-
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders. Cold Spring Harb Perspect Biol. 2024 Jul 01; 16(7).
Liddelow SA, Olsen ML, Sofroniew MV. PMID: 38316554; PMCID: PMC11216178.
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Translation:
HumansAnimalsCells
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Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice. Nat Neurosci. 2024 Aug; 27(8):1505-1521.
O'Shea TM, Ao Y, Wang S, Ren Y, Cheng AL, Kawaguchi R, Shi Z, Swarup V, Sofroniew MV. PMID: 38907165; PMCID: PMC11303254.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica. Nature. 2024 Jul; 631(8019):150-163.
Skinnider MA, Gautier M, Teo AYY, Kathe C, Hutson TH, Laskaratos A, de Coucy A, Regazzi N, Aureli V, James ND, Schneider B, Sofroniew MV, Barraud Q, Bloch J, Anderson MA, Squair JW, Courtine G. PMID: 38898272.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Astrocyte cells in the brain have immune memory. Nature. 2024 Mar; 627(8005):744-745.
Sofroniew MV. PMID: 38509288.
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PubMed Mentions: Fields:
Translation:
Cells
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A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences. Nat Commun. 2023 11 16; 14(1):7426.
Gleichman AJ, Kawaguchi R, Sofroniew MV, Carmichael ST. PMID: 37973910; PMCID: PMC10654773.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Astrocytes in human central nervous system diseases: a frontier for new therapies. Signal Transduct Target Ther. 2023 10 13; 8(1):396.
Verkhratsky A, Butt A, Li B, Illes P, Zorec R, Semyanov A, Tang Y, Sofroniew MV. PMID: 37828019; PMCID: PMC10570367.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023 09 22; 381(6664):1338-1345.
Squair JW, Milano M, de Coucy A, Gautier M, Skinnider MA, James ND, Cho N, Lasne A, Kathe C, Hutson TH, Ceto S, Baud L, Galan K, Aureli V, Laskaratos A, Barraud Q, Deming TJ, Kohman RE, Schneider BL, He Z, Bloch J, Sofroniew MV, Courtine G, Anderson MA. PMID: 37733871.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Hyaline protoplasmic astrocytopathy in epilepsy. Neuropathology. 2023 Dec; 43(6):441-456.
Magaki S, Haeri M, Szymanski LJ, Chen Z, Diaz R, Williams CK, Chang JW, Ao Y, Newell KL, Khanlou N, Yong WH, Fallah A, Salamon N, Daniel T, Cotter J, Hawes D, Sofroniew M, Vinters HV. PMID: 37198977.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature. 2023 Apr; 616(7956):E6.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV. PMID: 36977770.
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PubMed Mentions: Fields:
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Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022 11 02; 13(1):6581.
Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. PMID: 36323693; PMCID: PMC9630454.
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PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022 11; 25(11):1528-1542.
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. PMID: 36303069; PMCID: PMC9633461.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice. Nat Commun. 2022 09 28; 13(1):5702.
O'Shea TM, Ao Y, Wang S, Wollenberg AL, Kim JH, Ramos Espinoza RA, Czechanski A, Reinholdt LG, Deming TJ, Sofroniew MV. PMID: 36171203; PMCID: PMC9519954.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice. Nat Commun. 2022 07 29; 13(1):4418.
Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, Gao K, Potter K, Gilbert HY, Ao Y, Ou J, Fricano-Kugler CJ, Goldberg JL, He Z, Woolf CJ, Sofroniew MV, Benowitz LI, Geschwind DH. PMID: 35906210; PMCID: PMC9338053.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature. 2022 06; 606(7914):557-564.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV. PMID: 35614216; PMCID: PMC10027402.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Correction to: Loss‑of‑function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation. Cell Tissue Res. 2022 May; 388(2):485.
Wahane S, Sofroniew MV. PMID: 35366111; PMCID: PMC9035416.
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PubMed Mentions: Fields:
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Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age. Nat Commun. 2022 04 04; 13(1):1794.
Mills WA, Woo AM, Jiang S, Martin J, Surendran D, Bergstresser M, Kimbrough IF, Eyo UB, Sofroniew MV, Sontheimer H. PMID: 35379828; PMCID: PMC8980042.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
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Lineage tracing: The gold standard to claim direct reprogramming in vivo. Mol Ther. 2022 03 02; 30(3):988-989.
