Desmond Smith

Title(s)Professor, Molecular and Medical Pharmacology
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    Collapse Research 
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    Genetic pathways for impulsivity and drug reinforcement: DNA and transcriptome variation in mice
    NIH U01DA041602Sep 15, 2017 - May 31, 2022
    Role: Principal Investigator
    A cost-effective platform for high-precision genome analysis of mammalian cells
    NIH R21HG007405May 18, 2015 - Apr 30, 2017
    Role: Principal Investigator
    Deep RNA sequencing and proteomic analysis of a hybrid mouse diversity panel
    NIH R01GM098273Jun 5, 2012 - May 31, 2016
    Role: Principal Investigator
    Transcriptome and proteome mapping of the mouse brain
    NIH R01NS050148Sep 20, 2005 - Aug 31, 2011
    Role: Principal Investigator
    Genome-tagged mice to identify behavior genes
    NIH R01MH071779Jul 1, 2005 - Apr 30, 2010
    Role: Principal Investigator
    Voxelation: a new method for 3D gene expression analysis
    NIH R01DA015802Apr 1, 2002 - Feb 28, 2007
    Role: Principal Investigator
    NIH R21NS039628Sep 1, 2000 - Jun 30, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cost-Effective Mapping of Genetic Interactions in Mammalian Cells. Front Genet. 2021; 12:703738. Khan AH, Smith DJ. PMID: 34434222; PMCID: PMC8381747.
      View in: PubMed   Mentions:
    2. Pooled analysis of radiation hybrids identifies loci for growth and drug action in mammalian cells. Genome Res. 2020 10; 30(10):1458-1467. Khan AH, Lin A, Wang RT, Bloom JS, Lange K, Smith DJ. PMID: 32878976; PMCID: PMC7605260.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes. Elife. 2016 09 13; 5. Hasin-Brumshtein Y, Khan AH, Hormozdiari F, Pan C, Parks BW, Petyuk VA, Piehowski PD, Brümmer A, Pellegrini M, Xiao X, Eskin E, Smith RD, Lusis AJ, Smith DJ. PMID: 27623010; PMCID: PMC5053804.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    4. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 06; 57(6):925-42. Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. PMID: 27099397; PMCID: PMC4878195.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    5. Discovery and characterization of human exonic transcriptional regulatory elements. PLoS One. 2012; 7(9):e46098. Khan AH, Lin A, Smith DJ. PMID: 23029400; PMCID: PMC3454335.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    6. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. PMID: 22892838; PMCID: PMC3586763.
      View in: PubMed   Mentions: 85     Fields:    Translation:Animals
    7. Effects of genome-wide copy number variation on expression in mammalian cells. BMC Genomics. 2011 Nov 16; 12:562. Wang RT, Ahn S, Park CC, Khan AH, Lange K, Smith DJ. PMID: 22085887; PMCID: PMC3287593.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    8. Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet. 2011 Jun; 7(6):e1001393. Ghazalpour A, Bennett B, Petyuk VA, Orozco L, Hagopian R, Mungrue IN, Farber CR, Sinsheimer J, Kang HM, Furlotte N, Park CC, Wen PZ, Brewer H, Weitz K, Camp DG, Pan C, Yordanova R, Neuhaus I, Tilford C, Siemers N, Gargalovic P, Eskin E, Kirchgessner T, Smith DJ, Smith RD, Lusis AJ. PMID: 21695224; PMCID: PMC3111477.
      View in: PubMed   Mentions: 279     Fields:    Translation:AnimalsCells
    9. Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC Syst Biol. 2011 Mar 16; 5:43. Park CC, Gale GD, de Jong S, Ghazalpour A, Bennett BJ, Farber CR, Langfelder P, Lin A, Khan AH, Eskin E, Horvath S, Lusis AJ, Ophoff RA, Smith DJ. PMID: 21410935; PMCID: PMC3070648.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    10. A Poisson model for random multigraphs. Bioinformatics. 2010 Aug 15; 26(16):2004-11. Ranola JM, Ahn S, Sehl M, Smith DJ, Lange K. PMID: 20554690; PMCID: PMC3025746.
