Timothy Robert Crother

Title(s)Adjunct Professor, Pediatrics
SchoolMedicine
Emailtimothy.crother@cshs.org
ORCID ORCID Icon0000-0001-9042-2909 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, Irvine, IrvineB.Sc.06/1991Biology
    Indiana University, BloomingtonPh.D.03/1999Molecular, Cellular, and Developmental Biology
    University of California, Los Angeles, Los Angeles07/2006Lyme Disease

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    Collapse Overview
    As a researcher, one of my key interests has centered on host-pathogen interactions. This has led me to investigate how Borrelia burgdorferi, the causative agent of Lyme Disease, remakes itself when it infects a mammalian host, and how Chlamydia pneumoniae infections can drive asthmatic responses, and also exacerbate atherosclerotic plaque development. More recently, I have become interested in the possibility that infectious agents may play a role in the development and progression of Alzheimer’s Disease. While there is evidence that infections may play a role in AD, few direct studies have been attempted, highlighting the need for new investigations.
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    Chlamydia pneumoniae infection accelerated Alzheimer’s Disease.
    Alzheimer's Association AARG-NTF-21-84658Oct 1, 2021 - Sep 30, 2024
    Role: Principal Investigators
    Description: Using mouse models we will investigate the relationship between Chlamydia pneumoniae infection and Alzheimer's
    The role of Chlamydia pneumoniae infection in Alzheimer's Disease
    NIH R01AG075998Sep 30, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Role of Rip2 in the Generation of Pathogenic Th17/Th1 T-cells and Ileitis
    NIH R21AI156311Dec 7, 2020 - Nov 30, 2022
    Role: Principal Investigator
    The role of the inflammasome in plasmacytoid dendritic cells during bacterial infection
    NIH R21AI112826Jun 15, 2015 - May 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18). Marek-Iannucci S, Ozdemir AB, Moreira D, Gomez AC, Lane M, Porritt RA, Lee Y, Shimada K, Abe M, Stotland A, Zemmour D, Parker S, Sanchez-Lopez E, Van Eyk J, Gottlieb RA, Fishbein MC, Karin M, Crother TR, Rivas MN, Arditi M. PMID: 34403365; PMCID: PMC8492304.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    2. NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis. Circ Res. 2021 10 15; 129(9):e183-e200. Porritt RA, Zemmour D, Abe M, Lee Y, Narayanan M, Carvalho TT, Gomez AC, Martinon D, Santiskulvong C, Fishbein MC, Chen S, Crother TR, Shimada K, Arditi M, Noval Rivas M. PMID: 34517723; PMCID: PMC8555446.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    3. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021 07 13; 54(7):1463-1477.e11. Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E. PMID: 34115964; PMCID: PMC8189765.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    4. Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M. PMID: 33361152; PMCID: PMC7817159.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model. Front Immunol. 2020; 11:554725. Tumurkhuu G, Chen S, Montano EN, Ercan Laguna D, De Los Santos G, Yu JM, Lane M, Yamashita M, Markman JL, Blanco LP, Kaplan MJ, Shimada K, Crother TR, Ishimori M, Wallace DJ, Jefferies CA, Arditi M. PMID: 33072095; PMCID: PMC7541920.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    6. Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice. JACC Basic Transl Sci. 2020 Jun; 5(6):582-598. Chen S, Markman JL, Shimada K, Crother TR, Lane M, Abolhesn A, Shah PK, Arditi M. PMID: 32613145; PMCID: PMC7315187.