Svendsen CN, Sofroniew MV. PMID: 35123656; PMCID: PMC8899699.
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PubMed Mentions:
4 Fields:
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Engineering spinal cord repair. Curr Opin Biotechnol. 2021 12; 72:48-53.
Squair JW, Gautier M, Sofroniew MV, Courtine G, Anderson MA. PMID: 34695766.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation. Cell Rep. 2021 08 10; 36(6):109508.
Diaz-Castro B, Bernstein AM, Coppola G, Sofroniew MV, Khakh BS. PMID: 34380036; PMCID: PMC8418871.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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HepaCAM shapes astrocyte territories, stabilizes gap-junction coupling, and influences neuronal excitability. Neuron. 2021 08 04; 109(15):2365-2367.
Sofroniew MV. PMID: 34352210.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation. Cell Tissue Res. 2022 Mar; 387(3):337-350.
Wahane S, Sofroniew MV. PMID: 34164732; PMCID: PMC8975763.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325.
Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. PMID: 33589835; PMCID: PMC8007081.
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PubMed Mentions:
776 Fields:
Translation:
HumansAnimalsCells
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Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research. J Neurotrauma. 2021 05 01; 38(9):1251-1266.
Morse LR, Field-Fote EC, Contreras-Vidal J, Noble-Haeusslein LJ, Rodreick M, Shields RK, Sofroniew M, Wudlick R, Zanca JM, SCI 2020 Working Group. PMID: 33353467.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Inflammation drives fibrotic scars in the CNS. Nat Neurosci. 2021 02; 24(2):157-159.
Sofroniew MV. PMID: 33526921.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions. Nat Commun. 2020 12 04; 11(1):6203.
O'Shea TM, Wollenberg AL, Kim JH, Ao Y, Deming TJ, Sofroniew MV. PMID: 33277474; PMCID: PMC7718896.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity. Trends Immunol. 2020 09; 41(9):758-770.
Sofroniew MV. PMID: 32819810; PMCID: PMC7484257.
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PubMed Mentions:
265 Fields:
Translation:
HumansAnimalsCells
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Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma. PLoS One. 2020; 15(7):e0219632.
Garrett MC, O'Shea TM, Wollenberg AL, Bernstein AM, Hung D, Staarman B, Soto H, Deming TJ, Sofroniew MV, Kornblum HI. PMID: 32706829; PMCID: PMC7380637.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression. Sci Rep. 2019 07 10; 9(1):10010.
Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR. PMID: 31292459; PMCID: PMC6620300.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Spinal cord repair: advances in biology and technology. Nat Med. 2019 06; 25(6):898-908.
Courtine G, Sofroniew MV. PMID: 31160817.
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PubMed Mentions:
174 Fields:
Translation:
HumansAnimals
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Astrocytes usurp neurons as a disease focus. Nat Neurosci. 2019 04; 22(4):512-513.
Liddelow SA, Sofroniew MV. PMID: 30858602.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP. Cell Stem Cell. 2018 11 01; 23(5):630-631.
Sofroniew MV. PMID: 30388417.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018 09; 561(7723):396-400.
Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, Kawaguchi R, Coppola G, Wang C, Deming TJ, He Z, Courtine G, Sofroniew MV. PMID: 30158698; PMCID: PMC6151128.
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PubMed Mentions:
202 Fields:
Translation:
AnimalsCells
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Dissecting spinal cord regeneration. Nature. 2018 05; 557(7705):343-350.
Sofroniew MV. PMID: 29769671.
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PubMed Mentions:
129 Fields:
Translation:
HumansAnimalsCells
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Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. Biomaterials. 2018 09; 178:527-545.
Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ. PMID: 29657091; PMCID: PMC6054810.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E302-E309.
Itoh N, Itoh Y, Tassoni A, Ren E, Kaito M, Ohno A, Ao Y, Farkhondeh V, Johnsonbaugh H, Burda J, Sofroniew MV, Voskuhl RR. PMID: 29279367; PMCID: PMC5777065.
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PubMed Mentions:
131 Fields:
Translation:
AnimalsCells
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Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation. J Am Chem Soc. 2017 10 25; 139(42):15114-15121.
Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ. PMID: 28976744; PMCID: PMC6037417.
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PubMed Mentions:
12 Fields:
Translation:
Cells
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Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017 Aug 01; 127(8):3136-3151.
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. PMID: 28737509; PMCID: PMC5531407.
