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Jessica Rexach

Title(s)Assistant Professor-in-Residence, Neurology
SchoolMedicine
Emailjrexach@mednet.ucla.edu
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    Collapse Overview 
    Collapse overview
    Jessica Rexach, M.D., Ph.D., previously held the John Douglas French Alzheimer's Foundation Endowed Chair (7/1/2020 - 6/30/2025).

    Collapse Research 
    Collapse research activities and funding
    Single cell and tissue level functional genomic analysis of astrocyte-related mechanisms in tauopathy
    NIH K08NS105916Sep 15, 2019 - Aug 31, 2024
    Role: Principal Investigator
    The story of methyl-CpG binding protein 2 glycosylation
    NIH F31NS056525Sep 1, 2006 - Aug 31, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALS. bioRxiv. 2025 Aug 25. Gautier O, Blum JA, Nguyen TP, Klemm S, Yamakawa M, Sinnott-Armstrong N, Zeng Y, Davis CO, Bombosch J, Nakayama L, Guttenplan KA, Chen D, Kathira A, Zhao L, Rexach JE, Greenleaf WJ, Gitler AD. PMID: 40909710; PMCID: PMC12407787.
      View in: PubMed   Mentions:
    2. BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults. Alzheimers Dement (N Y). 2025 Apr-Jun; 11(2):e70106. Cadwallader CJ, VandeBunte AM, Fischer DL, Chen C, Diaz VE, Lee SY, Chan B, Lario-Lago A, Rojas JC, Ramos EM, Rexach JE, Yokoyama JS, Kramer JH, Paolillo EW, Saloner R, Casaletto KB. PMID: 40547329; PMCID: PMC12178939.
      View in: PubMed   Mentions:
    3. Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states. bioRxiv. 2025 Jun 04. Han X, Zhang T, Lee CY, Ravi A, Spina S, Li AN, Grinberg LT, Seeley WW, Huckins LM, Raj T, Brennand KJ, Rexach JE. PMID: 40502140; PMCID: PMC12157633.
      View in: PubMed   Mentions:
    4. Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference. Alzheimers Dement. 2025 Jan; 21(1):e14291. Kloske CM, Mahinrad S, Barnum CJ, Batista AF, Bradshaw EM, Butts B, Carrillo MC, Chakrabarty P, Chen X, Craft S, Da Mesquita S, Dabin LC, Devanand D, Duran-Laforet V, Elyaman W, Evans EE, Fitzgerald-Bocarsly P, Foley KE, Harms AS, Heneka MT, Hong S, Huang YA, Jackvony S, Lai L, Guen YL, Lemere CA, Liddelow SA, Martin-Peña A, Orr AG, Quintana FJ, Ramey GD, Rexach JE, Rizzo SJS, Sexton C, Tang AS, Torrellas JG, Tsai AP, van Olst L, Walker KA, Wharton W, Tansey MG, Wilcock DM. PMID: 39692624; PMCID: PMC11772715.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics. Cell. 2024 Oct 03; 187(20):5753-5774.e28. Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Han X, Yamakawa M, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. PMID: 39265576; PMCID: PMC12017262.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. CSF Proteomics in Patients With Progressive Supranuclear Palsy. Neurology. 2024 Aug 13; 103(3):e209585. Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, Sivasankaran R, Palma JA, Mitic L, Heuer HW, Lario-Lago A, Staffaroni AM, Clark A, Taylor J, Ljubenkov PA, Vandevrede L, Grinberg LT, Spina S, Seeley WW, Miller BL, Boeve BF, Dickerson BC, Grossman M, Litvan I, Pantelyat A, Tartaglia MC, Zhang Z, Wills AA, Rexach J, Rojas JC, Boxer AL, as the 4-Repeat Tauopathy Neuroimaging Initiative. PMID: 38959435; PMCID: PMC11226322.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study. JMIR Aging. 2024 Jun 26; 7:e52831. Paolillo EW, Casaletto KB, Clark AL, Taylor JC, Heuer HW, Wise AB, Dhanam S, Sanderson-Cimino M, Saloner R, Kramer JH, Kornak J, Kremers W, Forsberg L, Appleby B, Bayram E, Bozoki A, Brushaber D, Darby RR, Day GS, Dickerson BC, Domoto-Reilly K, Elahi F, Fields JA, Ghoshal N, Graff-Radford N, G H Hall M, Honig LS, Huey ED, Lapid MI, Litvan I, Mackenzie IR, Masdeu JC, Mendez MF, Mester C, Miyagawa T, Naasan G, Pascual B, Pressman P, Ramos EM, Rankin KP, Rexach J, Rojas JC, VandeVrede L, Wong B, Wszolek ZK, Boeve BF, Rosen HJ, Boxer AL, Staffaroni AM, ALLFTD Consortium. PMID: 38922667; PMCID: PMC11237775.