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Aldons J Lusis

Title(s)Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 32-144
Los Angeles CA 90024
Phone310-825-1359
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    Other Positions
    Title(s)Professor, Human Genetics

    Title(s)Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    Establishing mechanistic links between the gut microbiome and atherosclerosis
    NIH/NHLBI R01HL148577Apr 1, 2020 - Mar 31, 2024
    Role: Co-Principal Investigator
    Systems genetics approach to inflammatory mechanisms in atherosclerosis
    NIH/NHLBI R01HL147883Jul 12, 2019 - May 31, 2023
    Role: Principal Investigator
    Systems genetics dissection of non-alcoholic steatohepatitis
    NIH/NIDDK R01DK117850Jul 1, 2019 - Jun 30, 2023
    Role: Principal Investigator
    Gut microbiota and metabolite interactions in atherosclerosis
    NIH/NHLBI R01HL144651Jan 15, 2019 - Oct 31, 2022
    Role: Principal Investigator
    Pharmacogenomics of Statin Therapy
    NIH/NIGMS P50GM115318Sep 7, 2015 - Aug 31, 2020
    Role: Co-Principal Investigator
    Systems Genetics Approach to Atherosclerosis
    NIH/NHLBI R01HL126753Mar 9, 2015 - Jan 31, 2019
    Role: Principal Investigator
    A Systems Approach to Dissect Genetic Basis of Heart Failure
    NIH/NHLBI R01HL123295Apr 1, 2014 - Mar 31, 2018
    Role: Co-Principal Investigator
    Systems Approach to Unraveling the Genetic Basis of Heart Failure
    NIH/NHLBI R01HL114437Sep 4, 2013 - May 31, 2017
    Role: Co-Principal Investigator
    Systems Genetics of Type 1 Diabetes Complications
    NIH/NIDDK DP3DK094311Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator
    A Systems Approach to Uncover Novel Genes and Networks in Heart Failure
    NIH/NHLBI R21HL110667Aug 15, 2011 - May 31, 2013
    Role: Principal Investigator
    Dissection of HDL function using mouse models
    NIH/NHLBI R01HL094322Jul 15, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Integrative genetic approaches to Atherosclerosis
    NIH/NHLBI R01HL095154Jul 15, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    NIH/NIDDK R01DK071673Aug 15, 2005 - Jun 30, 2010
    Role: Principal Investigator
    Molecular Genetic Approaches in Atherosclerosis Research
    NIH/NHLBI P01HL028481Apr 1, 1997 - Mar 31, 2000
    Role: Principal Investigator
    LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    NIH/NHLBI R37HL042488Jul 1, 1989 - May 31, 2000
    Role: Principal Investigator
    LIPOPROTEIN METABOLISM GENETIC CONTROL--MOUSE MODEL
    NIH/NHLBI R01HL042488Jul 1, 1989 - May 30, 1999
    Role: Principal Investigator
    CONTROL OF GRANULOPOIESIS: MOLECULAR GENETIC APPROACH
    NIH/NIADDK R01AM027008Jan 1, 1981 - Dec 31, 1988
    Role: Principal Investigator
    CONTROL OF GRANULOPOIESIS: MOLECULAR GENETIC APPROACH
    NIH/NIDDK R01DK027008Jan 1, 1981 - Dec 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice. Sci Rep. 2020 Oct 08; 10(1):16848. Charles-Schoeman C, Wang J, Shahbazian A, Lee YY, Wang X, Grijalva V, Brahn E, Shih DM, Devarajan A, Montano C, Lusis AJ, Reddy ST. PMID: 33033318.
      View in: PubMed   Mentions:    Fields:    
    2. Publisher Correction: RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice. Nat Metab. 2020 Oct; 2(10):1181. Karunakaran D, Turner AW, Duchez AC, Soubeyrand S, Rasheed A, Smyth D, Cook DP, Nikpay M, Kandiah JW, Pan C, Geoffrion M, Lee R, Boytard L, Wyatt H, Nguyen MA, Lau P, Laakso M, Ramkhelawon B, Alvarez M, Pietiläinen KH, Pajukanta P, Vanderhyden BC, Liu P, Berger SB, Gough PJ, Bertin J, Harper ME, Lusis AJ, McPherson R, Rayner KJ. PMID: 33033401.
