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Charalabos Pothoulakis

Title(s)Professor, Medicine
SchoolMedicine
Address10945 Le Conte Avenue 2114
Los Angeles CA 90024
Phone3108259104
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    Other Positions
    Title(s)Professor, Pathology and Laboratory Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Decoding Antibiotic-induced Susceptibility to Clostridium difficile Infection
    NIH U01AI124290Aug 20, 2016 - Jul 31, 2021
    Role: Co-Principal Investigator
    Characterization and Targeting of MiR-24 Network in Colitis
    NIH R01DK110003Aug 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    Role of Corticotropin Releasing Hormone in Intestinal Inflammation
    NIH R01DK101671Aug 1, 2015 - Jul 31, 2019
    Role: Principal Investigator
    Barrier Function of the GI Tract in Health and Disease
    NIH P01DK033506Feb 1, 2010 - Sep 29, 2005
    Role: Co-Principal Investigator
    Chronic stress mediates fat-related changes in insulin signaling and gut motility
    NIH RC1DK086150Sep 30, 2009 - Aug 31, 2011
    Role: Co-Principal Investigator
    Toll-like receptors and intestinal inflammation
    NIH R01DK072417Jul 1, 2006 - Jun 30, 2007
    Role: Principal Investigator
    Mechanisms of Neurotensin in Intestinal Inflammation
    NIH R01DK060729Jun 1, 2002 - Aug 31, 2019
    Role: Principal Investigator
    Role of Substance P in Intestinal Inflammation
    NIH R01DK047343Sep 15, 1994 - Dec 31, 1995
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p and MicroRNA-338-3p, are Downregulated in Irritable Bowel Syndrome and are Associated with Barrier Function and MAPK signaling. Gastroenterology. 2021 Feb 19. Mahurkar-Joshi S, Rankin CR, Videlock EJ, Soroosh A, Verma A, Khandadash A, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. PMID: 33617890.
      View in: PubMed   Mentions:    Fields:    
    2. Role and mechanisms of exosomal miRNAs in IBD pathophysiology. Am J Physiol Gastrointest Liver Physiol. 2020 12 01; 319(6):G646-G654. Wani S, Man Law IK, Pothoulakis C. PMID: 33026230.
      View in: PubMed   Mentions:    Fields:    
    3. Therapeutic Mechanism of Macrophage Inflammatory Protein 1 a Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice. J Infect Dis. 2020 Apr 27; 221(10):1623-1635. Wang J, Ortiz C, Fontenot L, Mukhopadhyay R, Xie Y, Chen X, Feng H, Pothoulakis C, Koon HW. PMID: 31793629.
      View in: PubMed   Mentions:    Fields:    
    4. Here to Heal: Mucosal CD74 Signaling in Colitis. Cell Mol Gastroenterol Hepatol. 2020; 10(1):197-198. Hoffman JM, Rankin CR, Pothoulakis C. PMID: 32220559.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. The IBD-associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation. Am J Physiol Gastrointest Liver Physiol. 2020 01 01; 318(1):G34-G40. Rankin CR, Shao L, Elliott J, Rowe L, Patel A, Videlock E, Benhammou JN, Sauk JS, Ather N, Corson M, Alipour O, Gulati A, Pothoulakis C, Padua DM. PMID: 31545920.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. MiR-21 in Substance P-induced exosomes promotes cell proliferation and migration in human colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G802-G810. Bakirtzi K, Man Law IK, Fang K, Iliopoulos D, Pothoulakis C. PMID: 31545921.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. miR-24 Is Elevated in Ulcerative Colitis Patients and Regulates Intestinal Epithelial Barrier Function. Am J Pathol. 2019 09; 189(9):1763-1774. Soroosh A, Rankin CR, Polytarchou C, Lokhandwala ZA, Patel A, Chang L, Pothoulakis C, Iliopoulos D, Padua DM. PMID: 31220450.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation. Life Sci. 2019 Aug 15; 231:116571. Rankin CR, Lokhandwala ZA, Huang R, Pekow J, Pothoulakis C, Padua D. PMID: 31207308.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR. J Vis Exp. 2019 03 01; (145). Rankin CR, Treger J, Faure-Kumar E, Benhammou J, Anisman-Posner D, Bollinger AE, Pothoulakis C, Padua DM. PMID: 30882798.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis. Nat Microbiol. 2019 02; 4(2):269-279. Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, Huang M, Yla-Herttuala S, Moss AC, Paredes-Sabja D, Pothoulakis C, Shah YM, Wang J, Chen X. PMID: 30510170.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Identification of novel mRNAs and lncRNAs associated with mouse experimental colitis and human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G722-G733. Rankin CR, Theodorou E, Man Law IK, Rowe L, Kokkotou E, Pekow J, Wang J, Martín MG, Pothoulakis C, Padua D. PMID: 29953254.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    12. Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol. 2018 07 01; 315(1):G140-G157. Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. PMID: 29565640.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis. Cell Mol Gastroenterol Hepatol. 2018; 6(1):1-16. Hoffman JM, Sideri A, Ruiz JJ, Stavrakis D, Shih DQ, Turner JR, Pothoulakis C, Karagiannides I. PMID: 29928668.
