Loading...

Richard Joseph Staba

Title(s)Professor-in-Residence, Neurology
SchoolMedicine
Phone58479
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Defining the Epileptogenic Network and Identifying which Components Generate Seizures
    NIH/NINDS R01NS106957Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Mapping Cortical Anatomical and Electrophysiological Abnormalities in Human MTLE
    NIH/NINDS R01NS071048Feb 1, 2011 - Jan 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Weiss SA, Song I, Leng M, Pastore T, Slezak D, Waldman Z, Orosz I, Gorniak R, Donmez M, Sharan A, Wu C, Fried I, Sperling MR, Bragin A, Engel J, Nir Y, Staba R. Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus. Front Neurol. 2020; 11:174. PMID: 32292384.
      View in: PubMed
    2. Stacey W, Kramer M, Gunnarsdottir K, Gonzalez-Martinez J, Zaghloul K, Inati S, Sarma S, Stiso J, Khambhati AN, Bassett DS, Smith RJ, Liu VB, Lopour BA, Staba R. Emerging roles of network analysis for epilepsy. Epilepsy Res. 2020 Jan; 159:106255. PMID: 31855828.
      View in: PubMed
    3. Weiss SA, Waldman Z, Raimondo F, Slezak D, Donmez M, Worrell G, Bragin A, Engel J, Staba R, Sperling M. Localizing epileptogenic regions using high-frequency oscillations and machine learning. Biomark Med. 2019 04; 13(5):409-418. PMID: 31044598.
      View in: PubMed
    4. Casillas-Espinosa PM, Andrade P, Santana-Gomez C, Paananen T, Smith G, Ali I, Ciszek R, Ndode-Ekane XE, Brady RD, Tohka J, Hudson MR, Perucca P, Braine EL, Immonen R, Puhakka N, Shultz SR, Jones NC, Staba RJ, Pitkänen A, O'Brien TJ. Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis. Epilepsy Res. 2019 Oct; 156:106131. PMID: 31076256.
      View in: PubMed
    5. Li L, Bragin A, Staba R, Engel J. Unit firing and oscillations at seizure onset in epileptic rodents. Neurobiol Dis. 2019 07; 127:382-389. PMID: 30928646.
      View in: PubMed
    6. Santana-Gomez C, Andrade P, Hudson MR, Paananen T, Ciszek R, Smith G, Ali I, Rundle BK, Ndode-Ekane XE, Casillas-Espinosa PM, Immonen R, Puhakka N, Jones N, Brady RD, Perucca P, Shultz SR, Pitkänen A, O'Brien TJ, Staba R. Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis. Epilepsy Res. 2019 Oct; 156:106110. PMID: 30981541.
      View in: PubMed
    7. Ndode-Ekane XE, Santana-Gomez C, Casillas-Espinosa PM, Ali I, Brady RD, Smith G, Andrade P, Immonen R, Puhakka N, Hudson MR, Braine EL, Shultz SR, Staba RJ, O'Brien TJ, Pitkänen A. Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis. Epilepsy Res. 2019 03; 151:7-16. PMID: 30711714.
      View in: PubMed
    8. Pitkänen A, O'Brien TJ, Staba R. Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium. Epilepsy Res. 2019 Oct; 156:106080. PMID: 30685321.
      View in: PubMed
    9. Immonen R, Smith G, Brady RD, Wright D, Johnston L, Harris NG, Manninen E, Salo R, Branch C, Duncan D, Cabeen R, Ndode-Ekane XE, Gomez CS, Casillas-Espinosa PM, Ali I, Shultz SR, Andrade P, Puhakka N, Staba RJ, O'Brien TJ, Toga AW, Pitkänen A, Gröhn O. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis. Epilepsy Res. 2019 02; 150:46-57. PMID: 30641351.
      View in: PubMed
    10. Ciszek R, Ndode-Ekane XE, Gomez CS, Casillas-Espinosa PM, Ali I, Smith G, Puhakka N, Lapinlampi N, Andrade P, Kamnaksh A, Immonen R, Paananen T, Hudson MR, Brady RD, Shultz SR, O'Brien TJ, Staba RJ, Tohka J, Pitkänen A. Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis. Epilepsy Res. 2019 02; 150:17-26. PMID: 30605864.
