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Sriram Sankararaman

Title(s)Professor, Computer Science
SchoolHenry Samueli School of Engineering and Applied Science
Emailsriram@cs.ucla.edu
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    Other Positions
    Title(s)Professor, Human Genetics

    Title(s)Professor, Computational Medicine


    Collapse Research 
    Collapse research activities and funding
    An Autonomous, Non-invasive, and Bioanalytics-enabled Wearable Platform for Precision Nutrition and Personalized Medicine
    NIH R21DK128711May 24, 2021 - Apr 30, 2023
    Role: Co-Principal Investigator
    Statistical Models for Dissecting Human Population Admixture and its Role in Evolution and Disease
    NIH R35GM125055Sep 1, 2017 - Aug 31, 2022
    Role: Principal Investigator
    Statistical methods to infer structure and impact of ancient admixture
    NIH R00GM111744Sep 15, 2014 - Dec 31, 2018
    Role: Principal Investigator
    Statistical methods to infer structure and impact of ancient admixture
    NIH K99GM111744Sep 15, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Epigenetic patient stratification reveals a sub-endotype of type 2 asthma with altered B-cell response. medRxiv. 2025 Sep 02. Gorla A, Witonsky J, Chen ZJ, Elhawary JR, Mefford J, Perez-Garcia J, Madore AM, Huntsman S, Hu D, Eng C, Bhakta NR, Woodruff PG, Laprise C, Sankararaman S, Flint J, Allen CDC, Ziv E, Zaitlen N, Burchard E, Rahmani E. PMID: 40950420; PMCID: PMC12424920.
      View in: PubMed   Mentions:
    2. Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue. Nat Genet. 2025 Aug 20. Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna KD, Alvarez M, Sukhatme MG, Wang Z, Gelev KZ, Heffel MG, Zhang Y, Avram O, Rahmani E, Sankararaman S, Laakso M, Heinonen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P. PMID: 40835891; PMCID: PMC12373012.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Fast variance component analysis using large-scale ancestral recombination graphs. bioRxiv. 2025 Jul 24. Zhu J, Kalantzis G, Pazokitoroudi A, Gunnarsson ÁF, Loya H, Chen H, Sankararaman S, Palamara PF. PMID: 40777390; PMCID: PMC12330685.
      View in: PubMed   Mentions:
    4. Identifying common disease trajectories of Alzheimer's disease with electronic health records. EBioMedicine. 2025 Aug; 118:105831. Fu M, Sankararaman S, Pasaniuc B, Vossel K, Chang TS. PMID: 40592257; PMCID: PMC12266379.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions. Nat Commun. 2025 Jun 05; 16(1):5223. Wei A, Border R, Fu B, Cullina S, Brandes N, Jang SK, Sankararaman S, Kenny EE, Udler MS, Ntranos V, Zaitlen N, Arboleda VA. PMID: 40473624; PMCID: PMC12141715.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Identifying Common Disease Trajectories of Progressive Supranuclear Palsy with Electronic Health Records. Mov Disord Clin Pract. 2025 May 09. Fu M, Sankararaman S, Vossel KA, Chang TS. PMID: 40344390.
      View in: PubMed   Mentions:    Fields:    
    7. Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations. bioRxiv. 2025 May 07. Zhang X, Yang J, Zhu L, Sachdev N, Mooney J, Sankararaman S, Lohmueller KE. PMID: 40654668; PMCID: PMC12248111.
      View in: PubMed   Mentions:
    8. dotears: Scalable and consistent directed acyclic graph estimation using observational and interventional data. iScience. 2025 Feb 21; 28(2):111673. Xue A, Rao J, Sankararaman S, Pimentel H. PMID: 39944273; PMCID: PMC11814701.
      View in: PubMed   Mentions:
    9. Characterizing the genetic architecture of drug response using gene-context interaction methods. Cell Genom. 2024 Dec 11; 4(12):100722. Sadowski M, Thompson M, Mefford J, Haldar T, Oni-Orisan A, Border R, Pazokitoroudi A, Cai N, Ayroles JF, Sankararaman S, Dahl AW, Zaitlen N. PMID: 39637863; PMCID: PMC11701255.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    10. Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue. bioRxiv. 2024 Nov 03. Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna KD, Alvarez M, Sukhatme MG, Gelev KZ, Heffel MG, Zhang Y, Avram O, Rahmani E, Sankararaman S, Heinonen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P. PMID: 39554055; PMCID: PMC11566006.
