Leonid Kruglyak

Title(s)Department Chair, Human Genetics
SchoolMedicine
vCardDownload vCard
    Other Positions
    Title(s)Professor, Human Genetics

    Title(s)Professor, Biological Chemistry


    Collapse Overview 
    Collapse overview
    Leonid Kruglyak, Ph.D., holds The Diller-von Furstenberg Family Endowed Chair in Human Genetics.

    Collapse Research 
    Collapse research activities and funding
    High-throughput identification of causal variants underlying quantitative traits in yeast
    NIH R01GM102308Sep 1, 2012 - Apr 30, 2023
    Role: Principal Investigator
    Genetic dissection of complex traits in C. elegans
    NIH R01HG004321Aug 16, 2007 - May 31, 2018
    Role: Principal Investigator
    UW-FHCRC Variation Discovery Resource
    NIH U01HL066642Sep 30, 2000 - Jul 31, 2010
    Role: Co-Principal Investigator
    Quantitative Methods for Linkage and Associated Studies
    NIH R37MH059520Dec 1, 1998 - Nov 30, 2012
    Role: Principal Investigator
    QUANTITATIVE METHODS FOR LINKAGE AND ASSOCIATION STUDIES
    NIH R01MH059520Dec 1, 1998 - Nov 30, 2001
    Role: Principal Investigator
    MATHEMATICAL AND COMPUTATIONAL ISSUES IN GENOME ANALYSIS
    NIH K01HG000017Dec 1, 1994 - Nov 30, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Divergent C. elegans toxin alleles are suppressed by distinct mechanisms. bioRxiv. 2024 Nov 20. Zdraljevic S, Walter-McNeill L, Bruni GN, Bloom JS, Leighton DHW, Collins JB, Marquez H, Alexander N, Kruglyak L. PMID: 39605437; PMCID: PMC11601442.
      View in: PubMed   Mentions:
    2. Single-cell eQTL mapping in yeast reveals a tradeoff between growth and reproduction. bioRxiv. 2024 Nov 08. Boocock J, Alexander N, Tapia LA, Walter-McNeill L, Patel SP, Munugala C, Bloom JS, Kruglyak L. PMID: 38106186; PMCID: PMC10723400.
      View in: PubMed   Mentions:
    3. Accurate Prediction of Children's Target Height from Their Mid-Parental Height. Children (Basel). 2024 Jul 30; 11(8). Zeevi D, Ben Yehuda A, Nathan D, Zangen D, Kruglyak L. PMID: 39201851; PMCID: PMC11352326.
      View in: PubMed   Mentions:
    4. Genetics and biology of coloration in reptiles: the curious case of the Lemon Frost geckos. Physiol Genomics. 2023 11 01; 55(11):479-486. Guo L, Kruglyak L. PMID: 37642275.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. Insufficient evidence for non-neutrality of synonymous mutations. Nature. 2023 04; 616(7957):E8-E9. Kruglyak L, Beyer A, Bloom JS, Grossbach J, Lieberman TD, Mancuso CP, Rich MS, Sherlock G, Kaplan CD. PMID: 37076734; PMCID: PMC11343442.
      View in: PubMed   Mentions: 6     Fields:    
    6. Heritable Cas9-induced nonhomologous recombination in C. elegans. MicroPubl Biol. 2023; 2023. Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. PMID: 36879982; PMCID: PMC9984945.
      View in: PubMed   Mentions: 3  
    7. Cas9-induced nonhomologous recombination in C. elegans. bioRxiv. 2023 Jan 20. Zdraljevic S, Walter-McNeill L, Marquez H, Kruglyak L. PMID: 36711988; PMCID: PMC9882370.
      View in: PubMed   Mentions:
    8. Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications. PLoS Biol. 2022 12; 20(12):e3001911. Swichkow CR, Bloom JS, Kruglyak L. PMID: 36525401; PMCID: PMC9757564.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    9. A minimal role for synonymous variation in human disease. Am J Hum Genet. 2022 12 01; 109(12):2105-2109. Dhindsa RS, Wang Q, Vitsios D, Burren OS, Hu F, DiCarlo JE, Kruglyak L, MacArthur DG, Hurles ME, Petrovski S. PMID: 36459978; PMCID: PMC9808499.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    10. Genome-wide base editor screen identifies regulators of protein abundance in yeast. Elife. 2022 Nov 03; 11. Schubert OT, Bloom JS, Sadhu MJ, Kruglyak L. PMID: 36326816; PMCID: PMC9633064.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    11. Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression. Microb Cell Fact. 2022 Jun 18; 21(1):119. Brandenberg OF, Schubert OT, Kruglyak L. PMID: 35717313; PMCID: PMC9206389.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    12. Island-specific evolution of a sex-primed autosome in a sexual planarian. Nature. 2022 06; 606(7913):329-334. Guo L, Bloom JS, Dols-Serrate D, Boocock J, Ben-David E, Schubert OT, Kozuma K, Ho K, Warda E, Chui C, Wei Y, Leighton D, Lemus Vergara T, Riutort M, Sánchez Alvarado A, Kruglyak L. PMID: 35650439; PMCID: PMC9177419.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA. BMC Genomics. 2022 Apr 04; 23(1):260. Guo L, Boocock J, Hilt EE, Chandrasekaran S, Zhang Y, Munugala C, Sathe L, Alexander N, Arboleda VA, Flint J, Eskin E, Luo C, Yang S, Garner OB, Yin Y, Bloom JS, Kruglyak L. PMID: 35379194; PMCID: PMC8978495.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    14. Retrospective Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California. Clin Infect Dis. 2022 01 29; 74(2):271-277. Hilt EE, Boocock J, Trejo M, Le CQ, Guo L, Zhang Y, Sathe L, Arboleda VA, Yin Y, Bloom JS, Wang PC, Elmore JG, Kruglyak L, Shrestha L, Bakhash SAM, Lin M, Xie H, Huang ML, Roychoudhury P, Greninger A, Chandrasekaran S, Yang S, Garner OB. PMID: 33939799; PMCID: PMC8135745.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California. Open Forum Infect Dis. 2021 Nov; 8(11):ofab526. Adamson PC, Pfeffer MA, Arboleda VA, Garner OB, de St Maurice A, von Bredow B, Flint J, Kruglyak L, Currier JS. PMID: 35005055; PMCID: PMC8689969.
