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Kirk Edward Lohmueller

Title(s)Professor, Ecology And Evolutionary Biology
SchoolCollege of Letters and Science
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    Other Positions
    Title(s)Professor, Human Genetics


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    QUANTIFYING THE IMPACT OF CIRCADIAN DISRUPTION ON GENOME STABILITY
    NIH R21ES031000Aug 15, 2019 - Jul 31, 2021
    Role: Co-Principal Investigator
    Population genomics of the selective effects of new mutations
    NIH R35GM119856Sep 1, 2016 - May 31, 2026
    Role: Principal Investigator
    Population genetics of deleterious polymorphism in human populations
    NIH F32HG005308Jan 1, 2010 - Jun 30, 2010
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inference of population demographic history captures differing evolutionary signals based on the number of individuals in the dataset. bioRxiv. 2026 Apr 08. Mah JC, Lohmueller KE. PMID: 41993374; PMCID: PMC13081979.
      View in: PubMed   Mentions:
    2. The impact of non-neutral synonymous mutations when inferring selection on nonsynonymous mutations. Genetics. 2025 Dec 10; 231(4). Martinez I Zurita A, Kyriazis CC, Lohmueller KE. PMID: 41014119; PMCID: PMC12693584.
      View in: PubMed   Mentions:    Fields:    
    3. Genome-wide selection inference at short tandem repeats. PLoS Genet. 2025 Dec; 21(12):e1011959. Huang B, Durvasula A, Mousavi N, Ziaei-Jam H, Maksimov M, Lohmueller KE, Gymrek M. PMID: 41325473; PMCID: PMC12680348.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Accessible, Realistic Genome Simulation with Selection Using stdpopsim. Mol Biol Evol. 2025 Oct 29; 42(11). Gower G, Pope NS, Rodrigues MF, Tittes S, Tran LN, Alam O, Cavassim MIA, Fields PD, Haller BC, Huang X, Jeffrey B, Korfmann K, Kyriazis CC, Min J, Rebollo I, Rehmann CT, Small ST, Smith CCR, Tsambos G, Wong Y, Zhang Y, Huber CD, Gorjanc G, Ragsdale AP, Gronau I, Gutenkunst RN, Kelleher J, Lohmueller KE, Schrider DR, Ralph PL, Kern AD. PMID: 40994024; PMCID: PMC12574676.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Accessible, realistic genome simulation with selection using stdpopsim. bioRxiv. 2025 Aug 12. Gower G, Pope NS, Rodrigues MF, Tittes S, Tran LN, Alam O, Cavassim MIA, Fields PD, Haller BC, Huang X, Jeffrey B, Korfmann K, Kyriazis CC, Min J, Rebollo I, Rehmann CT, Small ST, Smith CCR, Tsambos G, Wong Y, Zhang Y, Huber CD, Gorjanc G, Ragsdale AP, Gronau I, Gutenkunst RN, Kelleher J, Lohmueller KE, Schrider DR, Ralph PL, Kern AD. PMID: 40166307; PMCID: PMC11957135.
      View in: PubMed   Mentions:
    6. Long runs of homozygosity are reliable genomic markers of inbreeding depression. Trends Ecol Evol. 2025 Sep; 40(9):874-884. Kyriazis CC, Robinson JA, Lohmueller KE. PMID: 40752972.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    7. Genetic rescue of Florida panthers reduced homozygosity but did not swamp ancestral genotypes. Proc Natl Acad Sci U S A. 2025 Aug 05; 122(31):e2410945122. Aguilar-Gómez D, Yuan L, Zhang Y, Ochoa A, Culver M, Fitak RR, Onorato D, Lohmueller KE, Nielsen R. PMID: 40720660; PMCID: PMC12337334.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    8. The landscape of fitness effects of putatively functional noncoding mutations in humans. bioRxiv. 2025 May 14. Di C, Ramesh S, Ernst J, Lohmueller KE. PMID: 40463122; PMCID: PMC12132340.
      View in: PubMed   Mentions:
    9. The distribution of fitness effects varies phylogenetically across animals. bioRxiv. 2025 May 13. Lin M, Chakraborty S, Amorim CEG, Nigenda-Morales SF, Beichman AC, Nuñez-Valencia PG, Mah J, Robinson JA, Kyriazis CC, Huber CD, Webb AE, Kocher SD, Archer FI, Moreno-Estrada A, Wayne RK, Lohmueller KE. PMID: 40463062; PMCID: PMC12132501.