      View in: PubMed   Mentions:
    11. Scalable summary-statistics-based heritability estimation method with individual genotype level accuracy. Genome Res. 2024 Oct 11; 34(9):1286-1293. Jeong M, Pazokitoroudi A, Liu Z, Sankararaman S. PMID: 39038848; PMCID: PMC11529871.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. A scalable adaptive quadratic kernel method for interpretable epistasis analysis in complex traits. Genome Res. 2024 Oct 11; 34(9):1294-1303. Fu B, Anand P, Anand A, Mefford J, Sankararaman S. PMID: 39209554; PMCID: PMC11529862.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Accurate prediction of disease-risk factors from volumetric medical scans by a deep vision model pre-trained with 2D scans. Nat Biomed Eng. 2025 Apr; 9(4):507-520. Avram O, Durmus B, Rakocz N, Corradetti G, An U, Nittala MG, Terway P, Rudas A, Chen ZJ, Wakatsuki Y, Hirabayashi K, Velaga S, Tiosano L, Corvi F, Verma A, Karamat A, Lindenberg S, Oncel D, Almidani L, Hull V, Fasih-Ahmad S, Esmaeilkhanian H, Cannesson M, Wykoff CC, Rahmani E, Arnold CW, Zhou B, Zaitlen N, Gronau I, Sankararaman S, Chiang JN, Sadda SR, Halperin E. PMID: 39354052.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Epigenetic patient stratification via contrastive machine learning refines hallmark biomarkers in minoritized children with asthma. Res Sq. 2024 Sep 13. Gorla A, Witonsky J, Elhawary JR, Chen ZJ, Mefford J, Perez-Garcia J, Huntsman S, Hu D, Eng C, Woodruff PG, Sankararaman S, Ziv E, Flint J, Zaitlen N, Burchard E, Rahmani E. PMID: 39315258; PMCID: PMC11419268.
      View in: PubMed   Mentions:
    15. VISTA: an integrated framework for structural variant discovery. Brief Bioinform. 2024 Jul 25; 25(5). Sarwal V, Lee S, Yang J, Sankararaman S, Chaisson M, Eskin E, Mangul S. PMID: 39297879; PMCID: PMC11411772.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits. Am J Hum Genet. 2024 07 11; 111(7):1462-1480. Pazokitoroudi A, Liu Z, Dahl A, Zaitlen N, Rosset S, Sankararaman S. PMID: 38866020; PMCID: PMC11267529.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. MANOCCA: a robust and computationally efficient test of covariance in high-dimension multivariate omics data. Brief Bioinform. 2024 May 23; 25(4). Boetto C, Frouin A, Henches L, Auvergne A, Suzuki Y, Patin E, Bredon M, Chiu A, Consortium MI, Sankararaman S, Zaitlen N, Kennedy SP, Quintana-Murci L, Duffy D, Sokol H, Aschard H. PMID: 38856173; PMCID: PMC11163461.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Investigating the sources of variable impact of pathogenic variants in monogenic metabolic conditions. medRxiv. 2024 May 01. Wei A, Border R, Fu B, Cullina S, Brandes N, Jang SK, Sankararaman S, Kenny E, Udler MS, Ntranos V, Zaitlen N, Arboleda V. PMID: 37745486; PMCID: PMC10516069.
      View in: PubMed   Mentions:
    19. Personalized mood prediction from patterns of behavior collected with smartphones. NPJ Digit Med. 2024 Feb 28; 7(1):49. Balliu B, Douglas C, Seok D, Shenhav L, Wu Y, Chatzopoulou D, Kaiser W, Chen V, Kim J, Deverasetty S, Arnaudova I, Gibbons R, Congdon E, Craske MG, Freimer N, Halperin E, Sankararaman S, Flint J. PMID: 38418551; PMCID: PMC10902386.
      View in: PubMed   Mentions: 8  
    20. A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits. bioRxiv. 2023 Dec 13. Pazokitoroudi A, Dahl A, Zaitlen N, Rosset S, Sankararaman S. PMID: 38168200; PMCID: PMC10760005.
      View in: PubMed   Mentions:
    21. SLIViT: a general AI framework for clinical-feature diagnosis from limited 3D biomedical-imaging data. Res Sq. 2023 Nov 21. Avram O, Durmus B, Rakocz N, Corradetti G, An U, Nitalla MG, Rudas A, Wakatsuki Y, Hirabayashi K, Velaga S, Tiosano L, Corvi F, Verma A, Karamat A, Lindenberg S, Oncel D, Almidani L, Hull V, Fasih-Ahmad S, Esmaeilkhanian H, Wykoff CC, Rahmani E, Arnold CW, Zhou B, Zaitlen N, Gronau I, Sankararaman S, Chiang JN, Sadda SR, Halperin E. PMID: 38045283; PMCID: PMC10690310.
