Jonathan P Jacobs

Title(s)Assistant Professor-in-Residence, Medicine
SchoolMedicine
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    Modulation of the Intestinal Microbiome in Obesity by a High Protein Diet
    NIH IK2CX001717Jul 1, 2018 - Jun 30, 2023
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. The Intestinal Microbiome Predicts Weight Loss on a Calorie-Restricted Diet and Is Associated With Improved Hepatic Steatosis. Front Nutr. 2021; 8:718661. Dong TS, Luu K, Lagishetty V, Sedighian F, Woo SL, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot AI, Ye J, Li Z, Pisegna JR, Jacobs JP. PMID: 34307440.
      View in: PubMed   Mentions:
    2. Development of the infant gut microbiome predicts temperament across the first year of life. Dev Psychopathol. 2021 Jun 10; 1-12. Fox M, Lee SM, Wiley KS, Lagishetty V, Sandman CA, Jacobs JP, Glynn LM. PMID: 34108055.
      View in: PubMed   Mentions:    Fields:    
    3. Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome. Front Endocrinol (Lausanne). 2021; 12:667066. Martinez JE, Kahana DD, Ghuman S, Wilson HP, Wilson J, Kim SCJ, Lagishetty V, Jacobs JP, Sinha-Hikim AP, Friedman TC. PMID: 34168615.
      View in: PubMed   Mentions:
    4. Early life adversity predicts brain-gut alterations associated with increased stress and mood. Neurobiol Stress. 2021 Nov; 15:100348. Coley EJL, Mayer EA, Osadchiy V, Chen Z, Subramanyam V, Zhang Y, Hsiao EY, Gao K, Bhatt R, Dong T, Vora P, Naliboff B, Jacobs JP, Gupta A. PMID: 34113697.
      View in: PubMed   Mentions:
    5. Effect of Exclusion Diets on Symptom Severity and the Gut Microbiota in Patients with Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2021 May 19. Lenhart A, Dong T, Joshi S, Jaffe N, Choo C, Liu C, Jacobs JP, Lagishetty V, Shih W, Labus JS, Gupta A, Tillisch K, Mayer EA, Chang L. PMID: 34022450.
      View in: PubMed   Mentions:    Fields:    
    6. Disruption of intestinal barrier and endotoxemia after traumatic brain injury: Implications for post-traumatic epilepsy. Epilepsia. 2021 Jun; 62(6):1472-1481. Mazarati A, Medel-Matus JS, Shin D, Jacobs JP, Sankar R. PMID: 33893636.
      View in: PubMed   Mentions:    Fields:    
    7. The intestinal microbiota as a predictor for antidepressant treatment outcome in geriatric depression: a prospective pilot study. Int Psychogeriatr. 2021 Mar 24; 1-13. Lee SM, Dong TS, Krause-Sorio B, Siddarth P, Milillo MM, Lagishetty V, Datta T, Aguilar-Faustino Y, Jacobs JP, Lavretsky H. PMID: 33757609.
      View in: PubMed   Mentions:    Fields:    
    8. Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration. Neuroimage Clin. 2021; 30:102613. Turkiewicz J, Bhatt RR, Wang H, Vora P, Krause B, Sauk JS, Jacobs JP, Bernstein CN, Kornelsen J, Labus JS, Gupta A, Mayer EA. PMID: 33823388.