      View in: PubMed   Mentions:
    3. RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice. Nat Metab. 2020 Sep 28. Karunakaran D, Turner AW, Duchez AC, Soubeyrand S, Rasheed A, Smyth D, Cook DP, Nikpay M, Kandiah JW, Pan C, Geoffrion M, Lee R, Boytard L, Wyatt H, Nguyen MA, Lau P, Laakso M, Ramkhelawon B, Alvarez M, Pietiläinen KH, Pajukanta P, Vanderhyden BC, Liu P, Berger SB, Gough PJ, Bertin J, Harper ME, Lusis AJ, McPherson R, Rayner KJ. PMID: 32989316.
      View in: PubMed   Mentions:
    4. Liver Pyruvate Kinase Promotes NAFLD/NASH in both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 2020 Sep 14. Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, Canizales-Quinteros S, Divakaruni AS, Huertas-Vazquez A, Lusis AJ. PMID: 32942044.
      View in: PubMed   Mentions:    Fields:    
    5. Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice. J Nutr. 2020 Aug 28. Ahn IS, Lang JM, Olson CA, Diamante G, Zhang G, Ying Z, Byun HR, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis AJ, Hsiao EY, Yang X. PMID: 32856048.
      View in: PubMed   Mentions:    Fields:    
    6. The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice. Cell Mol Gastroenterol Hepatol. 2020 Aug 28. Tuominen I, Fuqua BK, Pan C, Renaud N, Wroblewski K, Civelek M, Clerkin K, Asaryan A, Haroutunian SG, Loureiro J, Borawski J, Roma G, Knehr J, Carbone W, French S, Parks BW, Hui ST, Mehrabian M, Magyar C, Cantor RM, Ukomadu C, Lusis AJ, Beaven SW. PMID: 32866618.
      View in: PubMed   Mentions:    Fields:    
    7. Estrogen receptor a controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 Aug 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275.
      View in: PubMed   Mentions:    Fields:    
    8. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020 Aug 06; 182(3):545-562.e23. Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. PMID: 32621799.
      View in: PubMed   Mentions: 1     Fields:    
    9. Systems Genetics for Mechanistic Discovery in Heart Diseases. Circ Res. 2020 Jun 05; 126(12):1795-1815. Rau CD, Lusis AJ, Wang Y. PMID: 32496909.
      View in: PubMed   Mentions:    Fields:    
    10. Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling. J Am Heart Assoc. 2020 May 18; 9(10):e014257. Korshunov VA, Smolock EM, Wines-Samuelson ME, Faiyaz A, Mickelsen DM, Quinn B, Pan C, Dugbartey GJ, Yan C, Doyley MM, Lusis AJ, Berk BC. PMID: 32394795.
      View in: PubMed   Mentions:    Fields:    
    11. Rosuvastatin Prevents the Exacerbation of Atherosclerosis in Ligature-Induced Periodontal Disease Mouse Model. Sci Rep. 2020 Apr 14; 10(1):6383. Suh JS, Lee SH, Fouladian Z, Lee JY, Kim T, Kang MK, Lusis AJ, Boström KI, Kim RH, Park NH. PMID: 32286430.
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    12. Tribute to Dr. Steve Schwartz. J Mol Cell Cardiol. 2020 Apr 11. Lusis AJ, Liu D, Wang Y. PMID: 32289322.