      View in: PubMed   Mentions: 2  
    16. Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining. J Vis Exp. 2021 09 10; (175). Guo F, McClain M, Zhao X, Yi K, Parmely T, Unruh J, Slaughter B, Kruglyak L, Guo L, Sánchez Alvarado A. PMID: 34570108.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    17. Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples. Nat Biomed Eng. 2021 07; 5(7):657-665. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Sina Booeshaghi A, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 34211145; PMCID: PMC10810734.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    18. Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos. PLoS Genet. 2021 06; 17(6):e1009580. Guo L, Bloom J, Sykes S, Huang E, Kashif Z, Pham E, Ho K, Alcaraz A, Xiao XG, Duarte-Vogel S, Kruglyak L. PMID: 34166378; PMCID: PMC8224956.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    19. Whole-organism eQTL mapping at cellular resolution with single-cell sequencing. Elife. 2021 03 18; 10. Ben-David E, Boocock J, Guo L, Zdraljevic S, Bloom JS, Kruglyak L. PMID: 33734084; PMCID: PMC8062134.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    20. Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing. medRxiv. 2021 Mar 09. Bloom JS, Sathe L, Munugala C, Jones EM, Gasperini M, Lubock NB, Yarza F, Thompson EM, Kovary KM, Park J, Marquette D, Kay S, Lucas M, Love T, Booeshaghi AS, Brandenberg OF, Guo L, Boocock J, Hochman M, Simpkins SW, Lin I, LaPierre N, Hong D, Zhang Y, Oland G, Choe BJ, Chandrasekaran S, Hilt EE, Butte MJ, Damoiseaux R, Kravit C, Cooper AR, Yin Y, Pachter L, Garner OB, Flint J, Eskin E, Luo C, Kosuri S, Kruglyak L, Arboleda VA. PMID: 32909008; PMCID: PMC7480060.
      View in: PubMed   Mentions: 2  
    21. Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast. Science. 2021 01 22; 371(6527):415-419. Boocock J, Sadhu MJ, Durvasula A, Bloom JS, Kruglyak L. PMID: 33479156; PMCID: PMC8384573.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    22. Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species. Curr Biol. 2021 03 08; 31(5):990-1001.e5. Ben-David E, Pliota P, Widen SA, Koreshova A, Lemus-Vergara T, Verpukhovskiy P, Mandali S, Braendle C, Burga A, Kruglyak L. PMID: 33417886.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross. Elife. 2020 11 12; 9. Renganaath K, Chong R, Day L, Kosuri S, Kruglyak L, Albert FW. PMID: 33179598; PMCID: PMC7685706.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. Toxin-Antidote Elements Across the Tree of Life. Annu Rev Genet. 2020 11 23; 54:387-415. Burga A, Ben-David E, Kruglyak L. PMID: 32886546.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell. 2019 11 27; 179(6):1424-1435.e8. Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. PMID: 31761530; PMCID: PMC6957074.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    26. Rare variants contribute disproportionately to quantitative trait variation in yeast. Elife. 2019 10 24; 8. Bloom JS, Boocock J, Treusch S, Sadhu MJ, Day L, Oates-Barker H, Kruglyak L. PMID: 31647408; PMCID: PMC6892613.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    27. Analysis of the genetic basis of height in large Jewish nuclear families. PLoS Genet. 2019 07; 15(7):e1008082. Zeevi D, Bloom JS, Sadhu MJ, Ben Yehuda A, Zangen D, Levy-Lahad E, Kruglyak L. PMID: 31283753; PMCID: PMC6638967.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nat Commun. 2019 06 18; 10(1):2680. Burga A, Ben-David E, Lemus Vergara T, Boocock J, Kruglyak L. PMID: 31213597; PMCID: PMC6582151.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    29. The Genetic Basis of Mutation Rate Variation in Yeast. Genetics. 2019 02; 211(2):731-740. Gou L, Bloom JS, Kruglyak L. PMID: 30504363; PMCID: PMC6366923.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    30. How Low Can You Go? CRISPR J. 2018 10; 1:312-313. Sadhu MJ, Kruglyak L. PMID: 31021269.