      View in: PubMed   Mentions: 13  
    7. MD-2 as a possible therapeutic target for atherosclerosis. EBioMedicine. 2020 05; 55:102760. Chen S, Crother TR. PMID: 32388463; PMCID: PMC7217989.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Loss of testosterone impairs anti-tumor neutrophil function. Nat Commun. 2020 03 31; 11(1):1613. Markman JL, Porritt RA, Wakita D, Lane ME, Martinon D, Noval Rivas M, Luu M, Posadas EM, Crother TR, Arditi M. PMID: 32235862; PMCID: PMC7109066.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Autophagy Protects Against Developing Increased Lung Permeability and Hypoxemia by Down Regulating Inflammasome Activity and IL-1β in LPS Plus Mechanical Ventilation-Induced Acute Lung Injury. Front Immunol. 2020; 11:207. Nosaka N, Martinon D, Moreira D, Crother TR, Arditi M, Shimada K. PMID: 32117318; PMCID: PMC7033480.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    10. IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis. Clin Exp Immunol. 2020 03; 199(3):303-313. Abe M, Rastelli DD, Gomez AC, Cingolani E, Lee Y, Soni PR, Fishbein MC, Lehman TJA, Shimada K, Crother TR, Chen S, Noval Rivas M, Arditi M. PMID: 31758701; PMCID: PMC7008220.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation. Immunity. 2019 09 17; 51(3):508-521.e6. Noval Rivas M, Wakita D, Franklin MK, Carvalho TT, Abolhesn A, Gomez AC, Fishbein MC, Chen S, Lehman TJ, Sato K, Shibuya A, Fasano A, Kiyono H, Abe M, Tatsumoto N, Yamashita M, Crother TR, Shimada K, Arditi M. PMID: 31471109; PMCID: PMC6751009.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    12. IL-1 receptor antagonist, anakinra, prevents myocardial dysfunction in a mouse model of Kawasaki disease vasculitis and myocarditis. Clin Exp Immunol. 2019 10; 198(1):101-110. Gorelik M, Lee Y, Abe M, Andrews T, Davis L, Patterson J, Chen S, Crother TR, Aune GJ, Noval Rivas M, Arditi M. PMID: 31099056; PMCID: PMC6718290.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    13. Autophagy Limits Inflammasome During Chlamydia pneumoniae Infection. Front Immunol. 2019; 10:754. Crother TR, Porritt RA, Dagvadorj J, Tumurkhuu G, Slepenkin AV, Peterson EM, Chen S, Shimada K, Arditi M. PMID: 31031755; PMCID: PMC6473188.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis. JCI Insight. 2019 Feb 07; 4(3). Matundan HH, Sin J, Rivas MN, Fishbein MC, Lehman TJ, Chen S, Gottlieb RA, Crother TR, Abe M, Arditi M. PMID: 30728329; PMCID: PMC6413776.
      View in: PubMed   Mentions: 9     Fields:    
    15. T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation. Immunity. 2018 11 20; 49(5):873-885.e7. Shimada K, Porritt RA, Markman JL, O'Rourke JG, Wakita D, Noval Rivas M, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M. PMID: 30366765; PMCID: PMC6260980.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice. PLoS Pathog. 2018 09; 14(9):e1007260. Skalski JH, Limon JJ, Sharma P, Gargus MD, Nguyen C, Tang J, Coelho AL, Hogaboam CM, Crother TR, Underhill DM. PMID: 30235351; PMCID: PMC6147580.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsPHPublic Health
    17. Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells. Cancer Med. 2018 09; 7(9):4639-4649. Cavassani KA, Meza RJ, Habiel DM, Chen JF, Montes A, Tripathi M, Martins GA, Crother TR, You S, Hogaboam CM, Bhowmick N, Posadas EM. PMID: 30094958; PMCID: PMC6143932.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    18. Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018 09 04; 28(3):432-448.e4. Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S. PMID: 29937375; PMCID: PMC6125162.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Optimal tube length of orotracheal intubation for mice. Lab Anim. 2019 Feb; 53(1):79-83. Nosaka N, Crother TR, Chen S, Arditi M, Shimada K. PMID: 29649932; PMCID: PMC6203655.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis. J Am Coll Cardiol. 2018 04 10; 71(14):1553-1570. Chen S, Shimada K, Crother TR, Erbay E, Shah PK, Arditi M. PMID: 29622163; PMCID: PMC6042865.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis. Sci Rep. 2017 02 02; 7:41539. Domiciano TP, Wakita D, Jones HD, Crother TR, Verri WA, Arditi M, Shimada K. PMID: 28148962; PMCID: PMC5288648.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    22. CD8+ T Cells Contribute to the Development of Coronary Arteritis in the Lactobacillus casei Cell Wall Extract-Induced Murine Model of Kawasaki Disease. Arthritis Rheumatol. 2017 Feb; 69(2):410-421. Noval Rivas M, Lee Y, Wakita D, Chiba N, Dagvadorj J, Shimada K, Chen S, Fishbein MC, Lehman TJ, Crother TR, Arditi M. PMID: 27696768; PMCID: PMC5274597.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    23. The microbiome in asthma. Curr Opin Pediatr. 2016 12; 28(6):764-771. Noval Rivas M, Crother TR, Arditi M. PMID: 27606957; PMCID: PMC5241015.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    24. Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res. 2016 Sep 02; 119(6):e76-90. Tumurkhuu G, Shimada K, Dagvadorj J, Crother TR, Zhang W, Luthringer D, Gottlieb RA, Chen S, Arditi M. PMID: 27384322; PMCID: PMC5010464.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    25. Immunological Consequences of Intestinal Fungal Dysbiosis. Cell Host Microbe. 2016 Jun 08; 19(6):865-73. Wheeler ML, Limon JJ, Bar AS, Leal CA, Gargus M, Tang J, Brown J, Funari VA, Wang HL, Crother TR, Arditi M, Underhill DM, Iliev ID. PMID: 27237365; PMCID: PMC4900921.
