Louis-Serge Bouchard

Title(s)Associate Professor, Chemistry and Biochemistry
SchoolCollege of Letters and Science
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    1. BayesAge 2.0: a maximum likelihood algorithm to predict transcriptomic age. Geroscience. 2025 Jan 03. Mboning L, Costa EK, Chen J, Bouchard LS, Pellegrini M. PMID: 39751713.
      View in: PubMed   Mentions:    Fields:    
    2. BayesAge 2.0: A Maximum Likelihood Algorithm to Predict Transcriptomic Age. bioRxiv. 2024 Sep 19. Mboning L, Costa EK, Chen J, Bouchard LS, Pellegrini M. PMID: 39345375; PMCID: PMC11429879.
      View in: PubMed   Mentions:
    3. BayesAge: A maximum likelihood algorithm to predict epigenetic age. Front Bioinform. 2024; 4:1329144. Mboning L, Rubbi L, Thompson M, Bouchard LS, Pellegrini M. PMID: 38638123; PMCID: PMC11024280.
      View in: PubMed   Mentions: 2  
    4. Harnessing Biomaterials to Amplify Immunity in Aged Mice through T Memory Stem Cells. ACS Nano. 2024 Mar 05; 18(9):6908-6926. Hasani-Sadrabadi MM, Majedi FS, Zarubova J, Thauland TJ, Arumugaswami V, Hsiai TK, Bouchard LS, Butte MJ, Li S. PMID: 38381620.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Nuclear induction line shape: Non-Markovian diffusion with boundaries. J Chem Phys. 2024 Jan 14; 160(2). Niknam M, Bouchard LS. PMID: 38193557.
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    6. Dual-Signal Chemical Exchange Saturation Transfer (Dusi-CEST): An Efficient Strategy for Visualizing Drug Delivery Monitoring in Living Cells. Anal Chem. 2024 01 30; 96(4):1436-1443. Yuan C, Guo Q, Zeng Q, Yuan Y, Jiang W, Yang Y, Bouchard LS, Ye C, Zhou X. PMID: 38173081.
      View in: PubMed   Mentions:    Fields:    
    7. Nuclear induction lineshape modeling via hybrid SDE and MD approach. J Chem Phys. 2023 Sep 28; 159(12). Niknam M, Bouchard LS. PMID: 38127390.
      View in: PubMed   Mentions:    Fields:    
    8. Systemic enhancement of antitumour immunity by peritumourally implanted immunomodulatory macroporous scaffolds. Nat Biomed Eng. 2023 Jan; 7(1):56-71. Majedi FS, Hasani-Sadrabadi MM, Thauland TJ, Keswani SG, Li S, Bouchard LS, Butte MJ. PMID: 36550304; PMCID: PMC9940651.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium. Nat Commun. 2022 10 27; 13(1):6394. Cokic I, Chan SF, Guan X, Nair AR, Yang HJ, Liu T, Chen Y, Hernando D, Sykes J, Tang R, Butler J, Dohnalkova A, Kovarik L, Finney R, Kali A, Sharif B, Bouchard LS, Gupta R, Krishnam MS, Vora K, Tamarappoo B, Howarth AG, Kumar A, Francis J, Reeder SB, Wood JC, Prato FS, Dharmakumar R. PMID: 36302906; PMCID: PMC9613644.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    10. Mapping Cell Viability Quantitatively and Independently From Cell Density in 3D Gels Noninvasively. IEEE Trans Biomed Eng. 2021 10; 68(10):2940-2947. Archer BJ, Mack JJ, Acosta S, Nakasone R, Dahoud F, Youssef K, Goldstein A, Goldsman A, Held MC, Wiese M, Blumich B, Wessling M, Emondts M, Klankermayer J, Iruela-Arispe ML, Bouchard LS. PMID: 33531296; PMCID: PMC8326301.
      View in: PubMed   Mentions:    Fields:    
    11. Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI. Sci Adv. 2021 01; 7(1). Li H, Zhao X, Wang Y, Lou X, Chen S, Deng H, Shi L, Xie J, Tang D, Zhao J, Bouchard LS, Xia L, Zhou X. PMID: 33219111; PMCID: PMC7775756.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    12. Augmenting T-cell responses to tumors by in situ nanomanufacturing. Mater Horiz. 2020 Nov 01; 7(11):3028-3033. Hasani-Sadrabadi MM, Majedi FS, Miller ML, Thauland TJ, Bouchard LS, Li S, Butte MJ. PMID: 33343906; PMCID: PMC7748250.
