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Kruglyak, Leonid

Title(s)Professor, Human Genetics
Phone3108255486
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    Other Positions
    Title(s)Professor, Biological Chemistry


    Collapse Research 
    Collapse Research Activities and Funding
    High-throughput identification of causal variants underlying quantitative traits in yeast
    NIH/NIGMS R01GM102308Sep 1, 2012 - May 31, 2016
    Role: Principal Investigator
    Genetic dissection of complex traits in C. elegans
    NIH/NHGRI R01HG004321Aug 16, 2007 - May 31, 2015
    Role: Principal Investigator
    UW-FHCRC Variation Discovery Resource
    NIH/NHLBI U01HL066642Sep 30, 2000 - Jul 31, 2010
    Role: Co-Principal Investigator
    Quantitative Methods for Linkage and Associated Studies
    NIH/NIMH R37MH059520Dec 1, 1998 - Nov 30, 2012
    Role: Principal Investigator
    QUANTITATIVE METHODS FOR LINKAGE AND ASSOCIATION STUDIES
    NIH/NIMH R01MH059520Dec 1, 1998 - Nov 30, 2001
    Role: Principal Investigator
    MATHEMATICAL AND COMPUTATIONAL ISSUES IN GENOME ANALYSIS
    NIH/NHGRI K01HG000017Dec 1, 1994 - Nov 30, 1999
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Karavani E, Zuk O, Zeevi D, Barzilai N, Stefanis NC, Hatzimanolis A, Smyrnis N, Avramopoulos D, Kruglyak L, Atzmon G, Lam M, Lencz T, Carmi S. Screening Human Embryos for Polygenic Traits Has Limited Utility. Cell. 2019 Nov 27; 179(6):1424-1435.e8. PMID: 31761530.
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    2. Bloom JS, Boocock J, Treusch S, Sadhu MJ, Day L, Oates-Barker H, Kruglyak L. Rare variants contribute disproportionately to quantitative trait variation in yeast. Elife. 2019 10 24; 8. PMID: 31647408.
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    3. Zeevi D, Bloom JS, Sadhu MJ, Ben Yehuda A, Zangen D, Levy-Lahad E, Kruglyak L. Analysis of the genetic basis of height in large Jewish nuclear families. PLoS Genet. 2019 07; 15(7):e1008082. PMID: 31283753.
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    4. Burga A, Ben-David E, Lemus Vergara T, Boocock J, Kruglyak L. Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk. Nat Commun. 2019 06 18; 10(1):2680. PMID: 31213597.
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    5. Gou L, Bloom JS, Kruglyak L. The Genetic Basis of Mutation Rate Variation in Yeast. Genetics. 2019 02; 211(2):731-740. PMID: 30504363.
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    6. Sadhu MJ, Kruglyak L. How Low Can You Go? CRISPR J. 2018 10; 1:312-313. PMID: 31021269.
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    7. Albert FW, Bloom JS, Siegel J, Day L, Kruglyak L. Genetics of trans-regulatory variation in gene expression. Elife. 2018 07 17; 7. PMID: 30014850.
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    8. Sadhu MJ, Bloom JS, Day L, Siegel JJ, Kosuri S, Kruglyak L. Highly parallel genome variant engineering with CRISPR-Cas9. Nat Genet. 2018 04; 50(4):510-514. PMID: 29632376.
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    9. Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J. The genetic basis of natural variation in a phoretic behavior. Nat Commun. 2017 08 17; 8(1):273. PMID: 28819099.
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    10. Jerison ER, Kryazhimskiy S, Mitchell JK, Bloom JS, Kruglyak L, Desai MM. Genetic variation in adaptability and pleiotropy in budding yeast. Elife. 2017 08 17; 6. PMID: 28826486.
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    11. Burga A, Wang W, Ben-David E, Wolf PC, Ramey AM, Verdugo C, Lyons K, Parker PG, Kruglyak L. A genetic signature of the evolution of loss of flight in the Galapagos cormorant. Science. 2017 Jun 02; 356(6341). PMID: 28572335.
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    12. Ben-David E, Burga A, Kruglyak L. A maternal-effect selfish genetic element in Caenorhabditis elegans. Science. 2017 06 09; 356(6342):1051-1055. PMID: 28495877.
