Thomas Aguiar Vallim

Title(s)Associate Professor, Medicine
SchoolMedicine
ORCID ORCID Icon0000-0001-7642-5046 Additional info
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    Other Positions
    Title(s)Associate Professor, Biological Chemistry


    Collapse Biography 
    Collapse education and training
    University of Nottingham, EnglandMSci07/2002Biochemistry and Biological Chemistry
    University of Nottingham, EnglandPhD03/2008Nutritional Biochemistry
    University of California Los Angeles, USAPost-doc01/2013Lipid Metabolism
    Collapse awards and honors
    UCLA2013George Popják Scholar Award for Outstanding Contribution to the Field of Atherosclerosis
    ATVB Council of the AHA2015Irvine H. Page Young Investigator Research Award Winner
    Kern Lipid Conference 2016David L. Williams Award Winner
    American Heart Association 2017Paul Dudley White International Scholar
    ATVB Council of the AHA2017Outstanding Research Award

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    Bile acid-mediated control of lipid absorption and fatty liver disease
    NIH 1R01DK138340-01Dec 15, 2023 - Nov 30, 2027
    Role: Principal Investigator
    Targeting the gut-liver axis in cardiovascular disease
    NIH R01HL163908Dec 15, 2022 - Nov 30, 2026
    Role: Co-Principal Investigator
    ATP Binding Cassette Transporters in Health and Disease
    NIH R01DK128952Apr 9, 2021 - Jan 31, 2025
    Role: Co-Principal Investigator
    Novel FXR-dependent Molecular Mechanisms in the Regulation of Liver Metabolism
    NIH R01DK118064Mar 15, 2019 - Dec 31, 2022
    Role: Co-Principal Investigator
    Novel Post-Transcriptional Regulators of Lipid Metabolism
    NIH R01DK112119Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Transcriptional control of microRNAs in lipid metabolism and atherosclerosis
    NIH R01HL122677May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones. Cell Metab. 2025 Jan 07; 37(1):255-273.e6. Rauckhorst AJ, Sheldon RD, Pape DJ, Ahmed A, Falls-Hubert KC, Merrill RA, Brown RF, Deshmukh K, Vallim TA, Deja S, Burgess SC, Taylor EB. PMID: 39471817; PMCID: PMC11856365.
      View in: PubMed   Mentions:    Fields:    
    2. Alveolar macrophage lipid burden correlates with clinical improvement in patients with pulmonary alveolar proteinosis. J Lipid Res. 2024 02; 65(2):100496. Lee E, Williams KJ, McCarthy C, Bridges JP, Redente EF, de Aguiar Vallim TQ, Barrington RA, Wang T, Tarling EJ. PMID: 38185217; PMCID: PMC10844116.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins. Cell Rep. 2024 01 23; 43(1):113627. Sunshine HL, Cicchetto AC, Kaczor-Urbanowicz KE, Ma F, Pi D, Symons C, Turner M, Shukla V, Christofk HR, Vallim TA, Iruela-Arispe ML. PMID: 38157296; PMCID: PMC10884959.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module. J Hepatol. 2024 Mar; 80(3):467-481. Bendixen SM, Jakobsgaard PR, Hansen D, Hejn KH, Terkelsen MK, Bjerre FA, Thulesen AP, Eriksen NG, Hallenborg P, Geng Y, Dam TV, Larsen FT, Wernberg CW, Vijayathurai J, Scott EAH, Marcher AB, Detlefsen S, Grøntved L, Dimke H, Berdeaux R, de Aguiar Vallim TQ, Olinga P, Lauridsen MM, Krag A, Blagoev B, Ravnskjaer K. PMID: 37972658.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res. 2024 02; 65(2):100434. Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ. PMID: 37640283; PMCID: PMC10839691.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. ZFP36-mediated mRNA decay regulates metabolism. Cell Rep. 2023 05 30; 42(5):112411. Cicchetto AC, Jacobson EC, Sunshine H, Wilde BR, Krall AS, Jarrett KE, Sedgeman L, Turner M, Plath K, Iruela-Arispe ML, de Aguiar Vallim TQ, Christofk HR. PMID: 37086408; PMCID: PMC10332406.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    7. RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Circ Res. 2023 03 31; 132(7):849-863. Clifford BL, Jarrett KE, Cheng J, Cheng A, Seldin M, Morand P, Lee R, Chen M, Baldan A, de Aguiar Vallim TQ, Tarling EJ. PMID: 36876496; PMCID: PMC10065965.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    8. Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Nat Metab. 2023 01; 5(1):165-181. Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. PMID: 36646756; PMCID: PMC9995220.
