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Mazarati, Andrey Mironovich

Title(s)Adjunct Professor, Pediatrics
SchoolPeds - Neurology
Phone3102065198
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of comorbidity between epilepsy and depression
    NIH/NINDS R01NS065783Aug 15, 2014 - Apr 30, 2018
    Role: Principal Investigator
    Optogenetic treatment of epilepsyassociated
    NIH/NINDS R21NS089396Jul 1, 2014 - Jun 30, 2016
    Role: Co-Principal Investigator
    Neurobiological basis of Depression as a Comorbidity in Epilepsy
    NIH/NIMH R21MH079933Apr 20, 2009 - Mar 31, 2012
    Role: Principal Investigator
    Validation of High-Throughput Screening of Candidate Antiepileptogenic Drugs
    NIH/NINDS R21NS059505Feb 15, 2008 - Jul 31, 2011
    Role: Principal Investigator
    BRAIN GALANIN RECEPTORS AND EPILEPSY
    NIH/NINDS R01NS043409Dec 1, 2002 - Nov 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mazarati A. Can we and should we use animal models to study neurobehavioral comorbidities of epilepsy? Epilepsy Behav. 2019 Dec; 101(Pt A):106566. PMID: 31699663.
      View in: PubMed
    2. Minakova E, Lang J, Medel-Matus JS, Gould GG, Reynolds A, Shin D, Mazarati A, Sankar R. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS One. 2019; 14(1):e0210389. PMID: 30629642.
      View in: PubMed
    3. Mazarati A, Jones NC, Galanopoulou AS, Harte-Hargrove LC, Kalynchuk LE, Lenck-Santini PP, Medel-Matus JS, Nehlig A, de la Prida LM, Sarkisova K, Veliskova J. A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force. Epilepsia Open. 2018 Nov; 3(Suppl Suppl 1):24-52. PMID: 30450484.
      View in: PubMed
    4. Mazarati A, Galanopoulou AS. Commentary on Li et al. "Disrupted female estrous cyclicity in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy". Epilepsia Open. 2018 Jun; 3(2):131-133. PMID: 29881794.
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    5. Medel-Matus JS, Shin D, Dorfman E, Sankar R, Mazarati A. Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome. Epilepsia Open. 2018 Jun; 3(2):290-294. PMID: 29881810.
      View in: PubMed
    6. Medel-Matus JS, Shin D, Sankar R, Mazarati A. Kindling epileptogenesis and panic-like behavior: Their bidirectional connection and contribution to epilepsy-associated depression. Epilepsy Behav. 2017 12; 77:33-38. PMID: 29107199.
      View in: PubMed
    7. Mazarati AM, Lewis ML, Pittman QJ. Neurobehavioral comorbidities of epilepsy: Role of inflammation. Epilepsia. 2017 07; 58 Suppl 3:48-56. PMID: 28675557.
      View in: PubMed
    8. Medel-Matus JS, Reynolds A, Shin D, Sankar R, Mazarati A. Regulation of kindling epileptogenesis by hippocampal Toll-like receptors 2. Epilepsia. 2017 08; 58(8):e122-e126. PMID: 28632301.
      View in: PubMed
    9. Medel-Matus JS, Shin D, Sankar R, Mazarati A. Inherent vulnerabilities in monoaminergic pathways predict the emergence of depressive impairments in an animal model of chronic epilepsy. Epilepsia. 2017 08; 58(8):e116-e121. PMID: 28597913.
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    10. Dai Y, Zhao Y, Tomi M, Shin BC, Thamotharan S, Mazarati A, Sankar R, Wang EA, Cepeda C, Levine MS, Zhang J, Frew A, Alger JR, Clark PM, Sondhi M, Kositamongkol S, Leibovitch L, Devaskar SU. Sex-Specific Life Course Changes in the Neuro-Metabolic Phenotype of Glut3 Null Heterozygous Mice: Ketogenic Diet Ameliorates Electroencephalographic Seizures and Improves Sociability. Endocrinology. 2017 04 01; 158(4):936-949. PMID: 28324109.
      View in: PubMed
    11. Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. 2017 03; 58(3):331-342. PMID: 28035782.
      View in: PubMed
    12. Medel-Matus JS, Shin D, Sankar R, Mazarati A. Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy. Exp Neurol. 2017 03; 289:64-72. PMID: 28013000.
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    13. Dupuis N, Mazarati A, Desnous B, Chhor V, Fleiss B, Le Charpentier T, Lebon S, Csaba Z, Gressens P, Dournaud P, Auvin S. Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains. J Neuroinflammation. 2016 12 12; 13(1):307. PMID: 27955671.
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    14. Mazarati A, Sankar R. Common Mechanisms Underlying Epileptogenesis and the Comorbidities of Epilepsy. Cold Spring Harb Perspect Med. 2016 07 01; 6(7). PMID: 27371669.
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    15. Caplan R, Mefford H, Berl M, Chang B, Lin J, Mazarati A, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions. Epilepsy Curr. 2016 May-Jun; 16(3):182-6. PMID: 27330450.
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    16. Kumar U, Medel-Matus JS, Redwine HM, Shin D, Hensler JG, Sankar R, Mazarati A. Effects of selective serotonin and norepinephrine reuptake inhibitors on depressive- and impulsive-like behaviors and on monoamine transmission in experimental temporal lobe epilepsy. Epilepsia. 2016 Mar; 57(3):506-15. PMID: 26813337.
      View in: PubMed
    17. Hagen E, Shprung D, Minakova E, Washington J, Kumar U, Shin D, Sankar R, Mazarati A. Autism-Like Behavior in BTBR Mice Is Improved by Electroconvulsive Therapy. Neurotherapeutics. 2015 Jul; 12(3):657-66. PMID: 25916397.
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    18. Washington J, Kumar U, Medel-Matus JS, Shin D, Sankar R, Mazarati A. Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice. Epilepsy Behav. 2015 Sep; 50:40-5. PMID: 26103532.
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    19. Mazarati A. Behavioral and neuroendocrine assays for studying epilepsy-associated depression. Epilepsia. 2013 Dec; 54(12):2229. PMID: 24304441.
      View in: PubMed
    20. Pineda E, Jentsch JD, Shin D, Griesbach G, Sankar R, Mazarati A. Behavioral impairments in rats with chronic epilepsy suggest comorbidity between epilepsy and attention deficit/hyperactivity disorder. Epilepsy Behav. 2014 Feb; 31:267-75. PMID: 24262783.
      View in: PubMed
    21. Kwon YS, Pineda E, Auvin S, Shin D, Mazarati A, Sankar R. Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain. J Neuroinflammation. 2013 Feb 26; 10:30. PMID: 23442201.
      View in: PubMed
    22. Auvin S, Pineda E, Shin D, Gressens P, Mazarati A. Novel animal models of pediatric epilepsy. Neurotherapeutics. 2012 Apr; 9(2):245-61. PMID: 22467296.
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    23. Vezzani A, Aronica E, Mazarati A, Pittman QJ. Epilepsy and brain inflammation. Exp Neurol. 2013 Jun; 244:11-21. PMID: 21985866.
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    24. Mazarati A, Maroso M, Iori V, Vezzani A, Carli M. High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products. Exp Neurol. 2011 Dec; 232(2):143-8. PMID: 21884699.
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    25. Sankar R, Mazarati A. Neurobiology of Depression as a Comorbidity of Epilepsy. Epilepsia. 2010 Dec; 51(s5):81. PMID: 21415938.
      View in: PubMed
    26. Auvin S, Shin D, Mazarati A, Sankar R. Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA. Epilepsia. 2010 Jul; 51 Suppl 3:34-8. PMID: 20618397.
      View in: PubMed
    27. Pineda E, Shin D, Sankar R, Mazarati AM. Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms. Epilepsia. 2010 Jul; 51 Suppl 3:110-4. PMID: 20618414.