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    13. Forsberg SK, Bloom JS, Sadhu MJ, Kruglyak L, Carlborg Ö. Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast. Nat Genet. 2017 Apr; 49(4):497-503. PMID: 28250458.
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    14. Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix MA, Lee J, Andersen EC. The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Genetics. 2016 09; 204(1):371-83. PMID: 27449056.
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    15. Kruglyak L. Complex Traits and Simple Systems: An Interview with Leonid Kruglyak. Genetics. 2016 Jul; 203(3):1023-5. PMID: 27384025.
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    16. Sadhu MJ, Bloom JS, Day L, Kruglyak L. CRISPR-directed mitotic recombination enables genetic mapping without crosses. Science. 2016 May 27; 352(6289):1113-6. PMID: 27230379.
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    17. Kruglyak L. 2015 Curt Stern Award. Am J Hum Genet. 2016 Mar 03; 98(3):428-430. PMID: 26942280.
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    18. Bloom JS, Kotenko I, Sadhu MJ, Treusch S, Albert FW, Kruglyak L. Genetic interactions contribute less than additive effects to quantitative trait variation in yeast. Nat Commun. 2015 Nov 05; 6:8712. PMID: 26537231.
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    19. Ghosh R, Bloom JS, Mohammadi A, Schumer ME, Andolfatto P, Ryu W, Kruglyak L. Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans. Genetics. 2015 Aug; 200(4):1327-39. PMID: 26092720.
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    20. Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJ, Brenchley R, Van't Hof A, Bevers RP, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, Waterston RH. Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Genetics. 2015 Jul; 200(3):975-89. PMID: 25995208.
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    21. Thomas CG, Wang W, Jovelin R, Ghosh R, Lomasko T, Trinh Q, Kruglyak L, Stein LD, Cutter AD. Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis. Genome Res. 2015 May; 25(5):667-78. PMID: 25783854.
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    22. Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, Kruglyak L. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. G3 (Bethesda). 2015 Mar 13; 5(5):911-20. PMID: 25770127.
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    23. Albert FW, Kruglyak L. The role of regulatory variation in complex traits and disease. Nat Rev Genet. 2015 Apr; 16(4):197-212. PMID: 25707927.
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    24. Balla KM, Andersen EC, Kruglyak L, Troemel ER. A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite. PLoS Pathog. 2015 Feb; 11(2):e1004583. PMID: 25680197.
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    25. Treusch S, Albert FW, Bloom JS, Kotenko IE, Kruglyak L. Genetic mapping of MAPK-mediated complex traits Across S. cerevisiae. PLoS Genet. 2015 Jan; 11(1):e1004913. PMID: 25569670.
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    26. Wang X, Kruglyak L. Genetic basis of haloperidol resistance in Saccharomyces cerevisiae is complex and dose dependent. PLoS Genet. 2014 Dec; 10(12):e1004894. PMID: 25521586.
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    27. Albert FW, Muzzey D, Weissman JS, Kruglyak L. Genetic influences on translation in yeast. PLoS Genet. 2014 Oct; 10(10):e1004692. PMID: 25340754.
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    28. Heyne HO, Lautenschläger S, Nelson R, Besnier F, Rotival M, Cagan A, Kozhemyakina R, Plyusnina IZ, Trut L, Carlborg Ö, Petretto E, Kruglyak L, Pääbo S, Schöneberg T, Albert FW. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics. 2014 Nov; 198(3):1277-90. PMID: 25189874.
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    29. Breunig JS, Hackett SR, Rabinowitz JD, Kruglyak L. Genetic basis of metabolome variation in yeast. PLoS Genet. 2014 Mar; 10(3):e1004142. PMID: 24603560.
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    30. Andersen EC, Bloom JS, Gerke JP, Kruglyak L. A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology. PLoS Genet. 2014 Feb; 10(2):e1004156. PMID: 24586193.
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    31. Albert FW, Treusch S, Shockley AH, Bloom JS, Kruglyak L. Genetics of single-cell protein abundance variation in large yeast populations. Nature. 2014 Feb 27; 506(7489):494-7. PMID: 24402228.
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    32. Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess DC. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda). 2013 04 09; 3(4):733-740. PMID: 23550140.
