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Shaun Alexander Hussain

Title(s)Professor Of Clinical, Pediatrics
SchoolMedicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Self-supervised data-driven approach defines pathological high-frequency oscillations in epilepsy. Epilepsia. 2025 Jul 12. Zhang Y, Daida A, Liu L, Kuroda N, Ding Y, Oana S, Kanai S, Monsoor T, Duan C, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Sankar R, Staba RJ, Engel J, Asano E, Roychowdhury V, Nariai H. PMID: 40650866; PMCID: PMC12266643.
      View in: PubMed   Mentions:    Fields:    
    2. Evidence of thalamocortical network activation during epileptic spasms: A thalamic stereotactic EEG study. Epilepsia. 2025 Jul; 66(7):2407-2420. Daida A, Panchavati S, Oana S, Kanai S, Zhang Y, Ding Y, Rajsekar RR, Salamon N, Sankar R, Fallah A, Hussain SA, Roychowdhury V, Speier W, Nariai H. PMID: 40053323.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Symptomatic vigabatrin-associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms. Epilepsia Open. 2025 Feb; 10(1):314-320. Sathe R, Shrestha G, Terango A, Tabibzadeh D, Rajaraman RR, Nariai H, Hussain SA. PMID: 39570186; PMCID: PMC11803263.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Self-Supervised Data-Driven Approach Defines Pathological High-Frequency Oscillations in Human. medRxiv. 2024 Nov 05. Zhang Y, Daida A, Liu L, Kuroda N, Ding Y, Oana S, Kanai S, Monsoor T, Duan C, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Sankar R, Staba RJ, Engel J, Asano E, Roychowdhury V, Nariai H. PMID: 39040207; PMCID: PMC11261948.
      View in: PubMed   Mentions: 1  
    5. Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy. N Engl J Med. 2024 10 10; 391(14):1302-1312. Eichler F, Duncan CN, Musolino PL, Lund TC, Gupta AO, De Oliveira S, Thrasher AJ, Aubourg P, Kühl JS, Loes DJ, Amartino H, Smith N, Folloni Fernandes J, Sevin C, Sankar R, Hussain SA, Gissen P, Dalle JH, Platzbecker U, Downey GF, McNeil E, Demopoulos L, Dietz AC, Thakar HL, Orchard PJ, Williams DA. PMID: 39383459.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsCTClinical Trials
    6. Overnight Electroencephalogram to Forecast Epilepsy Development in Children with Autism Spectrum Disorders. J Pediatr. 2024 Nov; 274:114217. Daida A, Oana S, Nadkarni D, Espiritu BL, Edmonds BD, Stanecki C, Samuel AS, Rao LM, Rajaraman RR, Hussain SA, Matsumoto JH, Sankar R, Hannauer PS, Nariai H. PMID: 39074735.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Bilateral centromedian nucleus of thalamus responsive neurostimulation for pediatric-onset drug-resistant epilepsy. Epilepsia. 2024 Aug; 65(8):e131-e140. Ahn S, Edmonds B, Rajaraman RR, Rao LM, Hussain SA, Matsumoto JH, Sankar R, Salamon N, Fallah A, Nariai H. PMID: 38845459; PMCID: PMC11315622.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. PyHFO: lightweight deep learning-powered end-to-end high-frequency oscillations analysis application. J Neural Eng. 2024 05 28; 21(3). Zhang Y, Liu L, Ding Y, Chen X, Monsoor T, Daida A, Oana S, Hussain S, Sankar R, Fallah A, Santana-Gomez C, Engel J, Staba RJ, Speier W, Zhang J, Nariai H, Roychowdhury V. PMID: 38722308; PMCID: PMC11135143.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    9. Computational EEG attributes predict response to therapy for epileptic spasms. Clin Neurophysiol. 2024 Jul; 163:39-46. Rajaraman RR, Smith RJ, Oana S, Daida A, Shrey DW, Nariai H, Lopour BA, Hussain SA. PMID: 38703698.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Epileptic spasms relapse is associated with response latency but not conventional attributes of post-treatment EEG. Epilepsia Open. 2024 Jun; 9(3):1034-1041. Deckard E, Sathe R, Tabibzadeh D, Terango A, Groves A, Rajaraman RR, Nariai H, Hussain SA. PMID: 38588009; PMCID: PMC11145600.