      View in: PubMed   Mentions: 3     Fields:    
    14. Functional role and therapeutic targeting of microRNAs in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2018 02 01; 314(2):G256-G262. Soroosh A, Koutsioumpa M, Pothoulakis C, Iliopoulos D. PMID: 29146677.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. CRHR2/Ucn2 signaling is a novel regulator of miR-7/YY1/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis. Int J Cancer. 2018 01 15; 142(2):334-346. Pothoulakis C, Torre-Rojas M, Duran-Padilla MA, Gevorkian J, Zoras O, Chrysos E, Chalkiadakis G, Baritaki S. PMID: 28929494.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Role of G protein-coupled receptors-microRNA interactions in gastrointestinal pathophysiology. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 01; 313(5):G361-G372. Law IKM, Padua DM, Iliopoulos D, Pothoulakis C. PMID: 28774868.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G610-G623. Koon HW, Su B, Xu C, Mussatto CC, Tran DH, Lee EC, Ortiz C, Wang J, Lee JE, Ho S, Chen X, Kelly CP, Pothoulakis C. PMID: 27514478.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. Am J Physiol Gastrointest Liver Physiol. 2016 09 01; 311(3):G446-57. Padua D, Mahurkar-Joshi S, Law IK, Polytarchou C, Vu JP, Pisegna JR, Shih D, Iliopoulos D, Pothoulakis C. PMID: 27492330.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    19. Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1a-miR-210 Signaling. J Immunol. 2016 05 15; 196(10):4311-21. Bakirtzi K, Law IK, Xue X, Iliopoulos D, Shah YM, Pothoulakis C. PMID: 27076683.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Urocortins and CRF receptor type 2 variants in the male rat colon: gene expression and regulation by endotoxin and anti-inflammatory effect. Am J Physiol Gastrointest Liver Physiol. 2016 Mar 15; 310(6):G387-98. Yuan PQ, Wu SV, Pothoulakis C, Taché Y. PMID: 26744472.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    21. Novel approaches to treating Clostridium difficile-associated colitis. Expert Rev Gastroenterol Hepatol. 2016; 10(2):193-204. Padua D, Pothoulakis C. PMID: 26643655.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis. Am J Pathol. 2016 Jan; 186(1):134-44. Hoffman JM, Baritaki S, Ruiz JJ, Sideri A, Pothoulakis C. PMID: 26597886.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    23. Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):610-630. Rodriguez JA, Huerta-Yepez S, Law IK, Baay-Guzman GJ, Tirado-Rodriguez B, Hoffman JM, Iliopoulos D, Hommes DW, Verspaget HW, Chang L, Pothoulakis C, Baritaki S. PMID: 26495412.
      View in: PubMed   Mentions: 16     Fields:    
    24. Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells. Cell Mol Gastroenterol Hepatol. 2015 Sep 01; 1(5):503-515. Fang K, Sideri A, Law IK, Bakirtzi K, Polytarchou C, Iliopoulos D, Pothoulakis C. PMID: 26645045.
