Elizabeth Joanna Tarling

Title(s)Professor-in-residence, Medicine
SchoolMedicine
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    Collapse Biography 
    Collapse Awards and Honors
    UCLA2011George J. Popjàk Award for Outstanding Contributions in the field of Atherosclerosis Research
    Kern Lipid Conference2017David L. Williams Lectureship & Award for Outstanding Research in the field of Lipids & Lipoproteins
    ATVB Council of the American Heart Association2018Irvine H. Page Young Investigator Research Award
    UCLA MBIDP2022MBIDP First-Year Curriculum Instructor Award

    Collapse Overview 
    Collapse Overview
    Lipids (particularly cholesterol and phospholipids) are essential components of cell membranes and are precursors to many signaling molecules, including steroid hormones, bile acids, second messengers, and oxysterols. As such, lipid synthesis pathways are among the most intensely regulated processes in biology. We are interested in understanding molecular mechanisms that control cellular, tissue and whole-body lipid homeostasis in healthy and disease states.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Re-Examining the Role of Pulmonary Lipids in the Pathogenesis of Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2024 May 31. O'Callaghan M, Tarling EJ, Bridges JP, Redente EF, Byrne AJ, Keane MP, McCarthy C. PMID: 38820234.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation. J Clin Invest. 2024 May 21; 134(13). Hong SG, Ashby JW, Kennelly JP, Wu M, Steel M, Chattopadhyay E, Foreman R, Tontonoz P, Tarling EJ, Turowski P, Gallagher-Jones M, Mack JJ. PMID: 38771648; PMCID: PMC11213468.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Alveolar macrophage lipid burden correlates with clinical improvement in patients with pulmonary alveolar proteinosis. J Lipid Res. 2024 02; 65(2):100496. Lee E, Williams KJ, McCarthy C, Bridges JP, Redente EF, de Aguiar Vallim TQ, Barrington RA, Wang T, Tarling EJ. PMID: 38185217; PMCID: PMC10844116.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume (CTPFAV ) in idiopathic pulmonary fibrosis. Respirology. 2023 11; 28(11):1043-1052. O'Callaghan M, Duignan J, Tarling EJ, Waters DK, McStay M, O'Carroll O, Bridges JP, Redente EF, Franciosi AN, McGrath EE, Butler MW, Dodd JD, Fabre A, Murphy DJ, Keane MP, McCarthy C. PMID: 37642207.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Circ Res. 2023 03 31; 132(7):849-863. Clifford BL, Jarrett KE, Cheng J, Cheng A, Seldin M, Morand P, Lee R, Chen M, Baldan A, de Aguiar Vallim TQ, Tarling EJ. PMID: 36876496; PMCID: PMC10065965.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. Methionine supplementation: potential for improving alveolar macrophage function through reverse cholesterol transport? Eur Respir J. 2022 05; 59(5). O'Callaghan M, Helly F, Tarling E, Keane MP, McCarthy C. PMID: 34857611.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol Med. 2022 04 07; 14(4):e15344. Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR, Walter P, Erbay E. PMID: 35191199; PMCID: PMC8988208.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    8. The Role of GM-CSF Autoantibodies in Infection and Autoimmune Pulmonary Alveolar Proteinosis: A Concise Review. Front Immunol. 2021; 12:752856. Ataya A, Knight V, Carey BC, Lee E, Tarling EJ, Wang T. PMID: 34880857; PMCID: PMC8647160.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    9. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab. 2021 08 03; 33(8):1671-1684.e4. Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. PMID: 34270928; PMCID: PMC8353952.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    10. mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis. Circ Res. 2021 05 28; 128(11):1660-1662. de Aguiar Vallim TQ, Tarling EJ. PMID: 34043422; PMCID: PMC8171811.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience. 2021 Jun 25; 24(6):102537. Zhuang A, Calkin AC, Lau S, Kiriazis H, Donner DG, Liu Y, Bond ST, Moody SC, Gould EAM, Colgan TD, Carmona SR, Inouye M, de Aguiar Vallim TQ, Tarling EJ, Quaife-Ryan GA, Hudson JE, Porrello ER, Gregorevic P, Gao XM, Du XJ, McMullen JR, Drew BG. PMID: 34142046; PMCID: PMC8184514.
      View in: PubMed   Mentions: 11  
    12. Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance. Nat Commun. 2021 01 04; 12(1):74. Bond ST, King EJ, Henstridge DC, Tran A, Moody SC, Yang C, Liu Y, Mellett NA, Nath AP, Inouye M, Tarling EJ, de Aguiar Vallim TQ, Meikle PJ, Calkin AC, Drew BG. PMID: 33397965; PMCID: PMC7782476.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 07; 21(7):746-755. Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. PMID: 32514064; PMCID: PMC7778040.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    14. MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice. Arterioscler Thromb Vasc Biol. 2020 02; 40(2):412-425. Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ. PMID: 31852219; PMCID: PMC7018399.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    15. An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 03; 567(7747):187-193. Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. PMID: 30814737; PMCID: PMC6656374.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    16. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun. 2018 08 07; 9(1):3127. McCarthy C, Lee E, Bridges JP, Sallese A, Suzuki T, Woods JC, Bartholmai BJ, Wang T, Chalk C, Carey BC, Arumugam P, Shima K, Tarling EJ, Trapnell BC. PMID: 30087322; PMCID: PMC6081448.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    17. Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018 09 04; 28(3):432-448.e4. Tumurkhuu G, Dagvadorj J, Porritt RA, Crother TR, Shimada K, Tarling EJ, Erbay E, Arditi M, Chen S. PMID: 29937375; PMCID: PMC6125162.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    18. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 11 20; 8(1):1620. Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. PMID: 29158473; PMCID: PMC5696341.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimalsCells
    19. RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. J Clin Invest. 2017 Oct 02; 127(10):3741-3754. Tarling EJ, Clifford BL, Cheng J, Morand P, Cheng A, Lester E, Sallam T, Turner M, de Aguiar Vallim TQ. PMID: 28891815; PMCID: PMC5617661.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    20. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017 05; 58(5):941-954. de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á, Tarling EJ. PMID: 28264879; PMCID: PMC5408613.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report. Arterioscler Thromb Vasc Biol. 2016 07; 36(7):1323-7. Tarling EJ, Edwards PA. PMID: 27230131; PMCID: PMC4919203.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Maternal high-fat feeding in pregnancy programs atherosclerotic lesion size in the ApoE*3 Leiden mouse. J Dev Orig Health Dis. 2016 Jun; 7(3):290-297. Tarling EJ, Ryan KJP, Austin R, Kugler SJ, Salter AM, Langley-Evans SC. PMID: 26829884.