      View in: PubMed   Mentions: 1     Fields:    
    31. Genetics of trans-regulatory variation in gene expression. Elife. 2018 07 17; 7. Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L. PMID: 30014850; PMCID: PMC6072440.
      View in: PubMed   Mentions: 94     Fields:    Translation:Animals
    32. Highly parallel genome variant engineering with CRISPR-Cas9. Nat Genet. 2018 Apr; 50(4):510-514. Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L. PMID: 29632376; PMCID: PMC6115196.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    33. The genetic basis of natural variation in a phoretic behavior. Nat Commun. 2017 08 17; 8(1):273. Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J. PMID: 28819099; PMCID: PMC5561207.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    34. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 2017 08 17; 6. Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. PMID: 28826486; PMCID: PMC5580887.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    35. A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017 Jun 02; 356(6341). Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. PMID: 28572335; PMCID: PMC5567675.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    36. A maternal-effect selfish genetic element in Caenorhabditis elegans. Science. 2017 06 09; 356(6342):1051-1055. Ben-David E, Burga A, Kruglyak L. PMID: 28495877; PMCID: PMC6251971.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    37. Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. Nat Genet. 2017 Apr; 49(4):497-503. Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö. PMID: 28250458; PMCID: PMC5459553.
      View in: PubMed   Mentions: 64     Fields:    Translation:Animals
    38. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics. 2016 09; 204(1):371-83. Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. PMID: 27449056; PMCID: PMC5012401.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    39. Complex Traits and Simple Systems: An Interview with Leonid Kruglyak. Genetics. 2016 Jul; 203(3):1023-5. Kruglyak L. PMID: 27384025; PMCID: PMC4937462.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    40. CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science. 2016 May 27; 352(6289):1113-6. Sadhu MJ, Bloom JS, Day L, Kruglyak L. PMID: 27230379; PMCID: PMC4933295.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    41. 2015 Curt Stern Award. Am J Hum Genet. 2016 Mar 03; 98(3):428-430. Kruglyak L. PMID: 26942280; PMCID: PMC4800031.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nat Commun. 2015 Nov 05; 6:8712. Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L. PMID: 26537231; PMCID: PMC4635962.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals
    43. Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics. 2015 Aug; 200(4):1327-39. Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L. PMID: 26092720; PMCID: PMC4574258.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    44. Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics. 2015 Jul; 200(3):975-89. Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, Waterston RH. PMID: 25995208; PMCID: PMC4512556.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    45. Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis. Genome Res. 2015 May; 25(5):667-78. Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD. PMID: 25783854; PMCID: PMC4417115.
      View in: PubMed   Mentions: 53     Fields:    Translation:Animals
    46. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. G3 (Bethesda). 2015 Mar 13; 5(5):911-20. Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L. PMID: 25770127; PMCID: PMC4426375.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    47. The role of regulatory variation in complex traits and disease. Nat Rev Genet. 2015 Apr; 16(4):197-212. Albert FW, Kruglyak L. PMID: 25707927.
      View in: PubMed   Mentions: 506     Fields:    Translation:Humans
    48. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. PLoS Pathog. 2015 Feb; 11(2):e1004583. Balla KM, Andersen EC, Kruglyak L, Troemel ER. PMID: 25680197; PMCID: PMC4334554.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    49. Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae. PLoS Genet. 2015 Jan; 11(1):e1004913. Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L. PMID: 25569670; PMCID: PMC4287466.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    50. Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. PLoS Genet. 2014 Dec; 10(12):e1004894. Wang X, Kruglyak L. PMID: 25521586; PMCID: PMC4270474.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    51. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. Albert FW, Muzzey D, Weissman JS, Kruglyak L. PMID: 25340754; PMCID: PMC4207643.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    52. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics. 2014 Nov; 198(3):1277-90. Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW. PMID: 25189874; PMCID: PMC4224166.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    53. Genetic basis of metabolome variation in yeast. PLoS Genet. 2014 Mar; 10(3):e1004142. Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. PMID: 24603560; PMCID: PMC3945093.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    54. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. PLoS Genet. 2014 Feb; 10(2):e1004156. Andersen EC, Bloom JS, Gerke JP, Kruglyak L. PMID: 24586193; PMCID: PMC3937155.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    55. Genetics of single-cell protein abundance variation in large yeast populations. Nature. 2014 Feb 27; 506(7489):494-7. Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L. PMID: 24402228; PMCID: PMC4285441.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    56. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda). 2013 04 09; 3(4):733-740. Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess DC. PMID: 23550140; PMCID: PMC3618360.
