Leonid Kruglyak

Title(s)Department Chair, Human Genetics
SchoolMedicine
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    Title(s)Professor, Human Genetics

    Title(s)Professor, Biological Chemistry


    Collapse Overview 
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    Leonid Kruglyak, Ph.D., holds The Diller-von Furstenberg Family Endowed Chair in Human Genetics.

    Collapse Research 
    Collapse research activities and funding
    High-throughput identification of causal variants underlying quantitative traits in yeast
    NIH R01GM102308Sep 1, 2012 - Apr 30, 2023
    Role: Principal Investigator
    Genetic dissection of complex traits in C. elegans
    NIH R01HG004321Aug 16, 2007 - May 31, 2018
    Role: Principal Investigator
    UW-FHCRC Variation Discovery Resource
    NIH U01HL066642Sep 30, 2000 - Jul 31, 2010
    Role: Co-Principal Investigator
    Quantitative Methods for Linkage and Associated Studies
    NIH R37MH059520Dec 1, 1998 - Nov 30, 2012
    Role: Principal Investigator
    QUANTITATIVE METHODS FOR LINKAGE AND ASSOCIATION STUDIES
    NIH R01MH059520Dec 1, 1998 - Nov 30, 2001
    Role: Principal Investigator
    MATHEMATICAL AND COMPUTATIONAL ISSUES IN GENOME ANALYSIS
    NIH K01HG000017Dec 1, 1994 - Nov 30, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Faster genetic mapping of complex traits in C. elegans. MicroPubl Biol. 2025; 2025. Zdraljevic S, Walter-McNeill L, Lee A, Bloom J, Kruglyak L. PMID: 40342920; PMCID: PMC12059802.
      View in: PubMed   Mentions:
    2. Regeneration leads to global tissue rejuvenation in aging sexual planarians. Nat Aging. 2025 Apr 03. Dai X, Li X, Tyshkovskiy A, Zuckerman C, Cheng N, Lin P, Paris D, Qureshi S, Kruglyak L, Mao X, Nandakumar J, Gladyshev VN, Pletcher S, Sobota J, Guo L. PMID: 40181188.
      View in: PubMed   Mentions:
    3. Mixed, not stirred: Genomic data confirm the first case of interspecific hybridization in planarian triclads (Platyhelminthes: Tricladida) and raise questions about a possibly novel form of hybrid speciation. Mol Phylogenet Evol. 2025 Jun; 207:108339. Dols-Serrate D, Guo L, Kruglyak L, Riutort M. PMID: 40132772.
      View in: PubMed   Mentions:
    4. Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction. Elife. 2025 Mar 12; 13. Boocock J, Alexander N, Alamo Tapia L, Walter-McNeill L, Patel SP, Munugala C, Bloom JS, Kruglyak L. PMID: 40073070; PMCID: PMC11903034.
      View in: PubMed   Mentions:
    5. Divergent C. elegans toxin alleles are suppressed by distinct mechanisms. bioRxiv. 2024 Nov 20. Zdraljevic S, Walter-McNeill L, Bruni GN, Bloom JS, Leighton DHW, Collins JB, Marquez H, Alexander N, Kruglyak L. PMID: 39605437; PMCID: PMC11601442.
      View in: PubMed   Mentions: 1  
    6. Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction. bioRxiv. 2024 Nov 08. Boocock J, Alexander N, Tapia LA, Walter-McNeill L, Patel SP, Munugala C, Bloom JS, Kruglyak L. PMID: 38106186; PMCID: PMC10723400.
      View in: PubMed   Mentions:
    7. Accurate Prediction of Children's Target Height from Their Mid-Parental Height. Children (Basel). 2024 Jul 30; 11(8). Zeevi D, Ben Yehuda A, Nathan D, Zangen D, Kruglyak L. PMID: 39201851; PMCID: PMC11352326.