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    33. Kwan EX, Foss EJ, Tsuchiyama S, Alvino GM, Kruglyak L, Kaeberlein M, Raghuraman MK, Brewer BJ, Kennedy BK, Bedalov A. A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. PLoS Genet. 2013; 9(3):e1003329. PMID: 23505383.
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    34. Bloom JS, Ehrenreich IM, Loo WT, Lite TL, Kruglyak L. Finding the sources of missing heritability in a yeast cross. Nature. 2013 Feb 14; 494(7436):234-7. PMID: 23376951.
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    35. Bendesky A, Pitts J, Rockman MV, Chen WC, Tan MW, Kruglyak L, Bargmann CI. Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans. PLoS Genet. 2012; 8(12):e1003157. PMID: 23284308.
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    36. Ghosh R, Mohammadi A, Kruglyak L, Ryu WS. Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans. BMC Biol. 2012 Oct 31; 10:85. PMID: 23114012.
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    37. Gaertner BE, Parmenter MD, Rockman MV, Kruglyak L, Phillips PC. More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Genetics. 2012 Dec; 192(4):1533-42. PMID: 23086219.
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    38. Reaves ML, Sinha S, Rabinowitz JD, Kruglyak L, Redfield RJ. Absence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells. Science. 2012 Jul 27; 337(6093):470-3. PMID: 22773140.
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    39. Ehrenreich IM, Bloom J, Torabi N, Wang X, Jia Y, Kruglyak L. Genetic architecture of highly complex chemical resistance traits across four yeast strains. PLoS Genet. 2012; 8(3):e1002570. PMID: 22438822.
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    40. Torabi N, Kruglyak L. Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast. PLoS Genet. 2012; 8(3):e1002546. PMID: 22396662.
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    41. Ghosh R, Andersen EC, Shapiro JA, Gerke JP, Kruglyak L. Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans. Science. 2012 Feb 03; 335(6068):574-8. PMID: 22301316.
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    42. Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix MA, Kruglyak L. Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet. 2012 Jan 29; 44(3):285-90. PMID: 22286215.
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    43. Khan Z, Bloom JS, Amini S, Singh M, Perlman DH, Caudy AA, Kruglyak L. Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS. Mol Syst Biol. 2012; 8:602. PMID: 22893000.
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    44. Khan Z, Amini S, Bloom JS, Ruse C, Caudy AA, Kruglyak L, Singh M, Perlman DH, Tavazoie S. Accurate proteome-wide protein quantification from high-resolution 15N mass spectra. Genome Biol. 2011 Dec 19; 12(12):R122. PMID: 22182234.
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    45. Foss EJ, Radulovic D, Shaffer SA, Goodlett DR, Kruglyak L, Bedalov A. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol. 2011 Sep; 9(9):e1001144. PMID: 21909241.
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    46. Kwan EX, Foss E, Kruglyak L, Bedalov A. Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. PLoS Genet. 2011 Aug; 7(8):e1002250. PMID: 21901113.
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    47. Torabi N, Kruglyak L. Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. PLoS Genet. 2011 Jul; 7(7):e1002211. PMID: 21829385.
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    48. Seidel HS, Ailion M, Li J, van Oudenaarden A, Rockman MV, Kruglyak L. A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. PLoS Biol. 2011 Jul; 9(7):e1001115. PMID: 21814493.
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    49. Bendesky A, Tsunozaki M, Rockman MV, Kruglyak L, Bargmann CI. Catecholamine receptor polymorphisms affect decision-making in C. elegans. Nature. 2011 Apr 21; 472(7343):313-8. PMID: 21412235.
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    50. Rockman MV, Skrovanek SS, Kruglyak L. Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science. 2010 Oct 15; 330(6002):372-6. PMID: 20947766.
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    51. Ehrenreich IM, Torabi N, Jia Y, Kent J, Martis S, Shapiro JA, Gresham D, Caudy AA, Kruglyak L. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature. 2010 Apr 15; 464(7291):1039-42. PMID: 20393561.
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    52. Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1482-7. PMID: 20080586.
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    53. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009 Oct 08; 461(7265):747-53. PMID: 19812666.
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    54. Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast. PLoS One. 2009 Sep 04; 4(9):e6907. PMID: 19730698.
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    55. Ehrenreich IM, Gerke JP, Kruglyak L. Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. Cold Spring Harb Symp Quant Biol. 2009; 74:145-53. PMID: 19734204.