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PubMed Mentions:
114 Fields:
Translation:
HumansAnimalsCells
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Cell biology of spinal cord injury and repair. J Clin Invest. 2017 Sep 01; 127(9):3259-3270.
O'Shea TM, Burda JE, Sofroniew MV. PMID: 28737515; PMCID: PMC5669582.
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PubMed Mentions:
223 Fields:
Translation:
AnimalsCells
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Seducing astrocytes to the dark side. Cell Res. 2017 Jun; 27(6):726-727.
Burda JE, Sofroniew MV. PMID: 28303889; PMCID: PMC5518868.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury. Sci Rep. 2017 01 24; 7:41122.
Ren Y, Ao Y, O'Shea TM, Burda JE, Bernstein AM, Brumm AJ, Muthusamy N, Ghashghaei HT, Carmichael ST, Cheng L, Sofroniew MV. PMID: 28117356; PMCID: PMC5259707.
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PubMed Mentions:
66 Fields:
Translation:
AnimalsCells
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P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neurosci. 2016 08 24; 36(34):8902-20.
Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS. PMID: 27559172; PMCID: PMC4995303.
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PubMed Mentions:
28 Fields:
Translation:
AnimalsCells
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Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016 Apr 14; 532(7598):195-200.
Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV. PMID: 27027288; PMCID: PMC5243141.
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PubMed Mentions:
815 Fields:
Translation:
AnimalsCells
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Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival. Glia. 2016 May; 64(5):668-94.
Levine J, Kwon E, Paez P, Yan W, Czerwieniec G, Loo JA, Sofroniew MV, Wanner IB. PMID: 26683444; PMCID: PMC4805454.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Astrocytes: a central element in neurological diseases. Acta Neuropathol. 2016 Mar; 131(3):323-45.
Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A. PMID: 26671410.
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PubMed Mentions:
359 Fields:
Translation:
HumansAnimalsCells
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Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13360-5.
Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng L, Yang Z, Sun YE, Li X. PMID: 26460053; PMCID: PMC4629389.
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PubMed Mentions:
61 Fields:
Translation:
Animals
-
Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci. 2015 Jul; 18(7):942-52.
Khakh BS, Sofroniew MV. PMID: 26108722; PMCID: PMC5258184.
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PubMed Mentions:
521 Fields:
Translation:
AnimalsCells
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Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery. ACS Biomater Sci Eng. 2015 Aug 10; 1(8):705-717.
Zhang S, Burda JE, Anderson MA, Zhao Z, Ao Y, Cheng Y, Sun Y, Deming TJ, Sofroniew MV. PMID: 27547820; PMCID: PMC4991036.
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PubMed Mentions:
16 Fields:
-
Astrocyte barriers to neurotoxic inflammation. Nat Rev Neurosci. 2015 May; 16(5):249-63.
Sofroniew MV. PMID: 25891508; PMCID: PMC5253239.
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PubMed Mentions:
527 Fields:
Translation:
HumansAnimalsCells
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Astrocyte roles in traumatic brain injury. Exp Neurol. 2016 Jan; 275 Pt 3:305-315.
Burda JE, Bernstein AM, Sofroniew MV. PMID: 25828533; PMCID: PMC4586307.
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PubMed Mentions:
336 Fields:
Translation:
HumansAnimalsCells
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Design and synthesis of nonionic copolypeptide hydrogels with reversible thermoresponsive and tunable physical properties. Biomacromolecules. 2015 Apr 13; 16(4):1331-40.
Zhang S, Alvarez DJ, Sofroniew MV, Deming TJ. PMID: 25748800; PMCID: PMC5247266.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators. J Vis Exp. 2014 Nov 19; (93):e51972.
Jiang R, Haustein MD, Sofroniew MV, Khakh BS. PMID: 25490346; PMCID: PMC4354287.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Astrogliosis. Cold Spring Harb Perspect Biol. 2014 Nov 07; 7(2):a020420.
Sofroniew MV. PMID: 25380660; PMCID: PMC4315924.
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PubMed Mentions:
320 Fields:
Translation:
Cells
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Glia in the pathogenesis of neurodegenerative diseases. Biochem Soc Trans. 2014 Oct; 42(5):1291-301.
Verkhratsky A, Parpura V, Pekna M, Pekny M, Sofroniew M. PMID: 25233406.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity. PLoS One. 2014; 9(7):e102003.
