Fayyaz Sutterwala

Title(s)Professor, Medicine
SchoolMedicine
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    1. A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation. Sci Signal. 2021 Aug 03; 14(694). Ernst O, Sun J, Lin B, Banoth B, Dorrington MG, Liang J, Schwarz B, Stromberg KA, Katz S, Vayttaden SJ, Bradfield CJ, Slepushkina N, Rice CM, Buehler E, Khillan JS, McVicar DW, Bosio CM, Bryant CE, Sutterwala FS, Martin SE, Lal-Nag M, Fraser IDC. PMID: 34344832.
      View in: PubMed   Mentions:    Fields:    
    2. Recruitment of pro-IL-1a to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M. PMID: 33361152.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Hepatology. 2019 11; 70(5):1582-1599. Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. PMID: 31044438.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    4. Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A. PLoS Negl Trop Dis. 2019 05; 13(5):e0007247. Borbón TY, Scorza BM, Clay GM, Lima Nobre de Queiroz F, Sariol AJ, Bowen JL, Chen Y, Zhanbolat B, Parlet CP, Valadares DG, Cassel SL, Nauseef WM, Horswill AR, Sutterwala FS, Wilson ME. PMID: 31107882.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression. J Clin Invest. 2019 04 30; 129(7):2888-2897. Hornick EE, Dagvadorj J, Zacharias ZR, Miller AM, Langlois RA, Chen P, Legge KL, Bishop GA, Sutterwala FS, Cassel SL. PMID: 31038471.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 2019 03; 38(13):2351-2363. Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. PMID: 30518876.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    7. NLRP12: The Monarch of the Gut. Cell Host Microbe. 2018 09 12; 24(3):326-328. Sadeghi H, Devkota S, Sutterwala FS. PMID: 30212643.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. TIMP-1 Promotes the Immune Response in Influenza-Induced Acute Lung Injury. Lung. 2018 12; 196(6):737-743. Allen JR, Ge L, Huang Y, Brauer R, Parimon T, Cassel SL, Sutterwala FS, Chen P. PMID: 30167842.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Inflammasomes in livestock and wildlife: Insights into the intersection of pathogens and natural host species. Vet Immunol Immunopathol. 2018 Jul; 201:49-56. Vrentas CE, Schaut RG, Boggiatto PM, Olsen SC, Sutterwala FS, Moayeri M. PMID: 29914682.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming. J Immunol. 2018 05 01; 200(9):3047-3052. Elliott EI, Miller AN, Banoth B, Iyer SS, Stotland A, Weiss JP, Gottlieb RA, Sutterwala FS, Cassel SL. PMID: 29602772.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    11. Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. J Immunol. 2018 02 01; 200(3):1188-1197. Hornick EE, Banoth B, Miller AM, Zacharias ZR, Jain N, Wilson ME, Gibson-Corley KN, Legge KL, Bishop GA, Sutterwala FS, Cassel SL. PMID: 29282312.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Yellow Fever Virus, but Not Zika Virus or Dengue Virus, Inhibits T-Cell Receptor-Mediated T-Cell Function by an RNA-Based Mechanism. J Infect Dis. 2017 11 27; 216(9):1164-1175. McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman JC, Xiang J. PMID: 28968905.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Confounding role of tumor necrosis factor in cryopyrin-associated periodic syndromes. J Clin Invest. 2017 12 01; 127(12):4235-4237. Banoth B, Sutterwala FS. PMID: 29130931.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis. J Immunol. 2017 10 15; 199(8):2823-2833. Clay GM, Valadares DG, Graff JW, Ulland TK, Davis RE, Scorza BM, Zhanbolat BS, Chen Y, Sutterwala FS, Wilson ME. PMID: 28931602.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    15. Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):E5444-E5453. Vijay R, Fehr AR, Janowski AM, Athmer J, Wheeler DL, Grunewald M, Sompallae R, Kurup SP, Meyerholz DK, Sutterwala FS, Narumiya S, Perlman S. PMID: 28630327.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. JCI Insight. 2017 02 09; 2(3):e88297. Sebag SC, Koval OM, Paschke JD, Winters CJ, Jaffer OA, Dworski R, Sutterwala FS, Anderson ME, Grumbach IM. PMID: 28194433.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide. Brain Behav Immun. 2017 May; 62:137-150. Zielinski MR, Gerashchenko D, Karpova SA, Konanki V, McCarley RW, Sutterwala FS, Strecker RE, Basheer R. PMID: 28109896.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun. 2016 10 25; 7:13180. Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS. PMID: 27779193.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun. 2016 10 06; 7:13007. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W. PMID: 27708283.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    20. Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy. PLoS One. 2016; 11(10):e0164135. Yuan F, Kolb R, Pandey G, Li W, Sun L, Liu F, Sutterwala FS, Liu Y, Zhang W. PMID: 27706238.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Nicotine Mediates CD161a+ Renal Macrophage Infiltration and Premature Hypertension in the Spontaneously Hypertensive Rat. Circ Res. 2016 Oct 28; 119(10):1101-1115. Harwani SC, Ratcliff J, Sutterwala FS, Ballas ZK, Meyerholz DK, Chapleau MW, Abboud FM. PMID: 27660287.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    22. NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. J Clin Invest. 2016 10 03; 126(10):3917-3928. Janowski AM, Colegio OR, Hornick EE, McNiff JM, Martin MD, Badovinac VP, Norian LA, Zhang W, Cassel SL, Sutterwala FS. PMID: 27617861.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016 08; 12(8):e1005803. Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH. PMID: 27482714.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    24. Obesity and cancer: inflammation bridges the two. Curr Opin Pharmacol. 2016 08; 29:77-89. Kolb R, Sutterwala FS, Zhang W. PMID: 27429211.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    25. The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infect Immun. 2016 06; 84(6):1796-1805. Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JHF. PMID: 27045038.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    26. Monocytes Take Their Own Path to IL-1ß. Immunity. 2016 Apr 19; 44(4):713-5. Elliott EI, Sutterwala FS. PMID: 27096310.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Complement-mediated 'bystander' damage initiates host NLRP3 inflammasome activation. J Cell Sci. 2016 05 01; 129(9):1928-39. Suresh R, Chandrasekaran P, Sutterwala FS, Mosser DM. PMID: 27006116.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. Immune Complexes Indirectly Suppress the Generation of Th17 Responses In Vivo. PLoS One. 2016; 11(3):e0151252. Ciraci C, Janczy JR, Jain N, Haasken S, Pecli E Silva C, Benjamim CF, Sadler JJ, Olivier AK, Iwakura Y, Shayakhmetov DM, Sutterwala FS, Cassel SL. PMID: 26978520.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Atypical Inflammasomes. Methods Mol Biol. 2016; 1417:45-62. Janowski AM, Sutterwala FS. PMID: 27221480.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    30. Correction: Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation. J Immunol. 2015 Dec 15; 195(12):5837-8. Scholz F, Naik S, Sutterwala FS, Kaplan DH. PMID: 26637662.
      View in: PubMed   Mentions:    Fields:    
    31. Corrigendum: NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2016 Feb 25; 530(7591):504. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. PMID: 26605525.