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Optimizing detection and deep learning-based classification of pathological high-frequency oscillations in epilepsy. Clin Neurophysiol. 2023 10; 154:129-140. Monsoor T, Zhang Y, Daida A, Oana S, Lu Q, Hussain SA, Fallah A, Sankar R, Staba RJ, Speier W, Roychowdhury V, Nariai H. PMID: 37603979; PMCID: PMC10861270.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Characterizing physiological high-frequency oscillations using deep learning. J Neural Eng. 2022 12 07; 19(6). Zhang Y, Chung H, Ngo JP, Monsoor T, Hussain SA, Matsumoto JH, Walshaw PD, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V, Nariai H. PMID: 36541546; PMCID: PMC10364130.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms. Neurology. 2022 11 29; 99(22):e2494-e2503. Yuskaitis CJ, Mytinger JR, Baumer FM, Zhang B, Liu S, Samanta D, Hussain SA, Yozawitz EG, Keator CG, Joshi C, Singh RK, Bhatia S, Bhalla S, Shellhaas R, Harini C, Pediatric Epilepsy Research Consortium. PMID: 36038267; PMCID: PMC9728034.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study. Neurosurgery. 2021 11 18; 89(6):997-1004. Nagahama Y, Zervos TM, Murata KK, Holman L, Karsonovich T, Parker JJ, Chen JS, Phillips HW, Fajardo M, Nariai H, Hussain SA, Porter BE, Grant GA, Ragheb J, Wang S, O'Neill BR, Alexander AL, Bollo RJ, Fallah A. PMID: 34528103; PMCID: PMC8637802.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    15. Refining epileptogenic high-frequency oscillations using deep learning: a reverse engineering approach. Brain Commun. 2022; 4(1):fcab267. Zhang Y, Lu Q, Monsoor T, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V, Nariai H. PMID: 35169696; PMCID: PMC8833577.
      View in: PubMed   Mentions: 14  
    16. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Sep 20; 97(12):e1217-e1228. Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell EC, Valencia I, Singhal NS, Nordli DR, Mytinger JR, Mitchell WG, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. PMID: 34266919; PMCID: PMC8480478.
      View in: PubMed   Mentions: 11     Fields:    
    17. Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome. Mol Autism. 2021 08 03; 12(1):54. Saravanapandian V, Nadkarni D, Hsu SH, Hussain SA, Maski K, Golshani P, Colwell CS, Balasubramanian S, Dixon A, Geschwind DH, Jeste SS. PMID: 34344470; PMCID: PMC8336244.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    18. Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology. Epilepsy Behav. 2021 02; 115:107624. Hussain SA, Heesch J, Weng J, Rajaraman RR, Numis AL, Sankar R. PMID: 33341392.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Scalp EEG interictal high frequency oscillations as an objective biomarker of infantile spasms. Clin Neurophysiol. 2020 11; 131(11):2527-2536. Nariai H, Hussain SA, Bernardo D, Motoi H, Sonoda M, Kuroda N, Asano E, Nguyen JC, Elashoff D, Sankar R, Bragin A, Staba RJ, Wu JY. PMID: 32927206; PMCID: PMC7606823.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    20. Felbamate in the treatment of refractory epileptic spasms. Epilepsy Res. 2020 03; 161:106284. Hussain SA, Asilnejad B, Heesch J, Navarro M, Ji M, Shrey DW, Rajaraman RR, Sankar R. PMID: 32058261.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Limited efficacy of zonisamide in the treatment of refractory infantile spasms. Epilepsia Open. 2020 Mar; 5(1):121-126. Hussain SA, Navarro M, Heesch J, Ji M, Asilnejad B, Peters H, Rajaraman RR, Sankar R. PMID: 32140650; PMCID: PMC7049796.
