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Thomas A Drake

Title(s)Professor-in-Residence, Pathology and Laboratory Medicine
SchoolMedicine
Address760 Westwood Plaza A3-251
Los Angeles CA 90024
Phone56975
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    Collapse Research 
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    Gene expression networks for metabolic syndrome traits in mice
    NIH/NIDDK R01DK072206Apr 15, 2006 - Apr 14, 2012
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes. 2016 07 03; 7(4):313-322. Org E, Mehrabian M, Parks BW, Shipkova P, Liu X, Drake TA, Lusis AJ. PMID: 27355107.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    2. The pH of chemistry assays plays an important role in monoclonal immunoglobulin interferences. Pract Lab Med. 2015 Dec 01; 3:8-16. Alberti MO, Drake TA, Song L. PMID: 28932804.
      View in: PubMed   Mentions:
    3. Genetic and environmental control of host-gut microbiota interactions. Genome Res. 2015 Oct; 25(10):1558-69. Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis AJ. PMID: 26260972.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    4. Allele-specific expression and eQTL analysis in mouse adipose tissue. BMC Genomics. 2014 Jun 13; 15:471. Hasin-Brumshtein Y, Hormozdiari F, Martin L, van Nas A, Eskin E, Lusis AJ, Drake TA. PMID: 24927774.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    5. The systems genetics resource: a web application to mine global data for complex disease traits. Front Genet. 2013; 4:84. van Nas A, Pan C, Ingram-Drake LA, Ghazalpour A, Drake TA, Sobel EM, Papp JC, Lusis AJ. PMID: 23730305.
      View in: PubMed   Mentions:
    6. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24; 112(11):e152-3. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 23625949.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. Limited RNA editing in exons of mouse liver and adipose. Genetics. 2013 Apr; 193(4):1107-15. Lagarrigue S, Hormozdiari F, Martin LJ, Lecerf F, Hasin Y, Rau C, Hagopian R, Xiao Y, Yan J, Drake TA, Ghazalpour A, Eskin E, Lusis AJ. PMID: 23410828.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    8. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 2013 Jan 08; 17(1):141-52. Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake TA, Drevon CA, Knight R, Gargalovic P, Kirchgessner T, Eskin E, Lusis AJ. PMID: 23312289.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansAnimals
    9. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct; 23(9-10):680-92. Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. PMID: 22892838.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    10. ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17; 111(5):516-20. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. PMID: 22811557.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    11. Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arterioscler Thromb Vasc Biol. 2011 Dec; 31(12):2806-12. Mungrue IN, Zhao P, Yao Y, Meng H, Rau C, Havel JV, Gorgels TG, Bergen AA, MacLellan WR, Drake TA, Boström KI, Lusis AJ. PMID: 21979437.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    12. Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet. 2011 Apr; 7(4):e1002038. Farber CR, Bennett BJ, Orozco L, Zou W, Lira A, Kostem E, Kang HM, Furlotte N, Berberyan A, Ghazalpour A, Suwanwela J, Drake TA, Eskin E, Wang QT, Teitelbaum SL, Lusis AJ. PMID: 21490954.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    13. Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics. 2010 Jul; 185(3):1059-68. van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS, Schadt EE, Drake T, Lusis AJ. PMID: 20439777.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    14. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res. 2010 Feb; 20(2):281-90. Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis AJ. PMID: 20054062.
