Elaine Yih-Nien Hsiao

Title(s)Associate Professor, Integrative Biology And Physiology
SchoolCollege of Letters and Science
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    Other Positions
    Title(s)Associate Professor, MIMG


    Collapse Research 
    Collapse Research Activities and Funding
    Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet
    NIH R01NS115537May 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Uncovering microbial modulators of neuroactive molecules
    NIH DP5OD017924Sep 19, 2013 - Aug 31, 2019
    Role: Principal Investigator
    Functional Role of IL-6 in Fetal Brain Development and Abnormal Behavior
    NIH F31MH090749Sep 30, 2011 - Sep 29, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The maternal microbiome promotes placental development in mice. bioRxiv. 2023 Feb 15. Pronovost GN, Telang SS, Chen AS, Coley EJL, Vuong HE, Williams DW, Yu KB, Rendon TK, Paramo J, Kim RH, Hsiao EY. PMID: 36824779; PMCID: PMC9948959.
      View in: PubMed   Mentions:
    2. Extending genetic risk for Alzheimer's disease from host to holobiont. Cell. 2023 Feb 06. Kazmi SA, Hsiao EY. PMID: 36750093.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    3. Gut microbiota: A sweet tale of mice and microbes. Curr Biol. 2023 01 09; 33(1):R18-R20. Yu KB, Hsiao EY. PMID: 36626856.
      View in: PubMed   Mentions:    Fields:    
    4. Gut microbes shape athletic motivation. Nature. 2022 12; 612(7941):633-634. Agirman G, Hsiao EY. PMID: 36517676.
      View in: PubMed   Mentions:    Fields:    
    5. STENSL: Microbial Source Tracking with ENvironment SeLection. mSystems. 2022 10 26; 7(5):e0099521. An U, Shenhav L, Olson CA, Hsiao EY, Halperin E, Sankararaman S. PMID: 36047699; PMCID: PMC9599664.
      View in: PubMed   Mentions:
    6. Interactions between the gut microbiome and ketogenic diet in refractory epilepsy. Int Rev Neurobiol. 2022; 167:217-249. ?zcan E, Lum GR, Hsiao EY. PMID: 36427956.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Are changes in the gut microbiome a contributor or consequence of autism-why not both? Cell Rep Med. 2022 01 18; 3(1):100505. Özcan E, Hsiao EY. PMID: 35106514; PMCID: PMC8784764.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. The Gut Microbiome as a Regulator of the Neuroimmune Landscape. Annu Rev Immunol. 2022 04 26; 40:143-167. Yu LW, Agirman G, Hsiao EY. PMID: 34990209.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    9. Signaling inflammation across the gut-brain axis. Science. 2021 Nov 26; 374(6571):1087-1092. Agirman G, Yu KB, Hsiao EY. PMID: 34822299.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    10. Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia. Cell Host Microbe. 2021 09 08; 29(9):1378-1392.e6. Olson CA, Iñiguez AJ, Yang GE, Fang P, Pronovost GN, Jameson KG, Rendon TK, Paramo J, Barlow JT, Ismagilov RF, Hsiao EY. PMID: 34358434; PMCID: PMC8429275.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    11. Malnutrition and the microbiome as modifiers of early neurodevelopment. Trends Neurosci. 2021 09; 44(9):753-764. Coley EJL, Hsiao EY. PMID: 34303552.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Early life adversity predicts brain-gut alterations associated with increased stress and mood. Neurobiol Stress. 2021 Nov; 15:100348. Coley EJL, Mayer EA, Osadchiy V, Chen Z, Subramanyam V, Zhang Y, Hsiao EY, Gao K, Bhatt R, Dong T, Vora P, Naliboff B, Jacobs JP, Gupta A. PMID: 34113697; PMCID: PMC8170500.
