Ekihiro Seki

Title(s)Professor-in-Residence, Medicine
SchoolMedicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Unveiling the cancer risk nexus of the steatotic liver. Trends Endocrinol Metab. 2024 Mar 25. Kim J, Seki E. PMID: 38531699.
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    2. S-Adenosylmethionine Negatively Regulates the Mitochondrial Respiratory Chain Repressor MCJ in the Liver. Int J Biol Sci. 2024; 20(4):1218-1237. Barbier-Torres L, Chhimwal J, Kim SY, Ramani K, Robinson A, Yang H, Van Eyk J, Liangpunsakul S, Seki E, Mato JM, Lu SC. PMID: 38385082; PMCID: PMC10878152.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis. J Hepatol. 2024 Mar; 80(3):443-453. Fan W, Cao D, Yang B, Wang J, Li X, Kitka D, Li TWH, You S, Shiao S, Gangi A, Posadas E, Di Vizio D, Tomasi ML, Seki E, Mato JM, Yang H, Lu SC. PMID: 38086446; PMCID: PMC10922446.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and Limitations. Cell Mol Gastroenterol Hepatol. 2023; 16(3):355-367. Lee YS, Seki E. PMID: 37270060; PMCID: PMC10444957.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    5. Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment. Cell Metab. 2023 07 11; 35(7):1209-1226.e13. Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang YM, Matsuda M, Reolizo L, Tsuchiya T, Billet S, Gangi A, Noureddin M, Falk BA, Kim S, Fan W, Tighiouart M, You S, Lewis MS, Pandol SJ, Di Vizio D, Merchant A, Posadas EM, Bhowmick NA, Lu SC, Seki E. PMID: 37172577; PMCID: PMC10524732.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    6. Correction: Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2023 Apr 18; 12. Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E. PMID: 37071069; PMCID: PMC10112883.
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    7. Hyaluronan in liver fibrosis: basic mechanisms, clinical implications, and therapeutic targets. Hepatol Commun. 2023 04 01; 7(4). Kim J, Seki E. PMID: 36930869; PMCID: PMC10027054.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. FAP: Not Just a Biomarker but Druggable Target in Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2023; 15(4):1018-1019. Kim J, Seki E. PMID: 36681094; PMCID: PMC10040959.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1. J Hepatol. 2023 04; 78(4):805-819. Tao L, Yang G, Sun T, Zhu C, Yu H, Cheng Y, Yang Z, Xu M, Jiang Y, Zhang W, Wang Z, Ma W, Wu L, Xue D, Wang D, Yang W, Zhao Y, Horsefield S, Kobe B, Zhang Z, Tang Z, Li Q, Zhai Q, Dooley S, Seki E, Liu P, Xu J, Chen H, Liu C. PMID: 36669703.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Experimental Workflow for Preclinical Studies of Human Antifibrotic Therapies. Methods Mol Biol. 2023; 2669:285-306. Reolizo L, Matsuda M, Seki E. PMID: 37247068.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Breast cancer liver metastasis: Pathogenesis and clinical implications. Front Oncol. 2022; 12:1043771. Liu C, Mohan SC, Wei J, Seki E, Liu M, Basho R, Giuliano AE, Zhao Y, Cui X. PMID: 36387238; PMCID: PMC9641291.