      View in: PubMed   Mentions: 7     Fields:    
    57. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet. 2013; 9(3):e1003329. Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. PMID: 23505383; PMCID: PMC3591295.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    58. Finding the sources of missing heritability in a yeast cross. Nature. 2013 Feb 14; 494(7436):234-7. Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L. PMID: 23376951; PMCID: PMC4001867.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimals
    59. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet. 2012; 8(12):e1003157. Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. PMID: 23284308; PMCID: PMC3527333.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    60. Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol. 2012 Oct 31; 10:85. Ghosh R, Mohammadi A, Kruglyak L, Ryu WS. PMID: 23114012; PMCID: PMC3520762.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    61. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 2012 Dec; 192(4):1533-42. Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC. PMID: 23086219; PMCID: PMC3512158.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    62. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science. 2012 Jul 27; 337(6093):470-3. Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. PMID: 22773140; PMCID: PMC3845625.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    63. Genetic architecture of highly complex chemical resistance traits across four yeast strains. PLoS Genet. 2012; 8(3):e1002570. Ehrenreich IM, Bloom J, Torabi N, Wang X, Jia Y, Kruglyak L. PMID: 22438822; PMCID: PMC3305394.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    64. Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast. PLoS Genet. 2012; 8(3):e1002546. Torabi N, Kruglyak L. PMID: 22396662; PMCID: PMC3291563.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    65. Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science. 2012 Feb 03; 335(6068):574-8. Ghosh R, Andersen EC, Shapiro JA, Gerke JP, Kruglyak L. PMID: 22301316; PMCID: PMC3273849.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    66. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet. 2012 Jan 29; 44(3):285-90. Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix MA, Kruglyak L. PMID: 22286215; PMCID: PMC3365839.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    67. Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS. Mol Syst Biol. 2012; 8:602. Khan Z, Bloom JS, Amini S, Singh M, Perlman DH, Caudy AA, Kruglyak L. PMID: 22893000; PMCID: PMC3435501.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    68. Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome Biol. 2011 Dec 19; 12(12):R122. Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S. PMID: 22182234; PMCID: PMC3334617.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    69. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol. 2011 Sep; 9(9):e1001144. Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. PMID: 21909241; PMCID: PMC3167781.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    70. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genet. 2011 Aug; 7(8):e1002250. Kwan EX, Foss E, Kruglyak L, Bedalov A. PMID: 21901113; PMCID: PMC3161923.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    71. Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. PLoS Genet. 2011 Jul; 7(7):e1002211. Torabi N, Kruglyak L. PMID: 21829385; PMCID: PMC3145625.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    72. A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biol. 2011 Jul; 9(7):e1001115. Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L. PMID: 21814493; PMCID: PMC3144186.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    73. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature. 2011 Apr 21; 472(7343):313-8. Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI. PMID: 21412235; PMCID: PMC3154120.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    74. Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science. 2010 Oct 15; 330(6002):372-6. Rockman MV, Skrovanek SS, Kruglyak L. PMID: 20947766; PMCID: PMC3138179.
      View in: PubMed   Mentions: 144     Fields:    Translation:AnimalsCells
    75. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. 2010 Apr 15; 464(7291):1039-42. Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. PMID: 20393561; PMCID: PMC2862354.
      View in: PubMed   Mentions: 228     Fields:    Translation:AnimalsCells
    76. Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1482-7. Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. PMID: 20080586; PMCID: PMC2824413.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    77. Finding the missing heritability of complex diseases. Nature. 2009 Oct 08; 461(7265):747-53. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. PMID: 19812666; PMCID: PMC2831613.
      View in: PubMed   Mentions: 3912     Fields:    Translation:Humans
    78. Using expression and genotype to predict drug response in yeast. PLoS One. 2009 Sep 04; 4(9):e6907. Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. PMID: 19730698; PMCID: PMC2731853.
      View in: PubMed   Mentions: 11     Fields:    
    79. Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harb Symp Quant Biol. 2009; 74:145-53. Ehrenreich IM, Gerke JP, Kruglyak L. PMID: 19734204; PMCID: PMC2888688.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    80. Protein quantification across hundreds of experimental conditions. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15544-8. Khan Z, Bloom JS, Garcia BA, Singh M, Kruglyak L. PMID: 19717460; PMCID: PMC2732709.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    81. Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics. 2009 Sep; 183(1):365-83. Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE. PMID: 19581448; PMCID: PMC2746160.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    82. Cause and express. Nat Biotechnol. 2009 Jun; 27(6):544-5. Kruglyak L, Storey JD. PMID: 19513058.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    83. Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics. 2009 May 12; 10:221. Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA. PMID: 19435513; PMCID: PMC2686739.
      View in: PubMed   Mentions: 90     Fields:    Translation:Animals
    84. A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays. Bioinformatics. 2009 Jul 01; 25(13):1609-16. Khan Z, Bloom JS, Kruglyak L, Singh M. PMID: 19389736; PMCID: PMC2732316.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    85. Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet. 2009 Mar; 5(3):e1000419. Rockman MV, Kruglyak L. PMID: 19283065; PMCID: PMC2652117.