      View in: PubMed   Mentions:
    10. Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations. bioRxiv. 2025 May 07. Zhang X, Yang J, Zhu L, Sachdev N, Mooney J, Sankararaman S, Lohmueller KE. PMID: 40654668; PMCID: PMC12248111.
      View in: PubMed   Mentions:
    11. Inference of the Demographic Histories and Selective Effects of Human Gut Commensal Microbiota Over the Course of Human History. Mol Biol Evol. 2025 Feb 03; 42(2). Mah JC, Lohmueller KE, Garud NR. PMID: 39838923; PMCID: PMC11824422.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    12. Evolutionary consequences of domestication on the selective effects of new amino acid changing mutations in canids. bioRxiv. 2024 Nov 14. Amorim CEG, Di C, Lin M, Marsden C, Del Carpio CA, Mah JC, Robinson J, Kim BY, Mooney JA, Cornejo OE, Lohmueller KE. PMID: 39605619; PMCID: PMC11601280.
      View in: PubMed   Mentions:
    13. Constraining models of dominance for nonsynonymous mutations in the human genome. PLoS Genet. 2024 Sep; 20(9):e1011198. Kyriazis CC, Lohmueller KE. PMID: 39302992; PMCID: PMC11446423.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Revisiting Dominance in Population Genetics. Genome Biol Evol. 2024 Aug 05; 16(8). Di C, Lohmueller KE. PMID: 39114967; PMCID: PMC11306932.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    15. The influence of gene flow on population viability in an isolated urban caracal population. Mol Ecol. 2024 May; 33(9):e17346. Kyriazis CC, Serieys LEK, Bishop JM, Drouilly M, Viljoen S, Wayne RK, Lohmueller KE. PMID: 38581173; PMCID: PMC11035096.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations. Bioinformatics. 2024 03 29; 40(4). Hou K, Gogarten S, Kim J, Hua X, Dias JA, Sun Q, Wang Y, Tan T, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group, Atkinson EG, Martin A, Shortt J, Hirbo J, Li Y, Pasaniuc B, Zhang H. PMID: 38490256; PMCID: PMC10980565.
      View in: PubMed   Mentions: 11     Fields:    
    17. Constraining models of dominance for nonsynonymous mutations in the human genome. bioRxiv. 2024 Feb 26. Kyriazis CC, Lohmueller KE. PMID: 38463985; PMCID: PMC10925099.
      View in: PubMed   Mentions:
    18. The impact of non-neutral synonymous mutations when inferring selection on non-synonymous mutations. bioRxiv. 2024 Feb 08. Zurita AMI, Kyriazis CC, Lohmueller KE. PMID: 38370782; PMCID: PMC10871344.
      View in: PubMed   Mentions:
    19. Inference of the demographic histories and selective effects of human gut commensal microbiota over the course of human history. bioRxiv. 2023 Nov 13. Mah JC, Lohmueller KE, Garud N. PMID: 38014007; PMCID: PMC10680615.
      View in: PubMed   Mentions:
    20. Using Computational Simulations to Model Deleterious Variation and Genetic Load in Natural Populations. Am Nat. 2023 12; 202(6):737-752. Kyriazis CC, Robinson JA, Lohmueller KE. PMID: 38033186; PMCID: PMC10897732.
      View in: PubMed   Mentions: 19     Fields:    
    21. The genomic footprint of whaling and isolation in fin whale populations. Nat Commun. 2023 09 12; 14(1):5465. Nigenda-Morales SF, Lin M, Nuñez-Valencia PG, Kyriazis CC, Beichman AC, Robinson JA, Ragsdale AP, Urbán R J, Archer FI, Viloria-Gómora L, Pérez-Álvarez MJ, Poulin E, Lohmueller KE, Moreno-Estrada A, Wayne RK. PMID: 37699896; PMCID: PMC10497599.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    22. Quantifying the fraction of new mutations that are recessive lethal. Evolution. 2023 06 29; 77(7):1539-1549. Wade EE, Kyriazis CC, Cavassim MIA, Lohmueller KE. PMID: 37074880; PMCID: PMC10309970.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    23. Inferring the mode and strength of ongoing selection. Genome Res. 2023 04; 33(4):632-643. Barroso GV, Lohmueller KE. PMID: 37055196; PMCID: PMC10234300.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. Remembering distinguished professor Robert K. Wayne. Mol Ecol. 2023 05; 32(9):2364-2368. Leonard JA, von Holdt B, Smith TB, Sork VL, Shapiro B, Ostrander EA, Rieseberg LH, Van Valkenburgh B, Lohmueller KE. PMID: 36991555.