      View in: PubMed   Mentions: 3     Fields:    
    22. The economic burden of caregiving in epilepsy: An estimate based on a survey of US caregivers. Epilepsia. 2020 02; 61(2):319-329. Hussain SA, Ortendahl JD, Bentley TGK, Harmon AL, Gupta S, Begley CE, Khilfeh I, Knoth RL. PMID: 31953846.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    23. Synthetic pharmaceutical grade cannabidiol for treatment of refractory infantile spasms: A multicenter phase-2 study. Epilepsy Behav. 2020 01; 102:106826. Hussain SA, Dlugos DJ, Cilio MR, Parikh N, Oh A, Sankar R. PMID: 31816477.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    24. Prospective observational study: Fast ripple localization delineates the epileptogenic zone. Clin Neurophysiol. 2019 11; 130(11):2144-2152. Nariai H, Hussain SA, Bernardo D, Fallah A, Murata KK, Nguyen JC, Rajaraman RR, Rao LM, Matsumoto JH, Lerner JT, Salamon N, Elashoff D, Sankar R, Wu JY. PMID: 31569042.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    25. The equivalence of the ketogenic diet and adrenocorticotropic hormone for treatment of infantile spasms: More suggestion than conclusion. Epilepsia. 2019 10; 60(10):2145. Hussain SA. PMID: 31460668.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol. Pediatr Neurol. 2019 10; 99:16-22. Eliyan Y, Heesch J, Alayari A, Rajaraman RR, Sankar R, Hussain SA. PMID: 31331669.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    27. Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism. Seizure. 2019 Oct; 71:29-34. Weng JK, Ahn R, Hussain SA. PMID: 31202190.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Interrater reliability in visual identification of interictal high-frequency oscillations on electrocorticography and scalp EEG. Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):127-132. Nariai H, Wu JY, Bernardo D, Fallah A, Sankar R, Hussain SA. PMID: 30564771; PMCID: PMC6293061.
      View in: PubMed   Mentions: 15     Fields:    
    29. Treatment of infantile spasms. Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):143-154. Hussain SA. PMID: 30564773; PMCID: PMC6293071.
      View in: PubMed   Mentions: 20     Fields:    
    30. A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. Epilepsy Behav. 2018 11; 88:212-217. Rao LM, Hussain SA, Zaki T, Cho A, Chanlaw T, Garg M, Sankar R. PMID: 30296665.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    31. High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. Epilepsy Res. 2018 12; 148:1-7. Hussain SA, Schmid E, Peters JM, Goyal M, Bebin EM, Northrup H, Sahin M, Krueger DA, Wu JY, Tuberous Sclerosis Complex Autism Center of Excellence Network. PMID: 30296632; PMCID: PMC6347124.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    32. Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus. Epilepsy Behav Case Rep. 2018; 10:141-144. Rajaraman RR, Sankar R, Hussain SA. PMID: 30596011; PMCID: PMC6306515.
