Michael Victor Sofroniew

Title(s)Professor, Neurobiology
SchoolMedicine
ORCID ORCID Icon0000­0001­6075­0178 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Ludwig-Maximillians University, MunichMD1981Medicine
    University of Oxford, OxfordDPhil1984Neuroscience

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Reactive astrocytes as therapeutic targets
    Dr. Miriam and Sheldon G. Adelson Medical Research Foundation 20131444Oct 1, 2019 - Sep 30, 2025
    Role: Principal Investigator
    Description: Use genomic screening and loss-of-function studies to identify molecules that mediate or contribute to specific astrocyte functions or dysfunctions in response to CNS damage.
    Engineering astroglial bridges for axons across severe SCI lesions
    NIH R01NS084030Aug 1, 2014 - Mar 31, 2024
    Role: Principal Investigator
    An approach to image calcium in small volumes of astrocytes in vivo
    NIH R21NS071292Jul 1, 2010 - Jun 30, 2012
    Role: Co-Principal Investigator
    Molecular Dissection of Reactive Astrogliosis: STAT3
    NIH R01NS057624Jan 15, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Biology of GFAP-expressing neural progenitors
    NIH R01NS047386Jan 1, 2004 - Dec 31, 2008
    Role: Principal Investigator
    Molecular Dissection of Reactive Astrocyte Biology
    NIH R21NS042693Jul 1, 2002 - May 31, 2005
    Role: Principal Investigator
    Reactive scar-forming astrocytes after spinal cord injur
    NIH R21NS042039Jul 15, 2001 - Jun 30, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders. Cold Spring Harb Perspect Biol. 2024 Jul 01; 16(7). Liddelow SA, Olsen ML, Sofroniew MV. PMID: 38316554; PMCID: PMC11216178.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice. Nat Neurosci. 2024 Aug; 27(8):1505-1521. O'Shea TM, Ao Y, Wang S, Ren Y, Cheng AL, Kawaguchi R, Shi Z, Swarup V, Sofroniew MV. PMID: 38907165; PMCID: PMC11303254.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica. Nature. 2024 Jul; 631(8019):150-163. Skinnider MA, Gautier M, Teo AYY, Kathe C, Hutson TH, Laskaratos A, de Coucy A, Regazzi N, Aureli V, James ND, Schneider B, Sofroniew MV, Barraud Q, Bloch J, Anderson MA, Squair JW, Courtine G. PMID: 38898272.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Astrocyte cells in the brain have immune memory. Nature. 2024 Mar; 627(8005):744-745. Sofroniew MV. PMID: 38509288.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences. Nat Commun. 2023 11 16; 14(1):7426. Gleichman AJ, Kawaguchi R, Sofroniew MV, Carmichael ST. PMID: 37973910; PMCID: PMC10654773.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Astrocytes in human central nervous system diseases: a frontier for new therapies. Signal Transduct Target Ther. 2023 10 13; 8(1):396. Verkhratsky A, Butt A, Li B, Illes P, Zorec R, Semyanov A, Tang Y, Sofroniew MV. PMID: 37828019; PMCID: PMC10570367.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    7. Recovery of walking after paralysis by regenerating characterized neurons to their natural target region. Science. 2023 09 22; 381(6664):1338-1345. Squair JW, Milano M, de Coucy A, Gautier M, Skinnider MA, James ND, Cho N, Lasne A, Kathe C, Hutson TH, Ceto S, Baud L, Galan K, Aureli V, Laskaratos A, Barraud Q, Deming TJ, Kohman RE, Schneider BL, He Z, Bloch J, Sofroniew MV, Courtine G, Anderson MA. PMID: 37733871.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    8. Hyaline protoplasmic astrocytopathy in epilepsy. Neuropathology. 2023 Dec; 43(6):441-456. Magaki S, Haeri M, Szymanski LJ, Chen Z, Diaz R, Williams CK, Chang JW, Ao Y, Newell KL, Khanlou N, Yong WH, Fallah A, Salamon N, Daniel T, Cotter J, Hawes D, Sofroniew M, Vinters HV. PMID: 37198977.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature. 2023 Apr; 616(7956):E6. Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV. PMID: 36977770.