      View in: PubMed
    11. Kamnaksh A, Puhakka N, Ali I, Smith G, Aniceto R, McCullough J, Das Gupta S, Ndode-Ekane XE, Brady R, Casillas-Espinosa P, Hudson M, Santana-Gomez C, Immonen R, Abreu PA, Jones N, Shultz S, Staba RJ, O'Brien TJ, Agoston D, Pitkänen A. Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis. Epilepsy Res. 2019 01; 149:92-101. PMID: 30553097.
      View in: PubMed
    12. Weiss SA, Staba R, Bragin A, Moxon K, Sperling M, Avoli M, Engel J. "Interneurons and principal cell firing in human limbic areas at focal seizure onset". Neurobiol Dis. 2019 04; 124:183-188. PMID: 30471414.
      View in: PubMed
    13. Elahian B, Lado NE, Mankin E, Vangala S, Misra A, Moxon K, Fried I, Sharan A, Yeasin M, Staba R, Bragin A, Avoli M, Sperling MR, Engel J, Weiss SA. Low-voltage fast seizures in humans begin with increased interneuron firing. Ann Neurol. 2018 10; 84(4):588-600. PMID: 30179277.
      View in: PubMed
    14. Engel J, Bragin A, Staba R. Nonictal EEG biomarkers for diagnosis and treatment. Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):120-126. PMID: 30564770.
      View in: PubMed
    15. Vespa PM, Shrestha V, Abend N, Agoston D, Au A, Bell MJ, Bleck TP, Blanco MB, Claassen J, Diaz-Arrastia R, Duncan D, Ellingson B, Foreman B, Gilmore EJ, Hirsch L, Hunn M, Kamnaksh A, McArthur D, Morokoff A, O'Brien T, O'Phelan K, Robertson CL, Rosenthal E, Staba R, Toga A, Willyerd FA, Zimmermann L, Yam E, Martinez S, Real C, Engel J. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Neurobiol Dis. 2019 03; 123:110-114. PMID: 30048805.
      View in: PubMed
    16. Weiss SA, Berry B, Chervoneva I, Waldman Z, Guba J, Bower M, Kucewicz M, Brinkmann B, Kremen V, Khadjevand F, Varatharajah Y, Guragain H, Sharan A, Wu C, Staba R, Engel J, Sperling M, Worrell G. Visually validated semi-automatic high-frequency oscillation detection aides the delineation of epileptogenic regions during intra-operative electrocorticography. Clin Neurophysiol. 2018 10; 129(10):2089-2098. PMID: 30077870.
      View in: PubMed
    17. Perucca P, Smith G, Santana-Gomez C, Bragin A, Staba R. Electrophysiological biomarkers of epileptogenicity after traumatic brain injury. Neurobiol Dis. 2019 03; 123:69-74. PMID: 29883622.
      View in: PubMed
    18. Vakharia VN, Duncan JS, Witt JA, Elger CE, Staba R, Engel J. Getting the best outcomes from epilepsy surgery. Ann Neurol. 2018 04; 83(4):676-690. PMID: 29534299.
      View in: PubMed
    19. Shimamoto S, Waldman ZJ, Orosz I, Song I, Bragin A, Fried I, Engel J, Staba R, Sharan A, Wu C, Sperling MR, Weiss SA. Utilization of independent component analysis for accurate pathological ripple detection in intracranial EEG recordings recorded extra- and intra-operatively. Clin Neurophysiol. 2018 01; 129(1):296-307. PMID: 29113719.
      View in: PubMed
    20. Waldman ZJ, Shimamoto S, Song I, Orosz I, Bragin A, Fried I, Engel J, Staba R, Sperling MR, Weiss SA. A method for the topographical identification and quantification of high frequency oscillations in intracranial electroencephalography recordings. Clin Neurophysiol. 2018 01; 129(1):308-318. PMID: 29122445.
      View in: PubMed
    21. Gloss D, Nevitt SJ, Staba R. The role of high-frequency oscillations in epilepsy surgery planning. Cochrane Database Syst Rev. 2017 10 05; 10:CD010235. PMID: 28981957.
      View in: PubMed
    22. Song I, Orosz I, Chervoneva I, Waldman ZJ, Fried I, Wu C, Sharan A, Salamon N, Gorniak R, Dewar S, Bragin A, Engel J, Sperling MR, Staba R, Weiss SA. Bimodal coupling of ripples and slower oscillations during sleep in patients with focal epilepsy. Epilepsia. 2017 11; 58(11):1972-1984. PMID: 28948998.