      View in: PubMed   Mentions: 2  
    33. Amantadine: A new treatment for refractory electrical status epilepticus in sleep. Epilepsy Behav. 2018 07; 84:74-78. Wilson RB, Eliyan Y, Sankar R, Hussain SA. PMID: 29754107.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    34. Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex. Clin Neurophysiol. 2018 07; 129(7):1458-1466. Bernardo D, Nariai H, Hussain SA, Sankar R, Salamon N, Krueger DA, Sahin M, Northrup H, Bebin EM, Wu JY, UCLA Pediatric Epilepsy Group, TACERN Study Group. PMID: 29673547.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    35. Reply. J Pediatr. 2018 06; 197:319. Hussain SA. PMID: 29550223.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Recognition of Infantile Spasms Is Often Delayed: The ASSIST Study. J Pediatr. 2017 11; 190:215-221.e1. Hussain SA, Lay J, Cheng E, Weng J, Sankar R, Baca CB. PMID: 29144248.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    37. Intraoperative fast ripples independently predict postsurgical epilepsy outcome: Comparison with other electrocorticographic phenomena. Epilepsy Res. 2017 09; 135:79-86. Hussain SA, Mathern GW, Hung P, Weng J, Sankar R, Wu JY. PMID: 28644979; PMCID: PMC5568451.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    38. Risk of vigabatrin-associated brain abnormalities on MRI in the treatment of infantile spasms is dose-dependent. Epilepsia. 2017 04; 58(4):674-682. Hussain SA, Tsao J, Li M, Schwarz MD, Zhou R, Wu JY, Salamon N, Sankar R. PMID: 28230253.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    39. Conductive Plastic Electrodes Reduce EEG Artifact During Pediatric ECMO Therapy. J Clin Neurophysiol. 2016 Oct; 33(5):426-430. Matsumoto JH, McArthur DL, Szeliga CW, Lerner JT, Rao LM, Hussain SA, Wu JY, Nuwer MR, Sankar R. PMID: 26886103.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Prospective and "live" fast ripple detection and localization in the operating room: Impact on epilepsy surgery outcomes in children. Epilepsy Res. 2016 11; 127:344-351. Hussain SA, Mathern GW, Sankar R, Wu JY. PMID: 27721161.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    41. Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit. Epilepsia. 2016 08; 57(8):1280-7. Rajaraman RR, Lay J, Alayari A, Anderson K, Sankar R, Hussain SA. PMID: 27312124.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    42. A lack of clinically apparent vision loss among patients treated with vigabatrin with infantile spasms: The UCLA experience. Epilepsy Behav. 2016 Apr; 57(Pt A):29-33. Schwarz MD, Li M, Tsao J, Zhou R, Wu YW, Sankar R, Wu JY, Hussain SA. PMID: 26921595.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    43. A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I. Ann Clin Transl Neurol. 2016 04; 3(4):266-79. Bearden CE, Hellemann GS, Rosser T, Montojo C, Jonas R, Enrique N, Pacheco L, Hussain SA, Wu JY, Ho JS, McGough JJ, Sugar CA, Silva AJ. PMID: 27081657; PMCID: PMC4818747.
      View in: PubMed   Mentions: 33     Fields:    
    44. Limited efficacy of the ketogenic diet in the treatment of highly refractory epileptic spasms. Seizure. 2016 Feb; 35:59-64. Hussain SA, Shin JH, Shih EJ, Murata KK, Sewak S, Kezele ME, Sankar R, Matsumoto JH. PMID: 26803052.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    45. Improving the inter-rater agreement of hypsarrhythmia using a simplified EEG grading scale for children with infantile spasms. Epilepsy Res. 2015 Oct; 116:93-8. Mytinger JR, Hussain SA, Islam MP, Millichap JJ, Patel AD, Ryan NR, Twanow JD, Heyer GL. PMID: 26280806.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    46. Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome. Epilepsy Behav. 2015 Jun; 47:138-41. Hussain SA, Zhou R, Jacobson C, Weng J, Cheng E, Lay J, Hung P, Lerner JT, Sankar R. PMID: 25935511.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimals
    47. Hypsarrhythmia assessment exhibits poor interrater reliability: a threat to clinical trial validity. Epilepsia. 2015 Jan; 56(1):77-81. Hussain SA, Kwong G, Millichap JJ, Mytinger JR, Ryan N, Matsumoto JH, Wu JY, Lerner JT, Sankar R. PMID: 25385396.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    48. Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. Epilepsia. 2014 Jan; 55(1):103-7. Hussain SA, Shinnar S, Kwong G, Lerner JT, Matsumoto JH, Wu JY, Shields WD, Sankar R. PMID: 24446954; PMCID: PMC3904676.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    49. Pharmacologic treatment of intractable epilepsy in children: a syndrome-based approach. Semin Pediatr Neurol. 2011 Sep; 18(3):171-8. Hussain S, Sankar R. PMID: 22062941.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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