      View in: PubMed   Mentions: 160     Fields:    Translation:Animals
    15. Genes and pathways contributing to obesity: a systems biology view. Prog Mol Biol Transl Sci. 2010; 94:9-38. Drake TA. PMID: 21036321.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    16. Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice. Hum Mol Genet. 2010 Feb 15; 19(4):597-608. Wu S, Mar-Heyming R, Dugum EZ, Kolaitis NA, Qi H, Pajukanta P, Castellani LW, Lusis AJ, Drake TA. PMID: 19995791.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    17. Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet. 2009 Dec; 2(6):573-82. Wang SS, Martin LJ, Schadt EE, Meng H, Wang X, Zhao W, Ingram-Drake L, Nebohacova M, Mehrabian M, Drake TA, Lusis AJ. PMID: 20031637.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    18. Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 2009 Apr; 41(4):415-23. Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA. PMID: 19270708.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    19. An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. J Bone Miner Res. 2009 Jan; 24(1):105-16. Farber CR, van Nas A, Ghazalpour A, Aten JE, Doss S, Sos B, Schadt EE, Ingram-Drake L, Davis RC, Horvath S, Smith DJ, Drake TA, Lusis AJ. PMID: 18767929.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    20. A systems-based framework for understanding complex metabolic and cardiovascular disorders. J Lipid Res. 2009 Apr; 50 Suppl:S358-63. Wu S, Lusis AJ, Drake TA. PMID: 19033210.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One. 2008; 3(10):e3583. Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA. PMID: 18974833.
      View in: PubMed   Mentions: 258     Fields:    Translation:Humans
    22. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 2009 Mar; 150(3):1235-49. van Nas A, Guhathakurta D, Wang SS, Yehya N, Horvath S, Zhang B, Ingram-Drake L, Chaudhuri G, Schadt EE, Drake TA, Arnold AP, Lusis AJ. PMID: 18974276.
      View in: PubMed   Mentions: 93     Fields:    Translation:Animals
    23. High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS Genet. 2008 Aug 08; 4(8):e1000149. Ghazalpour A, Doss S, Kang H, Farber C, Wen PZ, Brozell A, Castellanos R, Eskin E, Smith DJ, Drake TA, Lusis AJ. PMID: 18688273.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    24. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 2008 May 06; 6(5):e107. Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R. PMID: 18462017.
      View in: PubMed   Mentions: 539     Fields:    Translation:HumansAnimalsCells
    25. Variations in DNA elucidate molecular networks that cause disease. Nature. 2008 Mar 27; 452(7186):429-35. Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE. PMID: 18344982.
      View in: PubMed   Mentions: 428     Fields:    Translation:AnimalsCells
    26. Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2671-6. Wang SS, Shi W, Wang X, Velky L, Greenlee S, Wang MT, Drake TA, Lusis AJ. PMID: 17916774.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    27. Weighted gene coexpression network analysis strategies applied to mouse weight. Mamm Genome. 2007 Jul; 18(6-7):463-72. Fuller TF, Ghazalpour A, Aten JE, Drake TA, Lusis AJ, Horvath S. PMID: 17668265.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    28. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res. 2007 Aug 03; 101(3):e11-30. Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis AJ. PMID: 17641228.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    29. A system for sharing routine surgical pathology specimens across institutions: the Shared Pathology Informatics Network. Hum Pathol. 2007 Aug; 38(8):1212-25. Drake TA, Braun J, Marchevsky A, Kohane IS, Fletcher C, Chueh H, Beckwith B, Berkowicz D, Kuo F, Zeng QT, Balis U, Holzbach A, McMurry A, Gee CE, McDonald CJ, Schadow G, Davis M, Hattab EM, Blevins L, Hook J, Becich M, Crowley RS, Taube SE, Berman J. PMID: 17490722.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    30. Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4530-5. Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis AJ. PMID: 17360558.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    31. Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Proteomics approaches to the systems biology of cardiovascular diseases. J Lipid Res. 2007 Jan; 48(1):1-8. Drake TA, Ping P. PMID: 17065662.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res. 2006 Aug; 16(8):995-1004. Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA, Lusis AJ. PMID: 16825664.
      View in: PubMed   Mentions: 326     Fields:    Translation:AnimalsCells
    33. Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet. 2006 Aug 18; 2(8):e130. Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S. PMID: 16934000.