      View in: PubMed   Mentions:    Fields:    
    10. Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin. Nat Commun. 2022 11 02; 13(1):6581. Kim H, Leng K, Park J, Sorets AG, Kim S, Shostak A, Embalabala RJ, Mlouk K, Katdare KA, Rose IVL, Sturgeon SM, Neal EH, Ao Y, Wang S, Sofroniew MV, Brunger JM, McMahon DG, Schrag MS, Kampmann M, Lippmann ES. PMID: 36323693; PMCID: PMC9630454.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    11. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022 11; 25(11):1528-1542. Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. PMID: 36303069; PMCID: PMC9633461.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    12. Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice. Nat Commun. 2022 09 28; 13(1):5702. O'Shea TM, Ao Y, Wang S, Wollenberg AL, Kim JH, Ramos Espinoza RA, Czechanski A, Reinholdt LG, Deming TJ, Sofroniew MV. PMID: 36171203; PMCID: PMC9519954.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    13. Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice. Nat Commun. 2022 07 29; 13(1):4418. Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, Gao K, Potter K, Gilbert HY, Ao Y, Ou J, Fricano-Kugler CJ, Goldberg JL, He Z, Woolf CJ, Sofroniew MV, Benowitz LI, Geschwind DH. PMID: 35906210; PMCID: PMC9338053.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    14. Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature. 2022 06; 606(7914):557-564. Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV. PMID: 35614216; PMCID: PMC10027402.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    15. Correction to: Loss‑of‑function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation. Cell Tissue Res. 2022 May; 388(2):485. Wahane S, Sofroniew MV. PMID: 35366111; PMCID: PMC9035416.
      View in: PubMed   Mentions:    Fields:    
    16. Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age. Nat Commun. 2022 04 04; 13(1):1794. Mills WA, Woo AM, Jiang S, Martin J, Surendran D, Bergstresser M, Kimbrough IF, Eyo UB, Sofroniew MV, Sontheimer H. PMID: 35379828; PMCID: PMC8980042.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    17. Lineage tracing: The gold standard to claim direct reprogramming in vivo. Mol Ther. 2022 03 02; 30(3):988-989. Svendsen CN, Sofroniew MV. PMID: 35123656; PMCID: PMC8899699.
      View in: PubMed   Mentions: 5     Fields:    
    18. Engineering spinal cord repair. Curr Opin Biotechnol. 2021 12; 72:48-53. Squair JW, Gautier M, Sofroniew MV, Courtine G, Anderson MA. PMID: 34695766.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation. Cell Rep. 2021 08 10; 36(6):109508. Diaz-Castro B, Bernstein AM, Coppola G, Sofroniew MV, Khakh BS. PMID: 34380036; PMCID: PMC8418871.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    20. HepaCAM shapes astrocyte territories, stabilizes gap-junction coupling, and influences neuronal excitability. Neuron. 2021 08 04; 109(15):2365-2367. Sofroniew MV. PMID: 34352210.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation. Cell Tissue Res. 2022 Mar; 387(3):337-350. Wahane S, Sofroniew MV. PMID: 34164732; PMCID: PMC8975763.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. PMID: 33589835; PMCID: PMC8007081.
