Lin Chang

Title(s)Professor, Medicine
SchoolMedicine
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    Bidirectional Brain-Gut Signaling in the Persistence of IBS-like Symptoms in Inflammatory Bowel Disease
    NIH R01DK147396Sep 15, 2026 - Jun 30, 2031
    Role: Principal Investigator
    Sex related differences in Brain Gut Microbiome Interactions in Irritable Bowel Syndrome
    NIH U54DK123755May 1, 2020 - Jun 30, 2031
    Role: Co-Principal Investigator
    DNA Methylation Based Biomarkers and Epigenetic Regulation in IBS
    NIH R21DK104078Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Neuroendocrine Alterations in Fibromyalgia and IBS
    NIH R01AR046122Sep 13, 1999 - Jan 31, 2012
    Role: Principal Investigator
    Collapse Clinical Trials

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Irritable bowel syndrome. Nat Rev Dis Primers. 2026 Oct 01; 12(1). Chang L, Corsetti M, Chey WD, Ford AC, Schmulson MJ, Shin A, Barbara G, Ballou S, Mayer EA, Siah KT, Simrén M, Staudacher H, Lembo AJ. PMID: 42823420.
      View in: PubMed   Mentions:
    2. Managing Complex Irritable Bowel Syndrome: A Multidisciplinary, Mechanism-Based Approach. Gastroenterology. 2026 Aug 04. Chang L, Bedell A, Smith J, Smith S, Lembo A. PMID: 42551569.
      View in: PubMed   Mentions:
    3. Social determinants of health and sex differences: insights from NIH Specialized Centers of Research Excellence (SCORE). Biol Sex Differ. 2026 Jun 08; 17(1). A McKee S, Chang L, M Aris I. PMID: 42260681; PMCID: PMC13245042.
      View in: PubMed   Mentions:    Fields:    
    4. Recommendations for the Evaluation and Management of Inflammatory Bowel Disease With Irritable Bowel Syndrome-Like Symptoms: A Joint Rome Foundation and International Organization for the Study of IBD (IOIBD) Consensus. Gastroenterology. 2026 Sep; 171(3):504-520. Ma C, Ford AC, Hashash JG, Barbara G, Bernstein CN, Brenner DM, Griffiths AM, Keefer L, Long MD, Nurko S, Singh P, Sands BE, Chang L. PMID: 42066865.
      View in: PubMed   Mentions:    Fields:    
    5. Disparities in Health Care Seeking and Physician Diagnosis of Irritable Bowel Syndrome: Results From a United States Survey. Clin Gastroenterol Hepatol. 2026 Mar 25. Almario CV, Liu J, Higgins C, Yerneni N, Boules M, Chey WD, Chang L. PMID: 41895674.
      View in: PubMed   Mentions: 1     Fields:    
    6. Increased Autoimmunity Burden Is a Risk Factor for Developing Irritable Bowel Syndrome-Like Symptoms in Quiescent Inflammatory Bowel Disease. Dig Dis Sci. 2026 Jun; 71(6):2340-2346. Chang A, Shahrvini B, Oh J, Prajapati DP, Baniqued M, Harmon R, Greb AC, Bonthala N, Sauk JS, Shin A, Chang L, Limketkai BN. PMID: 41483434; PMCID: PMC13357454.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome. Neurogastroenterol Motil. 2025 Dec; 37(12):e70199. Yuan PQ, Nash M, Li T, Mahurkar-Joshi S, Sohn J, Khandadash A, Taché Y, Chang L. PMID: 41177834; PMCID: PMC12623276.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Biomarkers in Irritable Bowel Syndrome: Rationale and Practical Use. Gastroenterol Clin North Am. 2026 03; 55(1):91-105. Guan M, Chang L. PMID: 41581955.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Sex-based associations between neighborhood disadvantage and brain-gut alterations in individuals with irritable bowel syndrome. Biol Sex Differ. 2025 08 11; 16(1):61. Kilpatrick LA, Chang L, Labus JS, Shin AS, Choy M, Dong TS, Naliboff B, Mayer EA, Church A. PMID: 40790507; PMCID: PMC12337488.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Extraintestinal Symptoms in Irritable Bowel Syndrome Are Associated With Stress Reactivity and the Gut Microbiome in a Sex-dependent Manner. Clin Gastroenterol Hepatol. 2026 Mar; 24(3):854-857. Jacobs JP, Labus JS, Dong TS, Shin AS, UCLA SCORE Group in IBS and Sex Differences, Mayer EA, Chang L. PMID: 40744347; PMCID: PMC12995157.