      View in: PubMed   Mentions:
    22. Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries. Nat Genet. 2023 Dec; 55(12):2269-2276. An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S. PMID: 37985819; PMCID: PMC10703681.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    23. Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder. Nat Genet. 2023 Dec; 55(12):2082-2093. Dahl A, Thompson M, An U, Krebs M, Appadurai V, Border R, Bacanu SA, Werge T, Flint J, Schork AJ, Sankararaman S, Kendler KS, Cai N. PMID: 37985818; PMCID: PMC10703686.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    24. A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis. bioRxiv. 2023 Sep 12. Fu B, Pazokitoroudi A, Xue A, Anand A, Anand P, Zaitlen N, Sankararaman S. PMID: 37745394; PMCID: PMC10515811.
      View in: PubMed   Mentions:
    25. Fast kernel-based association testing of non-linear genetic effects for biobank-scale data. Nat Commun. 2023 08 15; 14(1):4936. Fu B, Pazokitoroudi A, Sudarshan M, Liu Z, Subramanian L, Sankararaman S. PMID: 37582955; PMCID: PMC10427662.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Tractable and Expressive Generative Models of Genetic Variation Data. bioRxiv. 2023 May 18. Dang M, Liu A, Wei X, Sankararaman S, Van den Broeck G. PMID: 37292742; PMCID: PMC10245670.
      View in: PubMed   Mentions:
    27. Leveraging family data to design Mendelian randomization that is provably robust to population stratification. Genome Res. 2023 07; 33(7):1032-1041. LaPierre N, Fu B, Turnbull S, Eskin E, Sankararaman S. PMID: 37197991; PMCID: PMC10538495.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    28. Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Nat Genet. 2023 04; 55(4):549-558. Hou K, Ding Y, Xu Z, Wu Y, Bhattacharya A, Mester R, Belbin GM, Buyske S, Conti DV, Darst BF, Fornage M, Gignoux C, Guo X, Haiman C, Kenny EE, Kim M, Kooperberg C, Lange L, Manichaikul A, North KE, Peters U, Rasmussen-Torvik LJ, Rich SS, Rotter JI, Wheeler HE, Wojcik GL, Zhou Y, Sankararaman S, Pasaniuc B. PMID: 36941441; PMCID: PMC11120833.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    29. The lingering effects of Neanderthal introgression on human complex traits. Elife. 2023 03 20; 12. Wei X, Robles CR, Pazokitoroudi A, Ganna A, Gusev A, Durvasula A, Gazal S, Loh PR, Reich D, Sankararaman S. PMID: 36939312; PMCID: PMC10076017.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    30. Phenotypic subtyping via contrastive learning. bioRxiv. 2023 Jan 06. Gorla A, Sankararaman S, Burchard E, Flint J, Zaitlen N, Rahmani E. PMID: 36711575; PMCID: PMC9881932.
      View in: PubMed   Mentions:
    31. Leveraging family data to design Mendelian Randomization that is provably robust to population stratification. bioRxiv. 2023 Jan 06. LaPierre N, Fu B, Turnbull S, Eskin E, Sankararaman S. PMID: 36711635; PMCID: PMC9881984.
      View in: PubMed   Mentions:
    32. MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations. Mol Biol Evol. 2023 01 04; 40(1). Zhang X, Kim B, Singh A, Sankararaman S, Durvasula A, Lohmueller KE. PMID: 36617238; PMCID: PMC9887621.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    33. Accurate modeling of replication rates in genome-wide association studies by accounting for Winner's Curse and study-specific heterogeneity. G3 (Bethesda). 2022 12 01; 12(12). Zou J, Zhou J, Faller S, Brown RP, Sankararaman SS, Eskin E. PMID: 36250793; PMCID: PMC9713380.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    34. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science. 2022 11 18; 378(6621):754-761. Border R, Athanasiadis G, Buil A, Schork AJ, Cai N, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA. PMID: 36395242; PMCID: PMC9901291.
      View in: PubMed   Mentions: 89     Fields:    Translation:Humans
    35. Author Correction: Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 2022 Nov 16; 14(1):128. Johnson R, Ding Y, Venkateswaran V, Bhattacharya A, Boulier K, Chiu A, Knyazev S, Schwarz T, Freund M, Zhan L, Burch KS, Caggiano C, Hill B, Rakocz N, Balliu B, Denny CT, Sul JH, Zaitlen N, Arboleda VA, Halperin E, Sankararaman S, Butte MJ, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working G, Lajonchere C, Geschwind DH, Pasaniuc B. PMID: 36384576; PMCID: PMC9670414.