      View in: PubMed   Mentions:    Fields:    
    25. Models based on best-available information support a low inbreeding load and potential for recovery in the vaquita. Heredity (Edinb). 2023 04; 130(4):183-187. Kyriazis CC, Robinson JA, Nigenda-Morales SF, Beichman AC, Rojas-Bracho L, Robertson KM, Fontaine MC, Wayne RK, Taylor BL, Lohmueller KE, Morin PA. PMID: 36941409; PMCID: PMC10076335.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    26. Genomic Underpinnings of Population Persistence in Isle Royale Moose. Mol Biol Evol. 2023 02 03; 40(2). Kyriazis CC, Beichman AC, Brzeski KE, Hoy SR, Peterson RO, Vucetich JA, Vucetich LM, Lohmueller KE, Wayne RK. PMID: 36729989; PMCID: PMC9927576.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    27. MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations. Mol Biol Evol. 2023 01 04; 40(1). Zhang X, Kim B, Singh A, Sankararaman S, Durvasula A, Lohmueller KE. PMID: 36617238; PMCID: PMC9887621.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    28. Long-term Small Population Size, Deleterious Variation, and Altitude Adaptation in the Ethiopian Wolf, a Severely Endangered Canid. Mol Biol Evol. 2023 01 04; 40(1). Mooney JA, Marsden CD, Yohannes A, Wayne RK, Lohmueller KE. PMID: 36585842; PMCID: PMC9847632.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    29. Deleterious Variation in Natural Populations and Implications for Conservation Genetics. Annu Rev Anim Biosci. 2023 02 15; 11:93-114. Robinson J, Kyriazis CC, Yuan SC, Lohmueller KE. PMID: 36332644; PMCID: PMC9933137.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    30. On the prospect of achieving accurate joint estimation of selection with population history. Genome Biol Evol. 2022 07 02; 14(7). Johri P, Eyre-Walker A, Gutenkunst RN, Lohmueller KE, Jensen JD. PMID: 35675379; PMCID: PMC9254643.
      View in: PubMed   Mentions: 38     Fields:    
    31. The critically endangered vaquita is not doomed to extinction by inbreeding depression. Science. 2022 05 06; 376(6593):635-639. Robinson JA, Kyriazis CC, Nigenda-Morales SF, Beichman AC, Rojas-Bracho L, Robertson KM, Fontaine MC, Wayne RK, Lohmueller KE, Taylor BL, Morin PA. PMID: 35511971; PMCID: PMC9881057.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    32. High-quality genome and methylomes illustrate features underlying evolutionary success of oaks. Nat Commun. 2022 04 19; 13(1):2047. Sork VL, Cokus SJ, Fitz-Gibbon ST, Zimin AV, Puiu D, Garcia JA, Gugger PF, Henriquez CL, Zhen Y, Lohmueller KE, Pellegrini M, Salzberg SL. PMID: 35440538; PMCID: PMC9018854.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    33. Haplotype-based inference of the distribution of fitness effects. Genetics. 2022 04 04; 220(4). Ortega-Del Vecchyo D, Lohmueller KE, Novembre J. PMID: 35100400; PMCID: PMC8982047.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. Genomic analyses reveal range-wide devastation of sea otter populations. Mol Ecol. 2023 01; 32(2):281-298. Beichman AC, Kalhori P, Kyriazis CC, DeVries AA, Nigenda-Morales S, Heckel G, Schramm Y, Moreno-Estrada A, Kennett DJ, Hylkema M, Bodkin J, Koepfli KP, Lohmueller KE, Wayne RK. PMID: 34967471; PMCID: PMC9875727.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    35. A signature of Neanderthal introgression on molecular mechanisms of environmental responses. PLoS Genet. 2021 09; 17(9):e1009493. Findley AS, Zhang X, Boye C, Lin YL, Kalita CA, Barreiro L, Lohmueller KE, Pique-Regi R, Luca F. PMID: 34570765; PMCID: PMC8509894.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    36. Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome. PLoS Genet. 2021 07; 17(7):e1009676. Garcia JA, Lohmueller KE. PMID: 34319975; PMCID: PMC8351996.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    37. The impact of identity by descent on fitness and disease in dogs. Proc Natl Acad Sci U S A. 2021 04 20; 118(16). Mooney JA, Yohannes A, Lohmueller KE. PMID: 33853941; PMCID: PMC8072400.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    38. Negative selection on complex traits limits phenotype prediction accuracy between populations. Am J Hum Genet. 2021 04 01; 108(4):620-631. Durvasula A, Lohmueller KE. PMID: 33691092; PMCID: PMC8059340.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    39. Patterns of de novo tandem repeat mutations and their role in autism. Nature. 2021 01; 589(7841):246-250. Mitra I, Huang B, Mousavi N, Ma N, Lamkin M, Yanicky R, Shleizer-Burko S, Lohmueller KE, Gymrek M. PMID: 33442040; PMCID: PMC7810352.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    40. Strongly deleterious mutations are a primary determinant of extinction risk due to inbreeding depression. Evol Lett. 2021 Feb; 5(1):33-47. Kyriazis CC, Wayne RK, Lohmueller KE. PMID: 33552534; PMCID: PMC7857301.