      View in: PubMed   Mentions:    Fields:    
    11. Research Communication: An Observational Cohort Study on Risk of Ovarian Cancer in Women with Irritable Bowel Syndrome. Aliment Pharmacol Ther. 2025 Nov; 62(9):944-947. Shin A, Xu H, Sarnoff R, Church A, Chang L. PMID: 41081454; PMCID: PMC13147301.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Differential brainstem connectivity according to sex and menopausal status in healthy male and female individuals. Biol Sex Differ. 2025 04 18; 16(1):25. Kilpatrick LA, Church A, Meriwether D, Mahurkar-Joshi S, Li VW, Sohn J, Reist J, Labus JS, Dong T, Jacobs JP, Naliboff BD, Chang L, Mayer EA. PMID: 40251694; PMCID: PMC12007138.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Gut Feelings: The Critical Role of Interoception in Obesity and Disorders of Gut-Brain Interaction. Gastroenterology. 2025 Aug; 169(2):188-194. Chang L, Thaiss CA, Knight Z, Khalsa S. PMID: 40250772.
      View in: PubMed   Mentions: 1     Fields:    
    14. Sex-dependent alterations of colonic epithelial permeability: relevance to irritable bowel syndrome. Front Physiol. 2025; 16:1509935. Larauche M, Mahurkar-Joshi S, Biraud M, Ju T, Mayer EA, Chang L. PMID: 40061455; PMCID: PMC11885305.
      View in: PubMed   Mentions: 4  
    15. Rome Foundation Working Team Report on overlap in disorders of gut-brain interaction. Nat Rev Gastroenterol Hepatol. 2025 Apr; 22(4):228-251. Barbara G, Aziz I, Ballou S, Chang L, Ford AC, Fukudo S, Nurko S, Olano C, Saps M, Sayuk G, Siah KTH, Van Oudenhove L, Simrén M. PMID: 39870943.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. AGA Institute Quality Indicator Development for Irritable Bowel Syndrome. Gastroenterology. 2025 Mar; 168(3):612-622.e4. Hung KW, Leiman DA, Kaza A, Watson R, Chang L, Maratt JK, American Gastroenterological Association Quality Committee. Electronic address: dgodzina@gastro.org. PMID: 39818650.
      View in: PubMed   Mentions: 1     Fields:    
    17. Sex Differences, Menses-Related Symptoms and Menopause in Disorders of Gut-Brain Interaction. Neurogastroenterol Motil. 2025 Feb; 37(2):e14977. Sarnoff RP, Hreinsson JP, Kim J, Sperber AD, Palsson OS, Bangdiwala SI, Chang L. PMID: 39748465; PMCID: PMC11748819.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Reply. Gastroenterology. 2025 Apr; 168(4):837-838. Dong TS, Chang L. PMID: 39710344.
      View in: PubMed   Mentions:    Fields:    
    19. Genome-Wide DNA Methylation Identifies Potential Disease-Specific Biomarkers and Pathophysiologic Mechanisms in Irritable Bowel Syndrome, Inflammatory Bowel Disease, and Celiac Disease. Neurogastroenterol Motil. 2025 Feb; 37(2):e14980. Mahurkar-Joshi S, Thompson M, Villarruel E, Lewis JD, Lin LD, Farid M, Nayeb-Hashemi H, Storage T, Weiss GA, Limketkai BN, Sauk JS, Mayer EA, Chang L. PMID: 39673136; PMCID: PMC11748828.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. The Impact and Interactions of Race and Gender on Healthcare Use and Spending in Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2025 Jul; 23(8):1428-1439.e7. Shin A, Sarnoff R, Church A, Xu H, Chang L. PMID: 39637928; PMCID: PMC13147302.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Highlights From the Joint AGA/ACG Guideline on Pharmacologic Management of Chronic Idiopathic Constipation. Gastroenterol Hepatol (N Y). 2024 Nov; 20(11):678-681. Chang L. PMID: 39886333; PMCID: PMC11775994.