      View in: PubMed   Mentions:    Fields:    
    36. Autonomous wearable sweat rate monitoring based on digitized microbubble detection. Lab Chip. 2022 11 08; 22(22):4267-4275. Lin H, Yu W, Suarez JED, Athavan H, Wang Y, Yeung C, Lin S, Sankararaman S, Milla C, Emaminejad S. PMID: 36268642; PMCID: PMC9757655.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative. Genome Med. 2022 Sep 09; 14(1):104. Johnson R, Ding Y, Venkateswaran V, Bhattacharya A, Boulier K, Chiu A, Knyazev S, Schwarz T, Freund M, Zhan L, Burch KS, Caggiano C, Hill B, Rakocz N, Balliu B, Denny CT, Sul JH, Zaitlen N, Arboleda VA, Halperin E, Sankararaman S, Butte MJ, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working G, Lajonchere C, Geschwind DH, Pasaniuc B. PMID: 36085083; PMCID: PMC9461263.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansPHPublic Health
    38. STENSL: Microbial Source Tracking with ENvironment SeLection. mSystems. 2022 10 26; 7(5):e0099521. An U, Shenhav L, Olson CA, Hsiao EY, Halperin E, Sankararaman S. PMID: 36047699; PMCID: PMC9599664.
      View in: PubMed   Mentions: 5     Fields:    
    39. Methylation risk scores are associated with a collection of phenotypes within electronic health record systems. NPJ Genom Med. 2022 Aug 25; 7(1):50. Thompson M, Hill BL, Rakocz N, Chiang JN, Geschwind D, Sankararaman S, Hofer I, Cannesson M, Zaitlen N, Halperin E. PMID: 36008412; PMCID: PMC9411568.
      View in: PubMed   Mentions: 35  
    40. Automated Identification of Incomplete and Complete Retinal Epithelial Pigment and Outer Retinal Atrophy Using Machine Learning. Ophthalmol Retina. 2023 02; 7(2):118-126. Chiang JN, Corradetti G, Nittala MG, Corvi F, Rakocz N, Rudas A, Durmus B, An U, Sankararaman S, Chiu A, Halperin E, Sadda SR. PMID: 35995411.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. Bruins-in-Genomics: Evaluation of the impact of a UCLA undergraduate summer program in computational biology on participating students. PLoS One. 2022; 17(5):e0268861. Coller HA, Beggs S, Andrews S, Maloy J, Chiu A, Sankararaman S, Pellegrini M, Freimer N, Johnson T, Papp J, Eskin E, Hoffmann A. PMID: 35622842; PMCID: PMC9140266.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. Inferring population structure in biobank-scale genomic data. Am J Hum Genet. 2022 04 07; 109(4):727-737. Chiu AM, Molloy EK, Tan Z, Talwalkar A, Sankararaman S. PMID: 35298920; PMCID: PMC9069078.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    43. Robust Mendelian randomization in the presence of residual population stratification, batch effects and horizontal pleiotropy. Nat Commun. 2022 03 01; 13(1):1093. Cinelli C, LaPierre N, Hill BL, Sankararaman S, Eskin E. PMID: 35232963; PMCID: PMC8888767.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    44. Evaluating supervised and unsupervised background noise correction in human gut microbiome data. PLoS Comput Biol. 2022 02; 18(2):e1009838. Briscoe L, Balliu B, Sankararaman S, Halperin E, Garud NR. PMID: 35130266; PMCID: PMC8853548.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    45. Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells. Mol Biol Evol. 2022 01 07; 39(1). Jagoda E, Xue JR, Reilly SK, Dannemann M, Racimo F, Huerta-Sanchez E, Sankararaman S, Kelso J, Pagani L, Sabeti PC, Capellini TD. PMID: 34662402; PMCID: PMC8760939.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    46. Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification. Nat Genet. 2022 01; 54(1):30-39. Ding Y, Hou K, Burch KS, Lapinska S, Privé F, Vilhjálmsson B, Sankararaman S, Pasaniuc B. PMID: 34931067; PMCID: PMC8758557.
      View in: PubMed   Mentions: 70     Fields:    Translation:Humans
    47. Fast estimation of genetic correlation for biobank-scale data. Am J Hum Genet. 2022 01 06; 109(1):24-32. Wu Y, Burch KS, Ganna A, Pajukanta P, Pasaniuc B, Sankararaman S. PMID: 34861179; PMCID: PMC8764132.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    48. Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits. PLoS Comput Biol. 2021 10; 17(10):e1009483. Johnson R, Burch KS, Hou K, Paciuc M, Pasaniuc B, Sankararaman S. PMID: 34673766; PMCID: PMC8562817.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    49. Advancing admixture graph estimation via maximum likelihood network orientation. Bioinformatics. 2021 07 12; 37(Suppl_1):i142-i150. Molloy EK, Durvasula A, Sankararaman S. PMID: 34252951; PMCID: PMC8336447.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    50. Marginal Contribution Feature Importance - an Axiomatic Approach for Explaining Data. Proc Mach Learn Res. 2021 Jul; 139:1324-1335. Catav A, Fu B, Zoabi Y, Weiss-Meilik A, Shomron N, Ernst J, Sankararaman S, Gilad-Bachrach R. PMID: 34568830; PMCID: PMC8460841.