      View in: PubMed   Mentions: 5     Fields:    
    11. A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes. Genome Res. 2010 Aug; 20(8):1122-32. Lin A, Wang RT, Ahn S, Park CC, Smith DJ. PMID: 20508145; PMCID: PMC2909575.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    12. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010 Jan; 51(1):169-81. Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lövgren-Sandblom A, Björkhem I, Edwards PA. PMID: 19633360; PMCID: PMC2789777.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    13. Mitochondrial dysfunction in mouse models of Parkinson's disease revealed by transcriptomics and proteomics. J Bioenerg Biomembr. 2009 Dec; 41(6):487-91. Smith DJ. PMID: 19967437; PMCID: PMC2810189.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. Dual spatial maps of transcript and protein abundance in the mouse brain. Expert Rev Proteomics. 2009 Jun; 6(3):243-9. Park CC, Petyuk VA, Qian WJ, Smith RD, Smith DJ. PMID: 19489697; PMCID: PMC2744401.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    15. An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J Bone Miner Res. 2009 Jan; 24(1):105-16. Farber CR, van Nas A, Ghazalpour A, Aten JE, Doss S, Sos B, Schadt EE, Ingram-Drake L, Davis RC, Horvath S, Smith DJ, Drake TA, Lusis AJ. PMID: 18767929; PMCID: PMC2661539.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    16. Screening reveals conserved and nonconserved transcriptional regulatory elements including an E3/E4 allele-dependent APOE coding region enhancer. Genomics. 2008 Nov; 92(5):292-300. Chen HP, Lin A, Bloom JS, Khan AH, Park CC, Smith DJ. PMID: 18718521.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genet. 2008 Aug 08; 4(8):e1000149. Ghazalpour A, Doss S, Kang H, Farber C, Wen PZ, Brozell A, Castellanos R, Eskin E, Smith DJ, Drake TA, Lusis AJ. PMID: 18688273; PMCID: PMC2483929.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    18. Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nat Genet. 2008 Apr; 40(4):421-9. Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ. PMID: 18362883; PMCID: PMC3014048.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    19. Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease. J Proteome Res. 2008 Feb; 7(2):666-77. Chin MH, Qian WJ, Wang H, Petyuk VA, Bloom JS, Sforza DM, Lacan G, Liu D, Khan AH, Cantor RM, Bigelow DJ, Melega WP, Camp DG, Smith RD, Smith DJ. PMID: 18173235; PMCID: PMC3319057.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    20. A genome-scale map of expression for a mouse brain section obtained using voxelation. Physiol Genomics. 2007 Aug 20; 30(3):313-21. Chin MH, Geng AB, Khan AH, Qian WJ, Petyuk VA, Boline J, Levy S, Toga AW, Smith RD, Leahy RM, Smith DJ. PMID: 17504947; PMCID: PMC3299369.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    21. Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors. Neurochem Res. 2007 Feb; 32(2):363-76. Ghiani CA, Beltran-Parrazal L, Sforza DM, Malvar JS, Seksenyan A, Cole R, Smith DJ, Charles A, Ferchmin PA, de Vellis J. PMID: 17191130.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    22. Gene expression is differentially regulated by neurotransmitters in embryonic neuronal cortical culture. J Neurochem. 2006 Apr; 97 Suppl 1:35-43. Ghiani CA, Lelievre V, Beltran-Parrazal L, Sforza DM, Malvar J, Smith DJ, Charles AC, Ferchmin PA, de Vellis J. PMID: 16635248.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics. 2005 Sep; 86(3):259-70. Davis RC, Schadt EE, Smith DJ, Hsieh EW, Cervino AC, van Nas A, Rosales M, Doss S, Meng H, Allayee H, Lusis AJ. PMID: 16039824.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    24. Anatomical methods for voxelation of the mammalian brain. Neurochem Res. 2004 Jun; 29(6):1299-306. Sforza DM, Annese J, Liu D, Levy S, Toga AW, Smith DJ. PMID: 15176486.