      View in: PubMed   Mentions: 839     Fields:    Translation:HumansAnimalsCells
    23. Meeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research. J Neurotrauma. 2021 05 01; 38(9):1251-1266. Morse LR, Field-Fote EC, Contreras-Vidal J, Noble-Haeusslein LJ, Rodreick M, Shields RK, Sofroniew M, Wudlick R, Zanca JM, SCI 2020 Working Group. PMID: 33353467.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    24. Inflammation drives fibrotic scars in the CNS. Nat Neurosci. 2021 02; 24(2):157-159. Sofroniew MV. PMID: 33526921.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions. Nat Commun. 2020 12 04; 11(1):6203. O'Shea TM, Wollenberg AL, Kim JH, Ao Y, Deming TJ, Sofroniew MV. PMID: 33277474; PMCID: PMC7718896.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    26. Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity. Trends Immunol. 2020 09; 41(9):758-770. Sofroniew MV. PMID: 32819810; PMCID: PMC7484257.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimalsCells
    27. Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma. PLoS One. 2020; 15(7):e0219632. Garrett MC, O'Shea TM, Wollenberg AL, Bernstein AM, Hung D, Staarman B, Soto H, Deming TJ, Sofroniew MV, Kornblum HI. PMID: 32706829; PMCID: PMC7380637.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    28. The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression. Sci Rep. 2019 07 10; 9(1):10010. Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR. PMID: 31292459; PMCID: PMC6620300.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    29. Spinal cord repair: advances in biology and technology. Nat Med. 2019 06; 25(6):898-908. Courtine G, Sofroniew MV. PMID: 31160817.
      View in: PubMed   Mentions: 179     Fields:    Translation:HumansAnimals
    30. Astrocytes usurp neurons as a disease focus. Nat Neurosci. 2019 04; 22(4):512-513. Liddelow SA, Sofroniew MV. PMID: 30858602.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    31. Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP. Cell Stem Cell. 2018 11 01; 23(5):630-631. Sofroniew MV. PMID: 30388417.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018 09; 561(7723):396-400. Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, Kawaguchi R, Coppola G, Wang C, Deming TJ, He Z, Courtine G, Sofroniew MV. PMID: 30158698; PMCID: PMC6151128.
      View in: PubMed   Mentions: 207     Fields:    Translation:AnimalsCells
    33. Dissecting spinal cord regeneration. Nature. 2018 05; 557(7705):343-350. Sofroniew MV. PMID: 29769671.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    34. Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery. Biomaterials. 2018 09; 178:527-545. Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ. PMID: 29657091; PMCID: PMC6054810.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    35. Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):E302-E309. Itoh N, Itoh Y, Tassoni A, Ren E, Kaito M, Ohno A, Ao Y, Farkhondeh V, Johnsonbaugh H, Burda J, Sofroniew MV, Voskuhl RR. PMID: 29279367; PMCID: PMC5777065.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    36. Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation. J Am Chem Soc. 2017 10 25; 139(42):15114-15121. Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ. PMID: 28976744; PMCID: PMC6037417.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    37. Astrocytic tight junctions control inflammatory CNS lesion pathogenesis. J Clin Invest. 2017 Aug 01; 127(8):3136-3151. Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR. PMID: 28737509; PMCID: PMC5531407.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    38. Cell biology of spinal cord injury and repair. J Clin Invest. 2017 Sep 01; 127(9):3259-3270. O'Shea TM, Burda JE, Sofroniew MV. PMID: 28737515; PMCID: PMC5669582.
      View in: PubMed   Mentions: 231     Fields:    Translation:AnimalsCells
    39. Seducing astrocytes to the dark side. Cell Res. 2017 Jun; 27(6):726-727. Burda JE, Sofroniew MV. PMID: 28303889; PMCID: PMC5518868.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    40. Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury. Sci Rep. 2017 01 24; 7:41122. Ren Y, Ao Y, O'Shea TM, Burda JE, Bernstein AM, Brumm AJ, Muthusamy N, Ghashghaei HT, Carmichael ST, Cheng L, Sofroniew MV. PMID: 28117356; PMCID: PMC5259707.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    41. P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. J Neurosci. 2016 08 24; 36(34):8902-20. Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS. PMID: 27559172; PMCID: PMC4995303.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    42. Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016 Apr 14; 532(7598):195-200. Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV. PMID: 27027288; PMCID: PMC5243141.
      View in: PubMed   Mentions: 832     Fields:    Translation:AnimalsCells
    43. Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival. Glia. 2016 May; 64(5):668-94. Levine J, Kwon E, Paez P, Yan W, Czerwieniec G, Loo JA, Sofroniew MV, Wanner IB. PMID: 26683444; PMCID: PMC4805454.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    44. Astrocytes: a central element in neurological diseases. Acta Neuropathol. 2016 Mar; 131(3):323-45. Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A. PMID: 26671410.