      View in: PubMed   Mentions: 4  
    12. Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models. Elife. 2022 10 04; 11. Ramani K, Mavila N, Abeynayake A, Tomasi ML, Wang J, Matsuda M, Seki E. PMID: 36193675; PMCID: PMC9531947.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B. Can J Gastroenterol Hepatol. 2022; 2022:1048104. Yang G, Zhuang L, Sun T, Yeo YH, Tao L, Zhang W, Ma W, Wu L, Yang Z, Yang Y, Xue D, Zhang J, Feng R, Matthias P E, Dooley S, Seki E, Liu P, Liu C. PMID: 35855954; PMCID: PMC9288342.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Hyaluronan synthase 2, a target of miR-200c, promotes carbon tetrachloride-induced acute and chronic liver inflammation via regulation of CCL3 and CCL4. Exp Mol Med. 2022 06; 54(6):739-752. Kim SM, Song GY, Shim A, Lee JH, Eom CB, Liu C, Yang YM, Seki E. PMID: 35662287; PMCID: PMC9256637.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease. Nat Commun. 2022 01 28; 13(1):557. Barbier-Torres L, Murray B, Yang JW, Wang J, Matsuda M, Robinson A, Binek A, Fan W, Fernández-Ramos D, Lopitz-Otsoa F, Luque-Urbano M, Millet O, Mavila N, Peng H, Ramani K, Gottlieb R, Sun Z, Liangpunsakul S, Seki E, Van Eyk JE, Mato JM, Lu SC. PMID: 35091576; PMCID: PMC8799735.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Hepatocyte TGF-β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let-7b-5p. Hepatol Commun. 2022 06; 6(6):1301-1321. Zhao J, Hu L, Gui W, Xiao L, Wang W, Xia J, Fan H, Li Z, Zhu Q, Hou X, Chu H, Seki E, Yang L. PMID: 35018737; PMCID: PMC9134819.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. TAK1: A Molecular Link Between Liver Inflammation, Fibrosis, Steatosis, and Carcinogenesis. Front Cell Dev Biol. 2021; 9:734749. Wang W, Gao W, Zhu Q, Alasbahi A, Seki E, Yang L. PMID: 34722513; PMCID: PMC8551703.
      View in: PubMed   Mentions: 8  
    18. An Intestine-Derived HDL as a Novel Regulator of the Activity of Gut-Derived LPS: Ushering in a New Era of Research on the Gut-Liver Axis. Gastroenterology. 2022 02; 162(2):651-652. Kim J, Seki E. PMID: 34571025; PMCID: PMC8792181.
      View in: PubMed   Mentions: 1     Fields:    
    19. Crossing the Rubicon: Adipose Tissue Autophagy Breaks Out NAFLD. Cell Mol Gastroenterol Hepatol. 2021; 12(5):1877-1878. Kim J, Seki E. PMID: 34461065; PMCID: PMC8591194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans. Oncogene. 2021 09; 40(39):5866-5879. Lu L, Zhang J, Fan W, Li Y, Wang J, Li TWH, Barbier-Torres L, Mato JM, Liu T, Seki E, Matsuda M, Tomasi ML, Bhowmick NA, Yang H, Lu SC. PMID: 34349244; PMCID: PMC9611740.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    21. Modeling alcohol-associated liver disease in a human Liver-Chip. Cell Rep. 2021 07 20; 36(3):109393. Nawroth JC, Petropolis DB, Manatakis DV, Maulana TI, Burchett G, Schlünder K, Witt A, Shukla A, Kodella K, Ronxhi J, Kulkarni G, Hamilton G, Seki E, Lu S, Karalis KC. PMID: 34289365; PMCID: PMC8342038.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    22. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 Jun 14; 39(6):883. Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. PMID: 34129825; PMCID: PMC8532387.
      View in: PubMed   Mentions: 22     Fields:    
    23. Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 2021 06 01; 131(11). Bhattacharjee S, Hamberger F, Ravichandra A, Miller M, Nair A, Affo S, Filliol A, Chin L, Savage TM, Yin D, Wirsik NM, Mehal A, Arpaia N, Seki E, Mack M, Zhu D, Sims PA, Kalluri R, Stanger BZ, Olive KP, Schmidt T, Wells RG, Mederacke I, Schwabe RF. PMID: 33905375; PMCID: PMC8159701.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    24. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 06 14; 39(6):866-882.e11. Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. PMID: 33930309; PMCID: PMC8241235.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    25. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, et al. PMID: 33634751; PMCID: PMC7996087.