      View in: PubMed   Mentions:    Fields:    
    13. FAM13A affects body fat distribution and adipocyte function. Nat Commun. 2020 03 19; 11(1):1465. Fathzadeh M, Li J, Rao A, Cook N, Chennamsetty I, Seldin M, Zhou X, Sangwung P, Gloudemans MJ, Keller M, Attie A, Yang J, Wabitsch M, Carcamo-Orive I, Tada Y, Lusis AJ, Shin MK, Molony CM, McLaughlin T, Reaven G, Montgomery SB, Reilly D, Quertermous T, Ingelsson E, Knowles JW. PMID: 32193374.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice. Nat Commun. 2020 02 20; 11(1):984. Zhang Z, Feng AC, Salisbury D, Liu X, Wu X, Kim J, Lapina I, Wang D, Lee B, Fraga J, Pan C, Williams KJ, Lusis AJ, Scumpia P, Sallam T. PMID: 32080181.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    15. A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. PLoS Genet. 2019 12; 15(12):e1008528. Maazi H, Hartiala JA, Suzuki Y, Crow AL, Shafiei Jahani P, Lam J, Patel N, Rigas D, Han Y, Huang P, Eskin E, Lusis AJ, Gilliland FD, Akbari O, Allayee H. PMID: 31869344.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    16. DNA Methylation Changes More Slowly Than Physiological States in Response to Weight Loss in Genetically Diverse Mouse Strains. Front Endocrinol (Lausanne). 2019; 10:882. Edillor CR, Parks BW, Mehrabian M, Lusis AJ, Pellegrini M. PMID: 31920990.
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    17. Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution. Hum Mol Genet. 2019 12 15; 28(24):4161-4172. Wu Y, Broadaway KA, Raulerson CK, Scott LJ, Pan C, Ko A, He A, Tilford C, Fuchsberger C, Locke AE, Stringham HM, Jackson AU, Narisu N, Kuusisto J, Pajukanta P, Collins FS, Boehnke M, Laakso M, Lusis AJ, Civelek M, Mohlke KL. PMID: 31691812.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Y-Chromosome Genetic Variation Associated With Atherosclerosis and Inflammation. Arterioscler Thromb Vasc Biol. 2019 11; 39(11):2201-2202. Lusis AJ. PMID: 31644351.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Systems genetics applications in metabolism research. Nat Metab. 2019 Nov; 1(11):1038-1050. Seldin M, Yang X, Lusis AJ. PMID: 32259026.
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    20. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. Elife. 2019 10 17; 8. Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM. PMID: 31621579.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Diesel exhaust particles dysregulate multiple immunological pathways in murine macrophages: Lessons from microarray and scRNA-seq technologies. Arch Biochem Biophys. 2019 12 15; 678:108116. Bhetraratana M, Orozco LD, Hong J, Diamante G, Majid S, Bennett BJ, Ahn IS, Yang X, Lusis AJ, Araujo JA. PMID: 31568751.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. Sex-specific metabolic functions of adipose Lipocalin-2. Mol Metab. 2019 12; 30:30-47. Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ. PMID: 31767179.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    23. Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits. Am J Hum Genet. 2019 10 03; 105(4):773-787. Raulerson CK, Ko A, Kidd JC, Currin KW, Brotman SM, Cannon ME, Wu Y, Spracklen CN, Jackson AU, Stringham HM, Welch RP, Fuchsberger C, Locke AE, Narisu N, Lusis AJ, Civelek M, Furey TS, Kuusisto J, Collins FS, Boehnke M, Scott LJ, Lin DY, Love MI, Laakso M, Pajukanta P, Mohlke KL. PMID: 31564431.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. Mol Cell. 2019 08 08; 75(3):644-660.e5. Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY, Ji Y, Li C, Guo L, Zhou L, Chen Z, Leon-Mimila P, Chung MT, Kurabayashi K, Opp J, Campos-Pérez F, Villamil-Ramírez H, Canizales-Quinteros S, Lyons R, Lumeng CN, Zhou B, Qi L, Huertas-Vazquez A, Lusis AJ, Xu XZS, Li S, Yu Y, Li JZ, Lin JD. PMID: 31398325.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    25. Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition. Cell Host Microbe. 2019 08 14; 26(2):252-264.e10. Thingholm LB, Rühlemann MC, Koch M, Fuqua B, Laucke G, Boehm R, Bang C, Franzosa EA, Hübenthal M, Rahnavard A, Frost F, Lloyd-Price J, Schirmer M, Lusis AJ, Vulpe CD, Lerch MM, Homuth G, Kacprowski T, Schmidt CO, Nöthlings U, Karlsen TH, Lieb W, Laudes M, Franke A, Huttenhower C. PMID: 31399369.
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    26. Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis. Front Cardiovasc Med. 2019; 6:100. Wang J, Huertas-Vazquez A, Wang Y, Lusis AJ. PMID: 31417910.