      View in: PubMed   Mentions: 362     Fields:    Translation:HumansAnimalsCells
    45. Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13360-5. Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng L, Yang Z, Sun YE, Li X. PMID: 26460053; PMCID: PMC4629389.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    46. Diversity of astrocyte functions and phenotypes in neural circuits. Nat Neurosci. 2015 Jul; 18(7):942-52. Khakh BS, Sofroniew MV. PMID: 26108722; PMCID: PMC5258184.
      View in: PubMed   Mentions: 540     Fields:    Translation:AnimalsCells
    47. Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery. ACS Biomater Sci Eng. 2015 Aug 10; 1(8):705-717. Zhang S, Burda JE, Anderson MA, Zhao Z, Ao Y, Cheng Y, Sun Y, Deming TJ, Sofroniew MV. PMID: 27547820; PMCID: PMC4991036.
      View in: PubMed   Mentions: 16     Fields:    
    48. Astrocyte barriers to neurotoxic inflammation. Nat Rev Neurosci. 2015 May; 16(5):249-63. Sofroniew MV. PMID: 25891508; PMCID: PMC5253239.
      View in: PubMed   Mentions: 537     Fields:    Translation:HumansAnimalsCells
    49. Astrocyte roles in traumatic brain injury. Exp Neurol. 2016 Jan; 275 Pt 3:305-315. Burda JE, Bernstein AM, Sofroniew MV. PMID: 25828533; PMCID: PMC4586307.
      View in: PubMed   Mentions: 349     Fields:    Translation:HumansAnimalsCells
    50. Design and synthesis of nonionic copolypeptide hydrogels with reversible thermoresponsive and tunable physical properties. Biomacromolecules. 2015 Apr 13; 16(4):1331-40. Zhang S, Alvarez DJ, Sofroniew MV, Deming TJ. PMID: 25748800; PMCID: PMC5247266.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    51. Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators. J Vis Exp. 2014 Nov 19; (93):e51972. Jiang R, Haustein MD, Sofroniew MV, Khakh BS. PMID: 25490346; PMCID: PMC4354287.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    52. Astrogliosis. Cold Spring Harb Perspect Biol. 2014 Nov 07; 7(2):a020420. Sofroniew MV. PMID: 25380660; PMCID: PMC4315924.
      View in: PubMed   Mentions: 326     Fields:    Translation:Cells
    53. Glia in the pathogenesis of neurodegenerative diseases. Biochem Soc Trans. 2014 Oct; 42(5):1291-301. Verkhratsky A, Parpura V, Pekna M, Pekny M, Sofroniew M. PMID: 25233406.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    54. Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity. PLoS One. 2014; 9(7):e102003. O'Callaghan JP, Kelly KA, VanGilder RL, Sofroniew MV, Miller DB. PMID: 25025494; PMCID: PMC4098997.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    55. Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Sep 15; 274(1-2):53-61. Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR. PMID: 25005117; PMCID: PMC4343306.
      View in: PubMed   Mentions: 81     Fields:    Translation:AnimalsCells
    56. Memantine enhances recovery from stroke. Stroke. 2014 Jul; 45(7):2093-2100. López-Valdés HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan KC. PMID: 24938836; PMCID: PMC4142682.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    57. Astrocytes and Huntington's disease. ACS Chem Neurosci. 2014 Jul 16; 5(7):494-6. Khakh BS, Sofroniew MV. PMID: 24842291; PMCID: PMC4102957.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    58. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PLoS One. 2014; 9(5):e96318. Assi H, Espinosa J, Suprise S, Sofroniew M, Doherty R, Zamler D, Lowenstein PR, Castro MG. PMID: 24806510; PMCID: PMC4013007.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    59. Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone. Stem Cell Res. 2014 Jul; 13(1):48-60. Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG. PMID: 24835668; PMCID: PMC4096985.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    60. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci. 2014 May; 17(5):694-703. Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS. PMID: 24686787; PMCID: PMC4064471.
