriker MJ, Seki E. PMID: 30083132; PMCID: PMC6064873.
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9 Fields:
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Tumor Suppressor Down-Regulation Promotes Hepatocyte Proliferation: A New GANKster on the Block. Cell Mol Gastroenterol Hepatol. 2018; 6(3):345-346.
Pimienta M, Seki E. PMID: 30182043; PMCID: PMC6120958.
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Cells
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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 06 11; 33(6):1061-1077.e6.
Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, Karin M. PMID: 29894692; PMCID: PMC6005359.
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PubMed Mentions:
100 Fields:
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HumansAnimalsCells
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Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer. Gastroenterology. 2018 08; 155(2):557-571.e14.
Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC. PMID: 29733835; PMCID: PMC6067975.
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PubMed Mentions:
44 Fields:
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HumansAnimalsCells
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Astrocyte elevated gene-1 (AEG-1): a new potential therapeutic target for the treatment of nonalcoholic steatohepatitis (NASH). Hepatobiliary Surg Nutr. 2018 Feb; 7(1):44-47.
Wang Q, Seki E. PMID: 29531945; PMCID: PMC5835612.
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A new mechanism of action of glucagon-like peptide-1 agonist in hepatic steatosis: Promotion of hepatic insulin clearance through induction of carcinoembryonic antigen-related cell adhesion molecule 1. Hepatol Commun. 2018 01; 2(1):9-12.
Czech TY, Wang Q, Seki E. PMID: 29404506; PMCID: PMC5776878.
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2 Fields:
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Chemokines and Chemokine Receptors in the Development of NAFLD. Adv Exp Med Biol. 2018; 1061:45-53.
Roh YS, Seki E. PMID: 29956205.
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PubMed Mentions:
41 Fields:
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HumansAnimals
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The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer. 2018 01 01; 142(1):81-91.
Song IJ, Yang YM, Inokuchi-Shimizu S, Roh YS, Yang L, Seki E. PMID: 28875549; PMCID: PMC5790193.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. Oncotarget. 2017 Oct 03; 8(45):78851-78869.
Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC. PMID: 29108270; PMCID: PMC5668003.
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17 Fields:
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TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 May; 3(3):469-483.
Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E. PMID: 28462384; PMCID: PMC5403956.
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33 Fields:
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LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis. Sci Rep. 2016 10 18; 6:35610.
Odena G, Chen J, Lozano JJ, Altamirano J, Rodrigo-Torres D, Affo S, Morales-Ibanez O, Matsushita H, Zou J, Dumitru R, Caballeria J, Gines P, Arroyo V, You M, Rautou PE, Valla D, Crews F, Seki E, Sancho-Bru P, Bataller R. PMID: 27752144; PMCID: PMC5067590.
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17 Fields:
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HumansAnimalsCells
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Acrolein, a New Villain in the Development of Alcoholic Liver Disease. Cell Mol Gastroenterol Hepatol. 2016 Sep; 2(5):544-545.
Seki E. PMID: 28174735; PMCID: PMC5042884.
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1 Fields:
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Finding a new role for NEMO: A key player in preventing hepatocyte apoptosis and liver tumorigenesis by inhibiting RIPK1. Hepatology. 2016 07; 64(1):295-7.
Hsin IF, Montano E, Seki E. PMID: 27122117; PMCID: PMC4917439.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. 2016 06 13; 29(6):935-948.
Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 27211490; PMCID: PMC4907799.
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PubMed Mentions:
231 Fields:
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HumansAnimalsCells
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Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells. PLoS One. 2016; 11(3):e0150893.
Siegmund SV, Schlosser M, Schildberg FA, Seki E, De Minicis S, Uchinami H, Kuntzen C, Knolle PA, Strassburg CP, Schwabe RF. PMID: 26937641; PMCID: PMC4777566.
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PubMed Mentions:
33 Fields:
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HumansAnimalsCells
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Exosome Migration Inhibitory Factor as a Marker and Therapeutic Target for Pancreatic Cancer. Gastroenterology. 2016 Apr; 150(4):1033-5.
Matsushita H, Yang YM, Pandol SJ, Seki E. PMID: 26922869; PMCID: PMC4905572.
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PubMed Mentions:
11 Fields:
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HumansAnimalsCells
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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25; 164(5):896-910.