      View in: PubMed   Mentions: 870     Fields:    Translation:HumansAnimalsCells
    26. Global Spread of a Local Fire: Transmission of Endoplasmic Reticulum Stress via Connexin 43. Cell Metab. 2021 02 02; 33(2):229-230. Yang YM, Seki E. PMID: 33535096; PMCID: PMC8407036.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    27. Inhibition of hyaluronan synthesis by 4-methylumbelliferone ameliorates non-alcoholic steatohepatitis in choline-deficient L-amino acid-defined diet-induced murine model. Arch Pharm Res. 2021 Feb; 44(2):230-240. Yang YM, Wang Z, Matsuda M, Seki E. PMID: 33486695; PMCID: PMC8407017.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    28. Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E. PMID: 33443222; PMCID: PMC7817133.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    29. Increase in Alcoholic Hepatitis as an Etiology for Liver Transplantation in the United States: A 2004-2018 Analysis. Transplant Direct. 2020 Nov; 6(11):e612. Noureddin N, Yang JD, Alkhouri N, Noreen SM, Toll AE, Todo T, Ayoub W, Kuo A, Voidonikolas G, Kotler HG, Pelphrey MD, Durand BJ, Kosari K, Brennan TV, Kim I, Klein AS, Seki E, Nissen NN, Lu SC, Sundaram V, Noureddin M. PMID: 33134488; PMCID: PMC7546885.
      View in: PubMed   Mentions: 1  
    30. Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer. Hepatology. 2020 11; 72(5):1682-1700. Li Y, Lu L, Tu J, Zhang J, Xiong T, Fan W, Wang J, Li M, Chen Y, Steggerda J, Peng H, Chen Y, Li TWH, Zhou ZG, Mato JM, Seki E, Liu T, Yang H, Lu SC. PMID: 32080887; PMCID: PMC7442711.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    31. Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation. Front Physiol. 2020; 11:950. Wang Q, Wang Z, Xu M, Tu W, Hsin IF, Stotland A, Kim JH, Liu P, Naiki M, Gottlieb RA, Seki E. PMID: 32848877; PMCID: PMC7424056.
      View in: PubMed   Mentions: 2  
    32. The liver fibrosis niche: Novel insights into the interplay between fibrosis-composing mesenchymal cells, immune cells, endothelial cells, and extracellular matrix. Food Chem Toxicol. 2020 Sep; 143:111556. Matsuda M, Seki E. PMID: 32640349; PMCID: PMC7484466.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    33. Hepatic Stellate Cell-Macrophage Crosstalk in Liver Fibrosis and Carcinogenesis. Semin Liver Dis. 2020 Aug; 40(3):307-320. Matsuda M, Seki E. PMID: 32242330; PMCID: PMC7484001.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    34. Kupffer Cell TLR2/3 Signaling: A Pathway for EGCG Amelioration of Ethanol-Induced Hepatic Injury. Cell Mol Gastroenterol Hepatol. 2020; 9(1):187-188. Czech TY, Seki E. PMID: 31669157; PMCID: PMC6926269.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. J Biol Chem. 2019 08 16; 294(33):12359-12369. Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E. PMID: 31235522; PMCID: PMC6699832.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    36. Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Sci Transl Med. 2019 06 12; 11(496). Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E. PMID: 31189722; PMCID: PMC6589184.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    37. Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. Gut. 2019 12; 68(12):2214-2227. Tao L, Ma W, Wu L, Xu M, Yang Y, Zhang W, Sha W, Li H, Xu J, Feng R, Xue D, Zhang J, Dooley S, Seki E, Liu P, Liu C. PMID: 31171625; PMCID: PMC6842044.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    38. NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 11; 70(5):1582-1599. Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. PMID: 31044438; PMCID: PMC6819206.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    39. MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment. Cell Death Dis. 2019 02 11; 10(2):120. Wang P, Song X, Utpatel K, Shang R, Yang YM, Xu M, Zhang J, Che L, Gordan J, Cigliano A, Seki E, Evert M, Calvisi DF, Hu X, Chen X. PMID: 30741922; PMCID: PMC6370758.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    40. Intestinal Lipolysis Mitigates Nonalcoholic Fatty Liver Disease: New Roles for Carboxylesterase 2c in the Intestine. Hepatol Commun. 2019 Feb; 3(2):177-179. Pimienta M, Beletsky A, Seki E. PMID: 30766955; PMCID: PMC6357825.
