Elizabeth Joanna Aguiar Vallim
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| Title(s) | Associate Professor-in-Residence, Medicine |
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| School | Medicine |
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| vCard | Download vCard |
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Biography
| UCLA | 2011 | | George J. Popjàk Award for Outstanding Contributions in the field of Atherosclerosis Research |
| Kern Lipid Conference | 2017 | | David L. Williams Lectureship & Award for Outstanding Research in the field of Lipids & Lipoproteins |
| ATVB Council of the American Heart Association | 2018 | | Irvine H. Page Young Investigator Research Award |
| UCLA MBIDP | 2022 | | MBIDP First-Year Curriculum Instructor Award |
Overview
Lipids (particularly cholesterol and phospholipids) are essential components of cell membranes and are precursors to many signaling molecules, including steroid hormones, bile acids, second messengers, and oxysterols. As such, lipid synthesis pathways are among the most intensely regulated processes in biology. We are interested in understanding molecular mechanisms that control cellular, tissue and whole-body lipid homeostasis in healthy and disease states.
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Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Methionine supplementation: potential for improving alveolar macrophage function through reverse cholesterol transport? Eur Respir J. 2022 05; 59(5).
O'Callaghan M, Helly F, Tarling E, Keane MP, McCarthy C. PMID: 34857611.
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HumansCells
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Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol Med. 2022 04 07; 14(4):e15344.
Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR, Walter P, Erbay E. PMID: 35191199; PMCID: PMC8988208.
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1 Fields:
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AnimalsCells
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The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review. Front Immunol. 2021; 12:752856.
Ataya A, Knight V, Carey BC, Lee E, Tarling EJ, Wang T. PMID: 34880857; PMCID: PMC8647160.
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PubMed Mentions:
8 Fields:
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HumansAnimals
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FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab. 2021 08 03; 33(8):1671-1684.e4.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. . PMID: 34270928; PMCID: PMC8353952.
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PubMed Mentions:
37 Fields:
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HumansAnimals
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mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis. Circ Res. 2021 05 28; 128(11):1660-1662.
de Aguiar Vallim TQ, Tarling EJ. PMID: 34043422; PMCID: PMC8171811.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience. 2021 Jun 25; 24(6):102537.
Zhuang A, Calkin AC, Lau S, Kiriazis H, Donner DG, Liu Y, Bond ST, Moody SC, Gould EAM, Colgan TD, Carmona SR, Inouye M, de Aguiar Vallim TQ, Tarling EJ, Quaife-Ryan GA, Hudson JE, Porrello ER, Gregorevic P, Gao XM, Du XJ, McMullen JR, Drew BG. PMID: 34142046; PMCID: PMC8184514.
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6
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Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance. Nat Commun. 2021 01 04; 12(1):74.
Bond ST, King EJ, Henstridge DC, Tran A, Moody SC, Yang C, Liu Y, Mellett NA, Nath AP, Inouye M, Tarling EJ, de Aguiar Vallim TQ, Meikle PJ, Calkin AC, Drew BG. PMID: 33397965; PMCID: PMC7782476.
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PubMed Mentions:
2 Fields:
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AnimalsCells
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Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 07; 21(7):746-755.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064; PMCID: PMC7778040.
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PubMed Mentions:
30 Fields:
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HumansAnimalsCells
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MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice. Arterioscler Thromb Vasc Biol. 2020 02; 40(2):412-425.
Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ. . PMID: 31852219; PMCID: PMC7018399.
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PubMed Mentions:
13 Fields:
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Animals
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An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 03; 567(7747):187-193.
Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. PMID: 30814737; PMCID: PMC6656374.
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36 Fields:
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HumansAnimalsCells
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Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun. 2018 08 07; 9(1):3127.
McCarthy C, Lee E, Bridges JP, Sallese A, Suzuki T, Woods JC, Bartholmai BJ, Wang T, Chalk C, Carey BC, Arumugam P, Shima K, Tarling EJ, Trapnell BC. PMID: 30087322; PMCID: PMC6081448.
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PubMed Mentions:
23 Fields:
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HumansAnimalsCells
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Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018 09 04; 28(3):432-448.e4.
Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S. PMID: 29937375; PMCID: PMC6125162.
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PubMed Mentions:
25 Fields:
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AnimalsCells
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NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 11 20; 8(1):1620.
Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. PMID: 29158473; PMCID: PMC5696341.
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PubMed Mentions:
102 Fields:
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HumansAnimalsCells
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RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. J Clin Invest. 2017 Oct 02; 127(10):3741-3754.
Tarling EJ, Clifford BL, Cheng J, Morand P, Cheng A, Lester E, Sallam T, Turner M, de Aguiar Vallim TQ. . PMID: 28891815; PMCID: PMC5617661.
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PubMed Mentions:
30 Fields:
Translation:
Animals
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ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017 05; 58(5):941-954.
de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á, Tarling EJ. PMID: 28264879; PMCID: PMC5408613.
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16 Fields:
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HumansAnimalsCells
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Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report. Arterioscler Thromb Vasc Biol. 2016 07; 36(7):1323-7.
