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Hon Wai Koon

Title(s)Associate Adjunct Professor, Medicine
SchoolMedicine
Address760 Westwood Plaza 1208
Los Angeles CA 90024
Phone3108259104
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice. Sci Rep. 2020 Jul 30; 10(1):12785. Wang J, Ortiz C, Fontenot L, Mukhopadhyay R, Xie Y, Law IKM, Shih DQ, Mattai SA, Li Z, Koon HW. PMID: 32733043.
      View in: PubMed   Mentions:    Fields:    
    2. Therapeutic Mechanism of Macrophage Inflammatory Protein 1 a Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice. J Infect Dis. 2020 Apr 27; 221(10):1623-1635. Wang J, Ortiz C, Fontenot L, Mukhopadhyay R, Xie Y, Chen X, Feng H, Pothoulakis C, Koon HW. PMID: 31793629.
      View in: PubMed   Mentions:    Fields:    
    3. High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures. PLoS One. 2020; 15(4):e0231796. Wang J, Ortiz C, Fontenot L, Xie Y, Ho W, Mattai SA, Shih DQ, Koon HW. PMID: 32287314.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    4. Cathelicidin Suppresses Colon Cancer Metastasis via a P2RX7-Dependent Mechanism. Mol Ther Oncolytics. 2019 Mar 29; 12:195-203. Wang J, Cheng M, Law IKM, Ortiz C, Sun M, Koon HW. PMID: 30847383.
      View in: PubMed   Mentions:
    5. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites. Gastroenterology. 2018 05; 154(6):1737-1750. Wang J, Ghali S, Xu C, Mussatto CC, Ortiz C, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Faull KF, Moller T, Rossetti M, Chen X, Koon HW. PMID: 29360463.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    6. Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-κB Activity. Antimicrob Agents Chemother. 2018 01; 62(1). Koon HW, Wang J, Mussatto CC, Ortiz C, Lee EC, Tran DH, Chen X, Kelly CP, Pothoulakis C. PMID: 29038278.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Sci Rep. 2017 11 27; 7(1):16351. Xu C, Ghali S, Wang J, Shih DQ, Ortiz C, Mussatto CC, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Fleshner P, Robbins L, Vu M, Hing TC, McGovern DPB, Koon HW. PMID: 29180648.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn's disease, and clinical prognosis in inflammatory bowel disease. BMC Gastroenterol. 2017 May 12; 17(1):63. Tran DH, Wang J, Ha C, Ho W, Mattai SA, Oikonomopoulos A, Weiss G, Lacey P, Cheng M, Shieh C, Mussatto CC, Ho S, Hommes D, Koon HW. PMID: 28494754.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    9. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G610-G623. Koon HW, Su B, Xu C, Mussatto CC, Tran DH, Lee EC, Ortiz C, Wang J, Lee JE, Ho S, Chen X, Kelly CP, Pothoulakis C. PMID: 27514478.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. Int J Obes (Lond). 2016 09; 40(9):1424-34. Hoang-Yen Tran D, Hoang-Ngoc Tran D, Mattai SA, Sallam T, Ortiz C, Lee EC, Robbins L, Ho S, Lee JE, Fisseha E, Shieh C, Sideri A, Shih DQ, Fleshner P, McGovern DP, Vu M, Hing TC, Bakirtzi K, Cheng M, Su B, Law I, Karagiannides I, Targan SR, Gallo RL, Li Z, Koon HW. PMID: 27163748.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Substance P mediates pro-inflammatory cytokine release form mesenteric adipocytes in Inflammatory Bowel Disease patients. Cell Mol Gastroenterol Hepatol. 2015 Jul 01; 1(4):420-432. Sideri A, Bakirtzi K, Shih DQ, Koon HW, Fleshner P, Arsenescu R, Arsenescu V, Turner JR, Karagiannides I, Pothoulakis C. PMID: 26543894.
      View in: PubMed   Mentions: 11     Fields:    
    12. Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis. Cell Mol Gastroenterol Hepatol. 2015 Jan; 1(1):55-74.e1. Yoo JH, Ho S, Tran DH, Cheng M, Bakirtzi K, Kukota Y, Ichikawa R, Su B, Tran DH, Hing TC, Chang I, Shih DQ, Issacson RE, Gallo RL, Fiocchi C, Pothoulakis C, Koon HW. PMID: 25729764.
      View in: PubMed   Mentions: 15     Fields:    
    13. Cathelicidin suppresses colon cancer development by inhibition of cancer associated fibroblasts. Clin Exp Gastroenterol. 2015; 8:13-29. Cheng M, Ho S, Yoo JH, Tran DH, Bakirtzi K, Su B, Tran DH, Kubota Y, Ichikawa R, Koon HW. PMID: 25565877.