      View in: PubMed   Mentions: 303     Fields:    Translation:HumansAnimalsCells
    61. Reactive gliosis and the multicellular response to CNS damage and disease. Neuron. 2014 Jan 22; 81(2):229-48. Burda JE, Sofroniew MV. PMID: 24462092; PMCID: PMC3984950.
      View in: PubMed   Mentions: 640     Fields:    Translation:HumansAnimalsCells
    62. Heterogeneity of reactive astrocytes. Neurosci Lett. 2014 Apr 17; 565:23-9. Anderson MA, Ao Y, Sofroniew MV. PMID: 24361547; PMCID: PMC3984948.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    63. Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system. Biomaterials. 2014 Feb; 35(6):1989-2000. Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV. PMID: 24314556; PMCID: PMC3984939.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    64. Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators. Neuroscientist. 2014 Apr; 20(2):160-72. Sofroniew MV. PMID: 24106265.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
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    66. Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. J Neurosci. 2013 Jun 26; 33(26):10924-33. Spence RD, Wisdom AJ, Cao Y, Hill HM, Mongerson CR, Stapornkul B, Itoh N, Sofroniew MV, Voskuhl RR. PMID: 23804112; PMCID: PMC3693061.
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    67. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J Gen Physiol. 2013 May; 141(5):633-47. Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS. PMID: 23589582; PMCID: PMC3639581.
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    68. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. J Neurosci. 2012 Oct 17; 32(42):14489-510. Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. PMID: 23077035; PMCID: PMC3518872.
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    69. Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots. Biomaterials. 2012 Dec; 33(35):9105-16. Song B, Song J, Zhang S, Anderson MA, Ao Y, Yang CY, Deming TJ, Sofroniew MV. PMID: 22985994.
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    70. STAT3-mediated astrogliosis protects myelin development in neonatal brain injury. Ann Neurol. 2012 Nov; 72(5):750-65. Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA. PMID: 22941903; PMCID: PMC3514566.
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    71. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012 Jul; 122(7):2454-68. Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR. PMID: 22653056; PMCID: PMC3386814.
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    72. Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro. 2012 Apr 05; 4(3). Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodríguez JJ, Nedergaard M. PMID: 22339481; PMCID: PMC3320215.
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    73. Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories. Front Behav Neurosci. 2012; 6:3. Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS. PMID: 22347173; PMCID: PMC3270585.
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    75. Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci. 2011 Jun 01; 31(22):8306-19. Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE. PMID: 21632951; PMCID: PMC3500097.
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    76. Neuroprotection mediated through estrogen receptor-alpha in astrocytes. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8867-72. Spence RD, Hamby ME, Umeda E, Itoh N, Du S, Wisdom AJ, Cao Y, Bondar G, Lam J, Ao Y, Sandoval F, Suriany S, Sofroniew MV, Voskuhl RR. PMID: 21555578; PMCID: PMC3102368.
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    77. Loss of adenomatous polyposis coli in Bergmann glia disrupts their unique architecture and leads to cell nonautonomous neurodegeneration of cerebellar Purkinje neurons. Glia. 2011 Jun; 59(6):857-68. Wang X, Imura T, Sofroniew MV, Fushiki S. PMID: 21381115; PMCID: PMC3287075.
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    78. Neuromyelitis optica: circulating autoantibodies provoke astrocyte-mediated neural dysfunction. Neurology. 2011 Apr 05; 76(14):1202-3. Sofroniew MV. PMID: 21368284.
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    79. Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus. Stem Cells. 2010 Nov; 28(11):2053-2064. Imura T, Wang X, Noda T, Sofroniew MV, Fushiki S. PMID: 21089118; PMCID: PMC4524517.
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    80. Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics. 2010 Oct; 7(4):494-506. Hamby ME, Sofroniew MV. PMID: 20880511; PMCID: PMC2952540.
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    81. Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain. 2010 Oct; 133(10):2999-3016. Crawford DK, Mangiardi M, Song B, Patel R, Du S, Sofroniew MV, Voskuhl RR, Tiwari-Woodruff SK. PMID: 20858739; PMCID: PMC2947430.