      View in: PubMed   Mentions: 245     Fields:    Translation:Animals
    86. Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron. 2009 Mar 12; 61(5):692-9. McGrath PT, Rockman MV, Zimmer M, Jang H, Macosko EZ, Kruglyak L, Bargmann CI. PMID: 19285466; PMCID: PMC2772867.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    87. Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature. 2009 Mar 19; 458(7236):342-5. Schacherer J, Shapiro JA, Ruderfer DM, Kruglyak L. PMID: 19212320; PMCID: PMC2782482.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimals
    88. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science. 2009 Jan 16; 323(5912):382-4. Reddy KC, Andersen EC, Kruglyak L, Kim DH. PMID: 19150845; PMCID: PMC2748219.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    89. Comparative developmental expression profiling of two C. elegans isolates. PLoS One. 2008; 3(12):e4055. Capra EJ, Skrovanek SM, Kruglyak L. PMID: 19116648; PMCID: PMC2605249.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    90. Genetics. It's the sequence, stupid! Science. 2008 Oct 17; 322(5900):380-1. Coller HA, Kruglyak L. PMID: 18927376; PMCID: PMC4765165.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    91. Rise of the machines. PLoS Genet. 2008 Aug 01; 4(8):e1000134. Gresham D, Kruglyak L. PMID: 18670625; PMCID: PMC2467494.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    92. Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans. Nature. 2008 Aug 21; 454(7207):1019-22. Palopoli MF, Rockman MV, TinMaung A, Ramsay C, Curwen S, Aduna A, Laurita J, Kruglyak L. PMID: 18633349; PMCID: PMC2597896.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    93. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. PLoS Genet. 2008 Jul 11; 4(7):e1000123. Demogines A, Smith E, Kruglyak L, Alani E. PMID: 18617998; PMCID: PMC2440805.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    94. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet. 2008 Jul; 40(7):854-61. Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. PMID: 18552845; PMCID: PMC2573859.
      View in: PubMed   Mentions: 298     Fields:    Translation:Animals
    95. Breeding designs for recombinant inbred advanced intercross lines. Genetics. 2008 Jun; 179(2):1069-78. Rockman MV, Kruglyak L. PMID: 18505881; PMCID: PMC2429860.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    96. Gene-environment interaction in yeast gene expression. PLoS Biol. 2008 Apr 15; 6(4):e83. Smith EN, Kruglyak L. PMID: 18416601; PMCID: PMC2292755.
      View in: PubMed   Mentions: 226     Fields:    Translation:Animals
    97. The road to genome-wide association studies. Nat Rev Genet. 2008 Apr; 9(4):314-8. Kruglyak L. PMID: 18283274.
      View in: PubMed   Mentions: 87     Fields:    Translation:Humans
    98. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science. 2008 Feb 01; 319(5863):589-94. Seidel HS, Rockman MV, Kruglyak L. PMID: 18187622; PMCID: PMC2421010.
      View in: PubMed   Mentions: 165     Fields:    Translation:Animals
    99. Genetic basis of proteome variation in yeast. Nat Genet. 2007 Nov; 39(11):1369-75. Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. PMID: 17952072.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    100. Evolution. An embarrassment of switches. Science. 2007 Aug 10; 317(5839):758-9. Kruglyak L, Stern DL. PMID: 17690280.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    101. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS One. 2007 Mar 28; 2(3):e322. Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. PMID: 17389913; PMCID: PMC1829191.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    102. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet. 2007 Apr; 39(4):496-502. Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. PMID: 17334364.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    103. Genetics of global gene expression. Nat Rev Genet. 2006 Nov; 7(11):862-72. Rockman MV, Kruglyak L. PMID: 17047685.
      View in: PubMed   Mentions: 325     Fields:    Translation:HumansAnimalsCells
    104. Population genomic analysis of outcrossing and recombination in yeast. Nat Genet. 2006 Sep; 38(9):1077-81. Ruderfer DM, Pratt SC, Seidel HS, Kruglyak L. PMID: 16892060.
      View in: PubMed   Mentions: 111     Fields:    Translation:Animals
    105. Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome. PLoS Genet. 2006 Sep 08; 2(9):e142. Eberle MA, Rieder MJ, Kruglyak L, Nickerson DA. PMID: 16965180; PMCID: PMC1560400.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    106. Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science. 2006 Apr 28; 312(5773):577-9. Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KD. PMID: 16645095.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsPHPublic Health
    107. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet. 2006 Mar; 2(3):e35. Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. PMID: 16552446; PMCID: PMC1401499.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    108. Molecular genetics: DNA analysis of a putative dog clone. Nature. 2006 Mar 09; 440(7081):E1-2. Parker HG, Kruglyak L, Ostrander EA. PMID: 16525421; PMCID: PMC3559127.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    109. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science. 2006 Mar 31; 311(5769):1932-6. Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. PMID: 16527929.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    110. Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol. 2006 Mar; 13(3):319-27. Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. PMID: 16638537.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    111. Power tools for human genetics. Nat Genet. 2005 Dec; 37(12):1299-300. Kruglyak L. PMID: 16314858.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    112. Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet. 2005 Aug; 1(2):e25. Ronald J, Brem RB, Whittle J, Kruglyak L. PMID: 16121257; PMCID: PMC1189075.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    113. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature. 2005 Aug 04; 436(7051):701-3. Brem RB, Storey JD, Whittle J, Kruglyak L. PMID: 16079846; PMCID: PMC1409747.