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    25. Investigation of different transcript quantitation tools for high-throughput mapping of brain gene expression using voxelation. J Mol Histol. 2004 May; 35(4):397-402. Singh RP, Liu D, Chaudhari A, Cherry SR, Leahy RM, Smith DJ. PMID: 15503813.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Mapping behavioral traits by use of genome-tagged mice. Am J Geriatr Psychiatry. 2004 Mar-Apr; 12(2):158-65. Liu D, Singh RP, Khan AH, Lusis AJ, Davis RC, Smith DJ. PMID: 15010345.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    27. Voxelation methods for genome scale imaging of brain gene expression. Methods Enzymol. 2004; 386:314-23. Sforza DM, Smith DJ. PMID: 15120259.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    28. Voxelation and gene expression tomography for the acquisition of 3-D gene expression maps in the brain. Methods. 2003 Dec; 31(4):317-25. Liu D, Smith DJ. PMID: 14597316.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    29. Identifying loci for behavioral traits using genome-tagged mice. J Neurosci Res. 2003 Nov 15; 74(4):562-9. Liu D, Singh RP, Khan AH, Bhavsar K, Lusis AJ, Davis RC, Smith DJ. PMID: 14598300.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    30. Genome scale mapping of brain gene expression. Biol Psychiatry. 2003 Jun 15; 53(12):1069-74. Singh RP, Smith DJ. PMID: 12814858.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    31. High-resolution voxelation mapping of human and rodent brain gene expression. J Neurosci Methods. 2003 May 30; 125(1-2):93-101. Singh RP, Brown VM, Chaudhari A, Khan AH, Ossadtchi A, Sforza DM, Meadors AK, Cherry SR, Leahy RM, Smith DJ. PMID: 12763235.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    32. Neurotrophin-4 is required for tolerance to morphine in the mouse. Neurosci Lett. 2003 Apr 10; 340(2):103-6. Smith DJ, Leil TA, Liu X. PMID: 12668247.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    33. Genes regulated by learning in the hippocampus. J Neurosci Res. 2003 Mar 15; 71(6):763-8. Leil TA, Ossadtchi A, Nichols TE, Leahy RM, Smith DJ. PMID: 12605401.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    34. Error-correcting microarray design. Genomics. 2003 Feb; 81(2):157-65. Khan AH, Ossadtchi A, Leahy RM, Smith DJ. PMID: 12620393.
      View in: PubMed   Mentions: 2     Fields:    
    35. The allelic structure of common disease. Hum Mol Genet. 2002 Oct 01; 11(20):2455-61. Smith DJ, Lusis AJ. PMID: 12351581.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    36. Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease. Genome Res. 2002 Jun; 12(6):868-84. Brown VM, Ossadtchi A, Khan AH, Yee S, Lacan G, Melega WP, Cherry SR, Leahy RM, Smith DJ. PMID: 12045141; PMCID: PMC1383741.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    37. Finding new candidate genes for learning and memory. J Neurosci Res. 2002 Apr 15; 68(2):127-37. Leil TA, Ossadtchi A, Cortes JS, Leahy RM, Smith DJ. PMID: 11948658.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res. 2002 Mar 08; 90(4):458-64. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. PMID: 11884376.
      View in: PubMed   Mentions: 122     Fields:    Translation:AnimalsCells
    39. Gene expression tomography. Physiol Genomics. 2002 Feb 28; 8(2):159-67. Brown VM, Ossadtchi A, Khan AH, Gambhir SS, Cherry SR, Leahy RM, Smith DJ. PMID: 11875194.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    40. High-throughput imaging of brain gene expression. Genome Res. 2002 Feb; 12(2):244-54. Brown VM, Ossadtchi A, Khan AH, Cherry SR, Leahy RM, Smith DJ. PMID: 11827944.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    41. 'I can't go on, I'll go on' Drug Discov Today. 2001 Dec 01; 6(23):1198. Smith DJ. PMID: 11722869.
      View in: PubMed   Mentions:    Fields: