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Friedman Theodore

Title(s)Chairman, INTERNAL MEDICINE
SchoolCharles Drew University
Phone(310) 668-5197
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    Other Positions
    Title(s)Associate Professor, Medicine


    Collapse Research 
    Collapse Research Activities and Funding
    Novel pathways in the pathogenesis and pathophysiology of NAFLD in Hispanics
    NIH/NIMHD R01MD012579Mar 12, 2019 - Nov 30, 2023
    Role: Co-Principal Investigator
    The mechanisms of the nicotine-induction of insulin resistance
    NIH/NIDA R21DA022342Sep 30, 2007 - Aug 31, 2010
    Role: Principal Investigator
    CDU Diversity-promoting Institutions Drug Abuse Research Development Program
    NIH/NIDA R24DA017298Sep 1, 2003 - Mar 31, 2019
    Role: Principal Investigator
    THE BIOLOGIC EFFECTS OF ANDROGENS IN MEN AND WOMEN
    NIH/NICHD U54HD041748Aug 15, 2003 - Oct 31, 2010
    Role: Principal Investigator
    Support of Competitive Research (SCORE) Institutional Development Award at Drew
    NIH/NIGMS S06GM068510Aug 1, 2003 - Aug 31, 2012
    Role: Co-Principal Investigator
    Chronic Nicotine's Activation of the HPA Axis
    NIH/NIDA R21DA016867Jul 20, 2003 - May 31, 2007
    Role: Principal Investigator
    HPA Axis Activation and Nicotine Use
    NIH/NIDA R21DA015466Jun 5, 2003 - Feb 29, 2008
    Role: Principal Investigator
    Genes and Proteins Leading to Addiction
    NIH/NIDA R01DA014659Aug 1, 2002 - Jul 31, 2010
    Role: Principal Investigator
    STRUCTURAL DETERMINANTS IN REGULATION OF POMC PROCESSING
    NIH/NIDA K21DA000276Jul 1, 1995 - Apr 30, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shao XM, Friedman TC. Pod-Mod vs. Conventional E-cigarettes: Nicotine Chemistry, pH and Health Effects. J Appl Physiol (1985). 2019 Dec 19. PMID: 31854246.
      View in: PubMed
    2. Wang J, Wang Y, Liu L, Lutfy K, Friedman TC, Liu Y, Jiang M, Liu Y. Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice. Clin Sci (Lond). 2019 Nov 15; 133(21):2189-2202. PMID: 31696216.
      View in: PubMed
    3. Shao XM, Lopez B, Nathan D, Wilson J, Bankole E, Tumoyan H, Munoz A, Espinoza-Derout J, Hasan KM, Chang S, Du C, Sinha-Hikim AP, Lutfy K, Friedman TC. A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers. J Neurosci Methods. 2019 Oct 01; 326:108376. PMID: 31361999.
      View in: PubMed
    4. Espinoza-Derout J, Hasan KM, Shao XM, Jordan MC, Sims C, Lee DL, Sinha S, Simmons Z, Mtume N, Liu Y, Roos KP, Sinha-Hikim AP, Friedman TC. Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice. Am J Physiol Heart Circ Physiol. 2019 Aug 01; 317(2):H445-H459. PMID: 31172811.
      View in: PubMed
    5. Espinoza-Derout J, Shao XM, Bankole E, Hasan KM, Mtume N, Liu Y, Sinha-Hikim AP, Friedman TC. Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis. Front Endocrinol (Lausanne). 2019; 10:320. PMID: 31214115.
      View in: PubMed
    6. Hasan KM, Friedman TC, Shao X, Parveen M, Sims C, Lee DL, Espinoza-Derout J, Sinha-Hikim I, Sinha-Hikim AP. E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. Hepatology. 2019 Jun; 69(6):2442-2454. PMID: 30664268.
