Timothy Chang

Title(s)	Assistant Professor-in-Residence, Neurology
School	Medicine
ORCID	0000-0002-9225-9874
vCard	Download vCard

Biography

education and training

University of Wisconsin, Madison, Madison	MD	06/2014
University of Wisconsin, Madison, Madison	PhD	06/2012	Clinical Investigation (Biomedical Informatics)
UCLA, Los Angeles		2018	Neurology
UCLA, Los Angeles		2020	Fellowship Movement Disorder
UCLA, Los Angeles		2021	Fellowship Neurobehavior

Overview

overview

The goal of our research laboratory is to incorporate genomics, electronic health records, and biomedical informatics to realize precision medicine for neurodegenerative diseases. To work toward this goal, we leverage our biological and clinical understanding of disease, and ability to apply state-of-the-art biomedical informatic methods to enhance novel discoveries. In addition to research, I am a movement disorder and neurobehavior physician, actively seeing patients with Alzheimer’s disease, dementias and atypical Parkinsonian disorders.
Dr. Chang holds the Augustus S. Rose Chair in Neurology, the director of the UCLA California Alzheimer's disease Center and the director of the Amyloid Immunotherapy Care Program.

webpage

Research Laboratory Website

ORNG Applications

Featured Publications

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Improving genetic risk modeling of dementia from real-world data in underrepresented populations. Commun Biol. 2024 08 25; 7(1):1049. Fu M, Valiente-Banuet L, Wadhwa SS, Pasaniuc B, Vossel K, Chang TS. PMID: 39183196; PMCID: PMC11345412.

View in: PubMed Mentions: Translation:Humans
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy. Mol Neurodegener. 2024 Aug 16; 19(1):61. Wang H, Chang TS, Dombroski BA, Cheng PL, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Rajput A, De Deyn PP, Le Bastard N, Gearing M, Kaat LD, Van Swieten JC, Dopper E, Ghetti BF, Newell KL, Troakes C, de Yébenes JG, Rábano-Gutierrez A, Meller T, Oertel WH, Respondek G, Stamelou M, Arzberger T, Roeber S, Müller U, Hopfner F, Pastor P, Brice A, Durr A, Le Ber I, Beach TG, Serrano GE, Hazrati LN, Litvan I, Rademakers R, Ross OA, Galasko D, Boxer AL, Miller BL, Seeley WW, Van Deerlin VM, Lee EB, White CL, Morris H, de Silva R, Crary JF, Goate AM, Friedman JS, Leung YY, Coppola G, Naj AC, Wang LS, P. S. P. genetics study group, Dalgard C, Dickson DW, Höglinger GU, Schellenberg GD, Geschwind DH, Lee WP. PMID: 39152475; PMCID: PMC11330058.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology Neu Neurology
Translation:Humans
Defining the distance between diseases using SNOMED CT embeddings. J Biomed Inform. 2023 03; 139:104307. Fu M, Yan Y, Olde Loohuis LM, Chang TS. PMID: 36738869.

View in: PubMed Mentions: 1 Fields:
Med Medical Informatics
Translation:Humans
Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records. Front Aging Neurosci. 2022; 14:800375. Fu M, UCLA Precision Health Data Discovery Repository Working Group, UCLA Precision Health ATLAS Working Group, Chang TS. PMID: 35370621; PMCID: PMC8965623.

View in: PubMed Mentions: 5
Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors. iScience. 2021 Mar 19; 24(3):102188. Chang TS, Ding Y, Freund MK, Johnson R, Schwarz T, Yabu JM, Hazlett C, Chiang JN, Wulf DA, UCLA Precision Health Data Discovery Repository Working Group, Geschwind DH, Butte MJ, Pasaniuc B. PMID: 33615196; PMCID: PMC7879099.

View in: PubMed Mentions: 9
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Rep. 2020 11 17; 33(7):108398. Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. PMID: 33207193; PMCID: PMC7842189.

View in: PubMed Mentions: 44 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Identification of Conserved Proteomic Networks in Neurodegenerative Dementia. Cell Rep. 2020 06 23; 31(12):107807. Swarup V, Chang TS, Duong DM, Dammer EB, Dai J, Lah JJ, Johnson ECB, Seyfried NT, Levey AI, Geschwind DH. PMID: 32579933; PMCID: PMC8221021.

View in: PubMed Mentions: 38 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Physicians Voluntarily Using an EHR-Based CDS Tool Improved Patients' Guideline-Related Statin Prescription Rates: A Retrospective Cohort Study. Appl Clin Inform. 2019 05; 10(3):421-445. Chang TS, Buchipudi A, Fonarow GC, Pfeffer MA, Singer JS, Cheng EM. PMID: 31216590; PMCID: PMC6584145.

View in: PubMed Mentions: 4 Fields:
Med Medical Informatics
Translation:Humans
Optimizing Effect Sizes With Imaging Enrichment and Outcome Choices for Mild Alzheimer Disease Clinical Trials. Alzheimer Dis Assoc Disord. 2017 Jan-Mar; 31(1):19-26. Chang TS, Teng E, Elashoff D, Grill JD, Alzheimer’s Disease Neuroimaging Initiative. PMID: 27196535; PMCID: PMC5116001.

View in: PubMed Mentions: 1 Fields:
Neu Neurology Psy Psychiatry
Translation:Humans