      View in: PubMed   Mentions: 1     Fields:    
    9. Specimen Collection and Analysis of the Duodenal Microbiome. J Vis Exp. 2021 01 12; (167). Dreskin BW, Luu K, Dong TS, Benhammou J, Lagishetty V, Vu J, Sanford D, Durazo F, Agopian VG, Jacobs JP, Pisegna JR, Hussain SK. PMID: 33522511.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Understanding the Heterogeneity of Obesity and the Relationship to the Brain-Gut Axis. Nutrients. 2020 Nov 30; 12(12). Hung TKW, Dong TS, Chen Z, Elashoff D, Sinsheimer JS, Jacobs JP, Lagishetty V, Vora P, Stains J, Mayer EA, Gupta A. PMID: 33266058.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Shifts in microbial diversity, composition, and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys. Microbiome. 2020 11 06; 8(1):154. Jasinska AJ, Dong TS, Lagishetty V, Katzka W, Jacobs JP, Schmitt CA, Cramer JD, Ma D, Coetzer WG, Grobler JP, Turner TR, Freimer N, Pandrea I, Apetrei C. PMID: 33158452.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Analysis of brain networks and fecal metabolites reveals brain-gut alterations in premenopausal females with irritable bowel syndrome. Transl Psychiatry. 2020 11 02; 10(1):367. Osadchiy V, Mayer EA, Gao K, Labus JS, Naliboff B, Tillisch K, Chang L, Jacobs JP, Hsiao EY, Gupta A. PMID: 33139708.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science. 2020 10 23; 370(6515):467-472. Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. PMID: 33093110.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity. Nutrients. 2020 Oct 21; 12(10). Dong TS, Luu K, Lagishetty V, Sedighian F, Woo SL, Dreskin BW, Katzka W, Chang C, Zhou Y, Arias-Jayo N, Yang J, Ahdoot A, Li Z, Pisegna JR, Jacobs JP. PMID: 33096810.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    15. Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain-Gut-Microbiome Axis in Obese Women. Nutrients. 2020 Sep 24; 12(10). Dong TS, Gupta A, Jacobs JP, Lagishetty V, Gallagher E, Bhatt RR, Vora P, Osadchiy V, Stains J, Balioukova A, Chen Y, Dutson E, Mayer EA, Sanmiguel C. PMID: 32987837.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. A Distinct Brain-Gut-Microbiome Profile Exists for Females with Obesity and Food Addiction. Obesity (Silver Spring). 2020 08; 28(8):1477-1486. Dong TS, Mayer EA, Osadchiy V, Chang C, Katzka W, Lagishetty V, Gonzalez K, Kalani A, Stains J, Jacobs JP, Longo VD, Gupta A. PMID: 32935533.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis. Nutrients. 2020 May 13; 12(5). Hussain SK, Dong TS, Agopian V, Pisegna JR, Durazo FA, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Ayoub WS, Lagishetty V, Elashoff D, Goodman MT, Jacobs JP. PMID: 32414035.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. A Microbial Signature Identifies Advanced Fibrosis in Patients with Chronic Liver Disease Mainly Due to NAFLD. Sci Rep. 2020 02 17; 10(1):2771. Dong TS, Katzka W, Lagishetty V, Luu K, Hauer M, Pisegna J, Jacobs JP. PMID: 32066758.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Gastrointestinal symptoms are predictive of trajectories of cognitive functioning in de novo Parkinson's disease. Parkinsonism Relat Disord. 2020 03; 72:7-12. Jones JD, Rahmani E, Garcia E, Jacobs JP. PMID: 32058266.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Metformin alters the duodenal microbiome and decreases the incidence of pancreatic ductal adenocarcinoma promoted by diet-induced obesity. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G763-G772. Dong TS, Chang HH, Hauer M, Lagishetty V, Katzka W, Rozengurt E, Jacobs JP, Eibl G. PMID: 31545922.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    21. Microbial Profiles of Cirrhosis in the Human Small Intestine. Curr Gastroenterol Rep. 2019 Aug 23; 21(10):50. Dong TS, Jacobs JP, Hussain SK. PMID: 31444636.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome. Nutrients. 2019 Aug 14; 11(8). Hakimian JK, Dong TS, Barahona JA, Lagishetty V, Tiwari S, Azani D, Barrera M, Lee S, Severino AL, Mittal N, Cahill CM, Jacobs JP, Walwyn WM. PMID: 31416242.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Psychobiotics: Shaping the Mind With Gut Bacteria. Am J Gastroenterol. 2019 07; 114(7):1034-1035. Jacobs JP, Mayer EA. PMID: 31268916.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Nonalcoholic fatty liver disease and the gut microbiome: Are bacteria responsible for fatty liver? Exp Biol Med (Maywood). 2019 04; 244(6):408-418. Dong TS, Jacobs JP. PMID: 30871368.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    25. Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and ROR?t+ Regulatory T Cells and Exacerbate Colitis in Mice. Immunity. 2019 01 15; 50(1):212-224.e4. Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ. PMID: 30650377.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    26. Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study. Hepatol Res. 2018 Dec; 48(13):1108-1117. Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, Ayoub WS, Durazo F, Benhammou J, Enayati P, Elashoff D, Goodman MT, Pisegna J, Hussain S. PMID: 29923681.