O'Callaghan JP, Kelly KA, VanGilder RL, Sofroniew MV, Miller DB. PMID: 25025494; PMCID: PMC4098997.
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PubMed Mentions:
73 Fields:
Translation:
AnimalsCells
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Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Sep 15; 274(1-2):53-61.
Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR. PMID: 25005117; PMCID: PMC4343306.
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PubMed Mentions:
80 Fields:
Translation:
AnimalsCells
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Memantine enhances recovery from stroke. Stroke. 2014 Jul; 45(7):2093-2100.
López-Valdés HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan KC. PMID: 24938836; PMCID: PMC4142682.
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PubMed Mentions:
50 Fields:
Translation:
Animals
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Astrocytes and Huntington's disease. ACS Chem Neurosci. 2014 Jul 16; 5(7):494-6.
Khakh BS, Sofroniew MV. PMID: 24842291; PMCID: PMC4102957.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PLoS One. 2014; 9(5):e96318.
Assi H, Espinosa J, Suprise S, Sofroniew M, Doherty R, Zamler D, Lowenstein PR, Castro MG. PMID: 24806510; PMCID: PMC4013007.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone. Stem Cell Res. 2014 Jul; 13(1):48-60.
Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG. PMID: 24835668; PMCID: PMC4096985.
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PubMed Mentions:
14 Fields:
Translation:
Animals
-
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci. 2014 May; 17(5):694-703.
Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS. PMID: 24686787; PMCID: PMC4064471.
View in:
PubMed Mentions:
297 Fields:
Translation:
HumansAnimalsCells
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Reactive gliosis and the multicellular response to CNS damage and disease. Neuron. 2014 Jan 22; 81(2):229-48.
Burda JE, Sofroniew MV. PMID: 24462092; PMCID: PMC3984950.
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PubMed Mentions:
631 Fields:
Translation:
HumansAnimalsCells
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Heterogeneity of reactive astrocytes. Neurosci Lett. 2014 Apr 17; 565:23-9.
Anderson MA, Ao Y, Sofroniew MV. PMID: 24361547; PMCID: PMC3984948.
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PubMed Mentions:
210 Fields:
Translation:
HumansAnimalsCells
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Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system. Biomaterials. 2014 Feb; 35(6):1989-2000.
Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV. PMID: 24314556; PMCID: PMC3984939.
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PubMed Mentions:
16 Fields:
Translation:
Animals
-
Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators. Neuroscientist. 2014 Apr; 20(2):160-72.
Sofroniew MV. PMID: 24106265.
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PubMed Mentions:
166 Fields:
Translation:
HumansAnimalsCells
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Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury. J Neurosci. 2013 Jul 31; 33(31):12870-86.
Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, Ao Y, Sofroniew MV. PMID: 23904622; PMCID: PMC3728693.
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PubMed Mentions:
383 Fields:
Translation:
AnimalsCells
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Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. J Neurosci. 2013 Jun 26; 33(26):10924-33.
Spence RD, Wisdom AJ, Cao Y, Hill HM, Mongerson CR, Stapornkul B, Itoh N, Sofroniew MV, Voskuhl RR. PMID: 23804112; PMCID: PMC3693061.
View in:
PubMed Mentions:
83 Fields:
Translation:
AnimalsCells
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Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol. 2013 May; 141(5):633-47.
Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS. PMID: 23589582; PMCID: PMC3639581.
View in:
PubMed Mentions:
187 Fields:
Translation:
AnimalsCells
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Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012 Oct 17; 32(42):14489-510.
Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. PMID: 23077035; PMCID: PMC3518872.
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PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials. 2012 Dec; 33(35):9105-16.
Song B, Song J, Zhang S, Anderson MA, Ao Y, Yang CY, Deming TJ, Sofroniew MV. PMID: 22985994.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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STAT3-mediated astrogliosis protects myelin development in neonatal brain injury. Ann Neurol. 2012 Nov; 72(5):750-65.
Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA. PMID: 22941903; PMCID: PMC3514566.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
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Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012 Jul; 122(7):2454-68.
Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. PMID: 22653056; PMCID: PMC3386814.
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PubMed Mentions:
341 Fields:
Translation:
HumansAnimalsCells
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Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro. 2012 Apr 05; 4(3).
Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodríguez JJ, Nedergaard M. PMID: 22339481; PMCID: PMC3320215.
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PubMed Mentions:
118 Fields:
Translation:
HumansAnimalsCells
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Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories. Front Behav Neurosci. 2012; 6:3.
Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS. PMID: 22347173; PMCID: PMC3270585.
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PubMed Mentions:
22
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Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types. Methods Mol Biol. 2012; 814:531-44.
Sofroniew MV. PMID: 22144330.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci. 2011 Jun 01; 31(22):8306-19.
Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE. PMID: 21632951; PMCID: PMC3500097.
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PubMed Mentions:
89 Fields:
Translation:
AnimalsCells
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Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8867-72.
Spence RD, Hamby ME, Umeda E, Itoh N, Du S, Wisdom AJ, Cao Y, Bondar G, Lam J, Ao Y, Sandoval F, Suriany S, Sofroniew MV, Voskuhl RR. PMID: 21555578; PMCID: PMC3102368.
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PubMed Mentions:
110 Fields:
Translation:
AnimalsCells
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Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia. 2011 Jun; 59(6):857-68.
Wang X, Imura T, Sofroniew MV, Fushiki S. PMID: 21381115; PMCID: PMC3287075.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Neuromyelitis optica: circulating autoantibodies provoke astrocyte-mediated neural dysfunction. Neurology. 2011 Apr 05; 76(14):1202-3.
Sofroniew MV. PMID: 21368284.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus. Stem Cells. 2010 Nov; 28(11):2053-2064.
Imura T, Wang X, Noda T, Sofroniew MV, Fushiki S. PMID: 21089118; PMCID: PMC4524517.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics. 2010 Oct; 7(4):494-506.
Hamby ME, Sofroniew MV. PMID: 20880511; PMCID: PMC2952540.
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PubMed Mentions:
163 Fields:
Translation:
HumansAnimalsCells
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Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010 Oct; 133(10):2999-3016.
Crawford DK, Mangiardi M, Song B, Patel R, Du S, Sofroniew MV, Voskuhl RR, Tiwari-Woodruff SK. PMID: 20858739; PMCID: PMC2947430.
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PubMed Mentions:
61 Fields:
Translation:
AnimalsCells
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A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nat Neurosci. 2010 Jun; 13(6):759-66.
Shigetomi E, Kracun S, Sofroniew MV, Khakh BS. PMID: 20495558; PMCID: PMC2920135.
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PubMed Mentions:
116 Fields:
Translation:
HumansAnimalsCells
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Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. PLoS One. 2010 Mar 10; 5(3):e9532.
Sarafian TA, Montes C, Imura T, Qi J, Coppola G, Geschwind DH, Sofroniew MV. PMID: 20224768; PMCID: PMC2835741.
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PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
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Astrocytes: biology and pathology. Acta Neuropathol. 2010 Jan; 119(1):7-35.
Sofroniew MV, Vinters HV. PMID: 20012068; PMCID: PMC2799634.
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PubMed Mentions:
2204 Fields:
Translation:
HumansAnimalsCells
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PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19479-84.
Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H. PMID: 19846776; PMCID: PMC2765459.
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PubMed Mentions:
67 Fields:
Translation:
HumansAnimals
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Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009 Dec; 32(12):638-47.
Sofroniew MV. PMID: 19782411; PMCID: PMC2787735.
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PubMed Mentions:
1164 Fields:
Translation:
HumansAnimalsCells
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Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat Neurosci. 2009 Oct; 12(10):1333-42.
Courtine G, Gerasimenko Y, van den Brand R, Yew A, Musienko P, Zhong H, Song B, Ao Y, Ichiyama RM, Lavrov I, Roy RR, Sofroniew MV, Edgerton VR. PMID: 19767747; PMCID: PMC2828944.
View in:
PubMed Mentions:
305 Fields:
Translation:
Animals
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Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci. 2009 Sep 16; 29(37):11511-22.
Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari-Woodruff S, Sofroniew MV. PMID: 19759299; PMCID: PMC2768309.
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PubMed Mentions:
234 Fields:
Translation:
AnimalsCells
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Schwann cell influence on motor neuron regeneration accuracy. Neuroscience. 2009 Sep 29; 163(1):213-21.
Madison RD, Sofroniew MV, Robinson GA. PMID: 19505536; PMCID: PMC2728180.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system. Biomaterials. 2009 May; 30(15):2881-98.
Yang CY, Song B, Ao Y, Nowak AP, Abelowitz RB, Korsak RA, Havton LA, Deming TJ, Sofroniew MV. PMID: 19251318.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11; 29(6):1874-86.
Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H. PMID: 19211894; PMCID: PMC2754186.
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PubMed Mentions:
149 Fields:
Translation:
AnimalsCells
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STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci. 2008 Jul 09; 28(28):7231-43.
Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, Korsak RA, Takeda K, Akira S, Sofroniew MV. PMID: 18614693; PMCID: PMC2583788.
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PubMed Mentions:
471 Fields:
Translation:
AnimalsCells
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Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. J Neurosci. 2008 Jun 25; 28(26):6659-63.
Shigetomi E, Bowser DN, Sofroniew MV, Khakh BS. PMID: 18579739; PMCID: PMC2866443.
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PubMed Mentions:
139 Fields:
Translation:
AnimalsCells
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Glia get excited. Nat Neurosci. 2008 Apr; 11(4):379-80.
Otis TS, Sofroniew MV. PMID: 18368040.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Exp Neurol. 2008 Jun; 211(2):423-32.
Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ. PMID: 18410928; PMCID: PMC9152669.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat Med. 2008 Jan; 14(1):69-74.
Courtine G, Song B, Roy RR, Zhong H, Herrmann JE, Ao Y, Qi J, Edgerton VR, Sofroniew MV. PMID: 18157143; PMCID: PMC2916740.
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PubMed Mentions:
341 Fields:
Translation:
AnimalsCells
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Starring roles for astroglia in barrier pathologies of gut and brain. Lab Invest. 2007 Aug; 87(8):731-6.
Savidge TC, Sofroniew MV, Neunlist M. PMID: 17607301.
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PubMed Mentions:
51 Fields:
Translation:
HumansAnimalsCells
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Paradoxical influence of hippocampal neurogenesis on working memory. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4642-6.
Saxe MD, Malleret G, Vronskaya S, Mendez I, Garcia AD, Sofroniew MV, Kandel ER, Hen R. PMID: 17360577; PMCID: PMC1810330.
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PubMed Mentions:
106 Fields:
Translation:
AnimalsCells
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Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology. 2007 Apr; 132(4):1344-58.
Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV. PMID: 17408650.
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PubMed Mentions:
158 Fields:
Translation:
HumansAnimalsCells
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Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17501-6.
Saxe MD, Battaglia F, Wang JW, Malleret G, David DJ, Monckton JE, Garcia AD, Sofroniew MV, Kandel ER, Santarelli L, Hen R, Drew MR. PMID: 17088541; PMCID: PMC1859958.
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PubMed Mentions:
495 Fields:
Translation:
AnimalsCells
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Essential protective roles of reactive astrocytes in traumatic brain injury. Brain. 2006 Oct; 129(Pt 10):2761-72.
Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. PMID: 16825202.
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PubMed Mentions:
303 Fields:
Translation:
AnimalsCells
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Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia. 2006 Feb; 53(3):277-93.
Imura T, Nakano I, Kornblum HI, Sofroniew MV. PMID: 16267834.
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PubMed Mentions:
48 Fields:
Translation:
AnimalsCells
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PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci. 2005 Nov 16; 25(46):10773-85.
Dougherty JD, Garcia AD, Nakano I, Livingstone M, Norris B, Polakiewicz R, Wexler EM, Sofroniew MV, Kornblum HI, Geschwind DH. PMID: 16291951; PMCID: PMC6725850.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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Reactive astrocytes in neural repair and protection. Neuroscientist. 2005 Oct; 11(5):400-7.
Sofroniew MV. PMID: 16151042.
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PubMed Mentions:
339 Fields:
Translation:
AnimalsCells
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Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 Aug 01; 170(3):413-27.
Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. PMID: 16061694; PMCID: PMC2171475.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci. 2004 Nov; 7(11):1233-41.
Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV. PMID: 15494728.
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PubMed Mentions:
429 Fields:
Translation:
AnimalsCells
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Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci. 2004 Mar 03; 24(9):2143-55.
Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. PMID: 14999065; PMCID: PMC6730429.
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PubMed Mentions:
713 Fields:
Translation:
AnimalsCells
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The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci. 2003 Jul; 18(1):76-84.
Morshead CM, Garcia AD, Sofroniew MV, van Der Kooy D. PMID: 12859339.
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PubMed Mentions:
69 Translation:
AnimalsCells
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The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci. 2003 Apr 01; 23(7):2824-32.