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Loss of TBC1D2B causes a progressive neurological disorder with gingival overgrowth. Eur J Hum Genet. 2024 May; 32(5):558-566. Harms FL, Rexach JE, Efthymiou S, Aynekin B, Per H, Güleç A, Nampoothiri S, Sampaio H, Sachdev R, Stoeva R, Myers K, Pena LDM, Kalfa TA, Chard M, Klassen M, Pries M, Kutsche K. PMID: 38374468; PMCID: PMC11061173.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Cell States and Interactions of CD8 T Cells and Disease-Enriched Microglia in Human Brains with Alzheimer's Disease. Biomedicines. 2024 Jan 29; 12(2). Yamakawa M, Rexach JE. PMID: 38397909; PMCID: PMC10886701.
      View in: PubMed   Mentions: 4  
    10. Novel avenues of tau research. Alzheimers Dement. 2024 03; 20(3):2240-2261. Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. PMID: 38170841; PMCID: PMC10984447.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    11. Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. bioRxiv. 2023 Sep 30. Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. PMID: 37808727; PMCID: PMC10557766.
      View in: PubMed   Mentions: 1  
    12. Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults. Alzheimers Dement. 2023 08; 19(8):3448-3457. Saloner R, Paolillo EW, Wojta KJ, Fonseca C, Gontrum EQ, Lario-Lago A, Rabinovici GD, Yokoyama JS, Rexach JE, Kramer JH, Casaletto KB. PMID: 36807763; PMCID: PMC10435666.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system. Front Immunol. 2022; 13:1056417. Houser MC, Uriarte Huarte O, Wallings RL, Keating CE, MacPherson KP, Herrick MK, Kannarkat GT, Kelly SD, Chang J, Varvel NH, Rexach JE, Tansey MG. PMID: 36618392; PMCID: PMC9814971.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    15. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron. 2021 07 21; 109(14):2275-2291.e8. Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. PMID: 34133945; PMCID: PMC8298293.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    16. Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Rep. 2020 11 17; 33(7):108398. Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. PMID: 33207193; PMCID: PMC7842189.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    17. Sex-related differences in the relationship between β-amyloid and cognitive trajectories in older adults. Neuropsychology. 2020 Nov; 34(8):835-850. Lindbergh CA, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Edwards L, Tsoy E, Elahi F, Walters SM, Cotter D, You M, Apple AC, Asken B, Neuhaus J, Rexach JE, Wojta KJ, Rabinovici G, Kramer JH, Hillblom Aging Network. PMID: 33030915; PMCID: PMC7839841.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Selective Neuronal Vulnerability in Alzheimer's Disease: A Modern Holy Grail. Neuron. 2020 09 09; 107(5):763-765. Rexach J, Geschwind D. PMID: 32910887.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Emotional detachment, gait ataxia, and cerebellar dysconnectivity associated with compound heterozygous mutations in the SPG7 gene. Neurocase. 2020 10; 26(5):299-304. Ringman JM, Qiao Y, Garbin A, Fisher BE, Fogel B, Watari Knoell K, Chui HC, Shi Y, Rexach JE. PMID: 32893728; PMCID: PMC7530119.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. The Neurodevelopmental and Motor Phenotype of SCA21 (ATX-TMEM240). J Child Neurol. 2020 12; 35(14):953-962. Burdekin ED, Fogel BL, Jeste SS, Martinez J, Rexach JE, DiStefano C, Hyde C, Safari T, Wilson RB. PMID: 32705938; PMCID: PMC7674185.