      View in: PubMed   Mentions: 111  
    41. Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations. Nat Commun. 2020 12 02; 11(1):6168. Grujic O, Phung TN, Kwon SB, Arneson A, Lee Y, Lohmueller KE, Ernst J. PMID: 33268804; PMCID: PMC7710766.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    42. Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice and Drosophila melanogaster. Genome Res. 2021 01; 31(1):110-120. Zhen Y, Huber CD, Davies RW, Lohmueller KE. PMID: 33208456; PMCID: PMC7849390.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    43. A community-maintained standard library of population genetic models. Elife. 2020 06 23; 9. Adrion JR, Cole CB, Dukler N, Galloway JG, Gladstein AL, Gower G, Kyriazis CC, Ragsdale AP, Tsambos G, Baumdicker F, Carlson J, Cartwright RA, Durvasula A, Gronau I, Kim BY, McKenzie P, Messer PW, Noskova E, Ortega-Del Vecchyo D, Racimo F, Struck TJ, Gravel S, Gutenkunst RN, Lohmueller KE, Ralph PL, Schrider DR, Siepel A, Kelleher J, Kern AD. PMID: 32573438; PMCID: PMC7438115.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    44. The Impact of Recessive Deleterious Variation on Signals of Adaptive Introgression in Human Populations. Genetics. 2020 07; 215(3):799-812. Zhang X, Kim B, Lohmueller KE, Huerta-Sánchez E. PMID: 32487519; PMCID: PMC7337073.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    45. Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution. PLoS Genet. 2020 05; 16(5):e1008827. Huber CD, Kim BY, Lohmueller KE. PMID: 32469868; PMCID: PMC7286533.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    46. Aquatic Adaptation and Depleted Diversity: A Deep Dive into the Genomes of the Sea Otter and Giant Otter. Mol Biol Evol. 2019 12 01; 36(12):2631-2655. Beichman AC, Koepfli KP, Li G, Murphy W, Dobrynin P, Kliver S, Tinker MT, Murray MJ, Johnson J, Lindblad-Toh K, Karlsson EK, Lohmueller KE, Wayne RK. PMID: 31212313; PMCID: PMC7967881.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    47. Testing whether stutter and low-level DNA peaks are additive. Forensic Sci Int Genet. 2019 11; 43:102166. Buckleton JS, Lohmueller KE, Inman K, Cheng K, Curran JM, Pugh SN, Bright JA, Taylor DA. PMID: 31586815.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    48. Ten simple rules for giving an effective academic job talk. PLoS Comput Biol. 2019 07; 15(7):e1007163. Sura SA, Smith LL, Ambrose MR, Amorim CEG, Beichman AC, Gomez ACR, Juhn M, Kandlikar GS, Miller JS, Mooney J, Mummah RO, Lohmueller KE, Lloyd-Smith JO. PMID: 31344032; PMCID: PMC6657819.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    49. Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. Sci Adv. 2019 05; 5(5):eaau0757. Robinson JA, Räikkönen J, Vucetich LM, Vucetich JA, Peterson RO, Lohmueller KE, Wayne RK. PMID: 31149628; PMCID: PMC6541468.