Imura T, Kornblum HI, Sofroniew MV. PMID: 12684469; PMCID: PMC6742109.
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PubMed Mentions:
114 Fields:
Translation:
AnimalsCells
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Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro. J Cereb Blood Flow Metab. 2001 Aug; 21(8):972-81.
Kelly S, Bieneman A, Horsburgh K, Hughes D, Sofroniew MV, McCulloch J, Uney JB. PMID: 11487733.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001; 24:1217-81.
Sofroniew MV, Howe CL, Mobley WC. PMID: 11520933.
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PubMed Mentions:
416 Fields:
Translation:
HumansAnimalsCells
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Pituitary adenylate cyclase-activating polypeptide promotes the survival of basal forebrain cholinergic neurons in vitro and in vivo: comparison with effects of nerve growth factor. Eur J Neurosci. 2000 Jul; 12(7):2273-80.
Takei N, Torres E, Yuhara A, Jongsma H, Otto C, Korhonen L, Abiru Y, Skoglösa Y, Schütz G, Hatanaka H, Sofroniew MV, Lindholm D. PMID: 10947806.
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PubMed Mentions:
14 Translation:
AnimalsCells
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Astrocyte failure as a cause of CNS dysfunction. Mol Psychiatry. 2000 May; 5(3):230-2.
Sofroniew MV. PMID: 10889520.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice. Brain Res. 1999 Jul 17; 835(1):91-5.
Sofroniew MV, Bush TG, Blumauer N, Mucke L, Johnson MH. PMID: 10448200.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 1999 Jun; 23(2):297-308.
Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. PMID: 10399936.
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PubMed Mentions:
466 Fields:
Translation:
AnimalsCells
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Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures. Neuroscience. 1999 Mar; 89(2):429-36.
Kimonides VG, Spillantini MG, Sofroniew MV, Fawcett JW, Herbert J. PMID: 10077325.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Re-expression of p75NTR by adult motor neurons after axotomy is triggered by retrograde transport of a positive signal from axons regrowing through damaged or denervated peripheral nerve tissue. Neuroscience. 1999; 91(1):273-81.
Bussmann KA, Sofroniew MV. PMID: 10336077.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998 Apr 17; 93(2):189-201.
Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. PMID: 9568712.
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PubMed Mentions:
234 Fields:
Translation:
AnimalsCells
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Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1852-7.
Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. PMID: 9465106; PMCID: PMC19202.
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PubMed Mentions:
99 Fields:
Translation:
AnimalsCells
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Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci. 1997 Jul 15; 17(14):5549-59.
Hinks GL, Shah B, French SJ, Campos LS, Staley K, Hughes J, Sofroniew MV. PMID: 9204936; PMCID: PMC6793804.
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PubMed Mentions:
21 Fields:
Translation:
Animals
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Brain-derived neurotrophic factor, acidic and basic fibroblast growth factors, insulin-like growth factor-I, and various antioxidants do not prevent the apoptotic death of developing septal cholinergic neurons following nerve growth factor withdrawal in vitro. Neuroscience. 1997 Feb; 76(3):809-20.
Kew JN, Sofroniew MV. PMID: 9135053.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience. 1996 Nov; 75(1):19-27.
De Lacalle S, Cooper JD, Svendsen CN, Dunnett SB, Sofroniew MV. PMID: 8923519.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats. Neuroscience. 1996 Nov; 75(1):29-35.
Cooper JD, Sofroniew MV. PMID: 8923520.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat. Exp Neurol. 1996 May; 139(1):143-55.
Cooper JD, Skepper JN, Berzaghi MD, Lindholm D, Sofroniew MV. PMID: 8635561.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging? Perspect Dev Neurobiol. 1996; 3(2):133-42.
Svendsen CN, Sofroniew MV. PMID: 8826531.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Nerve growth factor withdrawal induces the apoptotic death of developing septal cholinergic neurons in vitro: protection by cyclic AMP analogue and high potassium. Neuroscience. 1996 Jan; 70(2):329-39.
Kew JN, Smith DW, Sofroniew MV. PMID: 8848143.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Ciliary neurotrophic factor supports p75NGFR-immunoreactive non-cholinergic, but not cholinergic, developing septal neurons in vitro. Neuroscience. 1995 Jun; 66(4):793-804.
Kew JN, Sofroniew MV. PMID: 7651610.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats. Neuroscience. 1994 Oct; 62(3):625-9.