      View in: PubMed   Mentions:
    14. Endothelin-converting enzyme 1 and ß-arrestins exert spatiotemporal control of substance P-induced inflammatory signals. J Biol Chem. 2014 Jul 18; 289(29):20283-94. Jensen DD, Halls ML, Murphy JE, Canals M, Cattaruzza F, Poole DP, Lieu T, Koon HW, Pothoulakis C, Bunnett NW. PMID: 24898255.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum. Antimicrob Agents Chemother. 2014 Aug; 58(8):4642-50. Koon HW, Ho S, Hing TC, Cheng M, Chen X, Ichikawa Y, Kelly CP, Pothoulakis C. PMID: 24890583.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    16. Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol. 2014 Nov; 7(6):1492-503. Shih DQ, Zheng L, Zhang X, Zhang H, Kanazawa Y, Ichikawa R, Wallace KL, Chen J, Pothoulakis C, Koon HW, Targan SR. PMID: 24850426.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Erratum: Sustained TL1A (TNFSF15) expression on both lymphoid and myeloid cells leads to mild spontaneous intestinal inflammation and fibrosis (DOI: 10.1556/EuJMI.3.2013.1.2). Eur J Microbiol Immunol (Bp). 2013 06; 3(2):141. Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. PMID: 24265931.
      View in: PubMed   Mentions:
    18. Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes. Antimicrob Agents Chemother. 2013 Jul; 57(7):3214-23. Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. PMID: 23629713.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    19. SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS. Eur J Microbiol Immunol (Bp). 2013 Mar; 3(1):11-20. Zheng L, Zhang X, Chen J, Ichikawa R, Wallace K, Pothoulakis C, Koon HW, Targan SR, Shih DQ. PMID: 23638306.
      View in: PubMed   Mentions:
    20. Antimicrobial peptides and colitis. Curr Pharm Des. 2013; 19(1):40-7. Ho S, Pothoulakis C, Koon HW. PMID: 22950497.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    21. Differentiating functional roles of gene expression from immune and non-immune cells in mouse colitis by bone marrow transplantation. J Vis Exp. 2012 Oct 01; (68):e4208. Koon HW, Ho S, Cheng M, Ichikawa R, Pothoulakis C. PMID: 23052552.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. PMID: 22760006.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    23. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol. 2012 Feb; 180(2):636-49. Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ. PMID: 22138299.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    24. Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity. PLoS One. 2011; 6(11):e26994. Leung JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK. PMID: 22096514.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. Substance P induces CCN1 expression via histone deacetylase activity in human colonic epithelial cells. Am J Pathol. 2011 Nov; 179(5):2315-26. Koon HW, Shih DQ, Hing TC, Chen J, Ho S, Zhao D, Targan SR, Pothoulakis C. PMID: 21945803.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology. 2011 Nov; 141(5):1852-63.e1-3. Koon HW, Shih DQ, Chen J, Bakirtzi K, Hing TC, Law I, Ho S, Ichikawa R, Zhao D, Xu H, Gallo R, Dempsey P, Cheng G, Targan SR, Pothoulakis C. PMID: 21762664.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    27. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One. 2011 Jan 11; 6(1):e16090. Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, Song Y, Ko B, Wong MH, Michelsen KS, Martins G, Pothoulakis C, Targan SR. PMID: 21264313.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    28. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. J Biol Chem. 2011 Feb 25; 286(8):6092-9. Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C. PMID: 21212273.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    29. Substance P modulates colitis-associated fibrosis. Am J Pathol. 2010 Nov; 177(5):2300-9. Koon HW, Shih D, Karagiannides I, Zhao D, Fazelbhoy Z, Hing T, Xu H, Lu B, Gerard N, Pothoulakis C. PMID: 20889569.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    30. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology. 2009 Sep; 137(3):914-23. Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou EG, Pothoulakis C, Kelly CP. PMID: 19482027.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    31. Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8766-71. Koon HW, Kim YS, Xu H, Kumar A, Zhao D, Karagiannides I, Dobner PR, Pothoulakis C. PMID: 19443690.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    32. Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296(5):G1012-9. Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C. PMID: 19282377.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    33. Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis. Am J Pathol. 2008 Aug; 173(2):400-10. Koon HW, Zhao D, Xu H, Bowe C, Moss A, Moyer MP, Pothoulakis C. PMID: 18599605.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    34. Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer. 2007 Apr 15; 120(8):1652-6. Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. PMID: 17230532.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    35. Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proc Natl Acad Sci U S A. 2007 Feb 06; 104(6):2013-8. Koon HW, Zhao D, Zhan Y, Moyer MP, Pothoulakis C. PMID: 17264209.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    36. Immunomodulatory properties of substance P: the gastrointestinal system as a model. Ann N Y Acad Sci. 2006 Nov; 1088:23-40. Koon HW, Pothoulakis C. PMID: 17192554.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    37. Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells. J Immunol. 2006 Apr 15; 176(8):5050-9. Koon HW, Zhao D, Zhan Y, Rhee SH, Moyer MP, Pothoulakis C. PMID: 16585602.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    38. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase Cdelta activation. J Pharmacol Exp Ther. 2005 Sep; 314(3):1393-400. Koon HW, Zhao D, Zhan Y, Simeonidis S, Moyer MP, Pothoulakis C. PMID: 15917399.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    39. Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes. Gastroenterology. 2005 Apr; 128(4):1002-11. Na X, Zhao D, Koon HW, Kim H, Husmark J, Moyer MP, Pothoulakis C, LaMont JT. PMID: 15825081.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    40. Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. Mol Pharmacol. 2005 Jun; 67(6):2025-31. Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. PMID: 15755906.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    41. Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes. J Biol Chem. 2004 Oct 29; 279(44):45519-27. Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C. PMID: 15319441.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    42. Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem. 2004 Oct 15; 279(42):43547-54. Zhao D, Zhan Y, Koon HW, Zeng H, Keates S, Moyer MP, Pothoulakis C. PMID: 15247267.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
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