      View in: PubMed   Mentions: 4  
    13. Roles for the gut microbiota in regulating neuronal feeding circuits. J Clin Invest. 2021 05 17; 131(10). Yu KB, Hsiao EY. PMID: 33998595; PMCID: PMC8121503.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    14. Interactions between maternal fluoxetine exposure, the maternal gut microbiome and fetal neurodevelopment in mice. Behav Brain Res. 2021 07 23; 410:113353. Vuong HE, Coley EJL, Kazantsev M, Cooke ME, Rendon TK, Paramo J, Hsiao EY. PMID: 33979656.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. SnapShot: The microbiota-gut-brain axis. Cell. 2021 04 29; 184(9):2524-2524.e1. Agirman G, Hsiao EY. PMID: 33930299.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    16. Gut microbial taxa elevated by dietary sugar disrupt memory function. Transl Psychiatry. 2021 03 31; 11(1):194. Noble EE, Olson CA, Davis E, Tsan L, Chen YW, Schade R, Liu C, Suarez A, Jones RB, de La Serre C, Yang X, Hsiao EY, Kanoski SE. PMID: 33790226; PMCID: PMC8012713.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    17. IL-33 Changes Our "Gut Feelings" about Serotonin. Immunity. 2021 01 12; 54(1):9-11. Yu LW, Hsiao EY. PMID: 33440138.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Analysis of brain networks and fecal metabolites reveals brain-gut alterations in premenopausal females with irritable bowel syndrome. Transl Psychiatry. 2020 11 02; 10(1):367. Osadchiy V, Mayer EA, Gao K, Labus JS, Naliboff B, Tillisch K, Chang L, Jacobs JP, Hsiao EY, Gupta A. PMID: 33139708; PMCID: PMC7608552.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    19. Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice. J Nutr. 2020 10 12; 150(10):2716-2728. Ahn IS, Lang JM, Olson CA, Diamante G, Zhang G, Ying Z, Byun HR, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis AJ, Hsiao EY, Yang X. PMID: 32856048; PMCID: PMC7549307.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    20. The maternal microbiome modulates fetal neurodevelopment in mice. Nature. 2020 10; 586(7828):281-286. Vuong HE, Pronovost GN, Williams DW, Coley EJL, Siegler EL, Qiu A, Kazantsev M, Wilson CJ, Rendon T, Hsiao EY. PMID: 32968276; PMCID: PMC7554197.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    21. The Microbiome as a Modifier of Neurodegenerative Disease Risk. Cell Host Microbe. 2020 08 12; 28(2):201-222. Fang P, Kazmi SA, Jameson KG, Hsiao EY. PMID: 32791113; PMCID: PMC7430034.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    22. Ketone Bodies Exert Ester-Ordinary Suppression of Bifidobacteria and Th17 Cells. Cell Metab. 2020 06 02; 31(6):1049-1051. Olson CA, Lum GR, Hsiao EY. PMID: 32492391.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    23. Gut microbes tune inflammation and lifespan in a mouse model of amyotrophic lateral sclerosis. Nature. 2020 06; 582(7810):34-35. Fang P, Hsiao EY. PMID: 32405038.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. Toward Understanding Microbiome-Neuronal Signaling. Mol Cell. 2020 05 21; 78(4):577-583. Jameson KG, Olson CA, Kazmi SA, Hsiao EY. PMID: 32275853.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    25. Indigenous Microbiota Protects against Inflammation-Induced Osteonecrosis. J Dent Res. 2020 06; 99(6):676-684. Williams DW, Vuong HE, Kim S, Lenon A, Ho K, Hsiao EY, Sung EC, Kim RH. PMID: 32109361; PMCID: PMC7243424.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    26. Mitochondrial and Purinergic Dysregulation Promote Abnormal Behavior in Mice. Trends Immunol. 2020 02; 41(2):97-99. Fang P, Hsiao EY. PMID: 31948872.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. Microbiomes as sources of emergent host phenotypes. Science. 2019 09 27; 365(6460):1405-1409. Lynch JB, Hsiao EY. PMID: 31604267.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimals
    28. Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut. Nat Microbiol. 2019 12; 4(12):2064-2073. Fung TC, Vuong HE, Luna CDG, Pronovost GN, Aleksandrova AA, Riley NG, Vavilina A, McGinn J, Rendon T, Forrest LR, Hsiao EY. PMID: 31477894; PMCID: PMC6879823.