Tarling EJ, Edwards PA. PMID: 27230131; PMCID: PMC4919203.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Maternal high-fat feeding in pregnancy programs atherosclerotic lesion size in the ApoE*3 Leiden mouse. J Dev Orig Health Dis. 2016 Jun; 7(3):290-297.
Tarling EJ, Ryan KJP, Austin R, Kugler SJ, Salter AM, Langley-Evans SC. PMID: 26829884.
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2 Fields:
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Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17; 163(7):1716-29.
York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. PMID: 26686653; PMCID: PMC4783382.
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PubMed Mentions:
182 Fields:
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HumansAnimalsCells
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ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction. J Lipid Res. 2015 Dec; 56(12):2337-47.
Wei H, Tarling EJ, McMillen TS, Tang C, LeBoeuf RC. PMID: 26489644; PMCID: PMC4655989.
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PubMed Mentions:
11 Fields:
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AnimalsCells
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LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015 Jul 14; 4:e08009.
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. PMID: 26173179; PMCID: PMC4517437.
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PubMed Mentions:
127 Fields:
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AnimalsCells
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MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 03; 21(2):298-311.
de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. PMID: 25651182; PMCID: PMC4317590.
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40 Fields:
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HumansAnimalsCells
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The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):787-95.
Tarling EJ, Ahn H, de Aguiar Vallim TQ. . PMID: 25593129; PMCID: PMC4376635.
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PubMed Mentions:
15 Fields:
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HumansAnimalsCells
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ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 01; 193(11):5637-48.
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. PMID: 25339664; PMCID: PMC4239162.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 05; 18(5):685-97.
Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. PMID: 24206663; PMCID: PMC3889491.
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142 Fields:
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HumansAnimalsCells
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Response to Pomozi et al's research commentary. Circ Res. 2013 May 24; 112(11):e152-3.
Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 23625949; PMCID: PMC3999040.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Pleiotropic roles of bile acids in metabolism. Cell Metab. 2013 May 07; 17(5):657-69.
de Aguiar Vallim TQ, Tarling EJ, Edwards PA. PMID: 23602448; PMCID: PMC3654004.
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PubMed Mentions:
385 Fields:
Translation:
Humans
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Expanding roles of ABCG1 and sterol transport. Curr Opin Lipidol. 2013 Apr; 24(2):138-46.
Tarling EJ. PMID: 23340182.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res. 2013 Jun 07; 112(12):1602-12.
de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. PMID: 23519696; PMCID: PMC3995747.
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PubMed Mentions:
81 Fields:
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HumansAnimalsCells
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Role of ABC transporters in lipid transport and human disease. Trends Endocrinol Metab. 2013 Jul; 24(7):342-50.
Tarling EJ, de Aguiar Vallim TQ, Edwards PA. PMID: 23415156; PMCID: PMC3659191.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimals
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ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17; 111(5):516-20.
Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 22811557; PMCID: PMC3540978.
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PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19719-24.
Tarling EJ, Edwards PA. PMID: 22095132; PMCID: PMC3241749.
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PubMed Mentions:
101 Fields:
Translation:
HumansAnimalsCells
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Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. Biochim Biophys Acta. 2012 Mar; 1821(3):386-95.
Tarling EJ, Edwards PA. PMID: 21824529.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res. 2010 Nov; 51(11):3185-95.
Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR. PMID: 20675829; PMCID: PMC2952559.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol. 2010 Jun; 30(6):1174-80.
Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, Bjorkhem I, Edwards PA. PMID: 20299684; PMCID: PMC2881948.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Emerging new paradigms for ABCG transporters. Biochim Biophys Acta. 2009 Jul; 1791(7):584-93.
Tarr PT, Tarling EJ, Bojanic DD, Edwards PA, Baldán A. PMID: 19416657; PMCID: PMC2698934.
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PubMed Mentions:
59 Fields:
Translation:
Animals
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Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets. Br J Nutr. 2009 Jun; 101(11):1630-8.
Tarling EJ, Ryan KJ, Bennett AJ, Salter AM. PMID: 18983716; PMCID: PMC2695940.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Maternal undernutrition programmes atherosclerosis in the ApoE*3-Leiden mouse. Br J Nutr. 2009 Apr; 101(8):1185-94.
Yates Z, Tarling EJ, Langley-Evans SC, Salter AM. PMID: 18782462; PMCID: PMC2670275.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Regulation of gene transcription by fatty acids. Animal. 2007 Oct; 1(9):1314-20.
Salter AM, Tarling EJ. PMID: 22444886.
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PubMed Mentions:
6 Fields:
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Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma. Biochem Biophys Res Commun. 2005 Nov 25; 337(3):824-31.
O'Sullivan SE, Tarling EJ, Bennett AJ, Kendall DA, Randall MD. PMID: 16213464.
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PubMed Mentions:
58 Fields:
Translation:
Animals
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
|---|
| 2005 | 1 |
| 2007 | 1 |
| 2008 | 2 |
| 2009 | 1 |
| 2010 | 2 |
| 2011 | 2 |
| 2012 | 1 |
| 2013 | 6 |
| 2014 | 1 |
| 2015 | 5 |
| 2016 | 2 |
| 2017 | 3 |
| 2018 | 2 |
| 2019 | 2 |
| 2020 | 1 |
| 2021 | 5 |
| 2022 | 2 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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