      View in: PubMed   Mentions: 169     Fields:    Translation:Animals
    114. Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol. 2005 Aug; 3(8):e267. Storey JD, Akey JM, Kruglyak L. PMID: 16035920; PMCID: PMC1180512.
      View in: PubMed   Mentions: 98     Fields:    Translation:Animals
    115. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res. 2005 Feb; 15(2):284-91. Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. PMID: 15687292; PMCID: PMC546530.
      View in: PubMed   Mentions: 61     Fields:    Translation:Animals
    116. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1572-7. Brem RB, Kruglyak L. PMID: 15659551; PMCID: PMC547855.
      View in: PubMed   Mentions: 287     Fields:    Translation:AnimalsCells
    117. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res. 2004 Dec; 14(12):2388-96. Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. PMID: 15545498; PMCID: PMC534662.
      View in: PubMed   Mentions: 151     Fields:    Translation:Animals
    118. No bias in linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):722-3; author reply 723-7. Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N. PMID: 15338460; PMCID: PMC1182063.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    119. Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol. 2004 Oct; 2(10):e286. Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. PMID: 15361935; PMCID: PMC515367.
      View in: PubMed   Mentions: 209     Fields:    Translation:HumansCells
    120. Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'. Bioinformatics. 2005 Jan 15; 21(2):141-3. Carlson CS, Reider MJ, Nickerson DA, Eberle MA, Kruglyak L. PMID: 15333455.
      View in: PubMed   Mentions: 2     Fields:    
    121. Sequence-based linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):647-53. Furman I, Rieder MJ, Da Ponte S, Carrington DP, Nickerson DA, Kruglyak L, Markianos K. PMID: 15329798; PMCID: PMC1182051.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    122. Mapping complex disease loci in whole-genome association studies. Nature. 2004 May 27; 429(6990):446-52. Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. PMID: 15164069.
      View in: PubMed   Mentions: 177     Fields:    Translation:Humans
    123. Genetic structure of the purebred domestic dog. Science. 2004 May 21; 304(5674):1160-4. Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. PMID: 15155949.
      View in: PubMed   Mentions: 220     Fields:    Translation:AnimalsCells
    124. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet. 2004 Apr; 74(4):610-22. Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Kruglyak L, Nickerson DA. PMID: 15015130; PMCID: PMC1181939.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    125. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet. 2004 Jan; 74(1):106-20. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. PMID: 14681826; PMCID: PMC1181897.
      View in: PubMed   Mentions: 721     Fields:    Translation:Humans
    126. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet. 2003 Sep; 35(1):57-64. Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. PMID: 12897782.
      View in: PubMed   Mentions: 323     Fields:    Translation:AnimalsCells
    127. A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. Am J Hum Genet. 2003 Aug; 73(2):271-84. Matise TC, Sachidanandam R, Clark AG, Kruglyak L, Wijsman E, Kakol J, Buyske S, Chui B, Cohen P, de Toma C, Ehm M, Glanowski S, He C, Heil J, Markianos K, McMullen I, Pericak-Vance MA, Silbergleit A, Stein L, Wagner M, Wilson AF, Winick JD, Winn-Deen ES, Yamashiro CT, Cann HM, Lai E, Holden AL. PMID: 12844283; PMCID: PMC1180367.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    128. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet. 2003 Apr; 33(4):518-21. Carlson CS, Eberle MA, Rieder MJ, Smith JD, Kruglyak L, Nickerson DA. PMID: 12652300.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    129. Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population. Science. 2002 Oct 04; 298(5591):213-6. Niaré O, Markianos K, Volz J, Oduol F, Touré A, Bagayoko M, Sangaré D, Traoré SF, Wang R, Blass C, Dolo G, Bouaré M, Kafatos FC, Kruglyak L, Touré YT, Vernick KD. PMID: 12364806.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsPHPublic Health
    130. Patterns of linkage disequilibrium in the human genome. Nat Rev Genet. 2002 Apr; 3(4):299-309. Ardlie KG, Kruglyak L, Seielstad M. PMID: 11967554.
      View in: PubMed   Mentions: 355     Fields:    Translation:HumansAnimals
    131. Genetic dissection of transcriptional regulation in budding yeast. Science. 2002 Apr 26; 296(5568):752-5. Brem RB, Yvert G, Clinton R, Kruglyak L. PMID: 11923494.