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    56. Khan Z, Bloom JS, Garcia BA, Singh M, Kruglyak L. Protein quantification across hundreds of experimental conditions. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15544-8. PMID: 19717460.
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    57. Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE. Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics. 2009 Sep; 183(1):365-83. PMID: 19581448.
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    58. Kruglyak L, Storey JD. Cause and express. Nat Biotechnol. 2009 Jun; 27(6):544-5. PMID: 19513058.
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    59. Bloom JS, Khan Z, Kruglyak L, Singh M, Caudy AA. Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics. 2009 May 12; 10:221. PMID: 19435513.
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    60. Khan Z, Bloom JS, Kruglyak L, Singh M. A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays. Bioinformatics. 2009 Jul 01; 25(13):1609-16. PMID: 19389736.
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    61. Rockman MV, Kruglyak L. Recombinational landscape and population genomics of Caenorhabditis elegans. PLoS Genet. 2009 Mar; 5(3):e1000419. PMID: 19283065.
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    62. McGrath PT, Rockman MV, Zimmer M, Jang H, Macosko EZ, Kruglyak L, Bargmann CI. Quantitative mapping of a digenic behavioral trait implicates globin variation in C. elegans sensory behaviors. Neuron. 2009 Mar 12; 61(5):692-9. PMID: 19285466.
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    63. Schacherer J, Shapiro JA, Ruderfer DM, Kruglyak L. Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae. Nature. 2009 Mar 19; 458(7236):342-5. PMID: 19212320.
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    64. Reddy KC, Andersen EC, Kruglyak L, Kim DH. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Science. 2009 Jan 16; 323(5912):382-4. PMID: 19150845.
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    65. Capra EJ, Skrovanek SM, Kruglyak L. Comparative developmental expression profiling of two C. elegans isolates. PLoS One. 2008; 3(12):e4055. PMID: 19116648.
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    66. Coller HA, Kruglyak L. Genetics. It's the sequence, stupid! Science. 2008 Oct 17; 322(5900):380-1. PMID: 18927376.
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    67. Gresham D, Kruglyak L. Rise of the machines. PLoS Genet. 2008 Aug 01; 4(8):e1000134. PMID: 18670625.
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    68. Palopoli MF, Rockman MV, TinMaung A, Ramsay C, Curwen S, Aduna A, Laurita J, Kruglyak L. Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans. Nature. 2008 Aug 21; 454(7207):1019-22. PMID: 18633349.
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    69. Demogines A, Smith E, Kruglyak L, Alani E. Identification and dissection of a complex DNA repair sensitivity phenotype in Baker's yeast. PLoS Genet. 2008 Jul 11; 4(7):e1000123. PMID: 18617998.
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    70. Zhu J, Zhang B, Smith EN, Drees B, Brem RB, Kruglyak L, Bumgarner RE, Schadt EE. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nat Genet. 2008 Jul; 40(7):854-61. PMID: 18552845.
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    71. Rockman MV, Kruglyak L. Breeding designs for recombinant inbred advanced intercross lines. Genetics. 2008 Jun; 179(2):1069-78. PMID: 18505881.
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    72. Smith EN, Kruglyak L. Gene-environment interaction in yeast gene expression. PLoS Biol. 2008 Apr 15; 6(4):e83. PMID: 18416601.
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    73. Kruglyak L. The road to genome-wide association studies. Nat Rev Genet. 2008 Apr; 9(4):314-8. PMID: 18283274.
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    74. Seidel HS, Rockman MV, Kruglyak L. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science. 2008 Feb 01; 319(5863):589-94. PMID: 18187622.
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    75. Foss EJ, Radulovic D, Shaffer SA, Ruderfer DM, Bedalov A, Goodlett DR, Kruglyak L. Genetic basis of proteome variation in yeast. Nat Genet. 2007 Nov; 39(11):1369-75. PMID: 17952072.
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    76. Kruglyak L, Stern DL. Evolution. An embarrassment of switches. Science. 2007 Aug 10; 317(5839):758-9. PMID: 17690280.
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    77. Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. PLoS One. 2007 Mar 28; 2(3):e322. PMID: 17389913.
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    78. Perlstein EO, Ruderfer DM, Roberts DC, Schreiber SL, Kruglyak L. Genetic basis of individual differences in the response to small-molecule drugs in yeast. Nat Genet. 2007 Apr; 39(4):496-502. PMID: 17334364.