      View in: PubMed   Mentions: 4  
    51. Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions. Elife. 2021 05 14; 10. Findley AS, Monziani A, Richards AL, Rhodes K, Ward MC, Kalita CA, Alazizi A, Pazokitoroudi A, Sankararaman S, Wen X, Lanfear DE, Pique-Regi R, Gilad Y, Luca F. PMID: 33988505; PMCID: PMC8248987.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    52. A two-step approach to testing overall effect of gene-environment interaction for multiple phenotypes. Bioinformatics. 2021 Apr 05; 36(24):5640-5648. Majumdar A, Burch KS, Haldar T, Sankararaman S, Pasaniuc B, Gauderman WJ, Witte JS. PMID: 33453114.
      View in: PubMed   Mentions: 7     Fields:    
    53. Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data. Am J Hum Genet. 2021 05 06; 108(5):799-808. Pazokitoroudi A, Chiu AM, Burch KS, Pasaniuc B, Sankararaman S. PMID: 33811807; PMCID: PMC8206203.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    54. Contra: Contrarian statistics for controlled variable selection. Proc Mach Learn Res. 2021 Apr; 130:1900-1908. Sudarshan M, Puli A, Subramanian L, Sankararaman S, Ranganath R. PMID: 34522887; PMCID: PMC8436172.
      View in: PubMed   Mentions: 1  
    55. Automated identification of clinical features from sparsely annotated 3-dimensional medical imaging. NPJ Digit Med. 2021 Mar 08; 4(1):44. Rakocz N, Chiang JN, Nittala MG, Corradetti G, Tiosano L, Velaga S, Thompson M, Hill BL, Sankararaman S, Haines JL, Pericak-Vance MA, Stambolian D, Sadda SR, Halperin E. PMID: 33686212; PMCID: PMC7940637.
      View in: PubMed   Mentions: 8  
    56. An efficient linear mixed model framework for meta-analytic association studies across multiple contexts. Algorithms Bioinform. 2021; 201. Jew B, Li J, Sankararaman S, Sul JH. PMID: 34335990; PMCID: PMC8323485.
      View in: PubMed   Mentions:
    57. Efficient variance components analysis across millions of genomes. Nat Commun. 2020 08 11; 11(1):4020. Pazokitoroudi A, Wu Y, Burch KS, Hou K, Zhou A, Pasaniuc B, Sankararaman S. PMID: 32782262; PMCID: PMC7419517.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    58. Methods for detecting introgressed archaic sequences. Curr Opin Genet Dev. 2020 06; 62:85-90. Sankararaman S. PMID: 32717667; PMCID: PMC7484293.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    59. Explaining Groups of Points in Low-Dimensional Representations. Proc Mach Learn Res. 2020 Jul; 119:7762-7771. Plumb G, Terhorst J, Sankararaman S, Talwalkar A. PMID: 34532709; PMCID: PMC8442997.