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    27. Diesel Exhaust Induces Mitochondrial Dysfunction, Hyperlipidemia, and Liver Steatosis. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1776-1786. Yin F, Gupta R, Vergnes L, Driscoll WS, Ricks J, Ramanathan G, Stewart JA, Shih DM, Faull KF, Beaven SW, Lusis AJ, Reue K, Rosenfeld ME, Araujo JA. PMID: 31340670.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure. Nat Commun. 2019 06 24; 10(1):2760. Cordero P, Parikh VN, Chin ET, Erbilgin A, Gloudemans MJ, Shang C, Huang Y, Chang AC, Smith KS, Dewey F, Zaleta K, Morley M, Brandimarto J, Glazer N, Waggott D, Pavlovic A, Zhao M, Moravec CS, Tang WHW, Skreen J, Malloy C, Hannenhalli S, Li H, Ritter S, Li M, Bernstein D, Connolly A, Hakonarson H, Lusis AJ, Margulies KB, Depaoli-Roach AA, Montgomery SB, Wheeler MT, Cappola T, Ashley EA. PMID: 31235787.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    29. Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease. J Am Coll Cardiol. 2019 06 18; 73(23):2946-2957. Zeng L, Talukdar HA, Koplev S, Giannarelli C, Ivert T, Gan LM, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Michoel T, Schunkert H, Björkegren JLM. PMID: 31196451.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    30. XX sex chromosome complement promotes atherosclerosis in mice. Nat Commun. 2019 06 14; 10(1):2631. AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM, Petriello M, Deng P, Morris AJ, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson K, Tso P, Cassis LA. PMID: 31201301.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    31. Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance. Diabetes. 2019 09; 68(9):1730-1746. Zhou M, Shao J, Wu CY, Shu L, Dong W, Liu Y, Chen M, Wynn RM, Wang J, Wang J, Gui WJ, Qi X, Lusis AJ, Li Z, Wang W, Ning G, Yang X, Chuang DT, Wang Y, Sun H. PMID: 31167878.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    32. Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report. Arterioscler Thromb Vasc Biol. 2019 06; 39(6):1045-1054. Shih DM, Zhu W, Schugar RC, Meng Y, Jia X, Miikeda A, Wang Z, Zieger M, Lee R, Graham M, Allayee H, Cantor RM, Mueller C, Brown JM, Hazen SL, Lusis AJ. PMID: 31070450.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    33. Noggin depletion in adipocytes promotes obesity in mice. Mol Metab. 2019 07; 25:50-63. Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI. PMID: 31027994.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    34. Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. Mol Metab. 2019 06; 24:44-63. Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ. PMID: 30948248.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    35. An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 03; 567(7747):187-193. Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. PMID: 30814737.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. Antioxidants (Basel). 2019 Jan 11; 8(1). Shih DM, Meng Y, Sallam T, Vergnes L, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST. PMID: 30641857.
      View in: PubMed   Mentions:
    37. Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. Cell Metab. 2019 04 02; 29(4):932-949.e4. Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ. PMID: 30639359.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    38. Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity. J Lipid Res. 2019 03; 60(3):594-608. Pamir N, Pan C, Plubell DL, Hutchins PM, Tang C, Wimberger J, Irwin A, Vallim TQA, Heinecke JW, Lusis AJ. PMID: 30622162.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    39. Systems-based approaches for investigation of inter-tissue communication. J Lipid Res. 2019 03; 60(3):450-455. Seldin MM, Lusis AJ. PMID: 30617149.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    40. A comparison between whole transcript and 3' RNA sequencing methods using Kapa and Lexogen library preparation methods. BMC Genomics. 2019 Jan 07; 20(1):9. Ma F, Fuqua BK, Hasin Y, Yukhtman C, Vulpe CD, Lusis AJ, Pellegrini M. PMID: 30616562.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    41. Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring. Front Genet. 2018; 9:642. Martin LJ, Meng Q, Blencowe M, Lagarrigue S, Xiao S, Pan C, Wier J, Temple WC, Devaskar SU, Lusis AJ, Yang X. PMID: 30619467.