      View in: PubMed   Mentions: 3     Fields:    
    32. Langerhans Cells Suppress CD49a+ NK Cell-Mediated Skin Inflammation. J Immunol. 2015 Sep 01; 195(5):2335-42. Scholz F, Naik S, Sutterwala FS, Kaplan DH. PMID: 26209621.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    33. Activation of autophagy and nucleotide-binding domain leucine-rich repeat-containing-like receptor family, pyrin domain-containing 3 inflammasome during Leishmania infantum-associated glomerulonephritis. Am J Pathol. 2015 Aug; 185(8):2105-17. Esch KJ, Schaut RG, Lamb IM, Clay G, Morais Lima ÁL, do Nascimento PR, Whitley EM, Jeronimo SM, Sutterwala FS, Haynes JS, Petersen CA. PMID: 26079813.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    34. Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev. 2015 May; 265(1):35-52. Elliott EI, Sutterwala FS. PMID: 25879282.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    35. Secretion of Flagellar Proteins by the Pseudomonas aeruginosa Type III Secretion-Injectisome System. J Bacteriol. 2015 Jun 15; 197(12):2003-11. Ince D, Sutterwala FS, Yahr TL. PMID: 25845843.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    36. Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3056-61. Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC. PMID: 25713392.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    37. Evasion of inflammasome activation by microbial pathogens. J Clin Invest. 2015 Feb; 125(2):469-77. Ulland TK, Ferguson PJ, Sutterwala FS. PMID: 25642707.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    38. Immune complexes inhibit IL-1 secretion and inflammasome activation. J Immunol. 2014 Nov 15; 193(10):5190-8. Janczy JR, Ciraci C, Haasken S, Iwakura Y, Olivier AK, Cassel SL, Sutterwala FS. PMID: 25320279.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    39. NLR proteins and parasitic disease. Immunol Res. 2014 Aug; 59(1-3):142-52. Clay GM, Sutterwala FS, Wilson ME. PMID: 24989828.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    40. Editorial: dialing down inflammation: LRRC33 regulates Toll-like receptor signaling. J Leukoc Biol. 2014 Jul; 96(1):4-6. Janowski AM, Sutterwala FS. PMID: 24982033.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    41. Catching fire: Candida albicans, macrophages, and pyroptosis. PLoS Pathog. 2014 Jun; 10(6):e1004139. Krysan DJ, Sutterwala FS, Wellington M. PMID: 24967821.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    42. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci. 2014 Jun; 1319:82-95. Sutterwala FS, Haasken S, Cassel SL. PMID: 24840700.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimals
    43. A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion. Am J Pathol. 2014 Jul; 184(7):2013-22. Bakker PJ, Butter LM, Claessen N, Teske GJ, Sutterwala FS, Florquin S, Leemans JC. PMID: 24823805.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    44. The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection. Infect Immun. 2014 Jun; 82(6):2553-64. Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH. PMID: 24686067.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    45. Inflammasomes in cancer: a double-edged sword. Protein Cell. 2014 Jan; 5(1):12-20. Kolb R, Liu GH, Janowski AM, Sutterwala FS, Zhang W. PMID: 24474192.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
    46. Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction. PLoS One. 2014; 9(1):e85775. Pulskens WP, Butter LM, Teske GJ, Claessen N, Dessing MC, Flavell RA, Sutterwala FS, Florquin S, Leemans JC. PMID: 24454932.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    47. Inflammasome-independent IL-1ß mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1072-7. Cassel SL, Janczy JR, Bing X, Wilson SP, Olivier AK, Otero JE, Iwakura Y, Shayakhmetov DM, Bassuk AG, Abu-Amer Y, Brogden KA, Burns TL, Sutterwala FS, Ferguson PJ. PMID: 24395802.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    48. Candida albicans triggers NLRP3-mediated pyroptosis in macrophages. Eukaryot Cell. 2014 Feb; 13(2):329-40. Wellington M, Koselny K, Sutterwala FS, Krysan DJ. PMID: 24376002.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    49. Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation. Kidney Int. 2014 May; 85(5):1112-22. Bakker PJ, Butter LM, Kors L, Teske GJ, Aten J, Sutterwala FS, Florquin S, Leemans JC. PMID: 24352154.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    50. Beneficial and Detrimental Roles of NLRs in Carcinogenesis. Front Immunol. 2013; 4:370. Janowski AM, Kolb R, Zhang W, Sutterwala FS. PMID: 24273542.
      View in: PubMed   Mentions: 17     Fields:    
    51. Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-ß and AIM2 inflammasome-dependent IL-1ß production via its ESX-1 secretion system. J Immunol. 2013 Oct 01; 191(7):3514-8. Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. PMID: 23997220.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    52. Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity. 2013 Aug 22; 39(2):311-323. Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS. PMID: 23954133.
      View in: PubMed   Mentions: 276     Fields:    Translation:HumansAnimalsCells
    53. Damage control: management of cellular stress by the NLRP3 inflammasome. Eur J Immunol. 2013 Aug; 43(8):2003-5. Haasken S, Sutterwala FS. PMID: 23928964.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    54. Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. J Biol Chem. 2013 Mar 15; 288(11):7481-7491. Jacobson LS, Lima H, Goldberg MF, Gocheva V, Tsiperson V, Sutterwala FS, Joyce JA, Gapp BV, Blomen VA, Chandran K, Brummelkamp TR, Diaz-Griffero F, Brojatsch J. PMID: 23297415.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    55. TRPM2 links oxidative stress to the NLRP3 inflammasome activation (P1268). J Immunol. 2013; 190. Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala F, Qiao L. PMID: 25221348.