      View in: PubMed   Mentions: 8     Fields:    
    9. Expression of Synj2bp in mouse liver regulates the extent of wrappER-mitochondria contact to maintain hepatic lipid homeostasis. Biol Direct. 2022 12 01; 17(1):37. Ilacqua N, Anastasia I, Aloshyn D, Ghandehari-Alavijeh R, Peluso EA, Brearley-Sholto MC, Pellegrini LV, Raimondi A, de Aguiar Vallim TQ, Pellegrini L. PMID: 36457006; PMCID: PMC9717519.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. 2022 04; 42(4):381-394. Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR. PMID: 35172604; PMCID: PMC8957608.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. In Vivo Gene Editing in Lipid and Atherosclerosis Research. Methods Mol Biol. 2022; 2419:673-713. De Giorgi M, Jarrett KE, de Aguiar Vallim TQ, Lagor WR. PMID: 35237996.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation. J Lipid Res. 2022 Jan; 63(1):100153. Mukherjee P, Chattopadhyay A, Grijalva V, Dorreh N, Lagishetty V, Jacobs JP, Clifford BL, Vallim T, Mack JJ, Navab M, Reddy ST, Fogelman AM. PMID: 34808192; PMCID: PMC8953663.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. A three-organelle complex made by wrappER contacts with peroxisomes and mitochondria responds to liver lipid flux changes. J Cell Sci. 2022 03 01; 135(5). Ilacqua N, Anastasia I, Raimondi A, Lemieux P, de Aguiar Vallim TQ, Toth K, Koonin EV, Pellegrini L. PMID: 34672330; PMCID: PMC8627550.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    14. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab. 2021 08 03; 33(8):1671-1684.e4. Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. . PMID: 34270928; PMCID: PMC8353952.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimals
    15. mInd the gAP: Intestinal Alkaline Phosphatase Puts the Breaks on Atherosclerosis. Circ Res. 2021 05 28; 128(11):1660-1662. de Aguiar Vallim TQ, Tarling EJ. PMID: 34043422; PMCID: PMC8171811.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience. 2021 Jun 25; 24(6):102537. Zhuang A, Calkin AC, Lau S, Kiriazis H, Donner DG, Liu Y, Bond ST, Moody SC, Gould EAM, Colgan TD, Carmona SR, Inouye M, de Aguiar Vallim TQ, Tarling EJ, Quaife-Ryan GA, Hudson JE, Porrello ER, Gregorevic P, Gao XM, Du XJ, McMullen JR, Drew BG. PMID: 34142046; PMCID: PMC8184514.
      View in: PubMed   Mentions: 11  
    17. Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis. Cell Rep. 2021 03 16; 34(11):108873. Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G, Mekhedov SL, Williams KJ, Caicci F, Valle G, Giacomello M, Quiroga AD, Lehner R, Miksis MJ, Toth K, de Aguiar Vallim TQ, Koonin EV, Scorrano L, Pellegrini L. PMID: 33730569.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    18. Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. 2021 05 04; 143(18):1809-1823. von Scheidt M, Zhao Y, de Aguiar Vallim TQ, Che N, Wierer M, Seldin MM, Franzén O, Kurt Z, Pang S, Bongiovanni D, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic JC, Mann M, Björkegren JLM, Lusis AJ, Yang X, Schunkert H. PMID: 33626882; PMCID: PMC8124091.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    19. Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance. Nat Commun. 2021 01 04; 12(1):74. Bond ST, King EJ, Henstridge DC, Tran A, Moody SC, Yang C, Liu Y, Mellett NA, Nath AP, Inouye M, Tarling EJ, de Aguiar Vallim TQ, Meikle PJ, Calkin AC, Drew BG. PMID: 33397965; PMCID: PMC7782476.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    20. MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice. Arterioscler Thromb Vasc Biol. 2020 02; 40(2):412-425. Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ. . PMID: 31852219; PMCID: PMC7018399.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    21. An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 03; 567(7747):187-193. Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. PMID: 30814737; PMCID: PMC6656374.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    22. Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018 09 20; 175(1):117-132.e21. Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. PMID: 30197082; PMCID: PMC6151140.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    23. Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants. J Lipid Res. 2018 03; 59(3):429-438. Lee JM, Ong JR, Vergnes L, de Aguiar Vallim TQ, Nolan J, Cantor RM, Walters JRF, Reue K. PMID: 29295820; PMCID: PMC5832924.