      View in: PubMed   Mentions: 6     Fields:    
    25. Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat. PLoS One. 2015; 10(7):e0130938. Bradesi S, Karagiannides I, Bakirtzi K, Joshi SM, Koukos G, Iliopoulos D, Pothoulakis C, Mayer EA. PMID: 26222740.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients. Cell Mol Gastroenterol Hepatol. 2015 Jul 01; 1(4):420-432. Sideri A, Bakirtzi K, Shih DQ, Koon HW, Fleshner P, Arsenescu R, Arsenescu V, Turner JR, Karagiannides I, Pothoulakis C. PMID: 26543894.
      View in: PubMed   Mentions: 12     Fields:    
    27. MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. Gastroenterology. 2015 Oct; 149(4):981-92.e11. Polytarchou C, Hommes DW, Palumbo T, Hatziapostolou M, Koutsioumpa M, Koukos G, van der Meulen-de Jong AE, Oikonomopoulos A, van Deen WK, Vorvis C, Serebrennikova OB, Birli E, Choi J, Chang L, Anton PA, Tsichlis PN, Pothoulakis C, Verspaget HW, Iliopoulos D. PMID: 26055138.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    28. A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. Inflamm Bowel Dis. 2015 May; 21(5):996-1005. Koukos G, Polytarchou C, Kaplan JL, Oikonomopoulos A, Ziring D, Hommes DW, Wahed R, Kokkotou E, Pothoulakis C, Winter HS, Iliopoulos D. PMID: 25738378.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    29. Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 01; 308(7):G591-604. Sideri A, Stavrakis D, Bowe C, Shih DQ, Fleshner P, Arsenescu V, Arsenescu R, Turner JR, Pothoulakis C, Karagiannides I. PMID: 25591865.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    30. Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis. Cell Mol Gastroenterol Hepatol. 2015 Jan; 1(1):55-74.e1. Yoo JH, Ho S, Tran DH, Cheng M, Bakirtzi K, Kukota Y, Ichikawa R, Su B, Tran DH, Hing TC, Chang I, Shih DQ, Issacson RE, Gallo RL, Fiocchi C, Pothoulakis C, Koon HW. PMID: 25729764.
      View in: PubMed   Mentions: 15     Fields:    
    31. The neurotensin-HIF-1a-VEGFa axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis. Am J Pathol. 2014 Dec; 184(12):3405-14. Bakirtzi K, West G, Fiocchi C, Law IK, Iliopoulos D, Pothoulakis C. PMID: 25307345.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Neurotensin--regulated miR-133a is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis. Gut. 2015 Jul; 64(7):1095-104. Law IK, Bakirtzi K, Polytarchou C, Oikonomopoulos A, Hommes D, Iliopoulos D, Pothoulakis C. PMID: 25112884.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    33. Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats. Physiol Rep. 2014; 2(5):e00284. Karagiannides I, Golovatscka V, Bakirtzi K, Sideri A, Salas M, Stavrakis D, Polytarchou C, Iliopoulos D, Pothoulakis C, Bradesi S. PMID: 24819750.
      View in: PubMed   Mentions: 6     Fields:    
    34. Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice. J Mol Neurosci. 2014 Jan; 52(1):37-47. Vu JP, Million M, Larauche M, Luong L, Norris J, Waschek JA, Pothoulakis C, Pisegna JR, Germano PM. PMID: 24395090.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    35. Silence Please!: siRNA approaches to tighten the intestinal barrier in vivo. Am J Pathol. 2013 Dec; 183(6):1700-1702. Bakirtzi K, Hoffman JM, Pothoulakis C. PMID: 24183845.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    36. MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology. 2013 Oct; 145(4):842-52.e2. Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, Kokkotou E, Baril-Dore M, Pothoulakis C, Winter HS, Iliopoulos D. PMID: 23856509.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    37. Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab. 2013 May 07; 17(5):644-656. Tchkonia T, Thomou T, Zhu Y, Karagiannides I, Pothoulakis C, Jensen MD, Kirkland JL. PMID: 23583168.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansAnimals
    38. Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice. PLoS One. 2013; 8(4):e60939. Tuominen I, Al-Rabadi L, Stavrakis D, Karagiannides I, Pothoulakis C, Bugni JM. PMID: 23560112.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    39. SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS. Eur J Microbiol Immunol (Bp). 2013 Mar; 3(1):11-20. Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. PMID: 23638306.