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    82. A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nat Neurosci. 2010 Jun; 13(6):759-66. Shigetomi E, Kracun S, Sofroniew MV, Khakh BS. PMID: 20495558; PMCID: PMC2920135.
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    83. Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. PLoS One. 2010 Mar 10; 5(3):e9532. Sarafian TA, Montes C, Imura T, Qi J, Coppola G, Geschwind DH, Sofroniew MV. PMID: 20224768; PMCID: PMC2835741.
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    84. Astrocytes: biology and pathology. Acta Neuropathol. 2010 Jan; 119(1):7-35. Sofroniew MV, Vinters HV. PMID: 20012068; PMCID: PMC2799634.
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    85. PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19479-84. Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H. PMID: 19846776; PMCID: PMC2765459.
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    86. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009 Dec; 32(12):638-47. Sofroniew MV. PMID: 19782411; PMCID: PMC2787735.
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    87. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nat Neurosci. 2009 Oct; 12(10):1333-42. Courtine G, Gerasimenko Y, van den Brand R, Yew A, Musienko P, Zhong H, Song B, Ao Y, Ichiyama RM, Lavrov I, Roy RR, Sofroniew MV, Edgerton VR. PMID: 19767747; PMCID: PMC2828944.
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    88. Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. J Neurosci. 2009 Sep 16; 29(37):11511-22. Voskuhl RR, Peterson RS, Song B, Ao Y, Morales LB, Tiwari-Woodruff S, Sofroniew MV. PMID: 19759299; PMCID: PMC2768309.
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    89. Schwann cell influence on motor neuron regeneration accuracy. Neuroscience. 2009 Sep 29; 163(1):213-21. Madison RD, Sofroniew MV, Robinson GA. PMID: 19505536; PMCID: PMC2728180.
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    90. Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system. Biomaterials. 2009 May; 30(15):2881-98. Yang CY, Song B, Ao Y, Nowak AP, Abelowitz RB, Korsak RA, Havton LA, Deming TJ, Sofroniew MV. PMID: 19251318.
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    91. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11; 29(6):1874-86. Gregorian C, Nakashima J, Le Belle J, Ohab J, Kim R, Liu A, Smith KB, Groszer M, Garcia AD, Sofroniew MV, Carmichael ST, Kornblum HI, Liu X, Wu H. PMID: 19211894; PMCID: PMC2754186.
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    92. STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury. J Neurosci. 2008 Jul 09; 28(28):7231-43. Herrmann JE, Imura T, Song B, Qi J, Ao Y, Nguyen TK, Korsak RA, Takeda K, Akira S, Sofroniew MV. PMID: 18614693; PMCID: PMC2583788.
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    93. Two forms of astrocyte calcium excitability have distinct effects on NMDA receptor-mediated slow inward currents in pyramidal neurons. J Neurosci. 2008 Jun 25; 28(26):6659-63. Shigetomi E, Bowser DN, Sofroniew MV, Khakh BS. PMID: 18579739; PMCID: PMC2866443.
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    94. Glia get excited. Nat Neurosci. 2008 Apr; 11(4):379-80. Otis TS, Sofroniew MV. PMID: 18368040.
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    95. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Exp Neurol. 2008 Jun; 211(2):423-32. Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ. PMID: 18410928; PMCID: PMC9152669.
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    96. Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Nat Med. 2008 Jan; 14(1):69-74. Courtine G, Song B, Roy RR, Zhong H, Herrmann JE, Ao Y, Qi J, Edgerton VR, Sofroniew MV. PMID: 18157143; PMCID: PMC2916740.
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    97. Starring roles for astroglia in barrier pathologies of gut and brain. Lab Invest. 2007 Aug; 87(8):731-6. Savidge TC, Sofroniew MV, Neunlist M. PMID: 17607301.
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    98. Paradoxical influence of hippocampal neurogenesis on working memory. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4642-6. Saxe MD, Malleret G, Vronskaya S, Mendez I, Garcia AD, Sofroniew MV, Kandel ER, Hen R. PMID: 17360577; PMCID: PMC1810330.
