Ye Zhang

Title(s)Associate Professor-in-residence, Psychiatry and Biobehavioral Sciences
SchoolMedicine
ORCID ORCID Icon0000-0002-1546-5930 Additional info
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    Collapse Biography 
    Collapse education and training
    Tsinghua University, Beijing, ChinaB.S.06/2003Biological Sciences
    University of California San Francisco, San Francisco CAPh.D.12/2009Neuroscience
    Stanford University, Stanford CAPostdoc05/2016Neurobiology

    Collapse Overview 
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    Dr. Zhang's research is focused on glia biology in health and disease.
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    Collapse Research 
    Collapse research activities and funding
    Identification of candidate juvenile protective factors in neuron, glia, and vascular cells of human and mouse brain
    NIH R03AG065772Sep 30, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Molecular characterization of reactive astrocytes in humans
    NIH R01NS109025Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Identification of transcription factors that regulate astrocyte differentiation
    NIH R00NS089780Apr 1, 2017 - Mar 31, 2020
    Role: Principal Investigator
    Identification of transcription factors that regulate astrocyte differentiation
    NIH K99NS089780Sep 30, 2014 - May 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Secretome analysis of oligodendrocytes and precursors reveals their roles as contributors to the extracellular matrix and potential regulators of inflammation. bioRxiv. 2024 Jul 23. Godoy MI, Pandey V, Wohlschlegel JA, Zhang Y. PMID: 39091874; PMCID: PMC11291107.
      View in: PubMed   Mentions:
    2. β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice. J Neurosci. 2023 12 13; 43(50):8621-8636. Rosenberg MF, Godoy MI, Wade SD, Paredes MF, Zhang Y, Molofsky AV. PMID: 37845031; PMCID: PMC10727121.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes. Neurosci Lett. 2023 08 10; 811:137354. Krawczyk MC, Godoy M, Vander P, Zhang AJ, Zhang Y. PMID: 37348749; PMCID: PMC11473033.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Prdm16 and Vcam1 regulate the postnatal disappearance of radial glia and the ending of cortical neurogenesis. BioRxiv. 2023. Li J*, Godoy M*, Zhang AJ, Diamante G, Ahn IS, Cebrian-Silla A, Alvarez-Buylla A, Yang X, Novitch BG, and Zhang Y.
    5. Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia. PLoS One. 2023; 18(2):e0279736. Krawczyk MC, Pan L, Zhang AJ, Zhang Y. PMID: 36827449; PMCID: PMC9956607.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. Elife. 2023 02 13; 12. Pan L, Trimarco A, Zhang AJ, Fujimori K, Urade Y, Sun LO, Taveggia C, Zhang Y. PMID: 36779701; PMCID: PMC9946447.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    7. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022 11; 25(11):1528-1542. Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. PMID: 36303069; PMCID: PMC9633461.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    8. Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process. Cell Rep. 2022 10 18; 41(3):111474. Sapkota D, Kater MSJ, Sakers K, Nygaard KR, Liu Y, Koester SK, Fass SB, Lake AM, Khazanchi R, Khankan RR, Krawczyk MC, Smit AB, Maloney SE, Verheijen MHG, Zhang Y, Dougherty JD. PMID: 36261025; PMCID: PMC9624251.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    9. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures. J Neurosci. 2022 02 23; 42(8):1587-1603. Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y. PMID: 34987109; PMCID: PMC8883850.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    10. Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes. Commun Biol. 2021 09 14; 4(1):1076. Li Z, Siddique I, Hadrovic I, Kirupakaran A, Li J, Zhang Y, Klärner FG, Schrader T, Bitan G. PMID: 34521989; PMCID: PMC8440717.