      View in: PubMed
    23. Jiruska P, Alvarado-Rojas C, Schevon CA, Staba R, Stacey W, Wendling F, Avoli M. Update on the mechanisms and roles of high-frequency oscillations in seizures and epileptic disorders. Epilepsia. 2017 08; 58(8):1330-1339. PMID: 28681378.
      View in: PubMed
    24. Weiss SA, Orosz I, Salamon N, Moy S, Wei L, Van't Klooster MA, Knight RT, Harper RM, Bragin A, Fried I, Engel J, Staba RJ. Ripples on spikes show increased phase-amplitude coupling in mesial temporal lobe epilepsy seizure-onset zones. Epilepsia. 2016 11; 57(11):1916-1930. PMID: 27723936.
      View in: PubMed
    25. Reid AY, Bragin A, Giza CC, Staba RJ, Engel J. The progression of electrophysiologic abnormalities during epileptogenesis after experimental traumatic brain injury. Epilepsia. 2016 Oct; 57(10):1558-1567. PMID: 27495360.
      View in: PubMed
    26. Galanopoulou AS, Wong M, Binder D, Hartman AL, Powell EM, Roopra A, Staba R, Vezzani A, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression. Epilepsy Curr. 2016 May-Jun; 16(3):187-91. PMID: 27330451.
      View in: PubMed
    27. Bragin A, Li L, Almajano J, Alvarado-Rojas C, Reid AY, Staba RJ, Engel J. Pathologic electrographic changes after experimental traumatic brain injury. Epilepsia. 2016 05; 57(5):735-45. PMID: 27012461.
      View in: PubMed
    28. Lopour BA, Staba RJ, Stern JM, Fried I, Ringach DL. Characterization of long-range functional connectivity in epileptic networks by neuronal spike-triggered local field potentials. J Neural Eng. 2016 Apr; 13(2):026031. PMID: 26975603.
      View in: PubMed
    29. Weiss SA, Alvarado-Rojas C, Bragin A, Behnke E, Fields T, Fried I, Engel J, Staba R. Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy. Epilepsia. 2016 Jan; 57(1):111-21. PMID: 26611159.
      View in: PubMed
    30. Memarian N, Kim S, Dewar S, Engel J, Staba RJ. Multimodal data and machine learning for surgery outcome prediction in complicated cases of mesial temporal lobe epilepsy. Comput Biol Med. 2015 Sep; 64:67-78. PMID: 26149291.
      View in: PubMed
    31. Menendez de la Prida L, Staba RJ, Dian JA. Conundrums of high-frequency oscillations (80-800 Hz) in the epileptic brain. J Clin Neurophysiol. 2015 Jun; 32(3):207-19. PMID: 26035673.
      View in: PubMed
    32. Memarian N, Madsen SK, Macey PM, Fried I, Engel J, Thompson PM, Staba RJ. Ictal depth EEG and MRI structural evidence for two different epileptogenic networks in mesial temporal lobe epilepsy. PLoS One. 2015; 10(4):e0123588. PMID: 25849340.
      View in: PubMed
    33. Staba RJ, Stead M, Worrell GA. Electrophysiological biomarkers of epilepsy. Neurotherapeutics. 2014 Apr; 11(2):334-46. PMID: 24519238.
      View in: PubMed
    34. Gloss D, Nolan SJ, Staba R. The role of high-frequency oscillations in epilepsy surgery planning. Cochrane Database Syst Rev. 2014 Jan 15; (1):CD010235. PMID: 24431136.
      View in: PubMed
    35. Reid AY, Staba RJ. Limbic networks: clinical perspective. Int Rev Neurobiol. 2014; 114:89-120. PMID: 25078500.
      View in: PubMed
    36. Staba RJ, Worrell GA. What is the importance of abnormal "background" activity in seizure generation? Adv Exp Med Biol. 2014; 813:43-54. PMID: 25012365.
      View in: PubMed
    37. Alvarado-Rojas C, Lehongre K, Bagdasaryan J, Bragin A, Staba R, Engel J, Navarro V, Le Van Quyen M. Single-unit activities during epileptic discharges in the human hippocampal formation. Front Comput Neurosci. 2013; 7:140. PMID: 24151464.