      View in: PubMed   Mentions: 1  
    8. Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos. Physiol Genomics. 2023 11 01; 55(11):479-486. Guo L, Kruglyak L. PMID: 37642275.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Insufficient evidence for non-neutrality of synonymous mutations. Nature. 2023 04; 616(7957):E8-E9. Kruglyak L, Beyer A, Bloom JS, Grossbach J, Lieberman TD, Mancuso CP, Rich MS, Sherlock G, Kaplan CD. PMID: 37076734; PMCID: PMC11343442.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    10. Heritable Cas9-induced nonhomologous recombination in C. elegans. MicroPubl Biol. 2023; 2023. Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. PMID: 36879982; PMCID: PMC9984945.
      View in: PubMed   Mentions: 3  
    11. Cas9-induced nonhomologous recombination in C. elegans. bioRxiv. 2023 Jan 20. Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. PMID: 36711988; PMCID: PMC9882370.
      View in: PubMed   Mentions:
    12. Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications. PLoS Biol. 2022 12; 20(12):e3001911. Swichkow CR, Bloom JS, Kruglyak L. PMID: 36525401; PMCID: PMC9757564.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. A minimal role for synonymous variation in human disease. Am J Hum Genet. 2022 12 01; 109(12):2105-2109. Dhindsa RS, Wang Q, Vitsios D, Burren OS, Hu F, DiCarlo JE, Kruglyak L, MacArthur DG, Hurles ME, Petrovski S. PMID: 36459978; PMCID: PMC9808499.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    14. Genome-wide base editor screen identifies regulators of protein abundance in yeast. Elife. 2022 Nov 03; 11. Schubert OT, Bloom JS, Sadhu MJ, Kruglyak L. PMID: 36326816; PMCID: PMC9633064.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    15. Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression. Microb Cell Fact. 2022 Jun 18; 21(1):119. Brandenberg OF, Schubert OT, Kruglyak L. PMID: 35717313; PMCID: PMC9206389.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    16. Island-specific evolution of a sex-primed autosome in a sexual planarian. Nature. 2022 06; 606(7913):329-334. Guo L, Bloom JS, Dols-Serrate D, Boocock J, Ben-David E, Schubert OT, Kozuma K, Ho K, Warda E, Chui C, Wei Y, Leighton D, Lemus Vergara T, Riutort M, Sánchez Alvarado A, Kruglyak L. PMID: 35650439; PMCID: PMC9177419.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    17. Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA. BMC Genomics. 2022 Apr 04; 23(1):260. Guo L, Boocock J, Hilt EE, Chandrasekaran S, Zhang Y, Munugala C, Sathe L, Alexander N, Arboleda VA, Flint J, Eskin E, Luo C, Yang S, Garner OB, Yin Y, Bloom JS, Kruglyak L. PMID: 35379194; PMCID: PMC8978495.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    18. Retrospective Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California. Clin Infect Dis. 2022 01 29; 74(2):271-277. Hilt EE, Boocock J, Trejo M, Le CQ, Guo L, Zhang Y, Sathe L, Arboleda VA, Yin Y, Bloom JS, Wang PC, Elmore JG, Kruglyak L, Shrestha L, Bakhash SAM, Lin M, Xie H, Huang ML, Roychoudhury P, Greninger A, Chandrasekaran S, Yang S, Garner OB. PMID: 33939799; PMCID: PMC8135745.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California. Open Forum Infect Dis. 2021 Nov; 8(11):ofab526. Adamson PC, Pfeffer MA, Arboleda VA, Garner OB, de St Maurice A, von Bredow B, Flint J, Kruglyak L, Currier JS. PMID: 35005055; PMCID: PMC8689969.