Cooper JD, Lindholm D, Sofroniew MV. PMID: 7532836.
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PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
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Down-regulation of protein kinase C isoform gene expression in degenerating thalamic neurones--lack of induction in reactive glial cells. Biochem Soc Trans. 1994 Aug; 22(3):291S.
Wilson VJ, Oddiah D, Sofroniew MV, Panni MK, Rattray M. PMID: 7821550.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Changes in CCK mRNA in hippocampal neurones following fimbria fornix transection. Neuroreport. 1994 Jun 27; 5(11):1377-80.
Panni MK, Wilson VJ, Capoor U, Sofroniew MV, Rattray M. PMID: 7919204.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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NMDA potentiates NGF-induced sprouting of septal cholinergic fibres. Neuroreport. 1994 Jan 12; 5(4):413-6.
Heisenberg CP, Cooper JD, Berke J, Sofroniew MV. PMID: 8003664.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 1994 Jan; 14(1):75-87.
Svendsen CN, Kew JN, Staley K, Sofroniew MV. PMID: 8283253; PMCID: PMC6576871.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. J Neurosci. 1993 Dec; 13(12):5263-76.
Sofroniew MV, Cooper JD, Svendsen CN, Crossman P, Ip NY, Lindsay RM, Zafra F, Lindholm D. PMID: 8254373; PMCID: PMC6576406.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. J Neurosci. 1993 Sep; 13(9):3818-26.
da Penha Berzaghi M, Cooper J, Castrén E, Zafra F, Sofroniew M, Thoenen H, Lindholm D. PMID: 8366347; PMCID: PMC6576436.
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PubMed Mentions:
45 Fields:
Translation:
AnimalsCells
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Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol. 1993 Apr; 120(2):245-63.
Broadwell RD, Sofroniew MV. PMID: 8491281.
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PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
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Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems. Exp Neurol. 1992 Aug; 117(2):151-75.
Isacson O, Sofroniew MV. PMID: 1379936.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Transgenic modelling of neurodegenerative events gathers momentum. Trends Neurosci. 1991 Dec; 14(12):513-4.
Sofroniew MV, Staley K. PMID: 1726340.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Trophic factor effects on septal cholinergic neurons. Ann N Y Acad Sci. 1991; 640:91-4.
Svendsen CN, Cooper JD, Sofroniew MV. PMID: 1776766.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system. Nature. 1990 Mar 08; 344(6262):158-60.
Greenberg JM, Boehm T, Sofroniew MV, Keynes RJ, Barton SC, Norris ML, Surani MA, Spillantini MG, Rabbitts TH. PMID: 2106626.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons. Brain Res. 1990 Feb 05; 508(2):249-56.
O'Brien TS, Svendsen CN, Isacson O, Sofroniew MV. PMID: 2306616.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science. 1990 Jan 19; 247(4940):338-42.
Sofroniew MV, Galletly NP, Isacson O, Svendsen CN. PMID: 1688664.
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PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
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Allografts of CNS tissue possess a blood-brain barrier. I. Grafts of medial preoptic area in hypogonadal mice. Exp Neurol. 1989 Aug; 105(2):135-51.
Broadwell RD, Charlton HM, Ganong WF, Salcman M, Sofroniew M. PMID: 2753114.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen. Exp Brain Res. 1989; 75(1):213-20.
Isacson O, Riche D, Hantraye P, Sofroniew MV, Maziere M. PMID: 2523313.
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Animals
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Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion. J Chem Neuroanat. 1988 Nov-Dec; 1(6):327-37.
Sofroniew MV, Isacson O. PMID: 3270360.
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AnimalsCells
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Neuropeptide Y, somatostatin, and reduced nicotinamide adenine dinucleotide phosphate diaphorase in the human striatum: a combined immunocytochemical and enzyme histochemical study. Neuroscience. 1987 Mar; 20(3):817-28.
Kowall NW, Ferrante RJ, Beal MF, Richardson EP, Sofroniew MV, Cuello AC, Martin JB. PMID: 2885780.
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18 Fields:
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HumansCells
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Actions of microiontophoretically applied oxytocin, and immunohistochemical localization of oxytocin, vasopressin and neurophysin in the rat caudal medulla. Neurosci Lett. 1980 Jun; 18(2):163-8.
Morris R, Salt TE, Sofroniew MV, Hill RG. PMID: 6133248.
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Translation:
AnimalsCells