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    79. Rockman MV, Kruglyak L. Genetics of global gene expression. Nat Rev Genet. 2006 Nov; 7(11):862-72. PMID: 17047685.
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    80. Ruderfer DM, Pratt SC, Seidel HS, Kruglyak L. Population genomic analysis of outcrossing and recombination in yeast. Nat Genet. 2006 Sep; 38(9):1077-81. PMID: 16892060.
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    81. Eberle MA, Rieder MJ, Kruglyak L, Nickerson DA. Allele frequency matching between SNPs reveals an excess of linkage disequilibrium in genic regions of the human genome. PLoS Genet. 2006 Sep 08; 2(9):e142. PMID: 16965180.
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    82. Riehle MM, Markianos K, Niaré O, Xu J, Li J, Touré AM, Podiougou B, Oduol F, Diawara S, Diallo M, Coulibaly B, Ouatara A, Kruglyak L, Traoré SF, Vernick KD. Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science. 2006 Apr 28; 312(5773):577-9. PMID: 16645095.
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    83. Gatbonton T, Imbesi M, Nelson M, Akey JM, Ruderfer DM, Kruglyak L, Simon JA, Bedalov A. Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet. 2006 Mar; 2(3):e35. PMID: 16552446.
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    84. Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science. 2006 Mar 31; 311(5769):1932-6. PMID: 16527929.
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    85. Parker HG, Kruglyak L, Ostrander EA. Molecular genetics: DNA analysis of a putative dog clone. Nature. 2006 Mar 09; 440(7081):E1-2. PMID: 16525421.
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    86. Perlstein EO, Ruderfer DM, Ramachandran G, Haggarty SJ, Kruglyak L, Schreiber SL. Revealing complex traits with small molecules and naturally recombinant yeast strains. Chem Biol. 2006 Mar; 13(3):319-27. PMID: 16638537.
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    87. Kruglyak L. Power tools for human genetics. Nat Genet. 2005 Dec; 37(12):1299-300. PMID: 16314858.
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    88. Ronald J, Brem RB, Whittle J, Kruglyak L. Local regulatory variation in Saccharomyces cerevisiae. PLoS Genet. 2005 Aug; 1(2):e25. PMID: 16121257.
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    89. Brem RB, Storey JD, Whittle J, Kruglyak L. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature. 2005 Aug 04; 436(7051):701-3. PMID: 16079846.
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    90. Storey JD, Akey JM, Kruglyak L. Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol. 2005 Aug; 3(8):e267. PMID: 16035920.
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    91. Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res. 2005 Feb; 15(2):284-91. PMID: 15687292.
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    92. Brem RB, Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1572-7. PMID: 15659551.
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    93. Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. Extensive and breed-specific linkage disequilibrium in Canis familiaris. Genome Res. 2004 Dec; 14(12):2388-96. PMID: 15545498.
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    94. Abecasis G, Cox N, Daly MJ, Kruglyak L, Laird N, Markianos K, Patterson N. No bias in linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):722-3; author reply 723-7. PMID: 15338460.
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    95. Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L. Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol. 2004 Oct; 2(10):e286. PMID: 15361935.
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    96. Carlson CS, Reider MJ, Nickerson DA, Eberle MA, Kruglyak L. Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'. Bioinformatics. 2005 Jan 15; 21(2):141-3. PMID: 15333455.
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    97. Furman I, Rieder MJ, Da Ponte S, Carrington DP, Nickerson DA, Kruglyak L, Markianos K. Sequence-based linkage analysis. Am J Hum Genet. 2004 Oct; 75(4):647-53. PMID: 15329798.
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    98. Carlson CS, Eberle MA, Kruglyak L, Nickerson DA. Mapping complex disease loci in whole-genome association studies. Nature. 2004 May 27; 429(6990):446-52. PMID: 15164069.
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    99. Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog. Science. 2004 May 21; 304(5674):1160-4. PMID: 15155949.
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    100. Crawford DC, Carlson CS, Rieder MJ, Carrington DP, Yi Q, Smith JD, Eberle MA, Kruglyak L, Nickerson DA. Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet. 2004 Apr; 74(4):610-22. PMID: 15015130.
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    101. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet. 2004 Jan; 74(1):106-20. PMID: 14681826.
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