      View in: PubMed   Mentions: 2     Fields:    
    13. T-cell activation is modulated by the 3D mechanical microenvironment. Biomaterials. 2020 09; 252:120058. Majedi FS, Hasani-Sadrabadi MM, Thauland TJ, Li S, Bouchard LS, Butte MJ. PMID: 32413594; PMCID: PMC7307918.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    14. Augmentation of T-Cell Activation by Oscillatory Forces and Engineered Antigen-Presenting Cells. Nano Lett. 2019 10 09; 19(10):6945-6954. Majedi FS, Hasani-Sadrabadi MM, Thauland TJ, Li S, Bouchard LS, Butte MJ. PMID: 31478664; PMCID: PMC6786928.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst. Chemistry. 2019 Aug 22; 25(47):11031-11035. Kaltschnee L, Jagtap AP, McCormick J, Wagner S, Bouchard LS, Utz M, Griesinger C, Glöggler S. PMID: 31347750.
      View in: PubMed   Mentions: 15     Fields:    
    16. Nuclear Spin Singlet States in Photoactive Molecules: From Fluorescence/NMR Bimodality to a Bimolecular Switch for Spin Singlet States. Angew Chem Int Ed Engl. 2019 02 25; 58(9):2879-2883. Yang S, McCormick J, Mamone S, Bouchard LS, Glöggler S. PMID: 30629796.
      View in: PubMed   Mentions: 3     Fields:    
    17. Breakdown of Carr-Purcell Meiboom-Gill spin echoes in inhomogeneous fields. J Chem Phys. 2018 Aug 28; 149(8):084304. Jarenwattananon NN, Bouchard LS. PMID: 30193488.
      View in: PubMed   Mentions: 2     Fields:    
    18. Noninvasive Quantification of Cell Density in Three-Dimensional Gels by MRI. IEEE Trans Biomed Eng. 2019 03; 66(3):821-830. Archer BJ, Uberruck T, Mack JJ, Youssef K, Jarenwattananon NN, Rall D, Wypysek D, Wiese M, Blumich B, Wessling M, Iruela-Arispe ML, Bouchard LS. PMID: 30028689; PMCID: PMC7811270.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. More Than 12 % Polarization and 20 Minute Lifetime of 15 N in a Choline Derivative Utilizing Parahydrogen and a Rhodium Nanocatalyst in Water. Angew Chem Int Ed Engl. 2018 08 13; 57(33):10692-10696. McCormick J, Korchak S, Mamone S, Ertas YN, Liu Z, Verlinsky L, Wagner S, Glöggler S, Bouchard LS. PMID: 29923285.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    20. Mechanobiological Mimicry of Helper T Lymphocytes to Evaluate Cell-Biomaterials Crosstalk. Adv Mater. 2018 Jun; 30(23):e1706780. Hasani-Sadrabadi MM, Majedi FS, Bensinger SJ, Wu BM, Bouchard LS, Weiss PS, Moshaverinia A. PMID: 29682803.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    21. Cytokine Secreting Microparticles Engineer the Fate and the Effector Functions of T-Cells. Adv Mater. 2018 Feb; 30(7). Majedi FS, Hasani-Sadrabadi MM, Kidani Y, Thauland TJ, Moshaverinia A, Butte MJ, Bensinger SJ, Bouchard LS. PMID: 29315824; PMCID: PMC5854475.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    22. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 11 20; 8(1):1620. Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. PMID: 29158473; PMCID: PMC5696341.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    23. Effects of Cd vacancies and unconventional spin dynamics in the Dirac semimetal Cd3As2. J Chem Phys. 2017 Aug 28; 147(8):084706. Koumoulis D, Taylor RE, McCormick J, Ertas YN, Pan L, Che X, Wang KL, Bouchard LS. PMID: 28863530.
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    24. Targeted nanodiamonds for identification of subcellular protein assemblies in mammalian cells. PLoS One. 2017; 12(6):e0179295. Lake MP, Bouchard LS. PMID: 28636640; PMCID: PMC5479563.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Aqueous Ligand-Stabilized Palladium Nanoparticle Catalysts for Parahydrogen-Induced 13C Hyperpolarization. Anal Chem. 2017 07 05; 89(13):7190-7194. McCormick J, Grunfeld AM, Ertas YN, Biswas AN, Marsh KL, Wagner S, Glöggler S, Bouchard LS. PMID: 28590115.