      View in: PubMed   Mentions: 111     Fields:    Translation:AnimalsCells
    29. Emerging roles for the intestinal microbiome in epilepsy. Neurobiol Dis. 2020 02; 135:104576. Lum GR, Olson CA, Hsiao EY. PMID: 31445165.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    30. A novel pathway for microbial metabolism of levodopa. Nat Med. 2019 08; 25(8):1195-1197. Jameson KG, Hsiao EY. PMID: 31388180; PMCID: PMC7004239.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis. Microbiome. 2019 03 21; 7(1):45. Labus JS, Osadchiy V, Hsiao EY, Tap J, Derrien M, Gupta A, Tillisch K, Le Nevé B, Grinsvall C, Ljungberg M, Öhman L, Törnblom H, Simren M, Mayer EA. PMID: 30898151; PMCID: PMC6429755.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    32. Gut Microbes Join the Social Network. Neuron. 2019 01 16; 101(2):196-198. Vuong HE, Hsiao EY. PMID: 30653931; PMCID: PMC6661156.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    33. Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment. Immunity. 2019 01 15; 50(1):18-36. Pronovost GN, Hsiao EY. PMID: 30650376; PMCID: PMC6447295.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    34. Defining Dysbiosis in Disorders of Movement and Motivation. J Neurosci. 2018 10 31; 38(44):9414-9422. Fields CT, Sampson TR, Bruce-Keller AJ, Kiraly DD, Hsiao EY, de Vries GJ. PMID: 30381433; PMCID: PMC6209841.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    35. The gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence. Neuropsychopharmacology. 2018 12; 43(13):2606-2614. Lee K, Vuong HE, Nusbaum DJ, Hsiao EY, Evans CJ, Taylor AMW. PMID: 30258112; PMCID: PMC6224506.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    36. Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model. Neuropsychopharmacology. 2019 01; 44(2):245-258. Kentner AC, Bilbo SD, Brown AS, Hsiao EY, McAllister AK, Meyer U, Pearce BD, Pletnikov MV, Yolken RH, Bauman MD. PMID: 30188509; PMCID: PMC6300528.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    37. Correlation of tryptophan metabolites with connectivity of extended central reward network in healthy subjects. PLoS One. 2018; 13(8):e0201772. Osadchiy V, Labus JS, Gupta A, Jacobs J, Ashe-McNalley C, Hsiao EY, Mayer EA. PMID: 30080865; PMCID: PMC6078307.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    38. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell. 2018 07 12; 174(2):497. Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY. PMID: 30007420; PMCID: PMC6062008.
      View in: PubMed   Mentions: 52     Fields:    
    39. Linking the Gut Microbiota to a Brain Neurotransmitter. Trends Neurosci. 2018 07; 41(7):413-414. Jameson KG, Hsiao EY. PMID: 29933773; PMCID: PMC7004240.
      View in: PubMed   Mentions: 23     Fields:    
    40. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell. 2018 06 14; 173(7):1728-1741.e13. Olson CA, Vuong HE, Yano JM, Liang QY, Nusbaum DJ, Hsiao EY. PMID: 29804833; PMCID: PMC6003870.
      View in: PubMed   Mentions: 280     Fields:    Translation:AnimalsCells
    41. Microbes REV up Host Metabolism around the Clock. Immunity. 2017 10 17; 47(4):618-620. Pronovost GN, Hsiao EY. PMID: 29045896.