      View in: PubMed   Mentions: 127     Fields:    Translation:Animals
    50. Complex patterns of sex-biased demography in canines. Proc Biol Sci. 2019 05 29; 286(1903):20181976. Phung TN, Wayne RK, Wilson MA, Lohmueller KE. PMID: 31113325; PMCID: PMC6545087.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    51. Growth factor gene IGF1 is associated with bill size in the black-bellied seedcracker Pyrenestes ostrinus. Nat Commun. 2018 11 19; 9(1):4855. vonHoldt BM, Kartzinel RY, Huber CD, Le Underwood V, Zhen Y, Ruegg K, Lohmueller KE, Smith TB. PMID: 30451848; PMCID: PMC6242981.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    52. Purging of Strongly Deleterious Mutations Explains Long-Term Persistence and Absence of Inbreeding Depression in Island Foxes. Curr Biol. 2018 11 05; 28(21):3487-3494.e4. Robinson JA, Brown C, Kim BY, Lohmueller KE, Wayne RK. PMID: 30415705; PMCID: PMC6462144.
      View in: PubMed   Mentions: 101     Fields:    Translation:Animals
    53. Understanding the Hidden Complexity of Latin American Population Isolates. Am J Hum Genet. 2018 11 01; 103(5):707-726. Mooney JA, Huber CD, Service S, Sul JH, Marsden CD, Zhang Z, Sabatti C, Ruiz-Linares A, Bedoya G, Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar Endophenotypes, Freimer N, Lohmueller KE. PMID: 30401458; PMCID: PMC6218714.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    54. Deleterious variation shapes the genomic landscape of introgression. PLoS Genet. 2018 10; 14(10):e1007741. Kim BY, Huber CD, Lohmueller KE. PMID: 30346959; PMCID: PMC6233928.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    55. RADseq data reveal ancient, but not pervasive, introgression between Californian tree and scrub oak species (Quercus sect. Quercus: Fagaceae). Mol Ecol. 2018 11; 27(22):4556-4571. Kim BY, Wei X, Fitz-Gibbon S, Lohmueller KE, Ortego J, Gugger PF, Sork VL. PMID: 30226013.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    56. Genomic history of the Sardinian population. Nat Genet. 2018 10; 50(10):1426-1434. Chiang CWK, Marcus JH, Sidore C, Biddanda A, Al-Asadi H, Zoledziewska M, Pitzalis M, Busonero F, Maschio A, Pistis G, Steri M, Angius A, Lohmueller KE, Abecasis GR, Schlessinger D, Cucca F, Novembre J. PMID: 30224645; PMCID: PMC6168346.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    57. Gene expression drives the evolution of dominance. Nat Commun. 2018 07 16; 9(1):2750. Huber CD, Durvasula A, Hancock AM, Lohmueller KE. PMID: 30013096; PMCID: PMC6048131.
      View in: PubMed   Mentions: 63     Fields:    Translation:Animals
    58. Natural Selection and Origin of a Melanistic Allele in North American Gray Wolves. Mol Biol Evol. 2018 05 01; 35(5):1190-1209. Schweizer RM, Durvasula A, Smith J, Vohr SH, Stahler DR, Galaverni M, Thalmann O, Smith DW, Randi E, Ostrander EA, Green RE, Lohmueller KE, Novembre J, Wayne RK. PMID: 29688543; PMCID: PMC6455901.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    59. Comparison of Single Genome and Allele Frequency Data Reveals Discordant Demographic Histories. G3 (Bethesda). 2017 11 06; 7(11):3605-3620. Beichman AC, Phung TN, Lohmueller KE. PMID: 28893846; PMCID: PMC5677151.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    60. Genomic divergence across ecological gradients in the Central African rainforest songbird (Andropadus virens). Mol Ecol. 2017 Oct; 26(19):4966-4977. Zhen Y, Harrigan RJ, Ruegg KC, Anderson EC, Ng TC, Lao S, Lohmueller KE, Smith TB. PMID: 28752944.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    61. Determining the factors driving selective effects of new nonsynonymous mutations. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4465-4470. Huber CD, Kim BY, Marsden CD, Lohmueller KE. PMID: 28400513; PMCID: PMC5410820.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    62. Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples. Genetics. 2017 05; 206(1):345-361. Kim BY, Huber CD, Lohmueller KE. PMID: 28249985; PMCID: PMC5419480.