      View in: PubMed
    28. Auvin S, Mazarati A, Shin D, Sankar R. Inflammation enhances epileptogenesis in the developing rat brain. Neurobiol Dis. 2010 Oct; 40(1):303-10. PMID: 20600912.
      View in: PubMed
    29. Mazarati AM, Pineda E, Shin D, Tio D, Taylor AN, Sankar R. Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta. Neurobiol Dis. 2010 Feb; 37(2):461-7. PMID: 19900553.
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    30. Fenoglio-Simeone K, Mazarati A, Sefidvash-Hockley S, Shin D, Wilke J, Milligan H, Sankar R, Rho JM, Maganti R. Anticonvulsant effects of the selective melatonin receptor agonist ramelteon. Epilepsy Behav. 2009 Sep; 16(1):52-7. PMID: 19682955.
      View in: PubMed
    31. Mazarati AM, Shin D, Kwon YS, Bragin A, Pineda E, Tio D, Taylor AN, Sankar R. Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. Neurobiol Dis. 2009 Jun; 34(3):457-61. PMID: 19285131.
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    32. Mazarati A, Shin D, Sankar R. Bumetanide inhibits rapid kindling in neonatal rats. Epilepsia. 2009 Sep; 50(9):2117-22. PMID: 19260939.
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    33. Mazarati A, Siddarth P, Baldwin RA, Shin D, Caplan R, Sankar R. Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. Brain. 2008 Aug; 131(Pt 8):2071-83. PMID: 18559371.
      View in: PubMed
    34. Mazarati A, Wu J, Shin D, Kwon YS, Sankar R. Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study. Epilepsia. 2008 Oct; 49(10):1777-86. PMID: 18503560.
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    35. Mazarati A, Shin D, Auvin S, Caplan R, Sankar R. Kindling epileptogenesis in immature rats leads to persistent depressive behavior. Epilepsy Behav. 2007 May; 10(3):377-83. PMID: 17368107.
      View in: PubMed
    36. Sankar R, Auvin S, Shin D, Mazarati A. Inflammation modifies status epilepticus-induced hippocampal injury during development. Epilepsia. 2007; 48 Suppl 8:16-8. PMID: 18329988.
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    37. Auvin S, Shin D, Mazarati A, Nakagawa J, Miyamoto J, Sankar R. Inflammation exacerbates seizure-induced injury in the immature brain. Epilepsia. 2007; 48 Suppl 5:27-34. PMID: 17910578.
      View in: PubMed
    38. Mazarati A. Virus-induced injury of the dentate gyrus: deconstructing the gate in the way of seizures. Epilepsy Curr. 2006 Jul-Aug; 6(4):128-9. PMID: 17260034.
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    39. Mazarati A, Lundström L, Sollenberg U, Shin D, Langel U, Sankar R. Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. J Pharmacol Exp Ther. 2006 Aug; 318(2):700-8. PMID: 16699066.
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    40. Mazarati A, Sankar R. Status epilepticus: Danse Macabre in a ballet of subunits. Epilepsy Curr. 2006 May-Jun; 6(3):102-5. PMID: 16761075.
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    41. Auvin S, Shin D, Mazarati A, Sankar R. The utility of testing pentylenetetrazol threshold. Epilepsia. 2006 Mar; 47(3):662-3; author reply 663-4. PMID: 16529641.
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    42. Florén A, Sollenberg U, Lundström L, Zorko M, Stojan J, Budihna M, Wheatley M, Martin NP, Kilk K, Mazarati A, Bartfai T, Lindgren M, Langel U. Multiple interaction sites of galnon trigger its biological effects. Neuropeptides. 2005 Dec; 39(6):547-58. PMID: 16297447.
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    43. Mazarati AM, Baldwin RA, Shinmei S, Sankar R. In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures. J Neurochem. 2005 Dec; 95(5):1495-503. PMID: 16219029.