      View in: PubMed   Mentions: 1  
    22. Opioid and Nonopioid Analgesic Prescribing Patterns of Hepatologists for Medicare Beneficiaries. Clin Transl Gastroenterol. 2024 10 01; 15(10):e1. Iyengar P, Prause N, LeBrett W, Lee A, Chang L, Patel A. PMID: 39082613; PMCID: PMC11500778.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Intestinal Permeability in Disorders of Gut-Brain Interaction: From Bench to Bedside. Gastroenterology. 2025 03; 168(3):480-495. Grover M, Vanuytsel T, Chang L. PMID: 39236897.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    24. Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility. Neurogastroenterol Motil. 2024 Oct; 36(10):e14869. Butt MF, Groen J, Jonker CAL, Burton-Murray H, Carrington EV, Chang L, Di Lorenzo C, Ellis J, Escher JC, Gorter RR, Jewell S, Karrento K, Koster EC, Nurko S, Rosen R, van Tilburg MAL, Zarate-Lopez N, Corsetti M, Benninga MA. PMID: 39038114; PMCID: PMC11486583.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Prevotella Is Associated With Sex-Based Differences in Irritable Bowel Syndrome. Gastroenterology. 2024 Nov; 167(6):1221-1224.e8. Dong TS, Peters K, Gupta A, Jacobs JP, UCLA SCORE Group in IBS and Sex Differences, Chang L. PMID: 39004155; PMCID: PMC11845270.
      View in: PubMed   Mentions: 4     Fields:    
    26. Role of Sex, Anxiety, and Resilience in the Association Between Adverse Childhood Experiences and Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2025 01; 23(1):154-162.e2. Lee AH, Mahurkar-Joshi S, Naliboff B, Gupta A, Labus J, Tillisch K, Mayer E, Chang L. PMID: 38878847; PMCID: PMC11648812.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation. Clin Exp Gastroenterol. 2024; 17:87-96. Singh P, Sayuk GS, Rosenbaum DP, Edelstein S, Kozuka K, Chang L. PMID: 38617992; PMCID: PMC11016248.
      View in: PubMed   Mentions: 6  
    28. Patient-Reported Outcomes in Disorders of Gut-Brain Interaction. Gastroenterology. 2024 04; 166(4):572-587.e1. Tack J, Carbone F, Chang L, Lacy BE. PMID: 38309628.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    29. Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis. Am J Gastroenterol. 2024 05 01; 119(5):937-945. Lembo AJ, Chey WD, Harris LA, Frazier R, Brenner DM, Chang L, Lacy BE, Edelstein S, Yang Y, Zhao S, Rosenbaum DP. PMID: 38294158; PMCID: PMC11062617.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons. Am J Physiol Gastrointest Liver Physiol. 2024 05 01; 326(5):G543-G554. King AJ, Chang L, Li Q, Liu L, Zhu Y, Pasricha PJ, Wang J, Siegel M, Caldwell JS, Edelstein S, Rosenbaum DP, Kozuka K. PMID: 38252683; PMCID: PMC11376972.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    31. Neural correlates of perceived and relative resilience in male and female patients with irritable bowel syndrome. Neurogastroenterol Motil. 2024 Feb; 36(2):e14710. Kilpatrick LA, Gupta A, Tillisch K, Labus JS, Naliboff BD, Mayer EA, Chang L. PMID: 38031358; PMCID: PMC11014739.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    32. The Association Between a Mediterranean Diet and Symptoms of Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2024 01; 22(1):164-172.e6. Chen EY, Mahurkar-Joshi S, Liu C, Jaffe N, Labus JS, Dong TS, Gupta A, Patel S, Mayer EA, Chang L. PMID: 37517631; PMCID: PMC10849937.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    33. American Gastroenterological Association-American College of Gastroenterology Clinical Practice Guideline: Pharmacological Management of Chronic Idiopathic Constipation. Gastroenterology. 2023 06; 164(7):1086-1106. Chang L, Chey WD, Imdad A, Almario CV, Bharucha AE, Diem S, Greer KB, Hanson B, Harris LA, Ko C, Murad MH, Patel A, Shah ED, Lembo AJ, Sultan S. PMID: 37211380; PMCID: PMC10542656.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    34. Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review. Gastroenterology. 2022 10; 163(4):995-1023.e3. Zia JK, Lenhart A, Yang PL, Heitkemper MM, Baker J, Keefer L, Saps M, Cuff C, Hungria G, Videlock EJ, Chang L. PMID: 35716771; PMCID: PMC9509486.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