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. PMID: 26919428; PMCID: PMC4769378.
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PubMed Mentions:
525 Fields:
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AnimalsCells
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Basic and Clinical Advances in Chronic Liver Inflammation. Mediators Inflamm. 2016; 2016:1571457.
Enomoto H, Tamori A, Yoshiji H, Seki E. PMID: 27006527; PMCID: PMC4783579.
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HumansAnimals
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HEDGEHOG Signal in hepatocytes mediates macrophage recruitment: A new mechanism and potential therapeutic target for fatty liver disease. Hepatology. 2016 Apr; 63(4):1071-3.
Seki E. PMID: 26638191; PMCID: PMC4805480.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222.
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
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PubMed Mentions:
2804 Fields:
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HumansAnimals
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MafG, A Novel Target of FXR that Regulates Bile Acid Homeostasis. Gastroenterology. 2015 Dec; 149(7):1981-3.
Yang YM, Roh YS, Seki E. PMID: 26501563; PMCID: PMC4744927.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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TNFα in liver fibrosis. Curr Pathobiol Rep. 2015 Dec; 3(4):253-261.
Yang YM, Seki E. PMID: 26726307; PMCID: PMC4693602.
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PubMed Mentions:
77
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Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Dec; 149(7):1784-93.
Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin CB, Brenner D, Genetics of NAFLD in Twins Consortium. PMID: 26299412; PMCID: PMC4663110.
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PubMed Mentions:
161 Fields:
Translation:
Humans
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TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration. Am J Physiol Gastrointest Liver Physiol. 2015 Jul 01; 309(1):G30-41.
Roh YS, Zhang B, Loomba R, Seki E. PMID: 25930080; PMCID: PMC4491507.
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PubMed Mentions:
69 Fields:
Translation:
AnimalsCells
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Recent advancement of molecular mechanisms of liver fibrosis. J Hepatobiliary Pancreat Sci. 2015 Jul; 22(7):512-8.
Seki E, Brenner DA. PMID: 25869468; PMCID: PMC4668270.
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PubMed Mentions:
138 Fields:
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HumansAnimalsCells
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Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice. Hepatology. 2015 Apr; 61(4):1357-69.
Maricic I, Sheng H, Marrero I, Seki E, Kisseleva T, Chaturvedi S, Molle N, Mathews SA, Gao B, Kumar V. PMID: 25477000; PMCID: PMC4376634.
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PubMed Mentions:
49 Fields:
Translation:
AnimalsCells
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Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology. 2015 Mar; 61(3):1066-79.
Seki E, Schwabe RF. PMID: 25066777; PMCID: PMC4306641.
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PubMed Mentions:
409 Fields:
Translation:
HumansCells
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TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. Mol Cell Oncol. 2014; 1(4).
Seki E. PMID: 26709386; PMCID: PMC4687902.
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PubMed Mentions:
6
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Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. PLoS One. 2014; 9(12):e114071.
Zhang B, Roh YS, Liang S, Liu C, Naiki M, Masuda K, Seki E. PMID: 25470242; PMCID: PMC4254918.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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The TM6SF2 variants, novel genetic predictors for nonalcoholic steatohepatitis. Gastroenterology. 2015 Jan; 148(1):252-4.
Roh YS, Loomba R, Seki E. PMID: 25451657; PMCID: PMC4718074.
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10 Fields:
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Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2015 Mar; 13(3):561-568.e1.
Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, Seki E, Sirlin CB, Loomba R. PMID: 25218667; PMCID: PMC4333065.
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PubMed Mentions:
62 Fields:
Translation:
Humans
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ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 2014 Sep 08; 26(3):331-343.
Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. PMID: 25132496; PMCID: PMC4165611.
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PubMed Mentions:
280 Fields:
Translation:
AnimalsCells
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Reply: To PMID 23996730. Hepatology. 2014 Sep; 60(3):1114-5.
Yang L, Seki E. PMID: 24443149; PMCID: PMC4328032.
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AnimalsCells
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GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Nat Commun. 2014 Jul 21; 5:4451.
Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P. PMID: 25043713; PMCID: PMC4107319.
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PubMed Mentions:
49 Fields:
Translation:
HumansAnimalsCells
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Nrf2 activation protects the liver from ischemia/reperfusion injury in mice. Ann Surg. 2014 Jul; 260(1):118-27.
Kudoh K, Uchinami H, Yoshioka M, Seki E, Yamamoto Y. PMID: 24368646; PMCID: PMC4047210.
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PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
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TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78.
Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. PMID: 24983318; PMCID: PMC4109552.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metab. 2014 Jul 01; 20(1):133-44.
Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. PMID: 24910242; PMCID: PMC4079758.
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PubMed Mentions:
93 Fields:
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HumansAnimalsCells
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Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis. Hepatology. 2014 Jul; 60(1):237-49.
Roh YS, Park S, Kim JW, Lim CW, Seki E, Kim B. PMID: 24375615; PMCID: PMC4273749.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Novel fate-tracing strategies show that hepatic stellate cells mediate fibrosis in vivo. Gastroenterology. 2014 Jun; 146(7):1823-5.
Liang S, Zhong Z, Seki E. PMID: 24768331; PMCID: PMC4743044.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Microbiome-obesity-liver cancer interaction: senescence of hepatic stellate cells and bile acids play new roles. Gastroenterology. 2014 Mar; 146(3):860-1.
Seki E. PMID: 24468171; PMCID: PMC4717838.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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TAK1 regulates hepatic cell survival and carcinogenesis. J Gastroenterol. 2014 Feb; 49(2):185-94.
Roh YS, Song J, Seki E. PMID: 24443058; PMCID: PMC3952073.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
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Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem. 2014 Mar 07; 289(10):7082-7091.
Liu C, Chen X, Yang L, Kisseleva T, Brenner DA, Seki E. PMID: 24448807; PMCID: PMC3945368.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet. Cell Metab. 2014 Jan 07; 19(1):6-7.
Dhar D, Seki E, Karin M. PMID: 24411937; PMCID: PMC3947913.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. Hepatology. 2014 Feb; 59(2):483-95.
Yang L, Roh YS, Song J, Zhang B, Liu C, Loomba R, Seki E. PMID: 23996730; PMCID: PMC3946696.
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PubMed Mentions:
127 Fields:
Translation:
AnimalsCells
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A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol. 2014 Apr; 60(4):782-91.
Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. PMID: 24333183; PMCID: PMC3960359.
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PubMed Mentions:
84 Fields:
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HumansAnimalsCells
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Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract. 2013; 2013:498296.
Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin CB, Loomba R. PMID: 24348536; PMCID: PMC3855930.
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PubMed Mentions:
27
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Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 2013 Oct 10; 155(2):384-96.
He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. PMID: 24120137; PMCID: PMC4015514.
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PubMed Mentions:
234 Fields:
Translation:
AnimalsCells
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Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:38-42.
Roh YS, Seki E. PMID: 23855294; PMCID: PMC3721430.
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PubMed Mentions:
144 Fields:
Translation:
HumansAnimalsCells
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Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Gastroenterology. 2013 May; 144(5):1042-1054.e4.
Yang L, Inokuchi S, Roh YS, Song J, Loomba R, Park EJ, Seki E. PMID: 23391818; PMCID: PMC3752402.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology. 2013 Feb; 57(2):577-89.
Miura K, Yang L, van Rooijen N, Brenner DA, Ohnishi H, Seki E. PMID: 22987396; PMCID: PMC3566276.
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PubMed Mentions:
144 Fields:
Translation:
AnimalsCells
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p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Res. 2013 Jan 01; 73(1):215-24.
Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. PMID: 23271722; PMCID: PMC3605785.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimals
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A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 2012 Aug; 143(2):307-20.
Seki E, Brenner DA, Karin M. PMID: 22705006; PMCID: PMC3523093.
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PubMed Mentions:
244 Fields:
Translation:
HumansAnimalsCells
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CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction. Cancer Cell. 2012 Jun 12; 21(6):711-2.
Font-Burgada J, Seki E, Karin M. PMID: 22698394; PMCID: PMC4718070.
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4 Fields:
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Origin of myofibroblasts in liver fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S17.
Brenner DA, Kisseleva T, Scholten D, Paik YH, Iwaisako K, Inokuchi S, Schnabl B, Seki E, De Minicis S, Oesterreicher C, Taura K. PMID: 23259769; PMCID: PMC3368775.
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PubMed Mentions:
62
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Toll-like receptors in liver fibrosis: cellular crosstalk and mechanisms. Front Physiol. 2012; 3:138.
Yang L, Seki E. PMID: 22661952; PMCID: PMC3357552.
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PubMed Mentions:
89
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Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes. Surgery. 2012 Nov; 152(5):869-78.
Abe Y, Uchinami H, Kudoh K, Nakagawa Y, Ise N, Watanabe G, Sato T, Seki E, Yamamoto Y. PMID: 22575885; PMCID: PMC4589249.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1310-21.
Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. PMID: 22442158; PMCID: PMC3378163.
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PubMed Mentions:
247 Fields:
Translation:
AnimalsCells
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Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol. 2012 Feb 01; 590(3):447-58.
Seki E, Schnabl B. PMID: 22124143; PMCID: PMC3379693.
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PubMed Mentions:
204 Fields:
Translation:
HumansAnimals
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L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 2011 Oct 07; 286(40):34800-8.
Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M. PMID: 21841000; PMCID: PMC3186417.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6.
Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. PMID: 21711427; PMCID: PMC3341613.
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PubMed Mentions:
24
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Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis. Hepatol Res. 2011 Jul; 41(7):597-610.
Seki E, Park E, Fujimoto J. PMID: 21696522; PMCID: PMC3754784.
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PubMed Mentions:
16
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Toll-like receptor signaling in liver diseases. Gastroenterol Res Pract. 2010; 2010:971270.
Szabo G, Billiar TR, Machida K, Crispe IN, Seki E. PMID: 21789039; PMCID: PMC3123973.
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PubMed Mentions:
8
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The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41.
Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA. PMID: 21384410; PMCID: PMC3082608.
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PubMed Mentions:
108 Fields:
Translation:
AnimalsCells
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Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18.
Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. PMID: 21463341; PMCID: PMC3131439.
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PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
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Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25.
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. PMID: 21252049; PMCID: PMC3774265.
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PubMed Mentions:
117 Fields:
Translation:
HumansCells
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Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847.
Miura K, Seki E, Ohnishi H, Brenner DA. PMID: 21274430; PMCID: PMC3026974.
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PubMed Mentions:
70
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Mutation of the 5'-untranslated region stem-loop structure inhibits α1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619.
Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner DA. PMID: 21193410; PMCID: PMC3048743.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44.
Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M. PMID: 21163859; PMCID: PMC3058702.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30.
De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA. PMID: 20690191; PMCID: PMC2947612.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400.
Aoyama T, Inokuchi S, Brenner DA, Seki E. PMID: 20683935; PMCID: PMC2947579.
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PubMed Mentions:
96 Fields:
Translation:
AnimalsCells
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Toll-like receptor signaling and liver fibrosis. Gastroenterol Res Pract. 2010; 2010.
Aoyama T, Paik YH, Seki E. PMID: 20706677; PMCID: PMC2913673.
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PubMed Mentions:
70
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Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7.
Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. PMID: 20347818; PMCID: PMC4631262.
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PubMed Mentions:
371 Fields:
Translation:
AnimalsCells
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Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology. 2010 Jan; 51(1):237-45.
Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M. PMID: 19821528.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9.
Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. PMID: 20080763; PMCID: PMC2818947.
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PubMed Mentions:
158 Fields:
Translation:
AnimalsCells
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Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38.
Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. PMID: 19650157; PMCID: PMC4734904.
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PubMed Mentions:
62 Fields:
Translation:
AnimalsCells
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Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24.
Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97.
Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. PMID: 19441102; PMCID: PMC2705470.
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PubMed Mentions:
205 Fields:
Translation:
Animals
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CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70.
Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. PMID: 19603542; PMCID: PMC2701864.
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PubMed Mentions:
231 Fields:
Translation:
HumansAnimalsCells
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c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5.
Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. PMID: 19549522; PMCID: PMC2757473.
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PubMed Mentions:
98 Fields:
Translation:
AnimalsCells
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Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53.
Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. PMID: 19171902; PMCID: PMC2635765.
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PubMed Mentions:
137 Fields:
Translation:
HumansAnimalsCells
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Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26.
De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. PMID: 19025999.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38.
Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. PMID: 18823985.
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PubMed Mentions:
123 Fields:
Translation:
HumansAnimalsCells
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Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35.