      View in: PubMed   Mentions: 141     Fields:    Translation:Humans
    63. The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit. Genetics. 2017 02; 205(2):787-801. Pedersen CT, Lohmueller KE, Grarup N, Bjerregaard P, Hansen T, Siegismund HR, Moltke I, Albrechtsen A. PMID: 27903613; PMCID: PMC5289852.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    64. Determining the Effect of Natural Selection on Linked Neutral Divergence across Species. PLoS Genet. 2016 08; 12(8):e1006199. Phung TN, Huber CD, Lohmueller KE. PMID: 27508305; PMCID: PMC4980041.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    65. PReFerSim: fast simulation of demography and selection under the Poisson Random Field model. Bioinformatics. 2016 11 15; 32(22):3516-3518. Ortega-Del Vecchyo D, Marsden CD, Lohmueller KE. PMID: 27436562; PMCID: PMC5181561.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    66. Genomic Flatlining in the Endangered Island Fox. Curr Biol. 2016 05 09; 26(9):1183-9. Robinson JA, Ortega-Del Vecchyo D, Fan Z, Kim BY, vonHoldt BM, Marsden CD, Lohmueller KE, Wayne RK. PMID: 27112291.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    67. An assessment of the information content of likelihood ratios derived from complex mixtures. Forensic Sci Int Genet. 2016 May; 22:64-72. Marsden CD, Rudin N, Inman K, Lohmueller KE. PMID: 26851613.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    68. Validation of probabilistic genotyping software for use in forensic DNA casework: Definitions and illustrations. Sci Justice. 2016 Mar; 56(2):104-8. Haned H, Gill P, Lohmueller K, Inman K, Rudin N. PMID: 26976468.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    69. Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs. Proc Natl Acad Sci U S A. 2016 01 05; 113(1):152-7. Marsden CD, Ortega-Del Vecchyo D, O'Brien DP, Taylor JF, Ramirez O, Vilà C, Marques-Bonet T, Schnabel RD, Wayne RK, Lohmueller KE. PMID: 26699508; PMCID: PMC4711855.
      View in: PubMed   Mentions: 191     Fields:    Translation:Animals
    70. Lab Retriever: a software tool for calculating likelihood ratios incorporating a probability of drop-out for forensic DNA profiles. BMC Bioinformatics. 2015 09 18; 16:298. Inman K, Rudin N, Cheng K, Robinson C, Kirschner A, Inman-Semerau L, Lohmueller KE. PMID: 26384762; PMCID: PMC4575494.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    71. Height-reducing variants and selection for short stature in Sardinia. Nat Genet. 2015 Nov; 47(11):1352-1356. Zoledziewska M, Sidore C, Chiang CWK, Sanna S, Mulas A, Steri M, Busonero F, Marcus JH, Marongiu M, Maschio A, Ortega Del Vecchyo D, Floris M, Meloni A, Delitala A, Concas MP, Murgia F, Biino G, Vaccargiu S, Nagaraja R, Lohmueller KE, UK10K consortium, Timpson NJ, Soranzo N, Tachmazidou I, Dedoussis G, Zeggini E, Understanding Society Scientific Group, Uzzau S, Jones C, Lyons R, Angius A, Abecasis GR, Novembre J, Schlessinger D, Cucca F. PMID: 26366551; PMCID: PMC4627578.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    72. Fitting the Balding-Nichols model to forensic databases. Forensic Sci Int Genet. 2015 Nov; 19:86-91. Rohlfs RV, Aguiar VRC, Lohmueller KE, Castro AM, Ferreira ACS, Almeida VCO, Louro ID, Nielsen R. PMID: 26186694.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    73. Leveraging ancestry to improve causal variant identification in exome sequencing for monogenic disorders. Eur J Hum Genet. 2016 Jan; 24(1):113-9. Brown R, Lee H, Eskin A, Kichaev G, Lohmueller KE, Reversade B, Nelson SF, Pasaniuc B. PMID: 25898925; PMCID: PMC4795218.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    74. Selection and reduced population size cannot explain higher amounts of Neandertal ancestry in East Asian than in European human populations. Am J Hum Genet. 2015 Mar 05; 96(3):454-61. Kim BY, Lohmueller KE. PMID: 25683122; PMCID: PMC4375557.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    75. The distribution of deleterious genetic variation in human populations. Curr Opin Genet Dev. 2014 Dec; 29:139-46. Lohmueller KE. PMID: 25461617.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    76. Evolution. On the origin of Peter Rabbit. Science. 2014 Aug 29; 345(6200):1000-1. Lohmueller KE. PMID: 25170135.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    77. A model-based approach for identifying signatures of ancient balancing selection in genetic data. PLoS Genet. 2014 Aug; 10(8):e1004561. DeGiorgio M, Lohmueller KE, Nielsen R. PMID: 25144706; PMCID: PMC4140648.