    35. AGA Clinical Practice Update on the Role of Diet in Irritable Bowel Syndrome: Expert Review. Gastroenterology. 2022 05; 162(6):1737-1745.e5. Chey WD, Hashash JG, Manning L, Chang L. PMID: 35337654.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    36. High Opioid Prescribing Profiles Among Gastroenterologists: A Nationwide Analysis. Clin Gastroenterol Hepatol. 2022 12; 20(12):2918-2920.e1. LeBrett WG, Iyengar PS, Lee AH, Chen FW, Chang L. PMID: 34666155.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Gender and Other Factors Associated with Endoscopy Volume Among U.S. Gastroenterology Fellows. Clin Gastroenterol Hepatol. 2022 12; 20(12):2911-2914.e4. Lenhart A, Chen F, Condon A, Kardashian A, El-Nachef N, UCLA GI DIVISION BIOSTATISTICS, Chang L. PMID: 34628079.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Latest Insights on the Pathogenesis of Irritable Bowel Syndrome. Gastroenterol Clin North Am. 2021 09; 50(3):505-522. Videlock EJ, Chang L. PMID: 34304785.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    39. How to Approach a Patient with Difficult-to-Treat IBS. Gastroenterology. 2021 10; 161(4):1092-1098.e3. Chang L. PMID: 34331916.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    40. Effect of Exclusion Diets on Symptom Severity and the Gut Microbiota in Patients With Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2022 03; 20(3):e465-e483. Lenhart A, Dong T, Joshi S, Jaffe N, Choo C, Liu C, Jacobs JP, Lagishetty V, Shih W, Labus JS, Gupta A, Tillisch K, Mayer EA, Chang L. PMID: 34022450; PMCID: PMC9054035.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    41. The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p, and MicroRNA-338-3p Are Downregulated in Irritable Bowel Syndrome and Are Associated With Barrier Function and MAPK Signaling. Gastroenterology. 2021 06; 160(7):2409-2422.e19. Mahurkar-Joshi S, Rankin CR, Videlock EJ, Soroosh A, Verma A, Khandadash A, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. PMID: 33617890; PMCID: PMC8169529.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    42. The Role of Resilience in Irritable Bowel Syndrome, Other Chronic Gastrointestinal Conditions, and the General Population. Clin Gastroenterol Hepatol. 2021 12; 19(12):2541-2550.e1. Parker CH, Naliboff BD, Shih W, Presson AP, Kilpatrick L, Gupta A, Liu C, Keefer LA, Sauk JS, Hirten R, Sands BE, Chang L. PMID: 32835842; PMCID: PMC7897330.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    43. Opioid Prescription Patterns Among US Gastroenterologists From 2013 to 2017. Gastroenterology. 2020 02; 158(3):776-779.e2. Chen FW, LeBrett WG, Yang L, Chang L. PMID: 31647903.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    44. The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018. PLoS One. 2019; 14(6):e0218578. Lutfiyya MN, Chang LF, McGrath C, Dana C, Lipsky MS. PMID: 31242239; PMCID: PMC6594675.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    45. Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity. Cells. 2019 01 30; 8(2). Hagiwara SI, Hasdemir B, Heyman MB, Chang L, Bhargava A. PMID: 30704133; PMCID: PMC6406316.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    46. Negative Events During Adulthood Are Associated With Symptom Severity and Altered Stress Response in Patients With Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2019 10; 17(11):2245-2252. Parker CH, Naliboff BD, Shih W, Presson AP, Videlock EJ, Mayer EA, Chang L. PMID: 30616026; PMCID: PMC6609507.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    47. Sex-Related Differences in GI Disorders. Handb Exp Pharmacol. 2017; 239:177-192. Prusator DK, Chang L. PMID: 28233176.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    48. Effects of baseline abdominal pain and bloating on response to lubiprostone in patients with irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2016 11; 44(10):1114-1122. Chang L, Chey WD, Drossman D, Losch-Beridon T, Wang M, Lichtlen P, Mareya S. PMID: 27669680; PMCID: PMC5215520.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCTClinical Trials
    49. Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response. Psychoneuroendocrinology. 2016 11; 73:133-141. Orand A, Naliboff B, Gadd M, Shih W, Ju T, Presson AP, Mayer EA, Chang L. PMID: 27497153; PMCID: PMC5048544.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. 2015 James W. Freston Single Topic Conference: A Renaissance in the Understanding and Management of Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. 2016 07; 14(7):e77-86. Chang L, Heitkemper MM, Wiley JW, Camilleri M. PMID: 27237431.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    51. 2015 James W. Freston Single Topic Conference: A Renaissance in the Understanding and Management of Irritable Bowel Syndrome. Gastroenterology. 2016 07; 151(1):e1-8. Chang L, Heitkemper MM, Wiley JW, Camilleri M. PMID: 27215658; PMCID: PMC5410382.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression. Psychoneuroendocrinology. 2016 07; 69:67-76. Videlock EJ, Shih W, Adeyemo M, Mahurkar-Joshi S, Presson AP, Polytarchou C, Alberto M, Iliopoulos D, Mayer EA, Chang L. PMID: 27038676; PMCID: PMC4977028.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    53. Review article: epidemiology and quality of life in functional gastrointestinal disorders. Aliment Pharmacol Ther. 2004 Nov; 20 Suppl 7:31-9. Chang L. PMID: 15521853.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
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