      View in: PubMed   Mentions: 2  
    20. Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining. J Vis Exp. 2021 09 10; (175). Guo F, McClain M, Zhao X, Yi K, Parmely T, Unruh J, Slaughter B, Kruglyak L, Guo L, Sánchez Alvarado A. PMID: 34570108.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nat Biomed Eng. 2021 07; 5(7):657-665. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 34211145; PMCID: PMC10810734.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    22. Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos. PLoS Genet. 2021 06; 17(6):e1009580. Guo L, Bloom J, Sykes S, Huang E, Kashif Z, Pham E, Ho K, Alcaraz A, Xiao XG, Duarte-Vogel S, Kruglyak L. PMID: 34166378; PMCID: PMC8224956.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    23. Whole-organism eQTL mapping at cellular resolution with single-cell sequencing. Elife. 2021 03 18; 10. Ben-David E, Boocock J, Guo L, Zdraljevic S, Bloom JS, Kruglyak L. PMID: 33734084; PMCID: PMC8062134.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    24. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv. 2021 Mar 09. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 32909008; PMCID: PMC7480060.
      View in: PubMed   Mentions: 2  
    25. Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast. Science. 2021 01 22; 371(6527):415-419. Boocock J, Sadhu MJ, Durvasula A, Bloom JS, Kruglyak L. PMID: 33479156; PMCID: PMC8384573.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    26. Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species. Curr Biol. 2021 03 08; 31(5):990-1001.e5. Ben-David E, Pliota P, Widen SA, Koreshova A, Lemus-Vergara T, Verpukhovskiy P, Mandali S, Braendle C, Burga A, Kruglyak L. PMID: 33417886.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    27. Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross. Elife. 2020 11 12; 9. Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW. PMID: 33179598; PMCID: PMC7685706.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Toxin-Antidote Elements Across the Tree of Life. Annu Rev Genet. 2020 11 23; 54:387-415. Burga A, Ben-David E, Kruglyak L. PMID: 32886546.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell. 2019 11 27; 179(6):1424-1435.e8. Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. PMID: 31761530; PMCID: PMC6957074.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    30. Rare variants contribute disproportionately to quantitative trait variation in yeast. Elife. 2019 10 24; 8. Bloom JS, Boocock J, Treusch S, Sadhu MJ, Day L, Oates-Barker H, Kruglyak L. PMID: 31647408; PMCID: PMC6892613.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    31. Analysis of the genetic basis of height in large Jewish nuclear families. PLoS Genet. 2019 07; 15(7):e1008082. Zeevi D, Bloom JS, Sadhu MJ, Ben Yehuda A, Zangen D, Levy-Lahad E, Kruglyak L. PMID: 31283753; PMCID: PMC6638967.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nat Commun. 2019 06 18; 10(1):2680. Burga A, Ben-David E, Lemus Vergara T, Boocock J, Kruglyak L. PMID: 31213597; PMCID: PMC6582151.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    33. The Genetic Basis of Mutation Rate Variation in Yeast. Genetics. 2019 02; 211(2):731-740. Gou L, Bloom JS, Kruglyak L. PMID: 30504363; PMCID: PMC6366923.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    34. How Low Can You Go? CRISPR J. 2018 10; 1:312-313. Sadhu MJ, Kruglyak L. PMID: 31021269.
      View in: PubMed   Mentions: 1     Fields:    
    35. Genetics of trans-regulatory variation in gene expression. Elife. 2018 07 17; 7. Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L. PMID: 30014850; PMCID: PMC6072440.