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. A diagnostic ceiling for exome sequencing in cerebellar ataxia and related neurological disorders. Hum Mutat. 2020 02; 41(2):487-501. Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, Hassin-Baer S, Poke G, Neas K, Geschwind MD, Grody WW, Gibbs R, Geschwind DH, Lupski JR, Below JE, Nelson SF, Fogel BL. PMID: 31692161; PMCID: PMC7182470.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    22. A family with spinocerebellar ataxia and retinitis pigmentosa attributed to an ELOVL4 mutation. Neurol Genet. 2019 10; 5(5):e357. Xiao C, Binkley EM, Rexach J, Knight-Johnson A, Khemani P, Fogel BL, Das S, Stone EM, Gomez CM. PMID: 31750392; PMCID: PMC6812731.
      View in: PubMed   Mentions: 21  
    23. Clinical application of next-generation sequencing to the practice of neurology. Lancet Neurol. 2019 05; 18(5):492-503. Rexach J, Lee H, Martinez-Agosto JA, Németh AH, Fogel BL. PMID: 30981321; PMCID: PMC7055532.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    24. Next generation sequencing in clinical diagnosis. Lancet Neurol. 2019 May; 18(5):426. Lee H, Martinez-Agosto JA, Rexach J, Fogel BL. PMID: 30981320.
      View in: PubMed   Mentions: 9     Fields:    
    25. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nat Med. 2019 01; 25(1):152-164. Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, International Frontotemporal Dementia Genomics Consortium, Grossman M, Van Deerlin VM, Trojanowski JQ, Lah JJ, Levey AI, Kondou S, Geschwind DH. PMID: 30510257; PMCID: PMC6602064.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    26. Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration. Proc Natl Acad Sci U S A. 2016 12 27; 113(52):15120-15125. Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC. PMID: 27956640; PMCID: PMC5206508.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    27. A Case of Spinocerebellar Ataxia With a Reversible Splenium Lesion Due to Malnutrition and Vitamin Deficiency. J Clin Neuromuscul Dis. 2015 Dec; 17(2):95-7. Trikamji B, Rexach J, Mishra SK. PMID: 26583499.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags. Curr Protoc Chem Biol. 2013; 5(4):281-302. Clark PM, Rexach JE, Hsieh-Wilson LC. PMID: 24391098; PMCID: PMC3931299.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    29. Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation. Nat Chem Biol. 2012 Jan 22; 8(3):253-61. Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC. PMID: 22267118; PMCID: PMC3288555.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    30. Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags. Nat Chem Biol. 2010 Sep; 6(9):645-51. Rexach JE, Rogers CJ, Yu SH, Tao J, Sun YE, Hsieh-Wilson LC. PMID: 20657584; PMCID: PMC2924450.
      View in: PubMed   Mentions: 101     Fields:    Translation:Cells
    31. Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nat Chem Biol. 2008 Feb; 4(2):97-106. Rexach JE, Clark PM, Hsieh-Wilson LC. PMID: 18202679; PMCID: PMC3250351.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    32. Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics. Nat Chem Biol. 2007 Jun; 3(6):339-48. Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC. PMID: 17496889.
      View in: PubMed   Mentions: 186     Fields:    Translation:AnimalsCells
    33. The Chlamydomonas reinhardtii Nar1 gene encodes a chloroplast membrane protein involved in nitrite transport. Plant Cell. 2000 Aug; 12(8):1441-53. Rexach J, Fernández E, Galván A. PMID: 10948261; PMCID: PMC149114.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
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