      View in: PubMed   Mentions: 188     Fields:    Translation:Animals
    34. Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice. Mamm Genome. 2006 Jun; 17(6):466-79. Drake TA, Schadt EE, Lusis AJ. PMID: 16783628.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    35. Differential effects of two types of formative assessment in predicting performance of first-year medical students. Adv Health Sci Educ Theory Pract. 2006 May; 11(2):155-71. Krasne S, Wimmers PF, Relan A, Drake TA. PMID: 16729243.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet. 2006 Feb; 2(2):e15. Wang S, Yehya N, Schadt EE, Wang H, Drake TA, Lusis AJ. PMID: 16462940.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    37. Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice. Am J Ther. 2005 Nov-Dec; 12(6):503-11. Drake TA, Schadt EE, Davis RC, Lusis AJ. PMID: 16280644.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    38. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet. 2005 Nov; 37(11):1224-33. Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE. PMID: 16200066.
      View in: PubMed   Mentions: 101     Fields:    Translation:Animals
    39. Genomic analysis of metabolic pathway gene expression in mice. Genome Biol. 2005; 6(7):R59. Ghazalpour A, Doss S, Sheth SS, Ingram-Drake LA, Schadt EE, Lusis AJ, Drake TA. PMID: 15998448.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    40. An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet. 2005 Jul; 37(7):710-7. Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, Lum PY, Leonardson A, Thieringer R, Metzger JM, Yang L, Castle J, Zhu H, Kash SF, Drake TA, Sachs A, Lusis AJ. PMID: 15965475.
      View in: PubMed   Mentions: 432     Fields:    Translation:Animals
    41. Cis-acting expression quantitative trait loci in mice. Genome Res. 2005 May; 15(5):681-91. Doss S, Schadt EE, Drake TA, Lusis AJ. PMID: 15837804.
      View in: PubMed   Mentions: 143     Fields:    Translation:Animals
    42. Thematic review series: The pathogenesis of atherosclerosis. Toward a biological network for atherosclerosis. J Lipid Res. 2004 Oct; 45(10):1793-805. Ghazalpour A, Doss S, Yang X, Aten J, Toomey EM, Van Nas A, Wang S, Drake TA, Lusis AJ. PMID: 15292376.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    43. Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1901-6. Shi W, Brown MD, Wang X, Wong J, Kallmes DF, Matsumoto AH, Helm GA, Drake TA, Lusis AJ. PMID: 12920047.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    44. Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice. Mamm Genome. 2003 Jul; 14(7):464-71. Colinayo VV, Qiao JH, Wang X, Krass KL, Schadt E, Lusis AJ, Drake TA. PMID: 12925895.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    45. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiol Dis. 2003 Jul; 13(2):102-8. Krass KL, Colinayo V, Ghazalpour A, Vinters HV, Lusis AJ, Drake TA. PMID: 12828934.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    46. Genetics of gene expression surveyed in maize, mouse and man. Nature. 2003 Mar 20; 422(6929):297-302. Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, Friend SH. PMID: 12646919.
      View in: PubMed   Mentions: 590     Fields:    Translation:HumansAnimalsCells
    47. ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities. Crit Rev Oral Biol Med. 2003; 14(5):320-30. Nishimura I, Drake TA, Lusis AJ, Lyons KM, Nadeau JH, Zernik J. PMID: 14530301.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    48. Genetic characterization of the Dyscalc locus. Mamm Genome. 2002 Jun; 13(6):283-8. Colinayo VV, Qiao JH, Demant P, Krass K, Lusis AJ, Drake TA. PMID: 12115029.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    49. Genetic loci influencing natural variations in femoral bone morphometry in mice. J Orthop Res. 2001 Jul; 19(4):511-7. Drake TA, Hannani K, Kabo JM, Villa V, Krass K, Lusis AJ. PMID: 11518254.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    50. Genetic loci determining bone density in mice with diet-induced atherosclerosis. Physiol Genomics. 2001 Apr 27; 5(4):205-15. Drake TA, Schadt E, Hannani K, Kabo JM, Krass K, Colinayo V, Greaser LE, Goldin J, Lusis AJ. PMID: 11328966.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
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