      View in: PubMed   Mentions:    Fields:    
    41. Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets. Semin Liver Dis. 2019 02; 39(1):26-42. Yang YM, Kim SY, Seki E. PMID: 30809789; PMCID: PMC6616367.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansCells
    42. Alcoholic liver disease: A current molecular and clinical perspective. Liver Res. 2018 Dec; 2(4):161-172. Ohashi K, Pimienta M, Seki E. PMID: 31214376; PMCID: PMC6581514.
      View in: PubMed   Mentions: 34  
    43. The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. J Biol Chem. 2019 02 08; 294(6):1984-1996. Yang JW, Murray B, Barbier-Torres L, Liu T, Liu Z, Yang H, Fan W, Wang J, Li Y, Seki E, Mato JM, Lu SC. PMID: 30523154; PMCID: PMC6369293.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    44. Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest. 2018 12 03; 128(12):5587-5602. Kim TH, Yang YM, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. PMID: 30300140; PMCID: PMC6264648.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    45. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):E9879-E9888. Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. PMID: 30287485; PMCID: PMC6196518.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    46. Nuclear Receptors: Opening Up New Avenues of Pediatric Fatty Liver Research. Hepatol Commun. 2018 Oct; 2(10):1157-1159. Pandyarajan V, Seki E. PMID: 30288469; PMCID: PMC6167071.
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    47. MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis. Arch Toxicol. 2018 09; 92(9):2935-2946. Tao L, Xue D, Shen D, Ma W, Zhang J, Wang X, Zhang W, Wu L, Pan K, Yang Y, Nwosu ZC, Dooley S, Seki E, Liu C. PMID: 30097701; PMCID: PMC6590087.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    48. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 08; 560(7717):198-203. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. PMID: 30046112; PMCID: PMC6329306.
      View in: PubMed   Mentions: 440     Fields:    Translation:AnimalsCells
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    104. Liver epithelial cells proliferate under hypoxia and protect the liver from ischemic injury via expression of HIF-1 alpha target genes. Surgery. 2012 Nov; 152(5):869-78. Abe Y, Uchinami H, Kudoh K, Nakagawa Y, Ise N, Watanabe G, Sato T, Seki E, Yamamoto Y. PMID: 22575885; PMCID: PMC4589249.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    105. Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1310-21. Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. PMID: 22442158; PMCID: PMC3378163.
      View in: PubMed   Mentions: 247     Fields:    Translation:AnimalsCells
    106. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. J Physiol. 2012 Feb 01; 590(3):447-58. Seki E, Schnabl B. PMID: 22124143; PMCID: PMC3379693.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansAnimals
    107. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 2011 Oct 07; 286(40):34800-8. Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, Ito H, Suetsugu A, Nagaki M, Moriwaki H, Saito K, Seishima M. PMID: 21841000; PMCID: PMC3186417.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    108. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Hepatol Res. 2011 Jul; 41(7):683-6. Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y. PMID: 21711427; PMCID: PMC3341613.
      View in: PubMed   Mentions: 23  
    109. Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis. Hepatol Res. 2011 Jul; 41(7):597-610. Seki E, Park E, Fujimoto J. PMID: 21696522; PMCID: PMC3754784.
      View in: PubMed   Mentions: 13  
    110. Toll-like receptor signaling in liver diseases. Gastroenterol Res Pract. 2010; 2010:971270. Szabo G, Billiar TR, Machida K, Crispe IN, Seki E. PMID: 21789039; PMCID: PMC3123973.
      View in: PubMed   Mentions: 7  
    111. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology. 2011 May; 53(5):1730-41. Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA. PMID: 21384410; PMCID: PMC3082608.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    112. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. PMID: 21463341; PMCID: PMC3131439.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    113. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. PMID: 21252049; PMCID: PMC3774265.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansCells
    114. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. Gastroenterol Res Pract. 2010; 2010:362847. Miura K, Seki E, Ohnishi H, Brenner DA. PMID: 21274430; PMCID: PMC3026974.