      View in: PubMed   Mentions:
    40. Antimicrobial peptides and colitis. Curr Pharm Des. 2013; 19(1):40-7. Ho S, Pothoulakis C, Koon HW. PMID: 22950497.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    41. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. PMID: 22760006.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    42. Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by ß-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem. 2012 Apr 27; 287(18):15066-75. Law IK, Murphy JE, Bakirtzi K, Bunnett NW, Pothoulakis C. PMID: 22416137.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    43. Adipose tissue and inflammatory bowel disease pathogenesis. Inflamm Bowel Dis. 2012 Aug; 18(8):1550-7. Fink C, Karagiannides I, Bakirtzi K, Pothoulakis C. PMID: 22407798.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    44. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Therap Adv Gastroenterol. 2012 Mar; 5(2):111-25. Kelesidis T, Pothoulakis C. PMID: 22423260.
      View in: PubMed   Mentions:
    45. Serum and colonic mucosal immune markers in irritable bowel syndrome. Am J Gastroenterol. 2012 Feb; 107(2):262-72. Chang L, Adeyemo M, Karagiannides I, Karagiannidis I, Videlock EJ, Bowe C, Shih W, Presson AP, Yuan PQ, Cortina G, Gong H, Singh S, Licudine A, Mayer M, Tache Y, Pothoulakis C, Mayer EA. PMID: 22158028.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    46. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol. 2012 Feb; 180(2):636-49. Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. PMID: 22138299.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    47. Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways. Endocrinology. 2011 Dec; 152(12):4571-80. Karagiannides I, Bakirtzi K, Kokkotou E, Stavrakis D, Margolis KG, Thomou T, Giorgadze N, Kirkland JL, Pothoulakis C. PMID: 22009727.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    48. The effects of acute and chronic psychological stress on bladder function in a rodent model. Urology. 2011 Oct; 78(4):967.e1-7. Smith AL, Leung J, Kun S, Zhang R, Karagiannides I, Raz S, Lee U, Glovatscka V, Pothoulakis C, Bradesi S, Mayer EA, Rodríguez LV. PMID: 21868072.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    49. Neurotensin signaling activates microRNAs-21 and -155 and Akt, promotes tumor growth in mice, and is increased in human colon tumors. Gastroenterology. 2011 Nov; 141(5):1749-61.e1. Bakirtzi K, Hatziapostolou M, Karagiannides I, Polytarchou C, Jaeger S, Iliopoulos D, Pothoulakis C. PMID: 21806946.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    50. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 2011 Nov; 141(5):1852-63.e1-3. Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C. PMID: 21762664.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    51. Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats. Am J Physiol Gastrointest Liver Physiol. 2011 Sep; 301(3):G580-9. Bradesi S, Golovatscka V, Ennes HS, McRoberts JA, Karagiannides I, Karagiannidis I, Bakirtzi K, Pothoulakis C, Mayer EA. PMID: 21719739.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    52. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. 2011 Jun; 152(6):2197-205. Karagiannides I, Stavrakis D, Bakirtzi K, Kokkotou E, Pirtskhalava T, Nayeb-Hashemi H, Bowe C, Bugni JM, Nuño M, Lu B, Gerard NP, Leeman SE, Kirkland JL, Pothoulakis C. PMID: 21467195.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    53. Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gastroenterology. 2011 May; 140(5):1586-96.e6. Gourcerol G, Wu SV, Yuan PQ, Pham H, Miampamba M, Larauche M, Sanders P, Amano T, Mulak A, Im E, Pothoulakis C, Rivier J, Taché Y, Million M. PMID: 21277852.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    54. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One. 2011 Jan 11; 6(1):e16090. Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR. PMID: 21264313.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    55. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. J Biol Chem. 2011 Feb 25; 286(8):6092-9. Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C. PMID: 21212273.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    56. Neuropeptide - adipose tissue communication and intestinal pathophysiology. Curr Pharm Des. 2011; 17(16):1576-82. Karagiannides I, Bakirtzi K, Pothoulakis C. PMID: 21548874.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    57. Substance P modulates colitis-associated fibrosis. Am J Pathol. 2010 Nov; 177(5):2300-9. Koon HW, Shih D, Karagiannides I, Zhao D, Fazelbhoy Z, Hing T, Xu H, Lu B, Gerard N, Pothoulakis C. PMID: 20889569.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    58. TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem. 2010 Nov 26; 285(48):37570-8. Choi YJ, Im E, Chung HK, Pothoulakis C, Rhee SH. PMID: 20855887.