      View in: PubMed
    7. Mojtahedzadeh M, Shaesteh N, Haykani M, Tran JLA, Mangubat M, Shahinian HK, Nachnani R, Zopey M, Saidian J, Thomas A, Lee ML, McCutcheon IE, Friedman TC. Low-Dose and Standard Overnight and Low Dose-Two Day Dexamethasone Suppression Tests in Patients with Mild and/or Episodic Hypercortisolism. Horm Metab Res. 2018 Jun; 50(6):453-461. PMID: 29719879.
      View in: PubMed
    8. Liu L, Wang Y, Wang J, Dong Y, Chang S, Liu X, Lutfy K, Chen H, Friedman TC, Jiang M, Liu Y. Enhanced hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to diet-induced visceral adiposity. Int J Obes (Lond). 2018 12; 42(12):1999-2011. PMID: 29568102.
      View in: PubMed
    9. Hasan MK, Friedman TC, Sims C, Lee DL, Espinoza-Derout J, Ume A, Chalfant V, Lee ML, Sinha-Hikim I, Lutfy K, Liu Y, Mahata SK, Sinha-Hikim AP. a7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling. Endocrinology. 2018 02 01; 159(2):931-944. PMID: 29272360.
      View in: PubMed
    10. Kermah D, Shaheen M, Pan D, Friedman TC. Association between secondhand smoke and obesity and glucose abnormalities: data from the National Health and Nutrition Examination Survey (NHANES 1999-2010). BMJ Open Diabetes Res Care. 2017; 5(1):e000324. PMID: 28405342.
      View in: PubMed
    11. Sinha-Hikim AP, Sinha-Hikim I, Friedman TC. Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. Front Endocrinol (Lausanne). 2017; 8:23. PMID: 28239368.
      View in: PubMed
    12. Sinha-Hikim I, Friedman TC, Falz M, Chalfant V, Hasan MK, Espinoza-Derout J, Lee DL, Sims C, Tran P, Mahata SK, Sinha-Hikim AP. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis. Cell Tissue Res. 2017 04; 368(1):159-170. PMID: 27917437.
      View in: PubMed
    13. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016 11; 12(11):684. PMID: 27688045.
      View in: PubMed
    14. Harris KK, Zopey M, Friedman TC. Metabolic effects of smoking cessation. Nat Rev Endocrinol. 2016 May; 12(5):299-308. PMID: 26939981.
      View in: PubMed
    15. Mojtahedzadeh M, Lee ML, Friedman TC. Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population. J Diabetes Complications. 2015 Nov-Dec; 29(8):1248-52. PMID: 26215435.
      View in: PubMed
    16. Wang Y, Yan C, Liu L, Wang W, Du H, Fan W, Lutfy K, Jiang M, Friedman TC, Liu Y. 11ß-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab. 2015 Jan 01; 308(1):E84-95. PMID: 25389364.
      View in: PubMed
    17. Huang G, Basaria S, Travison TG, Ho MH, Davda M, Mazer NA, Miciek R, Knapp PE, Zhang A, Collins L, Ursino M, Appleman E, Dzekov C, Stroh H, Ouellette M, Rundell T, Baby M, Bhatia NN, Khorram O, Friedman T, Storer TW, Bhasin S. Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial. Menopause. 2014 Jun; 21(6):612-23. PMID: 24281237.
      View in: PubMed
    18. Sinha-Hikim I, Friedman TC, Shin CS, Lee D, Ivey R, Sinha-Hikim AP. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology. 2014 Mar; 155(3):865-72. PMID: 24424058.
      View in: PubMed
    19. Wang Y, Liu L, Du H, Nagaoka Y, Fan W, Lutfy K, Friedman TC, Jiang M, Liu Y. Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab. 2014 Mar 01; 306(5):E543-51. PMID: 24381005.
      View in: PubMed
    20. Natividad LA, Torres OV, Friedman TC, O'Dell LE. Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behav Brain Res. 2013 Nov 15; 257:275-85. PMID: 24120402.
      View in: PubMed
    21. Liu L, Nagashima K, Yasuda T, Liu Y, Hu HR, He G, Feng B, Zhao M, Zhuang L, Zheng T, Friedman TC, Xiang K. Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. Diabetologia. 2013 Dec; 56(12):2609-18. PMID: 24018988.