      View in: PubMed
    38. San-Juan D, Mayorga AP, Calcáneo Jde D, González-Aragón MF, Alonso-Vanegas M, Rico CD, Staba RJ, Anschel DJ, Cole AJ. Periodic epileptiform discharges in mesial temporal lobe epilepsy with hippocampal sclerosis. Seizure. 2013 Nov; 22(9):735-42. PMID: 23787169.
      View in: PubMed
    39. Memarian N, Thompson PM, Engel J, Staba RJ. Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy. Imaging Med. 2013 Jun 01; 5(3). PMID: 24319498.
      View in: PubMed
    40. Engel J, Thompson PM, Stern JM, Staba RJ, Bragin A, Mody I. Connectomics and epilepsy. Curr Opin Neurol. 2013 Apr; 26(2):186-94. PMID: 23406911.
      View in: PubMed
    41. Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson KÆ, Lapierre JL, Siegel JM. Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nat Commun. 2013; 4:1547. PMID: 23462990.
      View in: PubMed
    42. Jacobs J, Staba R, Asano E, Otsubo H, Wu JY, Zijlmans M, Mohamed I, Kahane P, Dubeau F, Navarro V, Gotman J. High-frequency oscillations (HFOs) in clinical epilepsy. Prog Neurobiol. 2012 Sep; 98(3):302-15. PMID: 22480752.
      View in: PubMed
    43. Andrillon T, Nir Y, Staba RJ, Ferrarelli F, Cirelli C, Tononi G, Fried I. Sleep spindles in humans: insights from intracranial EEG and unit recordings. J Neurosci. 2011 Dec 07; 31(49):17821-34. PMID: 22159098.
      View in: PubMed
    44. Staba RJ, Ekstrom AD, Suthana NA, Burggren A, Fried I, Engel J, Bookheimer SY. Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone. Epilepsia. 2012 Jan; 53(1):25-34. PMID: 22126325.
      View in: PubMed
    45. Staba RJ, Bragin A. High-frequency oscillations and other electrophysiological biomarkers of epilepsy: underlying mechanisms. Biomark Med. 2011 Oct; 5(5):545-56. PMID: 22003903.
      View in: PubMed
    46. San-juan D, Tapia CA, Claudia AT, González-Aragón MF, Maricarmen GA, Martínez Mayorga A, Adriana MM, Staba RJ, Richard JS, Alonso-Vanegas M, Mario AV. The prognostic role of electrocorticography in tailored temporal lobe surgery. Seizure. 2011 Sep; 20(7):564-9. PMID: 21616682.
      View in: PubMed
    47. Nir Y, Staba RJ, Andrillon T, Vyazovskiy VV, Cirelli C, Fried I, Tononi G. Regional slow waves and spindles in human sleep. Neuron. 2011 Apr 14; 70(1):153-69. PMID: 21482364.
      View in: PubMed
    48. Le Van Quyen M, Staba R, Bragin A, Dickson C, Valderrama M, Fried I, Engel J. Large-scale microelectrode recordings of high-frequency gamma oscillations in human cortex during sleep. J Neurosci. 2010 Jun 09; 30(23):7770-82. PMID: 20534826.
      View in: PubMed
    49. Bragin A, Engel J, Staba RJ. High-frequency oscillations in epileptic brain. Curr Opin Neurol. 2010 Apr; 23(2):151-6. PMID: 20160649.
      View in: PubMed
    50. Engel J, Akhtari M, Bragin A, Fried I, Ogren JA, Staba RJ, Salamon N, Thompson PM. New approaches to structural and functional imaging in focal epilepsy. Epilepsia. 2010 Feb; 51 Suppl 1:83-6. PMID: 20331726.
      View in: PubMed
    51. Ogren JA, Wilson CL, Bragin A, Lin JJ, Salamon N, Dutton RA, Luders E, Fields TA, Fried I, Toga AW, Thompson PM, Engel J, Staba RJ. Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus. Ann Neurol. 2009 Dec; 66(6):783-91. PMID: 20035513.
      View in: PubMed
    52. Engel J, Bragin A, Staba R, Mody I. High-frequency oscillations: what is normal and what is not? Epilepsia. 2009 Apr; 50(4):598-604. PMID: 19055491.
      View in: PubMed
    53. Ogren JA, Bragin A, Wilson CL, Hoftman GD, Lin JJ, Dutton RA, Fields TA, Toga AW, Thompson PM, Engel J, Staba RJ. Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patterns. Epilepsia. 2009 Jun; 50(6):1361-70. PMID: 19054395.