      View in: PubMed   Mentions: 100     Fields:    Translation:Animals
    36. Highly parallel genome variant engineering with CRISPR-Cas9. Nat Genet. 2018 Apr; 50(4):510-514. Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L. PMID: 29632376; PMCID: PMC6115196.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    37. The genetic basis of natural variation in a phoretic behavior. Nat Commun. 2017 08 17; 8(1):273. Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J. PMID: 28819099; PMCID: PMC5561207.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    38. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 2017 08 17; 6. Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. PMID: 28826486; PMCID: PMC5580887.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    39. A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017 Jun 02; 356(6341). Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. PMID: 28572335; PMCID: PMC5567675.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    40. A maternal-effect selfish genetic element in Caenorhabditis elegans. Science. 2017 06 09; 356(6342):1051-1055. Ben-David E, Burga A, Kruglyak L. PMID: 28495877; PMCID: PMC6251971.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    41. Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. Nat Genet. 2017 Apr; 49(4):497-503. Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö. PMID: 28250458; PMCID: PMC5459553.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    42. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics. 2016 09; 204(1):371-83. Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. PMID: 27449056; PMCID: PMC5012401.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    43. Complex Traits and Simple Systems: An Interview with Leonid Kruglyak. Genetics. 2016 Jul; 203(3):1023-5. Kruglyak L. PMID: 27384025; PMCID: PMC4937462.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    44. CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science. 2016 May 27; 352(6289):1113-6. Sadhu MJ, Bloom JS, Day L, Kruglyak L. PMID: 27230379; PMCID: PMC4933295.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    45. 2015 Curt Stern Award. Am J Hum Genet. 2016 Mar 03; 98(3):428-430. Kruglyak L. PMID: 26942280; PMCID: PMC4800031.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nat Commun. 2015 Nov 05; 6:8712. Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L. PMID: 26537231; PMCID: PMC4635962.
      View in: PubMed   Mentions: 84     Fields:    Translation:Animals
    47. Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics. 2015 Aug; 200(4):1327-39. Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L. PMID: 26092720; PMCID: PMC4574258.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    48. Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics. 2015 Jul; 200(3):975-89. Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, Waterston RH. PMID: 25995208; PMCID: PMC4512556.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    49. Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis. Genome Res. 2015 May; 25(5):667-78. Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD. PMID: 25783854; PMCID: PMC4417115.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    50. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. G3 (Bethesda). 2015 Mar 13; 5(5):911-20. Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L. PMID: 25770127; PMCID: PMC4426375.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    51. The role of regulatory variation in complex traits and disease. Nat Rev Genet. 2015 Apr; 16(4):197-212. Albert FW, Kruglyak L. PMID: 25707927.
      View in: PubMed   Mentions: 527     Fields:    Translation:Humans
    52. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. PLoS Pathog. 2015 Feb; 11(2):e1004583. Balla KM, Andersen EC, Kruglyak L, Troemel ER. PMID: 25680197; PMCID: PMC4334554.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    53. Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae. PLoS Genet. 2015 Jan; 11(1):e1004913. Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L. PMID: 25569670; PMCID: PMC4287466.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    54. Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. PLoS Genet. 2014 Dec; 10(12):e1004894. Wang X, Kruglyak L. PMID: 25521586; PMCID: PMC4270474.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    55. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. Albert FW, Muzzey D, Weissman JS, Kruglyak L. PMID: 25340754; PMCID: PMC4207643.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    56. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics. 2014 Nov; 198(3):1277-90. Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW. PMID: 25189874; PMCID: PMC4224166.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    57. Genetic basis of metabolome variation in yeast. PLoS Genet. 2014 Mar; 10(3):e1004142. Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. PMID: 24603560; PMCID: PMC3945093.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    58. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. PLoS Genet. 2014 Feb; 10(2):e1004156. Andersen EC, Bloom JS, Gerke JP, Kruglyak L. PMID: 24586193; PMCID: PMC3937155.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    59. Genetics of single-cell protein abundance variation in large yeast populations. Nature. 2014 Feb 27; 506(7489):494-7. Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L. PMID: 24402228; PMCID: PMC4285441.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    60. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda). 2013 04 09; 3(4):733-740. Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess DC. PMID: 23550140; PMCID: PMC3618360.
      View in: PubMed   Mentions: 7     Fields:    
    61. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet. 2013; 9(3):e1003329. Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. PMID: 23505383; PMCID: PMC3591295.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    62. Finding the sources of missing heritability in a yeast cross. Nature. 2013 Feb 14; 494(7436):234-7. Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L. PMID: 23376951; PMCID: PMC4001867.