      View in: PubMed
    22. Ren X, Lutfy K, Mangubat M, Ferrini MG, Lee ML, Liu Y, Friedman TC. Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes. 2013; 2013:764742. PMID: 24073333.
      View in: PubMed
    23. Nie Y, Ferrini MG, Liu Y, Anghel A, Paez Espinosa EV, Stuart RC, Lutfy K, Nillni EA, Friedman TC. Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides. 2013 Sep; 47:99-109. PMID: 23891651.
      View in: PubMed
    24. O'Dell LE, Natividad LA, Pipkin JA, Roman F, Torres I, Jurado J, Torres OV, Friedman TC, Tenayuca JM, Nazarian A. Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes. Addict Biol. 2014 Nov; 19(6):1006-19. PMID: 23834715.
      View in: PubMed
    25. Du H, Liu L, Wang Y, Nakagawa Y, Lyzlov A, Lutfy K, Friedman TC, Peng X, Liu Y. Specific reduction of G6PT may contribute to downregulation of hepatic 11ß-HSD1 in diabetic mice. J Mol Endocrinol. 2013 Apr; 50(2):167-78. PMID: 23267038.
      View in: PubMed
    26. Teruya SA, Bazargan-Hejazi S, Mojtahedzadeh M, Doshi M, Russell K, Parker-Kelly D, Friedman TC. A Review of Programs, Components and Outcomes in Biomedical Research Faculty Development. Int J Univ Teach Fac Dev. 2013; 4(4):223-236. PMID: 26120379.
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    27. Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 2012 Dec; 153(12):5809-20. PMID: 23093702.
      View in: PubMed
    28. Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. 2013 Feb; 36(2):260-6. PMID: 23033239.
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    29. Tweed JO, Hsia SH, Lutfy K, Friedman TC. The endocrine effects of nicotine and cigarette smoke. Trends Endocrinol Metab. 2012 Jul; 23(7):334-42. PMID: 22561025.
      View in: PubMed
    30. Nguyen AT, Marquez P, Hamid A, Kieffer B, Friedman TC, Lutfy K. The rewarding action of acute cocaine is reduced in ß-endorphin deficient but not in µ opioid receptor knockout mice. Eur J Pharmacol. 2012 Jul 05; 686(1-3):50-4. PMID: 22575525.
      View in: PubMed
    31. Rajavashisth TB, Shaheen M, Norris KC, Pan D, Sinha SK, Ortega J, Friedman TC. Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III. BMJ Open. 2012; 2:e000494. PMID: 22368296.
      View in: PubMed
    32. Lutfy K, Aimiuwu O, Mangubat M, Shin CS, Nerio N, Gomez R, Liu Y, Friedman TC. Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors. J Neurochem. 2012 Mar; 120(6):1108-16. PMID: 22191943.
      View in: PubMed
    33. Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Effect of nicotine on body composition in mice. J Endocrinol. 2012 Mar; 212(3):317-26. PMID: 22138237.
      View in: PubMed
    34. Friedman TC. Vitamin D supplementation to prevent the progression of prediabetes to diabetes: getting closer to a recommendation. Transl Res. 2011 Nov; 158(5):273-5. PMID: 22005266.
      View in: PubMed
    35. Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, Lutfy K. Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. Eur J Pharmacol. 2011 Jan 15; 650(2-3):563-7. PMID: 21044625.
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    36. Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M. Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic a-cells in mouse models of ß-cell regeneration. Islets. 2010 May-Jun; 2(3):149-55. PMID: 20657753.
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    37. Chen J, Patel R, Friedman TC, Jones KS. The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol. 2010; 23(1):82-90. PMID: 21278812.
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    38. Vuong C, Van Uum SH, O'Dell LE, Lutfy K, Friedman TC. The effects of opioids and opioid analogs on animal and human endocrine systems. Endocr Rev. 2010 Feb; 31(1):98-132. PMID: 19903933.
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    39. Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman TC. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol. 2008 Aug; 41(2):53-64. PMID: 18524870.