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    59. TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem. 2010 Jul 09; 285(28):21382-90. Choi YJ, Im E, Pothoulakis C, Rhee SH. PMID: 20452988.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    60. Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice. J Nutr. 2009 Oct; 139(10):1848-54. Im E, Choi YJ, Pothoulakis C, Rhee SH. PMID: 19675103.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    61. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology. 2009 Sep; 137(3):914-23. Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou EG, Pothoulakis C, Kelly CP. PMID: 19482027.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    62. Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8766-71. Koon HW, Kim YS, Xu H, Kumar A, Zhao D, Karagiannides I, Dobner PR, Pothoulakis C. PMID: 19443690.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    63. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol. 2009 May; 6(5):306-14. Rhee SH, Pothoulakis C, Mayer EA. PMID: 19404271.
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    64. Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296(5):G1012-9. Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C. PMID: 19282377.
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    65. Substance P, obesity, and gut inflammation. Curr Opin Endocrinol Diabetes Obes. 2009 Feb; 16(1):47-52. Karagiannides I, Pothoulakis C. PMID: 19104238.
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    66. Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress. Gastroenterology. 2009 Apr; 136(4):1339-48, e1-2. Bradesi S, Svensson CI, Steinauer J, Pothoulakis C, Yaksh TL, Mayer EA. PMID: 19249394.
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    67. Neuropeptides, mesenteric fat, and intestinal inflammation. Ann N Y Acad Sci. 2008 Nov; 1144:127-35. Karagiannides I, Pothoulakis C. PMID: 19076372.
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    68. Melanin-concentrating hormone as a mediator of intestinal inflammation. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10613-8. Kokkotou E, Moss AC, Torres D, Karagiannides I, Cheifetz A, Liu S, O'Brien M, Maratos-Flier E, Pothoulakis C. PMID: 18650383.
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    69. Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii. Aliment Pharmacol Ther. 2009 Oct 15; 30(8):826-33. Pothoulakis C. PMID: 19706150.
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    70. Substance P as a novel anti-obesity target. Gastroenterology. 2008 Mar; 134(3):747-55. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. PMID: 18325388.
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    71. Obesity, innate immunity and gut inflammation. Curr Opin Gastroenterol. 2007 Nov; 23(6):661-6. Karagiannides I, Pothoulakis C. PMID: 17906444.
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    72. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37. Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. PMID: 17570216.
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    73. Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E298-307. Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL. PMID: 16985259.
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    74. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006 Aug 25; 281(34):24449-54. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O'Brien M, Pothoulakis C, Kelly CP. PMID: 16816386.
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    75. The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats. Gastroenterology. 2006 May; 130(6):1729-42. Bradesi S, Kokkotou E, Simeonidis S, Patierno S, Ennes HS, Mittal Y, McRoberts JA, Ohning G, McLean P, Marvizon JC, Sternini C, Pothoulakis C, Mayer EA. PMID: 16697737.
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    76. Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5207-12. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C. PMID: 16549770.
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    77. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):69-76. Sougioultzis S, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S, Pothoulakis C, Kelly CP. PMID: 16529714.
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    78. Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia. Am J Physiol Gastrointest Liver Physiol. 2005 Jul; 289(1):G42-53. Bradesi S, Schwetz I, Ennes HS, Lamy CM, Ohning G, Fanselow M, Pothoulakis C, McRoberts JA, Mayer EA. PMID: 15746211.
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    79. Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction. . 2003 Apr; 284(4):C1073-82. Liu TS, Musch MW, Sugi K, Walsh-Reitz MM, Ropeleski MJ, Hendrickson BA, Pothoulakis C, Lamont JT, Chang EB. PMID: 12490434.
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