      View in: PubMed   Mentions:
    42. Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome. mBio. 2018 12 11; 9(6). Lang JM, Pan C, Cantor RM, Tang WHW, Garcia-Garcia JC, Kurtz I, Hazen SL, Bergeron N, Krauss RM, Lusis AJ. PMID: 30538180.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. PMID: 30591411.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. The E3 ligase MARCH5 is a PPAR? target gene that regulates mitochondria and metabolism in adipocytes. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E293-E304. Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG. PMID: 30512991.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    45. The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice. Hepatology. 2018 12; 68(6):2182-2196. Hui ST, Kurt Z, Tuominen I, Norheim F, C Davis R, Pan C, Dirks DL, Magyar CE, French SW, Chella Krishnan K, Sabir S, Campos-Pérez F, Méndez-Sánchez N, Macías-Kauffer L, León-Mimila P, Canizales-Quinteros S, Yang X, Beaven SW, Huertas-Vazquez A, Lusis AJ. PMID: 29907965.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    46. Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans. G3 (Bethesda). 2018 11 06; 8(11):3499-3506. Lin LY, Chun Chang S, O'Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A. PMID: 30201759.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    47. Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model. Nat Microbiol. 2018 12; 3(12):1461-1471. Kasahara K, Krautkramer KA, Org E, Romano KA, Kerby RL, Vivas EI, Mehrabian M, Denu JM, Bäckhed F, Lusis AJ, Rey FE. PMID: 30397344.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    48. Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis. EMBO Rep. 2018 12; 19(12). Rotter D, Peiris H, Grinsfelder DB, Martin AM, Burchfield J, Parra V, Hull C, Morales CR, Jessup CF, Matusica D, Parks BW, Lusis AJ, Nguyen NUN, Oh M, Iyoke I, Jakkampudi T, McMillan DR, Sadek HA, Watt MJ, Gupta RK, Pritchard MA, Keating DJ, Rothermel BA. PMID: 30389725.
      View in: PubMed   Mentions:
    49. Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet. 2018 10; 14(10):e1007732. Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. PMID: 30372444.
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    105. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016 08 04; 536(7614):86-90. Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. PMID: 27437576.
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    106. Chromatin variation associated with liver metabolism is mediated by transposable elements. Epigenetics Chromatin. 2016; 9:28. Du J, Leung A, Trac C, Lee M, Parks BW, Lusis AJ, Natarajan R, Schones DE. PMID: 27398095.
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    107. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet. 2016 07; 12(7):e1006038. Wang JJ, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, Lusis AJ. PMID: 27385019.
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    108. Sex differences and hormonal effects on gut microbiota composition in mice. Gut Microbes. 2016 07 03; 7(4):313-322. Org E, Mehrabian M, Parks BW, Shipkova P, Liu X, Drake TA, Lusis AJ. PMID: 27355107.
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    109. Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. Physiol Genomics. 2016 08 01; 48(8):601-15. Karbassi E, Monte E, Chapski DJ, Lopez R, Rosa Garrido M, Kim J, Wisniewski N, Rau CD, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Vondriska TM. PMID: 27287924.
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    110. Imputing Phenotypes for Genome-wide Association Studies. Am J Hum Genet. 2016 Jul 07; 99(1):89-103. Hormozdiari F, Kang EY, Bilow M, Ben-David E, Vulpe C, McLachlan S, Lusis AJ, Han B, Eskin E. PMID: 27292110.
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    111. Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J Biol Chem. 2016 07 22; 291(30):15428-46. Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, Vondriska TM. PMID: 27226577.
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    112. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 06; 57(6):925-42. Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. PMID: 27099397.
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    113. Skeletal muscle action of estrogen receptor a is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med. 2016 Apr 13; 8(334):334ra54. Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL. PMID: 27075628.
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    114. Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell. 2016 Mar 24; 165(1):111-124. Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL. PMID: 26972052.
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    116. Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease. Cell Syst. 2016 03 23; 2(3):196-208. Talukdar HA, Foroughi Asl H, Jain RK, Ermel R, Ruusalepp A, Franzén O, Kidd BA, Readhead B, Giannarelli C, Kovacic JC, Ivert T, Dudley JT, Civelek M, Lusis AJ, Schadt EE, Skogsberg J, Michoel T, Björkegren JL. PMID: 27135365.