      View in: PubMed   Mentions: 2     Fields:    
    56. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun. 2013; 4:1611. Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L. PMID: 23511475.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    57. Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Infect Immun. 2013 Jan; 81(1):201-8. Ulland TK, Janowski AM, Buchan BW, Faron M, Cassel SL, Jones BD, Sutterwala FS. PMID: 23115038.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    58. Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J Immunol. 2012 Nov 15; 189(10):4713-7. Joly S, Eisenbarth SC, Olivier AK, Williams A, Kaplan DH, Cassel SL, Flavell RA, Sutterwala FS. PMID: 23071280.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    59. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1ß and IL-18 secretion but not to pyroptosis. PLoS One. 2012; 7(7):e40722. Abdalla H, Srinivasan L, Shah S, Mayer-Barber KD, Sher A, Sutterwala FS, Briken V. PMID: 22911706.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    60. Control of innate and adaptive immunity by the inflammasome. Microbes Infect. 2012 Nov; 14(14):1263-70. Ciraci C, Janczy JR, Sutterwala FS, Cassel SL. PMID: 22841804.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    61. Anaplasma phagocytophilum dihydrolipoamide dehydrogenase 1 affects host-derived immunopathology during microbial colonization. Infect Immun. 2012 Sep; 80(9):3194-205. Chen G, Severo MS, Sakhon OS, Choy A, Herron MJ, Felsheim RF, Wiryawan H, Liao J, Johns JL, Munderloh UG, Sutterwala FS, Kotsyfakis M, Pedra JH. PMID: 22753375.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    62. Ventilator-induced lung injury is mediated by the NLRP3 inflammasome. Anesthesiology. 2012 May; 116(5):1104-15. Kuipers MT, Aslami H, Janczy JR, van der Sluijs KF, Vlaar AP, Wolthuis EK, Choi G, Roelofs JJ, Flavell RA, Sutterwala FS, Bresser P, Leemans JC, van der Poll T, Schultz MJ, Wieland CW. PMID: 22531249.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    63. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature. 2012 Apr 25; 484(7395):510-3. Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. PMID: 22538615.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    64. Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nat Commun. 2012 Mar 27; 3:755. Scharf B, Clement CC, Wu XX, Morozova K, Zanolini D, Follenzi A, Larocca JN, Levon K, Sutterwala FS, Rand J, Cobelli N, Purdue E, Hajjar KA, Santambrogio L. PMID: 22453828.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    65. Inhibitors of apoptosis proteins and IL-1ß: a tangled relationship. Immunity. 2012 Feb 24; 36(2):155-7. Ciraci C, Sutterwala FS. PMID: 22365658.
      View in: PubMed   Mentions: 1     Fields:    
    66. Sensing damage by the NLRP3 inflammasome. Immunol Rev. 2011 Sep; 243(1):152-62. Leemans JC, Cassel SL, Sutterwala FS. PMID: 21884174.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimals
    67. Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol. 2010 Oct 15; 185(8):4515-9. Arthur JC, Lich JD, Ye Z, Allen IC, Gris D, Wilson JE, Schneider M, Roney KE, O'Connor BP, Moore CB, Morrison A, Sutterwala FS, Bertin J, Koller BH, Liu Z, Ting JP. PMID: 20861349.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    68. Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence. J Immunol. 2010 Sep 01; 185(5):2670-4. Ulland TK, Buchan BW, Ketterer MR, Fernandes-Alnemri T, Meyerholz DK, Apicella MA, Alnemri ES, Jones BD, Nauseef WM, Sutterwala FS. PMID: 20679532.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    69. Fungal pathogen recognition by the NLRP3 inflammasome. Virulence. 2010 Jul-Aug; 1(4):276-80. Joly S, Sutterwala FS. PMID: 21178453.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    70. A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. . 2010 May 20; 7(5):376-87. Brodsky IE, Palm NW, Sadanand S, Ryndak MB, Sutterwala FS, Flavell RA, Bliska JB, Medzhitov R. PMID: 20478539.