Seki E, Brenner DA. PMID: 18506843.
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PubMed Mentions:
289 Fields:
Translation:
HumansAnimalsCells
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Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings. J Hepatol. 2008 Feb; 48(2):237-45.
Seki E, Kondo Y, Iimuro Y, Naka T, Son G, Kishimoto T, Fujimoto J, Tsutsui H, Nakanishi K. PMID: 18068850.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52.
Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. PMID: 17668872.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32.
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. PMID: 17952090.
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PubMed Mentions:
927 Fields:
Translation:
AnimalsCells
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Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Sep; 293(3):G631-9.
Son G, Iimuro Y, Seki E, Hirano T, Kaneda Y, Fujimoto J. PMID: 17640975.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Role of innate immune response in liver regeneration. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S57-8.
Iimuro Y, Seki E, Son G, Tsutsui H, Nakanishi K, Fujimoto J. PMID: 17567467.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9.
Seki E, Brenner DA. PMID: 17566588; PMCID: PMC2739234.
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PubMed Mentions:
8 Fields:
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Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46.
De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. PMID: 17484886.
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PubMed Mentions:
213 Fields:
Translation:
AnimalsCells
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Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47.
Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. PMID: 17032415.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9.
Uchinami H, Seki E, Brenner DA, D'Armiento J. PMID: 16871591.
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PubMed Mentions:
85 Fields:
Translation:
AnimalsCells
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Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. J Hepatol. 2006 Nov; 45(5):688-95.
Son G, Hirano T, Seki E, Iimuro Y, Nukiwa T, Matsumoto K, Nakamura T, Fujimoto J. PMID: 16839638.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900.
Schwabe RF, Seki E, Brenner DA. PMID: 16697751.
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PubMed Mentions:
159 Fields:
Translation:
HumansCells
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Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72.
Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. PMID: 16697719.
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PubMed Mentions:
103 Fields:
Translation:
Humans
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Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J Biol Chem. 2006 Apr 14; 281(15):10431-8.
Siegmund SV, Seki E, Osawa Y, Uchinami H, Cravatt BF, Schwabe RF. PMID: 16418162.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology. 2005 Mar; 41(3):443-50.
Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J. PMID: 15723296.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells. 2004 Nov; 9(11):1055-67.
Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S. PMID: 15507117.
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PubMed Mentions:
79 Fields:
Translation:
AnimalsCells
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Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol. 2004 Jun; 16(6):787-98.
Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L, Nakanishi K. PMID: 15096477.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Roles of caspase-1 in Listeria infection in mice. Int Immunol. 2004 Feb; 16(2):335-43.
Tsuji NM, Tsutsui H, Seki E, Kuida K, Okamura H, Nakanishi K, Flavell RA. PMID: 14734619.
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PubMed Mentions:
67 Fields:
Translation:
AnimalsCells
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Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology. 2003 Aug; 38(2):335-44.
Ogushi I, Iimuro Y, Seki E, Son G, Hirano T, Hada T, Tsutsui H, Nakanishi K, Morishita R, Kaneda Y, Fujimoto J. PMID: 12883477.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 2003 Aug; 94(8):679-85.
Kato T, Miyamoto M, Date T, Yasui K, Taya C, Yonekawa H, Ohue C, Yagi S, Seki E, Hirano T, Fujimoto J, Shirai T, Wakita T. PMID: 12901792; PMCID: PMC11160254.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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SOCS-1 participates in negative regulation of LPS responses. Immunity. 2002 Nov; 17(5):677-87.
Nakagawa R, Naka T, Tsutsui H, Fujimoto M, Kimura A, Abe T, Seki E, Sato S, Takeuchi O, Takeda K, Akira S, Yamanishi K, Kawase I, Nakanishi K, Kishimoto T. PMID: 12433373.
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PubMed Mentions:
212 Fields:
Translation:
AnimalsCells
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Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice. J Immunol. 2002 Oct 01; 169(7):3863-8.
Seki E, Tsutsui H, Tsuji NM, Hayashi N, Adachi K, Nakano H, Futatsugi-Yumikura S, Takeuchi O, Hoshino K, Akira S, Fujimoto J, Nakanishi K. PMID: 12244183.
View in:
PubMed Mentions:
107 Fields:
Translation:
AnimalsCells