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    117. Correction: Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains. PLoS Genet. 2016 Mar; 12(3):e1005913. Bennett BJ, Davis RC, Civelek M, Orozco L, Wu J, Qi H, Pan C, Sevag Packard RR, Eskin E, Yan M, Kirchgessner T, Wang Z, Li X, Gregory JC, Hazen SL, Gargalovic PS, Lusis AJ. PMID: 26934746.
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    118. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-?B. J Am Heart Assoc. 2016 Feb 22; 5(2). Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. PMID: 26903003.
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    124. Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. Am J Hum Genet. 2015 Dec 03; 97(6):801-15. Roman TS, Marvelle AF, Fogarty MP, Vadlamudi S, Gonzalez AJ, Buchkovich ML, Huyghe JR, Fuchsberger C, Jackson AU, Wu Y, Civelek M, Lusis AJ, Gaulton KJ, Sethupathy P, Kangas AJ, Soininen P, Ala-Korpela M, Kuusisto J, Collins FS, Laakso M, Boehnke M, Mohlke KL. PMID: 26637976.
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    125. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. J Exp Med. 2015 Nov 16; 212(12):2147-63. Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML. PMID: 26552708.
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    126. Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30; 290(44):26699-714. Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG. PMID: 26359501.
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    127. The Genetic Architecture of Hearing Impairment in Mice: Evidence for Frequency-Specific Genetic Determinants. G3 (Bethesda). 2015 Sep 04; 5(11):2329-39. Crow AL, Ohmen J, Wang J, Lavinsky J, Hartiala J, Li Q, Li X, Salehide P, Eskin E, Pan C, Lusis AJ, Allayee H, Friedman RA. PMID: 26342000.
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    128. Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler Thromb Vasc Biol. 2015 Oct; 35(10):2207-17. Brænne I, Civelek M, Vilne B, Di Narzo A, Johnson AD, Zhao Y, Reiz B, Codoni V, Webb TR, Foroughi Asl H, Hamby SE, Zeng L, Trégouët DA, Hao K, Topol EJ, Schadt EE, Yang X, Samani NJ, Björkegren JL, Erdmann J, Schunkert H, Lusis AJ. PMID: 26293461.
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    129. Genetic and environmental control of host-gut microbiota interactions. Genome Res. 2015 Oct; 25(10):1558-69. Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis AJ. PMID: 26260972.
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    130. High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. G3 (Bethesda). 2015 Jul 28; 5(10):2021-6. Rau CD, Parks B, Wang Y, Eskin E, Simecek P, Churchill GA, Lusis AJ. PMID: 26224782.
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    131. Quantitative analysis of 3-dimensional facial soft tissue photographic images: technical methods and clinical application. Prog Orthod. 2015; 16:21. Nanda V, Gutman B, Bar E, Alghamdi S, Tetradis S, Lusis AJ, Eskin E, Moon W. PMID: 26133934.
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    132. Cardiovascular disease genes come together. Atherosclerosis. 2015 Oct; 242(2):630-1. Lusis AJ. PMID: 26152393.
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    133. The genetic architecture of NAFLD among inbred strains of mice. Elife. 2015 Jun 12; 4:e05607. Hui ST, Parks BW, Org E, Norheim F, Che N, Pan C, Castellani LW, Charugundla S, Dirks DL, Psychogios N, Neuhaus I, Gerszten RE, Kirchgessner T, Gargalovic PS, Lusis AJ. PMID: 26067236.
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    134. Correction: Genome-Wide Association Study Identifies Nox3 as a Critical Gene for Susceptibility to Noise-Induced Hearing Loss. PLoS Genet. 2015 Jun; 11(6):e1005293. Lavinsky J, Crow AL, Pan C, Wang J, Aaron KA, Ho MK, Li Q, Salehide P, Myint A, Monges-Hernadez M, Eskin E, Allayee H, Lusis AJ, Friedman RA. PMID: 26068505.