      View in: PubMed   Mentions: 2     Fields:    
    23. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17; 163(7):1716-29. York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. PMID: 26686653; PMCID: PMC4783382.
      View in: PubMed   Mentions: 232     Fields:    Translation:HumansAnimalsCells
    24. ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction. J Lipid Res. 2015 Dec; 56(12):2337-47. Wei H, Tarling EJ, McMillen TS, Tang C, LeBoeuf RC. PMID: 26489644; PMCID: PMC4655989.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015 Jul 14; 4:e08009. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. PMID: 26173179; PMCID: PMC4517437.
      View in: PubMed   Mentions: 145     Fields:    Translation:AnimalsCells
    26. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 03; 21(2):298-311. de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. PMID: 25651182; PMCID: PMC4317590.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    27. The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):787-95. Tarling EJ, Ahn H, de Aguiar Vallim TQ. PMID: 25593129; PMCID: PMC4376635.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    28. ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 01; 193(11):5637-48. Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. PMID: 25339664; PMCID: PMC4239162.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    29. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab. 2013 Nov 05; 18(5):685-97. Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. PMID: 24206663; PMCID: PMC3889491.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    30. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24; 112(11):e152-3. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 23625949; PMCID: PMC3999040.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    31. Pleiotropic roles of bile acids in metabolism. Cell Metab. 2013 May 07; 17(5):657-69. de Aguiar Vallim TQ, Tarling EJ, Edwards PA. PMID: 23602448; PMCID: PMC3654004.
      View in: PubMed   Mentions: 498     Fields:    Translation:Humans
    32. Expanding roles of ABCG1 and sterol transport. Curr Opin Lipidol. 2013 Apr; 24(2):138-46. Tarling EJ. PMID: 23340182.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    33. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res. 2013 Jun 07; 112(12):1602-12. de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. PMID: 23519696; PMCID: PMC3995747.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    34. Role of ABC transporters in lipid transport and human disease. Trends Endocrinol Metab. 2013 Jul; 24(7):342-50. Tarling EJ, de Aguiar Vallim TQ, Edwards PA. PMID: 23415156; PMCID: PMC3659191.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimals
    35. ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17; 111(5):516-20. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 22811557; PMCID: PMC3540978.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    36. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19719-24. Tarling EJ, Edwards PA. PMID: 22095132; PMCID: PMC3241749.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    37. Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. Biochim Biophys Acta. 2012 Mar; 1821(3):386-95. Tarling EJ, Edwards PA. PMID: 21824529.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    38. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res. 2010 Nov; 51(11):3185-95. Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR. PMID: 20675829; PMCID: PMC2952559.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    39. Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol. 2010 Jun; 30(6):1174-80. Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, Bjorkhem I, Edwards PA. PMID: 20299684; PMCID: PMC2881948.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    40. Emerging new paradigms for ABCG transporters. Biochim Biophys Acta. 2009 Jul; 1791(7):584-93. Tarr PT, Tarling EJ, Bojanic DD, Edwards PA, Baldán A. PMID: 19416657; PMCID: PMC2698934.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    41. Effect of dietary conjugated linoleic acid isomers on lipid metabolism in hamsters fed high-carbohydrate and high-fat diets. Br J Nutr. 2009 Jun; 101(11):1630-8. Tarling EJ, Ryan KJ, Bennett AJ, Salter AM. PMID: 18983716; PMCID: PMC2695940.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    42. Maternal undernutrition programmes atherosclerosis in the ApoE*3-Leiden mouse. Br J Nutr. 2009 Apr; 101(8):1185-94. Yates Z, Tarling EJ, Langley-Evans SC, Salter AM. PMID: 18782462; PMCID: PMC2670275.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    43. Regulation of gene transcription by fatty acids. Animal. 2007 Oct; 1(9):1314-20. Salter AM, Tarling EJ. PMID: 22444886.
      View in: PubMed   Mentions: 6     Fields:    
    44. Novel time-dependent vascular actions of Delta9-tetrahydrocannabinol mediated by peroxisome proliferator-activated receptor gamma. Biochem Biophys Res Commun. 2005 Nov 25; 337(3):824-31. O'Sullivan SE, Tarling EJ, Bennett AJ, Kendall DA, Randall MD. PMID: 16213464.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    45. Transcriptional regulation of human SREBP-1c (sterol-regulatory-element-binding protein-1c): a key regulator of lipogenesis. Biochem Soc Trans. 2004 Feb; 32(Pt 1):107-9. Tarling E, Salter A, Bennett A. PMID: 14748724.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
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