      View in: PubMed   Mentions: 254     Fields:    Translation:HumansAnimals
    63. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet. 2012; 8(12):e1003157. Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. PMID: 23284308; PMCID: PMC3527333.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    64. Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol. 2012 Oct 31; 10:85. Ghosh R, Mohammadi A, Kruglyak L, Ryu WS. PMID: 23114012; PMCID: PMC3520762.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    65. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 2012 Dec; 192(4):1533-42. Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC. PMID: 23086219; PMCID: PMC3512158.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    66. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science. 2012 Jul 27; 337(6093):470-3. Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. PMID: 22773140; PMCID: PMC3845625.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
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    145. Unleashing the canine genome. Genome Res. 2000 Sep; 10(9):1271-4. Ostrander EA, Kruglyak L. PMID: 10984444.
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    146. Precise gene localization by phenotypic assay of radiation hybrid cells. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7388-92. Rasko JE, Battini JL, Kruglyak L, Cox DR, Miller AD. PMID: 10852967; PMCID: PMC16555.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    147. No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. Am J Med Genet. 2000 Apr 03; 96(2):224-7. Nancarrow DJ, Levinson DF, Taylor JM, Hayward NK, Walters MK, Lennon DP, Nertney DA, Jones HL, Mahtani MM, Kirby A, Kruglyak L, Brown DM, Crowe RR, Andreasen NC, Black DW, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Mowry BJ. PMID: 10893501.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    148. Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet. 2000 Mar; 66(3):1153-7. Pratt SC, Daly MJ, Kruglyak L. PMID: 10712227; PMCID: PMC1288151.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    149. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am J Hum Genet. 2000 Jan; 66(1):205-15. Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, McInnis M, Simpson S, McMahon F, Stine OC, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, Folstein S, Daly M, Kruglyak L, Marr T, DePaulo JR, Botstein D. PMID: 10631152; PMCID: PMC1288327.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    150. An analysis of strategies for discovery of single-nucleotide polymorphisms. Genet Epidemiol. 2000; 19 Suppl 1:S29-35. Eberle MA, Kruglyak L. PMID: 11055367.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    151. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999 Jun; 22(2):139-44. Kruglyak L. PMID: 10369254.
      View in: PubMed   Mentions: 319     Fields:    Translation:Humans
    152. Genetic isolates: separate but equal? Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1170-2. Kruglyak L. PMID: 9989995; PMCID: PMC33550.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    153. Genome scan of schizophrenia. Am J Psychiatry. 1998 Jun; 155(6):741-50. Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, Walters MK, Lennon DP, Jones HL, Nertney DA, Daly MJ, Gladis M, Mowry BJ. PMID: 9619145.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    154. Genetic polymorphisms and disease. N Engl J Med. 1998 May 28; 338(22):1626. Altshuler D, Kruglyak L, Lander E. PMID: 9606122.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    155. Siblings of centenarians live longer. Lancet. 1998 May 23; 351(9115):1560. Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. PMID: 10326548.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    156. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 1998 May 15; 280(5366):1077-82. Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES. PMID: 9582121.
      View in: PubMed   Mentions: 467     Fields:    Translation:HumansCells
    157. Linkage thresholds for two-stage genome scans. Am J Hum Genet. 1998 Apr; 62(4):994-7. Kruglyak L, Daly MJ. PMID: 9529350; PMCID: PMC1377032.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    158. Who needs genetic markers? Nat Genet. 1998 Mar; 18(3):200-2. Kruglyak L, McAllister L. PMID: 9500532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    159. Faster multipoint linkage analysis using Fourier transforms. J Comput Biol. 1998; 5(1):1-7. Kruglyak L, Lander ES. PMID: 9541867.