      View in: PubMed   Mentions:    Fields:    
    42. The Gut and Its Microbiome as Related to Central Nervous System Functioning and Psychological Well-being: Introduction to the Special Issue of Psychosomatic Medicine. Psychosom Med. 2017 Oct; 79(8):844-846. Mayer EA, Hsiao EY. PMID: 28976454; PMCID: PMC5924442.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    43. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017 05 01; 5(1):49. Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. PMID: 28457228; PMCID: PMC5410709.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    44. The Microbiome and Host Behavior. Annu Rev Neurosci. 2017 07 25; 40:21-49. Vuong HE, Yano JM, Fung TC, Hsiao EY. PMID: 28301775; PMCID: PMC6661159.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimals
    45. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017 02; 20(2):145-155. Fung TC, Olson CA, Hsiao EY. PMID: 28092661; PMCID: PMC6960010.
      View in: PubMed   Mentions: 571     Fields:    Translation:HumansAnimals
    46. The placental interleukin-6 signaling controls fetal brain development and behavior. Brain Behav Immun. 2017 May; 62:11-23. Wu WL, Hsiao EY, Yan Z, Mazmanian SK, Patterson PH. PMID: 27838335; PMCID: PMC5373986.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    47. Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder. Biol Psychiatry. 2017 03 01; 81(5):411-423. Vuong HE, Hsiao EY. PMID: 27773355; PMCID: PMC5285286.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansAnimals
    48. The Microbial Olympics 2016. Nat Microbiol. 2016 07 26; 1(8):16122. Nelson MB, Chase AB, Martiny JB, Stocker R, Nguyen J, Lloyd K, Oshiro RT, Kearns DB, Schneider JP, Ringel PD, Basler M, Olson CA, Vuong HE, Hsiao EY, Roller BR, Ackermann M, Smillie C, Chien D, Alm E, Jermy AJ. PMID: 27573121; PMCID: PMC6961809.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    49. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015 Apr 09; 161(2):264-76. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. PMID: 25860609; PMCID: PMC4393509.
      View in: PubMed   Mentions: 1011     Fields:    Translation:HumansAnimalsCells
    50. Gastrointestinal issues in autism spectrum disorder. Harv Rev Psychiatry. 2014 Mar-Apr; 22(2):104-11. Hsiao EY. PMID: 24614765.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    51. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. 2013 Dec 19; 155(7):1451-63. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK. PMID: 24315484; PMCID: PMC3897394.
      View in: PubMed   Mentions: 1188     Fields:    Translation:HumansAnimalsCells
    52. Immune dysregulation in autism spectrum disorder. Int Rev Neurobiol. 2013; 113:269-302. Hsiao EY. PMID: 24290389.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    53. Placental regulation of maternal-fetal interactions and brain development. Dev Neurobiol. 2012 Oct; 72(10):1317-26. Hsiao EY, Patterson PH. PMID: 22753006.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
    54. Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development. Brain Behav Immun. 2013 Jul; 31:54-68. Garay PA, Hsiao EY, Patterson PH, McAllister AK. PMID: 22841693; PMCID: PMC3529133.
      View in: PubMed   Mentions: 144     Fields:    Translation:Animals
    55. Modeling an autism risk factor in mice leads to permanent immune dysregulation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12776-81. Hsiao EY, McBride SW, Chow J, Mazmanian SK, Patterson PH. PMID: 22802640; PMCID: PMC3411999.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansAnimalsCells
    56. Effects of maternal immune activation on gene expression patterns in the fetal brain. Transl Psychiatry. 2012 Apr 03; 2:e98. Garbett KA, Hsiao EY, Kálmán S, Patterson PH, Mirnics K. PMID: 22832908; PMCID: PMC3337077.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    57. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav Immun. 2012 May; 26(4):607-16. Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH. PMID: 22310922; PMCID: PMC3322300.
      View in: PubMed   Mentions: 273     Fields:    Translation:Animals
    58. Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav Immun. 2011 May; 25(4):604-15. Hsiao EY, Patterson PH. PMID: 21195166; PMCID: PMC3081363.
      View in: PubMed   Mentions: 163     Fields:    Translation:AnimalsCellsPHPublic Health
    59. Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring. Brain Behav Immun. 2010 Aug; 24(6):930-41. Ito HT, Smith SE, Hsiao E, Patterson PH. PMID: 20227486; PMCID: PMC2897971.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
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