      View in: PubMed   Mentions:
    27. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 2018 09; 11(5):1466-1476. Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. PMID: 29988118.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites. Gastroenterology. 2018 05; 154(6):1737-1750. Wang J, Ghali S, Xu C, Mussatto CC, Ortiz C, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Faull KF, Moller T, Rossetti M, Chen X, Koon HW. PMID: 29360463.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    29. CSA13 inhibits colitis-associated intestinal fibrosis via a formyl peptide receptor like-1 mediated HMG-CoA reductase pathway. Sci Rep. 2017 11 27; 7(1):16351. Xu C, Ghali S, Wang J, Shih DQ, Ortiz C, Mussatto CC, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Fleshner P, Robbins L, Vu M, Hing TC, McGovern DPB, Koon HW. PMID: 29180648.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. High-protein diet improves sensitivity to cholecystokinin and shifts the cecal microbiome without altering brain inflammation in diet-induced obesity in rats. . 2017 Oct 01; 313(4):R473-R486. Wang L, Jacobs JP, Lagishetty V, Yuan PQ, Wu SV, Million M, Reeve JR, Pisegna JR, Taché Y. PMID: 28724546.
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    31. Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts. BMJ Open Gastroenterol. 2017; 4(1):e000134. Volkmann ER, Hoffmann-Vold AM, Chang YL, Jacobs JP, Tillisch K, Mayer EA, Clements PJ, Hov JR, Kummen M, Midtvedt Ø, Lagishetty V, Chang L, Labus JS, Molberg Ø, Braun J. PMID: 28761687.
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    32. Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex. J Neurogastroenterol Motil. 2017 Jan 30; 23(1):135-143. Moussaoui N, Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y. PMID: 27829577.
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    33. Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes. 2017 01 02; 8(1):1-16. Jacobs JP, Lin L, Goudarzi M, Ruegger P, McGovern DP, Fornace AJ, Borneman J, Xia L, Braun J. PMID: 27874308.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis. Radiat Res. 2016 09; 186(3):219-34. Goudarzi M, Mak TD, Jacobs JP, Moon BH, Strawn SJ, Braun J, Brenner DJ, Fornace AJ, Li HH. PMID: 27512828.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsPHPublic Health
    35. A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition. Gastroenterology. 2016 10; 151(4):724-32. Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH. PMID: 27492617.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    36. A Disease-Associated Microbial and Metabolomics State in Relatives of Pediatric Inflammatory Bowel Disease Patients. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):750-766. Jacobs JP, Goudarzi M, Singh N, Tong M, McHardy IH, Ruegger P, Asadourian M, Moon BH, Ayson A, Borneman J, McGovern DP, Fornace AJ, Braun J, Dubinsky M. PMID: 28174747.
      View in: PubMed   Mentions: 36     Fields:    
    37. Association of Systemic Sclerosis With a Unique Colonic Microbial Consortium. Arthritis Rheumatol. 2016 06; 68(6):1483-92. Volkmann ER, Chang YL, Barroso N, Furst DE, Clements PJ, Gorn AH, Roth BE, Conklin JL, Getzug T, Borneman J, McGovern DP, Tong M, Jacobs JP, Braun J. PMID: 26749064.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    38. Sampling of intestinal microbiota and targeted amplification of bacterial 16S rRNA genes for microbial ecologic analysis. Curr Protoc Immunol. 2014 Nov 03; 107:7.41.1-7.41.11. Tong M, Jacobs JP, McHardy IH, Braun J. PMID: 25367129.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    39. Immune and genetic gardening of the intestinal microbiome. FEBS Lett. 2014 Nov 17; 588(22):4102-11. Jacobs JP, Braun J. PMID: 24613921.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    40. Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum. 2010 Jul; 62(7):1921-32. Jacobs JP, Ortiz-Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C. PMID: 20506316.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    41. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21789-94. Jacobs JP, Wu HJ, Benoist C, Mathis D. PMID: 19955422.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    42. Circulating C3 is necessary and sufficient for induction of autoantibody-mediated arthritis in a mouse model. Arthritis Rheum. 2007 Sep; 56(9):2968-74. Monach PA, Verschoor A, Jacobs JP, Carroll MC, Wagers AJ, Benoist C, Mathis D. PMID: 17763447.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    43. Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94. Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C. PMID: 15334485.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. Management of glucocorticoid-induced osteoporosis in patients with rheumatoid arthritis: rates and predictors of care in an academic rheumatology practice. Arthritis Rheum. 2002 Dec; 46(12):3136-42. Solomon DH, Katz JN, Jacobs JP, La Tourette AM, Coblyn J. PMID: 12483716.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
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