Jessica Rexach

Title(s)	Assistant Professor-in-Residence, Neurology
School	Medicine
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Research

Research Activities and Funding

Single cell and tissue level functional genomic analysis of astrocyte-related mechanisms in tauopathy
NIH K08NS105916Sep 15, 2019 - Aug 31, 2024
Role: Principal Investigator

The story of methyl-CpG binding protein 2 glycosylation
NIH F31NS056525Sep 1, 2006 - Aug 31, 2010
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753.

View in: PubMed Mentions: Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron. 2021 07 21; 109(14):2275-2291.e8. Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. PMID: 34133945.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Animals Cells
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Rep. 2020 11 17; 33(7):108398. Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. PMID: 33207193.

View in: PubMed Mentions: 3 Fields:
Cel Cell Biology Mol Molecular Biology
Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults. Neuropsychology. 2020 Nov; 34(8):835-850. Lindbergh CA, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Edwards L, Tsoy E, Elahi F, Walters SM, Cotter D, You M, Apple AC, Asken B, Neuhaus J, Rexach JE, Wojta KJ, Rabinovici G, Kramer JH, Hillblom Aging Network . PMID: 33030915.

View in: PubMed Mentions: Fields:
Neu Neurology Psy Psychology
Translation:Humans
Selective Neuronal Vulnerability in Alzheimer's Disease: A Modern Holy Grail. Neuron. 2020 09 09; 107(5):763-765. Rexach J, Geschwind D. PMID: 32910887.

View in: PubMed Mentions: Fields:
Neu Neurology
Translation:Humans Cells
Emotional detachment, gait ataxia, and cerebellar dysconnectivity associated with compound heterozygous mutations in the SPG7 gene. Neurocase. 2020 10; 26(5):299-304. Ringman JM, Qiao Y, Garbin A, Fisher BE, Fogel B, Watari Knoell K, Chui HC, Shi Y, Rexach JE. PMID: 32893728.

View in: PubMed Mentions: Fields:
Beh Behavioral Sciences Neu Neurology Psy Psychiatry Psy Psychology
Translation:Humans
The Neurodevelopmental and Motor Phenotype of SCA21 (ATX-TMEM240). J Child Neurol. 2020 12; 35(14):953-962. Burdekin ED, Fogel BL, Jeste SS, Martinez J, Rexach JE, DiStefano C, Hyde C, Safari T, Wilson RB. PMID: 32705938.

View in: PubMed Mentions: Fields:
Neu Neurology Ped Pediatrics
A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders. Hum Mutat. 2020 02; 41(2):487-501. Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, Hassin-Baer S, Poke G, Neas K, Geschwind MD, Grody WW, Gibbs R, Geschwind DH, Lupski JR, Below JE, Nelson SF, Fogel BL. PMID: 31692161.

View in: PubMed Mentions: 11 Fields:
Gen Genetics
Translation:Humans Cells
A family with spinocerebellar ataxia and retinitis pigmentosa attributed to an ELOVL4 mutation. Neurol Genet. 2019 10; 5(5):e357. Xiao C, Binkley EM, Rexach J, Knight-Johnson A, Khemani P, Fogel BL, Das S, Stone EM, Gomez CM. PMID: 31750392.

View in: PubMed Mentions:
Clinical application of next-generation sequencing to the practice of neurology. Lancet Neurol. 2019 05; 18(5):492-503. Rexach J, Lee H, Martinez-Agosto JA, Németh AH, Fogel BL. PMID: 30981321.

View in: PubMed Mentions: 13 Fields:
Neu Neurology
Translation:Humans
Next generation sequencing in clinical diagnosis. Lancet Neurol. 2019 May; 18(5):426. Lee H, Martinez-Agosto JA, Rexach J, Fogel BL. PMID: 30981320.

View in: PubMed Mentions: 3 Fields:
Neu Neurology
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nat Med. 2019 01; 25(1):152-164. Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, International Frontotemporal Dementia Genomics Consortium , Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH. PMID: 30510257.

View in: PubMed Mentions: 22 Fields:
Med Medicine (General)Mol Molecular Biology
Translation:Humans Animals Cells
Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15120-15125. Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC. PMID: 27956640.

View in: PubMed Mentions: 58 Fields:
Sci Science
Translation:Humans Animals Cells
A Case of Spinocerebellar Ataxia With a Reversible Splenium Lesion Due to Malnutrition and Vitamin Deficiency. J Clin Neuromuscul Dis. 2015 Dec; 17(2):95-7. Trikamji B, Rexach J, Mishra SK. PMID: 26583499.

View in: PubMed Mentions: Fields:
Neu Neurology Phy Physiology
Translation:Humans
Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags. Curr Protoc Chem Biol. 2013; 5(4):281-302. Clark PM, Rexach JE, Hsieh-Wilson LC. PMID: 24391098.

View in: PubMed Mentions: 7 Fields:
Bio Biochemistry Che Chemistry Techniques
Translation:Humans Animals Cells
Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation. Nat Chem Biol. 2012 Jan 22; 8(3):253-61. Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. PMID: 22267118.

View in: PubMed Mentions: 84 Fields:
Bio Biology Che Chemistry
Translation:Animals Cells
Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags. Nat Chem Biol. 2010 Sep; 6(9):645-51. Rexach JE, Rogers CJ, Yu SH, Tao J, Sun YE, Hsieh-Wilson LC. PMID: 20657584.

View in: PubMed Mentions: 82 Fields:
Bio Biology Che Chemistry
Translation:Cells
Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nat Chem Biol. 2008 Feb; 4(2):97-106. Rexach JE, Clark PM, Hsieh-Wilson LC. PMID: 18202679.

View in: PubMed Mentions: 53 Fields:
Bio Biology Che Chemistry
Translation:Humans Animals Cells
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics. Nat Chem Biol. 2007 Jun; 3(6):339-48. Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. PMID: 17496889.

View in: PubMed Mentions: 147 Fields:
Bio Biology Che Chemistry
Translation:Animals Cells