      View in: PubMed   Mentions: 71  
    115. Mutation of the 5'-untranslated region stem-loop structure inhibits α1(I) collagen expression in vivo. J Biol Chem. 2011 Mar 11; 286(10):8609-8619. Parsons CJ, Stefanovic B, Seki E, Aoyama T, Latour AM, Marzluff WF, Rippe RA, Brenner DA. PMID: 21193410; PMCID: PMC3048743.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    116. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. FASEB J. 2011 Apr; 25(4):1133-44. Osawa Y, Seki E, Kodama Y, Suetsugu A, Miura K, Adachi M, Ito H, Shiratori Y, Banno Y, Olefsky JM, Nagaki M, Moriwaki H, Brenner DA, Seishima M. PMID: 21163859; PMCID: PMC3058702.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    117. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010 Oct; 52(4):1420-30. De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, Torozzi L, Miyai K, Benedetti A, Schwabe RF, Brenner DA. PMID: 20690191; PMCID: PMC2947612.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    118. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. 2010 Oct; 52(4):1390-400. Aoyama T, Inokuchi S, Brenner DA, Seki E. PMID: 20683935; PMCID: PMC2947579.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    119. Toll-like receptor signaling and liver fibrosis. Gastroenterol Res Pract. 2010; 2010. Aoyama T, Paik YH, Seki E. PMID: 20706677; PMCID: PMC2913673.
      View in: PubMed   Mentions: 68  
    120. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology. 2010 Jul; 139(1):323-34.e7. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H, Olefsky JM, Brenner DA, Seki E. PMID: 20347818; PMCID: PMC4631262.
      View in: PubMed   Mentions: 370     Fields:    Translation:AnimalsCells
    121. Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice. Hepatology. 2010 Jan; 51(1):237-45. Osawa Y, Seki E, Adachi M, Suetsugu A, Ito H, Moriwaki H, Seishima M, Nagaki M. PMID: 19821528.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    122. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):844-9. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. PMID: 20080763; PMCID: PMC2818947.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    123. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 2009 Sep; 50(3):929-38. Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. PMID: 19650157; PMCID: PMC4734904.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    124. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Integr Biol (Camb). 2009 Sep; 1(8-9):513-24. Brafman DA, de Minicis S, Seki E, Shah KD, Teng D, Brenner D, Willert K, Chien S. PMID: 20023766.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    125. CCR2 promotes hepatic fibrosis in mice. Hepatology. 2009 Jul; 50(1):185-97. Seki E, de Minicis S, Inokuchi S, Taura K, Miyai K, van Rooijen N, Schwabe RF, Brenner DA. PMID: 19441102; PMCID: PMC2705470.
      View in: PubMed   Mentions: 204     Fields:    Translation:Animals
    126. CCR1 and CCR5 promote hepatic fibrosis in mice. J Clin Invest. 2009 Jul; 119(7):1858-70. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. PMID: 19603542; PMCID: PMC2701864.
      View in: PubMed   Mentions: 230     Fields:    Translation:HumansAnimalsCells
    127. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Gastroenterology. 2009 Oct; 137(4):1467-1477.e5. Kodama Y, Kisseleva T, Iwaisako K, Miura K, Taura K, De Minicis S, Osterreicher CH, Schnabl B, Seki E, Brenner DA. PMID: 19549522; PMCID: PMC2757473.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    128. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. PMID: 19171902; PMCID: PMC2635765.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    129. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008 Dec; 48(6):2016-26. De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. PMID: 19025999.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    130. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Gastroenterology. 2008 Nov; 135(5):1729-38. Taura K, De Minicis S, Seki E, Hatano E, Iwaisako K, Osterreicher CH, Kodama Y, Miura K, Ikai I, Uemoto S, Brenner DA. PMID: 18823985.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    131. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008 Jul; 48(1):322-35. Seki E, Brenner DA. PMID: 18506843.
      View in: PubMed   Mentions: 286     Fields:    Translation:HumansAnimalsCells
    132. Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings. J Hepatol. 2008 Feb; 48(2):237-45. Seki E, Kondo Y, Iimuro Y, Naka T, Son G, Kishimoto T, Fujimoto J, Tsutsui H, Nakanishi K. PMID: 18068850.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    133. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Hepatology. 2007 Nov; 46(5):1443-52. Mencin A, Seki E, Osawa Y, Kodama Y, De Minicis S, Knowles M, Brenner DA. PMID: 17668872.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    134. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007 Nov; 13(11):1324-32. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. PMID: 17952090.