      View in: PubMed   Mentions: 170     Fields:    Translation:AnimalsCells
    26. Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2016 05; 36(5):886-97. Wakita D, Kurashima Y, Crother TR, Noval Rivas M, Lee Y, Chen S, Fury W, Bai Y, Wagner S, Li D, Lehman T, Fishbein MC, Hoffman HM, Shah PK, Shimada K, Arditi M. PMID: 26941015; PMCID: PMC4850105.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    27. Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016; 7(3-4):237-254. Porritt RA, Crother TR. PMID: 30687565; PMCID: PMC6345537.
      View in: PubMed   Mentions: 16  
    28. IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β. Arterioscler Thromb Vasc Biol. 2015 Dec; 35(12):2605-16. Lee Y, Wakita D, Dagvadorj J, Shimada K, Chen S, Huang G, Lehman TJ, Fishbein MC, Hoffman HM, Crother TR, Arditi M. PMID: 26515418; PMCID: PMC4662607.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    29. POPsicle for Fever! Cooling Down the Inflammasome. Immunity. 2015 Aug 18; 43(2):213-5. Shimada K, Crother TR, Arditi M. PMID: 26287676.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    30. Correction: Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One. 2015; 10(5):e0128735. Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K. PMID: 25996479; PMCID: PMC4440726.
      View in: PubMed   Mentions: 3     Fields:    
    31. Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration. PLoS One. 2015; 10(4):e0123460. Jones HD, Yoo J, Crother TR, Kyme P, Ben-Shlomo A, Khalafi R, Tseng CW, Parks WC, Arditi M, Liu GY, Shimada K. PMID: 25875775; PMCID: PMC4395431.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    32. Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release. Immunity. 2015 Apr 21; 42(4):640-53. Dagvadorj J, Shimada K, Chen S, Jones HD, Tumurkhuu G, Zhang W, Wawrowsky KA, Crother TR, Arditi M. PMID: 25862090; PMCID: PMC4423803.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    33. Mast cells play an important role in chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway. J Immunol. 2015 Apr 15; 194(8):3840-51. Chiba N, Shimada K, Chen S, Jones HD, Alsabeh R, Slepenkin AV, Peterson E, Crother TR, Arditi M. PMID: 25754739; PMCID: PMC4390505.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice. Cell Immunol. 2015 Mar; 294(1):25-32. Sorrentino R, Yilmaz A, Schubert K, Crother TR, Pinto A, Shimada K, Arditi M, Chen S. PMID: 25666507; PMCID: PMC4391498.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    35. Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation. J Immunol. 2015 Feb 15; 194(4):1686-94. Tumurkhuu G, Dagvadorj J, Jones HD, Chen S, Shimada K, Crother TR, Arditi M. PMID: 25576596; PMCID: PMC4323992.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    36. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):270-80. Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, Arditi M, Shimada K. PMID: 24007300; PMCID: PMC3930947.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    37. Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis. PLoS One. 2013; 8(10):e77447. Jupelli M, Shimada K, Chiba N, Slepenkin A, Alsabeh R, Jones HD, Peterson E, Chen S, Arditi M, Crother TR. PMID: 24204830; PMCID: PMC3808399.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    38. Plasmacytoid dendritic cells play a key role in tumor progression in lipopolysaccharide-stimulated lung tumor-bearing mice. J Immunol. 2013 Mar 01; 190(5):2391-402. Rega A, Terlizzi M, Luciano A, Forte G, Crother TR, Arra C, Arditi M, Pinto A, Sorrentino R. PMID: 23355734.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Plasmacytoid dendritic cells play a role for effective innate immune responses during Chlamydia pneumoniae infection in mice. PLoS One. 2012; 7(10):e48655. Crother TR, Ma J, Jupelli M, Chiba N, Chen S, Slepenkin A, Alsabeh R, Peterson E, Shimada K, Arditi M. PMID: 23119083; PMCID: PMC3485374.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    40. Innate immune responses to Chlamydia pneumoniae infection: role of TLRs, NLRs, and the inflammasome. Microbes Infect. 2012 Nov; 14(14):1301-7. Shimada K, Crother TR, Arditi M. PMID: 22985781; PMCID: PMC3511600.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    41. Plasmacytoid dendritic cells and their therapeutic activity in cancer. Oncoimmunology. 2012 Aug 01; 1(5):726-734. Pinto A, Rega A, Crother TR, Sorrentino R. PMID: 22934264; PMCID: PMC3429576.