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    99. Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology. 2007 Apr; 132(4):1344-58. Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV. PMID: 17408650.
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    101. Essential protective roles of reactive astrocytes in traumatic brain injury. Brain. 2006 Oct; 129(Pt 10):2761-72. Myer DJ, Gurkoff GG, Lee SM, Hovda DA, Sofroniew MV. PMID: 16825202.
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    102. Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes. Glia. 2006 Feb; 53(3):277-93. Imura T, Nakano I, Kornblum HI, Sofroniew MV. PMID: 16267834.
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    103. PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. J Neurosci. 2005 Nov 16; 25(46):10773-85. Dougherty JD, Garcia AD, Nakano I, Livingstone M, Norris B, Polakiewicz R, Wexler EM, Sofroniew MV, Kornblum HI, Geschwind DH. PMID: 16291951; PMCID: PMC6725850.
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    104. Reactive astrocytes in neural repair and protection. Neuroscientist. 2005 Oct; 11(5):400-7. Sofroniew MV. PMID: 16151042.
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    105. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005 Aug 01; 170(3):413-27. Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. PMID: 16061694; PMCID: PMC2171475.
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    106. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci. 2004 Nov; 7(11):1233-41. Garcia AD, Doan NB, Imura T, Bush TG, Sofroniew MV. PMID: 15494728.
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    107. Reactive astrocytes protect tissue and preserve function after spinal cord injury. J Neurosci. 2004 Mar 03; 24(9):2143-55. Faulkner JR, Herrmann JE, Woo MJ, Tansey KE, Doan NB, Sofroniew MV. PMID: 14999065; PMCID: PMC6730429.
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    108. The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci. 2003 Jul; 18(1):76-84. Morshead CM, Garcia AD, Sofroniew MV, van Der Kooy D. PMID: 12859339.
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    109. The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP. J Neurosci. 2003 Apr 01; 23(7):2824-32. Imura T, Kornblum HI, Sofroniew MV. PMID: 12684469; PMCID: PMC6742109.
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    110. Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro. J Cereb Blood Flow Metab. 2001 Aug; 21(8):972-81. Kelly S, Bieneman A, Horsburgh K, Hughes D, Sofroniew MV, McCulloch J, Uney JB. PMID: 11487733.
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    111. Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci. 2001; 24:1217-81. Sofroniew MV, Howe CL, Mobley WC. PMID: 11520933.
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    112. Pituitary adenylate cyclase-activating polypeptide promotes the survival of basal forebrain cholinergic neurons in vitro and in vivo: comparison with effects of nerve growth factor. Eur J Neurosci. 2000 Jul; 12(7):2273-80. Takei N, Torres E, Yuhara A, Jongsma H, Otto C, Korhonen L, Abiru Y, Skoglösa Y, Schütz G, Hatanaka H, Sofroniew MV, Lindholm D. PMID: 10947806.
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    113. Astrocyte failure as a cause of CNS dysfunction. Mol Psychiatry. 2000 May; 5(3):230-2. Sofroniew MV. PMID: 10889520.
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    114. Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice. Brain Res. 1999 Jul 17; 835(1):91-5. Sofroniew MV, Bush TG, Blumauer N, Mucke L, Johnson MH. PMID: 10448200.
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    115. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 1999 Jun; 23(2):297-308. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. PMID: 10399936.
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    116. Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures. Neuroscience. 1999 Mar; 89(2):429-36. Kimonides VG, Spillantini MG, Sofroniew MV, Fawcett JW, Herbert J. PMID: 10077325.
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    117. Re-expression of p75NTR by adult motor neurons after axotomy is triggered by retrograde transport of a positive signal from axons regrowing through damaged or denervated peripheral nerve tissue. Neuroscience. 1999; 91(1):273-81. Bussmann KA, Sofroniew MV. PMID: 10336077.
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    118. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998 Apr 17; 93(2):189-201. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. PMID: 9568712.
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    119. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1852-7. Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. PMID: 9465106; PMCID: PMC19202.