      View in: PubMed
    54. Le Van Quyen M, Bragin A, Staba R, Crépon B, Wilson CL, Engel J. Cell type-specific firing during ripple oscillations in the hippocampal formation of humans. J Neurosci. 2008 Jun 11; 28(24):6104-10. PMID: 18550752.
      View in: PubMed
    55. Staba RJ, Frighetto L, Behnke EJ, Mathern GW, Fields T, Bragin A, Ogren J, Fried I, Wilson CL, Engel J. Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients. Epilepsia. 2007 Nov; 48(11):2130-8. PMID: 17662059.
      View in: PubMed
    56. Staba RJ, Ard TD, Benison AM, Barth DS. Intracortical pathways mediate nonlinear fast oscillation (>200 Hz) interactions within rat barrel cortex. J Neurophysiol. 2005 May; 93(5):2934-9. PMID: 15590723.
      View in: PubMed
    57. Staba RJ, Bergmann PC, Barth DS. Dissociation of slow waves and fast oscillations above 200 Hz during GABA application in rat somatosensory cortex. J Physiol. 2004 Nov 15; 561(Pt 1):205-14. PMID: 15550468.
      View in: PubMed
    58. Staba RJ, Wilson CL, Bragin A, Jhung D, Fried I, Engel J. High-frequency oscillations recorded in human medial temporal lobe during sleep. Ann Neurol. 2004 Jul; 56(1):108-15. PMID: 15236407.
      View in: PubMed
    59. Brett-Green B, Paulsen M, Staba RJ, Fifková E, Barth DS. Two distinct regions of secondary somatosensory cortex in the rat: topographical organization and multisensory responses. J Neurophysiol. 2004 Mar; 91(3):1327-36. PMID: 14586034.
      View in: PubMed
    60. Staba RJ, Brett-Green B, Paulsen M, Barth DS. Effects of ventrobasal lesion and cortical cooling on fast oscillations (>200 Hz) in rat somatosensory cortex. J Neurophysiol. 2003 May; 89(5):2380-8. PMID: 12611970.
      View in: PubMed
    61. Bragin A, Wilson CL, Staba RJ, Reddick M, Fried I, Engel J. Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex. Ann Neurol. 2002 Oct; 52(4):407-15. PMID: 12325068.
      View in: PubMed
    62. Staba RJ, Wilson CL, Bragin A, Fried I, Engel J. Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. J Neurophysiol. 2002 Oct; 88(4):1743-52. PMID: 12364503.
      View in: PubMed
    63. Staba RJ, Wilson CL, Bragin A, Fried I, Engel J. Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum. J Neurosci. 2002 Jul 01; 22(13):5694-704. PMID: 12097521.
      View in: PubMed
    64. Staba RJ, Wilson CL, Fried I, Engel J. Single neuron burst firing in the human hippocampus during sleep. Hippocampus. 2002; 12(6):724-34. PMID: 12542225.
      View in: PubMed
    65. Shouse MN, Staba RJ, Ko PY, Saquib SF, Farber PR. Monoamines and seizures: microdialysis findings in locus ceruleus and amygdala before and during amygdala kindling. Brain Res. 2001 Feb 16; 892(1):176-92. PMID: 11172762.
      View in: PubMed
    66. Shouse MN, Staba RJ, Saquib SF, Farber PR. Long-lasting effects of feline amygdala kindling on monoamines, seizures and sleep. Brain Res. 2001 Feb 16; 892(1):147-65. PMID: 11172760.
      View in: PubMed
    67. Shouse MN, Farber PR, Staba RJ. Physiological basis: how NREM sleep components can promote and REM sleep components can suppress seizure discharge propagation. Clin Neurophysiol. 2000 Sep; 111 Suppl 2:S9-S18. PMID: 10996550.
      View in: PubMed
    68. Rector DM, Richard CA, Staba RJ, Harper RM. Sleep states alter ventral medullary surface responses to blood pressure challenges. Am J Physiol Regul Integr Comp Physiol. 2000 Apr; 278(4):R1090-8. PMID: 10749799.
      View in: PubMed
    69. Shouse MN, Staba RJ, Saquib SF, Farber PR. Monoamines and sleep: microdialysis findings in pons and amygdala. Brain Res. 2000 Mar 31; 860(1-2):181-9. PMID: 10727641.
      View in: PubMed