      View in: PubMed   Mentions: 2  
    60. Scalable probabilistic PCA for large-scale genetic variation data. PLoS Genet. 2020 05; 16(5):e1008773. Agrawal A, Chiu AM, Le M, Halperin E, Sankararaman S. PMID: 32469896; PMCID: PMC7286535.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    61. A Unifying Framework for Imputing Summary Statistics in Genome-Wide Association Studies. J Comput Biol. 2020 03; 27(3):418-428. Wu Y, Eskin E, Sankararaman S. PMID: 32053016; PMCID: PMC7081249.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    62. Recovering signals of ghost archaic introgression in African populations. Sci Adv. 2020 02; 6(7):eaax5097. Durvasula A, Sankararaman S. PMID: 32095519; PMCID: PMC7015685.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    63. An automated machine learning-based model predicts postoperative mortality using readily-extractable preoperative electronic health record data. Br J Anaesth. 2019 12; 123(6):877-886. Hill BL, Brown R, Gabel E, Rakocz N, Lee C, Cannesson M, Baldi P, Olde Loohuis L, Johnson R, Jew B, Maoz U, Mahajan A, Sankararaman S, Hofer I, Halperin E. PMID: 31627890; PMCID: PMC6883494.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    64. Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology. Nat Commun. 2019 07 31; 10(1):3417. Rahmani E, Schweiger R, Rhead B, Criswell LA, Barcellos LF, Eskin E, Rosset S, Sankararaman S, Halperin E. PMID: 31366909; PMCID: PMC6668473.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    65. Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture. Nat Genet. 2019 08; 51(8):1244-1251. Hou K, Burch KS, Majumdar A, Shi H, Mancuso N, Wu Y, Sankararaman S, Pasaniuc B. PMID: 31358995; PMCID: PMC6686906.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    66. A statistical model for reference-free inference of archaic local ancestry. PLoS Genet. 2019 05; 15(5):e1008175. Durvasula A, Sankararaman S. PMID: 31136573; PMCID: PMC6555542.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    67. A Comprehensive Map of Genetic Variation in the World's Largest Ethnic Group-Han Chinese. Mol Biol Evol. 2018 11 01; 35(11):2736-2750. Chiang CWK, Mangul S, Robles C, Sankararaman S. PMID: 30169787; PMCID: PMC6693441.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    68. A unifying framework for joint trait analysis under a non-infinitesimal model. Bioinformatics. 2018 07 01; 34(13):i195-i201. Johnson R, Shi H, Pasaniuc B, Sankararaman S. PMID: 29949958; PMCID: PMC6022541.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    69. A scalable estimator of SNP heritability for biobank-scale data. Bioinformatics. 2018 07 01; 34(13):i187-i194. Wu Y, Sankararaman S. PMID: 29950019; PMCID: PMC6022682.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    70. Natural selection interacts with recombination to shape the evolution of hybrid genomes. Science. 2018 May 11; 360(6389):656-660. Schumer M, Xu C, Powell DL, Durvasula A, Skov L, Holland C, Blazier JC, Sankararaman S, Andolfatto P, Rosenthal GG, Przeworski M. PMID: 29674434; PMCID: PMC6069607.
      View in: PubMed   Mentions: 190     Fields:    Translation:Animals
    71. Meiotic Genes Are Enriched in Regions of Reduced Archaic Ancestry. Mol Biol Evol. 2017 08 01; 34(8):1974-1980. Jégou B, Sankararaman S, Rolland AD, Reich D, Chalmel F. PMID: 28444387; PMCID: PMC5850719.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    72. Widespread Allelic Heterogeneity in Complex Traits. Am J Hum Genet. 2017 May 04; 100(5):789-802. Hormozdiari F, Zhu A, Kichaev G, Ju CJ, Segrè AV, Joo JWJ, Won H, Sankararaman S, Pasaniuc B, Shifman S, Eskin E. PMID: 28475861; PMCID: PMC5420356.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    73. Colocalization of GWAS and eQTL Signals Detects Target Genes. Am J Hum Genet. 2016 Dec 01; 99(6):1245-1260. Hormozdiari F, van de Bunt M, Segrè AV, Li X, Joo JWJ, Bilow M, Sul JH, Sankararaman S, Pasaniuc B, Eskin E. PMID: 27866706; PMCID: PMC5142122.
      View in: PubMed   Mentions: 419     Fields:    Translation:Humans
    74. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations. Nature. 2016 Oct 13; 538(7624):201-206. Mallick S, Li H, Lipson M, Mathieson I, Gymrek M, Racimo F, Zhao M, Chennagiri N, Nordenfelt S, Tandon A, Skoglund P, Lazaridis I, Sankararaman S, Fu Q, Rohland N, Renaud G, Erlich Y, Willems T, Gallo C, Spence JP, Song YS, Poletti G, Balloux F, van Driem G, de Knijff P, Romero IG, Jha AR, Behar DM, Bravi CM, Capelli C, Hervig T, Moreno-Estrada A, Posukh OL, Balanovska E, Balanovsky O, Karachanak-Yankova S, Sahakyan H, Toncheva D, Yepiskoposyan L, Tyler-Smith C, Xue Y, Abdullah MS, Ruiz-Linares A, Beall CM, Di Rienzo A, Jeong C, Starikovskaya EB, Metspalu E, Parik J, Villems R, Henn BM, Hodoglugil U, Mahley R, Sajantila A, Stamatoyannopoulos G, Wee JT, Khusainova R, Khusnutdinova E, Litvinov S, Ayodo G, Comas D, Hammer MF, Kivisild T, Klitz W, Winkler CA, Labuda D, Bamshad M, Jorde LB, Tishkoff SA, Watkins WS, Metspalu M, Dryomov S, Sukernik R, Singh L, Thangaraj K, Pääbo S, Kelso J, Patterson N, Reich D. PMID: 27654912; PMCID: PMC5161557.