      View in: PubMed   Mentions: 91     Fields:    Translation:Humans
    78. Amerindian-specific regions under positive selection harbour new lipid variants in Latinos. Nat Commun. 2014 Jun 02; 5:3983. Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PM, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC, Arellano-Campos O, Muñoz-Hernández LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliövaara M, Raitakari O, Lehtimäki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen MR, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P. PMID: 24886709; PMCID: PMC4062071.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    79. The impact of population demography and selection on the genetic architecture of complex traits. PLoS Genet. 2014; 10(5):e1004379. Lohmueller KE. PMID: 24875776; PMCID: PMC4038606.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    80. Analysis of allelic drop-out using the Identifiler(®) and PowerPlex(®) 16 forensic STR typing systems. Forensic Sci Int Genet. 2014 Sep; 12:1-11. Lohmueller KE, Rudin N, Inman K. PMID: 24841801.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    81. Natural selection reduced diversity on human y chromosomes. PLoS Genet. 2014 Jan; 10(1):e1004064. Wilson Sayres MA, Lohmueller KE, Nielsen R. PMID: 24415951; PMCID: PMC3886894.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    82. Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am J Hum Genet. 2013 Dec 05; 93(6):1072-86. Lohmueller KE, Sparsø T, Li Q, Andersson E, Korneliussen T, Albrechtsen A, Banasik K, Grarup N, Hallgrimsdottir I, Kiil K, Kilpeläinen TO, Krarup NT, Pers TH, Sanchez G, Hu Y, Degiorgio M, Jørgensen T, Sandbæk A, Lauritzen T, Brunak S, Kristiansen K, Li Y, Hansen T, Wang J, Nielsen R, Pedersen O. PMID: 24290377; PMCID: PMC3852935.
      View in: PubMed   Mentions: 78     Fields:    Translation:Humans
    83. Calculating the weight of evidence in low-template forensic DNA casework. J Forensic Sci. 2013 Jan; 58 Suppl 1:S243-9. Lohmueller KE, Rudin N. PMID: 23082963; PMCID: PMC6449098.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    84. Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome. PLoS Genet. 2011 Oct; 7(10):e1002326. Lohmueller KE, Albrechtsen A, Li Y, Kim SY, Korneliussen T, Vinckenbosch N, Tian G, Huerta-Sanchez E, Feder AF, Grarup N, Jørgensen T, Jiang T, Witte DR, Sandbæk A, Hellmann I, Lauritzen T, Hansen T, Pedersen O, Wang J, Nielsen R. PMID: 22022285; PMCID: PMC3192825.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    85. An Aboriginal Australian genome reveals separate human dispersals into Asia. Science. 2011 Oct 07; 334(6052):94-8. Rasmussen M, Guo X, Wang Y, Lohmueller KE, Rasmussen S, Albrechtsen A, Skotte L, Lindgreen S, Metspalu M, Jombart T, Kivisild T, Zhai W, Eriksson A, Manica A, Orlando L, De La Vega FM, Tridico S, Metspalu E, Nielsen K, Ávila-Arcos MC, Moreno-Mayar JV, Muller C, Dortch J, Gilbert MT, Lund O, Wesolowska A, Karmin M, Weinert LA, Wang B, Li J, Tai S, Xiao F, Hanihara T, van Driem G, Jha AR, Ricaut FX, de Knijff P, Migliano AB, Gallego Romero I, Kristiansen K, Lambert DM, Brunak S, Forster P, Brinkmann B, Nehlich O, Bunce M, Richards M, Gupta R, Bustamante CD, Krogh A, Foley RA, Lahr MM, Balloux F, Sicheritz-Pontén T, Villems R, Nielsen R, Wang J, Willerslev E. PMID: 21940856; PMCID: PMC3991479.
      View in: PubMed   Mentions: 263     Fields:    Translation:HumansAnimals
    86. Estimation of allele frequency and association mapping using next-generation sequencing data. BMC Bioinformatics. 2011 Jun 11; 12:231. Kim SY, Lohmueller KE, Albrechtsen A, Li Y, Korneliussen T, Tian G, Grarup N, Jiang T, Andersen G, Witte D, Jorgensen T, Hansen T, Pedersen O, Wang J, Nielsen R. PMID: 21663684; PMCID: PMC3212839.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    87. Detecting directional selection in the presence of recent admixture in African-Americans. Genetics. 2011 Mar; 187(3):823-35. Lohmueller KE, Bustamante CD, Clark AG. PMID: 21196524; PMCID: PMC3063676.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    88. A simple genetic architecture underlies morphological variation in dogs. PLoS Biol. 2010 Aug 10; 8(8):e1000451. Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A, Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD, Ostrander EA. PMID: 20711490; PMCID: PMC2919785.