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    135. The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice. Stem Cell Reports. 2015 Jul 14; 5(1):125-38. Zhou X, Crow AL, Hartiala J, Spindler TJ, Ghazalpour A, Barsky LW, Bennett BJ, Parks BW, Eskin E, Jain R, Epstein JA, Lusis AJ, Adams GB, Allayee H. PMID: 26050929.
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    137. Epigenome-wide association of liver methylation patterns and complex metabolic traits in mice. Cell Metab. 2015 Jun 02; 21(6):905-17. Orozco LD, Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis AJ, Pellegrini M. PMID: 26039453.
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    139. Genetics of common forms of heart failure: challenges and potential solutions. Curr Opin Cardiol. 2015 May; 30(3):222-7. Rau CD, Lusis AJ, Wang Y. PMID: 25768955.
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    140. Scavenger receptor class A member 5 (SCARA5) and suprabasin (SBSN) are hub genes of coexpression network modules associated with peripheral vein graft patency. J Vasc Surg. 2016 07; 64(1):202-209.e6. Kenagy RD, Civelek M, Kikuchi S, Chen L, Grieff A, Sobel M, Lusis AJ, Clowes AW. PMID: 25935274.
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    143. ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney. FEBS Open Bio. 2015; 5:257-63. Blazquez-Medela AM, Guihard PJ, Yao J, Jumabay M, Lusis AJ, Boström KI, Yao Y. PMID: 25893161.
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    145. Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation. G3 (Bethesda). 2015 Feb 03; 5(4):517-29. Roux PF, Boitard S, Blum Y, Parks B, Montagner A, Mouisel E, Djari A, Esquerré D, Désert C, Boutin M, Leroux S, Lecerf F, Le Bihan-Duval E, Klopp C, Servin B, Pitel F, Duclos MJ, Guillou H, Lusis AJ, Demeure O, Lagarrigue S. PMID: 25653314.
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    146. The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance. Cell Rep. 2015 Jan 20; 10(3):326-338. Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. PMID: 25600868.
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    148. Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. Circ Cardiovasc Genet. 2015 Feb; 8(1):40-9. Rau CD, Wang J, Avetisyan R, Romay MC, Martin L, Ren S, Wang Y, Lusis AJ. PMID: 25480693.
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    149. PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J. 2015 Apr; 29(4):1185-97. Shih DM, Yu JM, Vergnes L, Dali-Youcef N, Champion MD, Devarajan A, Zhang P, Castellani LW, Brindley DN, Jamey C, Auwerx J, Reddy ST, Ford DA, Reue K, Lusis AJ. PMID: 25477283.
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    150. Estrogen receptor (ER)a-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. J Biol Chem. 2015 Feb 27; 290(9):5566-81. Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL. PMID: 25468909.
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    151. Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response. FASEB J. 2015 Feb; 29(2):636-49. van Stijn CM, Kim J, Lusis AJ, Barish GD, Tangirala RK. PMID: 25392268.
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    152. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015 Jan; 56(1):22-37. Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ. PMID: 25378658.
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    153. Shared molecular pathways and gene networks for cardiovascular disease and type 2 diabetes mellitus in women across diverse ethnicities. Circ Cardiovasc Genet. 2014 Dec; 7(6):911-9. Chan KH, Huang YT, Meng Q, Wu C, Reiner A, Sobel EM, Tinker L, Lusis AJ, Yang X, Liu S. PMID: 25371518.
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    154. ?-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 04; 20(5):799-812. Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. PMID: 25440057.
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    155. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826. Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. PMID: 25440058.
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    156. Genetic modulation of diabetic nephropathy among mouse strains with Ins2 Akita mutation. Physiol Rep. 2014 Nov 01; 2(11). Wu X, Davis RC, McMillen TS, Schaeffer V, Zhou Z, Qi H, Mazandarani PN, Alialy R, Hudkins KL, Lusis AJ, LeBoeuf RC. PMID: 25428948.
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    157. Regulation of NF-?B signaling by oxidized glycerophospholipid and IL-1ß induced miRs-21-3p and -27a-5p in human aortic endothelial cells. J Lipid Res. 2015 Jan; 56(1):38-50. Romay MC, Che N, Becker SN, Pouldar D, Hagopian R, Xiao X, Lusis AJ, Berliner JA, Civelek M. PMID: 25327529.
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