      View in: PubMed   Mentions: 663     Fields:    Translation:AnimalsCells
    132. A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. Am J Hum Genet. 2002 Apr; 70(4):1044-8. Eberle MA, Pfützer R, Pogue-Geile KL, Bronner MP, Crispin D, Kimmey MB, Duerr RH, Kruglyak L, Whitcomb DC, Brentnall TA. PMID: 11870593; PMCID: PMC379100.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    133. Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. Am J Hum Genet. 2002 Feb; 70(2):509-16. Lindgren CM, Mahtani MM, Widén E, McCarthy MI, Daly MJ, Kirby A, Reeve MP, Kruglyak L, Parker A, Meyer J, Almgren P, Lehto M, Kanninen T, Tuomi T, Groop LC, Lander ES. PMID: 11791216; PMCID: PMC384923.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    134. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am J Hum Genet. 2001 Sep; 69(3):582-9. Ardlie K, Liu-Cordero SN, Eberle MA, Daly M, Barrett J, Winchester E, Lander ES, Kruglyak L. PMID: 11473344; PMCID: PMC1235487.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    135. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Am J Hum Genet. 2001 Aug; 69(2):381-95. Subrahmanyan L, Eberle MA, Clark AG, Kruglyak L, Nickerson DA. PMID: 11438886; PMCID: PMC1235310.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    136. Efficient multipoint linkage analysis through reduction of inheritance space. Am J Hum Genet. 2001 Apr; 68(4):963-77. Markianos K, Daly MJ, Kruglyak L. PMID: 11254453; PMCID: PMC1275650.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    137. Variation is the spice of life. Nat Genet. 2001 Mar; 27(3):234-6. Kruglyak L, Nickerson DA. PMID: 11242096.
      View in: PubMed   Mentions: 204     Fields:    Translation:Humans
    138. A joint analysis of asthma affection status and IgE levels in multiple data sets collected for asthma. Genet Epidemiol. 2001; 21 Suppl 1:S148-53. Markianos K, Carlson S, Gibbs M, Kruglyak L. PMID: 11793658.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    139. Guilt by association. Nat Genet. 2000 Oct; 26(2):135-7. Altshuler D, Daly M, Kruglyak L. PMID: 11017062.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    140. Unleashing the canine genome. Genome Res. 2000 Sep; 10(9):1271-4. Ostrander EA, Kruglyak L. PMID: 10984444.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    141. Sampling SNPs. Nat Genet. 2000 Sep; 26(1):13-4. Yang Z, Wong GK, Eberle MA, Kibukawa M, Passey DA, Hughes WR, Kruglyak L, Yu J. PMID: 10973237.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    142. Precise gene localization by phenotypic assay of radiation hybrid cells. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7388-92. Rasko JE, Battini JL, Kruglyak L, Cox DR, Miller AD. PMID: 10852967; PMCID: PMC16555.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    143. No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. Am J Med Genet. 2000 Apr 03; 96(2):224-7. Nancarrow DJ, Levinson DF, Taylor JM, Hayward NK, Walters MK, Lennon DP, Nertney DA, Jones HL, Mahtani MM, Kirby A, Kruglyak L, Brown DM, Crowe RR, Andreasen NC, Black DW, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Mowry BJ. PMID: 10893501.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    144. Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. Am J Hum Genet. 2000 Mar; 66(3):1153-7. Pratt SC, Daly MJ, Kruglyak L. PMID: 10712227; PMCID: PMC1288151.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    145. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. Am J Hum Genet. 2000 Jan; 66(1):205-15. Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, McInnis M, Simpson S, McMahon F, Stine OC, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, Folstein S, Daly M, Kruglyak L, Marr T, DePaulo JR, Botstein D. PMID: 10631152; PMCID: PMC1288327.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    146. An analysis of strategies for discovery of single-nucleotide polymorphisms. Genet Epidemiol. 2000; 19 Suppl 1:S29-35. Eberle MA, Kruglyak L. PMID: 11055367.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    147. Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nat Genet. 1999 Jun; 22(2):139-44. Kruglyak L. PMID: 10369254.
      View in: PubMed   Mentions: 319     Fields:    Translation:Humans
    148. Genetic isolates: separate but equal? Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1170-2. Kruglyak L. PMID: 9989995; PMCID: PMC33550.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    149. Genome scan of schizophrenia. Am J Psychiatry. 1998 Jun; 155(6):741-50. Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, Walters MK, Lennon DP, Jones HL, Nertney DA, Daly MJ, Gladis M, Mowry BJ. PMID: 9619145.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    150. Genetic polymorphisms and disease. N Engl J Med. 1998 May 28; 338(22):1626. Altshuler D, Kruglyak L, Lander E. PMID: 9606122.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    151. Siblings of centenarians live longer. Lancet. 1998 May 23; 351(9115):1560. Perls TT, Bubrick E, Wager CG, Vijg J, Kruglyak L. PMID: 10326548.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    152. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 1998 May 15; 280(5366):1077-82. Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES. PMID: 9582121.