      View in: PubMed   Mentions: 908     Fields:    Translation:AnimalsCells
    135. Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007 Sep; 293(3):G631-9. Son G, Iimuro Y, Seki E, Hirano T, Kaneda Y, Fujimoto J. PMID: 17640975.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    136. Role of innate immune response in liver regeneration. J Gastroenterol Hepatol. 2007 Jun; 22 Suppl 1:S57-8. Iimuro Y, Seki E, Son G, Tsutsui H, Nakanishi K, Fujimoto J. PMID: 17567467.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    137. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? J Hepatol. 2007 Aug; 47(2):307-9. Seki E, Brenner DA. PMID: 17566588; PMCID: PMC2739234.
      View in: PubMed   Mentions: 8     Fields:    
    138. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Gastroenterology. 2007 May; 132(5):1937-46. De Minicis S, Seki E, Uchinami H, Kluwe J, Zhang Y, Brenner DA, Schwabe RF. PMID: 17484886.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    139. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Liver Int. 2006 Nov; 26(9):1138-47. Osawa Y, Seki E, Adachi M, Taura K, Kodama Y, Siegmund SV, Schwabe RF, Brenner DA. PMID: 17032415.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    140. Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis. Hepatology. 2006 Aug; 44(2):420-9. Uchinami H, Seki E, Brenner DA, D'Armiento J. PMID: 16871591.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    141. Blockage of HGF/c-Met system by gene therapy (adenovirus-mediated NK4 gene) suppresses hepatocellular carcinoma in mice. J Hepatol. 2006 Nov; 45(5):688-95. Son G, Hirano T, Seki E, Iimuro Y, Nukiwa T, Matsumoto K, Nakamura T, Fujimoto J. PMID: 16839638.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    142. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. 2006 May; 130(6):1564-72. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N, Seki E, Brenner D, Korenblat K, McCrea J. PMID: 16697719.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    143. Toll-like receptor signaling in the liver. Gastroenterology. 2006 May; 130(6):1886-900. Schwabe RF, Seki E, Brenner DA. PMID: 16697751.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansCells
    144. Fatty acid amide hydrolase determines anandamide-induced cell death in the liver. J Biol Chem. 2006 Apr 14; 281(15):10431-8. Siegmund SV, Seki E, Osawa Y, Uchinami H, Cravatt BF, Schwabe RF. PMID: 16418162.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    145. Contribution of Toll-like receptor/myeloid differentiation factor 88 signaling to murine liver regeneration. Hepatology. 2005 Mar; 41(3):443-50. Seki E, Tsutsui H, Iimuro Y, Naka T, Son G, Akira S, Kishimoto T, Nakanishi K, Fujimoto J. PMID: 15723296.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    146. ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules. Genes Cells. 2004 Nov; 9(11):1055-67. Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S. PMID: 15507117.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    147. Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int Immunol. 2004 Jun; 16(6):787-98. Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L, Nakanishi K. PMID: 15096477.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    148. Roles of caspase-1 in Listeria infection in mice. Int Immunol. 2004 Feb; 16(2):335-43. Tsuji NM, Tsutsui H, Seki E, Kuida K, Okamura H, Nakanishi K, Flavell RA. PMID: 14734619.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    149. Repeated hepatocyte injury promotes hepatic tumorigenesis in hepatitis C virus transgenic mice. Cancer Sci. 2003 Aug; 94(8):679-85. Kato T, Miyamoto M, Date T, Yasui K, Taya C, Yonekawa H, Ohue C, Yagi S, Seki E, Hirano T, Fujimoto J, Shirai T, Wakita T. PMID: 12901792.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    150. Nuclear factor kappa B decoy oligodeoxynucleotides prevent endotoxin-induced fatal liver failure in a murine model. Hepatology. 2003 Aug; 38(2):335-44. Ogushi I, Iimuro Y, Seki E, Son G, Hirano T, Hada T, Tsutsui H, Nakanishi K, Morishita R, Kaneda Y, Fujimoto J. PMID: 12883477.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
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