      View in: PubMed
    40. Yuen KC, Cook DM, Sahasranam P, Patel P, Ghods DE, Shahinian HK, Friedman TC. Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels. Clin Endocrinol (Oxf). 2008 Aug; 69(2):292-8. PMID: 18221393.
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    41. Sahasranam P, Tran MT, Mohamed H, Friedman TC. Multiglandular parathyroid carcinoma: a case report and brief review. South Med J. 2007 Aug; 100(8):841-4. PMID: 17713315.
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    42. Lutfy K, Brown MC, Nerio N, Aimiuwu O, Tran B, Anghel A, Friedman TC. Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis. J Neurochem. 2006 Dec; 99(5):1321-7. PMID: 17064351.
      View in: PubMed
    43. Espinosa VP, Ferrini M, Shen X, Lutfy K, Nillni EA, Friedman TC. Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E175-86. PMID: 16926379.
      View in: PubMed
    44. Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006 Nov; 147(11):5061-8. PMID: 16873540.
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    45. Perello M, Friedman T, Paez-Espinosa V, Shen X, Stuart RC, Nillni EA. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Endocrinology. 2006 Jun; 147(6):2705-16. PMID: 16497799.
      View in: PubMed
    46. Marquez P, Baliram R, Gajawada N, Friedman TC, Lutfy K. Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine. Behav Neurosci. 2006 Feb; 120(1):10-5. PMID: 16492112.
      View in: PubMed
    47. McGirr R, Ejbick CE, Carter DE, Andrews JD, Nie Y, Friedman TC, Dhanvantari S. Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells. Endocrinology. 2005 Oct; 146(10):4514-23. PMID: 15994347.
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    48. Hardiman A, Friedman TC, Grunwald WC, Furuta M, Zhu Z, Steiner DF, Cool DR. Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry. J Mol Endocrinol. 2005 Jun; 34(3):739-51. PMID: 15956344.
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    49. Shen X, Li QL, Brent GA, Friedman TC. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E236-45. PMID: 15585599.
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    50. Liu Y, Nakagawa Y, Wang Y, Sakurai R, Tripathi PV, Lutfy K, Friedman TC. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Diabetes. 2005 Jan; 54(1):32-40. PMID: 15616008.
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    51. Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest. 2004 Aug; 114(3):357-69. PMID: 15286802.
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    52. Wang C, Swerdloff R, Kipnes M, Matsumoto AM, Dobs AS, Cunningham G, Katznelson L, Weber TJ, Friedman TC, Snyder P, Levine HL. New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. J Clin Endocrinol Metab. 2004 Aug; 89(8):3821-9. PMID: 15292312.
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    53. Friedman TC. Prolactinomas. N Engl J Med. 2004 Mar 04; 350(10):1054-7; author reply 1054-7. PMID: 14999121.
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    54. Friedman TC, Shahinian H. Bilateral cerebral aneurysms impinging on the pituitary. Pituitary. 2004; 7(3):193-194. PMID: 16328569.
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    55. Choi HJ, Cornford M, Wang L, Sun J, Friedman TC. Acute chagas' disease presenting with a suprasellar mass and panhypopituitarism. Pituitary. 2004; 7(2):111-4. PMID: 15761661.
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    56. Liu Y, Nakagawa Y, Wang Y, Li R, Li X, Ohzeki T, Friedman TC. Leptin activation of corticosterone production in hepatocytes may contribute to the reversal of obesity and hyperglycemia in leptin-deficient ob/ob mice. Diabetes. 2003 Jun; 52(6):1409-16. PMID: 12765951.
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    57. Li QL, Naqvi S, Shen X, Liu YJ, Lindberg I, Friedman TC. Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues. Regul Pept. 2003 Feb 28; 110(3):197-205. PMID: 12573800.
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    58. Friedman TC, Norris KC. The role of vitamin D in mild to moderate chronic kidney disease. Trends Endocrinol Metab. 2002 Jul; 13(5):189-94. PMID: 12185664.
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    59. Padero MC, Bhasin S, Friedman TC. Androgen supplementation in older women: too much hype, not enough data. J Am Geriatr Soc. 2002 Jun; 50(6):1131-40. PMID: 12110078.
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