      View in: PubMed   Mentions: 715     Fields:    Translation:HumansAnimals
    75. A genetic method for dating ancient genomes provides a direct estimate of human generation interval in the last 45,000 years. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5652-7. Moorjani P, Sankararaman S, Fu Q, Przeworski M, Patterson N, Reich D. PMID: 27140627; PMCID: PMC4878468.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    76. The Combined Landscape of Denisovan and Neanderthal Ancestry in Present-Day Humans. Curr Biol. 2016 05 09; 26(9):1241-7. Sankararaman S, Mallick S, Patterson N, Reich D. PMID: 27032491; PMCID: PMC4864120.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimals
    77. Calibrating the Human Mutation Rate via Ancestral Recombination Density in Diploid Genomes. PLoS Genet. 2015 Nov; 11(11):e1005550. Lipson M, Loh PR, Sankararaman S, Patterson N, Berger B, Reich D. PMID: 26562831; PMCID: PMC4642934.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    78. Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates. Am J Hum Genet. 2015 Dec 03; 97(6):775-89. Palamara PF, Francioli LC, Wilton PR, Genovese G, Gusev A, Finucane HK, Sankararaman S, Genome of the Netherlands Consortium, Sunyaev SR, de Bakker PI, Wakeley J, Pe'er I, Price AL. PMID: 26581902; PMCID: PMC4678427.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    79. Genetic and socioeconomic study of mate choice in Latinos reveals novel assortment patterns. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):13621-6. Zou JY, Park DS, Burchard EG, Torgerson DG, Pino-Yanes M, Song YS, Sankararaman S, Halperin E, Zaitlen N. PMID: 26483472; PMCID: PMC4640764.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    80. Inferring parental genomic ancestries using pooled semi-Markov processes. Bioinformatics. 2015 Jun 15; 31(12):i190-6. Zou JY, Halperin E, Burchard E, Sankararaman S. PMID: 26072482; PMCID: PMC4765873.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    81. Evidence for archaic adaptive introgression in humans. Nat Rev Genet. 2015 Jun; 16(6):359-71. Racimo F, Sankararaman S, Nielsen R, Huerta-Sánchez E. PMID: 25963373; PMCID: PMC4478293.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimals
    82. Leveraging population admixture to characterize the heritability of complex traits. Nat Genet. 2014 Dec; 46(12):1356-62. Zaitlen N, Pasaniuc B, Sankararaman S, Bhatia G, Zhang J, Gusev A, Young T, Tandon A, Pollack S, Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S, Franceschini N, Goodman PG, He J, Hennis AJ, Hsing A, Ingles SA, Isaacs W, Kittles RA, Klein EA, Lange LA, Nemesure B, Patterson N, Reich D, Rybicki BA, Stanford JL, Stevens VL, Strom SS, Whitsel EA, Witte JS, Xu J, Haiman C, Wilson JG, Kooperberg C, Stram D, Reiner AP, Tang H, Price AL. PMID: 25383972; PMCID: PMC4244251.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    83. The genomic landscape of Neanderthal ancestry in present-day humans. Nature. 2014 Mar 20; 507(7492):354-7. Sankararaman S, Mallick S, Dannemann M, Prüfer K, Kelso J, Pääbo S, Patterson N, Reich D. PMID: 24476815; PMCID: PMC4072735.
      View in: PubMed   Mentions: 398     Fields:    Translation:HumansAnimalsCells
    84. The complete genome sequence of a Neanderthal from the Altai Mountains. Nature. 2014 Jan 02; 505(7481):43-9. Prüfer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, Heinze A, Renaud G, Sudmant PH, de Filippo C, Li H, Mallick S, Dannemann M, Fu Q, Kircher M, Kuhlwilm M, Lachmann M, Meyer M, Ongyerth M, Siebauer M, Theunert C, Tandon A, Moorjani P, Pickrell J, Mullikin JC, Vohr SH, Green RE, Hellmann I, Johnson PL, Blanche H, Cann H, Kitzman JO, Shendure J, Eichler EE, Lein ES, Bakken TE, Golovanova LV, Doronichev VB, Shunkov MV, Derevianko AP, Viola B, Slatkin M, Reich D, Kelso J, Pääbo S. PMID: 24352235; PMCID: PMC4031459.
      View in: PubMed   Mentions: 821     Fields:    Translation:HumansAnimals
    85. Estimating and interpreting FST: the impact of rare variants. Genome Res. 2013 Sep; 23(9):1514-21. Bhatia G, Patterson N, Sankararaman S, Price AL. PMID: 23861382; PMCID: PMC3759727.