      View in: PubMed   Mentions:
    71. Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol. 2010 Apr 01; 184(7):3326-30. Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A. PMID: 20200276.
      View in: PubMed   Mentions: 197     Fields:    Translation:AnimalsCells
    72. Sterile inflammatory responses mediated by the NLRP3 inflammasome. Eur J Immunol. 2010 Mar; 40(3):607-11. Cassel SL, Sutterwala FS. PMID: 20201012.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    73. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20388-93. Iyer SS, Pulskens WP, Sadler JJ, Butter LM, Teske GJ, Ulland TK, Eisenbarth SC, Florquin S, Flavell RA, Leemans JC, Sutterwala FS. PMID: 19918053.
      View in: PubMed   Mentions: 279     Fields:    Translation:AnimalsCells
    74. Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog. 2009 Aug; 5(8):e1000559. Shio MT, Tiemi Shio M, Eisenbarth SC, Savaria M, Vinet AF, Bellemare MJ, Harder KW, Sutterwala FS, Bohle DS, Descoteaux A, Flavell RA, Olivier M. PMID: 19696895.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    75. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol. 2009 Sep 15; 183(6):3578-81. Joly S, Ma N, Sadler JJ, Soll DR, Cassel SL, Sutterwala FS. PMID: 19684085.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    76. The NLRP3 inflammasome: a sensor of immune danger signals. Semin Immunol. 2009 Aug; 21(4):194-8. Cassel SL, Joly S, Sutterwala FS. PMID: 19501527.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    77. Inflammasome-mediated regulation of hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1248-57. Watanabe A, Sohail MA, Gomes DA, Hashmi A, Nagata J, Sutterwala FS, Mahmood S, Jhandier MN, Shi Y, Flavell RA, Mehal WZ. PMID: 19359429.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    78. Sensing pathogens and danger signals by the inflammasome. Curr Opin Immunol. 2009 Feb; 21(1):10-6. Pedra JH, Cassel SL, Sutterwala FS. PMID: 19223160.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    79. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest. 2009 Feb; 119(2):305-14. Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA, Mehal WZ. PMID: 19164858.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansAnimalsCells
    80. NLRC4/IPAF: a CARD carrying member of the NLR family. Clin Immunol. 2009 Jan; 130(1):2-6. Sutterwala FS, Flavell RA. PMID: 18819842.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    81. The Nalp3 inflammasome is essential for the development of silicosis. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9035-40. Cassel SL, Eisenbarth SC, Iyer SS, Sadler JJ, Colegio OR, Tephly LA, Carter AB, Rothman PB, Flavell RA, Sutterwala FS. PMID: 18577586.
      View in: PubMed   Mentions: 347     Fields:    Translation:HumansAnimalsCells
    82. The tiny conductor: immune regulation via commensal organisms. . 2008 Jun 12; 3(6):340-1. Cassel SL, Sutterwala FS, Flavell RA. PMID: 18541208.
      View in: PubMed   Mentions:
    83. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008 Jun 19; 453(7198):1122-6. Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. PMID: 18496530.
      View in: PubMed   Mentions: 536     Fields:    Translation:AnimalsCells
    84. Immunology: cascade into clarity. Nature. 2008 Jan 17; 451(7176):254-5. Sutterwala FS, Flavell RA. PMID: 18202632.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    85. Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin. Cell Microbiol. 2008 May; 10(5):1190-207. Reig N, Jiang A, Couture R, Sutterwala FS, Ogura Y, Flavell RA, Mellman I, van der Goot FG. PMID: 18194483.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    86. Autoinflammatory syndromes and infections: pathogenetic and clinical implications. Clin Exp Rheumatol. 2008 Jan-Feb; 26(1 Suppl 48):S53-61. Efthimiou P, Flavell RA, Furlan A, Gasbarrini G, Gava A, Koné-Paut I, Manna R, Punzi L, Sutterwala FS, Touitou I, Doria A. PMID: 18570755.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    87. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med. 2007 Dec 24; 204(13):3235-45. Sutterwala FS, Mijares LA, Li L, Ogura Y, Kazmierczak BI, Flavell RA. PMID: 18070936.