      View in: PubMed   Mentions: 6  Translation:HumansAnimalsCells
    11. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. Nat Commun. 2021 06 25; 12(1):3958. Li J, Pan L, Pembroke WG, Rexach JE, Godoy MI, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, Zhang Y. PMID: 34172753; PMCID: PMC8233314.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    12. Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation. Glia. 2019 08; 67(8):1571-1597. Li J, Khankan RR, Caneda C, Godoy MI, Haney MS, Krawczyk MC, Bassik MC, Sloan SA, Zhang Y. PMID: 31033049; PMCID: PMC6557696.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    13. Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma. Cell Rep. 2017 10 31; 21(5):1399-1410. Darmanis S, Sloan SA, Croote D, Mignardi M, Chernikova S, Samghababi P, Zhang Y, Neff N, Kowarsky M, Caneda C, Li G, Chang SD, Connolly ID, Li Y, Barres BA, Gephart MH, Quake SR. PMID: 29091775; PMCID: PMC5810554.
      View in: PubMed   Mentions: 487     Fields:    Translation:Humans
    14. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 2017 Oct 10; 21(2):517-532. Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG. PMID: 29020636; PMCID: PMC5637483.
      View in: PubMed   Mentions: 203     Fields:    Translation:HumansCells
    15. Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination. PLoS Genet. 2015 Dec; 11(12):e1005669. Dong X, Chen K, Cuevas-Diaz Duran R, You Y, Sloan SA, Zhang Y, Zong S, Cao Q, Barres BA, Wu JQ. PMID: 26683846; PMCID: PMC4980008.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    16. Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse. Neuron. 2016 Jan 06; 89(1):37-53. Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MS, Li G, Duncan JA, Cheshier SH, Shuer LM, Chang EF, Grant GA, Gephart MG, Barres BA. PMID: 26687838; PMCID: PMC4707064.
      View in: PubMed   Mentions: 1037     Fields:    Translation:HumansAnimalsCells
    17. Electrophysiological properties of NG2(+) cells: Matching physiological studies with gene expression profiles. Brain Res. 2016 May 01; 1638(Pt B):138-160. Larson VA, Zhang Y, Bergles DE. PMID: 26385417; PMCID: PMC4792778.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    18. A survey of human brain transcriptome diversity at the single cell level. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7285-90. Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden Gephart MG, Barres BA, Quake SR. PMID: 26060301; PMCID: PMC4466750.
      View in: PubMed   Mentions: 647     Fields:    Translation:HumansCells
    19. Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):3445-50. Yan Q, Weyn-Vanhentenryck SM, Wu J, Sloan SA, Zhang Y, Chen K, Wu JQ, Barres BA, Zhang C. PMID: 25737549; PMCID: PMC4371929.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    20. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci. 2014 Sep 03; 34(36):11929-47. Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, Wu JQ. PMID: 25186741; PMCID: PMC4152602.
      View in: PubMed   Mentions: 2545     Fields:    Translation:AnimalsCells
    21. A smarter mouse with human astrocytes. Bioessays. 2013 Oct; 35(10):876-80. Zhang Y, Barres BA. PMID: 23897758.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol. 2010 Oct; 20(5):588-94. Zhang Y, Barres BA. PMID: 20655735.
      View in: PubMed   Mentions: 277     Fields:    Translation:HumansAnimalsCells
    23. Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol. 2008 Oct; 10(10):1172-80. Zheng Y, Wildonger J, Ye B, Zhang Y, Kita A, Younger SH, Zimmerman S, Jan LY, Jan YN. PMID: 18758451; PMCID: PMC2588425.
      View in: PubMed   Mentions: 146     Fields:    
    24. Growing dendrites and axons differ in their reliance on the secretory pathway. Cell. 2007 Aug 24; 130(4):717-29. Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN. PMID: 17719548; PMCID: PMC2020851.
      View in: PubMed   Mentions: 169     Fields:    
    25. The secretory pathway and neuron polarization. J Neurosci. 2006 Oct 18; 26(42):10631-2. Ye B, Zhang YW, Jan LY, Jan YN. PMID: 17050701; PMCID: PMC6674765.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
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