      View in: PubMed   Mentions: 273     Fields:    Translation:Animals
    89. Sex-averaged recombination and mutation rates on the X chromosome: a comment on Labuda et al. Am J Hum Genet. 2010 Jun 11; 86(6):978-80; author reply 980-1. Lohmueller KE, Degenhardt JD, Keinan A. PMID: 20541048; PMCID: PMC3032063.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    90. The effect of recent admixture on inference of ancient human population history. Genetics. 2010 Jun; 185(2):611-22. Lohmueller KE, Bustamante CD, Clark AG. PMID: 20382834; PMCID: PMC2881141.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    91. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature. 2010 Apr 08; 464(7290):898-902. Vonholdt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK. PMID: 20237475; PMCID: PMC3494089.
      View in: PubMed   Mentions: 325     Fields:    Translation:Animals
    92. Graydon et al. provide no new evidence that forensic STR loci are functional. Forensic Sci Int Genet. 2010 Jul; 4(4):273-4. Lohmueller KE. PMID: 20457048.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    93. Detecting ancient admixture and estimating demographic parameters in multiple human populations. Mol Biol Evol. 2009 Aug; 26(8):1823-7. Wall JD, Lohmueller KE, Plagnol V. PMID: 19420049; PMCID: PMC2734152.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    94. Methods for human demographic inference using haplotype patterns from genomewide single-nucleotide polymorphism data. Genetics. 2009 May; 182(1):217-31. Lohmueller KE, Bustamante CD, Clark AG. PMID: 19255370; PMCID: PMC2674818.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    95. Global distribution of genomic diversity underscores rich complex history of continental human populations. Genome Res. 2009 May; 19(5):795-803. Auton A, Bryc K, Boyko AR, Lohmueller KE, Novembre J, Reynolds A, Indap A, Wright MH, Degenhardt JD, Gutenkunst RN, King KS, Nelson MR, Bustamante CD. PMID: 19218534; PMCID: PMC2675968.
      View in: PubMed   Mentions: 100     Fields:    Translation:Humans
    96. Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genet. 2008 May 30; 4(5):e1000083. Boyko AR, Williamson SH, Indap AR, Degenhardt JD, Hernandez RD, Lohmueller KE, Adams MD, Schmidt S, Sninsky JJ, Sunyaev SR, White TJ, Nielsen R, Clark AG, Bustamante CD. PMID: 18516229; PMCID: PMC2377339.
      View in: PubMed   Mentions: 398     Fields:    Translation:HumansAnimals
    97. Proportionally more deleterious genetic variation in European than in African populations. Nature. 2008 Feb 21; 451(7181):994-7. Lohmueller KE, Indap AR, Schmidt S, Boyko AR, Hernandez RD, Hubisz MJ, Sninsky JJ, White TJ, Sunyaev SR, Nielsen R, Clark AG, Bustamante CD. PMID: 18288194; PMCID: PMC2923434.
      View in: PubMed   Mentions: 221     Fields:    Translation:Humans
    98. Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet. 2008 Feb 05; 9:14. Olshen AB, Gold B, Lohmueller KE, Struewing JP, Satagopan J, Stefanov SA, Eskin E, Kirchhoff T, Lautenberger JA, Klein RJ, Friedman E, Norton L, Ellis NA, Viale A, Lee CS, Borgen PI, Clark AG, Offit K, Boyd J. PMID: 18251999; PMCID: PMC2259380.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    99. Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure. Ann Hum Genet. 2006 Jan; 70(Pt 1):27-41. Lohmueller KE, Wong LJ, Mauney MM, Jiang L, Felder RA, Jose PA, Williams SM. PMID: 16441255.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    100. Variants associated with common disease are not unusually differentiated in frequency across populations. Am J Hum Genet. 2006 Jan; 78(1):130-6. Lohmueller KE, Mauney MM, Reich D, Braverman JM. PMID: 16385456; PMCID: PMC1380210.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    101. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May; 74(5):979-1000. Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. PMID: 15088269; PMCID: PMC1181990.
      View in: PubMed   Mentions: 301     Fields:    Translation:HumansCells
    102. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet. 2003 Feb; 33(2):177-82. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. PMID: 12524541.
      View in: PubMed   Mentions: 580     Fields:    Translation:Humans
    103. A comprehensive review of genetic association studies. Genet Med. 2002 Mar-Apr; 4(2):45-61. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. PMID: 11882781.
      View in: PubMed   Mentions: 571     Fields:    Translation:Humans
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