      View in: PubMed   Mentions: 244     Fields:    Translation:AnimalsCells
    88. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. J Immunol. 2007 Oct 01; 179(7):4783-91. Pedra JH, Sutterwala FS, Sukumaran B, Ogura Y, Qian F, Montgomery RR, Flavell RA, Fikrig E. PMID: 17878377.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    89. IL-12/23p40-dependent clearance of Anaplasma phagocytophilum in the murine model of human anaplasmosis. FEMS Immunol Med Microbiol. 2007 Aug; 50(3):401-10. Pedra JH, Tao J, Sutterwala FS, Sukumaran B, Berliner N, Bockenstedt LK, Flavell RA, Yin Z, Fikrig E. PMID: 17521390.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    90. The inflammasome in pathogen recognition and inflammation. J Leukoc Biol. 2007 Aug; 82(2):259-64. Sutterwala FS, Ogura Y, Flavell RA. PMID: 17470531.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    91. MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol. 2007 Jul; 82(1):177-83. Pan Q, Mathison J, Fearns C, Kravchenko VV, Da Silva Correia J, Hoffman HM, Kobayashi KS, Bertin J, Grant EP, Coyle AJ, Sutterwala FS, Ogura Y, Flavell RA, Ulevitch RJ. PMID: 17403772.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    92. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity. 2006 Dec; 25(6):941-52. Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA. PMID: 17137799.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    93. The inflammasome: first line of the immune response to cell stress. Cell. 2006 Aug 25; 126(4):659-62. Ogura Y, Sutterwala FS, Flavell RA. PMID: 16923387.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    94. Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med. 2006 Jun 12; 203(6):1407-12. Lara-Tejero M, Sutterwala FS, Ogura Y, Grant EP, Bertin J, Coyle AJ, Flavell RA, Galán JE. PMID: 16717117.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
    95. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity. 2006 Mar; 24(3):317-27. Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase PW, Flavell RA. PMID: 16546100.
      View in: PubMed   Mentions: 402     Fields:    Translation:AnimalsCells
    96. NALP3: a key player in caspase-1 activation. J Endotoxin Res. 2006; 12(4):251-6. Sutterwala FS, Ogura Y, Zamboni DS, Roy CR, Flavell RA. PMID: 16953978.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    97. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science. 2005 Jun 10; 308(5728):1626-9. Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. PMID: 15860593.
      View in: PubMed   Mentions: 337     Fields:    Translation:AnimalsCells
    98. Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol. 2005 Jun; 6(6):600-7. Laouar Y, Sutterwala FS, Gorelik L, Flavell RA. PMID: 15852008.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    99. Suppression of Il-12 transcription in macrophages following Fc gamma receptor ligation. J Immunol. 2001 Apr 01; 166(7):4498-506. Grazia Cappiello M, Sutterwala FS, Trinchieri G, Mosser DM, Ma X. PMID: 11254706.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    100. The taming of IL-12: suppressing the production of proinflammatory cytokines. J Leukoc Biol. 1999 May; 65(5):543-51. Sutterwala FS, Mosser DM. PMID: 10331481.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    101. Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med. 1998 Jul 06; 188(1):217-22. Sutterwala FS, Noel GJ, Salgame P, Mosser DM. PMID: 9653099.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    102. Structural model of cytochrome b559 in photosystem II based on a mutant with genetically fused subunits. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):14173-8. McNamara VP, Sutterwala FS, Pakrasi HB, Whitmarsh J. PMID: 9391172.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    103. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J Exp Med. 1997 Jun 02; 185(11):1977-85. Sutterwala FS, Noel GJ, Clynes R, Mosser DM. PMID: 9166427.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    104. Leishmania major-human macrophage interactions: cooperation between Mac-1 (CD11b/CD18) and complement receptor type 1 (CD35) in promastigote adhesion. Infect Immun. 1996 Jun; 64(6):2206-15. Rosenthal LA, Sutterwala FS, Kehrli ME, Mosser DM. PMID: 8675328.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    105. Cooperation between CR1 (CD35) and CR3 (CD 11b/CD18) in the binding of complement-opsonized particles. J Leukoc Biol. 1996 Jun; 59(6):883-90. Sutterwala FS, Rosenthal LA, Mosser DM. PMID: 8691074.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
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