      View in: PubMed   Mentions: 290     Fields:    Translation:Humans
    86. Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation. Bioinformatics. 2013 Jun 01; 29(11):1407-15. Pasaniuc B, Sankararaman S, Torgerson DG, Gignoux C, Zaitlen N, Eng C, Rodriguez-Cintron W, Chapela R, Ford JG, Avila PC, Rodriguez-Santana J, Chen GK, Le Marchand L, Henderson B, Reich D, Haiman CA, Gonzàlez Burchard E, Halperin E. PMID: 23572411; PMCID: PMC3661056.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    87. The date of interbreeding between Neandertals and modern humans. PLoS Genet. 2012; 8(10):e1002947. Sankararaman S, Patterson N, Li H, Pääbo S, Reich D. PMID: 23055938; PMCID: PMC3464203.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimals
    88. Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nat Genet. 2012 Sep; 44(9):1015-9. Turchin MC, Chiang CW, Palmer CD, Sankararaman S, Reich D, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Hirschhorn JN. PMID: 22902787; PMCID: PMC3480734.
      View in: PubMed   Mentions: 162     Fields:    Translation:Humans
    89. Fast and accurate inference of local ancestry in Latino populations. Bioinformatics. 2012 May 15; 28(10):1359-67. Baran Y, Pasaniuc B, Sankararaman S, Torgerson DG, Gignoux C, Eng C, Rodriguez-Cintron W, Chapela R, Ford JG, Avila PC, Rodriguez-Santana J, Burchard EG, Halperin E. PMID: 22495753; PMCID: PMC3348558.
      View in: PubMed   Mentions: 161     Fields:    Translation:Humans
    90. Phylogenetic inference via sequential Monte Carlo. Syst Biol. 2012 Jul; 61(4):579-93. Bouchard-Côté A, Sankararaman S, Jordan MI. PMID: 22223445; PMCID: PMC3376373.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    91. Genome-wide association identifies candidate genes that influence the human electroencephalogram. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8695-700. Hodgkinson CA, Enoch MA, Srivastava V, Cummins-Oman JS, Ferrier C, Iarikova P, Sankararaman S, Yamini G, Yuan Q, Zhou Z, Albaugh B, White KV, Shen PH, Goldman D. PMID: 20421487; PMCID: PMC2889314.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    92. Active site prediction using evolutionary and structural information. Bioinformatics. 2010 Mar 01; 26(5):617-24. Sankararaman S, Sha F, Kirsch JF, Jordan MI, Sjölander K. PMID: 20080507; PMCID: PMC2828116.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    93. Genomic privacy and limits of individual detection in a pool. Nat Genet. 2009 Sep; 41(9):965-7. Sankararaman S, Obozinski G, Jordan MI, Halperin E. PMID: 19701190.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    94. ResBoost: characterizing and predicting catalytic residues in enzymes. BMC Bioinformatics. 2009 Jun 27; 10:197. Alterovitz R, Arvey A, Sankararaman S, Dallett C, Freund Y, Sjölander K. PMID: 19558703; PMCID: PMC2713229.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    95. Inference of locus-specific ancestry in closely related populations. Bioinformatics. 2009 Jun 15; 25(12):i213-21. Pasaniuc B, Sankararaman S, Kimmel G, Halperin E. PMID: 19477991; PMCID: PMC2687951.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    96. INTREPID: a web server for prediction of functionally important residues by evolutionary analysis. Nucleic Acids Res. 2009 Jul; 37(Web Server issue):W390-5. Sankararaman S, Kolaczkowski B, Sjölander K. PMID: 19443452; PMCID: PMC2703888.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    97. INTREPID--INformation-theoretic TREe traversal for Protein functional site IDentification. Bioinformatics. 2008 Nov 01; 24(21):2445-52. Sankararaman S, Sjölander K. PMID: 18776193; PMCID: PMC2572704.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    98. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. PLoS One. 2008 Jun 30; 3(7):e2816. Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT. PMID: 18636124; PMCID: PMC2474696.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    99. On the inference of ancestries in admixed populations. Genome Res. 2008 Apr; 18(4):668-75. Sankararaman S, Kimmel G, Halperin E, Jordan MI. PMID: 18353809; PMCID: PMC2279254.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    100. Estimating local ancestry in admixed populations. Am J Hum Genet. 2008 Feb; 82(2):290-303. Sankararaman S, Sridhar S, Kimmel G, Halperin E. PMID: 18252211; PMCID: PMC2664993.
      View in: PubMed   Mentions: 214     Fields:    Translation:Humans
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