      View in: PubMed   Mentions: 18     Fields:    
    42. Marked acceleration of atherosclerosis after Lactobacillus casei-induced coronary arteritis in a mouse model of Kawasaki disease. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):e60-71. Chen S, Lee Y, Crother TR, Fishbein M, Zhang W, Yilmaz A, Shimada K, Schulte DJ, Lehman TJ, Shah PK, Arditi M. PMID: 22628430; PMCID: PMC3480341.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    43. Interleukin-1� is crucial for the induction of coronary artery inflammation in a mouse model of Kawasaki disease. Circulation. 2012 Mar 27; 125(12):1542-50. Lee Y, Schulte DJ, Shimada K, Chen S, Crother TR, Chiba N, Fishbein MC, Lehman TJ, Arditi M. PMID: 22361326; PMCID: PMC3337219.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    44. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012 Mar 23; 36(3):401-14. Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, Ramanujan VK, Wolf AJ, Vergnes L, Ojcius DM, Rentsendorj A, Vargas M, Guerrero C, Wang Y, Fitzgerald KA, Underhill DM, Town T, Arditi M. PMID: 22342844; PMCID: PMC3312986.
      View in: PubMed   Mentions: 836     Fields:    Translation:AnimalsCells
    45. Myeloid differentiation factor-2 interacts with Lyn kinase and is tyrosine phosphorylated following lipopolysaccharide-induced activation of the TLR4 signaling pathway. J Immunol. 2011 Oct 15; 187(8):4331-7. Gray P, Dagvadorj J, Michelsen KS, Brikos C, Rentsendorj A, Town T, Crother TR, Arditi M. PMID: 21918188; PMCID: PMC3186846.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    46. Caspase-1 dependent IL-1� secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. PLoS One. 2011; 6(6):e21477. Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M. PMID: 21731762; PMCID: PMC3121765.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    47. Chlamydia pneumoniae infection induced allergic airway sensitization is controlled by regulatory T-cells and plasmacytoid dendritic cells. PLoS One. 2011; 6(6):e20784. Crother TR, Schr?der NW, Karlin J, Chen S, Shimada K, Slepenkin A, Alsabeh R, Peterson E, Arditi M. PMID: 21695198; PMCID: PMC3112152.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    48. Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. PLoS One. 2010 Oct 15; 5(10):e15044. Soliman A, Michelsen KS, Karahashi H, Lu J, Meng FJ, Qu X, Crother TR, Rabizadeh S, Chen S, Caplan MS, Arditi M, Jilling T. PMID: 20976181; PMCID: PMC2955554.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    49. IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-accelerated atherosclerosis in mice. J Immunol. 2010 Nov 01; 185(9):5619-27. Chen S, Shimada K, Zhang W, Huang G, Crother TR, Arditi M. PMID: 20935201; PMCID: PMC3046880.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    50. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One. 2010 Sep 27; 5(9):e13027. Lowe EL, Crother TR, Rabizadeh S, Hu B, Wang H, Chen S, Shimada K, Wong MH, Michelsen KS, Arditi M. PMID: 20885960; PMCID: PMC2946405.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    51. Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma. J Immunol. 2010 Oct 15; 185(8):4641-50. Sorrentino R, Morello S, Luciano A, Crother TR, Maiolino P, Bonavita E, Arra C, Adcock IM, Arditi M, Pinto A. PMID: 20855872.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    52. Emerging role of IL-17 in atherosclerosis. J Innate Immun. 2010; 2(4):325-33. Chen S, Crother TR, Arditi M. PMID: 20505315; PMCID: PMC2895754.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    53. Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling. J Immunol. 2010 Jun 01; 184(11):6359-66. Gray P, Michelsen KS, Sirois CM, Lowe E, Shimada K, Crother TR, Chen S, Brikos C, Bulut Y, Latz E, Underhill D, Arditi M. PMID: 20435923; PMCID: PMC3057206.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    54. Plasmacytoid dendritic cells prevent cigarette smoke and Chlamydophila pneumoniae-induced Th2 inflammatory responses. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):422-31. Sorrentino R, Gray P, Chen S, Shimada K, Crother TR, Arditi M. PMID: 19901344; PMCID: PMC2951872.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    55. Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease. J Immunol. 