      View in: PubMed   Mentions: 463     Fields:    Translation:HumansCells
    153. Linkage thresholds for two-stage genome scans. Am J Hum Genet. 1998 Apr; 62(4):994-7. Kruglyak L, Daly MJ. PMID: 9529350; PMCID: PMC1377032.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    154. Who needs genetic markers? Nat Genet. 1998 Mar; 18(3):200-2. Kruglyak L, McAllister L. PMID: 9500532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    155. Faster multipoint linkage analysis using Fourier transforms. J Comput Biol. 1998; 5(1):1-7. Kruglyak L, Lander ES. PMID: 9541867.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    156. Sib-pair collection strategies for complex diseases. Genet Epidemiol. 1998; 15(4):317-40. McCarthy MI, Kruglyak L, Lander ES. PMID: 9671984.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    157. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet. 1997 Nov; 6(12):2069-76. Laitinen T, Kauppi P, Ignatius J, Ruotsalainen T, Daly MJ, Kääriäinen H, Kruglyak L, Laitinen H, de la Chapelle A, Lander ES, Laitinen LA, Kere J. PMID: 9328470.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    158. What is significant in whole-genome linkage disequilibrium studies? Am J Hum Genet. 1997 Oct; 61(4):810-2. Kruglyak L. PMID: 9382090; PMCID: PMC1715992.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    159. The use of a genetic map of biallelic markers in linkage studies. Nat Genet. 1997 Sep; 17(1):21-4. Kruglyak L. PMID: 9288093.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    160. Nonparametric linkage tests are model free. Am J Hum Genet. 1997 Jul; 61(1):254-5. Kruglyak L. PMID: 9246012; PMCID: PMC1715868.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    161. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May; 18(5):711-22. Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES. PMID: 9182797.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    162. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):587-92. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W. PMID: 9012828; PMCID: PMC19557.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansCells
    163. Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? Genet Epidemiol. 1997; 14(6):599-604. Daly M, Kirby A, Kruglyak L. PMID: 9433549.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    164. Building human genome maps with radiation hybrids. J Comput Biol. 1997; 4(4):487-504. Slonim D, Kruglyak L, Stein L, Lander E. PMID: 9385541.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    165. Thresholds and sample sizes. Nat Genet. 1996 Oct; 14(2):132-3. Kruglyak L. PMID: 8841180.
      View in: PubMed   Mentions: 5     Fields:    
    166. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet. 1996 Sep; 14(1):90-4. Mahtani MM, Widén E, Lehto M, Thomas J, McCarthy M, Brayer J, Bryant B, Chan G, Daly M, Forsblom C, Kanninen T, Kirby A, Kruglyak L, Munnelly K, Parkkonen M, Reeve-Daly MP, Weaver A, Brettin T, Duyk G, Lander ES, Groop LC. PMID: 8782826.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    167. A locus for Fanconi anemia on 16q determined by homozygosity mapping. Am J Hum Genet. 1996 Aug; 59(2):377-84. Gschwend M, Levran O, Kruglyak L, Ranade K, Verlander PC, Shen S, Faure S, Weissenbach J, Altay C, Lander ES, Auerbach AD, Botstein D. PMID: 8755924; PMCID: PMC1914713.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    168. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet. 1996 Jun; 58(6):1347-63. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. PMID: 8651312; PMCID: PMC1915045.
      View in: PubMed   Mentions: 828     Fields:    Translation:Humans
    169. Limits on fine mapping of complex traits. Am J Hum Genet. 1996 May; 58(5):1092-3. Kruglyak L, Lander ES. PMID: 8651271; PMCID: PMC1914627.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    170. Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246. Am J Hum Genet. 1996 Mar; 58(3):523-34. Levy EN, Shen Y, Kupelian A, Kruglyak L, Aksentijevich I, Pras E, Balow JE, Linzer B, Chen X, Shelton DA, Gumucio D, Pras M, Shohat M, Rotter JI, Fischel-Ghodsian N, Richards RI, Kastner DL. PMID: 8644712; PMCID: PMC1914560.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    171. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996 Feb 22; 379(6567):736-9. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES. PMID: 8602221.
      View in: PubMed   Mentions: 177     Fields:    Translation:AnimalsCells
    172. An STS-based map of the human genome. Science. 1995 Dec 22; 270(5244):1945-54. Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Fauré S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES. PMID: 8533086.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    173. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995 Nov; 11(3):241-7. Lander E, Kruglyak L. PMID: 7581446.
      View in: PubMed   Mentions: 1409     Fields:    
    174. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat Genet. 1995 Nov; 11(3):248-56. Hu S, Pattatucci AM, Patterson C, Li L, Fulker DW, Cherny SS, Kruglyak L, Hamer DH. PMID: 7581447.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    175. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet. 1995 Aug; 57(2):439-54. Kruglyak L, Lander ES. PMID: 7668271; PMCID: PMC1801561.
      View in: PubMed   Mentions: 195     Fields:    Translation:Humans
    176. High-resolution genetic mapping of complex traits. Am J Hum Genet. 1995 May; 56(5):1212-23. Kruglyak L, Lander ES. PMID: 7726179; PMCID: PMC1801437.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    177. A nonparametric approach for mapping quantitative trait loci. Genetics. 1995 Mar; 139(3):1421-8. Kruglyak L, Lander ES. PMID: 7768449; PMCID: PMC1206467.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    178. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet. 1995 Feb; 56(2):519-27. Kruglyak L, Daly MJ, Lander ES. PMID: 7847388; PMCID: PMC1801139.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    179. Sexual orientation. Nature. 1993 Oct 21; 365(6448):702. Kruglyak L. PMID: 8413649.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    Leonid's Networks
    Concepts (544)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (25)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCLA Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version UCSF-v3.1.0-12-gbedcc43d on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California