      View in: PubMed   Mentions: 7     Fields:    
    26. Mitochondria Targeted and Intracellular Biothiol Triggered Hyperpolarized 129Xe Magnetofluorescent Biosensor. Anal Chem. 2017 02 21; 89(4):2288-2295. Zeng Q, Guo Q, Yuan Y, Yang Y, Zhang B, Ren L, Zhang X, Luo Q, Liu M, Bouchard LS, Zhou X. PMID: 28192930.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    27. Jarenwattananon and Bouchard Reply. Phys Rev Lett. 2016 12 09; 117(24):249702. Jarenwattananon NN, Bouchard L. PMID: 28009200.
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    28. Direct Chemical Fine-Tuning of Electronic Properties in Sc2 Ir6-x Pdx B. Chemphyschem. 2016 Oct 05; 17(19):2972-2976. Koumoulis D, Scheifers JP, St Touzani R, Fokwa BP, Bouchard LS. PMID: 27415033.
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    29. Erratum: Motional Averaging of Nuclear Resonance in a Field Gradient [Phys. Rev. Lett. 114, 197601 (2015)]. Phys Rev Lett. 2016 May 27; 116(21):219903. Jarenwattananon NN, Bouchard LS. PMID: 27284678.
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    30. Biothiol Xenon MRI Sensor Based on Thiol-Addition Reaction. Anal Chem. 2016 06 07; 88(11):5835-40. Yang S, Jiang W, Ren L, Yuan Y, Zhang B, Luo Q, Guo Q, Bouchard LS, Liu M, Zhou X. PMID: 27128102.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    31. 4-D Flow Control in Porous Scaffolds: Toward a Next Generation of Bioreactors. IEEE Trans Biomed Eng. 2017 01; 64(1):61-69. Youssef K, Jarenwattananon NN, Archer BJ, Mack J, Iruela-Arispe ML, Bouchard LS. PMID: 26955013; PMCID: PMC8006392.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    32. Surface ligand-directed pair-wise hydrogenation for heterogeneous phase hyperpolarization. Chem Commun (Camb). 2016 Jan 11; 52(3):605-8. Glöggler S, Grunfeld AM, Ertas YN, McCormick J, Wagner S, Bouchard LS. PMID: 26553609.
      View in: PubMed   Mentions: 4     Fields:    
    33. Nanoscale β-nuclear magnetic resonance depth imaging of topological insulators. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):E3645-50. Koumoulis D, Morris GD, He L, Kou X, King D, Wang D, Hossain MD, Wang KL, Fiete GA, Kanatzidis MG, Bouchard LS. PMID: 26124141; PMCID: PMC4507211.
      View in: PubMed   Mentions: 3     Fields:    
    34. Hyperpolarization of amino acid derivatives in water for biological applications. Chem Sci. 2015 Jul 01; 6(7):4261-4266. Glöggler S, Wagner S, Bouchard LS. PMID: 29218193; PMCID: PMC5707458.
      View in: PubMed   Mentions: 9  
    35. Motional averaging of nuclear resonance in a field gradient. Phys Rev Lett. 2015 May 15; 114(19):197601. Jarenwattananon NN, Bouchard LS. PMID: 26024197.
      View in: PubMed   Mentions:    Fields:    
    36. Feature-Preserving Noise Removal. IEEE Trans Med Imaging. 2015 Sep; 34(9):1822-9. Youssef K, Jarenwattananon NN, Bouchard LS. PMID: 25769149.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    37. A nanoparticle catalyst for heterogeneous phase para-hydrogen-induced polarization in water. Angew Chem Int Ed Engl. 2015 Feb 16; 54(8):2452-6. Glöggler S, Grunfeld AM, Ertas YN, McCormick J, Wagner S, Schleker PP, Bouchard LS. PMID: 25565403.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    38. Thermal maps of gases in heterogeneous reactions. Nature. 2013 Oct 24; 502(7472):537-40. Jarenwattananon NN, Glöggler S, Otto T, Melkonian A, Morris W, Burt SR, Yaghi OM, Bouchard LS. PMID: 24153305.