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    24. NOTCH1 is a mechanosensor in adult arteries. Nat Commun. 2017 11 20; 8(1):1620. Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML. PMID: 29158473; PMCID: PMC5696341.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    25. Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 2017 10 25; 6. Zhang L, Rajbhandari P, Priest C, Sandhu J, Wu X, Temel R, Castrillo A, de Aguiar Vallim TQ, Sallam T, Tontonoz P. PMID: 29068315; PMCID: PMC5656429.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    26. RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. J Clin Invest. 2017 Oct 02; 127(10):3741-3754. Tarling EJ, Clifford BL, Cheng J, Morand P, Cheng A, Lester E, Sallam T, Turner M, de Aguiar Vallim TQ. . PMID: 28891815; PMCID: PMC5617661.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    27. ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017 Oct 02; 127(10):3640-3651. Rong X, Wang B, Palladino EN, de Aguiar Vallim TQ, Ford DA, Tontonoz P. PMID: 28846071; PMCID: PMC5617651.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    28. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017 05; 58(5):941-954. de Aguiar Vallim TQ, Lee E, Merriott DJ, Goulbourne CN, Cheng J, Cheng A, Gonen A, Allen RM, Palladino END, Ford DA, Wang T, Baldán Á, Tarling EJ. PMID: 28264879; PMCID: PMC5408613.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Translational and Therapeutic Approaches to the Understanding and Treatment of Dyslipidemia. Arterioscler Thromb Vasc Biol. 2016 07; 36(7):e56-61. Zhang H, de Aguiar Vallim TQ, Martel C, Early Career Committee. PMID: 27335468; PMCID: PMC4920133.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 06; 57(6):925-42. Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. PMID: 27099397; PMCID: PMC4878195.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    31. Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628; PMCID: PMC4934679.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansAnimalsCells
    32. miRNAs and High-Density Lipoprotein metabolism. Biochim Biophys Acta. 2016 12; 1861(12 Pt B):2053-2061. Baldán Á, de Aguiar Vallim TQ. . PMID: 26869447; PMCID: PMC4980286.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    33. SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res. 2016 Mar; 57(3):410-21. Vergnes L, Chin RG, de Aguiar Vallim T, Fong LG, Osborne TF, Young SG, Reue K. PMID: 26685326; PMCID: PMC4766990.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    34. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 03; 21(2):298-311. de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. PMID: 25651182; PMCID: PMC4317590.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    35. The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):787-95. Tarling EJ, Ahn H, de Aguiar Vallim TQ. . PMID: 25593129; PMCID: PMC4376635.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    36. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015 Jan; 56(1):22-37. Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ. PMID: 25378658; PMCID: PMC4274068.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimalsCells
    37. Pleiotropic roles of bile acids in metabolism. Cell Metab. 2013 May 07; 17(5):657-69. de Aguiar Vallim TQ, Tarling EJ, Edwards PA. PMID: 23602448; PMCID: PMC3654004.
      View in: PubMed   Mentions: 509     Fields:    Translation:Humans
    38. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res. 2013 Jun 07; 112(12):1602-12. de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. PMID: 23519696; PMCID: PMC3995747.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    39. Role of ABC transporters in lipid transport and human disease. Trends Endocrinol Metab. 2013 Jul; 24(7):342-50. Tarling EJ, de Aguiar Vallim TQ, Edwards PA. PMID: 23415156; PMCID: PMC3659191.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimals
    40. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 08; 17(1):49-60. Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. PMID: 23312283; PMCID: PMC3771112.
      View in: PubMed   Mentions: 473     Fields:    Translation:HumansAnimalsCells
    41. Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Mol Endocrinol. 2010 Aug; 24(8):1626-36. Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. PMID: 20573685; PMCID: PMC2940469.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
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