      View in: PubMed   Mentions: 57     Fields:    Translation:Humans
    160. Sib-pair collection strategies for complex diseases. Genet Epidemiol. 1998; 15(4):317-40. McCarthy MI, Kruglyak L, Lander ES. PMID: 9671984.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    161. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet. 1997 Nov; 6(12):2069-76. Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. PMID: 9328470.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    162. What is significant in whole-genome linkage disequilibrium studies? Am J Hum Genet. 1997 Oct; 61(4):810-2. Kruglyak L. PMID: 9382090; PMCID: PMC1715992.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    163. The use of a genetic map of biallelic markers in linkage studies. Nat Genet. 1997 Sep; 17(1):21-4. Kruglyak L. PMID: 9288093.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    164. Nonparametric linkage tests are model free. Am J Hum Genet. 1997 Jul; 61(1):254-5. Kruglyak L. PMID: 9246012; PMCID: PMC1715868.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    165. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May; 18(5):711-22. Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. PMID: 9182797.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    166. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):587-92. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W. PMID: 9012828; PMCID: PMC19557.
      View in: PubMed   Mentions: 271     Fields:    Translation:HumansCells
    167. Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? Genet Epidemiol. 1997; 14(6):599-604. Daly M, Kirby A, Kruglyak L. PMID: 9433549.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    168. Building human genome maps with radiation hybrids. J Comput Biol. 1997; 4(4):487-504. Slonim D, Kruglyak L, Stein L, Lander E. PMID: 9385541.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    169. Thresholds and sample sizes. Nat Genet. 1996 Oct; 14(2):132-3. Kruglyak L. PMID: 8841180.
      View in: PubMed   Mentions: 5     Fields:    
    170. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet. 1996 Sep; 14(1):90-4. Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC. PMID: 8782826.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    171. A locus for Fanconi anemia on 16q determined by homozygosity mapping. Am J Hum Genet. 1996 Aug; 59(2):377-84. Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. PMID: 8755924; PMCID: PMC1914713.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    172. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996 Jun; 58(6):1347-63. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. PMID: 8651312; PMCID: PMC1915045.
      View in: PubMed   Mentions: 829     Fields:    Translation:Humans
    173. Limits on fine mapping of complex traits. Am J Hum Genet. 1996 May; 58(5):1092-3. Kruglyak L, Lander ES. PMID: 8651271; PMCID: PMC1914627.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    174. Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246. Am J Hum Genet. 1996 Mar; 58(3):523-34. Levy EN, Shen Y, Kupelian A, Kruglyak L, Aksentijevich I, Pras E, Balow JE, Linzer B, Chen X, Shelton DA, Gumucio D, Pras M, Shohat M, Rotter JI, Fischel-Ghodsian N, Richards RI, Kastner DL. PMID: 8644712; PMCID: PMC1914560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    175. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22; 379(6567):736-9. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. PMID: 8602221.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
    176. An STS-based map of the human genome. Science. 1995 Dec 22; 270(5244):1945-54. Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Fauré S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES. PMID: 8533086.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    177. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995 Nov; 11(3):241-7. Lander E, Kruglyak L. PMID: 7581446.
      View in: PubMed   Mentions: 1423     Fields:    
    178. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat Genet. 1995 Nov; 11(3):248-56. Hu S, Pattatucci AM, Patterson C, Li L, Fulker DW, Cherny SS, Kruglyak L, Hamer DH. PMID: 7581447.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    179. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 1995 Aug; 57(2):439-54. Kruglyak L, Lander ES. PMID: 7668271; PMCID: PMC1801561.
      View in: PubMed   Mentions: 196     Fields:    Translation:Humans
    180. High-resolution genetic mapping of complex traits. Am J Hum Genet. 1995 May; 56(5):1212-23. Kruglyak L, Lander ES. PMID: 7726179; PMCID: PMC1801437.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    181. A nonparametric approach for mapping quantitative trait loci. Genetics. 1995 Mar; 139(3):1421-8. Kruglyak L, Lander ES. PMID: 7768449; PMCID: PMC1206467.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    182. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet. 1995 Feb; 56(2):519-27. Kruglyak L, Daly MJ, Lander ES. PMID: 7847388; PMCID: PMC1801139.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    183. Sexual orientation. Nature. 1993 Oct 21; 365(6448):702. Kruglyak L. PMID: 8413649.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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