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    120. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci. 1997 Jul 15; 17(14):5549-59. Hinks GL, Shah B, French SJ, Campos LS, Staley K, Hughes J, Sofroniew MV. PMID: 9204936; PMCID: PMC6793804.
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    121. Brain-derived neurotrophic factor, acidic and basic fibroblast growth factors, insulin-like growth factor-I, and various antioxidants do not prevent the apoptotic death of developing septal cholinergic neurons following nerve growth factor withdrawal in vitro. Neuroscience. 1997 Feb; 76(3):809-20. Kew JN, Sofroniew MV. PMID: 9135053.
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    122. Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience. 1996 Nov; 75(1):19-27. De Lacalle S, Cooper JD, Svendsen CN, Dunnett SB, Sofroniew MV. PMID: 8923519.
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    123. Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats. Neuroscience. 1996 Nov; 75(1):29-35. Cooper JD, Sofroniew MV. PMID: 8923520.
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    124. Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat. Exp Neurol. 1996 May; 139(1):143-55. Cooper JD, Skepper JN, Berzaghi MD, Lindholm D, Sofroniew MV. PMID: 8635561.
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    125. Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging? Perspect Dev Neurobiol. 1996; 3(2):133-42. Svendsen CN, Sofroniew MV. PMID: 8826531.
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    126. Nerve growth factor withdrawal induces the apoptotic death of developing septal cholinergic neurons in vitro: protection by cyclic AMP analogue and high potassium. Neuroscience. 1996 Jan; 70(2):329-39. Kew JN, Smith DW, Sofroniew MV. PMID: 8848143.
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    127. Ciliary neurotrophic factor supports p75NGFR-immunoreactive non-cholinergic, but not cholinergic, developing septal neurons in vitro. Neuroscience. 1995 Jun; 66(4):793-804. Kew JN, Sofroniew MV. PMID: 7651610.
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    128. Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats. Neuroscience. 1994 Oct; 62(3):625-9. Cooper JD, Lindholm D, Sofroniew MV. PMID: 7532836.
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    129. Down-regulation of protein kinase C isoform gene expression in degenerating thalamic neurones--lack of induction in reactive glial cells. Biochem Soc Trans. 1994 Aug; 22(3):291S. Wilson VJ, Oddiah D, Sofroniew MV, Panni MK, Rattray M. PMID: 7821550.
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    131. NMDA potentiates NGF-induced sprouting of septal cholinergic fibres. Neuroreport. 1994 Jan 12; 5(4):413-6. Heisenberg CP, Cooper JD, Berke J, Sofroniew MV. PMID: 8003664.
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    132. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 1994 Jan; 14(1):75-87. Svendsen CN, Kew JN, Staley K, Sofroniew MV. PMID: 8283253; PMCID: PMC6576871.
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    133. Atrophy but not death of adult septal cholinergic neurons after ablation of target capacity to produce mRNAs for NGF, BDNF, and NT3. J Neurosci. 1993 Dec; 13(12):5263-76. Sofroniew MV, Cooper JD, Svendsen CN, Crossman P, Ip NY, Lindsay RM, Zafra F, Lindholm D. PMID: 8254373; PMCID: PMC6576406.
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    134. Cholinergic regulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) but not neurotrophin-3 (NT-3) mRNA levels in the developing rat hippocampus. J Neurosci. 1993 Sep; 13(9):3818-26. da Penha Berzaghi M, Cooper J, Castrén E, Zafra F, Sofroniew M, Thoenen H, Lindholm D. PMID: 8366347; PMCID: PMC6576436.
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    135. Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Exp Neurol. 1993 Apr; 120(2):245-63. Broadwell RD, Sofroniew MV. PMID: 8491281.
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    136. Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems. Exp Neurol. 1992 Aug; 117(2):151-75. Isacson O, Sofroniew MV. PMID: 1379936.
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    137. Transgenic modelling of neurodegenerative events gathers momentum. Trends Neurosci. 1991 Dec; 14(12):513-4. Sofroniew MV, Staley K. PMID: 1726340.
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