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    39. NMR probe of metallic states in nanoscale topological insulators. Phys Rev Lett. 2013 Jan 11; 110(2):026602. Koumoulis D, Chasapis TC, Taylor RE, Lake MP, King D, Jarenwattananon NN, Fiete GA, Kanatzidis MG, Bouchard LS. PMID: 23383927.
      View in: PubMed   Mentions: 5     Fields:    
    40. Nanodiamond landmarks for subcellular multimodal optical and electron imaging. Sci Rep. 2013; 3:2668. Zurbuchen MA, Lake MP, Kohan SA, Leung B, Bouchard LS. PMID: 24036840; PMCID: PMC3773618.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    41. Real-time maps of fluid flow fields in porous biomaterials. Biomaterials. 2013 Mar; 34(8):1980-6. Mack JJ, Youssef K, Noel OD, Lake MP, Wu A, Iruela-Arispe ML, Bouchard LS. PMID: 23245922; PMCID: PMC3714210.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    42. Strongly hyperpolarized gas from parahydrogen by rational design of ligand-capped nanoparticles. Sci Rep. 2012; 2:277. Sharma R, Bouchard LS. PMID: 22355789; PMCID: PMC3282305.
      View in: PubMed   Mentions: 6     Fields:    
    43. Relaxivity of gadolinium complexes detected by atomic magnetometry. Magn Reson Med. 2011 Aug; 66(2):605-8. Michalak DJ, Xu S, Lowery TJ, Crawford CW, Ledbetter M, Bouchard LS, Wemmer DE, Budker D, Pines A. PMID: 21433067.
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    44. Universality of cluster dynamics. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Dec; 82(6 Pt 1):061125. McFadden C, Bouchard LS. PMID: 21230662.
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    45. A heteronuclear zero quantum coherence Nz-exchange experiment that resolves resonance overlap and its application to measure the rates of heme binding to the IsdC protein. J Am Chem Soc. 2010 Jul 21; 132(28):9522-3. Robson SA, Peterson R, Bouchard LS, Villareal VA, Clubb RT. PMID: 20578738; PMCID: PMC2912433.
      View in: PubMed   Mentions: 5     Fields:    
    46. Shimmed matching pulses: simultaneous control of rf and static gradients for inhomogeneity correction. J Chem Phys. 2009 Dec 21; 131(23):234506. Franck JM, Demas V, Martin RW, Bouchard LS, Pines A. PMID: 20025334.
      View in: PubMed   Mentions:    Fields:    
    47. Distortion-free magnetic resonance imaging in the zero-field limit. J Magn Reson. 2009 Oct; 200(2):285-90. Kelso N, Lee SK, Bouchard LS, Demas V, Mück M, Pines A, Clarke J. PMID: 19664947.
      View in: PubMed   Mentions: 1     Fields:    
    48. Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4085-9. Bouchard LS, Anwar MS, Liu GL, Hann B, Xie ZH, Gray JW, Wang X, Pines A, Chen FF. PMID: 19251659; PMCID: PMC2657430.
      View in: PubMed   Mentions: 48     Fields:    
    49. Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20601-4. Paulsen JL, Bouchard LS, Graziani D, Blümich B, Pines A. PMID: 19091950; PMCID: PMC2634945.
      View in: PubMed   Mentions: 3     Fields:    
    50. NMR imaging of catalytic hydrogenation in microreactors with the use of para-hydrogen. Science. 2008 Jan 25; 319(5862):442-5. Bouchard LS, Burt SR, Anwar MS, Kovtunov KV, Koptyug IV, Pines A. PMID: 18218891.
      View in: PubMed   Mentions: 35     Fields:    
    51. Spin coherence transfer in chemical transformations monitored by remote detection NMR. Anal Chem. 2007 Apr 01; 79(7):2806-11. Anwar MS, Hilty C, Chu C, Bouchard LS, Pierce KL, Pines A. PMID: 17335181.
      View in: PubMed   Mentions: 1     Fields:    
    52. Para-hydrogen-enhanced hyperpolarized gas-phase magnetic resonance imaging. Angew Chem Int Ed Engl. 2007; 46(22):4064-8. Bouchard LS, Kovtunov KV, Burt SR, Anwar MS, Koptyug IV, Sagdeev RZ, Pines A. PMID: 17455180.
      View in: PubMed   Mentions: 17     Fields:    
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