2009 Oct 15; 183(8):5311-8. Schulte DJ, Yilmaz A, Shimada K, Fishbein MC, Lowe EL, Chen S, Wong M, Doherty TM, Lehman T, Crother TR, Sorrentino R, Arditi M. PMID: 19786535; PMCID: PMC3031986.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    56. Chlamydial heat shock protein 60 induces acute pulmonary inflammation in mice via the Toll-like receptor 4- and MyD88-dependent pathway. Infect Immun. 2009 Jul; 77(7):2683-90. Bulut Y, Shimada K, Wong MH, Chen S, Gray P, Alsabeh R, Doherty TM, Crother TR, Arditi M. PMID: 19398543; PMCID: PMC2708574.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    57. The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog. 2009 Apr; 5(4):e1000379. Shimada K, Chen S, Dempsey PW, Sorrentino R, Alsabeh R, Slepenkin AV, Peterson E, Doherty TM, Underhill D, Crother TR, Arditi M. PMID: 19360122; PMCID: PMC2660273.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    58. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol. 2008 Nov 15; 181(10):7176-85. Naiki Y, Sorrentino R, Wong MH, Michelsen KS, Shimada K, Chen S, Yilmaz A, Slepenkin A, Schröder NW, Crother TR, Bulut Y, Doherty TM, Bradley M, Shaposhnik Z, Peterson EM, Tontonoz P, Shah PK, Arditi M. PMID: 18981139; PMCID: PMC2683843.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    59. Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation. J Immunol. 2008 Nov 15; 181(10):7186-93. Chen S, Sorrentino R, Shimada K, Bulut Y, Doherty TM, Crother TR, Arditi M. PMID: 18981140; PMCID: PMC2662697.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    60. Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization. J Allergy Clin Immunol. 2008 Sep; 122(3):595-602.e5. Schröder NW, Crother TR, Naiki Y, Chen S, Wong MH, Yilmaz A, Slepenkin A, Schulte D, Alsabeh R, Doherty TM, Peterson E, Nel AE, Arditi M. PMID: 18774395; PMCID: PMC3052793.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    61. Analysis of bacterial membrane proteins produced during mammalian infection using hydrophobic antigen tissue triton extraction (HATTREX). Curr Protoc Microbiol. 2008 May; Chapter 12:Unit 12.1. Crother TR, Nally JE. PMID: 18770532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    62. Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin. Infect Immun. 2004 Sep; 72(9):5063-72. Crother TR, Champion CI, Whitelegge JP, Aguilera R, Wu XY, Blanco DR, Miller JN, Lovett MA. PMID: 15321999; PMCID: PMC517453.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    63. Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation. J Proteome Res. 2004 May-Jun; 3(3):445-54. Tu X, Huang A, Bae D, Slaughter N, Whitelegge J, Crother T, Bickel PE, Nel A. PMID: 15253425.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    64. Antigenic composition of Borrelia burgdorferi during infection of SCID mice. Infect Immun. 2003 Jun; 71(6):3419-28. Crother TR, Champion CI, Wu XY, Blanco DR, Miller JN, Lovett MA. PMID: 12761126; PMCID: PMC155750.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    65. Structural analysis of adenine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry. 2001 Sep 11; 40(36):10800-9. Shi W, Tanaka KS, Crother TR, Taylor MW, Almo SC, Schramm VL. PMID: 11535055.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    66. Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase. J Bacteriol. 1999 May; 181(9):2984-6. Guetsova ML, Crother TR, Taylor MW, Daignan-Fornier B. PMID: 10217799; PMCID: PMC93750.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    67. APT1, but not APT2, codes for a functional adenine phosphoribosyltransferase in Saccharomyces cerevisiae. J Bacteriol. 1999 Jan; 181(1):347-52. Alfonzo JD, Crother TR, Guetsova ML, Daignan-Fornier B, Taylor MW. PMID: 9864350; PMCID: PMC103569.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    68. Site directed mutagenesis of the Saccharomyces cerevisiae APT1 gene. A functional and enzymatic analysis. Adv Exp Med Biol. 1998; 431:299-303. Crother TR, Taylor MW. PMID: 9598079.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    69. Relationship of the two APRT gene products from Saccharomyces cerevisiae. Adv Exp Med Biol. 1998; 431:309-14. Crother TR, Taylor MW. PMID: 9598081.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
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