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    44. Mazarati A, Lu X. Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors. Neuropeptides. 2005 Jun; 39(3):277-80. PMID: 15944022.
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    45. Lu X, Mazarati A, Sanna P, Shinmei S, Bartfai T. Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity. Neuropeptides. 2005 Jun; 39(3):147-52. PMID: 15944003.
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    46. Mazarati AM. Galanin and galanin receptors in epilepsy. Neuropeptides. 2004 Dec; 38(6):331-43. PMID: 15567469.
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    47. Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10470-5. PMID: 15240875.
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    48. Mazarati A, Lu X, Kilk K, Langel U, Wasterlain C, Bartfai T. Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus. Eur J Neurosci. 2004 Jun; 19(12):3235-44. PMID: 15217380.
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    49. Mazarati AM, Baldwin R, Klitgaard H, Matagne A, Wasterlain CG. Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res. 2004 Feb; 58(2-3):167-74. PMID: 15120747.
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    50. Mazarati A, Lu X, Shinmei S, Badie-Mahdavi H, Bartfai T. Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice. Neuroscience. 2004; 128(2):431-41. PMID: 15350653.
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    51. Mazarati A, Wasterlain CG. Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus. Neurosci Lett. 2002 Oct 11; 331(2):123-7. PMID: 12361856.
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    52. Mazarati AM, Sofia RD, Wasterlain CG. Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus. Seizure. 2002 Oct; 11(7):423-30. PMID: 12237067.
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    53. Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7136-41. PMID: 12011470.
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    54. Mazarati A, Bragin A, Baldwin R, Shin D, Wilson C, Sankar R, Naylor D, Engel J, Wasterlain CG. Epileptogenesis after self-sustaining status epilepticus. Epilepsia. 2002; 43 Suppl 5:74-80. PMID: 12121299.
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    55. Wasterlain CG, Mazarati AM, Naylor D, Niquet J, Liu H, Suchomelova L, Baldwin R, Katsumori H, Shirasaka Y, Shin D, Sankar R. Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus. Epilepsia. 2002; 43 Suppl 5:20-9. PMID: 12121290.
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    56. Sankar R, Shin D, Liu H, Wasterlain C, Mazarati A. Epileptogenesis during development: injury, circuit recruitment, and plasticity. Epilepsia. 2002; 43 Suppl 5:47-53. PMID: 12121295.
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    57. Wasterlain CG, Niquet J, Thompson KW, Baldwin R, Liu H, Sankar R, Mazarati AM, Naylor D, Katsumori H, Suchomelova L, Shirasaka Y. Seizure-induced neuronal death in the immature brain. Prog Brain Res. 2002; 135:335-53. PMID: 12143353.
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    58. Mazarati A, Langel U, Bartfai T. Galanin: an endogenous anticonvulsant? Neuroscientist. 2001 Dec; 7(6):506-17. PMID: 11765128.
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    59. Mazarati AM, Baldwin RA, Sofia RD, Wasterain CG. Felbamate in experimental model of status epilepticus. Epilepsia. 2000 Feb; 41(2):123-7. PMID: 10691107.
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    60. Mazarati AM, Wasterlain CG. N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat. Neurosci Lett. 1999 Apr 23; 265(3):187-90. PMID: 10327162.
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    61. Mazarati AM, Wasterlain CG, Sankar R, Shin D. Self-sustaining status epilepticus after brief electrical stimulation of the perforant path. Brain Res. 1998 Aug 10; 801(1-2):251-3. PMID: 9729413.
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    62. Mazarati AM, Wasterlain CG. Blockers of NMDA receptor restore paired-pulse inhibition in the rat dentate gyrus lesioned by perforant path stimulation. Neurosci Lett. 1997 Oct 03; 234(2-3):135-8. PMID: 9364516.
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    63. Mazarati AM, Wasterlain CG. Selective facilitation of kindled seizures from the amygdala after hippocampal lesions induced by perforant path stimulation. Neurosci Lett. 1997 Mar 21; 224(3):165-8. PMID: 9131662.
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